22 results on '"Castel‐Lavilla, María A."'
Search Results
2. Uso de un sistema extracorpóreo de asistencia circulatoria de flujo continuo, corta duración e inserción quirúrgica como puente a trasplante
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Cabezón-Villalba, Gonzalo, Barge-Caballero, Eduardo, González-Vílchez, Francisco, Castel-Lavilla, María Ángeles, Gómez-Bueno, Manuel, Almenar-Bonet, Luis, González-Costello, José, Lambert-Rodríguez, José Luis, Martínez-Sellés, Manuel, de la Fuente-Galán, Luis, Mirabet-Pérez, Sonia, García-Cosío Carmena, María Dolores, Hervás-Sotomayor, Daniela, Rangel-Sousa, Diego, Blasco-Peiró, Teresa, Garrido-Bravo, Iris P., Rábago Juan-Aracil, Gregorio, Muñiz, Javier, and Crespo-Leiro, María G.
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- 2024
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3. Prevalence, Characteristics, and Prognostic Relevance of Donor-Transmitted Coronary Artery Disease in Heart Transplant Recipients
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Couto-Mallón, David, Almenar-Bonet, Luis, Barge-Caballero, Eduardo, Hernández-Pérez, Francisco José, López-Azor García, Juan Carlos, Valero-Masa, María Jesús, Castel-Lavilla, María Ángeles, Mirabet-Pérez, Sonia, Garrido-Bravo, Iris Paula, Díez-López, Carles, López-Granados, Amador, Manrique-Antón, Rebeca, Fernández-Pombo, Carmen Neri, Muñiz, Javier, and Crespo-Leiro, Maria Generosa
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- 2023
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4. Asistencia ventricular de larga duración en España (2007-2020). I informe del registro REGALAD
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Gómez-Bueno, Manuel, Pérez de la Sota, Enrique, Forteza Gil, Alberto, Ortiz-Berbel, Daniel, Castrodeza, Javier, García-Cosío Carmena, María Dolores, Barge-Caballero, Eduardo, Rangel Sousa, Diego, Díaz Molina, Beatriz, Manrique Antón, Rebeca, Almenar-Bonet, Luis, Uribarri González, Aitor, Barrio-Rodríguez, Alfredo, Castel Lavilla, María Ángeles, López-López, Laura, Dobarro Pérez, David, Pastor Pérez, Francisco, Burgos-Palacios, Virginia, Álvarez-García, Jesús, Garrido-Jiménez, José Manuel, González-Fernández, Óscar, Codina, Pau, López-Granados, Amador, Grau-Sepulveda, Andrés, and González-Costello, José
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- 2023
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5. Sex, Temporary Mechanical Circulatory Support, and Heart Transplantation
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Enríquez-Vázquez, Daniel, primary, Barge-Caballero, Eduardo, additional, González-Vílchez, Francisco, additional, Almenar-Bonet, Luis, additional, García-Cosío Carmena, María Dolores, additional, González-Costello, José, additional, Gómez-Bueno, Manuel, additional, Castel-Lavilla, María Ángeles, additional, Díaz-Molina, Beatriz, additional, Martínez-Sellés, Manuel, additional, Mirabet-Pérez, Sonia, additional, De la Fuente-Galán, Luis, additional, Hervás-Sotomayor, Daniela, additional, Rangel-Sousa, Diego, additional, Garrido-Bravo, Iris P., additional, Blasco-Peiró, Teresa, additional, Juan-Aracil, Gregorio Rábago, additional, Muñiz, Javier, additional, and Crespo-Leiro, María G., additional
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- 2023
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6. Prognostic Value of Serum Lactate Levels in Patients Undergoing Urgent Heart Transplant: A Subanalysis of the ASIS-TC Spanish Multicenter Study
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Couto-Mallón, David, González-Vílchez, Francisco, Almenar-Bonet, Luis, Díaz-Molina, Beatriz, Segovia-Cubero, Javier, González-Costello, José, Delgado-Jiménez, Juan, Castel-Lavilla, María A., Crespo-Leiro, María G., Rangel-Sousa, Diego, Martínez-Sellés, Manuel, Rábago-Juan-Aracil, Gregorio, De-la-Fuente-Galán, Luis, Blasco-Peiró, Teresa, Hervás-Sotomayor, Daniela, Garrido-Bravo, Iris P., Mirabet-Pérez, Sonia, Muñiz, Javier, and Barge-Caballero, Eduardo
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- 2019
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7. Use of a surgically implanted, nondischargeable, extracorporeal continuous flow circulatory support system as a bridge to heart transplant
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Villalba, Gonzalo Cabezón, primary, Caballero, Eduardo Barge, additional, Vílchez, Francisco González, additional, Castel-Lavilla, María Ángeles, additional, Bueno, Manuel Gómez, additional, Bonet, Luis Almenar, additional, Costello, José González, additional, Lambert-Rodríguez, José Luis, additional, Sellés, Manuel Martínez, additional, De La Fuente-Galán, Luis, additional, Pérez, Sonia Mirabet, additional, García-Cosío Carmena, María Dolores, additional, Sotomayor, Daniela Hervás, additional, Sousa, Diego Rangel, additional, Peiró, Teresa Blasco, additional, Garrido-Bravo, Iris P, additional, Juan-Aracil, Gregorio Rábago, additional, Muñiz, Javier, additional, and Crespo-Leiro, María G, additional
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- 2023
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8. Antifungal prophylaxis with nebulized amphotericin-B in solid-organ transplant recipients with severe COVID-19: a retrospective observational study
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Rombauts, Alexander, primary, Bodro, Marta, additional, Daniel Gumucio, Victor, additional, Carbonell, Irene, additional, Favà, Àlex, additional, Lladó, Laura, additional, González-Costello, José, additional, Oppenheimer, Federico, additional, Castel-Lavilla, María Ángeles, additional, Len, Oscar, additional, Marquez-Algaba, Ester, additional, Nuvials-Casals, Xavier, additional, Martínez González, Daniel, additional, Lacasa, Judith Sacanell, additional, Carratalà, Jordi, additional, and Sabé, Nuría, additional
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- 2023
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9. Temporal trends in the use and outcomes of temporary mechanical circulatory support as a bridge to cardiac transplantation in Spain. Final report of the ASIS-TC study
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Barge-Caballero, Eduardo, primary, González-Vílchez, Francisco, additional, Almenar-Bonet, Luis, additional, Carmena, María Dolores García-Cosío, additional, González-Costello, José, additional, Gómez-Bueno, Manuel, additional, Castel-Lavilla, María Ángeles, additional, Lambert-Rodríguez, José Luis, additional, Martínez-Sellés, Manuel, additional, Mirabet-Pérez, Sonia, additional, la Fuente-Galán, Luis De, additional, Hervás-Sotomayor, Daniela, additional, Rangel-Sousa, Diego, additional, Garrido-Bravo, Iris P., additional, Blasco-Peiró, Teresa, additional, Juan-Aracil, Gregorio Rábago, additional, Muñiz, Javier, additional, and Crespo-Leiro, María G., additional
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- 2023
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10. Incidence and prognosis of colorectal cancer after heart transplantation: data from the spanish post-heart transplant tumor registry
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Sagastagoitia-Fornie, Marta, Morán-Fernández, Laura, Blázquez-Bermejo, Zorba, Díaz-Molina, Beatriz, Gómez-Bueno, Manuel, Almenar-Bonet, Luis, López Granados, Amador, González-Vílchez, Francisco, Mirabet-Pérez, Sonia, García-Romero, Elena, Sobrino-Márquez, José Manuel, Rábago Juan-Aracil, Gregorio, Castel-Lavilla, María Ángeles, Blasco-Peiró, Teresa, Garrido-Bravo, Iris P., De la Fuente-Galán, Luis, Muñiz, Javier, Crespo-Leiro, María Generosa, Sagastagoitia-Fornie, Marta, Morán-Fernández, Laura, Blázquez-Bermejo, Zorba, Díaz-Molina, Beatriz, Gómez-Bueno, Manuel, Almenar-Bonet, Luis, López Granados, Amador, González-Vílchez, Francisco, Mirabet-Pérez, Sonia, García-Romero, Elena, Sobrino-Márquez, José Manuel, Rábago Juan-Aracil, Gregorio, Castel-Lavilla, María Ángeles, Blasco-Peiró, Teresa, Garrido-Bravo, Iris P., De la Fuente-Galán, Luis, Muñiz, Javier, and Crespo-Leiro, María Generosa
- Abstract
[Abstract] In this observational and multicenter study, that included all patients who underwent a heart transplantation (HT) in Spain from 1984 to 2018, we analyzed the incidence, management, and prognosis of colorectal cancer (CRC) after HT. Of 6,244 patients with a HT and a median follow-up of 8.8 years since the procedure, 116 CRC cases (11.5% of noncutaneous solid cancers other than lymphoma registered) were diagnosed, mainly adenocarcinomas, after a mean of 9.3 years post-HT. The incidence of CRC increased with age at HT from 56.6 per 100,000 person-years among under 45 year olds to 436.4 per 100,000 person-years among over 64 year olds. The incidence rates for age-at-diagnosis groups were significantly greater than those estimated for the general Spanish population. Curative surgery, performed for 62 of 74 operable tumors, increased the probability of patient survival since a diagnosis of CRC, from 31.6% to 75.7% at 2 years, and from 15.8% to 48.6% at 5 years, compared to patients with inoperable tumors. Our results suggest that the incidence of CRC among HT patients is greater than in the general population, increasing with age at HT.
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- 2023
11. Durable ventricular assist device in Spain (2007-2020). First report of the REGALAD registry
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Gómez-Bueno, Manuel, primary, Pérez de la Sota, Enrique, additional, Forteza Gil, Alberto, additional, Ortiz-Berbel, Daniel, additional, Castrodeza, Javier, additional, García-Cosío Carmena, María Dolores, additional, Barge-Caballero, Eduardo, additional, Rangel Sousa, Diego, additional, Díaz Molina, Beatriz, additional, Manrique Antón, Rebeca, additional, Almenar-Bonet, Luis, additional, Uribarri González, Aitor, additional, Barrio-Rodríguez, Alfredo, additional, Castel Lavilla, María Ángeles, additional, López-López, Laura, additional, Dobarro Pérez, David, additional, Pastor Pérez, Francisco, additional, Burgos-Palacios, Virginia, additional, Álvarez-García, Jesús, additional, Garrido-Jiménez, José Manuel, additional, González-Fernández, Óscar, additional, Codina, Pau, additional, López-Granados, Amador, additional, Grau-Sepulveda, Andrés, additional, and González-Costello, José, additional
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- 2022
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12. Asistencia ventricular de larga duración en España (2007-2020). I informe del registro REGALAD
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Gómez-Bueno, Manuel, primary, Pérez de la Sota, Enrique, additional, Forteza Gil, Alberto, additional, Ortiz-Berbel, Daniel, additional, Castrodeza, Javier, additional, García-Cosío Carmena, María Dolores, additional, Barge-Caballero, Eduardo, additional, Rangel Sousa, Diego, additional, Díaz Molina, Beatriz, additional, Manrique Antón, Rebeca, additional, Almenar-Bonet, Luis, additional, Uribarri González, Aitor, additional, Barrio-Rodríguez, Alfredo, additional, Castel Lavilla, María Ángeles, additional, López-López, Laura, additional, Dobarro Pérez, David, additional, Pastor Pérez, Francisco, additional, Burgos-Palacios, Virginia, additional, Álvarez-García, Jesús, additional, Garrido-Jiménez, José Manuel, additional, González-Fernández, Óscar, additional, Codina, Pau, additional, López-Granados, Amador, additional, Grau-Sepulveda, Andrés, additional, and González-Costello, José, additional
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- 2022
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13. Clinical outcomes of temporary mechanical circulatory support as a direct bridge to heart transplantation: a nationwide Spanish registry
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Barge‐Caballero, Eduardo, Almenar‐Bonet, Luis, Gonzalez‐Vilchez, Francisco, Lambert‐Rodríguez, José L., González‐Costello, José, Segovia‐Cubero, Javier, Castel‐Lavilla, María A., Delgado‐Jiménez, Juan, Garrido‐Bravo, Iris P., Rangel‐Sousa, Diego, Martínez‐Sellés, Manuel, De la Fuente‐Galan, Luis, Rábago‐Juan‐Aracil, Gregorio, Sanz‐Julve, Marisa, Hervás‐Sotomayor, Daniela, Mirabet‐Pérez, Sonia, Muñiz, Javier, and Crespo‐Leiro, Maria G.
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- 2018
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14. Durable ventricular assist device in Spain (2007-2020). First report of the REGALAD registry.
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Gómez-Bueno, Manuel, Pérez de la Sota, Enrique, Forteza Gil, Alberto, Ortiz-Berbel, Daniel, Castrodeza, Javier, García-Cosío Carmena, María Dolores, Barge-Caballero, Eduardo, Rangel Sousa, Diego, Díaz Molina, Beatriz, Manrique Antón, Rebeca, Almenar-Bonet, Luis, Uribarri González, Aitor, Barrio-Rodríguez, Alfredo, Castel Lavilla, María Ángeles, López-López, Laura, Dobarro Pérez, David, Pastor Pérez, Francisco, Burgos-Palacios, Virginia, Álvarez-García, Jesús, and Garrido-Jiménez, José Manuel
- Abstract
Copyright of Revista Española de Cardiología (18855857) is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2023
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15. Temporal trends in the use and outcomes of temporary mechanical circulatory support as a bridge to cardiac transplantation in Spain. Final report of the ASIS-TC study
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Barge-Caballero, Eduardo, González-Vílchez, Francisco, Almenar-Bonet, Luis, García-Cosío, María Dolores, González-Costello, José, Gómez-Bueno, Manuel, Castel-Lavilla, María Ángeles, Lambert-Rodríguez, José Luis, Martínez-Sellés, Manuel, Mirabet-Pérez, Sonia, De la Fuente-Galán, Luis, Hervás-Sotomayor, Daniela, Rangel-Sousa, Diego, Garrido-Bravo, Iris P., Blasco-Peiró, Teresa, Rábago Juan-Aracil, Gregorio, Muñiz, Javier, Crespo-Leiro, María Generosa, Barge-Caballero, Eduardo, González-Vílchez, Francisco, Almenar-Bonet, Luis, García-Cosío, María Dolores, González-Costello, José, Gómez-Bueno, Manuel, Castel-Lavilla, María Ángeles, Lambert-Rodríguez, José Luis, Martínez-Sellés, Manuel, Mirabet-Pérez, Sonia, De la Fuente-Galán, Luis, Hervás-Sotomayor, Daniela, Rangel-Sousa, Diego, Garrido-Bravo, Iris P., Blasco-Peiró, Teresa, Rábago Juan-Aracil, Gregorio, Muñiz, Javier, and Crespo-Leiro, María Generosa
- Abstract
[Abstract] Background: We aimed to describe recent trends in the use and outcomes of temporary mechanical circulatory support (MCS) as a bridge to heart transplantation (HTx) in Spain. Methods: Retrospective case-by-case analysis of 1,036 patients listed for emergency HTx while on temporary MCS in 16 Spanish institutions from January 1st, 2010 to December 31st, 2020. Patients were classified in 3 eras according to changes in donor allocation criteria (Era 1: January 2010/May 2014; Era 2: June 2014/May 2017; Era 3: June 2017/December 2020). Results: Over time, the proportion of candidates listed with intra-aortic balloon pumps decreased (Era 1 = 55.9%, Era 2 = 32%, Era 3 = 0.9%; p < 0.001), while the proportion of candidates listed with surgical continuous-flow temporary VADs (Era 1 = 10.6%, Era 2 = 32%, Era 3 = 49.1%; p < 0.001) and percutaneous VADs (Era 1 = 0.3%, Era 2 = 6.3%; Era 3 = 17.2%; p < 0.001) increased. Rates of HTx increased from Era 1 (79.4%) to Era 2 (87.8%), and Era 3 (87%) (p = 0.004), while rates of death before HTx decreased (Era 1 = 17.7%; Era 2 = 11%, Era 3 = 12.4%; p = 0.037) Median time from listing to HTx increased in patients supported with intra-aortic balloon pumps (Era 1 = 8 days, Era 2 = 15 days; p < 0.001) but remained stable in other candidates (Era 1 = 6 days; Era 2 = 5 days; Era 3 = 6 days; p = 0.134). One-year post-transplant survival was 71.4% in Era 1, 79.3% in Era 2, and 76.5% in Era 3 (p = 0.112). Preoperative bridging with ECMO was associated with increased 1-year post-transplant mortality (adjusted HR=1.71; 95% CI 1.15-2.53; p = 0.008). Conclusions: During the period 2010 to 2020, successive changes in the Spanish organ allocation protocol were followed by a significant increase of the rate of HTx and a significant reduction of waiting list mortality in candidates supported with temporary MCS. One-year post-transplant survival rates remained acceptable.
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- 2022
16. Venoarterial Extracorporeal Membrane Oxygenation with or without Simultaneous Intra-Aortic Balloon Pump Support as a Direct Bridge to Heart Transplantation: Results from a Nationwide Spanish Registry
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Barge-Caballero, Gonzalo, Castel-Lavilla, María A., Almenar-Bonet, Luis, Garrido-Bravo, Iris P., Delgado-Jiménez, Juan F., Rangel-Sousa, Diego, González-Costello, José, Segovia-Cubero, Javier, Farrero-Torres, Marta, Lambert Rodríguez, José Luis, Crespo-Leiro, María Generosa, Hervás-Sotomayor, Daniela, Portolés-Ocampo, Ana, Martínez-Sellés, Manuel, De la Fuente-Galán, Luis, Rábago, Gregorio, González-Vílchez, Francisco, Mirabet, Sonia, Muñiz, Javier, Barge-Caballero, Eduardo, Barge-Caballero, Gonzalo, Castel-Lavilla, María A., Almenar-Bonet, Luis, Garrido-Bravo, Iris P., Delgado-Jiménez, Juan F., Rangel-Sousa, Diego, González-Costello, José, Segovia-Cubero, Javier, Farrero-Torres, Marta, Lambert Rodríguez, José Luis, Crespo-Leiro, María Generosa, Hervás-Sotomayor, Daniela, Portolés-Ocampo, Ana, Martínez-Sellés, Manuel, De la Fuente-Galán, Luis, Rábago, Gregorio, González-Vílchez, Francisco, Mirabet, Sonia, Muñiz, Javier, and Barge-Caballero, Eduardo
- Abstract
[Abstract] OBJECTIVES To investigate the potential clinical benefit of an intra-aortic balloon pump (IABP) in patients supported with venoarterial extracorporeal membrane oxygenation (VA-ECMO) as a bridge to heart transplantation (HT). METHODS We studied 169 patients who were listed for urgent HT under VA-ECMO support at 16 Spanish institutions from 2010 to 2015. The clinical outcomes of patients under simultaneous IABP support (n = 73) were compared to a control group of patients without IABP support (n = 96). RESULTS There were no statistically significant differences between the IABP and control groups with regard to the cumulative rates of transplantation (71.2% vs 81.2%, P = 0.17), death during VA-ECMO support (20.6% vs 14.6%, P = 0.31), transition to a different mechanical circulatory support device (5.5% vs 5.2%, P = 0.94) or weaning from VA-ECMO support due to recovery (2.7% vs 0%, P = 0.10). There was a higher incidence of bleeding events in the IABP group (45.2% vs 25%, P = 0.006; adjusted odds ratio 2.18, 95% confidence interval 1.02–4.67). In-hospital postoperative mortality after HT was 34.6% in the IABP group and 32.5% in the control group (P = 0.80). One-year survival after listing for urgent HT was 53.3% in the IABP group and 52.2% in the control group (log rank P = 0.75). Multivariate adjustment for potential confounders did not change this result (adjusted hazard ratio 0.94, 95% confidence interval 0.56–1.58). CONCLUSIONS In our study, simultaneous IABP therapy in transplant candidates under VA-ECMO support did not significantly reduce morbidity or mortality.
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- 2019
17. Prognostic Value of Serum Lactate Levels in Patients Undergoing Urgent Heart Transplant: A Subanalysis of the ASIS-TC Spanish Multicenter Study
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Fundación Mutua Madrileña, Couto-Mallón, David, González-Vílchez, Francisco, Almenar-Bonet, Luis, Díaz-Molina, Beatriz, Segovia-Cubero, Javier, González-Costello, José, Delgado-Jiménez, Juan, Castel-Lavilla, María A., Crespo-Leiro, G., Rangel-Sousa, Diego, Martínez-Sellés, Manuel, Rábago-Juan-Aracil, Gregorio, De-la-Fuente-Galán, Luis, Blasco-Peiró, Teresa, Hervás-Sotomayor, Daniela, Garrido-Bravo, Iris P., Mirabet-Pérez, Sònia, Muñiz, Javier, Barge-Caballero, Eduardo, Fundación Mutua Madrileña, Couto-Mallón, David, González-Vílchez, Francisco, Almenar-Bonet, Luis, Díaz-Molina, Beatriz, Segovia-Cubero, Javier, González-Costello, José, Delgado-Jiménez, Juan, Castel-Lavilla, María A., Crespo-Leiro, G., Rangel-Sousa, Diego, Martínez-Sellés, Manuel, Rábago-Juan-Aracil, Gregorio, De-la-Fuente-Galán, Luis, Blasco-Peiró, Teresa, Hervás-Sotomayor, Daniela, Garrido-Bravo, Iris P., Mirabet-Pérez, Sònia, Muñiz, Javier, and Barge-Caballero, Eduardo
- Abstract
[EN] Introduction and objectives: To study the prognostic value of serum lactate in patients under temporary preoperative mechanical circulatory support who underwent urgent heart transplant. Methods: We conducted a subanalysis of a Spanish multicenter registry recording data on patients under temporary mechanical circulatory support listed for highly urgent heart transplant from 2010 to 2015. Participants selected for the present study were those who received a transplant and who had known preoperative serum lactate levels. The main study outcome was 1-year survival after transplant. Results: A total of 177 heart transplant recipients were studied; preoperatively, 90 were supported on venoarterial extracorporeal membrane oxygenation, 51 on temporary left ventricular assist devices, and 36 on temporary biventricular assist devices. Preoperative hyperlactatemia (≥ 2 mmol/L) was present in 44 (25%) patients. On multivariable analysis, pretransplant serum lactate was identified as an independent predictor of 1-year posttransplant survival (adjusted HR per 0.1 mmol/L, 1.02; 95%CI, 1.01-1.03; P = .007). One-year posttransplant survival was 53.1% (95%CI, 45.3-60.9) in patients with preoperative hyperlactatemia and 75.6% (95%CI, 71.8-79.4) in those without preoperative hyperlactatemia (adjusted HR, 1.94; 95%CI, 1.04-3.63; P = .039). Preoperative hyperlactatemia correlated with adverse outcomes in patients supported with extracorporeal membrane oxygenation, but not in patients supported on ventricular assist devices. Conclusions: Preoperative serum lactate is a strong independent predictor of worse outcomes in patients undergoing urgent heart transplant on short-term mechanical circulatory support., [ES] Introducción y objetivos: Analizar el impacto del lactato sérico en receptores de trasplante cardiaco urgente en asistencia circulatoria mecánica de corta duración preoperatoria. Métodos: Se realizó un subanálisis de un registro multicéntrico español basado en pacientes incluidos en «urgencia grado 0» para trasplante cardiaco con asistencia circulatoria mecánica preoperatoria de corta duración entre 2010 y 2015. Se seleccionó a los receptores de trasplante con cifras preoperatorias de lactato conocidas. El desenlace principal fue la supervivencia 1 año tras el trasplante. Resultados: Se estudió a 177 receptores de trasplante cardiaco urgente, de los que 90 necesitaron asistencia preoperatoria con oxigenador extracorpóreo de membrana venoarterial, 51 con asistencia ventricular izquierda y 36 con asistencia biventricular. De ellos, 44 (25%) presentaban hiperlactatemia antes del trasplante (≥ 2 mmol/l). En el análisis multivariable, la cifra de lactato sérico resultó predictora independiente de mortalidad tras el trasplante (cada 0,1 mmol/l, HR ajustada = 1,02; IC95%, 1,01-1,03; p = 0,007). La supervivencia estimada al año del trasplante cardiaco fue del 53,1% (IC95%, 45,3-60,9) en los pacientes con hiperlactactemia preoperatoria y el 75,6% (IC95%, 71,8-79,4) en los pacientes sin hiperlactatemia (HR ajustada = 1,94; IC95%, 1,04-3,63; p = 0,039). El impacto pronóstico de la hiperlactatemia fue significativo en los pacientes asistidos con oxigenador extracorpóreo de membrana venoarterial, pero no en aquellos con dispositivos de asistencia ventricular. Conclusiones: Los valores preoperatorios de ácido láctico son un potente factor pronóstico independiente en receptores de trasplante cardiaco urgente.
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- 2019
18. Clinical outcomes of temporary mechanical circulatory support as a direct bridge to heart transplantation: a nationwide Spanish registry
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Barge Caballero, Eduardo, Almenar Bonet, Luis, González-Vílchez, Francisco, Lambert Rodríguez, José Luis, González Costello, José, Segovia Cubero, Javier, Castel Lavilla, María A., Delgado Jiménez, Juan, Martínez Sellés Oliveria Soares, Manuel, and Crespo Leiro, María G.
- Subjects
Trasplante de órganos ,surgical procedures, operative ,Enfermedad cardiovascular ,Cardiología - Abstract
Background: In Spain, listing for high-urgent heart transplantation is allowed for critically ill candidates not weanable from temporary mechanical circulatory support (T-MCS). We sought to analyse the clinical outcomes of this strategy. Methods and results: We conducted a case-by-case, retrospective review of clinical records of 291 adult patients listed for high-urgent heart transplantation under temporary devices from 2010 to 2015 in 16 Spanish institutions. Survival after listing and adverse clinical events were studied. At the time of listing, 169 (58%) patients were supported on veno-arterial extracorporeal membrane oxygenation (VA-ECMO), 70 (24%) on temporary left ventricular assist devices (T-LVAD) and 52 (18%) on temporary biventricular assist devices (T-BiVAD). Seven patients transitioned from VA-ECMO to temporary ventricular assist devices while on the waiting list. Mean time on T-MCS was 13.1 ± 12.6 days. Mean time from listing to transplantation was 7.6 ± 8.5 days. Overall, 230 (79%) patients were transplanted and 54 (18.6%) died during MCS. In-hospital postoperative mortality after transplantation was 33.3%, 11.9% and 26.2% for patients bridged on VA-ECMO, T-LVAD and T-BiVAD, respectively (P = 0.008). Overall survival from listing to hospital discharge was 54.4%, 78.6% and 55.8%, respectively (P = 0.002). T-LVAD support was independently associated with a lower risk of death over the first year after listing (hazard ratio 0.52, 95% confidence interval 0.30–0.92). Patients treated with VA-ECMO showed the highest incidence rate of adverse clinical events associated with T-MCS. Conclusion: Temporary devices may be used to bridge critically ill candidates directly to heart transplantation in a setting of short waiting list times, as is the case of Spain. In our series, bridging with T-LVAD was associated with more favourable outcomes than bridging with T-BiVAD or VA-ECMO. Sin financiación 12.129 JCR (2018) Q1, 6/136 Cardiac & Cardiovascular Systems 5.537 SJR (2018) Q1, 6/365 Cardiology and Cardiovascular Medicine No data IDR 2018 UEM
- Published
- 2018
19. Venoarterial extracorporeal membrane oxygenation with or without simultaneous intra-aortic balloon pump support as a direct bridge to heart transplantation: results from a nationwide Spanish registry
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Barge-Caballero, Gonzalo, primary, Castel-Lavilla, María A, additional, Almenar-Bonet, Luis, additional, Garrido-Bravo, Iris P, additional, Delgado, Juan F, additional, Rangel-Sousa, Diego, additional, González-Costello, José, additional, Segovia-Cubero, Javier, additional, Farrero-Torres, Marta, additional, Lambert-Rodríguez, José Luis, additional, Crespo-Leiro, María G, additional, Hervás-Sotomayor, Daniela, additional, Portolés-Ocampo, Ana, additional, Martínez-Sellés, Manuel, additional, De la Fuente-Galán, Luis, additional, Rábago-Juan-Aracil, Gregorio, additional, González-Vílchez, Francisco, additional, Mirabet-Pérez, Sonia, additional, Muñiz, Javier, additional, and Barge-Caballero, Eduardo, additional
- Published
- 2019
- Full Text
- View/download PDF
20. Valor pronóstico de la concentración sérica de lactato de los receptores de trasplante cardiaco urgente: subanálisis del estudio multicéntrico español ASIS-TC
- Author
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Couto-Mallón, David, primary, González-Vílchez, Francisco, additional, Almenar-Bonet, Luis, additional, Díaz-Molina, Beatriz, additional, Segovia-Cubero, Javier, additional, González-Costello, José, additional, Delgado-Jiménez, Juan, additional, Castel-Lavilla, María A., additional, Crespo-Leiro, María G., additional, Rangel-Sousa, Diego, additional, Martínez-Sellés, Manuel, additional, Rábago-Juan-Aracil, Gregorio, additional, De-la-Fuente-Galán, Luis, additional, Blasco-Peiró, Teresa, additional, Hervás-Sotomayor, Daniela, additional, Garrido-Bravo, Iris P., additional, Mirabet-Pérez, Sonia, additional, Muñiz, Javier, additional, and Barge-Caballero, Eduardo, additional
- Published
- 2019
- Full Text
- View/download PDF
21. Prognostic value of serum lactate levels in patients undergoing urgent heart transplant: a subanalysis of the ASIS-TC spanish multicenter study
- Author
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Couto-Mallón, David, González-Vílchez, Francisco, Almenar-Bonet, Luis, Díaz-Molina, Beatriz, Segovia-Cubero, Javier, González-Costello, José, Delgado-Jiménez, Juan F., Castel-Lavilla, María A., Crespo-Leiro, María Generosa, Rangel-Sousa, Diego, Martínez-Sellés, Manuel, Rábago, Gregorio, De-la-Fuente Galán, Luis, Blasco-Peiró, Teresa, Hervás-Sotomayor, Daniela, Garrido-Bravo, Iris P., Mirabet, Sonia, Muñiz, Javier, Barge-Caballero, Eduardo, Couto-Mallón, David, González-Vílchez, Francisco, Almenar-Bonet, Luis, Díaz-Molina, Beatriz, Segovia-Cubero, Javier, González-Costello, José, Delgado-Jiménez, Juan F., Castel-Lavilla, María A., Crespo-Leiro, María Generosa, Rangel-Sousa, Diego, Martínez-Sellés, Manuel, Rábago, Gregorio, De-la-Fuente Galán, Luis, Blasco-Peiró, Teresa, Hervás-Sotomayor, Daniela, Garrido-Bravo, Iris P., Mirabet, Sonia, Muñiz, Javier, and Barge-Caballero, Eduardo
- Abstract
[Abstract] Introduction and objectives. To study the prognostic value of serum lactate in patients under temporary preoperative mechanical circulatory support who underwent urgent heart transplant. Methods. We conducted a subanalysis of a Spanish multicenter registry recording data on patients under temporary mechanical circulatory support listed for highly urgent heart transplant from 2010 to 2015. Participants selected for the present study were those who received a transplant and who had known preoperative serum lactate levels. The main study outcome was 1-year survival after transplant. Results. A total of 177 heart transplant recipients were studied; preoperatively, 90 were supported on venoarterial extracorporeal membrane oxygenation, 51 on temporary left ventricular assist devices, and 36 on temporary biventricular assist devices. Preoperative hyperlactatemia (≥ 2 mmol/L) was present in 44 (25%) patients. On multivariable analysis, pretransplant serum lactate was identified as an independent predictor of 1-year posttransplant survival (adjusted HR per 0.1 mmol/L, 1.02; 95%CI, 1.01-1.03; P = .007). One-year posttransplant survival was 53.1% (95%CI, 45.3-60.9) in patients with preoperative hyperlactatemia and 75.6% (95%CI, 71.8-79.4) in those without preoperative hyperlactatemia (adjusted HR, 1.94; 95%CI, 1.04-3.63; P = .039). Preoperative hyperlactatemia correlated with adverse outcomes in patients supported with extracorporeal membrane oxygenation, but not in patients supported on ventricular assist devices. Conclusions. Preoperative serum lactate is a strong independent predictor of worse outcomes in patients undergoing urgent heart transplant on short-term mechanical circulatory support., [Resumen] Introducción y objetivos. Analizar el impacto del lactato sérico en receptores de trasplante cardiaco urgente en asistencia circulatoria mecánica de corta duración preoperatoria. Métodos. Se realizó un subanálisis de un registro multicéntrico español basado en pacientes incluidos en «urgencia grado 0» para trasplante cardiaco con asistencia circulatoria mecánica preoperatoria de corta duración entre 2010 y 2015. Se seleccionó a los receptores de trasplante con cifras preoperatorias de lactato conocidas. El desenlace principal fue la supervivencia 1 año tras el trasplante. Resultados. Se estudió a 177 receptores de trasplante cardiaco urgente, de los que 90 necesitaron asistencia preoperatoria con oxigenador extracorpóreo de membrana venoarterial, 51 con asistencia ventricular izquierda y 36 con asistencia biventricular. De ellos, 44 (25%) presentaban hiperlactatemia antes del trasplante (≥ 2 mmol/l). En el análisis multivariable, la cifra de lactato sérico resultó predictora independiente de mortalidad tras el trasplante (cada 0,1 mmol/l, HR ajustada = 1,02; IC95%, 1,01-1,03; p = 0,007). La supervivencia estimada al año del trasplante cardiaco fue del 53,1% (IC95%, 45,3-60,9) en los pacientes con hiperlactactemia preoperatoria y el 75,6% (IC95%, 71,8-79,4) en los pacientes sin hiperlactatemia (HR ajustada = 1,94; IC95%, 1,04-3,63; p = 0,039). El impacto pronóstico de la hiperlactatemia fue significativo en los pacientes asistidos con oxigenador extracorpóreo de membrana venoarterial, pero no en aquellos con dispositivos de asistencia ventricular. Conclusiones. Los valores preoperatorios de ácido láctico son un potente factor pronóstico independiente en receptores de trasplante cardiaco urgente.
- Published
- 2018
22. Clinical outcomes of temporary mechanical circulatory support as a direct bridge to heart transplantation: a nationwide Spanish registry
- Author
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Barge-Caballero, Eduardo, primary, Almenar-Bonet, Luis, additional, Gonzalez-Vilchez, Francisco, additional, Lambert-Rodríguez, José L., additional, González-Costello, José, additional, Segovia-Cubero, Javier, additional, Castel-Lavilla, María A., additional, Delgado-Jiménez, Juan, additional, Garrido-Bravo, Iris P., additional, Rangel-Sousa, Diego, additional, Martínez-Sellés, Manuel, additional, De la Fuente-Galan, Luis, additional, Rábago-Juan-Aracil, Gregorio, additional, Sanz-Julve, Marisa, additional, Hervás-Sotomayor, Daniela, additional, Mirabet-Pérez, Sonia, additional, Muñiz, Javier, additional, and Crespo-Leiro, Maria G., additional
- Published
- 2017
- Full Text
- View/download PDF
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