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5. Plasma Transthyretin and Its Ligands

Author

Franzini, Maria, Sanguinetti, Chiara, Musetti, Veronica, Castiglione, Vincenzo, Aimo, Alberto, Vergaro, Giuseppe, Emdin, Michele, Emdin, Michele, editor, Vergaro, Giuseppe, editor, Aimo, Alberto, editor, and Fontana, Marianna, editor

Published
2024
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7. Effects of sacubitril-valsartan on remodelling, fibrosis and mitochondria in a murine model of isoproterenol-induced left ventricular dysfunction

Author

Vergaro, Giuseppe, Del Franco, Annamaria, Carecci, Alessandro, Ferrari Chen, Yu Fu, Aimo, Alberto, Forini, Francesca, Nicolini, Giuseppina, Kusmic, Claudia, Faita, Francesco, Castiglione, Vincenzo, De Tata, Vincenzo, Pucci, Angela, Musetti, Veronica, Burchielli, Silvia, Passino, Claudio, and Emdin, Michele

Published
2024
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8. Valve disease in cardiac amyloidosis: an echocardiographic score

Author

Aimo, Alberto, Fabiani, Iacopo, Maccarana, Agnese, Vergaro, Giuseppe, Chubuchny, Vladyslav, Pasanisi, Emilio Maria, Petersen, Christina, Poggianti, Elisa, Giannoni, Alberto, Spini, Valentina, Taddei, Claudia, Castiglione, Vincenzo, Passino, Claudio, Fontana, Marianna, Emdin, Michele, and Venneri, Lucia

Published
2023
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13. Right heart failure in left heart disease: imaging, functional, and biochemical aspects of right ventricular dysfunction

Author

Ghio, Stefano, Acquaro, Mauro, Agostoni, Piergiuseppe, Ambrosio, Giuseppe, Carluccio, Erberto, Castiglione, Vincenzo, Colombo, Davide, D’Alto, Michele, Delle Grottaglie, Santo, Dini, Frank Lloyd, Emdin, Michele, Fortunato, Martino, Guaricci, Andrea Igoren, Jacoangeli, Francesca, Marra, Alberto M., Paolillo, Stefania, Papa, Sivia, Scajola, Luca Vicini, Correale, Michele, and Palazzuoli, Alberto

Published
2023
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14. Left Ventricular Diastolic Dysfunction

Author

Castiglione, Vincenzo, Gentile, Francesco, Aimo, Alberto, Emdin, Michele, Mancia, Giuseppe, Series Editor, Agabiti-Rosei, Enrico, Series Editor, Dorobantu, Maria, editor, Voicu, Victor, editor, and Grassi, Guido, editor

Published
2023
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24. Prevalence and clinical outcomes of isolated or combined moderate to severe mitral and tricuspid regurgitation in patients with cardiac amyloidosis

Author

Tomasoni, Daniela, primary, Aimo, Alberto, additional, Porcari, Aldostefano, additional, Bonfioli, Giovanni Battista, additional, Castiglione, Vincenzo, additional, Saro, Riccardo, additional, Di Pasquale, Mattia, additional, Franzini, Maria, additional, Fabiani, Iacopo, additional, Lombardi, Carlo Mario, additional, Lupi, Laura, additional, Mazzotta, Marta, additional, Nardi, Matilde, additional, Pagnesi, Matteo, additional, Panichella, Giorgia, additional, Rossi, Maddalena, additional, Vergaro, Giuseppe, additional, Merlo, Marco, additional, Sinagra, Gianfranco, additional, Emdin, Michele, additional, Metra, Marco, additional, and Adamo, Marianna, additional

Published
2024
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26. Characterization of Phenotypic Variability in Becker Muscular Dystrophy for Clinical Practice and Towards Trial Readiness: A Two-Years Follow up Study

Author

Ricci, Giulia, primary, Govoni, Alessandra, additional, Torri, Francesca, additional, Astrea, Guja, additional, Buchignani, Bianca, additional, Marinella, Gemma, additional, Battini, Roberta, additional, Manca, Maria Laura, additional, Castiglione, Vincenzo, additional, Giannoni, Alberto, additional, Emdin, Michele, additional, and Siciliano, Gabriele, additional

Published
2024
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33. Patient-reported outcome measures for transthyretin cardiac amyloidosis: the ITALY study.

Author

Aimo, Alberto, Teresi, Lucio, Castiglione, Vincenzo, Picerni, Anna Lisa, Niccolai, Martina, Severino, Silvia, Agazio, Assunta, Carnevale Baraglia, Anna, Obici, Laura, Palladini, Giovanni, Ponti, Lucia, Argirò, Alessia, Cappelli, Francesco, Perfetto, Federico, Serenelli, Matteo, Trimarchi, Giancarlo, Licordari, Roberto, Di Bella, Gianluca, Chubuchna, Olena, and Quattrone, Filippo

Subjects
CARDIAC amyloidosis, TRANSTHYRETIN, BETA (Finance)
Abstract

Transthyretin cardiac amyloidosis (ATTR-CA) has a deep impact on the quality of life (QoL), yet no specific patient-reported outcome measures (PROMs) for ATTR-CA exist. The ITALY study involved 5 Italian referral centres (Pisa, Pavia, Ferrara, Florence, Messina) enrolling consecutive outpatients with ATTR-CA. Two 30-item questionnaires were created for wild-type (wt) and variant (v) ATTR-CA. Scores ranged from 100 (best condition) to 0 (worst condition). Out of 140 patients enrolled (77% with ATTRwt-CA), 115 repeated the re-evaluation at 6 months. At baseline, only 30% of patients needed help to fill out the questionnaires. Among baseline variables, all KCCQ and SF-36 domains were univariate predictors of ITALY scores in ATTRwt-CA patients, with the KCCQ Symptom Summary score (beta coefficient 0.759), Social Limitations (0.781), and Overall summary score (0.786) being the strongest predictors. The SF-36 Emotional well-being score (0.608), the KCCQ Overall summary score (0.656), and the SF-36 Energy/fatigue score (0.669) were the strongest univariate predictors of ITALY scores in ATTRv-CA. Similar results were found at 6 months. The ITALY questionnaires are the first specific PROMs for ATTRwt- and ATTRv-CA. Questionnaire completion is feasible. ITALY scores display close relationships with non-ATTR-specific measures of QoL. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Patient-reported outcome measures for transthyretin cardiac amyloidosis: the ITALY study

Author

Aimo, Alberto, primary, Teresi, Lucio, additional, Castiglione, Vincenzo, additional, Picerni, Anna Lisa, additional, Niccolai, Martina, additional, Severino, Silvia, additional, Agazio, Assunta, additional, Carnevale Baraglia, Anna, additional, Obici, Laura, additional, Palladini, Giovanni, additional, Ponti, Lucia, additional, Argirò, Alessia, additional, Cappelli, Francesco, additional, Perfetto, Federico, additional, Serenelli, Matteo, additional, Trimarchi, Giancarlo, additional, Licordari, Roberto, additional, Di Bella, Gianluca, additional, Chubuchna, Olena, additional, Quattrone, Filippo, additional, Nuti, Sabina, additional, De Rosis, Sabina, additional, Passino, Claudio, additional, Rapezzi, Claudio, additional, Merlini, Giampaolo, additional, Emdin, Michele, additional, and Vergaro, Giuseppe, additional

Published
2023
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36. Sex differences in transthyretin cardiac amyloidosis

Author

Aimo, Alberto, primary, Panichella, Giorgia, additional, Garofalo, Manuel, additional, Gasparini, Simone, additional, Arzilli, Chiara, additional, Castiglione, Vincenzo, additional, Vergaro, Giuseppe, additional, Emdin, Michele, additional, and Maffei, Silvia, additional

Published
2023
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37. Prognostic value of soluble ST2 in AL and TTR cardiac amyloidosis: a multicenter study

Author

Nicol, Martin, primary, Vergaro, Giuseppe, additional, Damy, Thibaud, additional, Kharoubi, Mounira, additional, Baudet, Mathilde, additional, Canuti, Elena Sofia, additional, Aimo, Alberto, additional, Castiglione, Vincenzo, additional, Emdin, Michele, additional, Royer, Bruno, additional, Harel, Stephanie, additional, Cohen-Solal, Alain, additional, Arnulf, Bertrand, additional, and Logeart, Damien, additional

Published
2023
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38. Different Continuous Training Intensities Improve Echocardiographic Parameters, Quality of Life, and Functional Capacity in Heart Failure Patients with Reduced Ejection Fraction

Author

Abdeen, Heba A, primary, Helmy, Zeinab M, additional, Elnaggar, Moustafa I, additional, Aldhahi, Monira I, additional, Taha, Mona, additional, Marques-Sule, Elena, additional, Amin, Doaa I, additional, Ibrahim, Bassem S, additional, Abdel Aziz, Ahmed, additional, Castiglione, Vincenzo, additional, and Atef, Hady, additional

Published
2023
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39. Diagnostic Tools: The Easier, the Better

Author

Poletti, Roberta, Aimo, Alberto, Castiglione, Vincenzo, Di Gangi, Alessandro, Iudice, Giovanni, Micalizzi, Mauro, Passino, Claudio, Emdin, Michele, Emdin, Michele, editor, Giannoni, Alberto, editor, and Passino, Claudio, editor

Published
2017
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40. Haemodynamic forces predicting remodelling and outcome in patients with heart failure treated with sacubitril/valsartan

Author

Fabiani, Iacopo, primary, Pugliese, Nicola Riccardo, additional, Pedrizzetti, Gianni, additional, Tonti, Giovanni, additional, Castiglione, Vincenzo, additional, Chubuchny, Vladislav, additional, Taddei, Claudia, additional, Gimelli, Alessia, additional, Del Punta, Lavinia, additional, Balletti, Alessio, additional, Del Franco, Annamaria, additional, Masi, Stefano, additional, Lombardi, Carlo Mario, additional, Cameli, Matteo, additional, Emdin, Michele, additional, and Giannoni, Alberto, additional

Published
2023
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41. Cardiovascular toxicity from therapies for light chain amyloidosis

Author

Morfino, Paolo, primary, Aimo, Alberto, additional, Castiglione, Vincenzo, additional, Chianca, Michela, additional, Vergaro, Giuseppe, additional, Cipolla, Carlo Maria, additional, Fedele, Antonella, additional, Emdin, Michele, additional, Fabiani, Iacopo, additional, and Cardinale, Daniela, additional

Published
2023
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42. Right ventricular to pulmonary artery coupling and outcome in patients with cardiac amyloidosis

Author

Tomasoni, Daniela, primary, Adamo, Marianna, additional, Porcari, Aldostefano, additional, Aimo, Alberto, additional, Bonfioli, Giovanni Battista, additional, Castiglione, Vincenzo, additional, Franzini, Maria, additional, Inciardi, Riccardo Maria, additional, Khalil, Anas, additional, Lombardi, Carlo Mario, additional, Lupi, Laura, additional, Nardi, Matilde, additional, Oriecuia, Chiara, additional, Pagnesi, Matteo, additional, Panichella, Giorgia, additional, Rossi, Maddalena, additional, Saccani, Nicola, additional, Specchia, Claudia, additional, Vergaro, Giuseppe, additional, Merlo, Marco, additional, Sinagra, Gianfranco, additional, Emdin, Michele, additional, and Metra, Marco, additional

Published
2023
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45. Role of Imaging in Cardiomyopathies

Author

Castiglione, Vincenzo, primary, Aimo, Alberto, additional, Todiere, Giancarlo, additional, Barison, Andrea, additional, Fabiani, Iacopo, additional, Panichella, Giorgia, additional, Genovesi, Dario, additional, Bonino, Lucrezia, additional, Clemente, Alberto, additional, Cademartiri, Filippo, additional, Giannoni, Alberto, additional, Passino, Claudio, additional, Emdin, Michele, additional, and Vergaro, Giuseppe, additional

Published
2023
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47. Left ventricular wall thickness and severity of cardiac disease in women and men with transthyretin amyloidosis

Author

Aimo, Alberto, Tomasoni, Daniela, Porcari, Aldostefano, Vergaro, Giuseppe, Castiglione, Vincenzo, Passino, Claudio, Adamo, Marianna, Bellicini, Maria Giulia, Lombardi, Carlo Mario, Nardi, Matilde, Palamara, Gloria, Varrà, Guerino Giuseppe, Saro, Riccardo, Allegro, Valentina, Merlo, Marco, Sinagra, Gianfranco, Metra, Marco, Emdin, Michele, Rapezzi, Claudio, Aimo, Alberto, Tomasoni, Daniela, Porcari, Aldostefano, Vergaro, Giuseppe, Castiglione, Vincenzo, Passino, Claudio, Adamo, Marianna, Bellicini, Maria Giulia, Lombardi, Carlo Mario, Nardi, Matilde, Palamara, Gloria, Varrà, Guerino Giuseppe, Saro, Riccardo, Allegro, Valentina, Merlo, Marco, Sinagra, Gianfranco, Metra, Marco, Emdin, Michele, and Rapezzi, Claudio

Subjects
Wall thickness, Diagnosis, Amyloidosi, Gender difference, Cut-off, Gender differences, Amyloidosis, Transthyretin, Cardiology and Cardiovascular Medicine, Diagnosi
Abstract

Aims: Cardiac amyloidosis (CA) is due to a deposition of amyloid fibrils in the heart causing an increase in wall thickness. A left ventricular (LV) wall thickness ≥12 mm plus at least one red flag should raise the suspicion of CA. As normal values of LV wall thickness are lower in women, the adoption or the same cut-off values for men and women could lead to underdiagnosis or delayed diagnosis in women. We investigated the relationship between LV wall thickness and the severity of cardiac involvement in women and men with transthyretin (ATTR) CA. Methods and results: We evaluated 330 consecutive patients diagnosed with ATTR-CA at three centres (Pisa, n = 232; Brescia, n = 69; Trieste, n = 29). Interventricular septum (IVS) and posterior wall (PW) thickness values were lower in women (n = 53, 16%) than men, but most differences were abolished when indexing by body surface area (BSA), height, or height, suggesting similar disease severity when accounting for the smaller body size of women. PW thickness indexed for height was even higher in women. We also searched for correlations between IVS and PW thickness and other indicators of the severity of cardiac disease. IVS values indexed by height displayed tighter associations with N-terminal pro-B-type natriuretic peptide values than non-indexed IVS values. Similarly, indexed values displayed closer relationships with relative wall thickness, E/e' ratio, and tricuspid annular plane systolic excursion. Conclusions: Indexed LV wall thickness values, particularly by height, reflect more accurately the severity of cardiac involvement than non-indexed values.

Published
2023

48. Head‐to‐head comparison between recommendations by the <scp>ESC</scp> and <scp>ACC</scp> / <scp>AHA</scp> / <scp>HFSA</scp> heart failure guidelines

Author

Bayés-Genís, Antoni, Aimo, Alberto, Metra, Marco, Anker, Stefan, Seferovic, Petar, Rapezzi, Claudio, Castiglione, Vincenzo, Núñez, Julio, Emdin, Michele, Rosano, Giuseppe, and Coats, Andrew J S

Subjects
Heart Failure, Cardiology, Stroke Volume, Comparison, American Heart Association, Clinical practice, Guidelines, Recommendations, United States, Medical, Humans, Societies, Cardiology and Cardiovascular Medicine, Heart failure, Societies, Medical
Abstract

Recommendations represent the core messages of guidelines, and are particularly important when the body of scientific evidence is rapidly growing, as in the case of heart failure (HF). The main messages from two latest major HF guidelines, endorsed by the European Society of Cardiology (ESC) and the American College of Cardiology/American Heart Association/Heart Failure Society of America (ACC/AHA/HFSA), are partially overlapping, starting from the four pillars of treatment for HF with reduced ejection fraction. Some notable differences exist, in part related to the timing of recent publications (most notably, the Universal Definition of HF paper and the EMPEROR-Preserved trial), and in part reflecting differing views of the natural history of HF (with a clear differentiation between stages A and B HF in the ACC/AHA/HFSA guidelines). Different approaches are proposed to specific issues such as risk stratification and implantable cardioverter defibrillator use for primary prevention in HFrEF patients with non-ischaemic aetiology. The ACC/AHA/HFSA guidelines put a greater emphasis on some issues that are particularly relevant to the US setting, such as the cost-effectiveness of therapies and the impact of health disparities on HF care. A comparison between guideline recommendations may give readers a deeper understanding of the ESC and ACC/AHA/HFSA guidelines, and help them apply sensible approaches to their own practice, wherever that may be in the world. A comparison may possibly also help further harmonization of recommendations between future guidelines, by identifying why some areas have led to conflicting recommendation, even when ostensibly reviewing the same published evidence.

Published
2022

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