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7. Harmonization of sensorimotor deficit assessment in a registered multicentre pre-clinical randomized controlled trial using two models of ischemic stroke

Author

Valente, Alessia, Mariani, Jacopo, Seminara, Serena, Tettamanti, Mauro, Pignataro, Giuseppe, Perego, Carlo, Sironi, Luigi, Pedata, Felicita, Amantea, Diana, Bacigaluppi, Marco, Vinciguerra, Antonio, Diamanti, Susanna, Viganò, Martina, Santangelo, Francesco, Zoia, Chiara Paola, Rodriguez-Menendez, Virginia, Castiglioni, Laura, Rzemieniec, Joanna, Dettori, Ilaria, Bulli, Irene, Coppi, Elisabetta, Di Santo, Chiara, Cuomo, Ornella, Gullotta, Giorgia Serena, Butti, Erica, Bagetta, Giacinto, Martino, Gianvito, De Simoni, Maria-Grazia, Ferrarese, Carlo, Fumagalli, Stefano, and Beretta, Simone

Published
2023
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9. Do Temporary Dropouts Improve the Composition of Panel Data? An Analysis of 'Gap Interviews' in the German Family Panel pairfam

Author

Müller, Bettina and Castiglioni, Laura

Abstract

In the context of cross-sectional surveys, the scope of research on the impact of response enhancing strategies on sample composition and nonresponse bias is vast. This topic has rarely been addressed for panel studies, however, although these are becoming an increasingly important data source in social research. In this article, we evaluate the impact of reissuing wave nonrespondents on sample composition and survey estimates in the German Family Panel pairfam. In light of concerns about an adequate representation of life changes in panel studies, we focus on whether temporary dropouts improve sample composition in this respect: Using retrospective information from these cases provided at reentry, we approximate the impact of "lost" reports of life changes due to attrition. Our analysis reveals that the inclusion of temporary dropouts does increase sample variability regarding life changes. However, example analyses indicate that substantive conclusions would not be compromised if temporary dropouts were excluded.

Published
2020
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11. Towards bio-compatible magnetic nanoparticles: Immune-related effects, in-vitro internalization, and in-vivo bio-distribution of zwitterionic ferrite nanoparticles with unexpected renal clearance

Author

Ferretti, Anna M., Usseglio, Sandro, Mondini, Sara, Drago, Carmelo, La Mattina, Rosa, Chini, Bice, Verderio, Claudia, Leonzino, Marianna, Cagnoli, Cinzia, Joshi, Pooja, Boraschi, Diana, Italiani, Paola, Li, Yang, Swartzwelter, Benjamin J., Sironi, Luigi, Gelosa, Paolo, Castiglioni, Laura, Guerrini, Uliano, and Ponti, Alessandro

Published
2021
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15. Attrition im Beziehungs- und Familienpanel pairfam

Author

Müller, Bettina, Castiglioni, Laura, Faulbaum, Frank, Series editor, Hill, Paul, Series editor, Pfau-Effinger, Birgit, Series editor, Schupp, Jürgen, Series editor, Stahl, Matthias, Series editor, and Wolf, Christof, Series editor

Published
2015
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16. Risk of parenterally transmitted hepatitis following exposure to invasive procedures in Italy: SEIEVA surveillance 2000-2021

Author

Caminada, Susanna, primary, Mele, Annamaria, additional, Ferrigno, Luigina, additional, Alfonsi, Valeria, additional, Crateri, Simonetta, additional, Iantosca, Giuseppina, additional, Sabato, Marise, additional, Tosti, Maria Elena, additional, D’Angelo, Franca, additional, Zotti, Carla, additional, Marengo, Noemi, additional, Cornio, Alessandro Roberto, additional, Russotto, Antonino, additional, Scarvaglieri, Maria Elisabetta, additional, Gallone, Angela, additional, Zoia, Irene, additional, Torchio, Pierfederico, additional, Melcarne, Lucia, additional, Castagno, Paolo, additional, Bassetti, Saveria, additional, Dama, Erika, additional, Orlandi, Silvia, additional, Busso, Stefania, additional, Andreoletti, Michela, additional, Fontana, Manuela, additional, Rametta, Stefania, additional, Cranco, Rosita, additional, Bonacina, Alessandra, additional, Lioce, Duilio, additional, Ciprioti, Rosamary, additional, Cappello, Maria Teresa, additional, Palma, Anna Maria, additional, Musso, Claudia, additional, Bussolino, Paola, additional, Smaniotto, Alessandro, additional, Ruffier, Mario, additional, Verardo, Marina, additional, Cipriani, Alessandro, additional, Cereda, Danilo, additional, Senatore, Sabrina, additional, Donadini, Annalisa, additional, Nespoli, Carla, additional, Gennati, Giorgio, additional, Piro, Antonio, additional, Vezzosi, Luigi, additional, Conca, Matteo, additional, Romani, Michela, additional, Tortorella, Franco Paolo, additional, Merlini, Paola Elvira, additional, Di Caterina, Davide, additional, Faccini, Marino, additional, Lamberti, Anna, additional, Rossetti, Eva, additional, Brugnoli, Rita, additional, Mainardi, Giulia, additional, Vezzoli, Alessandra, additional, Caso, Daniela, additional, Testa, Milena, additional, Costa, Daniela, additional, Senegaglia, Paola, additional, Spagna, Annamaria, additional, Lodola, Silvia, additional, Riboli, Simona, additional, Giompapa, Enza, additional, Roveri, Luigi Guido, additional, Guardigli, Gabriele, additional, Scalvinoni, Vanna, additional, Lombarda, Elena, additional, Gasparri, Serena, additional, Spertini, Silvia, additional, Gamper, Sabine, additional, Moretto, Giacomo, additional, Kofler, Elisabeth, additional, Ploner, Barbara, additional, Runggatscher, Verena, additional, Molinaro, Silvia, additional, Zuccali, Maria Grazia, additional, Franchini, Silvia, additional, Russo, Francesca, additional, Zanella, Francesca, additional, Ballarin, Debora, additional, Fiorito, Nahuel, additional, Zallot, Chiara, additional, Cian, Serena, additional, Bonsembiante, Erminio, additional, Mattiuzzo, Elena, additional, Munarin, Ludovica, additional, Palazzi, Barbara, additional, Sulaj, Arda, additional, Boin, Federica, additional, Carraro, Daniele, additional, Codolo, Antonella, additional, Fragapane, Marilena, additional, Formaglio, Andrea, additional, Giacobbe, Donatella, additional, Fenzi, Federica, additional, Gottardello, Lorena, additional, Cannizzo, Elisabetta, additional, Ceccon, Giulia, additional, De Stefani, Emanuela, additional, Casagrande, Paola, additional, Zotto, Alessandra Dal, additional, Zotto, Rita Dal, additional, Carlotto, Antonio, additional, Zorzi, Gemma, additional, Ivanovska, Sandra, additional, Postiglione, Chiara, additional, Colucci, Laura, additional, Rocco, Giulio, additional, Stacul, Rossana, additional, Breda, Ariella, additional, Bortolossi, Marisa, additional, Iob, Andrea, additional, Micossi, Simonetta, additional, Feltrin, Oriana, additional, Caernelos, Giuseppina, additional, Mela, Marco, additional, Frumento, Virna, additional, Opisso, Anna, additional, Cuccu, Alessandro, additional, Carpi, Antonella, additional, Giuffra, Paola, additional, Torracca, Francesca, additional, Castiglioni, Laura, additional, Mattei, Giovanna, additional, Gualanduzzi, Claudio, additional, Massimiliani, Erika, additional, Rampini, Alessandra, additional, Paglioli, Silvia, additional, Bisaccia, Eufemia, additional, Roversi, Sandra, additional, Resi, Davide, additional, Prengka, Anna, additional, Califano, Annalisa, additional, Santoro, Viviana, additional, Biguzzi, Emilia, additional, Reali, Chiara, additional, Morri, Michela, additional, Senatore, Daniela, additional, Balocchini, Emanuela, additional, Pierozzi, Costanza, additional, Angio, Francesco, additional, Kundisova, Lucia, additional, Isola, Alda, additional, Cecconi, Rossella, additional, Berti, Cristiana, additional, Matarazzo, Francesca, additional, Zini, Paola, additional, Staderini, Chiara, additional, Cordella, Vincenzo, additional, Brugnoli, Sara, additional, Sacchelli, Francesco, additional, Lucchesi, Lara, additional, Luzzoli, Rosa, additional, Gandolfo, Silvia, additional, Cibeca, Piero, additional, Galletti, Nicoletta, additional, Aquino, Francesco, additional, Lari, Maria, additional, Poropat, Roberta, additional, Ferrini, Rita, additional, Barbieri, Alessandro, additional, Conti, Vito, additional, Canale, Alice, additional, Moretti, Katia, additional, Buccino, Aniello, additional, Bartoli, Ilaria, additional, Cioni, Silvia, additional, Gennari, Giulia, additional, Rapaccini, Fabiola, additional, Bekshiu, Lumturi, additional, Zacchini, Federica, additional, Romani, Davide, additional, Sansone, Monica, additional, Foresi, Simona, additional, Piattellini, Giovanni, additional, Pasquale, Anna, additional, Brancaleoni, Maria Grazia, additional, Santocchia, Franco, additional, Proietti, Maria Laura, additional, Fiacchini, Daniel, additional, Giamprini, Maria Sole, additional, Iacobellis, Mariangela, additional, Van Will, Jacqueline, additional, Vaccaro, Alfredo, additional, Sbarbati, Maria Margherita, additional, Amelio, Alessandra, additional, Cimini, Daniela, additional, Moroni, Vania, additional, Francoletti, Daniela, additional, Marcellini, Mirella, additional, Scaccia, Federica, additional, Branchesi, Elisabetta, additional, Saracino, Selena, additional, Mezzanotte, Catia, additional, Cimica, Susanna, additional, Vitale, Vita, additional, Laici, Franca, additional, Petrelli, Irene, additional, Airini, Barbara, additional, Passarini, Gabriella, additional, Ruffini, Lucia, additional, Lambertucci, Anna Maria, additional, Mogetta, Annarita, additional, Ciarrocchi, Giuseppe, additional, Pistolesi, Marina, additional, Fratello, Erika, additional, Picciotti, Francesca, additional, Contrisciani, Roberta, additional, Angelini, Claudio, additional, Ribiscini, Silvia, additional, Scognamiglio, Paola, additional, Vairo, Francesco, additional, De Santis, Claudia, additional, Miglietta, Antonio Salvatore, additional, Colosi, Alberto, additional, Loffredo, Maria Rosaria, additional, Esterini, Giorgio, additional, Pendenza, Alessio, additional, Nappi, Maria Rosaria, additional, Casagni, Luca, additional, Santucci, Luigi, additional, Montecchi, Margherita, additional, Mangiagli, Franca, additional, Aquilani, Silvia, additional, Di Luzio, Giuseppe, additional, Provvidenti, Luca, additional, Giambi, Cristina, additional, Di Giacomo, Manuela, additional, Giansanti, Enrico, additional, Mancini, Cristiana, additional, Turchi, Claudio, additional, Soldato, Graziella, additional, D'Eugenio, Felesina, additional, Albanesi, Ida, additional, Montanaro, Carmen, additional, Di Giorgio, Giovanni, additional, Prozzo, Alessandra, additional, Sabatini, Paola, additional, Simonelli, Mena, additional, Morrone, Gaetano, additional, Citarella, Annarita, additional, Fossi, Elena, additional, Alfieri, Rosa, additional, Scotto, Milena, additional, Caiazzo, Anna Luisa, additional, Liquori, Antonia, additional, Chironna, Maria, additional, Prato, Rosa, additional, Martinelli, Domenico, additional, Fortunato, Francesca, additional, Cappelli, Maria Giovanna, additional, Loconsole, Daniela, additional, Morea, Anna, additional, Del Matto, Giulia, additional, Maluccio, Maria Giuseppina, additional, Pedote, Pasquale, additional, Termite, Stefano, additional, Cambria, Roberta, additional, Caputi, Giovanni, additional, Cipriani, Rosati, additional, Desiante, Francesco, additional, Menolascina, Stefania, additional, Laforgia, Vera, additional, Squicciarini, Rosella, additional, Vitale, Viviana, additional, Matera, Anna Maria, additional, Pagone, Onofrio, additional, Avella, Grazia Maria, additional, Madaro, Antonino, additional, Angelillis, Raffaele, additional, Moffa, Giuseppina, additional, Nesta, Maria, additional, De Santis, Carlo, additional, Ferraro, Marisa, additional, Aprile, Valerio, additional, Antonazzo, Marcello, additional, Laugello, Giovanni, additional, Mignuoli, Anna Domenica, additional, Afflitto, Giuseppe, additional, Caroleo, Benedetto, additional, Scrivano, Francesca, additional, Maradei, Antonio, additional, Romeo, Rocco Cataldo, additional, Zucco, Rossella, additional, Coscarelli, Pierluigi, additional, Bisbano, Alessandro, additional, Monesanti, Maria, additional, De Giorgio, Vincenzo, additional, Giordano, Antonella, additional, Mammì, Pier Domenico, additional, Lazzarino, Elisa, additional, Surace, Vittoria, additional, Mangione, Rossana, additional, Meli, Valentina, additional, Cuccia, Mario, additional, Longhitano, Elena, additional, Delogu, Fiorenzo, additional, Fracasso, Donatella, additional, Marceddu, Maria Vittoria, additional, Flore, Loredana, additional, Eugenia Marras, Maria Valentina, additional, Serpi, Rita, additional, Campus, Marco, additional, and Raggio, Alessia, additional

Published
2023
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18. sj-pdf-1-jcb-10.1177_0271678X231159958 - Supplemental material for Harmonization of sensorimotor deficit assessment in a registered multicentre pre-clinical randomized controlled trial using two models of ischemic stroke

Author

Valente, Alessia, Mariani, Jacopo, Seminara, Serena, Tettamanti, Mauro, Pignataro, Giuseppe, Perego, Carlo, Sironi, Luigi, Pedata, Felicita, Amantea, Diana, Bacigaluppi, Marco, Vinciguerra, Antonio, Diamanti, Susanna, Viganò, Martina, Santangelo, Francesco, Zoia, Chiara Paola, Rodriguez-Menendez, Virginia, Castiglioni, Laura, Rzemieniec, Joanna, Dettori, Ilaria, Bulli, Irene, Coppi, Elisabetta, Di Santo, Chiara, Cuomo, Ornella, Gullotta, Giorgia Serena, Butti, Erica, Bagetta, Giacinto, Martino, Gianvito, De Simoni, Maria-Grazia, Ferrarese, Carlo, Fumagalli, Stefano, and Beretta, Simone

Subjects
110320 Radiology and Organ Imaging, FOS: Clinical medicine, FOS: Biological sciences, Medicine, Cell Biology, 110305 Emergency Medicine, 110306 Endocrinology, Biochemistry, 69999 Biological Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-pdf-1-jcb-10.1177_0271678X231159958 for Harmonization of sensorimotor deficit assessment in a registered multicentre pre-clinical randomized controlled trial using two models of ischemic stroke by Alessia Valente, Jacopo Mariani, Serena Seminara, Mauro Tettamanti, Giuseppe Pignataro, Carlo Perego, Luigi Sironi, Felicita Pedata, Diana Amantea, Marco Bacigaluppi, Antonio Vinciguerra, Susanna Diamanti, Martina Viganò, Francesco Santangelo, Chiara Paola Zoia, Virginia Rodriguez-Menendez, Laura Castiglioni, Joanna Rzemieniec, Ilaria Dettori, Irene Bulli, Elisabetta Coppi, Chiara Di Santo, Ornella Cuomo, Giorgia Serena Gullotta, Erica Butti, Giacinto Bagetta, Gianvito Martino, Maria-Grazia De Simoni, Carlo Ferrarese, Stefano Fumagalli, Simone Beretta and for the TRICS study group in Journal of Cerebral Blood Flow & Metabolism

Published
2023
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19. Resolving relationship dissolution—What predicts emotional adjustment after breakup?

Author

Tran, Kien, Castiglioni, Laura, Walper, Sabine, and Lux, Ulrike

Abstract

Relationship dissolution is a critical life event individuals have to cope with. Factors like relationship duration and relationship quality or having a new partner are likely to affect how people recover emotionally from a separation, which is linked to long‐term adjustment. However, prospective evidence on the role of these factors is scarce. Hence, this study aims to investigate predictors of emotional recovery following relationship dissolution. Pooled data of the German Family Panel pairfam on 3734 separation events of 2709 individuals aged 18 to 48 were used, applying a statistical model called seemingly unrelated regressions to predict emotional outcomes (relief, anger, guilt, and sadness) and the general emotional state regarding separation. Sociodemographic and relationship characteristics, indicators of relationship quality, conditions of the separation, and features of the current situation were considered as potential predictors. Regression analyses evidence strong links of initiator status, having a new partner, time since separation, and satisfaction with the social network to less negative emotional outcomes following separation. Relationship quality or serious problems before the separation only affected some of the investigated emotional outcomes. Interestingly, the predictors investigated were less powerful in explaining respondents' feelings of guilt compared to the other emotions. Overall, these findings provide deeper insight into short‐term adjustment to separation. Understanding these processes may help to assess risk factors for negative coping mechanisms and improve tailored counseling strategies. [ABSTRACT FROM AUTHOR]

Published
2023
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25. Left ventricular mass and cardiac function in a population of children with chronic kidney disease

Author

Mencarelli, Francesca, Fabi, Marianna, Corazzi, Valentina, Doyon, Anke, Masetti, Riccardo, Bonetti, Simone, Castiglioni, Laura, Pession, Andrea, and Montini, Giovanni

Subjects
Chronic kidney failure -- Complications and side effects -- Prognosis -- Research, Cardiovascular diseases -- Risk factors -- Development and progression -- Diagnosis -- Research, Health
Abstract

Background Cardiovascular disease (CVD) is a common cause of morbidity and mortality in children with chronic kidney disease (CKD). Left ventricular hypertrophy (LVH) and diastolic dysfunction (LVDD) are early markers. The aims of this study were to evaluate (1) LVH and LVDD, using both conventional echocardiographic evaluation and Tissue Doppler Imaging (TDI), and (2) the correlation between cardiac disease and possible risk factors, in children with CKD. Methods The study cohort comprised 34 paediatric patients with CKD and 34 healthy children (mean ± standard deviation: age 9 ± 4.6 and 8.2 ± 4.3 years, respectively). Thirteen (38 %) patients were in CKD stage 2, 15 (44 %) in stage 3 and six (18 %) in stage 4-5. LVH was defined as a left ventricular mass index (LVMI) of >95th percentile (38 g/[h.sup.2.7]). Results Left ventricular hypertrophy was present in 13 patients (38 %). Diastolic function evaluated with TDI (E'/A' = early/late diastolic myocardial velocity) worsened with the reduction of glomerular filtration rate (p = 0.020). There was a positive correlation between LVMI and body mass index-standard deviation score (p = 0.020) and a negative correlation between E'/A' and serum phosphorus and calcium levels and their respective product (p = 0.004, p = 0.017, p < 0.001). The relaxation index E' was reduced in 68 % of patients. Conclusion Based on our results, TDI is a simple procedure and would appear to be a more accurate diagnostic tool than conventional echocardiography in the early diagnosis of LVDD. Keywords Chronic kidney disease * Children * Cardiovascular disease * Left ventricular mass * Diastolic function * Tissue Doppler imaging, Introduction The lifespan of a paediatric patient on dialysis is shortened by 50 years compared with control individuals matched for age and ethnicity. Even after successful transplantation, the lifespan of [...]

Published
2014
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27. PCSK9 deficiency rewires heart metabolism and drives heart failure with preserved ejection fraction

Author

Da Dalt, Lorenzo, primary, Castiglioni, Laura, additional, Baragetti, Andrea, additional, Audano, Matteo, additional, Svecla, Monika, additional, Bonacina, Fabrizia, additional, Pedretti, Silvia, additional, Uboldi, Patrizia, additional, Benzoni, Patrizia, additional, Giannetti, Federica, additional, Barbuti, Andrea, additional, Pellegatta, Fabio, additional, Indino, Serena, additional, Donetti, Elena, additional, Sironi, Luigi, additional, Mitro, Nico, additional, Catapano, Alberico Luigi, additional, and Norata, Giuseppe Danilo, additional

Published
2021
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30. Online_Appendix - Do Temporary Dropouts Improve the Composition of Panel Data? An Analysis of 'Gap Interviews' in the German Family Panel pairfam

Author

Müller, Bettina and Castiglioni, Laura

Subjects
Sociology, 160807 Sociological Methodology and Research Methods, FOS: Sociology
Abstract

Online_Appendix for Do Temporary Dropouts Improve the Composition of Panel Data? An Analysis of “Gap Interviews” in the German Family Panel pairfam by Bettina Müller and Laura Castiglioni in Sociological Methods & Research

Published
2020
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31. Multicentre translational Trial of Remote Ischaemic Conditioning in Acute Ischaemic Stroke (TRICS): protocol of multicentre, parallel group, randomised, preclinical trial in female and male rat and mouse from the Italian Stroke Organization (ISO) Basic Science networkMulticentre translational Trial of Remote Ischaemic Conditioning in Acute Ischaemic Stroke (TRICS): protocol of multicentre, parallel group, randomised, preclinical trial in female and male rat and mouse from the Italian Stroke Organization (ISO) Basic Science network

Author

Tettamanti, Mauro, primary, Beretta, Simone, additional, Pignataro, Giuseppe, additional, Fumagalli, Stefano, additional, Perego, Carlo, additional, Sironi, Luigi, additional, Pedata, Felicita, additional, Amantea, Diana, additional, Bacigaluppi, Marco, additional, Vinciguerra, Antonio, additional, Valente, Alessia, additional, Diamanti, Susanna, additional, Mariani, Jacopo, additional, Viganò, Martina, additional, Santangelo, Francesco, additional, Zoia, Chiara Paola, additional, Rogriguez-Menendez, Virginia, additional, Castiglioni, Laura, additional, Rzemieniec, Joanna, additional, Dettori, Ilaria, additional, Bulli, Irene, additional, Coppi, Elisabetta, additional, Gullotta, Giorgia Serena, additional, Bagetta, Giacinto, additional, Martino, Gianvito, additional, Ferrarese, Carlo, additional, and De Simoni, Maria Grazia, additional

Published
2020
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34. Impact of BDNF Val66Met Polymorphism on Myocardial Infarction: Exploring the Macrophage Phenotype

Author

Sandrini, Leonardo, primary, Castiglioni, Laura, additional, Amadio, Patrizia, additional, Werba, José Pablo, additional, Eligini, Sonia, additional, Fiorelli, Susanna, additional, Zarà, Marta, additional, Castiglioni, Silvia, additional, Bellosta, Stefano, additional, Lee, Francis S., additional, Sironi, Luigi, additional, Tremoli, Elena, additional, and Barbieri, Silvia Stella, additional

Published
2020
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35. PCSK9 deficiency rewires heart metabolism and drives heart failure with preserved ejection fraction.

Author

Dalt, Lorenzo Da, Castiglioni, Laura, Baragetti, Andrea, Audano, Matteo, Svecla, Monika, Bonacina, Fabrizia, Pedretti, Silvia, Uboldi, Patrizia, Benzoni, Patrizia, Giannetti, Federica, Barbuti, Andrea, Pellegatta, Fabio, Indino, Serena, Donetti, Elena, Sironi, Luigi, Mitro, Nico, Catapano, Alberico Luigi, and Norata, Giuseppe Danilo

Subjects
LOW density lipoproteins, BLOOD lipoproteins, HEART metabolism, HEART failure, HEART diseases
Abstract

Aims PCSK9 is secreted into the circulation, mainly by the liver, and interacts with low-density lipoprotein receptor (LDLR) homologous and non-homologous receptors, including CD36, thus favouring their intracellular degradation. As PCSK9 deficiency increases the expression of lipids and lipoprotein receptors, thus contributing to cellular lipid accumulation, we investigated whether this could affect heart metabolism and function. Methods and results Wild-type (WT), Pcsk9 KO, Liver conditional Pcsk9 KO and Pcsk9/Ldlr double KO male mice were fed for 20 weeks with a standard fat diet and then exercise resistance, muscle strength, and heart characteristics were evaluated. Pcsk9 KO presented reduced running resistance coupled to echocardiographic abnormalities suggestive of heart failure with preserved ejection fraction (HFpEF). Heart mitochondrial activity, following maximal coupled and uncoupled respiration, was reduced in Pcsk 9 KO mice compared to WT mice and was coupled to major changes in cardiac metabolism together with increased expression of LDLR and CD36 and with lipid accumulation. A similar phenotype was observed in Pcsk9/Ldlr DKO, thus excluding a contribution for LDLR to cardiac impairment observed in Pcsk9 KO mice. Heart function profiling of the liver selective Pcsk9 KO model further excluded the involvement of circulating PCSK9 in the development of HFpEF, pointing to a possible role locally produced PCSK9. Concordantly, carriers of the R46L loss-of-function variant for PCSK9 presented increased left ventricular mass but similar ejection fraction compared to matched control subjects. Conclusion PCSK9 deficiency impacts cardiac lipid metabolism in an LDLR independent manner and contributes to the development of HFpEF. [ABSTRACT FROM AUTHOR]

Published
2021
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36. Improvement of fiber connectivity and functional recovery after stroke by montelukast, an available and safe anti-asthmatic drug

Author

Gelosa, Paolo, primary, Bonfanti, Elisabetta, additional, Castiglioni, Laura, additional, Delgado-Garcia, José Maria, additional, Gruart, Agnès, additional, Fontana, Lucia, additional, Gotti, Marco, additional, Tremoli, Elena, additional, Lecca, Davide, additional, Fumagalli, Marta, additional, Cimino, Mauro, additional, Aigner, Ludwig, additional, Abbracchio, Maria P., additional, and Sironi, Luigi, additional

Published
2019
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37. A Specific Circulating MicroRNA Cluster Is Associated to Late Differential Cardiac Response to Doxorubicin-Induced Cardiotoxicity In Vivo

Author

Ruggeri, Clarissa, primary, Gioffré, Sonia, additional, Chiesa, Mattia, additional, Buzzetti, Marta, additional, Milano, Giuseppina, additional, Scopece, Alessandro, additional, Castiglioni, Laura, additional, Pontremoli, Marta, additional, Sironi, Luigi, additional, Pompilio, Giulio, additional, Colombo, Gualtiero I., additional, and D’Alessandra, Yuri, additional

Published
2018
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38. Cysteinyl Leukotrienes as Potential Pharmacological Targets for Cerebral Diseases

Author

Gelosa, Paolo, Colazzo, Francesca, Tremoli, Elena, Sironi, Luigi, and Castiglioni, Laura

Subjects
Article Subject
Abstract

Cysteinyl leukotrienes (CysLTs) are potent lipid mediators widely known for their actions in asthma and in allergic rhinitis. Accumulating data highlights their involvement in a broader range of inflammation-associated diseases such as cancer, atopic dermatitis, rheumatoid arthritis, and cardiovascular diseases. The reported elevated levels of CysLTs in acute and chronic brain lesions, the association between the genetic polymorphisms in the LTs biosynthesis pathways and the risk of cerebral pathological events, and the evidence from animal models link also CysLTs and brain diseases. This review will give an overview of how far research has gone into the evaluation of the role of CysLTs in the most prevalent neurodegenerative disorders (ischemia, Alzheimer’s and Parkinson’s diseases, multiple sclerosis/experimental autoimmune encephalomyelitis, and epilepsy) in order to understand the underlying mechanism by which they might be central in the disease progression.

Published
2017
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39. Role of the Cysteinyl Leukotrienes in the Pathogenesis and Progression of Cardiovascular Diseases

Author

Colazzo, Francesca, Gelosa, Paolo, Tremoli, Elena, Sironi, Luigi, and Castiglioni, Laura

Subjects
Article Subject
Abstract

Cysteinyl leukotrienes (CysLTs) are potent lipid inflammatory mediators synthesized from arachidonic acid, through the 5-lipoxygenase (5-LO) pathway. Owing to their properties, CysLTs play a crucial role in the pathogenesis of inflammation; therefore, CysLT modifiers as synthesis inhibitors or receptor antagonists, central in asthma management, may become a potential target for the treatment of other inflammatory diseases such as the cardiovascular disorders. 5-LO pathway activation and increased expression of its mediators and receptors are found in cardiovascular diseases. Moreover, the cardioprotective effects observed by using CysLT modifiers are promising and contribute to elucidate the link between CysLTs and cardiovascular disease. The aim of this review is to summarize the state of present research about the role of the CysLTs in the pathogenesis and progression of atherosclerosis and myocardial infarction.

Published
2017
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40. Do Temporary Dropouts Improve the Composition of Panel Data? An Analysis of "Gap Interviews" in the German Family Panel pairfam.

Author

Müller, Bettina and Castiglioni, Laura

Subjects
*SOCIAL science research, *PANEL analysis, *INTERVIEWING, *FAMILIES
Abstract

In the context of cross-sectional surveys, the scope of research on the impact of response enhancing strategies on sample composition and nonresponse bias is vast. This topic has rarely been addressed for panel studies, however, although these are becoming an increasingly important data source in social research. In this article, we evaluate the impact of reissuing wave nonrespondents on sample composition and survey estimates in the German Family Panel pairfam. In light of concerns about an adequate representation of life changes in panel studies, we focus on whether temporary dropouts improve sample composition in this respect: Using retrospective information from these cases provided at reentry, we approximate the impact of "lost" reports of life changes due to attrition. Our analysis reveals that the inclusion of temporary dropouts does increase sample variability regarding life changes. However, example analyses indicate that substantive conclusions would not be compromised if temporary dropouts were excluded. [ABSTRACT FROM AUTHOR]

Published
2020
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43. Fenofibrate attenuates cardiac and renal alterations in young salt-loaded spontaneously hypertensive stroke-prone rats through mitochondrial protection

Author

Castiglioni, Laura, primary, Pignieri, Alice, additional, Fiaschè, Melania, additional, Giudici, Marco, additional, Crestani, Maurizio, additional, Mitro, Nico, additional, Abbate, Mauro, additional, Zoja, Carlamaria, additional, Rottoli, Daniela, additional, Foray, Claudia, additional, Fiordaliso, Fabio, additional, Guerrini, Uliano, additional, Tremoli, Elena, additional, Sironi, Luigi, additional, and Gelosa, Paolo, additional

Published
2018
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46. Pediatric Tuberculosis in Italian Children: Epidemiological and Clinical Data from the Italian Register of Pediatric Tuberculosis

Author

Galli, Luisa, primary, Lancella, Laura, additional, Tersigni, Chiara, additional, Venturini, Elisabetta, additional, Chiappini, Elena, additional, Bergamini, Barbara, additional, Codifava, Margherita, additional, Venturelli, Cristina, additional, Tosetti, Giulia, additional, Marabotto, Caterina, additional, Cursi, Laura, additional, Boccuzzi, Elena, additional, Garazzino, Silvia, additional, Tovo, Pier, additional, Pinon, Michele, additional, Le Serre, Daniele, additional, Castiglioni, Laura, additional, Lo Vecchio, Andrea, additional, Guarino, Alfredo, additional, Bruzzese, Eugenia, additional, Losurdo, Giuseppe, additional, Castagnola, Elio, additional, Bossi, Grazia, additional, Marseglia, Gian, additional, Esposito, Susanna, additional, Bosis, Samantha, additional, Grandolfo, Rita, additional, Fiorito, Valentina, additional, Valentini, Piero, additional, Buonsenso, Danilo, additional, Domenici, Raffaele, additional, Montesanti, Marco, additional, Salvini, Filippo, additional, Riva, Enrica, additional, Dodi, Icilio, additional, Maschio, Francesca, additional, Abbagnato, Luisa, additional, Fiumana, Elisa, additional, Fornabaio, Chiara, additional, Ballista, Patrizia, additional, Portelli, Vincenzo, additional, Bottone, Gabriella, additional, Palladino, Nicola, additional, Valenzise, Mariella, additional, Vecchi, Barbara, additional, Di Gangi, Maria, additional, Lupi, Carla, additional, Villani, Alberto, additional, and de Martino, Maurizio, additional

Published
2016
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48. EVALUATION OF LEFT VENTRICULAR AND ATRIAL-APPENDAGE FUNCTION IN NORMAL AND ISCHEMIC MOUSE MODELS BY CARDIAC IMAGING TECHNIQUES: A PHARMACOLOGICAL VALIDATION

Author

CASTIGLIONI, LAURA

Abstract

Despite progress in diagnosis and treatment lead to a significant reduction of the rate of death attributable to cardiovascular disease (CVD), many efforts must to be done to modify the pathological process and enhance protection. Thus the development of new technologies for diagnosis and novel therapeutic agents is fundamental for clinicians and researcher. In the last decade, murine model had become a useful tool to study CVDs mechanism and to test new pharmacological treatments. Noninvasive imaging technique, specific for laboratory animals, provide the opportunity to image longitudinally the same animal, investigating the follow-up of pathologies and assessing the effect of pharmacological treatments. Aims of this work are to set up an animal model of myocardial infarction (MI) and cardiac imaging (cardiac magnetic resonance imaging and echocardiography) of left ventricle (LV), left atrium (LA) and appendage (LAA) in healthy mice, and then evaluate the global and regional functional-structural changes and remodeling occurring on LV, LA and LAA after MI, with or without pharmacological treatment. The in vivo imaging data were supported by morphological, histological and gene expression analysis. Results from this study described the regional area changes occurring on LV after MI with a progressive loss of contractility also in remote non-infarcted tissue; the presence of only three pulmonary veins entering LA and the presence of the large LAA which, working together with LA, plays an important role in LV filling. After MI not only LV but also LA and LAA remodel in order to maintain, with their enlargement, LV stroke volume. The pharmacological treatment with valsartan, a selective inhibitor of AT1 receptor of Ang II, influenced LV remodeling by reducing LV enlargement, infarct size, ECM gene expression (in particular collagen VIII, fibulin-2 involved in fibrosis and hypertrophy), preserving LV SV without affecting LAA and LA increase in dimension.

Published
2013
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49. Fenofibrate attenuates cardiac and renal alterations in young salt-loaded spontaneously hypertensive stroke-prone rats through mitochondrial protection.

Author

Castiglionia, Laura, Pignieria, Alice, Fiascheà, Melania, Giudici, Marco, Crestani, Maurizio, Mitro, Nico, Abbate, Mauro, Zoja, Carlamaria, Rottoli, Daniela, Foray, Claudia, Fiordaliso, Fabio, Guerrini, Uliano, Tremoli, Elena, Sironi, Luigi, Gelosa, Paolo, Castiglioni, Laura, Pignieri, Alice, and Fiaschè, Melania

Published
2018
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50. Der Einfluss der Beziehungsqualität auf die Teilnahme sekundärer Respondenten: Ergebnisse mit dem Beziehungs- und Familienpanel

Author

Schröder, Jette, Castiglioni, Laura, Brüderl, Josef, and Krieger, Ulrich

Subjects
Familiensoziologie, Sexualsoziologie, Familiensituation, family, descriptive study, empirical social research, deskriptive Studie, social relations, Antwortverhalten, Sociology & anthropology, soziale Beziehungen, family socialization, family situation, empirische Forschung, response behavior, Social sciences, sociology, anthropology, empirische Sozialforschung, Erhebungstechniken und Analysetechniken der Sozialwissenschaften, Sozialwissenschaften, Soziologie, empirical research, Methods and Techniques of Data Collection and Data Analysis, Statistical Methods, Computer Methods, familiale Sozialisation, Soziologie, Anthropologie, Familie, ddc:300, Family Sociology, Sociology of Sexual Behavior, ddc:301
Abstract

"Die pairfam-Studie bietet die seltene Möglichkeit, dyadische Analysen von Partner- sowie Eltern-Kind-Beziehungen durchzuführen. Es werden im Rahmen der Studie nämlich nicht nur die zufällig gezogenen Ankerpersonen befragt, sondern - mit Zustimmung der Ankerpersonen - auch deren Partner, Eltern und Kinder. Allerdings stellt sich die Frage, ob bzw. inwieweit die Teilnahme der sekundären Respondenten selektiv ist, also die dyadischen Daten durch einen Nonresponse-Bias verzerrt sind. Dieser Beitrag analysiert, welche Faktoren die Teilnahme der Partner und Eltern der Ankerperson am Beziehungs- und Familienpanel pairfam beeinflussen. Im Mittelpunkt steht dabei die Frage, ob die Qualität der Beziehung zwischen Anker und Partner bzw. Anker und Elternteil einen Einfluss auf die Teilnahme hat. Bei den Eltern zeigt sich sowohl ein Einfluss der Beziehungsqualität im engeren Sinne als auch ein Einfluss der Dichte der Beziehung im Hinblick auf Kontakt und gegenseitige Unterstützung. Für die Teilnahme der Partner scheint die Beziehungsqualität hingegen eine geringere Bedeutung zu haben, einen großen Einfluss hat aber der Institutionalisierungsgrad der Beziehung. Der Beitrag möchte pairfam-Nutzer für die Möglichkeit eines Nonresponse-Bias bei dyadischen Analysen sensibilisieren und gibt Hinweise zum angemessenen Umgang mit den Daten." (Autorenreferat)

Published
2012

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