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3. Populations particulières : impact de l’état général et des principales comorbidités et de leurs traitements sur la prise en charge thérapeutique locale des patients présentant un Cancer Bronchique Non à Petites Cellules

Author

Gounant, V., Ezzedine, R., Duchemann, B., Pierret, T., Brosseau, S., Castier, Y., Zalcman, G., and Mordant, P.

Abstract

De nombreux facteurs, liés au cancer ou aux comorbidités, peuvent influencer le Performance Status (PS). Le PS est un facteur pronostique indépendant majeur des CBNPC malgré la très grande hétérogénéité des patients présentant un PS altéré. Les cancers du poumon surviennent le plus souvent à un âge avancé et sont pour la plupart liés au tabagisme, âge et tabagisme pouvant être responsables de défaillances d’organes. Les comorbidités et le PS doivent être pris en compte pour choisir le traitement adapté. L’objectif de cette revue est d’évaluer l’impact respectif de l’état général et des comorbidités cardiaques, rénales, hépatiques ou l’existence d’une pneumopathie interstitielle diffuse sur la prise en charge et les choix thérapeutiques des CBNPC localisés.

Published
2024
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7. Impact de la période périopératoire sur le pronostic de la transplantation pulmonaire chez les patients ayant des dilatations des bronches non liées à la mucoviscidose

Author

Decaux, S., primary, Roux, A., additional, Mal, H., additional, Glorion, M., additional, Miranda (de), S., additional, Sage, E., additional, Bunel, V., additional, Castier, Y., additional, Roussel, A., additional, Montravers, P., additional, Mordant, P., additional, and Messika, J., additional

Published
2024
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10. Effet protecteur du FGF21 endogène et exogène dans la fibrose pulmonaire

Author

Ghanem, M., primary, Archer, G., additional, Justet, A., additional, Hachem, M., additional, Boghanim, T., additional, Vadel, A., additional, Poté, N., additional, Cazes, A., additional, Mordant, P., additional, Castier, Y., additional, Mal, H., additional, Jaillet, M., additional, Mailleux, A., additional, and Crestani, B., additional

Published
2023
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11. Effet protecteur du FGF21 dans la fibrose pulmonaire

Author

Ghanem, M., primary, Archer, G., additional, Justet, A., additional, Hachem, M., additional, Boghanim, T., additional, Vadel, A., additional, Poté, N., additional, Cazes, A., additional, Mordant, P., additional, Castier., Y., additional, Mal, H., additional, Jaillet, M., additional, Mailleux, A., additional, and Crestani, B., additional

Published
2023
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12. Editor's Choice – ECAR (Endovasculaire ou Chirurgie dans les Anévrysmes aorto-iliaques Rompus): A French Randomized Controlled Trial of Endovascular Versus Open Surgical Repair of Ruptured Aorto-iliac Aneurysms

Author

Desgranges, P., Kobeiter, H., Katsahian, S., Bouffi, M., Gouny, P., Favre, J.-P., Alsac, J.M., Sobocinski, J., Julia, P., Alimi, Y., Steinmetz, E., Haulon, S., Alric, P., Canaud, L., Castier, Y., Jean-Baptiste, E., Hassen-Khodja, R., Lermusiaux, P., Feugier, P., Destrieux-Garnier, L., Charles-Nelson, A., Marzelle, J., Majewski, M., Bourmaud, A., and Becquemin, J.-P.

Published
2015
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15. Individual-patient meta-analysis of three randomized trials comparing endovascular versus open repair for ruptured abdominal aortic aneurysm

Author

Sweeting, M. J., Balm, R., Desgranges, P., Ulug, P., Powell, J. T., Koelemay, M. J. W., Idu, M. M., Kox, C., Legemate, D. A., Huisman, L. C., Willems, M. C. M., Reekers, J. A., van Delden, O. M., van Lienden, K. P., Hoornweg, L. L., Reimerink, J. J., van Beek, S. C., Vahl, A. C., Leijdekkers, V. J., Bosma, J., Montauban van Swijndregt, A. D., de Vries, C., van der Hulst, V. P. M., Peringa, J., Blomjous, J. G. A. M., Visser, M. J. T., van der Heijden, F. H. W. M., Wisselink, W., Hoksbergen, A. W. J., Blankensteijn, J. D., Visser, M. T. J., Coveliers, H. M. E., Nederhoed, J. H., van den Berg, F. G., van der Meijs, B. B., van den Oever, M. L. P., Lely, R. J., Meijerink, M. R., Voorwinde, A., Ultee, J. M., van Nieuwenhuizen, R. C., Dwars, B. J., Nagy, T. O. M., Tolenaar, P., Wiersema, A. M., Lawson, J. A., van Aken, P. J., Stigter, A. A., van den Broek, T. A. A., Vos, G. A., Mulder, W., Strating, R. P., Nio, D., Akkersdijk, G. J. M., van der Elst, A., van Exter, P., Becquemin, J.-P., Allaire, E., Cochennec, F., Marzelle, J., Louis, N., Schneider, J., Majewski, M., Castier, Y., Leseche, G., Francis, F., Steinmetz, E., Berne, J.-P., Favier, C., Haulon, S., Koussa, M., Azzaoui, R., Piervito, D., Alimi, Y., Boufi, M., Hartung, O., Cerquetta, P., Amabile, P., Piquet, P., Penard, J., Demasi, M., Alric, P., Canaud, L., Berthet, J.-P., Julia, P., Fabiani, J.-N., Alsac, J. M., Gouny, P., Badra, A., Braesco, J., Favre, J.-P., Albertini, J.-N., Martinez, R., Hassen-Khodja, R., Batt, M., Jean, E., Sosa, M., Declemy, S., Destrieux-Garnier, L., Lermusiaux, P., Feugier, P., Ashleigh, R., Gomes, M., Greenhalgh, R. M., Grieve, R., Hinchliffe, R., Sweeting, M., Thompson, M. M., Thompson, S. G., Cheshire, N. J., Boyle, J. R., Serracino-Inglott, F., Smyth, J. V., Hinchliffe, R. J., Bell, R., Wilson, N., Bown, M., Dennis, M., Davis, M., Howell, S., Wyatt, M. G., Valenti, D., Bachoo, P., Walker, P., MacSweeney, S., Davies, J. N., Rittoo, D., Parvin, S. D., Yusuf, W., Nice, C., Chetter, I., Howard, A., Chong, P., Bhat, R., McLain, D., Gordon, A., Lane, I., Hobbs, S., Pillay, W., Rowlands, T., El-Tahir, A., Asquith, J., Cavanagh, S., Dubois, L., and Forbes, T. L.

Published
2015
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17. Progression rapide de la fibrose du poumon natif associée à une infection virale sévère après transplantation monopulmonaire pour fibrose

Author

Goletto, T., primary, Decaux, S., additional, Bunel, V., additional, Weisenburger, G., additional, Messika, J., additional, Najem, S., additional, Medraoui, C., additional, Godet, C., additional, Mordant, P., additional, Castier, Y., additional, Bouadma, L., additional, Borie, R., additional, and Mal, H., additional

Published
2021
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20. Acute Kidney Injury After Lung Transplantation: Perioperative Risk Factors and Outcome

Author

Atchade, E., primary, Barour, S., additional, Tran-Dinh, A., additional, Jean-Baptiste, S., additional, Tanaka, S., additional, Tashk, P., additional, Snauwaert, A., additional, Lortat-Jacob, B., additional, Mourin, G., additional, Mordant, P., additional, Castier, Y., additional, Mal, H., additional, De Tymowski, C., additional, and Montravers, P., additional

Published
2020
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21. Performance diagnostique de la biopsie pulmonaire chirurgicale dans la prise en charge des pneumopathies interstitielles diffuses

Author

Le Guen, P., primary, Debray, M.P., additional, Mordant, P., additional, Guyard, A., additional, Iquille, J., additional, Taille, C., additional, Borie, R., additional, Dombret, M.C., additional, Ghanem, M., additional, Frija-Masson, J., additional, Bancal, C., additional, Khalil, A., additional, Cazes, A., additional, Castier, Y., additional, and Crestani, B., additional

Published
2020
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23. Fungal Isolation in Respiratory Tract After Lung Transplantation: Epidemiology, Clinical Consequences, and Associated Factors

Author

Atchade, E., primary, Desmard, M., additional, Kantor, E., additional, Genève, C., additional, Tebano, G., additional, De Tymowski, C., additional, Tran-dinh, A., additional, Zappella, N., additional, Houzé, S., additional, Mal, H., additional, Castier, Y., additional, Tanaka, S., additional, and Montravers, P., additional

Published
2020
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28. Donor Club Cell Secretory Protein G38A Polymorphism Is Associated With a Decreased Risk of Primary Graft Dysfunction in the French Cohort in Lung Transplantation

Author

Hin, A., Kannengiesser, C., Roussel, A., Renaud-Picard, B., Roux, A., Reynaud-Gaubert, M., Claustre, J., Tissot, A., Guillemain, R., Mornex, Jean-François, Mussot, S., Dromer, C., Dahan, M., Brugiere, O., Mercier, O., Borie, R., Pretolani, M., Castier, Y., Mordant, P., Consortium, COLT, Infections Virales et Pathologie Comparée - UMR 754 (IVPC), Institut National de la Recherche Agronomique (INRA)-École pratique des hautes études (EPHE)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Institut National de la Recherche Agronomique (INRA)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Claude Bernard Lyon 1 (UCBL), and Vaincre la Mucoviscidose

Subjects
Male, Adult, medicine.medical_specialty, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Primary Graft Dysfunction, 030230 surgery, Gastroenterology, Polymorphism, Single Nucleotide, Tissue Donors, 03 medical and health sciences, 0302 clinical medicine, Interquartile range, Risk Factors, Internal medicine, Medicine, Lung transplantation, Uteroglobin, Humans, Prospective Studies, Prospective cohort study, Retrospective Studies, Primary Graft Dysfunction/*genetics, Transplantation, Lung, Uteroglobin/*genetics, business.industry, Retrospective cohort study, Odds ratio, Single Nucleotide, respiratory system, Middle Aged, medicine.anatomical_structure, Treatment Outcome, 030228 respiratory system, Reperfusion Injury, Cohort, Multivariate Analysis, Female, Gene-Environment Interaction, France, business, Polymorphism, Lung Transplantation, Lung Transplantation/*methods
Abstract

BACKGROUND: Club Cell Secretory Protein (CCSP) G38A polymorphism has recently been involved in lung epithelial susceptibility to external injuries. Lung transplantation (LT) is currently limited by ischemia-reperfusion injury leading to primary graft dysfunction (PGD). We thus hypothesized that donor CCSP G38A polymorphism might impact the risk of PGD after LT. METHODS: We focused on LT included in the French multicentric Cohort in Lung Transplantation (COLT), performed between January 2009 and December 2014, and associated with preoperative blood samples from the donor and the recipient. Characteristics of the donors, recipients, procedures, early and late outcomes were prospectively recorded in COLT. The CCSP serum concentration and CCSP gene G38A polymorphism were retrospectively determined in a blind manner. Their association with grade 3 PGD was studied in univariate and multivariate analysis. RESULTS: The study group included 104 LT donors and recipients, 84 with grade 0 to 2 PGD and 20 with grade 3 PGD. Preoperative CCSP serum concentration was significantly higher in the donors (median, 22.54 ng/mL; interquartile range, 9.6-43.9) than in the recipients (median, 7.03 ng/mL; interquartile range, 0.89-19.2; P \\textless 0.001) but none impacted the risk of grade 3 PGD (P = 0.93 and P = 0.69, respectively). Donor CCSP G38A polymorphism was associated with a decreased risk of grade 3 PGD in univariate (AG + AA 3/21 = 14.2% vs GG 10/26 = 38.4%, P = 0.044) and multivariate analysis (odds ratio associated with AG + AA, 0.22; 95% confidence interval, 0.041-0.88; P = 0.045), but recipient CCSP G38A polymorphism was not. CONCLUSIONS: Donor CCSP G38A polymorphism is associated with a decreased risk of severe PGD after LT in the COLT study. These findings should be confirmed in the frame of a prospective study.

Published
2018

29. Diagnosis of Restrictive Allograft Syndrome (RAS) in Single-Lung Transplantation Using PFTs and CT-Scan Volumetry and Score

Author

Brugiere, O., primary, Philippot, Q., additional, Bun, R., additional, Couffignal, C., additional, Frijat, J., additional, Bunel, V., additional, Morer, L., additional, Mourin, G., additional, Jebrak, G., additional, Castier, Y., additional, Dauriat, G., additional, Mordant, P., additional, Mal, H., additional, and Debray, M., additional

Published
2019
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31. Control of the T follicular helper-germinal center B-cell axis by CD8+ regulatory T cells limits atherosclerosis and tertiary lymphoid organ development

Author

Clement, M, Guedj, K, Andreata, F, Morvan, M, Bey, L, Khallou-Laschet, J, Gaston, A, Delbosc, S, Alsac, J, Bruneval, P, Deschildre, C, Le Borgne, M, Castier, Y, Kim, H, Cantor, H, Michel, J, Caligiuri, G, Nicoletti, A, Clement M., Guedj K., Andreata F., Morvan M., Bey L., Khallou-Laschet J., Gaston A. -T., Delbosc S., Alsac J. -M., Bruneval P., Deschildre C., Le Borgne M., Castier Y., Kim H. -J., Cantor H., Michel J. -B., Caligiuri G., Nicoletti A., Clement, M, Guedj, K, Andreata, F, Morvan, M, Bey, L, Khallou-Laschet, J, Gaston, A, Delbosc, S, Alsac, J, Bruneval, P, Deschildre, C, Le Borgne, M, Castier, Y, Kim, H, Cantor, H, Michel, J, Caligiuri, G, Nicoletti, A, Clement M., Guedj K., Andreata F., Morvan M., Bey L., Khallou-Laschet J., Gaston A. -T., Delbosc S., Alsac J. -M., Bruneval P., Deschildre C., Le Borgne M., Castier Y., Kim H. -J., Cantor H., Michel J. -B., Caligiuri G., and Nicoletti A.

Abstract

BACKGROUND - : The atheromodulating activity of B cells during the development of atherosclerosis is well documented, but the mechanisms by which these cells are regulated have not been investigated. METHODS AND RESULTS - : Here, we analyzed the contribution of Qa-1-restricted CD8 regulatory T cells to the control of the T follicular helper-germinal center B-cell axis during atherogenesis. Genetic disruption of CD8 regulatory T cell function in atherosclerosis-prone apolipoprotein E knockout mice resulted in overactivation of this axis in secondary lymphoid organs, led to the increased development of tertiary lymphoid organs in the aorta, and enhanced disease development. In contrast, restoring control of the T follicular helper-germinal center B-cell axis by blocking the ICOS-ICOSL pathway reduced the development of atherosclerosis and the formation of tertiary lymphoid organs. Moreover, analyses of human atherosclerotic aneurysmal arteries by flow cytometry, gene expression analysis, and immunofluorescence confirmed the presence of T follicular helper cells within tertiary lymphoid organs. CONCLUSIONS - : This study is the first to demonstrate that the T follicular helper-germinal center B-cell axis is proatherogenic and that CD8 regulatory T cells control the germinal center reaction in both secondary and tertiary lymphoid organs. Therefore, disrupting this axis represents an innovative therapeutic approach.

Published
2015

34. Airway microbiota signals anabolic and catabolic remodeling in the transplanted lung

Author

Mouraux, Stéphane, primary, Bernasconi, Eric, additional, Pattaroni, Céline, additional, Koutsokera, Angela, additional, Aubert, John-David, additional, Claustre, Johanna, additional, Pison, Christophe, additional, Royer, Pierre-Joseph, additional, Magnan, Antoine, additional, Kessler, Romain, additional, Benden, Christian, additional, Soccal, Paola M., additional, Marsland, Benjamin J., additional, Nicod, Laurent P., additional, Jougon, J., additional, Velly, J.-F., additional, Rozé, H., additional, Blanchard, E., additional, Dromer, C., additional, Antoine, M., additional, Cappello, M., additional, Ruiz, M., additional, Sokolow, Y., additional, Vanden Eynden, F., additional, Van Nooten, G., additional, Barvais, L., additional, Berré, J., additional, Brimioulle, S., additional, De Backer, D., additional, Créteur, J., additional, Engelman, E., additional, Huybrechts, I., additional, Ickx, B., additional, Preiser, T.J.C., additional, Tuna, T., additional, Van Obberghe, L., additional, Vancutsem, N., additional, Vincent, J.-L., additional, De Vuyst, P., additional, Etienne, I., additional, Féry, F., additional, Jacobs, F., additional, Knoop, C., additional, Vachiéry, J.L., additional, Van den Borne, P., additional, Wellemans, I., additional, Amand, G., additional, Collignon, L., additional, Giroux, M., additional, Angelescu, D., additional, Chavanon, O., additional, Hacini, R., additional, Pirvu, A., additional, Porcu, P., additional, Albaladejo, P., additional, Allègre, C., additional, Bataillard, A., additional, Bedague, D., additional, Briot, E., additional, Casez-Brasseur, M., additional, Colas, D., additional, Dessertaine, G., additional, Durand, M., additional, Francony, G., additional, Hebrard, A., additional, Marino, M.R., additional, Oummahan, B., additional, Protar, D., additional, Rehm, D., additional, Robin, S., additional, Rossi-Blancher, M., additional, Augier, C., additional, Bedouch, P., additional, Boignard, A., additional, Bouvaist, H., additional, Briault, A., additional, Camara, B., additional, Claustre, J., additional, Chanoine, S., additional, Dubuc, M., additional, Quétant, S., additional, Maurizi, J., additional, Pavèse, P., additional, Pison, C., additional, Saint-Raymond, C., additional, Wion, N., additional, Chérion, C., additional, Grima, R., additional, Jegaden, O., additional, Maury, J.-M., additional, Tronc, F., additional, Flamens, C., additional, Paulus, S., additional, Mornex, J.-F., additional, Philit, F., additional, Senechal, A., additional, Glérant, J.-C., additional, Turquier, S., additional, Gamondes, D., additional, Chalabresse, L., additional, Thivolet-Bejui, F., additional, Barnel, C., additional, Dubois, C., additional, Tiberghien, A., additional, Le Pimpec-Barthes, F., additional, Bel, A., additional, Mordant, P., additional, Achouh, P., additional, Boussaud, V., additional, Guillemain, R., additional, Méléard, D., additional, Bricourt, M.O., additional, Cholley, B., additional, Pezella, V., additional, Brioude, G., additional, D'Journo, X.B., additional, Doddoli, C., additional, Thomas, P., additional, Trousse, D., additional, Dizier, S., additional, Leone, M., additional, Papazian, L., additional, Bregeon, F., additional, Basire, A., additional, Coltey, B., additional, Dufeu, N., additional, Dutau, H., additional, Garcia, S., additional, Gaubert, J.Y., additional, Gomez, C., additional, Laroumagne, S., additional, Nieves, A., additional, Picard, L.C., additional, Reynaud-Gaubert, M., additional, Secq, V., additional, Mouton, G., additional, Baron, O., additional, Lacoste, P., additional, Perigaud, C., additional, Roussel, J.C., additional, Danner, I., additional, Haloun, A., additional, Magnan, A., additional, Tissot, A., additional, Lepoivre, T., additional, Treilhaud, M., additional, Botturi-Cavaillès, K., additional, Brouard, S., additional, Danger, R., additional, Loy, J., additional, Morisset, M., additional, Pain, M., additional, Pares, S., additional, Reboulleau, D., additional, Royer, P.-J., additional, Fabre, D., additional, Fadel, E., additional, Mercier, O., additional, Mussot, S., additional, Stephan, F., additional, Viard, P., additional, Cerrina, J., additional, Dorfmuller, P., additional, Ghigna, S.M., additional, Hervén, Ph., additional, Le Roy Ladurie, F., additional, Le Pavec, J., additional, Thomas de Montpreville, V., additional, Lamrani, L., additional, Castier, Y., additional, Cerceau, P., additional, Augustin, P., additional, Jean-Baptiste, S., additional, Boudinet, S., additional, Montravers, P., additional, Brugière, O., additional, Dauriat, G., additional, Jébrak, G., additional, Mal, H., additional, Marceau, A., additional, Métivier, A.-C., additional, Thabut, G., additional, Lhuillier, E., additional, Dupin, C., additional, Bunel, V., additional, Falcoz, P., additional, Massard, G., additional, Santelmo, N., additional, Ajob, G., additional, Collange, O., additional, Helms, O., additional, Hentz, J., additional, Roche, A., additional, Bakouboula, B., additional, Degot, T., additional, Dory, A., additional, Hirschi, S., additional, Ohlmann-Caillard, S., additional, Kessler, L., additional, Kessler, R., additional, Schuller, A., additional, Bennedif, K., additional, Vargas, S., additional, Stauder, J., additional, Ali-Azouaou, S., additional, Bonnette, P., additional, Chapelier, A., additional, Puyo, P., additional, Sage, E., additional, Bresson, J., additional, Caille, V., additional, Cerf, C., additional, Devaquet, J., additional, Dumans-Nizard, V., additional, Felten, M.-L., additional, Fischler, M., additional, Si Larbi, A.-G., additional, Leguen, M., additional, Ley, L., additional, Liu, N., additional, Trebbia, G., additional, De Miranda, S., additional, Douvry, B., additional, Gonin, F., additional, Grenet, D., additional, Hamid, A.M., additional, Neveu, H., additional, Parquin, F., additional, Picard, C., additional, Roux, A., additional, Stern, M., additional, Bouillioud, F., additional, Cahen, P., additional, Colombat, M., additional, Dautricourt, C., additional, Delahousse, M., additional, D'Urso, B., additional, Gravisse, J., additional, Guth, A., additional, Hillaire, S., additional, Honderlick, P., additional, Lequintrec, M., additional, Longchampt, E., additional, Mellot, F., additional, Scherrer, A., additional, Temagoult, L., additional, Tricot, L., additional, Vasse, M., additional, Veyrie, C., additional, Zemoura, L., additional, Berjaud, J., additional, Brouchet, L., additional, Dahan, M., additional, Mathe, F.O., additional, Benahoua, H., additional, DaCosta, M., additional, Serres, I., additional, Merlet-Dupuy, V., additional, Grigoli, M., additional, Didier, A., additional, Murris, M., additional, Crognier, L., additional, Fourcade, O., additional, Krueger, T., additional, Ris, H.B., additional, Gonzalez, M., additional, Jolliet, Ph., additional, Marcucci, C., additional, Chollet, M., additional, Gronchi, F., additional, Courbon, C., additional, Berutto, C., additional, Manuel, O., additional, Koutsokera, A., additional, Aubert, J.-D., additional, Nicod, L.P., additional, Mouraux, S., additional, Bernasconi, E., additional, Pattaroni, C., additional, Marsland, B.J., additional, Soccal, P.M., additional, Rochat, T., additional, Lücker, L.M., additional, Hillinger, S., additional, Inci, I., additional, Weder, W., additional, Schuepbach, R., additional, Zalunardo, M., additional, Benden, C., additional, Schuurmans, M.M., additional, Gaspert, A., additional, Holzmann, D., additional, Müller, N., additional, Schmid, C., additional, Vrugt, B., additional, Fritz, A., additional, Maier, D., additional, Deplanche, K., additional, Koubi, D., additional, Ernst, F., additional, Paprotka, T., additional, Schmitt, M., additional, Wahl, B., additional, Boissel, J.-P., additional, Olivera-Botello, G., additional, Trocmé, C., additional, Toussaint, B., additional, Bourgoin-Voillard, S., additional, Sève, M., additional, Benmerad, M., additional, Siroux, V., additional, Slama, R., additional, Auffray, C., additional, Charron, D., additional, Lefaudeux, D., additional, and Pellet, J., additional

Published
2018
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35. Role of Complement-Binding Anti-HLA Antibodies Detection as Early Predictor of Chronic Lung Dysfunction After Lung Transplantation

Author

Brugière, O., primary, Roux, A., additional, Le Pavec, J., additional, Sroussi, D., additional, Parquin, F., additional, Pradère, P., additional, Dupin, C., additional, Bunel, V., additional, Mourin, G., additional, Jebrak, G., additional, Thabut, G., additional, Dauriat, G., additional, Castier, Y., additional, Mordant, P., additional, Lortat Jacob, B., additional, Jean-Baptiste, S., additional, Mal, H., additional, Suberbielle, C., additional, and Taupin, J., additional

Published
2017
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36. Membrane-anchored serine protease matriptase is a trigger of pulmonary fibrogenesis

Author

Bardou, O. (Olivier), Menou, A. (Awen), François, C. (Charlène), Duitman, J.W. (Jan Willem), Thusen, J.H. (Jan) von der, Borie, R. (Raphaël), Sales, K.U. (Katiuchia Uzzun), Mutze, K. (Kathrin), Castier, Y. (Yves), Sage, E. (Edouard), Liu, L. (Ligong), Bugge, T.H. (Thomas H.), Fairlie, D.P. (David P.), Königshoff, M. (Mélanie), Crestani, B. (Bruno), Borensztajn, K. (Keren), Bardou, O. (Olivier), Menou, A. (Awen), François, C. (Charlène), Duitman, J.W. (Jan Willem), Thusen, J.H. (Jan) von der, Borie, R. (Raphaël), Sales, K.U. (Katiuchia Uzzun), Mutze, K. (Kathrin), Castier, Y. (Yves), Sage, E. (Edouard), Liu, L. (Ligong), Bugge, T.H. (Thomas H.), Fairlie, D.P. (David P.), Königshoff, M. (Mélanie), Crestani, B. (Bruno), and Borensztajn, K. (Keren)

Abstract

Rationale: Idiopathic pulmonary fibrosis (IPF) is a devastating disease that remains refractory to current therapies. Objectives: To characterize the expression and activity of the membrane-anchored serine protease matriptase in IPF in humans and unravel its potential role in human and experimental pulmonary fibrogenesis. Methods: Matriptase expression was assessed in tissue specimens from patients with IPF versus control subjects using quantitative reverse transcriptase-polymerase chain reaction, immunohistochemistry, and Western blotting, while matriptase activity was monitored by fluorogenic substrate cleavage. Matriptaseinduced fibroproliferative responses and the receptor involved were characterized in human primary pulmonary fibroblasts by Western blot, viability, and migration assays. In the murine model of bleomycin-induced pulmonary fibrosis, the consequences of matriptase depletion, either by using the pharmacological inhibitor camostat mesilate (CM), or by genetic down-regulation using matriptase hypomorphic mice, were characterized by quantification of secreted collagen and immunostainings. Measurements and Main Results: Matriptase expression and activity were up-regulated in IPF and bleomycin-induced pulmonary fibrosis. In cultured human pulmonary fibroblasts, matriptase expression was significantly induced by transforming growth factor-b. Furthermore, matriptase elicited signaling via protease-activated receptor-2 (PAR-2), and promoted fibroblast activation, proliferation, and migration. In the experimental bleomycin model, matriptase depletion, by the pharmacological inhibitor CM or by genetic downregulation, diminished lung injury, collagen production, and transforming growth factor-b expression and signaling. Conclusions: These results implicate increased matriptase expression and activity in the pathogenesis of pulmonary fibrosis in human IPF and in an experimental mouse model. Overall, targeting matriptase, or treatment by CM, which is already in

Published
2016
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39. Blood CD9+B cell, a biomarker of bronchiolitis obliterans syndrome after lung transplantation

Author

Brosseau, Carole, Danger, Richard, Durand, Maxim, Durand, Eugénie, Foureau, Aurore, Lacoste, Philippe, Tissot, Adrien, Roux, Antoine, Reynaud‐Gaubert, Martine, Kessler, Romain, Mussot, Sacha, Dromer, Claire, Brugière, Olivier, Mornex, Jean François, Guillemain, Romain, Claustre, Johanna, Magnan, Antoine, Brouard, Sophie, Jougon, J., Velly, J.‐F., Rozé, H., Blanchard, E., Antoine, M., Cappello, M., Ruiz, M., Sokolow, Y., Vanden Eynden, F, Van Nooten, G., Barvais, L., Berré, J., Brimioulle, S., De Backer, D., Créteur, J., Engelman, E, Huybrechts, I., Ickx, B., Preiser, T.J.C., Tuna, T., Van Obberghe, L., Vancutsem, N., Vincent, J.‐L., De Vuyst, P., Etienne, I., Féry, F., Jacobs, F., Knoop, C., Vachiéry, J.L., Van den Borne, P., Wellemans, I., Amand, G., Collignon, L., Giroux, M., Angelescu, D., Chavanon, O., Hacini, R., Martin, C., Pirvu, A., Porcu, P., Albaladejo, P., Allègre, C., Bataillard, A., Bedague, D., Briot, E., Casez‐Brasseur, M., Colas, D., Dessertaine, G., Francony, G., Hebrard, A., Marino, M.R., Protar, D., Rehm, D., Robin, S, Rossi‐Blancher, M., Augier, C., Bedouch, P., Boignard, A., Bouvaist, H., Briault, A., Camara, B., Chanoine, S., Dubuc, M., Quétant, S., Maurizi, J., Pavèse, P., Pison, C., Saint‐Raymond, C., Wion, N., Chérion, C., Grima, R., Jegaden, O., Maury, J.‐M., Tronc, F., Flamens, C., Paulus, S., Philit, F., Senechal, A., Glérant, J.‐C., Turquier, S., Gamondes, D., Chalabresse, L., Thivolet‐Bejui, F., Barnel, C., Dubois, C., Tiberghien, A., Pimpec‐Barthes, F., Bel, A., Mordant, P., Achouh, P., Boussaud, V., Méléard, D., Bricourt, M.O., Cholley, B., Pezella, V., Brioude, G., D'Journo, X.B., Doddoli, C., Thomas, P., Trousse, D., Dizier, S., Leone, M., Papazian, L., Bregeon, F., Coltey, B., Dufeu, N., Dutau, H., Garcia, S., Gaubert, J.Y., Gomez, C., Laroumagne, S., Mouton, G., Nieves, A., Picard, Ch., Rolain, J.M., Sampol, E., Secq, V., Perigaud, C., Roussel, J.C., Senage, T., Mugniot, A., Danner, I., Haloun, A., Abbes, S., Bry, C., Blanc, F.X., Lepoivre, T., Botturi‐Cavaillès, K., Loy, J., Bernard, M., Godard, E., Royer, P.‐J., Henrio, K., Dartevelle, Ph., Fabre, D., Fadel, E., Mercier, O., Stephan, F., Viard, P., Cerrina, J., Dorfmuller, P., Feuillet, S., Ghigna, M., Hervén, Ph., Le Roy Ladurie, F., Le Pavec, J., Thomas de Montpreville, V., Lamrani, L., Castier, Y., Mordant, P., Cerceau, P., Augustin, P., Jean‐Baptiste, S., Boudinet, S., Montravers, P., Dauriat, G., Jébrak, G., Mal, H., Marceau, A., Métivier, A.‐C., Thabut, G., Lhuillier, E., Dupin, C., Bunel, V., Falcoz, P., Massard, G., Santelmo, N., Ajob, G., Collange, O., Helms, O., Hentz, J., Roche, A., Bakouboula, B., Degot, T., Dory, A., Hirschi, S., Ohlmann‐Caillard, S., Kessler, L., Schuller, A., Bennedif, K., Vargas, S., Bonnette, P., Chapelier, A., Puyo, P., Sage, E., Bresson, J., Caille, V., Cerf, C., Devaquet, J., Dumans‐Nizard, V., Felten, M.L., Fischler, M., Si Larbi, A.G., Leguen, M., Ley, L., Liu, N., Trebbia, G., De Miranda, S., Douvry, B., Gonin, F., Grenet, D., Hamid, A.M., Neveu, H., Parquin, F., Picard, C., Stern, M., Bouillioud, F., Cahen, P., Colombat, M., Dautricourt, C., Delahousse, M., D'Urso, B., Gravisse, J., Guth, A., Hillaire, S., Honderlick, P., Lequintrec, M., Longchampt, E., Mellot, F., Scherrer, A., Temagoult, L., Tricot, L., Vasse, M., Veyrie, C., Zemoura, L., Dahan, M., Murris, M., Benahoua, H., Berjaud, J., Le Borgne Krams, A., Crognier, L., Brouchet, L., Mathe, O., Didier, A., Krueger, T., Ris, H.B., Gonzalez, M., Aubert, J.‐D., Nicod, L.P., Marsland, B.J., Berutto, T.C., Rochat, T., Soccal, P., Jolliet, Ph., Koutsokera, A., Marcucci, C., Manuel, O., Bernasconi, E., Chollet, M., Gronchi, F., Courbon, C., Hillinger, S., Inci, I., Kestenholz, P., Weder, W., Schuepbach, R., Zalunardo, M., Benden, C., Buergi, U., Huber, L.C., Isenring, B., Schuurmans, M.M., Gaspert, A., Holzmann, D., Müller, N., Schmid, C., Vrugt, B., Rechsteiner, T., Fritz, A., Maier, D., Deplanche, K., Koubi, D., Ernst, F., Paprotka, T., Schmitt, M., Wahl, B., Boissel, J.‐P., Olivera‐Botello, G., Trocmé, C., Toussaint, B., Bourgoin‐Voillard, S., Séve, M., Benmerad, M., Siroux, V., Slama, R., Auffray, C., Charron, D., Lefaudeux, D., and Pellet, J.

Abstract

Bronchiolitis obliterans syndrome is the main limitation for long‐term survival after lung transplantation. Some specific B cell populations are associated with long‐term graft acceptance. We aimed to monitor the B cell profile during early development of bronchiolitis obliterans syndrome after lung transplantation. The B cell longitudinal profile was analyzed in peripheral blood mononuclear cells from patients with bronchiolitis obliterans syndrome and patients who remained stable over 3 years of follow‐up. CD24hiCD38hitransitional B cells were increased in stable patients only, and reached a peak 24 months after transplantation, whereas they remained unchanged in patients who developed a bronchiolitis obliterans syndrome. These CD24hiCD38hitransitional B cells specifically secrete IL‐10 and express CD9. Thus, patients with a total CD9+B cell frequency below 6.6% displayed significantly higher incidence of bronchiolitis obliterans syndrome (AUC = 0.836, PPV = 0.75, NPV = 1). These data are the first to associate IL‐10‐secreting CD24hiCD38hitransitional B cells expressing CD9 with better allograft outcome in lung transplant recipients. CD9‐expressing B cells appear as a contributor to a favorable environment essential for the maintenance of long‐term stable graft function and as a new predictive biomarker of bronchiolitis obliterans syndrome–free survival. In lung transplant patients with bronchiolitis obliterans syndrome and patients who remained stable over 3 years of follow‐up, IL‐10–secreting CD24hiCD38hi transitional B cells expressing CD9 are associated with better allograft outcome, suggesting CD9‐expressing B cells as a new predictive biomarker of bronchiolitis obliterans syndrome–free survival.

Published
2019
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41. ECAR (Endovasculaire ou Chirurgie dans les Anévrysmes aorto-iliaques Rompus): A French Randomized Controlled Trial of Endovascular Versus Open Surgical Repair of Ruptured Aorto-iliac Aneurysms

Author

Desgranges, P., primary, Kobeiter, H., additional, Katsahian, S., additional, Bouffi, M., additional, Gouny, P., additional, Favre, J.-P., additional, Alsac, J.M., additional, Sobocinski, J., additional, Julia, P., additional, Alimi, Y., additional, Steinmetz, E., additional, Haulon, S., additional, Alric, P., additional, Canaud, L., additional, Castier, Y., additional, Jean-Baptiste, E., additional, Hassen-Khodja, R., additional, Lermusiaux, P., additional, Feugier, P., additional, Destrieux-Garnier, L., additional, Charles-Nelson, A., additional, Marzelle, J., additional, Majewski, M., additional, Bourmaud, A., additional, and Becquemin, J.-P., additional

Published
2015
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44. Endothelin receptorantagonism prevents vaso-occlusion induced hemodynamic changes, reduces renal and lung damage and abrogates hypoxia-induced mortality in experimental sickle cell disease

Author

Sabaa, N, DE FRANCESCHI, Lucia, Bonnin, P, Castier, Y, Malpeli, Giorgio, Debbabi, H, Galaup, A, Maier Redelsperger, M, Vandermeersch, S, Scarpa, Aldo, Janin, A, Levy, B, Girot, R, Beuzard, Y, Leboeuf, C, Henri, A, Germain, S, Dussaule, Jc, and Tharaux, Pl

Subjects
endothelin receptor antagonist, hypoxia, sickle cell disease, mouse model
Published
2008

45. Survie à long terme et résection intestinale après ischémie mésentérique aiguë : étude observationnelle rétrospective de cohorte évaluant les facteurs pronostiques sur 164 survivants

Author

Nuzzo, A., primary, Bouhnik, Y., additional, Ronot, M., additional, Stefanescu, C., additional, Boudaoud, L., additional, Plessier, A., additional, Cazals-Hatem, D., additional, De Raucourt, E., additional, Elkrief, L., additional, Pasquet, B., additional, Castier, Y., additional, Paugam-Burtz, C., additional, Panis, Y., additional, Joly, F., additional, and Corcos, O., additional

Published
2014
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48. Chylothorax

Author

Mordant, P., primary, Castier, Y., additional, Le Pimpec-Barthes, F., additional, and Riquet, M., additional

Published
2012
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49. 712 Extracorporeal Membrane Oxygenation as a Bridge to Lung Transplant: First Results of the French Experience, 2007-2011

Author

Mordant, P., primary, Lafarge, M., additional, Castier, Y., additional, Brouchet, L., additional, Falcoz, P.E., additional, Haloun, A., additional, Le Pimpec-Barthes, F., additional, Lesèche, G., additional, Maury, J.-M., additional, Reynaud-Gaubert, M., additional, Saint-Raymond, C., additional, Stern, M., additional, and Mal, H., additional

Published
2012
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50. Résultats de l’assistance par ECMO dans l’attente d’une transplantation pulmonaire en super urgence en France

Author

Lafarge, M., primary, Mordant, P., additional, Castier, Y., additional, Brouchet, L., additional, Falcoz, P.-E., additional, Haloun, A., additional, Le Pimpec-Barthes, F., additional, Leseche, G., additional, Maury, J.-M., additional, Reynaud-Gaubert, M., additional, Saint-Raymond, C., additional, Stern, M., additional, and Mal, H., additional

Published
2012
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