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4. Induction of cellular immune response and anti-Salmonella enterica serovar typhi bactericidal antibodies in healthy volunteers by immunization with a vaccine candidate against typhoid fever.

Author

Salazar-González RM, Maldonado-Bernal C, Ramírez-Cruz NE, Rios-Sarabia N, Beltrán-Nava J, Castañón-González J, Castillo-Torres N, Palma-Aguirre JA, Carrera-Camargo M, López-Macías C, and Isibasi A

Subjects
Adolescent, Adult, Antibody Specificity immunology, Blood Bactericidal Activity immunology, Cell Proliferation drug effects, Chromatography, Gel, Double-Blind Method, Electrophoresis, Polyacrylamide Gel, Enzyme-Linked Immunosorbent Assay, Escherichia coli chemistry, Escherichia coli immunology, Humans, Immunoglobulin G blood, Immunoglobulin G immunology, Immunoglobulin M blood, Immunoglobulin M immunology, Interferon-gamma metabolism, Interleukin-4 metabolism, Leukocytes, Mononuclear drug effects, Leukocytes, Mononuclear immunology, Leukocytes, Mononuclear metabolism, Male, Porins immunology, Porins isolation & purification, Porins pharmacology, Salmonella typhi chemistry, Typhoid Fever immunology, Vaccination adverse effects, Antibody Formation immunology, Immunity, Cellular immunology, Salmonella typhi immunology, Typhoid Fever prevention & control, Vaccination methods
Abstract

Typhoid fever remains a serious public health problem. We have developed a vaccine from Salmonella enterica serovar typhi (S. typhi) outer-membrane proteins (OMPs) known as porins. A single subcutaneous dose of 10 microg of porins induced a five-fold (P = 0.05) seroconversion index consisting of IgM and IgG at 7 and 15 days after vaccination as well as the production of IgG1 and IgG2 isotypes. The porins-based vaccine induced a two-fold increase (P = 0.05) in bactericidal titres in volunteers, whom also developed a T-cell response characterized by the production of interferon-gamma (INF-gamma). Side effects after vaccination were mild and transient. The data showed that our S. typhi porins-based candidate vaccine is safe and immunogenic in healthy humans.

Published
2004
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