Search

Your search keyword '"Castilla, Jesus"' showing total 154 results
Start Over Author "Castilla, Jesus"
154 results on '"Castilla, Jesus"'

2. Association between pre-diagnostic circulating lipid metabolites and colorectal cancer risk: a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author

Harewood, Rhea, Rothwell, Joseph A., Bešević, Jelena, Viallon, Vivian, Achaintre, David, Gicquiau, Audrey, Rinaldi, Sabina, Wedekind, Roland, Prehn, Cornelia, Adamski, Jerzy, Schmidt, Julie A., Jacobs, Inarie, Tjønneland, Anne, Olsen, Anja, Severi, Gianluca, Kaaks, Rudolf, Katzke, Verena, Schulze, Matthias B., Prada, Marcela, Masala, Giovanna, Agnoli, Claudia, Panico, Salvatore, Sacerdote, Carlotta, Jakszyn, Paula Gabriela, Sánchez, Maria-Jose, Castilla, Jesús, Chirlaque, María-Dolores, Atxega, Amaia Aizpurua, van Guelpen, Bethany, Heath, Alicia K., Papier, Keren, Tong, Tammy Y.N., Summers, Scott A., Playdon, Mary, Cross, Amanda J., Keski-Rahkonen, Pekka, Chajès, Véronique, Murphy, Neil, and Gunter, Marc J.

Published
2024
Full Text
View/download PDF

7. Serotype Replacement after Introduction of 10-Valent and 13-Valent Pneumococcal Conjugate Vaccines in 10 Countries, Europe

Author

Hanquet, Germaine, Krizova, Pavla, Dalby, Tina, Ladhani, Shamez N., Nuorti, J. Pekka, Danis, Kostas, Mereckiene, Jolita, Knol, Mirjam J., Winje, Brita A., Ciruela, Pilar, de Miguel, Sara, Portillo, Maria Eugenia, MacDonald, Laura, Morfeldt, Eva, Kozakova, Jana, Valentiner-Branth, Palle, Fry, Norman K., Rinta-Kokko, Hanna, Varon, Emmanuelle, Corcoran, Mary, van der Ende, Arie, Vestrheim, Didrik F., Munoz-Almagro, Carmen, Sanz, Juan-Carlos, Castilla, Jesus, Smith, Andrew, Henriques-Normark, Birgitta, Colzani, Edoardo, Pastore-Celentano, Lucia, and Savulescu, Camelia

Subjects
Conjugate vaccines -- Patient outcomes, Pneumococcal infections -- Statistics -- Causes of -- Prevention, Communicable diseases in children -- Statistics -- Causes of -- Prevention, Pneumococcal vaccine -- Patient outcomes, Health
Abstract

Starting in 2010-2011, most countries in Europe progressively replaced the 7-valent pneumococcal conjugate vaccines (PCV7) in the infant immunization schedule with the 10-valent (PCV10) vaccine, 13-valent (PCV13) vaccine, or both [...]

Published
2022
Full Text
View/download PDF

9. Impact of pre‐existing cardiometabolic diseases on metastatic cancer stage at diagnosis: a prospective multinational cohort study

Author

Jansana, Anna, primary, Auguste, Aviane, additional, Kvaskoff, Marina, additional, Fournier, Agnès, additional, Fontvieille, Emma, additional, Peruchet‐Noray, Laia, additional, Biessy, Carine, additional, Cordova, Reynalda, additional, Nielsen Petersen, Kristina Elin, additional, Tjønneland, Anne, additional, Katzke, Verena, additional, Kaaks, Rudolf, additional, Ricceri, Fulvio, additional, Panico, Salvatore, additional, Contiero, Paolo, additional, Sánchez, Maria‐Jose, additional, Castilla, Jesus, additional, Crous‐Bou, Marta, additional, Heath, Alicia, additional, Aglago, Elom Kouassivi, additional, Weiderpass, Elisabete, additional, Gunter, Marc James, additional, Ferrari, Pietro, additional, Riboli, Elio, additional, Viallon, Vivian, additional, and Freisling, Heinz, additional

Published
2024
Full Text
View/download PDF

10. Impact of pre-existing cardiometabolic diseases on metastatic cancer stage at diagnosis:a prospective multinational cohort study

Author

Jansana, Anna, Auguste, Aviane, Kvaskoff, Marina, Fournier, Agnès, Fontvieille, Emma, Peruchet-Noray, Laia, Biessy, Carine, Cordova, Reynalda, Nielsen Petersen, Kristina Elin, Tjønneland, Anne, Katzke, Verena, Kaaks, Rudolf, Ricceri, Fulvio, Panico, Salvatore, Contiero, Paolo, Sánchez, Maria-Jose, Castilla, Jesus, Crous-Bou, Marta, Heath, Alicia, Aglago, Elom Kouassivi, Weiderpass, Elisabete, Gunter, Marc James, Ferrari, Pietro, Riboli, Elio, Viallon, Vivian, Freisling, Heinz, Jansana, Anna, Auguste, Aviane, Kvaskoff, Marina, Fournier, Agnès, Fontvieille, Emma, Peruchet-Noray, Laia, Biessy, Carine, Cordova, Reynalda, Nielsen Petersen, Kristina Elin, Tjønneland, Anne, Katzke, Verena, Kaaks, Rudolf, Ricceri, Fulvio, Panico, Salvatore, Contiero, Paolo, Sánchez, Maria-Jose, Castilla, Jesus, Crous-Bou, Marta, Heath, Alicia, Aglago, Elom Kouassivi, Weiderpass, Elisabete, Gunter, Marc James, Ferrari, Pietro, Riboli, Elio, Viallon, Vivian, and Freisling, Heinz

Abstract

Owing to shared risk factors between cardiometabolic diseases (CMDs) and cancer, coupled with population aging, the lifetime risk of an individual developing cancer after a CMD is increasing. Furthermore, biological mechanisms such as insulin resistance or inflammation may not only predispose individuals with CMD to an elevated risk of certain types of cancer but also to a diagnosis of cancer at an advanced stage, Owing to shared risk factors between cardiometabolic diseases (CMDs) and cancer, coupled with population aging, the lifetime risk of an individual developing cancer after a CMD is increasing. Furthermore, biological mechanisms such as insulin resistance or inflammation may not only predispose individuals with CMD to an elevated risk of certain types of cancer but also to a diagnosis of cancer at an advanced stage

Published
2024

14. Effect of influenza vaccination in patients with asthma

Author

Martinez-Baz, Ivan, Navascues, Ana, Casado, Itziar, Portillo, Maria Eugenia, Guevara, Marcela, Gomez-Ibanez, Carlos, Burgui, Cristina, Ezpeleta, Carmen, and Castilla, Jesus

Subjects
Asthmatics -- Testing, Influenza vaccines -- Testing, Influenza -- Prevention -- Demographic aspects -- Risk factors, Health
Abstract

BACKGROUND: Although annual influenza vaccination is recommended for persons with asthma, its effectiveness in this patient population is not well described. We evaluated the effect of influenza vaccination in the current and previous seasons in preventing influenza among people with asthma. METHODS: Using population health data from the Navarre region of Spain for the 2015/16 to 2019/20 influenza seasons, we conducted a test-negative case-control study to assess the effect of influenza vaccination in the current and 5 previous seasons. From patients presenting to hospitals and primary health care centres with influenza-like illness who underwent testing for influenza, we estimated the effects of influenza vaccination among patients with asthma overall and between those presenting as inpatients or outpatients, as well as between patients with and without asthma. RESULTS: Of 1032 patients who had asthma and were tested, we confirmed that 421 had influenza and the remaining 611 were test-negative controls. We found that the average effect of influenza vaccination was 43% (adjusted odds ratio [OR] 0.57, 95% confidence interval [CI] 0.40 to 0.80) for current-season vaccination regardless of previous doses, and 38% (adjusted OR 0.62, 95% CI 0.39 to 0.96) for vaccination in previous seasons only. Effects were similar for outpatients and inpatients. Among patients with asthma and confirmed influenza, current-season vaccination did not reduce the odds of hospital admission (adjusted OR 1.05, 95% CI 0.51 to 2.18). Influenza vaccination effects were similar for patients with and without asthma. INTERPRETATION: We estimated that, on average, current or previous influenza vaccination of people with asthma prevented almost half of influenza cases. These results support recommendations that people with asthma receive influenza vaccination., Influenza can lead to serious complications in people with risk factors, and the main preventive measure is vaccination. (1) Influenza infection can exacerbate symptoms of asthma. Because people with asthma [...]

Published
2021
Full Text
View/download PDF

17. Epstein Barr virus antibody reactivity and gastric cancer: A population-based case-control study

Author

Aragonés, Nuria, Fernández de Larrea, Nerea, Pastor-Barriuso, Roberto, Michel, Angelika, Romero, Beatriz, Pawlita, Michael, Mayorgas-Torralba, Sara, Martín, Vicente, Moreno, Victor, Casabonne, Delphine, Castilla, Jesús, Fernandez-Tardón, Guillermo, Dierssen-Sotos, Trinidad, Capelo, Rocío, Salas, Dolores, Salcedo-Bellido, Inmaculada, Chirlaque, María Dolores, Brenner, Nicole, Pedraza, Manuela, Bessa, Xavier, Pérez-Gómez, Beatriz, Butt, Julia, Kogevinas, Manolis, del Campo, Rosa, de Sanjosé, Silvia, Waterboer, Tim, and Pollán, Marina

Published
2019
Full Text
View/download PDF

18. Influenza vaccine effectiveness in Europe: Results from the 2022–23 VEBIS (Vaccine Effectiveness, Burden and Impact Studies) primary care multicentre study

Author

Maurel, Marine, primary, Pozo, Francisco, additional, Pérez-Gimeno, Gloria, additional, Buda, Silke, additional, Sève, Noémie, additional, Oroszi, Beatrix, additional, Hooiveld, Mariette, additional, Gómez, Verónica, additional, Domegan, Lisa, additional, Martínez-Baz, Iván, additional, Ilić, Maja, additional, Carnahan, AnnaSara, additional, Mihai, Maria Elena, additional, Martinez, Ana, additional, Goerlitz, Luise, additional, ENOUF, Vincent, additional, Horvath, Judit Krisztina, additional, Dijkstra, Frederika, additional, Rodrigues, Ana Paula, additional, Bennett, Charlene, additional, Trobajo-Sanmartín, Camino, additional, Mlinarić, Ivan, additional, Latorre-Margalef, Neus, additional, Ivanciuc, Alina, additional, Lopez, Aurora, additional, Dürrwald, Ralf, additional, Falchi, Alessandra, additional, Túri, Gergő, additional, Meijer, Adam, additional, Melo, Aryse, additional, O'Donnell, Joan, additional, Castilla, Jesus, additional, Vučina, Vesna Višekruna, additional, Hagey, Tove Samuelsson, additional, Lazar, Mihaela, additional, Kaczmarek, Marlena, additional, Bacci, Sabrina, additional, Kissling, Esther, additional, and team, VEBIS study, additional

Published
2023
Full Text
View/download PDF

19. Vaccine effectiveness against influenza hospitalisation in adults during the 2022/23 mixed season of influenza A(H1N1)pdm09, A(H3N2) and B circulation, Europe: VEBIS SARI VE hospital network

Author

Rose, Angela, primary, Pozo, Francisco, additional, Martínez-Baz, Iván, additional, Mazagatos, Clara, additional, Bossuyt, Nathalie, additional, Cauchi, John Paul, additional, Petrovic, Goranka, additional, Loghin, Isabela, additional, Vaikutyte, Roberta, additional, Buda, Silke, additional, Machado, Ausenda, additional, Duffy, Roisin, additional, Oroszi, Beatrix, additional, Howard, Jennifer, additional, Echeverria, Aitziber, additional, Salete, Cristina, additional, Barbezange, Cyril, additional, Dziugyte, Ausra, additional, Nonkovic, Diana, additional, Popescu, Corneliu, additional, Majauskaite, Fausta, additional, Tolksdorf, Kristin, additional, Gómez, Verónica, additional, Domegan, Lisa, additional, Horvath, Judit, additional, Castilla, Jesus, additional, García-Vázquez, Miriam, additional, Demuyser, Thomas, additional, Borg, Maria-Louise, additional, Tabain, Irena, additional, Lazar, Mihaela, additional, Kubiliute, Ieva, additional, Dürrwald, Ralf, additional, Guiomar, Raquel, additional, Donnell, Joan O, additional, Krisztalovics, Katalin, additional, Nicolay, Nathalie, additional, Bacci, Sabrina, additional, and Kissling, Esther, additional

Published
2023
Full Text
View/download PDF

20. Effectiveness of COVID-19 vaccines administered in the 2023 autumnal campaigns in Europe: Results from the VEBIS primary care test-negative design study, September 2023–January 2024

Author

Laniece Delaunay, Charlotte, Melo, Aryse, Maurel, Marine, Mazagatos, Clara, Goerlitz, Luise, O’Donnell, Joan, Oroszi, Beatrix, Sève, Noémie, Rodrigues, Ana Paula, Martínez-Baz, Iván, Meijer, Adam, Mlinarić, Ivan, Latorre-Margalef, Neus, Lazăr, Mihaela, Pérez-Gimeno, Gloria, Dürrwald, Ralf, Bennett, Charlene, Túri, Gergő, Rameix-Welti, Marie-Anne, Guiomar, Raquel, Castilla, Jesús, Hooiveld, Mariëtte, Kurečić Filipović, Sanja, Samuelsson Hagey, Tove, Dijkstra, Frederika, Borges, Vitor, Ramos Marín, Violeta, Bacci, Sabrina, Kaczmarek, Marlena, and Kissling, Esther

Published
2024
Full Text
View/download PDF

25. Reduction in the risk of mpox infection after MVA-BN vaccination in individuals on HIV pre-exposure prophylaxis: a Spanish cohort study

Author

Fontan-Vela, Mario, primary, Hernando, Victoria, additional, Olmedo, Carmen, additional, Coma, Ermengol, additional, Martinez, Montse, additional, Moreno, David, additional, Lorusso, Nicola, additional, Vazquez Torres, Maria, additional, Barbas del Buey, Jose Francisco, additional, Roig, Javier, additional, Pastor, Eliseo, additional, Galmes Truyols, Antonia, additional, Artigues Serra, Francisca, additional, Sancho Martinez, Rosa Maria, additional, Latasa Zamalloa, Pello, additional, Perez Martinez, Olaia, additional, Vazquez Estepa, Ana, additional, Garcia Rojas, Amos, additional, Barreno Estevez, Ana Isabel, additional, Sanchez-Migallon Naranjo, Alonso, additional, Perez Martin, Jaime Jesus, additional, Peces Jimenez, Pilar, additional, Morales Romero, Raquel, additional, Castilla, Jesus, additional, Garcia Cenoz, Manuel, additional, Huerta, Marta, additional, Boone, An Lieve Dirk, additional, Macias Ortiz, Maria Jose, additional, Alvarez Rio, Virginia, additional, Rodriguez Recio, Maria Jesus, additional, Merino Diaz, Maria, additional, Berradre Saenz, Belen, additional, Teresa-Villegas, Maria, additional, Limia, Aurora, additional, Diaz, Asuncion, additional, and Monge, Susana, additional

Published
2023
Full Text
View/download PDF

26. Helicobacter pylori serological biomarkers of gastric cancer risk in the MCC-Spain case-control Study

Author

Fernández de Larrea-Baz, Nerea, Pérez-Gómez, Beatriz, Michel, Angelika, Romero, Beatriz, Lope, Virginia, Pawlita, Michael, Fernández-Villa, Tania, Moreno, Victor, Martín, Vicente, Willhauck-Fleckenstein, Martina, López-Abente, Gonzalo, Castilla, Jesús, Fernández-Tardón, Guillermo, Dierssen-Sotos, Trinidad, Santibáñez, Miguel, Peiró, Rosana, Jiménez-Moleón, José Juan, Navarro, Carmen, Castaño-Vinyals, Gemma, Kogevinas, Manolis, Pollán, Marina, de Sanjosé, Silvia, del Campo, Rosa, Waterboer, Tim, and Aragonés, Nuria

Published
2017
Full Text
View/download PDF

28. Effect of high-valency pneumococcal conjugate vaccines on invasive pneumococcal disease in children in SpIDnet countries: an observational multicentre study

Author

Savulescu, Camelia, Krizova, Pavla, Lepoutre, Agnes, Mereckiene, Jolita, Vestrheim, Didrik F, Ciruela, Pilar, Ordobas, Maria, Guevara, Marcela, McDonald, Eisin, Morfeldt, Eva, Kozakova, Jana, Varon, Emmanuelle, Cotter, Suzanne, Winje, Brita A, Munoz-Almagro, Carmen, Garcia, Luis, Castilla, Jesus, Smith, Andrew, Henriques-Normark, Birgitta, Celentano, Lucia Pastore, and Hanquet, Germaine

Published
2017
Full Text
View/download PDF

31. Effectiveness of seasonal influenza vaccination in community-dwelling elderly people: an individual participant data meta-analysis of test-negative design case-control studies

Author

Darvishian, Maryam, van den Heuvel, Edwin R, Bissielo, Ange, Castilla, Jesus, Cohen, Cheryl, Englund, Helene, Gefenaite, Giedre, Huang, Wan-Ting, la Bastide-van Gemert, Sacha, Martinez-Baz, Iván, McAnerney, Johanna M, Ntshoe, Genevie M, Suzuki, Motoi, Turner, Nikki, and Hak, Eelko

Published
2017
Full Text
View/download PDF

34. Monitoring COVID-19 vaccine effectiveness against COVID-19 hospitalisation and death using electronic health registries in ≥65-years-old population in six European countries, October 2021 to November 2022

Author

Kislaya, Irina, primary, Sentís, Alexis, additional, Starrfelt, Jostein, additional, Nunes, Baltasar, additional, Martínez-Baz, Iván, additional, Nielsen, Katrine Finderup, additional, AlKerwi, Ala'a, additional, Braeye, Toon, additional, Fontán-Vela, Mario, additional, Bacci, Sabrina, additional, Meijerink, Hinta, additional, Castilla, Jesus, additional, Emborg, Hanne-Dorthe, additional, Hansen, Christian Holm, additional, Schmitz, Susanne, additional, Valenciano, Marta, additional, Evercooren, Izaak Van, additional, Nardone, Anthony, additional, Nicolay, Nathalie, additional, and Monge, Susana, additional

Published
2023
Full Text
View/download PDF

38. Visualizing knowledge and attitude factors related to influenza vaccination of physicians

Author

Alonso, Jordi, Baricot, Maretva, Caleró, Sebastian, Caylà, Joan, Lafuente, Sara, Rius, Cristina, Torner, Nuria, Diaz, José, Cenoz, Manuel García, Baz, Iván Martínez, Quintana, José María, González, Amaia Bilbao, Antón-Ladislao, Ane, García-Gutiérrez, Susana, Soldevila, Núria, González-Candelas, Fernando, Godoy, Pere, Castilla, Jesús, Mayoral, José María, Astray, Jenaro, Martín, Vicente, Tamames, Sonia, Toledo, Diana, Aguirre, Urko, and Domínguez, Angela

Published
2015
Full Text
View/download PDF

39. Repeated influenza vaccination for preventing severe and fatal influenza infection in older adults: a multicentre case-control study

Author

Casado, Itziar, Dominguez, Angela, Toledo, Diana, Chamorro, Judith, Astray, Jenaro, Egurrola, Mikel, Fernandez-Sierra, Maria Amelia, Martin, Vicente, Morales-Suarez-Varela, Maria, Godoy, Pere, and Castilla, Jesus

Subjects
Influenza vaccines -- Dosage and administration, Elderly -- Health aspects, Influenza -- Risk factors -- Drug therapy, Health
Abstract

BACKGROUND: The effectiveness of repeated vaccination for influenza to prevent severe cases remains unclear. We evaluated the effectiveness of influenza vaccination on preventing admissions to hospital for influenza and reducing disease severity. METHODS: We conducted a case-control study in 20 hospitals in Spain during the 2013/14 and 2014/15 influenza seasons. Community-dwelling adults aged 65 years or older who were admitted to hospital for laboratory-confirmed influenza were matched with inpatient controls by sex, age, hospital and admission date. The effectiveness of vaccination in the current and 3 previous seasons in preventing influenza was estimated for inpatients with nonsevere influenza and for those with severe influenza who were admitted to intensive care units (ICUs) or who died. RESULTS: We enrolled 130 inpatients with severe and 598 with nonsevere influenza who were matched to 333 and 1493 controls, respectively. Compared with patients who were unvaccinated in the current and 3 previous seasons, adjusted effectiveness of influenza vaccination in the current and any previous season was 31% (95% confidence interval [CI] 13%-46%) in preventing admission to hospital for nonsevere influenza, 74% (95% CI 42%-88%) in preventing admissions to ICU and 70% (95% CI 34%-87%) in preventing death. Vaccination in the current season only had no significant effect on cases of severe influenza. Among inpatients with influenza, vaccination in the current and any previous season reduced the risk of severe outcomes (adjusted odds ratio 0.45, 95% CI 0.26-0.76). INTERPRETATION: Among older adults, repeated vaccination for influenza was twice as effective in preventing severe influenza compared with nonsevere influenza in patients who were admitted to hospital, which is attributable to the combination of the number of admissions to hospital for influenza that were prevented and reduced disease severity. These results reinforce recommendations for annual vaccination for influenza in older adults., Seasonal influenza has a large effect on admissions to hospital and deaths among older adults. (1,2) Influenza vaccination is effective in preventing visits to primary health care and hospital admissions [...]

Published
2018
Full Text
View/download PDF

41. Influenza vaccine effectiveness against influenza A subtypes in Europe: results from the 2021–22 I-MOVE primary care multicentre study

Author

Kissling, Esther, primary, Pozo, Francisco, additional, Martínez-Baz, Iván, additional, Buda, Silke, additional, Vilcu, Ana-Maria, additional, Domegan, Lisa, additional, Ateca, Clara Mazagatos, additional, Dijkstra, Frederika, additional, Latorre-Margalef, Neus, additional, Filipovićović, Sanja Kurečić, additional, Machado, Ausenda, additional, Lazar, Mihaela, additional, Buesa, Itziar Casado, additional, Dürrwald, Ralf, additional, Werf, Sylvie van der, additional, O'Donnell, Joan, additional, Dopido, Juan Antonio Linares, additional, Meijer, Adam, additional, Riess, Maximilian, additional, Vučina, Vesna Višekruna, additional, Rodrigues, Ana Paula, additional, Mihai, Maria Elena, additional, Castilla, Jesus, additional, Goerlitz, Luise, additional, Falchi, Alessandra, additional, Connell, Jeff, additional, Castrillejo, Daniel, additional, Hooiveld, Mariette, additional, Carnahan, AnnaSara, additional, Ilić, Maja, additional, Guiomar, Raquel, additional, Ivanciuc, Alina-Elena, additional, Maurel, Marine, additional, Omokanye, Ajibol, additional, and Valenciano, Marta, additional

Published
2022
Full Text
View/download PDF

44. Effectiveness of 10 and 13-valent pneumococcal conjugate vaccines against invasive pneumococcal disease in European children: SpIDnet observational multicentre study

Author

Savulescu, Camelia, primary, Krizova, Pavla, additional, Valentiner-Branth, Palle, additional, Ladhani, Shamez, additional, Rinta-Kokko, Hanna, additional, Levy, Corinne, additional, Mereckiene, Jolita, additional, Knol, Mirjam, additional, Winje, Brita A., additional, Ciruela, Pilar, additional, de Miguel, Sara, additional, Guevara, Marcela, additional, MacDonald, Laura, additional, Kozakova, Jana, additional, Slotved, Hans-Christian, additional, Fry, Norman K., additional, Pekka Nuorti, J., additional, Danis, Kostas, additional, Corcoran, Mary, additional, van der Ende, Arie, additional, Vestrheim, Didrik F., additional, Munoz-Almagro, Carmen, additional, Sanz, Juan-Carlos, additional, Castilla, Jesus, additional, Smith, Andrew, additional, Colzani, Edoardo, additional, Pastore Celentano, Lucia, additional, and Hanquet, Germaine, additional

Published
2022
Full Text
View/download PDF

47. Influenza Vaccine Effectiveness in Preventing Outpatient, Inpatient, and Severe Cases of Laboratory-Confirmed Influenza

Author

CIBERESP Cases and Controls in Influenza Working Group Spain, Castilla, Jesús, Godoy, Pere, Domínguez, Ángela, Martínez-Baz, Iván, Astray, Jenaro, Martín, Vicente, Delgado-Rodríguez, Miguel, Baricot, Maretva, Soldevila, Nuria, Mayoral, José María, Quintana, José María, Galán, Juan Carlos, Castro, Ady, González-Candelas, Fernando, Garín, Olatz, Saez, Marc, Tamames, Sonia, and Pumarola, Tomás

Published
2013
Full Text
View/download PDF

48. Pre-Diagnostic Circulating Resistin Concentrations Are Not Associated with Colorectal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition Study

Author

Thu-Thi Pham, Nimptsch, Katharina, Aleksandrova, Krasimira, Jenab, Mazda, Reichmann, Robin, Wu, Kana, Tjonneland, Anne, Kyro, Cecilie, Schulze, Matthias B., Kaaks, Rudolf, Katzke, Verena, Palli, Domenico, Pasanisi, Fabrizio, Ricceri, Fulvio, Tumino, Rosario, Krogh, Vittorio, Roodhart, Jeanine, Castilla, Jesus, Sanchez, Maria-Jose, Colorado-Yohar, Sandra Milena, Harbs, Justin, Rutegard, Martin, Papier, Keren, Aglago, Elom K., Dimou, Niki, Mayen-Chacon, Ana-Lucia, Weiderpass, Elisabete, Pischon, Tobias, Thu-Thi Pham, Nimptsch, Katharina, Aleksandrova, Krasimira, Jenab, Mazda, Reichmann, Robin, Wu, Kana, Tjonneland, Anne, Kyro, Cecilie, Schulze, Matthias B., Kaaks, Rudolf, Katzke, Verena, Palli, Domenico, Pasanisi, Fabrizio, Ricceri, Fulvio, Tumino, Rosario, Krogh, Vittorio, Roodhart, Jeanine, Castilla, Jesus, Sanchez, Maria-Jose, Colorado-Yohar, Sandra Milena, Harbs, Justin, Rutegard, Martin, Papier, Keren, Aglago, Elom K., Dimou, Niki, Mayen-Chacon, Ana-Lucia, Weiderpass, Elisabete, and Pischon, Tobias

Abstract

Simple Summary Resistin has been proposed to link to cancer development via inflammatory processes. Prior case-control studies suggest higher post-diagnosis resistin concentrations in CRC cases compared to controls. Here, we found no association between pre-diagnostic circulating resistin concentrations and the risk of CRC; however, we observed a marginally significant association among cases (and their matched controls) diagnosed with CRC within the first two years of follow-up, whereas no such association was observed among cases (and their matched controls) diagnosed with CRC after two years of follow-up. We speculate that resistin is more likely a marker of existing tumors than a risk factor of CRC. Resistin is a polypeptide implicated in inflammatory processes, and as such could be linked to colorectal carcinogenesis. In case-control studies, higher resistin levels have been found in colorectal cancer (CRC) patients compared to healthy individuals. However, evidence for the association between pre-diagnostic resistin and CRC risk is scarce. We investigated pre-diagnostic resistin concentrations and CRC risk within the European Prospective Investigation into Cancer and Nutrition using a nested case-control study among 1293 incident CRC-diagnosed cases and 1293 incidence density-matched controls. Conditional logistic regression models controlled for matching factors (age, sex, study center, fasting status, and women-related factors in women) and potential confounders (education, dietary and lifestyle factors, body mass index (BMI), BMI-adjusted waist circumference residuals) were used to estimate relative risks (RRs) and 95% confidence intervals (CIs) for CRC. Higher circulating resistin concentrations were not associated with CRC (RR per doubling resistin, 1.11; 95% CI 0.94-1.30; p = 0.22). There were also no associations with CRC subgroups defined by tumor subsite or sex. However, resistin was marginally associated with a higher CRC risk among participants f

Published
2022

Catalog

Books, media, physical & digital resources
See catalog results