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Meta-analysis of clockwise reversals in WT males of Experiments 1 and 2. Legend: Forest plot of difference in clockwise reversals between male WT subjects gavaged with saline or LPS, measured from Experiment 1 (top green bar) and Experiment 2 (bottom green bar). The result of the meta-analysis is indicated by the red diamond. The width of the green bars and the red diamond indicate the range of the 95% confidence intervals for each, with the center representing the mean. WT males not treated with TLR4 antagonists were used for these analyses (total n = 15/group). See Additional file 18: Table S7 for statistics. (PPTX 45 kb)

Title: Independent ANOVAs from Experiment 1 suggest outcome variables that contribute to group differences highlighted by Pillai’s trace. Legend: Individual ANOVAs on outcome variables measured in Experiment 1. Significant results are boldfaced. F values are indicated in the “F” column, p values are indicated in the “Sig.” column and effect sizes (partial eta squared) are indicated in the “Partial η^2” column. For each ANOVA, hypothesis degrees of freedom is 1 and error degrees of freedom is 18. (DOCX 16 kb)

Meta-analysis of ambulatory distance in WT males of Experiments 1 and 2. Legend: Forest plot of difference in ambulatory distance between male WT subjects gavaged with saline or LPS, measured from Experiment 1 (top green bar) and Experiment 2 (bottom green bar). The result of the meta-analysis is indicated by the red diamond. The width of the green bars and the red diamond indicate the range of the 95% confidence intervals for each, with the center representing the mean. WT males not treated with TLR4 antagonists were used for these analyses (total n = 15/group). See Additional file 18: Table S7 for statistics. (PPTX 45 kb)

Title: Original classification and cross-validation of discriminant functions for Experiment 2 for cases grouped by gavage treatment and sex. Legend: Validation of discriminant functions for Experiment 2, for cases grouped by gavage treatment and sex, by original case classification and leave-one-out cross validation. 64.6% of the original grouped cases are correctly classified by the discriminant functions. In the leave-one-out cross-validation test, the discriminant functions are recalculated excluding one case, and all cases are recalculated. This algorithm is repeated for the exclusion of each case. In the leave-one-out test, 45.7% of cross-validated grouped cases were correctly classified. (DOCX 14 kb)

Title: Independent ANOVAs from Experiment 2 suggest outcome variables that contribute to group differences highlighted by Pillai’s trace. Legend: Individual ANOVAs on outcome variables measured in Experiment 2. Significant results are boldfaced. Trends are italicized. F values are indicated in the “F” column, p values are indicated in the “Sig.” column and effect sizes (partial eta squared) are indicated in the “Partial η^2” column. For each ANOVA, hypothesis degrees of freedom is 1 and error degrees of freedom is 111. (DOCX 39 kb)

Title: Meta-analysis of serum endotoxin levels in WT males of Experiments 1 and 2. Legend: Forest plot of difference in serum endotoxin levels between male WT subjects gavaged with saline or LPS, measured from Experiment 1 (top green bar) and Experiment 2 (bottom green bar). The result of the meta-analysis is indicated by the red diamond. The width of the green bars and the red diamond indicate the range of the 95% confidence intervals for each, with the center representing the mean. WT males not treated with TLR4 antagonists were used for these analyses (total n =â 15/group). (PPTX 45 kb)

Title: Meta-analysis of ambulatory episodes in WT males of Experiments 1 and 2. Legend: Forest plot of difference in ambulatory episodes between male WT subjects gavaged with saline or LPS, measured from Experiment 1 (top green bar) and Experiment 2 (bottom green bar). The result of the meta-analysis is indicated by the red diamond. The width of the green bars and the red diamond indicate the range of the 95% confidence intervals for each, with the center representing the mean. WT males not treated with TLR4 antagonists were used for these analyses (total n = 15/group). See Additional file 18: Table S7 for statistics. (PPTX 45 kb)

Title: Original classification and cross-validation of discriminant functions for Experiment 1. Legend: Validation of discriminant functions for Experiment 2, for cases grouped by (+)-naloxone treatment and sex, by original case classification and leave-one-out cross validation. 65.4% of the original grouped cases are correctly classified by the discriminant functions. In the leave-one-out cross-validation test, the discriminant functions are recalculated excluding one case, and all cases are recalculated. This algorithm is repeated for the exclusion of each case. In the leave-one-out test, 48.0% of cross-validated grouped cases were correctly classified. (DOCX 14 kb)

Title: Original classification and cross-validation of discriminant functions for Experiment 1. Legend: Validation of discriminant functions for Experiment 1 by original case classification and leave-one-out cross validation. 100% of the original grouped cases are correctly classified by the discriminant functions. In the leave-one-out cross-validation test, the discriminant functions are recalculated excluding one case, and all cases are recalculated. This algorithm is repeated for the exclusion of each case. In the leave-one-out test, 63.6% of cross-validated grouped cases were correctly classified. (DOCX 14 kb)

Title: Meta-analysis of ambulatory time in WT males of Experiments 1 and 2. Legend: Forest plot of difference in ambulatory time between male WT subjects gavaged with saline or LPS, measured from Experiment 1 (top green bar) and Experiment 2 (bottom green bar). The result of the meta-analysis is indicated by the red diamond. The width of the green bars and the red diamond indicate the range of the 95% confidence intervals for each, with the center representing the mean. WT males not treated with TLR4 antagonists were used for these analyses (total n = 15/group). See Additional file 18: Table S7 for statistics. (PPTX 45 kb)