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12 results on '"Castillo, Izabella N."'

1. Adjuvant-dependent impact of inactivated SARS-CoV-2 vaccines during heterologous infection by a SARS-related coronavirus

Author

Dillard, Jacob A., Taft-Benz, Sharon A., Knight, Audrey C., Anderson, Elizabeth J., Pressey, Katia D., Parotti, Breantié, Martinez, Sabian A., Diaz, Jennifer L., Sarkar, Sanjay, Madden, Emily A., De la Cruz, Gabriela, Adams, Lily E., Dinnon, III, Kenneth H., Leist, Sarah R., Martinez, David R., Schäfer, Alexandra, Powers, John M., Yount, Jr., Boyd L., Castillo, Izabella N., Morales, Noah L., Burdick, Jane, Evangelista, Mia Katrina D., Ralph, Lauren M., Pankow, Nicholas C., Linnertz, Colton L., Lakshmanane, Premkumar, Montgomery, Stephanie A., Ferris, Martin T., Baric, Ralph S., Baxter, Victoria K., and Heise, Mark T.

Published
2024
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2. Hybrid immunity to SARS-CoV-2 arises from serological recall of IgG antibodies distinctly imprinted by infection or vaccination

Author

Voss, William N., Mallory, Michael L., Byrne, Patrick O., Marchioni, Jeffrey M., Knudson, Sean A., Powers, John M., Leist, Sarah R., Dadonaite, Bernadeta, Townsend, Douglas R., Kain, Jessica, Huang, Yimin, Satterwhite, Ed, Castillo, Izabella N., Mattocks, Melissa, Paresi, Chelsea, Munt, Jennifer E., Scobey, Trevor, Seeger, Allison, Premkumar, Lakshmanane, Bloom, Jesse D., Georgiou, George, McLellan, Jason S., Baric, Ralph S., Lavinder, Jason J., and Ippolito, Gregory C.

Published
2024
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3. Fc-mediated pan-sarbecovirus protection after alphavirus vector vaccination

Author

Adams, Lily E., Leist, Sarah R., Dinnon, Kenneth H., III, West, Ande, Gully, Kendra L., Anderson, Elizabeth J., Loome, Jennifer F., Madden, Emily A., Powers, John M., Schäfer, Alexandra, Sarkar, Sanjay, Castillo, Izabella N., Maron, Jenny S., McNamara, Ryan P., Bertera, Harry L., Zweigart, Mark R., Higgins, Jaclyn S., Hampton, Brea K., Premkumar, Lakshmanane, Alter, Galit, Montgomery, Stephanie A., Baxter, Victoria K., Heise, Mark T., and Baric, Ralph S.

Published
2023
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4. Hybrid immunity to SARS-CoV-2 arises from serological recall of IgG antibodies distinctly imprinted by infection or vaccination

Author

Voss, William N, primary, Mallory, Michael A., additional, Byrne, Patrick O., additional, Marchioni, Jeffrey M., additional, Knudson, Sean A., additional, Powers, John M., additional, Leist, Sarah R., additional, Dadonaite, Bernadeta, additional, Townsend, Douglas R., additional, Kain, Jessica, additional, Huang, Yimin, additional, Satterwhite, Ed, additional, Castillo, Izabella N., additional, Mattocks, Melissa, additional, Paresi, Chelsea, additional, Munt, Jennifer E., additional, Scobey, Trevor, additional, Seeger, Allison, additional, Premkumar, Lakshmanane, additional, Bloom, Jesse D., additional, Georgiou, George, additional, McLellan, Jason S., additional, Baric, Ralph S., additional, Lavinder, Jason J., additional, and Ippolito, Gregory C., additional

Published
2024
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5. The Antiviral Mechanism of Action of Molnupiravir in Humans with COVID-19

Author

Sheahan, Timothy P, primary, Stevens, Laura J, additional, Narowski, Tara M, additional, Krajewski, Taylor J, additional, Lee, Chanhwa, additional, Mollan, Katie R, additional, Gribble, Jennifer, additional, Moreria, Fernando R, additional, Castillo, Izabella N, additional, Cuadra, Edwing, additional, Alabanza, Paul, additional, James Loftis, Amy, additional, Coombs, Robert W, additional, Goecker, Erin A, additional, Greninger, Alexander L, additional, Chappell, James D, additional, Brown, Ariane J, additional, Won, John, additional, Lipansky, Felicia, additional, Holman, Wayne, additional, Szewczyk, Laura J, additional, Baric, Ralph S, additional, Painter, Wendy P, additional, Eron, Joseph J, additional, Premkumar, Lakshmanane, additional, Denison, Mark R, additional, and Fischer, William A, additional

Published
2023
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6. Investigation of the Host Kinome Response to Coronavirus Infection Reveals PI3K/mTOR Inhibitors as Betacoronavirus Antivirals.

Author

Fritch, Ethan J., Mordant, Angie L., Gilbert, Thomas S.K., Wells, Carrow I., Yang, Xuan, Barker, Natalie K., Madden, Emily A., Dinnon III, Kenneth H., Hou, Yixuan J., Tse, Longping V., Castillo, Izabella N., Sims, Amy C., Moorman, Nathaniel J., Lakshmanane, Premkumar, Willson, Timothy M., Herring, Laura E., Graves, Lee M., and Baric, Ralph S.

Published
2023
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7. Structure and neutralization mechanism of a human antibody targeting a complex Epitope on Zika virus

Author

Adams, Cameron, primary, Carbaugh, Derek L., additional, Shu, Bo, additional, Ng, Thiam-Seng, additional, Castillo, Izabella N., additional, Bhowmik, Ryan, additional, Segovia-Chumbez, Bruno, additional, Puhl, Ana C., additional, Graham, Stephen, additional, Diehl, Sean A., additional, Lazear, Helen M., additional, Lok, Shee-mei, additional, de Silva, Aravinda M., additional, and Premkumar, Lakshmanane, additional

Published
2023
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9. Fc mediated pan-sarbecovirus protection after alphavirus vector vaccination

Author

Adams, Lily E., primary, Leist, Sarah R., additional, Dinnon, Kenneth H., additional, West, Ande, additional, Gully, Kendra L., additional, Anderson, Elizabeth J., additional, Loome, Jennifer F., additional, Madden, Emily A., additional, Powers, John M., additional, Schäfer, Alexandra, additional, Sarkar, Sanjay, additional, Castillo, Izabella N., additional, Maron, Jenny S., additional, McNamara, Ryan P., additional, Bertera, Harry L., additional, Zweigert, Mark R., additional, Higgins, Jaclyn S., additional, Hampton, Brea K., additional, Premkumar, Lakshmanane, additional, Alter, Galit, additional, Montgomery, Stephanie A., additional, Baxter, Victoria K., additional, Heise, Mark T., additional, and Baric, Ralph S., additional

Published
2022
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10. Structure and Neutralization Mechanism of a Human Antibody Targeting a Complex Epitope on Zika Virus

Author

Adams, Cameron, primary, Carbaugh, Derek L., additional, Shu, Bo, additional, Ng, Thiam-Seng, additional, Castillo, Izabella N., additional, Bowmik, Ryan, additional, Segovia-Chumbez, Bruno, additional, Puhl, Ana C., additional, Graham, Stephen, additional, Diehl, Sean A., additional, Lazear, Helen M., additional, Lok, Shee-mei, additional, de Silva, Aravinda M., additional, and Premkumar, Lakshmanane, additional

Published
2022
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11. Hybrid immunity to SARS-CoV-2 arises from serological recall of IgG antibodies distinctly imprinted by infection or vaccination.

Author

Voss WN, Mallory MA, Byrne PO, Marchioni JM, Knudson SA, Powers JM, Leist SR, Dadonaite B, Townsend DR, Kain J, Huang Y, Satterwhite E, Castillo IN, Mattocks M, Paresi C, Munt JE, Scobey T, Seeger A, Premkumar L, Bloom JD, Georgiou G, McLellan JS, Baric RS, Lavinder JJ, and Ippolito GC

Abstract

We used plasma IgG proteomics to study the molecular composition and temporal durability of polyclonal IgG antibodies triggered by ancestral SARS-CoV-2 infection, vaccination, or their combination ("hybrid immunity"). Infection, whether primary or post-vaccination, mainly triggered an anti-spike antibody response to the S2 domain, while vaccination predominantly induced anti-RBD antibodies. Immunological imprinting persisted after a secondary (hybrid) exposure, with >60% of the ensuing serological response originating from the initial antibodies generated during the first exposure. We highlight one instance where hybrid immunity arising from breakthrough infection resulted in a marked increase in the breadth and affinity of a highly abundant vaccination-elicited plasma IgG antibody, SC27. With an intrinsic binding affinity surpassing a theoretical maximum (K D < 5 pM), SC27 demonstrated potent neutralization of various SARS-CoV-2 variants and SARS-like zoonotic viruses (IC 50 ∼0.1-1.75 nM) and provided robust protection in vivo . Cryo-EM structural analysis unveiled that SC27 binds to the RBD class 1/4 epitope, with both VH and VL significantly contributing to the binding interface. These findings suggest that exceptionally broad and potent antibodies can be prevalent in plasma and can largely dictate the nature of serological neutralization., Highlights: ▪ Infection and vaccination elicit unique IgG antibody profiles at the molecular level▪ Immunological imprinting varies between infection (S2/NTD) and vaccination (RBD)▪ Hybrid immunity maintains the imprint of first infection or first vaccination▪ Hybrid immune IgG plasma mAbs have superior neutralization potency and breadth.

Published
2024
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12. Fc mediated pan-sarbecovirus protection after alphavirus vector vaccination.

Author

Adams LE, Leist SR, Dinnon KH, West A, Gully KL, Anderson EJ, Loome JF, Madden EA, Powers JM, Schäfer A, Sarkar S, Castillo IN, Maron JS, McNamara RP, Bertera HL, Zweigert MR, Higgins JS, Hampton BK, Premkumar L, Alter G, Montgomery SA, Baxter VK, Heise MT, and Baric RS

Abstract

Two group 2B β-coronaviruses (sarbecoviruses) have caused regional and global epidemics in modern history. The mechanisms of cross protection driven by the sarbecovirus spike, a dominant immunogen, are less clear yet critically important for pan-sarbecovirus vaccine development. We evaluated the mechanisms of cross-sarbecovirus protective immunity using a panel of alphavirus-vectored vaccines covering bat to human strains. While vaccination did not prevent virus replication, it protected against lethal heterologous disease outcomes in both SARS-CoV-2 and clade 2 bat sarbecovirus HKU3-SRBD challenge models. The spike vaccines tested primarily elicited a highly S1-specific homologous neutralizing antibody response with no detectable cross-virus neutralization. We found non-neutralizing antibody functions that mediated cross protection in wild-type mice were mechanistically linked to FcgR4 and spike S2-binding antibodies. Protection was lost in FcR knockout mice, further supporting a model for non-neutralizing, protective antibodies. These data highlight the importance of FcR-mediated cross-protective immune responses in universal pan-sarbecovirus vaccine designs.

Published
2022
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