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5. The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group

Author

El Bairi, Khalid, Haynes, Harry R, Blackley, Elizabeth, Fineberg, Susan, Shear, Jeffrey, Turner, Sophia, de Freitas, Juliana Ribeiro, Sur, Daniel, Amendola, Luis Claudio, Gharib, Masoumeh, Kallala, Amine, Arun, Indu, Azmoudeh-Ardalan, Farid, Fujimoto, Luciana, Sua, Luz F, Liu, Shi-Wei, Lien, Huang-Chun, Kirtani, Pawan, Balancin, Marcelo, El Attar, Hicham, Guleria, Prerna, Yang, Wenxian, Shash, Emad, Chen, I-Chun, Bautista, Veronica, Do Prado Moura, Jose Fernando, Rapoport, Bernardo L, Castaneda, Carlos, Spengler, Eunice, Acosta-Haab, Gabriela, Frahm, Isabel, Sanchez, Joselyn, Castillo, Miluska, Bouchmaa, Najat, Md Zin, Reena R, Shui, Ruohong, Onyuma, Timothy, Yang, Wentao, Husain, Zaheed, Willard-Gallo, Karen, Coosemans, An, Perez, Edith A, Provenzano, Elena, Ericsson, Paula Gonzalez, Richardet, Eduardo, Mehrotra, Ravi, Sarancone, Sandra, Ehinger, Anna, Rimm, David L, Bartlett, John MS, Viale, Giuseppe, Denkert, Carsten, Hida, Akira I, Sotiriou, Christos, Loibl, Sibylle, Hewitt, Stephen M, Badve, Sunil, Symmans, William Fraser, Kim, Rim S, Pruneri, Giancarlo, Goel, Shom, Francis, Prudence A, Inurrigarro, Gloria, Yamaguchi, Rin, Garcia-Rivello, Hernan, Horlings, Hugo, Afqir, Said, Salgado, Roberto, Adams, Sylvia, Kok, Marleen, Dieci, Maria Vittoria, Michiels, Stefan, Demaria, Sandra, and Loi, Sherene

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Breast Cancer, Cancer, Clinical Research, 4.1 Discovery and preclinical testing of markers and technologies, Detection, screening and diagnosis, Good Health and Well Being, International Immuno-Oncology Biomarker Working Group, Clinical sciences, Oncology and carcinogenesis, Epidemiology
Abstract

The advent of immune-checkpoint inhibitors (ICI) in modern oncology has significantly improved survival in several cancer settings. A subgroup of women with breast cancer (BC) has immunogenic infiltration of lymphocytes with expression of programmed death-ligand 1 (PD-L1). These patients may potentially benefit from ICI targeting the programmed death 1 (PD-1)/PD-L1 signaling axis. The use of tumor-infiltrating lymphocytes (TILs) as predictive and prognostic biomarkers has been under intense examination. Emerging data suggest that TILs are associated with response to both cytotoxic treatments and immunotherapy, particularly for patients with triple-negative BC. In this review from The International Immuno-Oncology Biomarker Working Group, we discuss (a) the biological understanding of TILs, (b) their analytical and clinical validity and efforts toward the clinical utility in BC, and (c) the current status of PD-L1 and TIL testing across different continents, including experiences from low-to-middle-income countries, incorporating also the view of a patient advocate. This information will help set the stage for future approaches to optimize the understanding and clinical utilization of TIL analysis in patients with BC.

Published
2021

11. Solving the Heat Transfer Equation by a Finite Difference Method Using Multi-dimensional Arrays in CUDA as in Standard C

Author

Sanchez-Noguez, Josefina, Couder-Castañeda, Carlos, Hernández-Gómez, J. J., Navarro-Reyes, Itzel, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Prates, Raquel Oliveira, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Gitler, Isidoro, editor, Barrios Hernández, Carlos Jaime, editor, and Meneses, Esteban, editor

Published
2022
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12. Calculation of the Probability of Landslides Caused by Precipitation Applying the Janbu and MonteCarlo Method in Skarn-Type Mineral Deposits

Author

Castañeda, Carlos, Dibucho, Koseth, Arauzo, Luis, Raymundo, Carlos, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Ahram, Tareq, editor, and Taiar, Redha, editor

Published
2022
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16. Breast cancer subtype and survival among Indigenous American women in Peru

Author

Tamayo, Lizeth I, Vidaurre, Tatiana, Vásquez, Jeannie Navarro, Casavilca, Sandro, Palomino, Jessica I Aramburu, Calderon, Monica, Abugattas, Julio E, Gomez, Henry L, Castaneda, Carlos A, Song, Sikai, Cherry, Daniel, Rauscher, Garth H, and Fejerman, Laura

Subjects
Biomedical and Clinical Sciences, Health Sciences, Oncology and Carcinogenesis, Prevention, Cancer, Breast Cancer, Good Health and Well Being, Adult, Aged, Disease-Free Survival, Female, Humans, Incidence, Middle Aged, Peru, Survival Rate, Triple Negative Breast Neoplasms, General Science & Technology
Abstract

Latina women in the U.S. have relatively low breast cancer incidence compared to Non-Latina White (NLW) or African American women but are more likely to be diagnosed with the more aggressive "triple negative" breast cancer (TNBC). Latinos in the U.S. are a heterogeneous group originating from different countries with different cultural and ancestral backgrounds. Little is known about the distribution of tumor subtypes in Latin American regions. Clinical records of 303 female Peruvian patients, from the Peruvian National Cancer Institute, were analyzed. Participants were diagnosed with invasive breast cancer between 2010 and 2015 and were identified as residing in either the Selva or Sierra region. We used Fisher's exact test for proportions and multivariable Cox Proportional Hazards Models to compare overall survival between regions. Women from the Selva region were more likely to be diagnosed with TNBC than women from the Sierra region (31% vs. 14%, p = 0.01). In the unadjusted Cox model, the hazard of mortality was 1.7 times higher in women from the Selva than the Sierra (p = 0.025); this survival difference appeared to be largely explained by differences in the prevalence of TNBC. Our results suggest that the distribution of breast cancer subtypes differs between highly Indigenous American women from two regions of Peru. Disentangling the factors that contribute to this difference will add valuable information to better target prevention and treatment efforts in Peru and improve our understanding of TNBC among all women. This study demonstrates the need for larger datasets of Latin American patients to address differences between Latino subpopulations and optimize targeted prevention and treatment.

Published
2018

20. Preferential Radar Method for Dynamic Assignment of Wi-Fi Channels

Author

Sandoval Posso, Jesús David, Giraldo Castañeda, Carlos Andres, Akan, Ozgur, Editorial Board Member, Bellavista, Paolo, Editorial Board Member, Cao, Jiannong, Editorial Board Member, Coulson, Geoffrey, Editorial Board Member, Dressler, Falko, Editorial Board Member, Ferrari, Domenico, Editorial Board Member, Gerla, Mario, Editorial Board Member, Kobayashi, Hisashi, Editorial Board Member, Palazzo, Sergio, Editorial Board Member, Sahni, Sartaj, Editorial Board Member, Shen, Xuemin (Sherman), Editorial Board Member, Stan, Mircea, Editorial Board Member, Xiaohua, Jia, Editorial Board Member, Zomaya, Albert Y., Editorial Board Member, Kliks, Adrian, editor, Kryszkiewicz, Paweł, editor, Bader, Faouzi, editor, Triantafyllopoulou, Dionysia, editor, Caicedo, Carlos E., editor, Sezgin, Aydin, editor, Dimitriou, Nikos, editor, and Sybis, Michał, editor

Published
2019
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21. Pattern Recognition Through Empirical Mode Decomposition for Temperature Time Series Between 1986 and 2019 in Mexico City Downtown for Global Warming Assessment

Author

Orozco-del-Castillo, Mauricio Gabriel, Hernández-Gómez, Jorge J., Yañez-Casas, Gabriela Aurora, Moreno-Sabido, Mario Renán, Couder-Castañeda, Carlos, Medina, Isaac, Novelo-Cruz, Raúl, Enciso-Aguilar, Mauro Alberto, Barbosa, Simone Diniz Junqueira, Editorial Board Member, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Kotenko, Igor, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Mata-Rivera, Miguel Felix, editor, Zagal-Flores, Roberto, editor, and Barría-Huidobro, Cristian, editor

Published
2019
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24. Neoadjuvant letrozole plus taselisib versus letrozole plus placebo in postmenopausal women with oestrogen receptor-positive, HER2-negative, early-stage breast cancer (LORELEI): a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial

Author

Saura, Cristina, Hlauschek, Dominik, Oliveira, Mafalda, Zardavas, Dimitrios, Jallitsch-Halper, Anita, de la Peña, Lorena, Nuciforo, Paolo, Ballestrero, Alberto, Dubsky, Peter, Lombard, Janine M, Vuylsteke, Peter, Castaneda, Carlos A, Colleoni, Marco, Santos Borges, Giuliano, Ciruelos, Eva, Fornier, Monica, Boer, Katalin, Bardia, Aditya, Wilson, Timothy R, Stout, Thomas J, Hsu, Jerry Y, Shi, Yi, Piccart, Martine, Gnant, Michael, Baselga, José, and de Azambuja, Evandro

Published
2019
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30. Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer

Author

Kos, Zuzana, Roblin, Elvire, Kim, Rim S., Michiels, Stefan, Gallas, Brandon D., Chen, Weijie, van de Vijver, Koen K., Goel, Shom, Adams, Sylvia, Demaria, Sandra, Viale, Giuseppe, Nielsen, Torsten O., Badve, Sunil S., Symmans, W. Fraser, Sotiriou, Christos, Rimm, David L., Hewitt, Stephen, Denkert, Carsten, Loibl, Sibylle, Luen, Stephen J., Bartlett, John M. S., Savas, Peter, Pruneri, Giancarlo, Dillon, Deborah A., Cheang, Maggie Chon U., Tutt, Andrew, Hall, Jacqueline A., Kok, Marleen, Horlings, Hugo M., Madabhushi, Anant, van der Laak, Jeroen, Ciompi, Francesco, Laenkholm, Anne-Vibeke, Bellolio, Enrique, Gruosso, Tina, Fox, Stephen B., Araya, Juan Carlos, Floris, Giuseppe, Hudeček, Jan, Voorwerk, Leonie, Beck, Andrew H., Kerner, Jen, Larsimont, Denis, Declercq, Sabine, Van den Eynden, Gert, Pusztai, Lajos, Ehinger, Anna, Yang, Wentao, AbdulJabbar, Khalid, Yuan, Yinyin, Singh, Rajendra, Hiley, Crispin, Bakir, Maise al, Lazar, Alexander J., Naber, Stephen, Wienert, Stephan, Castillo, Miluska, Curigliano, Giuseppe, Dieci, Maria-Vittoria, André, Fabrice, Swanton, Charles, Reis-Filho, Jorge, Sparano, Joseph, Balslev, Eva, Chen, I-Chun, Stovgaard, Elisabeth Ida Specht, Pogue-Geile, Katherine, Blenman, Kim R. M., Penault-Llorca, Frédérique, Schnitt, Stuart, Lakhani, Sunil R., Vincent-Salomon, Anne, Rojo, Federico, Braybrooke, Jeremy P., Hanna, Matthew G., Soler-Monsó, M. Teresa, Bethmann, Daniel, Castaneda, Carlos A., Willard-Gallo, Karen, Sharma, Ashish, Lien, Huang-Chun, Fineberg, Susan, Thagaard, Jeppe, Comerma, Laura, Gonzalez-Ericsson, Paula, Brogi, Edi, Loi, Sherene, Saltz, Joel, Klaushen, Frederick, Cooper, Lee, Amgad, Mohamed, Moore, David A., and Salgado, Roberto

Published
2020
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33. Aproximaciones a la salud desde la complejidad, la ética y la medicina

Author

Castañeda, Carlos Eduardo Maldonado, Comp., Chico, Wilson Andrés Parra, Tobler, Chantal Aristizábal, Villamizar, Santiago Galvis, López, Ana Camila García, Rodríguez, María Carolina Martínez, Castañeda, Carlos Eduardo Maldonado, Chico, Wilson Andrés Parra, Tobler, Chantal Aristizábal, Villamizar, Santiago Galvis, López, Ana Camila García, and Rodríguez, María Carolina Martínez

Published
2022
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35. Abstract 6623: Spatial organization of tumor-infiltrating lymphocytes (TILs) is prognostic for survival in triple negative breast cancer (TNBC)

Author

Patel, Sahil H., primary, Corredor, Germán, additional, Yoder, Rachel, additional, Barrera, Cristian, additional, Castillo, Miluska, additional, Bernabe, Luis, additional, Staley, Joshua, additional, Stecklein, Shane, additional, Viswanath, Satish E., additional, Castaneda, Carlos A., additional, Sharma, Priyanka, additional, and Madabhushi, Anant, additional

Published
2023
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36. Supplementary Table S7 from Combined Label-Free Quantitative Proteomics and microRNA Expression Analysis of Breast Cancer Unravel Molecular Differences with Clinical Implications

Author

Gámez-Pozo, Angelo, primary, Berges-Soria, Julia, primary, Arevalillo, Jorge M., primary, Nanni, Paolo, primary, López-Vacas, Rocío, primary, Navarro, Hilario, primary, Grossmann, Jonas, primary, Castaneda, Carlos A., primary, Main, Paloma, primary, Díaz-Almirón, Mariana, primary, Espinosa, Enrique, primary, Ciruelos, Eva, primary, and Fresno Vara, Juan Ángel, primary

Published
2023
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37. Data from Combined Label-Free Quantitative Proteomics and microRNA Expression Analysis of Breast Cancer Unravel Molecular Differences with Clinical Implications

Author

Gámez-Pozo, Angelo, primary, Berges-Soria, Julia, primary, Arevalillo, Jorge M., primary, Nanni, Paolo, primary, López-Vacas, Rocío, primary, Navarro, Hilario, primary, Grossmann, Jonas, primary, Castaneda, Carlos A., primary, Main, Paloma, primary, Díaz-Almirón, Mariana, primary, Espinosa, Enrique, primary, Ciruelos, Eva, primary, and Fresno Vara, Juan Ángel, primary

Published
2023
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38. Supplementary Figure S2 from Combined Label-Free Quantitative Proteomics and microRNA Expression Analysis of Breast Cancer Unravel Molecular Differences with Clinical Implications

Author

Gámez-Pozo, Angelo, primary, Berges-Soria, Julia, primary, Arevalillo, Jorge M., primary, Nanni, Paolo, primary, López-Vacas, Rocío, primary, Navarro, Hilario, primary, Grossmann, Jonas, primary, Castaneda, Carlos A., primary, Main, Paloma, primary, Díaz-Almirón, Mariana, primary, Espinosa, Enrique, primary, Ciruelos, Eva, primary, and Fresno Vara, Juan Ángel, primary

Published
2023
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39. Supplementary Table and Figure Legend from Combined Label-Free Quantitative Proteomics and microRNA Expression Analysis of Breast Cancer Unravel Molecular Differences with Clinical Implications

Author

Gámez-Pozo, Angelo, primary, Berges-Soria, Julia, primary, Arevalillo, Jorge M., primary, Nanni, Paolo, primary, López-Vacas, Rocío, primary, Navarro, Hilario, primary, Grossmann, Jonas, primary, Castaneda, Carlos A., primary, Main, Paloma, primary, Díaz-Almirón, Mariana, primary, Espinosa, Enrique, primary, Ciruelos, Eva, primary, and Fresno Vara, Juan Ángel, primary

Published
2023
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45. Evaluation of a Telepresence Robot for the Elderly: A Spanish Experience

Author

Gonzalez-Jimenez, Javier, Galindo, Cipriano, Gutierrez-Castaneda, Carlos, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Ferrández Vicente, José Manuel, editor, Álvarez Sánchez, José Ramón, editor, de la Paz López, Félix, editor, and Toledo Moreo, Fco. Javier, editor

Published
2013
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48. Nutraceuticals: A Promising Therapeutic Approach in Ophthalmology

Author

Castro-Castaneda, Carlos Rodrigo, primary, Altamirano-Lamarque, Francisco, additional, Ortega-Macías, Alan Gabriel, additional, Santa Cruz-Pavlovich, Francisco J., additional, Gonzalez-De la Rosa, Alejandro, additional, Armendariz-Borunda, Juan, additional, Santos, Arturo, additional, and Navarro-Partida, Jose, additional

Published
2022
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49. Association between PIK3CA Mutations in Blood and Tumor-Infiltrating Lymphocytes in Peruvian Breast Cancer Patients

Author

Castaneda, Carlos, primary, Castillo, Miluska, additional, Bernabe, Luis, additional, Suarez, Nancy, additional, Romero, Atocha, additional, Sanchez, Joselyn, additional, Torres, Ebert, additional, Enciso, Javier, additional, Tello, Katherine, additional, Enciso, Nataly, additional, Velarde, Marco, additional, De La Cruz, Miguel, additional, Dunstan, Jorge, additional, Cotrina, Jose, additional, Abugattas, Julio, additional, Pinillos, Miguel, additional, Roque, Katia, additional, Fuentes, Hugo, additional, Poquioma, Ebert, additional, Guerra, Henry, additional, and Gomez, Henry, additional

Published
2022
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