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509 results on '"Castellano, R."'

3. Renal Perfusion During Aortic Surgery: Looking for the Ideal Substrate : Curitiba Trial Investigators

Author

Tshomba, Y., Simonini, E., Colombo, E., Ardita, V., Apruzzi, L., Rinaldi, E., Pasin, L., Cambiaghi, T., Catenaccio, B., Castellano, R., Venturini, M., Landoni, G., Nardelli, P., Leopardi, M., Espinar, E., Salvati, S., Lembo, R., Baccellieri, D., Bertoglio, L., Kahlberg, A., Bossi, S., Melissano, G., Chiesa, Roberto, Tshomba, Yamume, editor, Baccellieri, Domenico, editor, and Chiesa, Roberto, editor

Published
2019
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7. A chemogenomic approach to identify personalized therapy for patients with relapse or refractory acute myeloid leukemia: results of a prospective feasibility study

Author

Collignon, A., Hospital, M. A., Montersino, C., Courtier, F., Charbonnier, A., Saillard, C., D’Incan, E., Mohty, B., Guille, A., Adelaïde, J., Carbuccia, N., Garnier, S., Mozziconacci, M. J., Zemmour, C., Pakradouni, J., Restouin, A., Castellano, R., Chaffanet, M., Birnbaum, D., Collette, Y., and Vey, N.

Published
2020
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8. Variation in the COVID-19 infection–fatality ratio by age, time, and geography during the pre-vaccine era: a systematic analysis

Author

Sorensen, Rjd, Barber, Rm, Pigott, Dm, Carter, A, Spencer, Cn, Ostroff, Sm, Reiner, Rc, Abbafati, C, Adolph, C, Allorant, A, Amlag, Jo, Aravkin, Ay, Bachmeier, Sd, Bang-Jensen, Bl, Bisignano, C, Bloom, Ss, Castellano, R, Castro, E, Collins, Jk, Comfort, H, Dai, Xc, Dangel, Wj, Dapper, C, Deen, A, Earl, L, Erickson, M, Ewald, Sb, Ferrari, Aj, Flaxman, Ad, Frostad, Jj, Fullman, N, Gamkrelidze, A, Giles, Jr, Guo, Gr, Jw, He, Helak, M, Hulland, En, Huntley, Bm, Kereselidze, M, Lazzar-Atwood, A, Legrand, Ke, Lindstrom, A, Linebarger, E, Lozano, R, Magistro, B, Malta, Dc, Mansson, J, Herrera, Amm, Marinho, F, Mirkuzie, Ah, Mokdad, Ah, Monasta, L, Naghavi, M, Nassereldine, H, Nomura, S, Odell, Cm, Olana, Lt, Pasovic, M, Pease, Sa, Penberthy, L, Reinke, G, Ribeiro, Alp, Santomauro, Df, Sholokhov, A, Skhvitaridze, N, Spurlock, Ee, Syailendrawati, R, Topor-Madry, R, At, Vo, Vos, T, Walcott, R, Walker, A, Watson, S, Wiysonge, Cs, Worku, Na, Zheng, P, Hay, Si, Gakidou, E, and Murray, Cjl

Subjects
infection fatality ratio, covid, General Medicine, vaccination
Published
2022

9. Les anticorps monoclonaux chimériques anti-ICOS 314.8 inhibent les cellules tumorales et les lymphocytes T régulateurs dans le syndrome de Sézary

Author

Amatore, F., primary, Barré, M., additional, Orlanducci, F., additional, Lopez, M., additional, Castellano, R., additional, Ram-Wolff, C., additional, Gorvel, L., additional, Goubard, A., additional, Gaudy-Marqueste, C., additional, Bagot, M., additional, Bensussan, A., additional, Delaporte, E., additional, and Olive, D., additional

Published
2022
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10. Chimerized anti-ICOS 314.8 monoclonal antibodies inhibit tumor cells and regulatory T cells in patients with Sézary syndrome

Author

Amatore, FA, primary, Barre, M, additional, Orlanducci, F, additional, Lopez, M, additional, Castellano, R, additional, Ram-Wolff, C, additional, Gorvel, L, additional, Goubard, A, additional, Gaudy-Marqueste, C, additional, Bagot, M, additional, Bensussan, A, additional, Delaporte, E, additional, and Olive, D, additional

Published
2022
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12. Targeting CISH enhances natural cytotoxicity receptor signaling and reduces NK cell exhaustion to improve solid tumor immunity

Author

Bernard, P-L, Delconte, R, Pastor, S, Laletin, V, Da Silva, CC, Goubard, A, Josselin, E, Castellano, R, Krug, A, Vernerey, J, Devillier, R, Olive, D, Verhoeyen, E, Vivier, E, Huntington, ND, Nunes, J, Guittard, G, Bernard, P-L, Delconte, R, Pastor, S, Laletin, V, Da Silva, CC, Goubard, A, Josselin, E, Castellano, R, Krug, A, Vernerey, J, Devillier, R, Olive, D, Verhoeyen, E, Vivier, E, Huntington, ND, Nunes, J, and Guittard, G

Abstract

BACKGROUND: The success and limitations of current immunotherapies have pushed research toward the development of alternative approaches and the possibility to manipulate other cytotoxic immune cells such as natural killer (NK) cells. Here, we targeted an intracellular inhibiting protein 'cytokine inducible SH2-containing protein' (CISH) in NK cells to evaluate the impact on their functions and antitumor properties. METHODS: To further understand CISH functions in NK cells, we developed a conditional Cish-deficient mouse model in NK cells (Cishfl/flNcr1Ki/+ ). NK cells cytokine expression, signaling and cytotoxicity has been evaluated in vitro. Using intravenous injection of B16F10 melanoma cell line and EO711 triple negative breast cancer cell line, metastasis evaluation was performed. Then, orthotopic implantation of breast tumors was performed and tumor growth was followed using bioluminescence. Infiltration and phenotype of NK cells in the tumor was evaluated. Finally, we targeted CISH in human NK-92 or primary NK cells, using a technology combining the CRISPR(i)-dCas9 tool with a new lentiviral pseudotype. We then tested human NK cells functions. RESULTS: In Cishfl/flNcr1Ki/+ mice, we detected no developmental or homeostatic difference in NK cells. Global gene expression of Cishfl/flNcr1Ki/+ NK cells compared with Cish+/+Ncr1Ki/+ NK cells revealed upregulation of pathways and genes associated with NK cell cycling and activation. We show that CISH does not only regulate interleukin-15 (IL-15) signaling pathways but also natural cytotoxicity receptors (NCR) pathways, triggering CISH protein expression. Primed Cishfl/flNcr1Ki/+ NK cells display increased activation upon NCR stimulation. Cishfl/flNcr1Ki/+ NK cells display lower activation thresholds and Cishfl/flNcr1Ki/+ mice are more resistant to tumor metastasis and to primary breast cancer growth. CISH deletion favors NK cell accumulation to the primary tumor, optimizes NK cell killing properties and decreases T

Published
2022

16. Evaluating the determinants of environmentally-significant behaviour in Europe

Author

Punzo, G., Demetrio Panarello, Pagliuca, M. M., Castellano, R., and Punzo G., Panarello D., Pagliuca M.M., Castellano R.

Subjects
Felt responsibility, Eco-Innovation Index, Pro-environmental behaviour, Perceived values, Felt responsibility, Structural equation modelling, Eco-Innovation Index, Structural equation modelling, Pro-environmental behaviour, Perceived values
Abstract

This paper explores how citizens' perceived values and felt responsibility affect pro-environmental behaviours in the EU-28 countries, grouped according to the quartile distribution of the EU Eco-Innovation Index 2017. An SEM is tested on Eurobarometer data (2017), revealing interesting differences across the four groups which can help policy-makers in implementing well-designed strategies.

Published
2020

18. An optimization model for minimizing systemic risk

Author

Castellano, R, Cerqueti, R, Clemente, G, Grassi, R, Castellano, Rosella, Cerqueti, Roy, Clemente, Gian Paolo, Grassi, Rosanna, Castellano, R, Cerqueti, R, Clemente, G, Grassi, R, Castellano, Rosella, Cerqueti, Roy, Clemente, Gian Paolo, and Grassi, Rosanna

Abstract

This paper proposes an optimal allocation model with the main aim to minimize systemic risk related to the sovereign risk of a set of countries. The reference methodological environment is that of complex networks theory. Specifically, we consider the weighted clustering coefficient as a proxy of systemic risk, while the interconnections among countries are captured by the relationships among default probabilities of the set of countries under consideration. The selected optimization criterion is based on minimization of the mean absolute deviation. We perform empirical analyses to validate the theoretical predictions, and interpret the findings in the context of the proposed model.

Published
2021

25. Evaluating the attitudes of Europeans towards the environment

Author

Punzo, G., Demetrio Panarello, Pagliuca, M. M., Castellano, R., and Punzo G., Panarello D., Pagliuca M.M., Castellano R.

Subjects
Eco-Innovation Index, Pro-environmental behaviour, Perceived values, Structural equation modelling, Eco-Innovation Index, Structural equation modelling, Pro-environmental behaviour, Perceived values
Abstract

This paper explores how citizens’ perceived values and felt responsibility affect pro-environmental behaviours in the EU countries, grouped according to the quartile distribution of the EU Eco-Innovation Index 2017. An SEM is tested on Eurobarometer data (2017), revealing interesting differences across the four groups which can help policy-makers in implementing well-designed strategies.

Published
2019

28. Targeting CISH enhances natural cytotoxicity receptor signaling and reduces NK cell exhaustion to improve solid tumor immunity

Author

Bernard, P-L., primary, Delconte, R. B., additional, Pastor, S., additional, Laletin, V., additional, Costa Da Silva, C., additional, Goubard, A., additional, Josselin, E., additional, Castellano, R., additional, Krug, A., additional, Vernerey, J., additional, Devillier, R., additional, Olive, D., additional, Verhoeyen, E., additional, Vivier, E., additional, Huntington, N. D., additional, Nunès, J. A., additional, and Guittard, G., additional

Published
2021
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29. An optimization model for minimizing systemic risk

Author

Castellano, R., Cerqueti, Roy, Clemente, Gian Paolo, Grassi, R., Cerqueti R., Clemente G. P. (ORCID:0000-0001-6795-4595), Castellano, R., Cerqueti, Roy, Clemente, Gian Paolo, Grassi, R., Cerqueti R., and Clemente G. P. (ORCID:0000-0001-6795-4595)

Abstract

This paper proposes an optimal allocation model with the main aim to minimize systemic risk related to the sovereign risk of a set of countries. The reference methodological environment is that of complex networks theory. Specifically, we consider the weighted clustering coefficient as a proxy of systemic risk, while the interconnections among countries are captured by the relationships among default probabilities of the set of countries under consideration. The selected optimization criterion is based on minimization of the mean absolute deviation. We perform empirical analyses to validate the theoretical predictions, and interpret the findings in the context of the proposed model.

Published
2020

31. A syntenin-deficient microenvironment educates AML for aggressiveness

Author

Leblanc, R, primary, Fares, J, additional, Goubard, A, additional, Castellano, R, additional, Camoin, L, additional, Balzano, M, additional, Ghossoub, R, additional, Bou-Tayeh, B, additional, Fauriat, C, additional, Vey, N, additional, Borg, JP, additional, Collette, Y, additional, Aurrand-Lions, M, additional, David, G, additional, and Zimmermann, P, additional

Published
2021
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32. ICOS est fortement exprimé dans les lymphomes T cutanés épidermotropes et son ciblage permet l’inhibition des cellules tumorales

Author

Amatore, F., primary, Ortonne, N., additional, Lopez, M., additional, Orlanducci, F., additional, Castellano, R., additional, Ingen-Housz-Oro, S., additional, De Croos, A., additional, Gorvel, L., additional, Goubard, A., additional, Salvado, C., additional, Bouabdallah, R., additional, Bonnet, N., additional, Grob, J.-J., additional, Gaulard, P., additional, Bagot, M., additional, Bensussan, A., additional, Berbis, P., additional, and Olive, D., additional

Published
2020
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34. Understanding pro-environmental travel behaviours in Western Europe

Author

Punzo, G., Castellano, R., Demetrio Panarello, and Punzo G., Castellano R., Panarello D.

Subjects
Cross-country comparison, Gender-based analysis, Sustainable transport, Sustainable transport, Cross-country comparison, Gender-based analysis
Abstract

This study aims at understanding, from a gender perspective, the reasons behind citizens’ choice of using public transport, and whether this choice is driven by pro-environmental behaviour. Using Eurobarometer data (2013), we perform ordered logistic regressions comparatively for Germany, Italy and the Netherlands. Financial, political and environmental factors are shown to have significant roles in shaping travel behaviours, with interesting gender and cross-country differences.

Published
2018

37. Renal Perfusion During Aortic Surgery: Looking for the Ideal Substrate

Author

Tshomba, Y., Simonini, E., Colombo, E., Ardita, V., Apruzzi, L., Rinaldi, E., Pasin, L., Cambiaghi, T., Catenaccio, B., Castellano, R., Venturini, M., Landoni, G., Nardelli, P., Leopardi, M., Espinar, E., Salvati, S., Lembo, R., Baccellieri, D., Bertoglio, L., Kahlberg, A., Bossi, S., Melissano, G., and Chiesa, Roberto

Published
2019

43. THE VALUE OF HYBRID DEBRANCHING

Author

CHIESA, ROBERTO, Castellano R, Mascia D, TSHOMBA, YAMUME, MELISSANO, GERMANO, KAHLBERG , ANDREA LUITZ, Roger M. Greenhalgh, Chiesa, Roberto, Kahlberg, ANDREA LUITZ, Castellano, R, Mascia, D, Tshomba, Yamume, and Melissano, Germano

Published
2016

47. Aortic surgery at San Raffaele Hospital

Author

Chiesa R, Castellano R, Civilini E, Marone EM, TSHOMBA, YAMUME, MELISSANO , GERMANO, Chiesa R, Melissano G, Setacci C, Argenteri A, Chiesa, R, Melissano, Germano, Castellano, R, Civilini, E, Marone, Em, and Tshomba, Yamume

Published
2014

49. A robust and rapid xenograft model to assess efficacy of chemotherapeutic agents for human acute myeloid leukemia

Author

Saland, E, Boutzen, H, Castellano, R, Pouyet, L, Griessinger, E, Larrue, C, de Toni, F, Scotland, S, David, Mathieu, Danet-Desnoyers, G, Vergez, F, Barreira, Y, Collette, Yves, Récher, C, Sarry, J-E, Centre de Recherches en Cancérologie de Toulouse (CRCT), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), IUT de Tarbes, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Centre de Recherche en Cancérologie de Marseille (CRCM), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Aix Marseille Université (AMU), Centre méditerranéen de médecine moléculaire (C3M), Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Medicine, Perelman School of Medicine, University of Pennsylvania [Philadelphia]-University of Pennsylvania [Philadelphia], Service d'Expérimentation Animale, UMS006, CHU Toulouse [Toulouse], Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Toulouse (UT)-Université de Toulouse (UT), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA), University of Pennsylvania-University of Pennsylvania, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM), and HAL AMU, Administrateur

Subjects
BUSULFAN, ENGRAFTMENT, [SDV.CAN] Life Sciences [q-bio]/Cancer, NOD/SCID MICE, TRANSPLANTATION, hemic and lymphatic diseases, IMMUNODEFICIENT MICE, CELLS, [SDV.CAN]Life Sciences [q-bio]/Cancer, HEMATOPOIESIS, neoplasms, IRRADIATION
Abstract

International audience; Relevant preclinical mouse models are crucial to screen new therapeutic agents for acute myeloid leukemia (AML). Current in vivo models based on the use of patient samples are not easy to establish and manipulate in the laboratory. Our objective was to develop robust xenograft models of human AML using well-characterized cell lines as a more accessible and faster alternative to those incorporating the use of patient-derived AML cells. Five widely used AML cell lines representing various AML subtypes were transplanted and expanded into highly immunodeficient non-obese diabetic/LtSz-severe combined immunodeficiency IL2R gamma(null)(c) mice (for example, cell line-derived xenografts). We show here that bone marrow sublethal conditioning with busulfan or irradiation has equal efficiency for the xenotransplantation of AML cell lines. Although higher number of injected AML cells did not change tumor engraftment in bone marrow and spleen, it significantly reduced the overall survival in mice for all tested AML cell lines. On the basis of AML cell characteristics, these models also exhibited a broad range of overall mouse survival, engraftment, tissue infiltration and aggressiveness. Thus, we have established a robust, rapid and straightforward in vivo model based on engraftment behavior of AML cell lines, all vital prerequisites for testing new therapeutic agents in preclinical studies.

Published
2015

50. Lend Me Your Voice – A Constructivist Approach to Augmentative Communication

Author

Lytras, MD, Pablos, P, Ziderman, A, Roulstone, A, Maurer, H, Imber, JB, Ordoñez De Pablos, P, Mangiatordi, A, Acosta, M, Castellano, R, MANGIATORDI, ANDREA, Castellano, R., Lytras, MD, Pablos, P, Ziderman, A, Roulstone, A, Maurer, H, Imber, JB, Ordoñez De Pablos, P, Mangiatordi, A, Acosta, M, Castellano, R, MANGIATORDI, ANDREA, and Castellano, R.

Abstract

This paper envisions a software project dedicated to disabled children with communication impairments or restrictions. The idea is to develop a costless and functional communication aid capable of voice output. This software could be a very convenient solution if used on the laptops provided by One Laptop Per Child to children in different developing countries. These laptops, together with their operating system, are designed following constructionist ideas, focused on cooperative learning and learning learning . This work discusses the creation of a tool which is both an aid to the disabled children and a base on which inclusive context can be built in school classes. An ideal lesson plan is discussed which could be used as a guideline for teachers.

Published
2010

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