Search

Your search keyword '"Castel S"' showing total 253 results
Start Over Author "Castel S"
253 results on '"Castel S"'

9. Relationship between Plasma and Intracellular Concentrations of Bedaquiline and Its M2 Metabolite in South African Patients with Rifampin-Resistant Tuberculosis

Author

Ngwalero, P., Brust, J.C.M., Beek, S.W. van, Wasserman, S., Maartens, G., Meintjes, G., Joubert, A., Norman, J., Castel, S., Gandhi, N.R., Denti, P., McIlleron, H., Svensson, E.M., Wiesner, L., Ngwalero, P., Brust, J.C.M., Beek, S.W. van, Wasserman, S., Maartens, G., Meintjes, G., Joubert, A., Norman, J., Castel, S., Gandhi, N.R., Denti, P., McIlleron, H., Svensson, E.M., and Wiesner, L.

Abstract

Contains fulltext : 244688.pdf (Publisher’s version ) (Open Access), Bedaquiline is recommended for the treatment of all patients with rifampin-resistant tuberculosis (RR-TB). Bedaquiline accumulates within cells, but its intracellular pharmacokinetics have not been characterized, which may have implications for dose optimization. We developed a novel assay using high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) to measure the intracellular concentrations of bedaquiline and its primary metabolite M2 in patients with RR-TB in South Africa. Twenty-one participants were enrolled and underwent sparse sampling of plasma and peripheral blood mononuclear cells (PBMCs) at months 1, 2, and 6 of treatment and at 3 and 6 months after bedaquiline treatment completion. Intensive sampling was performed at month 2. We used noncompartmental analysis to describe plasma and intracellular exposures and a population pharmacokinetic model to explore the relationship between plasma and intracellular pharmacokinetics and the effects of key covariates. Bedaquiline concentrations from month 1 to month 6 of treatment ranged from 94.7 to 2,540 ng/ml in plasma and 16.2 to 5,478 ng/ml in PBMCs, and concentrations of M2 over the 6-month treatment period ranged from 34.3 to 496 ng/ml in plasma and 109.2 to 16,764 ng/ml in PBMCs. Plasma concentrations of bedaquiline were higher than those of M2, but intracellular concentrations of M2 were considerably higher than those of bedaquiline. In the pharmacokinetic modeling, we estimated a linear increase in the intracellular-plasma accumulation ratio for bedaquiline and M2, reaching maximum effect after 2 months of treatment. The typical intracellular-plasma ratios 1 and 2 months after start of treatment were 0.61 (95% confidence interval [CI]: 0.42 to 0.92) and 1.10 (95% CI: 0.74 to 1.63) for bedaquiline and 12.4 (95% CI: 8.8 to 17.8) and 22.2 (95% CI: 15.6 to 32.3) for M2. The intracellular-plasma ratios for both bedaquiline and M2 were decreased by 54% (95% CI: 24 to 72%) in HIV-positive patien

Published
2021

23. Noninvasive pigment identification in single cells from living phototrophic biofilms by confocal imaging spectrofluorometry

Author

Roldan, M., Thomas, F., Castel, S., Quesada, A., and Hernandez-Marine M.

Subjects
Scanning electron microscopes -- Analysis, Biological sciences
Abstract

Analysis of fluorescent pigments of a single cell is made with a new imaging technique based on confocal scanning laser microscopy. This technique is used along with a spectrofluorometric detector.

Published
2004

24. Cyclic Vomiting Syndrome is characterized by altered functional brain connectivity of the insular cortex: A cross-comparison with migraine and healthy adults

Author

Ellingsen, D.-M., primary, Garcia, R. G., additional, Lee, J., additional, Lin, R. L., additional, Kim, J., additional, Thurler, A. H., additional, Castel, S., additional, Dimisko, L., additional, Rosen, B. R., additional, Hadjikhani, N., additional, Kuo, B., additional, and Napadow, V., additional

Published
2016
Full Text
View/download PDF

25. Status of R&D on Micromegas for Rare Event Searches : The T-REX project

Author

I.G. Irastorza, J. Castel, S. Cebrixe1n, T. Dafni, G. Fanourakis, E. Ferrer-Ribas, D. Fortuxf1o, L. Esteban, J. Galxe1n, J.A. Garcxeda, A. Gardikiotis, J.G. Garza, T. Geralis, I. Giomataris, H. Gxf3mez, D.C. Herrera, F.J. Iguaz, G. Luzxf3n, J.P. Mols, A. Ortiz, T. Papaevangelou, A. Rodrxedguez, J. Ruz, L. Segui, A. Tomxe1s, T. Vafeiadis and S.C. Yildiz

Published
2012

26. PP.16.39

Author

Jones, E., primary, Decloedt, E., additional, Blockman, M., additional, Sturrock, E., additional, Lesosky, M., additional, Wiesner, L., additional, Castel, S., additional, Schwager, S., additional, and Rayner, B., additional

Published
2015
Full Text
View/download PDF

27. Tolérance et efficacité de la transfusion autologue différée en chirurgie cardiovasculaire

Author

Massonnet-Castel S, E. Pelissier, M.F. Fruchart, and B. Abry

Subjects
Tourniquet, medicine.medical_specialty, Intraoperative blood salvage, business.industry, medicine.medical_treatment, Autologous blood, Albumin, General Medicine, medicine.disease, Surgery, Angina, Pneumonia, Anesthesiology and Pain Medicine, Anesthesia, medicine, Blood units, business, Fluid replacement
Abstract

Over a period of 18 months, 313 patients (mean age 52 years) undergoing elective cardiovascular surgery were included in the autologous transfusion program involving two different Transfusion Centres. A further 10 patients were excluded because of anaemia (haemoglobin levels < 11 g · dl−1) (n = 3), angina pectoris less than 8 days before (n = 3), patient refusal (n = 2), pneumonia (n = 1), and severe aortic insufficiency (n = 1). A maximum of 5 ml · kg−1 of blood was obtained during the 3 to 4 weeks prior to surgery, one donation being taken a week. In one Transfusion Centre, the blood was taken without tourniquet, and without any fluid replacement. Diuretics and converting enzyme inhibitors were stopped. In the opposite, in the other Centre, blood was taken using a tourniquet, and replaced by a gelatin solution (Plasmion ®). All the patients were given iron. The blood units were kept by the Transfusion Centres under the same conditions as homologous blood, but in a separate circuit. The 313 patients predeposited a mean of 2.71 units of blood : 4 units where obtained in 59 patients, 3 in 113, 2 in 133 and only 1 in 8. Mean haemoglobin level on starting the program was 14.49 g · dl−1. Neither homologous red cells nor plasma was administered in 176 patients (56.23 %) ; among the 172 patients who predeposited 3 or 4 units, 123 (71.5 %) were given their own blood only. Intraoperative blood salvage was used in 189 out of 313 patients (60.4 %), and intraoperative haemodilution with albumin was used in 173 patients. This technique was not more expensive than homologous transfusion, but it ought to be used with the other techniques of blood saving. Autologous blood transfusion not only relieves the strain on the transfusion service, and saves money, but also saves time with crossmatching. Moreover, it reassures patients that they are not at risk of transfusion adverse reactions, or being infected with the AIDS or hepatitis viruses.

Published
1990

28. Cyclic Vomiting Syndrome is characterized by altered functional brain connectivity of the insular cortex: A cross-comparison with migraine and healthy adults.

Author

Ellingsen, D.‐M., Garcia, R. G., Lee, J., Lin, R. L., Kim, J., Thurler, A. H., Castel, S., Dimisko, L., Rosen, B. R., Hadjikhani, N., Kuo, B., and Napadow, V.

Subjects
VOMITING, INSULAR cortex, MIGRAINE, FUNCTIONAL magnetic resonance imaging, HEALTH of adults, DIAGNOSIS
Abstract

Cyclic Vomiting Syndrome ( CVS) has been linked to episodic migraine, yet little is known about the precise brain-based mechanisms underpinning CVS, and whether these associated conditions share similar pathophysiology. We investigated the functional integrity of salience ( SLN) and sensorimotor ( SMN) intrinsic connectivity networks in CVS, migraine and healthy controls using brain functional Magnetic Resonance Imaging. CVS, relative to both migraine and controls, showed increased SLN connectivity to middle/posterior insula, a key brain region for nausea and viscerosensory processing. In contrast, this same region showed diminished SMN connectivity in both CVS and migraine. These results highlight both unique and potentially shared pathophysiology between these conditions, and suggest a potential target for therapeutics in future studies. [ABSTRACT FROM AUTHOR]

Published
2017
Full Text
View/download PDF

30. International standards for programmes of training in intensive care medicine in Europe

Author

Bullock, A, Wilde, J D, Bion, J F, Clutton-Brock, T, Flaatten, H, Mathy, B, van Mook, W, Schuwirth, L, Marsh, B, Phelan, D, Shippey, B, Nimmo, G, Castel, S, Hillion, Y, Bonnet, J, Chaumont, D, Rothen, H U, Reay, H, Krenn, C, Germann, P, Ferdinande, P, de Backer, D, Smilov, I, Keremidchieva, N, Gasparoviae, V, Radonic, R, Kyprianou, T, Kakas, M, Sramek, V, Rubertsson, Sten, m.fl., (et al), Bullock, A, Wilde, J D, Bion, J F, Clutton-Brock, T, Flaatten, H, Mathy, B, van Mook, W, Schuwirth, L, Marsh, B, Phelan, D, Shippey, B, Nimmo, G, Castel, S, Hillion, Y, Bonnet, J, Chaumont, D, Rothen, H U, Reay, H, Krenn, C, Germann, P, Ferdinande, P, de Backer, D, Smilov, I, Keremidchieva, N, Gasparoviae, V, Radonic, R, Kyprianou, T, Kakas, M, Sramek, V, Rubertsson, Sten, and m.fl., (et al)

Abstract

PURPOSE: To develop internationally harmonised standards for programmes of training in intensive care medicine (ICM). METHODS: Standards were developed by using consensus techniques. A nine-member nominal group of European intensive care experts developed a preliminary set of standards. These were revised and refined through a modified Delphi process involving 28 European national coordinators representing national training organisations using a combination of moderated discussion meetings, email, and a Web-based tool for determining the level of agreement with each proposed standard, and whether the standard could be achieved in the respondent's country. RESULTS: The nominal group developed an initial set of 52 possible standards which underwent four iterations to achieve maximal consensus. All national coordinators approved a final set of 29 standards in four domains: training centres, training programmes, selection of trainees, and trainers' profiles. Only three standards were considered immediately achievable by all countries, demonstrating a willingness to aspire to quality rather than merely setting a minimum level. Nine proposed standards which did not achieve full consensus were identified as potential candidates for future review. CONCLUSIONS: This preliminary set of clearly defined and agreed standards provides a transparent framework for assuring the quality of training programmes, and a foundation for international harmonisation and quality improvement of training in ICM.

Published
2011
Full Text
View/download PDF

50. Partial Reversal of Low Molecular Weight Heparin (PK 10169) Anti-Xa Activity by Protamine Sulfate: In vitro and in vivo Study during Cardiac Surgery with Extracorporeal Circulation

Author

J Swanson, E. Terrier, E. Pelissier, Alain Carpentier, Massonnet-Castel S, M. Samama, P Guibourt, B. Abry, Jaulmes B, and L Bara

Subjects
Adult, Male, Extracorporeal Circulation, Protamine sulfate, Adolescent, medicine.drug_class, Low molecular weight heparin, In Vitro Techniques, Pharmacology, In vivo, Physiology (medical), medicine, Humans, Protamines, Blood Coagulation, medicine.diagnostic_test, biology, Heparin, Chemistry, Extracorporeal circulation, Heparin Antagonists, Hematology, Middle Aged, Protamine, Molecular Weight, Coagulation, Anesthesia, Factor X, Factor Xa, biology.protein, Female, Partial Thromboplastin Time, medicine.drug, Partial thromboplastin time
Abstract

Neutralization of a low molecular weight (LMW) heparin fraction by protamine sulfate was evaluated in vitro and in vivo. Anti-Xa and anti-IIa activities were measured by amidolytic and coagulation methods (activated partial thromboplastin time, APTT). Fifteen patients (4 males and 11 females) underwent surgery with extracorporeal circulation. In vitro, anti-Xa and anti-IIa activities and APTT of unfractionated heparin were neutralized with a protamine/heparin (P/H) gravimetric ratio of 1.6, 1.33 and about 2, respectively. Anti-IIa activity and APTT induced by PK 10169 were completely corrected at a P/H ratio of 1 and 2, respectively, while anti-Xa activity was incompletely neutralized at a ratio of 5. In vivo, in 9 patients who did not receive intravenous protamine sulfate, a good correlation was found between doses of PK 10169 infused, anti-IIa plasma level and blood loss. In 3 patients who were treated prophylactically with protamine, bleeding was normal or only slightly increased. In 3 patients who received protamine because of hemorrhage, mean anti-Xa and anti-IIa were 2.3 and 0.54 U before and 1.32–0.06 U after neutralization. Bleeding was stopped by a second dose of protamine in 1 patient, but blood loss was abnormal in the other patients. However, a correlation between bleeding and anti-Xa or anti-IIa activities was not clearly evident.

Published
1986

Catalog

Books, media, physical & digital resources
See catalog results