167 results on '"Castilla, Lucio H."'
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2. Runx1-R188Q germ line mutation induces inflammation and predisposition to hematologic malignancies in mice
3. ZBP1 activation triggers hematopoietic stem and progenitor cell death resulting in bone marrow failure in mice
4. Molecular Basis and Targeted Inhibition of CBFβ-SMMHC Acute Myeloid Leukemia
5. Runx1-R188Q germline mutation induces inflammation and predisposition to hematologic malignancies in mice
6. RUNX1 is required in granulocyte–monocyte progenitors to attenuate inflammatory cytokine production by neutrophils
7. RUNX1 is required for oncogenic Myb and Myc enhancer activity in T-cell acute lymphoblastic leukemia
8. Impaired Granulopoiesis, Myelodysplasia, and Early Lethality in CCAAT/Enhancer Binding Protein ε -deficient Mice
9. RUNX1 is required in granulocyte-monocyte progenitors to attenuate inflammatory cytokine production by neutrophils
10. Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers
11. A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice
12. NrasG12D oncoprotein inhibits apoptosis of preleukemic cells expressing Cbfβ-SMMHC via activation of MEK/ERK axis
13. ATACseqQC: a Bioconductor package for post-alignment quality assessment of ATAC-seq data
14. Isolation of Gene Sequences from the BRCA1 Region of Chromosome 17q21 by Exon Amplification
15. The CBFβ-SMMHC/NRP1 Axis Regulates FLT3 and TGF-Beta Pathways in Inv(16) Acute Myeloid Leukemia
16. Germline Runx1 Mutations Induce Inflammation in Hematopoietic Stem and Progenitor Cells and Predispose to Hematologic Malignancies
17. CHEMICAL BIOLOGY: A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice
18. Runx2 induces acute myeloid leukemia in cooperation with Cbfβ-SMMHC in mice
19. Blood / Core binding factor leukemia hijacks T-cell prone PU.1 antisense promoter
20. Interplay between Inflammatory Microenvironment and RUNX1-Mediated Transcriptomic Changes Drives Defective Hematopoiesis in Familial Platelet Disorder
21. C/EBPα in Leukemogenesis: A Matter of Being in the Right Place with the Right Signals
22. Cbfβ-SMMHC impairs differentiation of common lymphoid progenitors and reveals an essential role for RUNX in early B-cell development
23. CBFB-MYH11 hinders early T-cell development and induces massive cell death in the thymus
24. Cbfβ-SMMHC induces distinct abnormal myeloid progenitors able to develop acute myeloid leukemia
25. Core Binding Factor Leukemias Utilize a Physiologic Sense/Antisense Promoter Switch Employed By T-Cells
26. Abstract 5041: Inhibition of RUNX-CBFβ binding reduces RSPO3 expression and EMT features in breast cancer cells
27. NRAS palmitoylation and oncogenic fitness
28. Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11
29. Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein xi-deficient mice
30. Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11
31. Genetic changes accompanying increased fitness in evolving populations of Escherichia coli
32. Role of Cbfbin hematopoiesis and perturbations resulting from expression of the leukemogenic fusion gene Cbfb-MYH11
33. CBFβ-SMMHC Inhibition Disrupts Enhancer Chromatin Dynamics and Represses MYC Transcriptional Program in Inv(16) Leukemia
34. Corrigendum to: “Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers” [EBioMedicine 8 (2016) 117–131]
35. HIF-1α Promotes Cbfbeta-SMMHC-Induced Acute Myeloid Leukemia Development
36. The Leukemogenic Function of the inv(16) Fusion Gene CBFB-MYH11
37. Selective Inhibition of the Leukemia Fusion Protein CBFβ-SMMHC By Small Molecule AI-10-49 in the Treatment of Inv(16) AML
38. Deletion Of Core Binding Factors Runx1 and Runx2 Leads To Perturbed Hematopoiesis In Multiple Lineages
39. Transcript identification in the BRCA1 candidate region
40. A Small Molecule Inhibitor of the CBFβ-SMMHC/RUNX Interaction Attenuates Inv(16) Leukemia in Vivo
41. RUNX1 is required for oncogenic Myband Mycenhancer activity in T-cell acute lymphoblastic leukemia
42. CBFB-MYH11 hinders early T-cell development and induces massive cell death in the thymus
43. Cbfβ Reduces Cbfβ-SMMHC–Associated Acute Myeloid Leukemia in Mice
44. Selection of Early-Occurring Mutations Dictates Hormone-Independent Progressionin Mouse Mammary TumorLines
45. PLAGL2 Cooperates in Leukemia Development by Direcly Inducing c-Mpl Expression.
46. The Role of CBFβ in T Cell Development.
47. Cbfb-MYH11 Induces Expansion of a Lin-Kit+Sca1- Abnormal Progenitor Compartment that Predisposes Acute Myeloid Leukemia in Mice.
48. Progression of Pregnancy-Dependent Mouse Mammary Tumors after Long Dormancy Periods. Involvement of Wnt Pathway Activation
49. Role of Cbfb in hematopoiesis and perturbations resulting from expression of the leukemogenic fusion gene Cbfb-MYH11
50. The fusion gene Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia
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