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5. Topic: AS07-Singular Entities/Subtypes/AS07a-ARCH, CCUS, ICUS: CLINICAL AND CARDIOVASCULAR RISK ASSESSMENT OF SUBJECTS WITH JAK2-V617F CLONAL HEMATOPOIESIS

Author

Garrido, S., primary, López-Cadenas, F., additional, García-Ávila, S., additional, Tazón-Vega, B., additional, Blanco, A., additional, Palomo, L., additional, Piris-Villaespesa, M., additional, García-Gutiérrez, V., additional, De Vilar, M., additional, Sola, M., additional, Yordi, A. Molero, additional, González, A. Pérez, additional, Restrepo, J., additional, Fox, L., additional, Saumell, S., additional, Novoa, S., additional, Gallur, L., additional, Salamero, O., additional, Oristrell, G., additional, Castellví, J., additional, Valcárcel, D., additional, and Montoro, M.J., additional

Published
2023
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9. P105 - Topic: AS07-Singular Entities/Subtypes/AS07a-ARCH, CCUS, ICUS: CLINICAL AND CARDIOVASCULAR RISK ASSESSMENT OF SUBJECTS WITH JAK2-V617F CLONAL HEMATOPOIESIS

Author

Garrido, S., López-Cadenas, F., García-Ávila, S., Tazón-Vega, B., Blanco, A., Palomo, L., Piris-Villaespesa, M., García-Gutiérrez, V., De Vilar, M., Sola, M., Yordi, A. Molero, González, A. Pérez, Restrepo, J., Fox, L., Saumell, S., Novoa, S., Gallur, L., Salamero, O., Oristrell, G., Castellví, J., Valcárcel, D., and Montoro, M.J.

Published
2023
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13. Involvement in Catalonia of the Anaesthesiology and Resuscitation Services in the SARS-CoV-2 pandemic. A real, cost-effective solution to an unprecedented health crisis

Author

Villalonga Vadell, R.M., Sala Blanch, X., Roigé Solé, J., Garcia Eroles, X., Morros Viñoles, C., Valero Castell, R., Bausili Ribera, M., Pedregosa Sanz, A., Sergi Angeles Fite, G., Abreu Paradell, S., Adalia Bartolomé, R., Álvarez Pérez, A., Amigó Bonet, N., Asbert Sagasti, R., Barbal Badia, F., Carramiñana Dominguez, A., Castellnou Ferré, J., Bernia Gil, J.A., Carol Boeris, F., Colomina Soler, M.J., Chamero Pastilla, A., del Moral García, M.V., del Pozo, D., Escolano Villén, F., Esquius Jofre, P., Ferrando Ortolá, C., García Marqueta, C., Hernández Aguado, C., Hernando Pastor, D., Isach Comallonga, N., Isern Domingo, X., Cesar Jaramillo Carrión, L., Koo García, M., Lacambra Basil, M., Lázaro Alcay, J.J., Mailan Bello, J., Manrique Muñoz, S., Martínez Palli, G., Martínez Jérez, L., Masdeu Castellví, J., Mercadal Mercadal, J., Montero Matamala, A., Morales Torres, O., Moret Ferron, M.L., Moret Ruiz, E., Muñoz Falcón, L., de Nadal Clanchet, M., Miquel Ortells Nebot, P., Prat Vallribera, A., Remartinez Fernandez, F., Roca Campos, P., Roldan Osuna, J., Sabaté Pes, A., Sala Francino, P., Saludes Serra, J., Samsó Sabe, E., Sarmiento Meneses, E., Soto Ejarque, J.M., Tomas Torrelles, A., Tomás Esteban, A., and Yuste Graupera, M.

Published
2021
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14. Implicación en Cataluña de los Servicios de Anestesiología y Reanimación en la pandemia por SARS-CoV-2. Una solución real coste-efectiva para una crisis sanitaria sin precedentes

Author

Villalonga Vadell, R.M., Sala Blanch, X., Roigé Solé, J., Garcia Eroles, X., Morros Viñoles, C., Valero Castell, R., Bausili Ribera, M., Pedregosa Sanz, A., Sergi Angeles Fite, G., Abreu Paradell, S., Adalia Bartolomé, R., Álvarez Pérez, A., Amigó Bonet, N., Asbert Sagasti, R., Barbal Badia, F., Carramiñana Dominguez, A., Castellnou Ferré, J., Bernia Gil, J.A., Carol Boeris, F., Colomina Soler, M.J., Chamero Pastilla, A., del Moral García, M.V., del Pozo, D., Escolano Villén, F., Esquius Jofre, P., Ferrando Ortolá, C., García Marqueta, C., Hernández Aguado, C., Hernando Pastor, D., Isach Comallonga, N., Isern Domingo, X., Cesar Jaramillo Carrión, L., Koo García, M., Lacambra Basil, M., Lázaro Alcay, J.J., Mailan Bello, J., Manrique Muñoz, S., Martínez Palli, G., Martínez Jérez, L., Masdeu Castellví, J., Mercadal Mercadal, J., Montero Matamala, A., Morales Torres, O., Moret Ferron, M.L., Moret Ruiz, E., Muñoz Falcón, L., de Nadal Clanchet, M., Miquel Ortells Nebot, P., Prat Vallribera, A., Remartinez Fernandez, F., Roca Campos, P., Roldan Osuna, J., Sabaté Pes, A., Sala Francino, P., Saludes Serra, J., Samsó Sabe, E., Sarmiento Meneses, E., Soto Ejarque, J.M., Tomas Torrelles, A., Tomás Esteban, A., and Yuste Graupera, M.

Published
2021
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22. The effect of prenatal smoke exposure on child neuropsychological function: a prospective mother-child cohort study

Author

Universitat Rovira i Virgili, Roigé-Castellví J, Murphy M, Hernández-Martínez C, Solé-Navais P, Cavallé-Busquets P, Fernández-Ballart J, Ballesteros M, Canals J, Universitat Rovira i Virgili, and Roigé-Castellví J, Murphy M, Hernández-Martínez C, Solé-Navais P, Cavallé-Busquets P, Fernández-Ballart J, Ballesteros M, Canals J

Abstract

To study prospectively the effect of prenatal smoke exposure (PSE) on child neuropsychological function and intelligence quotient (IQ).PSE has been associated with adverse effects on child neurodevelopment. However, some studies reported that these associations disappear after adjustment for potential confounders.A cohortof 248 mothers-child dyad was followed from the first trimester of pregnancy until children were 7.5 years old. PSE was recorded during pregnancy by questionnaire and plasma cotinine. The Wechsler Intelligence Scale for Children, the Neuropsychological Assessment of Executive Functions for Children (ENFEN) and the School Neuropsychological Maturity Questionnaire were administered at 7.5 years of age. The effect of PSE on child IQ and neuropsychological function was assessed with ANCOVA, adjusting for obstetric, neonatal and sociodemographic factors.Children whose mothers smoked throughout pregnancy scored lower in interference (ENFEN) compared to unexposed children (F = 4.1; p = .008). The results showed no differences in other executive functions, verbal and visual memory and IQ between the PSE groups.PSE had little effect on child neuropsychological outcome and was limited to mental flexibility. Nevertheless, these findings support further efforts aimed at encouraging mothers to quit smoking in pregnancy.

Published
2020

24. Epidural analgesia in laparoscopic radical prostatectomy

Author

Tejedor-Navarro, A., García-Martínez, M., Vendrell-Jordà, M., Gómez-Lanza, E., García-Aranda, S., and Masdeu-Castellví, J.

Subjects
Laparoscopic prostatectomy, Prostatectomía laparoscópica, complicaciones neurológicas, analgesia epidural, epidural analgesia, neurologic complications, postoperative pain, dolor postoperatorio
Abstract

Introduction: Epidural analgesia is an effective technique for postoperative pain relief. Our aim in this retrospective study was to assess the postoperative pain control and complications relating to epidural technique in laparoscopic radical prostatectomy (LRP). Material and methods: A retrospective analysis of 193 patients who underwent LRP, in which epidural analgesia was the postoperative pain approach, was performed. The procedure is generally performed under combined anesthesia. Data collected was postoperative pain data; appearance of neurological disorders (Bromage scale was used for motor weakness assessment); data related to the epidural technique and possible difficulties when performing it; data on epidural infusion; catheter-related complications; hospital stay, postoperative complications, and outcome. Results: Firstly, average VAS at rest was 1.2 ± 1.6; and upon movement, average VAS was 1.9 ± 1.8 during the hospital stay. Secondly, complications related to epidural technique appeared in 37 % of patients. There were 3 cases of hematic puncture; 3 accidental catheter disconnections; 1 dural puncture, and 1 subdural block. As for neurological secondary effects of local anesthetics in the epidural technique, 56 patients (30.1 %) presented with motor block of one or both lower extremities after surgery, and 5 (2.7 %) with paresthesia. Statistical analysis showed that motor weakness was not related to age, weight, type of local anesthetic used, infusion rate, level of epidural puncture nor length of catheter within the epidural space (p > 0.05). Conclusion: Postoperative epidural analgesia offers excellent analgesic quality but it can be associated with several complications secondary to the use of local anesthetics, which could disagree with the terms of Fast-track surgery. New techniques like the TAP block could offer the same analgesic quality, without the epidural´s technique potential complications. RESUMEN Objetivos: La analgesia epidural es una técnica eficaz para el control del dolor postoperatorio. Nuestro objetivo en este estudio retrospectivo fue evaluar el control del dolor postoperatorio mediante la escala visual analógica del dolor (EVA) y las complicaciones relacionadas con la técnica epidural, en la prostatectomía radical laparoscópica (PRL). Material y métodos: Llevamos a cabo un análisis retrospectivo de 193 pacientes sometidos a PRL, en los que se realizó la técnica epidural analgésica para el control del dolor postoperatorio. El procedimiento se hizo bajo una anestesia combinada. Registramos los datos relacionados con el dolor postoperatorio; la aparición de sintomatología neurológica (la escala de Bromage se utilizó para evaluar la debilidad motora); datos relacionados con la técnica epidural y posibles dificultades al realizarla; datos sobre la infusión epidural, como tipo de anestésico local utilizado; complicaciones relacionadas con el catéter y complicaciones postoperatorias asociadas al mismo, estancia hospitalaria y resultado. Resultados: En primer lugar, durante la estancia hospitalaria de los pacientes, el EVA promedio en reposo fue 1,2 ± 1,6; y durante el movimiento, el EVA promedio fue de 1,9 ± 1,8. En segundo lugar, las complicaciones relacionadas con la técnica epidural aparecieron en el 37 % de los pacientes. Hubo 3 casos de punción hemática; 3 desconexiones accidentales del catéter, 1 punción dural y 1 bloqueo subdural. En cuanto a las complicaciones neurológicas debidas a los efectos secundarios de los anestésicos locales en la técnica epidural, 56 (30,1 %) pacientes presentaron bloqueo motor de una o ambas extremidades inferiores después de la cirugía y 5 (2,7 %) refirieron parestesias. No hubo ninguna complicación neurológica que persistiese tras el alta hospitalaria. El análisis estadístico mostró que la debilidad motora no estaba relacionada con la edad, el peso, el tipo de anestésico local utilizado, la velocidad de infusión, el nivel de punción epidural ni la longitud del catéter en el espacio epidural (p > 0,05). Conclusión: La analgesia epidural postoperatoria ofrece una excelente calidad analgésica, pero puede estar asociada a varias complicaciones secundarias al uso de anestésicos locales, lo que podría estar en contraposición con las tendencias actuales de cirugía fastrack. Las nuevas técnicas emergentes podrían ofrecer la misma calidad analgésica evitando las potenciales complicaciones de la técnica epidural.

Published
2018

25. REVERSAL OF IMMUNE TOLERANCE AND INCREASED SURVIVAL AFTER XPO1 AND BTK INHIBITION IN MOUSE MODELS OF PRIMARY CNS LYMPHOMA (PCNSL)

Author

Jiménez, I., primary, Carabia, J., additional, Bobillo, S., additional, Palacio, C., additional, Abrisqueta, P., additional, Nieto, J.C., additional, Castellví, J., additional, Martínez-Ricarte, F., additional, Escoda, L., additional, Perla, C., additional, Cespedes, D.H., additional, Boix, J., additional, Purroy, N., additional, Puigdefàbregas, L., additional, Seoane, J., additional, Bosch, F., additional, and Crespo, M., additional

Published
2019
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27. Dendritic Cells From the Cervical Mucosa Capture and Transfer HIV-1 via Siglec-1

Author

Perez-Zsolt, D., Cantero, Jon, Erkizia, Itziar, Benet, S., Pino, M., Serra-Peinado, Carla, Hernández Gallego, Alba, Castellví, J., Tapia, G., Arnau-Saz, V., Garrido, J., Tarrats, A., Buzón, M.J., Martinez-Picado, J., Izquierdo-Useros, N., Genescà Ferrer, Meritxell., Perez-Zsolt, D., Cantero, Jon, Erkizia, Itziar, Benet, S., Pino, M., Serra-Peinado, Carla, Hernández Gallego, Alba, Castellví, J., Tapia, G., Arnau-Saz, V., Garrido, J., Tarrats, A., Buzón, M.J., Martinez-Picado, J., Izquierdo-Useros, N., and Genescà Ferrer, Meritxell.

Abstract

Altres ajuts: JM-P and NI-U are supported by the Spanish Secretariat of State of Research, Development and Innovation through grant SAF2016-80033-R. MG is supported by a Marie Curie Career Integration Grant (CIG) from the European Commission and by the Pla estratègic de recerca i innovació en salut (PERIS), from the Catalan government., Antigen presenting cells from the cervical mucosa are thought to amplify incoming HIV-1 and spread infection systemically without being productively infected. Yet, the molecular mechanism at the cervical mucosa underlying this viral transmission pathway remains unknown. Here we identified a subset of HLA-DR+ CD14+ CD11c+ cervical DCs at the lamina propria of the ectocervix and the endocervix that expressed the type-I interferon inducible lectin Siglec-1 (CD169), which promoted viral uptake. In the cervical biopsy of a viremic HIV-1+ patient, Siglec-1+ cells harbored HIV-1-containing compartments, demonstrating that in vivo, these cells trap viruses. Ex vivo, a type-I interferon antiviral environment enhanced viral capture and trans-infection via Siglec-1. Nonetheless, HIV-1 transfer via cervical DCs was effectively prevented with antibodies against Siglec-1. Our findings contribute to decipher how cervical DCs may boost HIV-1 replication and promote systemic viral spread from the cervical mucosa, and highlight the importance of including inhibitors against Siglec-1 in microbicidal strategies.

Published
2019

30. Productive HIV-1 infection upregulates CD32 in vitro and in vivo

Author

Serra Peinado, C., primary, Grau-Expósito, J., additional, Falcó, V., additional, Genescà, M., additional, Martinez-Picado, L.J., additional, Luque-Ballesteros, L., additional, Astorga, A., additional, Gálvez, C., additional, Castellví, J., additional, Willekens, R., additional, Ocaña, I., additional, Burgos, J., additional, Navarro, J., additional, Curran, A., additional, Ribera, E., additional, Montaner, L., additional, Martinez-Picado, J., additional, and Buzon, M.J., additional

Published
2017
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31. Post-transplant monomorphic Burkitt's lymphoma: Clinical characteristics and outcome of a multicenter series

Author

Bobillo, S., primary, Abrisqueta, P., additional, Sánchez-González, B., additional, Giné, E., additional, Romero, S., additional, Alcoceba, M., additional, González-Barca, E., additional, González de Villambrosía, S., additional, Sancho, J.M., additional, Castellví, J., additional, López, A., additional, and Bosch, F., additional

Published
2017
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34. Lipoma of the Uterine Corpus: Exceptional Eventuality Combined with an Ovarian Thecoma

Author

Vilallonga, R., García, A., Castellví, J., Fort, J. M., Armengol, M., and y Cajal, S. Ramón

Subjects
body regions, Article Subject, otorhinolaryngologic diseases, female genital diseases and pregnancy complications
Abstract

Uterine lipomas are very uncommon with symptoms that are similar to leiomyomas. Their diagnosis is always histological although some radiological methods may suggest their existence prior to surgery. They are sometimes associated with endometrial pathology, but there are no previous reported cases related to ovarian thecoma. Their prognosis is excellent. Clinical, radiological, morphologic, and immunohistochemical findings are shown which correspond to uterine lipoma associated with endometrial polyps and ovarian thecoma.

Published
2009
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36. EL INTERES GEOGRAFICO DE LOS DOCUMENTOS HISTÓRICOS EN LA EXPLICACIÓN CIENTÍFICA DEL FOCO GLACIAR DEL CORRAL DEL VELETA (SIERRA NEVADA, ESPAÑA) DURANTE LA PEQUEÑA EDAD DEL HIELO.

Author

GÓMEZ-ORTIZ, A., OLIVA, M., SALVADOR-FRANCH, F., SALVÀ-CATARINEU, M., and PLANA-CASTELLVÍ, J. A.

Abstract

Copyright of Cuadernos de Investigación Geográfica is the property of Universidad de la Rioja, Servicio de Publicaciones and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2018
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48. Isolation and Characterization of Thermophilic Bacillusspp. from Geothermal Environments on Deception Island, South Shetland Archipelago

Author

Llarch, À., Logan, N.A., Castellví, J., Prieto, M.J., and Guinea, J.

Abstract

Ten bacterial strains isolated from water and sediment samples taken from geothermal areas of Deception Island, in the South Shetland archipelago, were found to represent six distinct types of thermophilic, Gram-positive, aerobic, catalase positive, endospore-forming rods, identified as Bacillussp. Six representative strains were subjected to routine phenotypic characterization, numerical taxonomic, and chemotaxonomic analyses. Two isolates were identified as thermophilic strains of B. licheniformisand B. megaterium,but the four other strains could not be identified as known species of Bacillusand, hence, may represent new ones.

Published
1997
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50. Sedimentation on the Valencia Continental Shelf: Preliminary results.

Author

Maldonado, Antonio, Swift, D., Young, R., Han, G., Nittrouer, C., Master, D. de, Rey-Salgado, Jorge, Palomo-Pedraza, Carlos, Acosta-Yepes, Juan, Ballester, A., Castellví, J., Maldonado, Antonio, Swift, D., Young, R., Han, G., Nittrouer, C., Master, D. de, Rey-Salgado, Jorge, Palomo-Pedraza, Carlos, Acosta-Yepes, Juan, Ballester, A., and Castellví, J.

Abstract

Preliminary analysis of data collected during the course of a cooperative Spanish-United States investigation of the Valencia Shelf (western Mediterranean) reveals a storm-dominated, mud-accumulating sedimentary regime. Calcareous mud is accumulating seaward of a narrow band of shoreface sand and gravel. On the outer shelf the mud is enriched by a pelagic calcareous component. Preliminary210Pb data from vertical profiles of box cores yield nominal accumulation rates from 2.6 mm y−1 near the Ebro Delta to 1.3 mm y−1 on the southern portion of the Valencia Shelf. Storm-current winnowing has resulted in the development of a biogenic lag sand over the mid-shelf mud in the northern part of the study area. Piston cores reveal a basal Holocene sand and gravel facies similar to that presently seen on the inner shelf. Upward-fining sequences on the central and outer shelf are inferred to result from the landward shift of lithotopes during the course of the Holocene transgression. These sequences are locally repeated, perhaps as the consequence of brief, local interludes of coastal progradation. Application of a diagnostic circulation model suggests that intense, downwelling coastal flows occur during winter northeastern storms. Storm activity has induced erosional shoreface retreat during the course of the Holocene transgression and has generated by this means the basal coarse facies observed in the piston cores. In the central part of the study area seaward of the Albufera Lagoon, the mud blanket thins to a layer several centimeters thick which is draped over a thickened (10 m) basal sand. The basal sand is molded into northwest trending ridges. The data are not sufficient to determine whether these are overstepped barriers, or submarine sand ridges formed by storm flows during the shoreface retreat process.

Published
1983

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