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2. Circulating miR-26b-5p and miR-451a as diagnostic biomarkers in medullary thyroid carcinoma patients

Author

Besharat, Z. M., Trocchianesi, S., Verrienti, A., Ciampi, R., Cantara, S., Romei, C., Sabato, C., Noviello, T. M. R., Po, A., Citarella, A., Caruso, F. P., Panariello, I., Gianno, F., Carpino, G., Gaudio, E., Chiacchiarini, M., Masuelli, L., Sponziello, M., Pecce, V., Ramone, T., Maino, F., Dotta, F., Ceccarelli, M., Pezzullo, L., Durante, C., Castagna, M. G., Elisei, R., and Ferretti, E.

Published
2023
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3. Correction: Circulating miR‑26b‑5p and miR‑451a as diagnostic biomarkers in medullary thyroid carcinoma patients

Author

Besharat, Z. M., Trocchianesi, S., Verrienti, A., Ciampi, R., Cantara, S., Romei, C., Sabato, C., Noviello, T. M. R., Po, A., Citarella, A., Caruso, F. P., Panariello, I., Gianno, F., Carpino, G., Gaudio, E., Chiacchiarini, M., Masuelli, L., Sponziello, M., Pecce, V., Ramone, T., Maino, F., Dotta, F., Ceccarelli, M., Pezzullo, L., Durante, C., Castagna, M. G., Elisei, R., and Ferretti, E.

Published
2024
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13. Features and outcome of differentiated thyroid carcinoma associated with Graves’ disease: results of a large, retrospective, multicenter study

Author

Premoli, P., Tanda, M. L., Piantanida, E., Veronesi, G., Gallo, D., Masiello, E., Rosetti, S., Cusini, C., Boi, F., Bulla, J., Rodia, R., Mariotti, S., Capelli, V., Rotondi, M., Magri, F., Chiovato, L., Rocchi, R., Campopiano, M. C., Elisei, R., Vitti, P., Barbato, F., Pilli, T., Castagna, M. G., Pacini, F., and Bartalena, L.

Published
2020
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15. DataBrain: a web-accessible database for three-dimensional reconstructions and quantitative morphometrics of neurons

Author

Magliaro, C., Callara, A. L., Arami, N., De Maria, C., Ferrari, V., Vanello, N., Tognetti, A., Mangione, M., Viaggi, M. C., Vaglini, F., Castagna, M., De Rossi, D., Landini, L., Ahluwalia, A., Magjarevic, Ratko, Editor-in-chief, Ładyżyński, Piotr, Series editor, Ibrahim, Fatimah, Series editor, Lacković, Igor, Series editor, Rock, Emilio Sacristan, Series editor, Eskola, Hannu, editor, Väisänen, Outi, editor, Viik, Jari, editor, and Hyttinen, Jari, editor

Published
2018
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19. Correction: Circulating miR‑26b‑5p and miR‑451a as diagnostic biomarkers in medullary thyroid carcinoma patients

Author

Besharat, Z. M., primary, Trocchianesi, S., additional, Verrienti, A., additional, Ciampi, R., additional, Cantara, S., additional, Romei, C., additional, Sabato, C., additional, Noviello, T. M. R., additional, Po, A., additional, Citarella, A., additional, Caruso, F. P., additional, Panariello, I., additional, Gianno, F., additional, Carpino, G., additional, Gaudio, E., additional, Chiacchiarini, M., additional, Masuelli, L., additional, Sponziello, M., additional, Pecce, V., additional, Ramone, T., additional, Maino, F., additional, Dotta, F., additional, Ceccarelli, M., additional, Pezzullo, L., additional, Durante, C., additional, Castagna, M. G., additional, Elisei, R., additional, and Ferretti, E., additional

Published
2023
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23. Drought Conditions Enhance Groundwater Table Fluctuations Caused by Hydropower Plant Management

Author

Basilio Hazas, M., Marcolini, G., Castagna, M., Galli, M., Singh, T., Wohlmuth, B., Chiogna, G., 1 School of Engineering and Design Technical University of Munich Munich Germany, and 2 Department of Numerical Mathematics Technical University of Munich Garching Germany

Subjects
GENERAL, Climate and interannual variability, Numerical modeling, Time series experiments, NATURAL HAZARDS, Atmospheric, Geological, Oceanic, Physical modeling, Climate impact, Risk, Disaster risk analysis and assessment, Preparedness and planning, NONLINEAR GEOPHYSICS, Probability distributions, heavy and fat-tailed, Scaling: spatial and temporal, OCEANOGRAPHY: PHYSICAL, Air/sea interactions, Decadal ocean variability, Ocean influence of Earth rotation, Sea level: variations and mean, Surface waves and tides, Tsunamis and storm surges, PALEOCEANOGRAPHY, POLICY SCIENCES, Benefit-cost analysis, Regional planning, RADIO SCIENCE, Radio oceanography, SEISMOLOGY, Earthquake ground motions and engineering seismology, Volcano seismology, SPACE PLASMA PHYSICS, Stochastic phenomena, VOLCANOLOGY, Volcano/climate interactions, Atmospheric effects, Volcano monitoring, Effusive volcanism, Mud volcanism, Explosive volcanism, Volcanic hazards and risks, Research Article, surface water-groundwater interaction, hydropower, managed rivers, groundwater modeling [ATMOSPHERIC COMPOSITION AND STRUCTURE, Air/sea constituent fluxes, Volcanic effects, BIOGEOSCIENCES, Climate dynamics, Modeling, COMPUTATIONAL GEOPHYSICS, Numerical solutions, CRYOSPHERE, Avalanches, Mass balance, GEODESY AND GRAVITY, Ocean monitoring with geodetic techniques, Ocean/Earth/atmosphere/hydrosphere/cryosphere interactions, Global change from geodesy, GLOBAL CHANGE, Abrupt/rapid climate change, Climate variability, Earth system modeling, Impacts of global change, Land/atmosphere interactions, Oceans, Regional climate change, Sea level change, Solid Earth, Water cycles, HYDROLOGY, Groundwater hydrology, Groundwater/surface water interaction, Time series analysis, Water management, Climate impacts, Extreme events, Hydrological cycles and budgets, INFORMATICS, Temporal analysis and representation, MARINE GEOLOGY AND GEOPHYSICS, Gravity and isostasy, MATHEMATICAL GEOPHYSICS, Persistence, memory, correlations, clustering, Stochastic processes, ATMOSPHERIC PROCESSES, Climate change and variability, Climatology, General circulation, Ocean/atmosphere interactions, Regional modeling, Theoretical modeling, OCEANOGRAPHY], groundwater modeling, ddc:551, surface water‐groundwater interaction, ddc, Water Science and Technology
Abstract

Management of hydropower plants strongly influences streamflow dynamics and hence the interaction between surface water and groundwater. As dam operations cause variations in river stages, these can result in changes in the groundwater level at multiple temporal scales. In this work, we study the case of an Alpine aquifer, where weekly fluctuations are particularly pronounced. We consider an area with four river reaches differently impacted by reservoir operations and investigate the influence of these rivers on the common aquifer. Using continuous wavelet transform and wavelet coherence analysis, we show that weekly fluctuations in the groundwater table are particularly pronounced in dry years, in particular in the winter season, although the area of the aquifer impacted by dam operations remains almost unchanged. We thus observe that in Alpine catchments, surface water‐groundwater interaction is sensitive to the conditions determined by a specific hydrological year. We also investigate the influences of the river‐aquifer water fluxes and show that under dry conditions hydropeaking mainly affects their temporal dynamics. Our observations have significant consequences for predicting nutrient and temperature dynamics/regimes in river‐aquifer systems impacted by hydropower plant management., Plain Language Summary: The operation of hydropower plants affects the water level in the downstream part of the river, which in turn can alter the groundwater level. In this work, we study an Alpine aquifer crossed by rivers differently impacted by hydropower production. We use statistical tools to analyze the interaction between the rivers and the groundwater, and observe that this interaction is sensitive to the conditions of the hydrological year, such as dry periods., Key Points: Wavelet power spectrum and coherence analysis is used to study river‐aquifer interactions under dam operations in an Alpine catchment. The impact of reservoir operations on the aquifer is strongest under low flow conditions but the area impacted shows little variation. Under low flow conditions, dam operations considerably influence the frequency of the water exchange between rivers and aquifer., Consejo Nacional de Ciencia y Tecnología http://dx.doi.org/10.13039/501100003141, Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659, Consejo Veracruzano de Investigación Científica y Desarrollo Tecnológico, https://doi.org/10.17632/97jchhz4s8.2

Published
2022

24. Shorter androgen receptor polyQ alleles protect against life-threatening COVID-19 disease in European males

Author

Baldassarri, M, Picchiotti, N, Fava, F, Fallerini, C, Benetti, E, Daga, S, Valentino, F, Doddato, G, Furini, S, Giliberti, A, Tita, R, Amitrano, S, Bruttini, M, Croci, S, Meloni, I, Pinto, A, Iuso, N, Gabbi, C, Sciarra, F, Venneri, M, Gori, M, Sanarico, M, Crawley, F, Pagotto, U, Fanelli, F, Mezzullo, M, Dominguez-Garrido, E, Planas-Serra, L, Schluter, A, Colobran, R, Soler-Palacin, P, Lapunzina, P, Tenorio, J, Pujol, A, Castagna, M, Marcelli, M, Isidori, A, Renieri, A, Frullanti, E, Mari, F, Montagnani, F, Di Sarno, L, Tommasi, A, Palmieri, M, Fabbiani, M, Rossetti, B, Zanelli, G, Sestini, F, Bergantini, L, D'Alessandro, M, Cameli, P, Bennett, D, Anedda, F, Marcantonio, S, Scolletta, S, Franchi, F, Mazzei, M, Guerrini, S, Conticini, E, Cantarini, L, Frediani, B, Tacconi, D, Spertilli, C, Feri, M, Donati, A, Scala, R, Guidelli, L, Spargi, G, Corridi, M, Nencioni, C, Croci, L, Caldarelli, G, Spagnesi, M, Piacentini, P, Bandini, M, Desanctis, E, Cappelli, S, Canaccini, A, Verzuri, A, Anemoli, V, Ognibene, A, Vaghi, M, Monforte, A, Merlini, E, Miraglia, F, Mondelli, M, Mantovani, S, Ludovisi, S, Girardis, M, Venturelli, S, Sita, M, Cossarizza, A, Antinori, A, Vergori, A, Emiliozzi, A, Rusconi, S, Siano, M, Gabrieli, A, Riva, A, Francisci, D, Schiaroli, E, Paciosi, F, Scotton, P, Andretta, F, Panese, S, Baratti, S, Scaggiante, R, Gatti, F, Parisi, S, Castelli, F, Quiros-Roldan, E, Antoni, M, Zanella, I, Monica, M, Piscopo, C, Capasso, M, Russo, R, Andolfo, I, Iolascon, A, Fiorentino, G, Carella, M, Castori, M, Merla, G, Aucella, F, Raggi, P, Marciano, C, Perna, R, Bassetti, M, Di Biagio, A, Sanguinetti, M, Masucci, L, Valente, S, Mencarelli, M, Lo Rizzo, C, Bargagli, E, Mandala, M, Giorli, A, Salerni, L, Zucchi, P, Parravicini, P, Menatti, E, Trotta, T, Giannattasio, F, Coiro, G, Lena, F, Coviello, D, Mussini, C, Bosio, G, Martinelli, E, Mancarella, S, Tavecchia, L, Crotti, L, Parati, G, Aguilera-Albesa, S, Albu, S, Casasnovas, C, Velez-Santamaria, V, Horcajada, J, Villar, J, Rodriguez-Palmero, A, Ruiz, M, Seijo, L, Troya, J, Valencia-Ramos, J, Gut, M, Baldassarri M., Picchiotti N., Fava F., Fallerini C., Benetti E., Daga S., Valentino F., Doddato G., Furini S., Giliberti A., Tita R., Amitrano S., Bruttini M., Croci S., Meloni I., Pinto A. M., Iuso N., Gabbi C., Sciarra F., Venneri M. A., Gori M., Sanarico M., Crawley F. P., Pagotto U., Fanelli F., Mezzullo M., Dominguez-Garrido E., Planas-Serra L., Schluter A., Colobran R., Soler-Palacin P., Lapunzina P., Tenorio J., Pujol A., Castagna M. G., Marcelli M., Isidori A. M., Renieri A., Frullanti E., Mari F., Montagnani F., Di Sarno L., Tommasi A., Palmieri M., Fabbiani M., Rossetti B., Zanelli G., Sestini F., Bergantini L., D'Alessandro M., Cameli P., Bennett D., Anedda F., Marcantonio S., Scolletta S., Franchi F., Mazzei M. A., Guerrini S., Conticini E., Cantarini L., Frediani B., Tacconi D., Spertilli C., Feri M., Donati A., Scala R., Guidelli L., Spargi G., Corridi M., Nencioni C., Croci L., Caldarelli G. P., Spagnesi M., Piacentini P., Bandini M., Desanctis E., Cappelli S., Canaccini A., Verzuri A., Anemoli V., Ognibene A., Vaghi M., Monforte A. D., Merlini E., Miraglia F. G., Mondelli M. U., Mantovani S., Ludovisi S., Girardis M., Venturelli S., Sita M., Cossarizza A., Antinori A., Vergori A., Emiliozzi A., Rusconi S., Siano M., Gabrieli A., Riva A., Francisci D., Schiaroli E., Paciosi F., Scotton P. G., Andretta F., Panese S., Baratti S., Scaggiante R., Gatti F., Parisi S. G., Castelli F., Quiros-Roldan E., Antoni M. D., Zanella I., Monica M. D., Piscopo C., Capasso M., Russo R., Andolfo I., Iolascon A., Fiorentino G., Carella M., Castori M., Merla G., Aucella F., Raggi P., Marciano C., Perna R., Bassetti M., Di Biagio A., Sanguinetti M., Masucci L., Valente S., Mencarelli M. A., Lo Rizzo C., Bargagli E., Mandala M., Giorli A., Salerni L., Zucchi P., Parravicini P., Menatti E., Trotta T., Giannattasio F., Coiro G., Lena F., Coviello D. A., Mussini C., Bosio G., Martinelli E., Mancarella S., Tavecchia L., Crotti L., Parati G., Aguilera-Albesa S., Albu S., Casasnovas C., Velez-Santamaria V., Horcajada J. P., Villar J., Rodriguez-Palmero A., Ruiz M., Seijo L. M., Troya J., Valencia-Ramos J., Gut M., Baldassarri, M, Picchiotti, N, Fava, F, Fallerini, C, Benetti, E, Daga, S, Valentino, F, Doddato, G, Furini, S, Giliberti, A, Tita, R, Amitrano, S, Bruttini, M, Croci, S, Meloni, I, Pinto, A, Iuso, N, Gabbi, C, Sciarra, F, Venneri, M, Gori, M, Sanarico, M, Crawley, F, Pagotto, U, Fanelli, F, Mezzullo, M, Dominguez-Garrido, E, Planas-Serra, L, Schluter, A, Colobran, R, Soler-Palacin, P, Lapunzina, P, Tenorio, J, Pujol, A, Castagna, M, Marcelli, M, Isidori, A, Renieri, A, Frullanti, E, Mari, F, Montagnani, F, Di Sarno, L, Tommasi, A, Palmieri, M, Fabbiani, M, Rossetti, B, Zanelli, G, Sestini, F, Bergantini, L, D'Alessandro, M, Cameli, P, Bennett, D, Anedda, F, Marcantonio, S, Scolletta, S, Franchi, F, Mazzei, M, Guerrini, S, Conticini, E, Cantarini, L, Frediani, B, Tacconi, D, Spertilli, C, Feri, M, Donati, A, Scala, R, Guidelli, L, Spargi, G, Corridi, M, Nencioni, C, Croci, L, Caldarelli, G, Spagnesi, M, Piacentini, P, Bandini, M, Desanctis, E, Cappelli, S, Canaccini, A, Verzuri, A, Anemoli, V, Ognibene, A, Vaghi, M, Monforte, A, Merlini, E, Miraglia, F, Mondelli, M, Mantovani, S, Ludovisi, S, Girardis, M, Venturelli, S, Sita, M, Cossarizza, A, Antinori, A, Vergori, A, Emiliozzi, A, Rusconi, S, Siano, M, Gabrieli, A, Riva, A, Francisci, D, Schiaroli, E, Paciosi, F, Scotton, P, Andretta, F, Panese, S, Baratti, S, Scaggiante, R, Gatti, F, Parisi, S, Castelli, F, Quiros-Roldan, E, Antoni, M, Zanella, I, Monica, M, Piscopo, C, Capasso, M, Russo, R, Andolfo, I, Iolascon, A, Fiorentino, G, Carella, M, Castori, M, Merla, G, Aucella, F, Raggi, P, Marciano, C, Perna, R, Bassetti, M, Di Biagio, A, Sanguinetti, M, Masucci, L, Valente, S, Mencarelli, M, Lo Rizzo, C, Bargagli, E, Mandala, M, Giorli, A, Salerni, L, Zucchi, P, Parravicini, P, Menatti, E, Trotta, T, Giannattasio, F, Coiro, G, Lena, F, Coviello, D, Mussini, C, Bosio, G, Martinelli, E, Mancarella, S, Tavecchia, L, Crotti, L, Parati, G, Aguilera-Albesa, S, Albu, S, Casasnovas, C, Velez-Santamaria, V, Horcajada, J, Villar, J, Rodriguez-Palmero, A, Ruiz, M, Seijo, L, Troya, J, Valencia-Ramos, J, Gut, M, Baldassarri M., Picchiotti N., Fava F., Fallerini C., Benetti E., Daga S., Valentino F., Doddato G., Furini S., Giliberti A., Tita R., Amitrano S., Bruttini M., Croci S., Meloni I., Pinto A. M., Iuso N., Gabbi C., Sciarra F., Venneri M. A., Gori M., Sanarico M., Crawley F. P., Pagotto U., Fanelli F., Mezzullo M., Dominguez-Garrido E., Planas-Serra L., Schluter A., Colobran R., Soler-Palacin P., Lapunzina P., Tenorio J., Pujol A., Castagna M. G., Marcelli M., Isidori A. M., Renieri A., Frullanti E., Mari F., Montagnani F., Di Sarno L., Tommasi A., Palmieri M., Fabbiani M., Rossetti B., Zanelli G., Sestini F., Bergantini L., D'Alessandro M., Cameli P., Bennett D., Anedda F., Marcantonio S., Scolletta S., Franchi F., Mazzei M. A., Guerrini S., Conticini E., Cantarini L., Frediani B., Tacconi D., Spertilli C., Feri M., Donati A., Scala R., Guidelli L., Spargi G., Corridi M., Nencioni C., Croci L., Caldarelli G. P., Spagnesi M., Piacentini P., Bandini M., Desanctis E., Cappelli S., Canaccini A., Verzuri A., Anemoli V., Ognibene A., Vaghi M., Monforte A. D., Merlini E., Miraglia F. G., Mondelli M. U., Mantovani S., Ludovisi S., Girardis M., Venturelli S., Sita M., Cossarizza A., Antinori A., Vergori A., Emiliozzi A., Rusconi S., Siano M., Gabrieli A., Riva A., Francisci D., Schiaroli E., Paciosi F., Scotton P. G., Andretta F., Panese S., Baratti S., Scaggiante R., Gatti F., Parisi S. G., Castelli F., Quiros-Roldan E., Antoni M. D., Zanella I., Monica M. D., Piscopo C., Capasso M., Russo R., Andolfo I., Iolascon A., Fiorentino G., Carella M., Castori M., Merla G., Aucella F., Raggi P., Marciano C., Perna R., Bassetti M., Di Biagio A., Sanguinetti M., Masucci L., Valente S., Mencarelli M. A., Lo Rizzo C., Bargagli E., Mandala M., Giorli A., Salerni L., Zucchi P., Parravicini P., Menatti E., Trotta T., Giannattasio F., Coiro G., Lena F., Coviello D. A., Mussini C., Bosio G., Martinelli E., Mancarella S., Tavecchia L., Crotti L., Parati G., Aguilera-Albesa S., Albu S., Casasnovas C., Velez-Santamaria V., Horcajada J. P., Villar J., Rodriguez-Palmero A., Ruiz M., Seijo L. M., Troya J., Valencia-Ramos J., and Gut M.

Abstract

Background: While SARS-CoV-2 similarly infects men and women, COVID-19 outcome is less favorable in men. Variability in COVID-19 severity may be explained by differences in the host genome. Methods: We compared poly-amino acids variability from WES data in severely affected COVID-19 patients versus SARS-CoV-2 PCR-positive oligo-asymptomatic subjects. Findings: Shorter polyQ alleles (≤22) in the androgen receptor (AR) conferred protection against severe outcome in COVID-19 in the first tested cohort (both males and females) of 638 Italian subjects. The association between long polyQ alleles (≥23) and severe clinical outcome (p = 0.024) was also validated in an independent cohort of Spanish men <60 years of age (p = 0.014). Testosterone was higher in subjects with AR long-polyQ, possibly indicating receptor resistance (p = 0.042 Mann-Whitney U test). Inappropriately low serum testosterone level among carriers of the long-polyQ alleles (p = 0.0004 Mann-Whitney U test) predicted the need for intensive care in COVID-19 infected men. In agreement with the known anti-inflammatory action of testosterone, patients with long-polyQ and age ≥60 years had increased levels of CRP (p = 0.018, not accounting for multiple testing). Interpretation: We identify the first genetic polymorphism that appears to predispose some men to develop more severe disease. Failure of the endocrine feedback to overcome AR signaling defects by increasing testosterone levels during the infection leads to the polyQ tract becoming dominant to serum testosterone levels for the clinical outcome. These results may contribute to designing reliable clinical and public health measures and provide a rationale to test testosterone as adjuvant therapy in men with COVID-19 expressing long AR polyQ repeats. Funding: MIUR project “Dipartimenti di Eccellenza 2018-2020” to Department of Medical Biotechnologies University of Siena, Italy (Italian D.L. n.18 March 17, 2020) and “Bando Ricerca COVID-19 Toscana” project

Published
2021

25. DataBrain: a web-accessible database for three-dimensional reconstructions and quantitative morphometrics of neurons

Author

Magliaro, C., primary, Callara, A. L., additional, Arami, N., additional, De Maria, C., additional, Ferrari, V., additional, Vanello, N., additional, Tognetti, A., additional, Mangione, M., additional, Viaggi, M. C., additional, Vaglini, F., additional, Castagna, M., additional, De Rossi, D., additional, Landini, L., additional, and Ahluwalia, A., additional

Published
2017
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26. Recombinant Human Thyrotropin-Stimulated Serum Thyroglobulin Combined with Neck Ultrasonography Has the Highest Sensitivity in Monitoring Differentiated Thyroid Carcinoma.

Author

PACINI, F., MOLINARO, E., CASTAGNA, M. G., AGATE, L., ELISEI, R., CECCARELLI, C., LIPPI, F., TADDEI, D., GRASSO, L., and PINCHERA, A.

Abstract

Recombinant human TSH (rhTSH)-stimulated thyroglobulin (Tg) measurement and 131I whole body scan (WBS) have been validated as informative tests in the postsurgical follow-up of differentiated thyroid carcinoma. We report the diagnostic accuracy of Tg measurement and diagnostic WBS, alone or in combination, after rhTSH stimulation in a retrospective, consecutive series of patients undergoing follow-up for differentiated thyroid cancer. Routine procedures also include neck ultrasound in every patient and post-therapy WBS when indicated. We studied 340 consecutive patients with differentiated thyroid carcinoma, previously treated with near-total thyroidectomy and 131I thyroid ablation, scheduled for routine diagnostic tests. At baseline on L-T4-suppressive therapy, 294 patients had undetectable (<1 ng/ml) serum Tg and negative anti-Tg autoantibodies (TgAb), 25 patients had undetectable serum Tg and positive TgAb, and 21 patients had detectable serum Tg and negative TgAb. These patients were tested for the presence of active disease byrhTSHstimulation. The results of our study showed that rhTSH-stimulated Tg alone had a diagnostic sensitivity of 85% for detecting active disease and a negative predictive value (NPV) of 98.2%. After adding the results of neck ultrasound, sensitivity increased to 96.3%, and the NPV to 99.5%. rhTSH-stimulated WBS had a sensitivity of only 21% and a NPV of 89%. The combination of rhTSH-stimulated Tg and WBS had a sensitivity of 92.7% and a NPV of 99%. We conclude that the rhTSH-stimulated Tg test combined with neck ultrasonography has the highest diagnostic accuracy in detecting persistent disease in the follow-up of differentiated thyroid carcinoma. A detectable level of serum Tg on L-T4, its conversion from undetectable to detectable after rhTSH, and/or a suspicious finding at ultrasound will allow the identification of patients requiring therapeutic procedures without the need for diagnostic WBS. [ABSTRACT FROM AUTHOR]

Published
2023
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28. Shorter androgen receptor polyQ alleles protect against life-threatening COVID-19 disease in European males

Author

Baldassarri M., Picchiotti N., Fava F., Fallerini C., Benetti E., Daga S., Valentino F., Doddato G., Furini S., Giliberti A., Tita R., Amitrano S., Bruttini M., Croci S., Meloni I., Pinto A. M., Iuso N., Gabbi C., Sciarra F., Venneri M. A., Gori M., Sanarico M., Crawley F. P., Pagotto U., Fanelli F., Mezzullo M., Dominguez-Garrido E., Planas-Serra L., Schluter A., Colobran R., Soler-Palacin P., Lapunzina P., Tenorio J., Pujol A., Castagna M. G., Marcelli M., Isidori A. M., Renieri A., Frullanti E., Mari F., Montagnani F., Di Sarno L., Tommasi A., Palmieri M., Fabbiani M., Rossetti B., Zanelli G., Sestini F., Bergantini L., D'Alessandro M., Cameli P., Bennett D., Anedda F., Marcantonio S., Scolletta S., Franchi F., Mazzei M. A., Guerrini S., Conticini E., Cantarini L., Frediani B., Tacconi D., Spertilli C., Feri M., Donati A., Scala R., Guidelli L., Spargi G., Corridi M., Nencioni C., Croci L., Caldarelli G. P., Spagnesi M., Piacentini P., Bandini M., Desanctis E., Cappelli S., Canaccini A., Verzuri A., Anemoli V., Ognibene A., Vaghi M., Monforte A. D., Merlini E., Miraglia F. G., Mondelli M. U., Mantovani S., Ludovisi S., Girardis M., Venturelli S., Sita M., Cossarizza A., Antinori A., Vergori A., Emiliozzi A., Rusconi S., Siano M., Gabrieli A., Riva A., Francisci D., Schiaroli E., Paciosi F., Scotton P. G., Andretta F., Panese S., Baratti S., Scaggiante R., Gatti F., Parisi S. G., Castelli F., Quiros-Roldan E., Antoni M. D., Zanella I., Monica M. D., Piscopo C., Capasso M., Russo R., Andolfo I., Iolascon A., Fiorentino G., Carella M., Castori M., Merla G., Aucella F., Raggi P., Marciano C., Perna R., Bassetti M., Di Biagio A., Sanguinetti M., Masucci L., Valente S., Mencarelli M. A., Lo Rizzo C., Bargagli E., Mandala M., Giorli A., Salerni L., Zucchi P., Parravicini P., Menatti E., Trotta T., Giannattasio F., Coiro G., Lena F., Coviello D. A., Mussini C., Bosio G., Martinelli E., Mancarella S., Tavecchia L., Crotti L., Parati G., Aguilera-Albesa S., Albu S., Casasnovas C., Velez-Santamaria V., Horcajada J. P., Villar J., Rodriguez-Palmero A., Ruiz M., Seijo L. M., Troya J., Valencia-Ramos J., Gut M., Institut Català de la Salut, [Baldassarri M, Fallerini C] Medical Genetics, University of Siena, Italy. Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Italy. [Picchiotti N] University of Siena, DIISM-SAILAB, Siena, Italy. Department of Mathematics, University of Pavia, Pavia, Italy. [Fava F] Medical Genetics, University of Siena, Italy. Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Italy. Genetica Medica, Azienda Ospedaliero-Universitaria Senese, Italy. [Benetti E] Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Italy. [Colobran R] Servei d’Immunologia, Àrea de Genètica, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Soler-Palacin P] Unitat de Patologia Infecciosa i Immunodeficiències de Pediatria, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus, Baldassarri M., Picchiotti N., Fava F., Fallerini C., Benetti E., Daga S., Valentino F., Doddato G., Furini S., Giliberti A., Tita R., Amitrano S., Bruttini M., Croci S., Meloni I., Pinto A.M., Iuso N., Gabbi C., Sciarra F., Venneri M.A., Gori M., Sanarico M., Crawley F.P., Pagotto U., Fanelli F., Mezzullo M., Dominguez-Garrido E., Planas-Serra L., Schluter A., Colobran R., Soler-Palacin P., Lapunzina P., Tenorio J., Pujol A., Castagna M.G., Marcelli M., Isidori A.M., Renieri A., Frullanti E., Mari F., Montagnani F., Di Sarno L., Tommasi A., Palmieri M., Fabbiani M., Rossetti B., Zanelli G., Sestini F., Bergantini L., D'Alessandro M., Cameli P., Bennett D., Anedda F., Marcantonio S., Scolletta S., Franchi F., Mazzei M.A., Guerrini S., Conticini E., Cantarini L., Frediani B., Tacconi D., Spertilli C., Feri M., Donati A., Scala R., Guidelli L., Spargi G., Corridi M., Nencioni C., Croci L., Caldarelli G.P., Spagnesi M., Piacentini P., Bandini M., Desanctis E., Cappelli S., Canaccini A., Verzuri A., Anemoli V., Ognibene A., Vaghi M., Monforte A.D., Merlini E., Miraglia F.G., Mondelli M.U., Mantovani S., Ludovisi S., Girardis M., Venturelli S., Sita M., Cossarizza A., Antinori A., Vergori A., Emiliozzi A., Rusconi S., Siano M., Gabrieli A., Riva A., Francisci D., Schiaroli E., Paciosi F., Scotton P.G., Andretta F., Panese S., Baratti S., Scaggiante R., Gatti F., Parisi S.G., Castelli F., Quiros-Roldan E., Antoni M.D., Zanella I., Monica M.D., Piscopo C., Capasso M., Russo R., Andolfo I., Iolascon A., Fiorentino G., Carella M., Castori M., Merla G., Aucella F., Raggi P., Marciano C., Perna R., Bassetti M., Di Biagio A., Sanguinetti M., Masucci L., Valente S., Mencarelli M.A., Lo Rizzo C., Bargagli E., Mandala M., Giorli A., Salerni L., Zucchi P., Parravicini P., Menatti E., Trotta T., Giannattasio F., Coiro G., Lena F., Coviello D.A., Mussini C., Bosio G., Martinelli E., Mancarella S., Tavecchia L., Crotti L., Parati G., Aguilera-Albesa S., Albu S., Casasnovas C., Velez-Santamaria V., Horcajada J.P., Villar J., Rodriguez-Palmero A., Ruiz M., Seijo L.M., Troya J., Valencia-Ramos J., Gut M., Baldassarri, M., Picchiotti, N., Fava, F., Fallerini, C., Benetti, E., Daga, S., Valentino, F., Doddato, G., Furini, S., Giliberti, A., Tita, R., Amitrano, S., Bruttini, M., Croci, S., Meloni, I., Pinto, A. M., Iuso, N., Gabbi, C., Sciarra, F., Venneri, M. A., Gori, M., Sanarico, M., Crawley, F. P., Pagotto, U., Fanelli, F., Mezzullo, M., Dominguez-Garrido, E., Planas-Serra, L., Schluter, A., Colobran, R., Soler-Palacin, P., Lapunzina, P., Tenorio, J., Pujol, A., Castagna, M. G., Marcelli, M., Isidori, A. M., Renieri, A., Frullanti, E., Mari, F., Montagnani, F., Di Sarno, L., Tommasi, A., Palmieri, M., Fabbiani, M., Rossetti, B., Zanelli, G., Sestini, F., Bergantini, L., D'Alessandro, M., Cameli, P., Bennett, D., Anedda, F., Marcantonio, S., Scolletta, S., Franchi, F., Mazzei, M. A., Guerrini, S., Conticini, E., Cantarini, L., Frediani, B., Tacconi, D., Spertilli, C., Feri, M., Donati, A., Scala, R., Guidelli, L., Spargi, G., Corridi, M., Nencioni, C., Croci, L., Caldarelli, G. P., Spagnesi, M., Piacentini, P., Bandini, M., Desanctis, E., Cappelli, S., Canaccini, A., Verzuri, A., Anemoli, V., Ognibene, A., Vaghi, M., Monforte, A. D., Merlini, E., Miraglia, F. G., Mondelli, M. U., Mantovani, S., Ludovisi, S., Girardis, M., Venturelli, S., Sita, M., Cossarizza, A., Antinori, A., Vergori, A., Emiliozzi, A., Rusconi, S., Siano, M., Gabrieli, A., Riva, A., Francisci, D., Schiaroli, E., Paciosi, F., Scotton, P. G., Andretta, F., Panese, S., Baratti, S., Scaggiante, R., Gatti, F., Parisi, S. G., Castelli, F., Quiros-Roldan, E., Antoni, M. D., Zanella, I., Monica, M. D., Piscopo, C., Capasso, M., Russo, R., Andolfo, I., Iolascon, A., Fiorentino, G., Carella, M., Castori, M., Merla, G., Aucella, F., Raggi, P., Marciano, C., Perna, R., Bassetti, M., Di Biagio, A., Sanguinetti, M., Masucci, L., Valente, S., Mencarelli, M. A., Lo Rizzo, C., Bargagli, E., Mandala, M., Giorli, A., Salerni, L., Zucchi, P., Parravicini, P., Menatti, E., Trotta, T., Giannattasio, F., Coiro, G., Lena, F., Coviello, D. A., Mussini, C., Bosio, G., Martinelli, E., Mancarella, S., Tavecchia, L., Crotti, L., Parati, G., Aguilera-Albesa, S., Albu, S., Casasnovas, C., Velez-Santamaria, V., Horcajada, J. P., Villar, J., Rodriguez-Palmero, A., Ruiz, M., Seijo, L. M., Troya, J., Valencia-Ramos, J., Gut, M., Baldassarri, M, Picchiotti, N, Fava, F, Fallerini, C, Benetti, E, Daga, S, Valentino, F, Doddato, G, Furini, S, Giliberti, A, Tita, R, Amitrano, S, Bruttini, M, Croci, S, Meloni, I, Pinto, A, Iuso, N, Gabbi, C, Sciarra, F, Venneri, M, Gori, M, Sanarico, M, Crawley, F, Pagotto, U, Fanelli, F, Mezzullo, M, Dominguez-Garrido, E, Planas-Serra, L, Schluter, A, Colobran, R, Soler-Palacin, P, Lapunzina, P, Tenorio, J, Pujol, A, Castagna, M, Marcelli, M, Isidori, A, Renieri, A, Frullanti, E, Mari, F, Montagnani, F, Di Sarno, L, Tommasi, A, Palmieri, M, Fabbiani, M, Rossetti, B, Zanelli, G, Sestini, F, Bergantini, L, D'Alessandro, M, Cameli, P, Bennett, D, Anedda, F, Marcantonio, S, Scolletta, S, Franchi, F, Mazzei, M, Guerrini, S, Conticini, E, Cantarini, L, Frediani, B, Tacconi, D, Spertilli, C, Feri, M, Donati, A, Scala, R, Guidelli, L, Spargi, G, Corridi, M, Nencioni, C, Croci, L, Caldarelli, G, Spagnesi, M, Piacentini, P, Bandini, M, Desanctis, E, Cappelli, S, Canaccini, A, Verzuri, A, Anemoli, V, Ognibene, A, Vaghi, M, Monforte, A, Merlini, E, Miraglia, F, Mondelli, M, Mantovani, S, Ludovisi, S, Girardis, M, Venturelli, S, Sita, M, Cossarizza, A, Antinori, A, Vergori, A, Emiliozzi, A, Rusconi, S, Siano, M, Gabrieli, A, Riva, A, Francisci, D, Schiaroli, E, Paciosi, F, Scotton, P, Andretta, F, Panese, S, Baratti, S, Scaggiante, R, Gatti, F, Parisi, S, Castelli, F, Quiros-Roldan, E, Antoni, M, Zanella, I, Monica, M, Piscopo, C, Capasso, M, Russo, R, Andolfo, I, Iolascon, A, Fiorentino, G, Carella, M, Castori, M, Merla, G, Aucella, F, Raggi, P, Marciano, C, Perna, R, Bassetti, M, Di Biagio, A, Sanguinetti, M, Masucci, L, Valente, S, Mencarelli, M, Lo Rizzo, C, Bargagli, E, Mandala, M, Giorli, A, Salerni, L, Zucchi, P, Parravicini, P, Menatti, E, Trotta, T, Giannattasio, F, Coiro, G, Lena, F, Coviello, D, Mussini, C, Bosio, G, Martinelli, E, Mancarella, S, Tavecchia, L, Crotti, L, Parati, G, Aguilera-Albesa, S, Albu, S, Casasnovas, C, Velez-Santamaria, V, Horcajada, J, Villar, J, Rodriguez-Palmero, A, Ruiz, M, Seijo, L, Troya, J, Valencia-Ramos, J, and Gut, M

Subjects
0301 basic medicine, Oncology, Male, lcsh:Medicine, Disease, COVID-19 (Malaltia), Severity of Illness Index, Androgen, Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Gonadal Hormones::Gonadal Steroid Hormones::Testosterone Congeners::Testosterone [CHEMICALS AND DRUGS], 0302 clinical medicine, Risk Factors, Receptors, virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES], Testosterone, Other subheadings::/therapeutic use [Other subheadings], Amino Acids, Peptides, and Proteins::Proteins::Receptors, Cytoplasmic and Nuclear::Receptors, Steroid::Receptors, Androgen [CHEMICALS AND DRUGS], Testosterona, Androgen receptor gene, COVID-19, LASSO logistic regression, Viral infection and host genome, WES, Aged, Case-Control Studies, Critical Care, Female, Genome, Human, Humans, Middle Aged, Peptides, Polymorphism, Single Nucleotide, Receptors, Androgen, SARS-CoV-2, Spain, lcsh:R5-920, Genome, Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES], General Medicine, Single Nucleotide, Testosterona - Ús terapèutic, Homes -- Malalties, androgen receptor gene, testosterone, viral infection and host genome, 030220 oncology & carcinogenesis, Cohort, Peptide, aminoácidos, péptidos y proteínas::proteínas::receptores citoplásmicos y nucleares::receptores de esteroides::receptores de andrógenos [COMPUESTOS QUÍMICOS Y DROGAS], Androgens, lcsh:Medicine (General), Case-Control Studie, Research Paper, hormonas, sustitutos de hormonas y antagonistas de hormonas::hormonas::hormonas gonadales::hormonas esteroides gonadales::congéneres de la testosterona::testosterona [COMPUESTOS QUÍMICOS Y DROGAS], Human, medicine.medical_specialty, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Andrògens - Receptors, Internal medicine, Severity of illness, medicine, Adjuvant therapy, Allele, Polymorphism, business.industry, Otros calificadores::/uso terapéutico [Otros calificadores], Public health, Risk Factor, lcsh:R, Case-control study, Androgen receptor, 030104 developmental biology, business, Andrògens
Abstract

Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Gen receptor d'andrògens; Infecció vírica i genoma de l’hoste Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Gen receptor de andrógenos; Infección viral y genoma del huésped Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Androgen receptor gene; Viral infection and host genome Background While SARS-CoV-2 similarly infects men and women, COVID-19 outcome is less favorable in men. Variability in COVID-19 severity may be explained by differences in the host genome. Methods We compared poly-amino acids variability from WES data in severely affected COVID-19 patients versus SARS-CoV-2 PCR-positive oligo-asymptomatic subjects. Findings Shorter polyQ alleles (≤22) in the androgen receptor (AR) conferred protection against severe outcome in COVID-19 in the first tested cohort (both males and females) of 638 Italian subjects. The association between long polyQ alleles (≥23) and severe clinical outcome (p = 0.024) was also validated in an independent cohort of Spanish men

Published
2021

37. Interaction between lysine 102 and aspartate 338 in the insect amino acid cotransporter KAAT1

Author

Castagna, M., Soragna, A., Mari, S.A., Santacroce, M., Bette, S., Mandela, P.G., Rudnick, G., Peres, A., and Sacchi, V.F.

Subjects
Lysine -- Properties, Aspartate -- Properties, Biological transport -- Evaluation, Physiological research, Biological sciences
Abstract

KAAT1 is a lepidopteran neutral amino acid transporter belonging to the NSS super family (SLC6), which has an unusual cation selectivity, being activated by [K.sup.+] and [Li.sup.+] in addition to [Na.sup.+]. We have previously demonstrated that Asp338 is essential for KAAT1 activation by [K.sup.+] and for the coupling of amino acid and driver ion fluxes. By comparing sequences of NSS family members, site-directed mutagenesis, and expression in Xenopus laevis oocytes, we identified Lysl02 as a residue likely to interact with Asp338. Compared with wild type, the single mutants K102V and D338E each showed altered leucine uptake and transport-associated currents in the presence of both [Na.sup.+] and [K.sup.+]. However, in K102V/D338E double mutant, the K102V mutation reversed both the inhibition of [Na.sup.+]-dependent transport and the block in [K.sup.+]-dependent transport that characterize the D338E mutant. [K.sup.+]-dependent leucine currents were not observed in any mutants with D338E. In the presence of the oxidant Cu(II) [(1,10-phenanthroline).sub.3], we observed specific and reversible inhibition of K102C/D338C mutant, but not of the corresponding single cysteine mutants, suggesting that these residues are sufficiently close to form a disulfide bond. Thus both structural and functional evidence suggests that these two residues interact. Similar results have been obtained mutating the bacterial transporter homolog TnaT. Asp338 corresponds to Asn286, a residue located in the [Na.sup.+] binding site in the recently solved crystal structure of the NSS transporter [LeuT.sub.Aa] (41). Our results suggest that Lysl02, interacting with Asp338, could contribute to the spatial organization of KAAT1 cation binding site and permeation pathway. residue interaction; oxidants; tertiary structure

Published
2007

38. Small papillary thyroid carcinoma with minimal extrathyroidal extension should be managed as ATA low-risk tumor

Author

nbsp, Castagna, M. &nbsp, Forleo, R., Maino, F., Fralassi, N., Barbato, F., Palmitesta, P., Pilli, T., Capezzone, M., Brilli, L., Ciuoli, C., Cantara, S., Formichi, C., and Pacini, F.

Subjects
Adult, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Disease, Gastroenterology, Papillary thyroid cancer, Thyroid carcinoma, Young Adult, 03 medical and health sciences, aggressive histology, micropapillary thyroid cancer, minimal extrathyroidal extension, PTC, tumor diameter, 0302 clinical medicine, Endocrinology, Risk Factors, Internal medicine, Humans, Medicine, Voluntary Health Agencies, Child, Lymph node, Aged, Retrospective Studies, Aged, 80 and over, Tumor size, business.industry, Thyroid, Disease Management, Guideline, Middle Aged, medicine.disease, Dissection, medicine.anatomical_structure, Thyroid Cancer, Papillary, 030220 oncology & carcinogenesis, Practice Guidelines as Topic, Thyroidectomy, Female, business, Follow-Up Studies
Abstract

According to American Thyroid Association (ATA) guideline, papillary thyroid cancer (PTC) with minimal extrathyroidal extension (mETE) is classified at “intermediate risk” of persistent/recurrent disease. However, the impact of mETE per se on patients’ outcome is not fully understood. The aim of our study was to evaluate the prognostic significance of mETE in patients with PTC not submitted to therapeutic or prophylactic lymph node dissection, according to tumor size and other prognostic factors. We retrospectively evaluated a total of 514 PTC patients: 127 (24.7%) had mETE (pT3Nx) and 387 (75.3%) had negative margins (pT1-2Nx). At a median follow-up of 9.1 years, patients were divided in two groups: patients with “good outcome” (no evidence of disease) and patients with “poor outcome” (persistent structural disease or recurrent disease or tumor-related death). The rate of patients with “poor outcome” was significantly higher in patients with mETE compared with patients with negative margins (11.8 versus 5.1%; OR 2.4576, 95% CI 1.2178–4.9594, p = 0.01). However, mETE was significantly associated with poor outcome only in patients with tumors larger than 1.5 cm. mETE is an unfavorable prognostic factor in tumors larger than 1.5 cm, suggesting that, in the absence of other unfavorable characteristics, smaller tumors with mETE should be classified and managed as “low risk” tumors.

Published
2018

49. Modified-Release Recombinant Human TSH (MRrhTSH) Augments the Effect of 131I Therapy in Benign Multinodular Goiter: Results from a Multicenter International, Randomized, Placebo-Controlled Study

Author

Graf, H., Fast, S., Pacini, F., Pinchera, A., Leung, A., Vaisman, M., Reiners, C., Wemeau, J. L., Huysmans, D., Harper, W., Driedger, A., de Souza, H. Noemberg, Castagna, M. G., Antonangeli, L., Braverman, L., Corbo, R., Düren, C., Proust-Lemoine, E., Edelbroek, M. A., Marriott, C., Rachinsky, I., Grupe, P., Watt, T., Magner, J., and Hegedus, L.

Published
2011

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