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3. Cover

Author

Castagna, Luca

Published
2014

4. Preface

Author

Castagna, Luca

Published
2014

15. Busulfan-fludarabine versus busulfan-cyclophosphamide for allogeneic transplant in acute myeloid leukemia: long term analysis of GITMO AML-R2 trial

Author

Cavallaro, Gianluca, Grassi, Anna, Pavoni, Chiara, Micò, Maria Caterina, Busca, Alessandro, Cavattoni, Irene Maria, Santarone, Stella, Borghero, Carlo, Olivieri, Attilio, Milone, Giuseppe, Chiusolo, Patrizia, Musto, Pellegrino, Saccardi, Riccardo, Patriarca, Francesca, Pane, Fabrizio, Saporiti, Giorgia, Rivela, Paolo, Terruzzi, Elisabetta, Cerretti, Raffaella, Marotta, Giuseppe, Carella, Angelo Michele, Nagler, Arnon, Russo, Domenico, Corradini, Paolo, Bernasconi, Paolo, Iori, Anna Paola, Castagna, Luca, Mordini, Nicola, Oldani, Elena, Di Grazia, Carmen, Bacigalupo, Andrea, and Rambaldi, Alessandro

Published
2024
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16. Venetoclax plus decitabine as a bridge to allogeneic haematopoietic stem-cell transplantation in older patients with acute myeloid leukaemia (VEN-DEC GITMO): final report of a multicentre, single-arm, phase 2 trial

Author

Russo, Domenico, Polverelli, Nicola, Bernardi, Simona, Santarone, Stella, Farina, Mirko, Borlenghi, Erika, Onida, Francesco, Castagna, Luca, Bramanti, Stefania, Carella, Angelo Michele, Sorasio, Roberto, Martino, Massimo, Alati, Caterina, Olivieri, Attilio, Beltrami, Germana, Curti, Antonio, Vetro, Calogero, Leotta, Salvatore, Mancini, Valentina, Terruzzi, Elisabetta, Bernardi, Massimo, Galieni, Piero, Musto, Pellegrino, Cerretti, Raffaella, Giaccone, Luisa, Skert, Cristina, Radici, Vera, Vezzoli, Marika, Calza, Stefano, Leoni, Alessandro, Garuffo, Luca, Bonvicini, Cristian, Pellizzeri, Simone, Malagola, Michele, and Ciceri, Fabio

Published
2024
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17. Reduced post-transplant cyclophosphamide doses in haploidentical hematopoietic cell transplantation for elderly patients with hematological malignancies

Author

Duléry, Rémy, Goudet, Claire, Mannina, Daniele, Bianchessi, Antonio, Granata, Angela, Harbi, Samia, Maisano, Valerio, Chabannon, Christian, Malard, Florent, Brissot, Eolia, Sestili, Simona, Banet, Anne, Van de Wyngaert, Zoé, Belhocine, Ramdane, Ederhy, Stéphane, Castagna, Luca, Bramanti, Stefania, Blaise, Didier, Mohty, Mohamad, Fürst, Sabine, and Devillier, Raynier

Published
2023
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18. Retrospective analysis of hematopoietic cell transplantation for blastic plasmacytoid dendritic cell neoplasm: conditioning intensity matters

Author

Bruch, Peter-Martin, Dietrich, Sascha, Finel, Herve, Boumendil, Ariane, Greinix, Hildegard, Heinicke, Thomas, Bethge, Wolfgang, Beelen, Dietrich, Schmid, Christoph, Martin, Hans, Castagna, Luca, Scheid, Christof, Schäfer-Eckart, Kerstin, Bittenbring, Jörg, Finke, Jürgen, Sengeloev, Henrik, Heiblig, Mael, Cornelissen, Jan, Chevallier, Patrice, Mohty, Mohamad, Robinson, Stephen, Montoto, Silvia, and Dreger, Peter

Published
2023
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19. Donor lymphocyte infusions after haploidentical stem cell transplantation with PTCY: A study on behalf of the EBMT cellular therapy & immunobiology working party

Author

Santoro, Nicole, Mooyaart, Jarl E., Devillier, Raynier, Koc, Yener, Vydra, Jan, Castagna, Luca, Gülbas, Zafer, Martin, José Diez, Araujo, Mercedes Colorado, Kulagin, Alexander, Arat, Mutlu, Arroyo, Concepcion Herrera, Martelli, Maria Paola, Di Ianni, Mauro, Hoogenboom, Jorinde D., de Wreede, Liesbeth C., Ruggeri, Annalisa, and Chabannon, Christian

Published
2023
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20. Impact of second-degree related donor on the outcomes of T cell-replete haploidentical transplantation with post-transplant cyclophosphamide

Author

Mariotti, Jacopo, Raiola, Anna Maria, Evangelista, Andrea, Harbi, Samia, Patriarca, Francesca, Carella, Michele Angelo, Martino, Massimo, Risitano, Antonio, Busca, Alessandro, Giaccone, Luisa, Brunello, Lucia, Merla, Emanuela, Savino, Lucia, Loteta, Barbara, Console, Giuseppe, Fanin, Renato, Sperotto, Alessandra, Marano, Luana, Marotta, Serena, Frieri, Camilla, Sica, Simona, Chiusolo, Patrizia, Chabannon, Christian, Furst, Sabine, Santoro, Armando, Bacigalupo, Andrea, Bruno, Benedetto, Blaise, Didier, Mavilio, Domenico, Bramanti, Stefania, Devillier, Raynier, Angelucci, Emanuele, and Castagna, Luca

Published
2022
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21. Selected memory T cells infused post–haploidentical hematopoietic stem cell transplantation persist and hyperexpand

Author

van Beek, Jasper J. P., Puccio, Simone, Di Vito, Clara, De Paoli, Federica, Zaghi, Elisa, Calvi, Michela, Scarpa, Alice, Peano, Clelia, Basso, Gianluca, Cibella, Javier, De Philippis, Chiara, Sarina, Barbara, Timofeeva, Inna, Capizzuto, Rossana, Mannina, Daniele, Mineri, Rossana, Mariotti, Jacopo, Crocchiolo, Roberto, Santoro, Armando, Castagna, Luca, Bramanti, Stefania, Mavilio, Domenico, and Lugli, Enrico

Published
2023
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22. Clinical applications of donor lymphocyte infusion from an HLA-haploidentical donor: consensus recommendations from the Acute Leukemia Working Party of the EBMT

Author

Dholaria, Bhagirathbhai, Savani, Bipin N, Labopin, Myriam, Luznik, Leo, Ruggeri, Annalisa, Mielke, Stephan, Malki, Monzr M Al, Kongtim, Piyanuch, Fuchs, Ephraim, Huang, Xiao-Jun, Locatelli, Franco, Aversa, Franco, Castagna, Luca, Bacigalupo, Andrea, Martelli, Massimo, Blaise, Didier, Soussan, Patrick Ben, Arnault, Yolande, Handgretinger, Rupert, Roy, Denis-Claude, O’Donnell, Paul, Bashey, Asad, Solomon, Scott, Romee, Rizwan, Lewalle, Philippe, Gayoso, Jorge, Maschan, Michael, Lazarus, Hillard M, Ballen, Karen, Giebel, Sebastian, Baron, Frederic, Ciceri, Fabio, Esteve, Jordi, Gorin, Norbert-Claude, Spyridonidis, Alexandros, Schmid, Christoph, Ciurea, Stefan O, Nagler, Arnon, and Mohty, Mohamad

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Immunology, Transplantation, Cancer, Regenerative Medicine, Rare Diseases, Prevention, Hematology, Stem Cell Research, Inflammatory and immune system, Consensus, Graft vs Host Disease, Hematopoietic Stem Cell Transplantation, Humans, Lymphocytes, Prospective Studies, Retrospective Studies, Cardiorespiratory Medicine and Haematology, Cardiovascular medicine and haematology
Abstract

Donor lymphocyte infusion has been used in the management of relapsed hematologic malignancies after allogeneic hematopoietic cell transplantation. It can eradicate minimal residual disease or be used to rescue a hematologic relapse, being able to induce durable remissions in a subset of patients. With the increased use of haploidentical hematopoietic cell transplantation, there is renewed interest in the use of donor lymphocytes to either treat or prevent disease relapse post transplant. Published retrospective and small prospective studies have shown encouraging results with therapeutic donor lymphocyte infusion in different haploidentical transplantation platforms. In this consensus paper, finalized on behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation, we summarize the available evidence on the use of donor lymphocyte infusion from haploidentical donor, and provide recommendations on its therapeutic, pre-emptive and prophylactic use in clinical practice.

Published
2020

24. Reduced intensity versus non-myeloablative conditioning regimen for haploidentical transplantation and post-transplantation cyclophosphamide in complete remission acute myeloid leukemia: a study from the ALWP of the EBMT

Author

Devillier, Raynier, Galimard, Jacques-Emmanuel, Labopin, Myriam, Blaise, Didier, Raiola, Anna Maria, Pavlu, Jiri, Castagna, Luca, Socié, Gerard, Chalandon, Yves, Martino, Massimo, Stölzel, Friedrich, Bug, Gesine, Bruno, Benedetto, Vrhovac, Radovan, Charbonnier, Amandine, Olivieri, Attilio, Bay, Jacques-Olivier, Arroyo, Herrera, Yakoub-Agha, Ibrahim, Avenoso, Daniele, Neubauer, Andreas, Nguyen, Stéphanie, Forcade, Edouard, Brissot, Eolia, Savani, Bipin, Nagler, Arnon, and Mohty, Mohamad

Published
2022
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25. Impact of donor kinship on non-T-cell depleted haploidentical stem cell transplantation with post transplantation cyclophosphamide for acute leukemia: From the ALWP of the EBMT

Author

Danylesko, Ivetta, Peczynski, Christophe, Labopin, Myriam, Polge, Emmanuelle, Tischer, Johanna, Blaise, Didier, Koc, Yener, Gülbas, Zafer, Ciceri, Fabio, Arat, Mutlu, Castagna, Luca, Bruno, Benedetto, Raiola, Anna Maria, Botella-Garcia, Carmen, Savani, Bipin N., Piemontese, Simona, Ruggeri, Annalisa, Nagler, Arnon, and Mohty, Mohamad

Published
2022
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26. PTCy-based haploidentical vs matched related or unrelated donor reduced-intensity conditioning transplant for DLBCL.

Author

Dreger, Peter, Sureda, Anna, Ahn, Kwang, Eapen, Mary, Litovich, Carlos, Finel, Herve, Boumendil, Ariane, Gopal, Ajay, Herrera, Alex, Schmid, Christoph, Diez-Martin, José, Fuchs, Ephraim, Bolaños-Meade, Javier, Gooptu, Mahasweta, Al Malki, Monzr, Castagna, Luca, Ciurea, Stefan, Dominietto, Alida, Blaise, Didier, Ciceri, Fabio, Tischer, Johanna, Corradini, Paolo, Montoto, Silvia, Robinson, Stephen, Gülbas, Zafer, and Hamadani, Mehdi

Subjects
Adult, Aged, Female, Hematopoietic Stem Cell Transplantation, Humans, Lymphoma, Large B-Cell, Diffuse, Male, Middle Aged, Retrospective Studies, Tissue Donors, Transplantation Conditioning, Young Adult
Abstract

This study retrospectively compared long-term outcomes of nonmyeloablative/reduced intensity conditioning (NMC/RIC) allogeneic hematopoietic cell transplantation (allo-HCT) from a haploidentical family donor (haplo-HCT) using posttransplant cyclophosphamide (PTCy) with those of matched sibling donor (MSD) and matched unrelated donor (MUD) with or without T-cell depletion (TCD+/TCD-) in patients with relapsed diffuse large B-cell lymphoma (DLBCL). Adult patients with DLBCL who had undergone their first NMC/RIC allo-HCT between 2008 and 2015 were included. Recipients of haplo-HCT were limited to those receiving graft-versus-host disease (GVHD) prophylaxis with PTCy. GVHD prophylaxis in MSD was limited to calcineurin inhibitor (CNI)-based approaches without in vivo TCD, while MUD recipients received CNI-based prophylaxis with or without TCD. Outcome analyses for overall survival (OS) and progression-free survival (PFS), nonrelapse mortality (NRM), and disease relapse/progression were calculated. A total of 1438 patients (haplo, 132; MSD, 525; MUD TCD+, 403; and MUD TCD-, 378) were included. Patients with haplo donors were significantly older, had a better performance status and had more frequently received total body irradiation-based conditioning regimens and bone marrow grafts than MSD and MUD TCD+ or TCD-. 3-year OS, PFS, NRM and relapse/progression incidence after haplo-HCT was 46%, 38%, 22%, and 41%, respectively, and not significantly different from outcomes of matched donor transplants on multivariate analyses. Haplo-HCT was associated with a lower cumulative incidence of chronic GVHD compared with MSD, MUD TCD+/TCD-. NMC/RIC haplo-HCT with PTCy seems to be a valuable alternative for patients with DLBCL considered for allo-HCT but lacking a matched donor.

Published
2019

27. Post-transplant cyclophosphamide in one-antigen mismatched unrelated donor transplantation versus haploidentical transplantation in acute myeloid leukemia: a study from the Acute Leukemia Working Party of the EBMT

Author

Battipaglia, Giorgia, Galimard, Jacques-Emmanuel, Labopin, Myriam, Raiola, Anna Maria, Blaise, Didier, Ruggeri, Annalisa, Koc, Yener, Gülbas, Zafer, Vitek, Antonin, Sica, Simona, Diez-Martin, Jose Luiz, Castagna, Luca, Bruno, Benedetto, Rovira, Montserrat, Moiseev, Ivan, Martino, Massimo, Grillo, Giovanni, Araujo, Mercedes Colorado, Bulabois, Claude Eric, Nguyen, Stéphanie, Socié, Gerard, Arat, Mutlu, Pavlu, Jiri, Tischer, Johanna, Martin, Hans, Corral, Lucia Lopez, Choi, Goda, Forcade, Edouard, McDonald, Andrew, Pane, Fabrizio, Bazarbachi, Ali, Ciceri, Fabio, Nagler, Arnon, and Mohty, Mohamad

Published
2022
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29. Sorafenib maintenance after allogeneic stem cell transplantation in patients with FLT3+ AML receiving midostaurin during induction and consolidation: a retrospective analysis.

Author

Sapienza, Giuseppe, Castronovo, Marta, Tringali, Stefania, Bono, Roberto, Rotolo, Cristina, Mulè, Antonino, Calafiore, Valeria, Patti, Caterina, Agueli, Cecilia, Randazzo, Valentina, Santoro, Alessandra, Matranga, Domenica, and Castagna, Luca

Subjects
STEM cell transplantation, ACUTE myeloid leukemia, SORAFENIB, CAUSES of death, TREATMENT duration
Abstract

Introduction: Acute myeloid leukemia (AML) relapse is the main cause of death after allogeneic stem cell transplant (allo-SCT). In AML FLT3+, it was shown that Sorafenib used as maintenance therapy after allo-SCT, significantly reduces the risk of relapse and death. Methods: We analyzed 29 adult patients with FLT3m AML and underwent allogeneic stem cell transplant from 2019 to 2023. All patients received midostaurin plus conventional CT during induction and consolidation. After transplantation, Sorafenib maintenance was administered in all patients independently from MRD status at transplantation. Results: Sorafenib maintenance was applied in 18 patients out 29 patients (62%). Median time to start sorafenib was 100 days (range 37-225) and median duration of treatment was 775 days (range 140-1064). For the whole population (n=29), 2-year OS, LFS, and CIR was 76%, 68% and 28%, respectively. The median time to relapse was 137 days (range 49-246). For patients treated with sorafenib (n=18), the 2-year OS, LFS, and CIR were 94%, 84% and 11%, respectively. For the whole population, the 100-day NRM was 0% and 1-year NRM was 3%. Death was caused by transplant-associated thrombotic microangiopathy in 1 patient. For patients who were administered with Sorafenib, the 1-y NRM was 5%. Death was caused by transplant associated transplant-associated thrombotic microangiopathy. Discussion: This retrospective study suggests that sorafenib maintenance seem to be effective even in patients pre-treated with midostaurin. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Outcome of allogeneic transplantation for mature T-cell lymphomas: impact of donor source and disease characteristics

Author

Hamadani, Mehdi, Ngoya, Maud, Sureda, Anna, Bashir, Qaiser, Litovich, Carlos Alejandro, Finel, Hervé, Chen, Yue, Boumendil, Ariane, Zain, Jasmine, Castagna, Luca, Cashen, Amanda F., Blaise, Didier, Shadman, Mazyar, Pastano, Rocco, Khimani, Farhad, Arat, Mutlu, Dietrich, Sascha, Schmitz, Norbert, Glass, Bertram, Kharfan-Dabaja, Mohamed A., Corradini, Paolo, Sauter, Craig S., Montoto, Silvia, Kwon, Mi, Herrera, Alex F., and Dreger, Peter

Published
2022
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31. Busulfan or Treosulfan Conditioning Platform for Allogeneic Stem Cell Transplantation in Patients Aged >60 Y With Acute Myeloid Leukemia/Myelodysplastic Syndrome: A Subanalysis of the GITMO AlloEld Study

Author

Malagola, Michele, Polverelli, Nicola, Martino, Massimo, Patriarca, Francesca, Bruno, Benedetto, Giaccone, Luisa, Grillo, Giovanni, Bramanti, Stefania, Bernasconi, Paolo, De Gobbi, Marco, Natale, Annalisa, Terruzzi, Elisabetta, Olivieri, Attilio, Chiusolo, Patrizia, Carella, Angelo Michele, Casini, Marco, Maffini, Enrico, Nozzoli, Chiara, Mazza, Patrizio, Bassi, Simona, Onida, Francesco, Vacca, Adriana, Falcioni, Sadia, Luppi, Mario, Iori, Anna Paola, Pavone, Vincenzo, Skert, Cristina, Carluccio, Paola, Borghero, Carlo, Proia, Anna, Selleri, Carmine, Rubini, Vicky, Sacchi, Nicoletta, Oldani, Elena, Bonifazi, Francesca, Ciceri, Fabio, Russo, Domenico, Bernardi, Simona, Farina, Mirko, Fiore, Maria, Lupo Stanghellini, Maria Teresa, Fanin, Renato, Faraci, Danilo Giuseppe, Castagna, Luca, Colombo, Anna Amelia, Nicoli, Paolo, Santarone, Stella, Scortechini, Ilaria, Metafuni, Elisabetta, Merla, Emanuela, Cavattoni, Irene, Cutini, Ilaria, Mazzone, Annamaria, Saporiti, Giorgia, Canale, Filippo Antonio, Piras, Eugenia, Galieni, Piero, Debbia, Giulia, Rocca, Ursula La, Mele, Anna, Carobolante, Francesca, Elice, Francesca, and Fanelli, Fulvia

Published
2023
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32. The European Society for Blood and Marrow Transplantation (EBMT) Consensus Guidelines for the Detection and Treatment of Donor-specific Anti-HLA Antibodies (DSA) in Haploidentical Hematopoietic Cell Transplantation

Author

Ciurea, Stefan O, Cao, Kai, Fernandez-Vina, Marcelo, Kongtim, Piyanuch, Malki, Monzr Al, Fuchs, Ephraim, Luznik, Leo, Huang, Xiao-Jun, Ciceri, Fabio, Locatelli, Franco, Aversa, Franco, Castagna, Luca, Bacigalupo, Andrea, Martelli, Massimo, Blaise, Didier, Handgretinger, Rupert, Roy, Denis-Claude, O’Donnell, Paul, Bashey, Asad, Lazarus, Hillard M, Ballen, Karen, Savani, Bipin N, Mohty, Mohamad, and Nagler, Arnon

Subjects
Transplantation, Regenerative Medicine, Stem Cell Research, Organ Transplantation, Development of treatments and therapeutic interventions, 5.4 Surgery, Inflammatory and immune system, Bone Marrow Transplantation, Graft Rejection, HLA Antigens, Hematopoietic Stem Cell Transplantation, Humans, Isoantibodies, Tissue Donors, Transplantation, Haploidentical, Treatment Outcome, Clinical Sciences, Oncology and Carcinogenesis, Immunology
Abstract

Haploidentical donors are now increasingly considered for transplantation in the absence of HLA-matched donors or when an urgent transplant is needed. Donor-specific anti-HLA antibodies (DSA) have been recently recognized as an important barrier against successful engraftment of donor cells, which can affect transplant survival. DSA appear more prevalent in this type of transplant due to higher likelihood of alloimmunization of multiparous females against offspring's HLA antigens, and the degree of mismatch. Here we summarize the evidence for the role of DSA in the development of primary graft failure in haploidentical transplantation and provide consensus recommendations from the European Society for Blood and Marrow Transplant Group on testing, monitoring, and treatment of patients with DSA receiving haploidentical hematopoietic progenitor cell transplantation.

Published
2018

34. Post-Transplantation Cyclophosphamide-Based Graft-versus-Host Disease Prophylaxis in HLA-Matched and Haploidentical Donor Transplantation for Patients with Hodgkin Lymphoma: A Comparative Study of the Lymphoma Working Party of the European Society for Blood and Marrow Transplantation

Author

Montoro, Juan, Boumendil, Ariane, Finel, Hervé, Bramanti, Stefania, Castagna, Luca, Blaise, Didier, Dominietto, Alida, Kulagin, Aleksandr, Yakoub-Agha, Ibrahim, Tbakhi, Abdelghani, Solano, Carlos, Giebel, Sebastian, Gulbas, Zafer, López Corral, Lucía, Pérez-Simón, José A., Díez Martín, José Luis, Sanz, Jaime, Farina, Lucia, Koc, Yener, Socié, Gerard, Arat, Mutlu, Jurado, Manuel, Bermudez, Arancha, Labussière-Wallet, Hélène, Villalba, Marta, Ciceri, Fabio, Martinez, Carmen, Nagler, Arnon, Sureda, Anna, and Glass, Bertram

Published
2024
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35. Correction: Donor lymphocyte infusions after haploidentical stem cell transplantation with PTCY: A study on behalf of the EBMT cellular therapy & immunobiology working party

Author

Santoro, Nicole, Mooyaart, Jarl E., Devillier, Raynier, Koc, Yener, Vydra, Jan, Castagna, Luca, Gülbas, Zafer, Martin, José Diez, Araujo, Mercedes Colorado, Kulagin, Alexander, Arat, Mutlu, Arroyo, Concepcion Herrera, Martelli, Maria Paola, Di Ianni, Mauro, Hoogenboom, Jorinde D., de Wreede, Liesbeth C., Ruggeri, Annalisa, and Chabannon, Christian

Published
2023
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37. Allogeneic transplantation after PD-1 blockade for classic Hodgkin lymphoma

Author

Merryman, Reid W., Castagna, Luca, Giordano, Laura, Ho, Vincent T., Corradini, Paolo, Guidetti, Anna, Casadei, Beatrice, Bond, David A., Jaglowski, Samantha, Spinner, Michael A., Arai, Sally, Lowsky, Robert, Shah, Gunjan L., Perales, Miguel-Angel, De Colella, Jean Marc Schiano, Blaise, Didier, Herrera, Alex F., Shouse, Geoffrey, Spilleboudt, Chloe, Ansell, Stephen M., Nieto, Yago, Badar, Talha, Hamadani, Mehdi, Feldman, Tatyana A., Dahncke, Lori, Singh, Anurag K., McGuirk, Joseph P., Nishihori, Taiga, Chavez, Julio, Serritella, Anthony V., Kline, Justin, Mohty, Mohamad, Dulery, Remy, Stamatoulas, Aspasia, Houot, Roch, Manson, Guillaume, Moles-Moreau, Marie-Pierre, Orvain, Corentin, Bouabdallah, Kamal, Modi, Dipenkumar, Ramchandren, Radhakrishnan, Lekakis, Lazaros, Beitinjaneh, Amer, Frigault, Matthew J., Chen, Yi-Bin, Lynch, Ryan C., Smith, Stephen D., Rao, Uttam, Byrne, Michael, Romancik, Jason T., Cohen, Jonathon B., Nathan, Sunita, Phillips, Tycel, Joyce, Robin M., Rahimian, Maryam, Bashey, Asad, Ballard, Hatcher J., Svoboda, Jakub, Torri, Valter, Sollini, Martina, De Philippis, Chiara, Magagnoli, Massimo, Santoro, Armando, Armand, Philippe, Zinzani, Pier Luigi, and Carlo-Stella, Carmelo

Published
2021
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39. Prognostic factors for neutrophil engraftment after haploidentical cell transplantation with PT-Cy in patients with acute myeloid leukemia in complete remission, on behalf of the ALWP-EBMT

Author

Ruggeri, Annalisa, Labopin, Myriam, Angelucci, Emanuele, Blaise, Didier, Ciceri, Fabio, Koc, Yener, Chiusolo, Patrizia, Diez-Martin, Jose Luiz, Gülbas, Zafer, Castagna, Luca, Bruno, Benedetto, Arat, Mutlu, Martino, Massimo, Nagler, Arnon, and Mohty, Mohamad

Published
2021
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42. Post-Transplantation Cyclophosphamide-Based Graft-versus-Host Disease Prophylaxis in HLA-Matched and Haploidentical Donor Transplantation for Patients with Hodgkin Lymphoma: A Comparative Study of the Lymphoma Working Party of the European Society for Blood and Marrow Transplantation

Author

Pérez-Simón, José A. [0000-0003-3616-6101], Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72], Montoro, Juan, Boumendil, Ariane, Finel, Hervé, Bramanti, Stefania, Castagna, Luca, Blaise, Didier, Dominietto, Alida, Kulagin, Aleksandr, Yakoub-Agha, Ibrahim, Tbakhi, Abdelghani, Solano, Carlos, Giebel, Sebastian, Gulbas, Zafer, López-Corral, Lucía, Pérez-Simón, José A., Diez-Martin, José L., Sanz, Jaime, Farina, Lucia, Koc, Yener, Socié, Gerard, Arat, Mutlu, Jurado, Manuel, Bermúdez, Arancha, Labussiere-Wallet, Helene, Villalba, Marta, Ciceri, Fabio, Martínez, Carmen, Nagler, Arnon, Sureda, Anna, Glass, Bertram, Pérez-Simón, José A. [0000-0003-3616-6101], Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72], Montoro, Juan, Boumendil, Ariane, Finel, Hervé, Bramanti, Stefania, Castagna, Luca, Blaise, Didier, Dominietto, Alida, Kulagin, Aleksandr, Yakoub-Agha, Ibrahim, Tbakhi, Abdelghani, Solano, Carlos, Giebel, Sebastian, Gulbas, Zafer, López-Corral, Lucía, Pérez-Simón, José A., Diez-Martin, José L., Sanz, Jaime, Farina, Lucia, Koc, Yener, Socié, Gerard, Arat, Mutlu, Jurado, Manuel, Bermúdez, Arancha, Labussiere-Wallet, Helene, Villalba, Marta, Ciceri, Fabio, Martínez, Carmen, Nagler, Arnon, Sureda, Anna, and Glass, Bertram

Abstract

Post-transplantation cyclophosphamide (PTCy) has emerged as a promising approach for preventing graft-versus-host disease (GVHD) in allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, there is a lack of studies examining the impact of this GVHD prophylaxis when different donor types are used in patients with Hodgkin lymphoma (HL). This study compared the outcomes of patients with HL undergoing HSCT from HLA-matched donors, including matched sibling donors (MSDs) and matched unrelated donors (MUDs), and haploidentical donors, using PTCy as the GVHD prophylaxis approach in all cohorts. We retrospectively compared outcomes of allo-HSCT from 166 HLA-matched donors (96 sibling and 70 unrelated donors) and 694 haploidentical donors using PTCy-based GVHD prophylaxis in patients with HL registered in the European Society for Blood and Marrow Transplantation database from 2010 to 2020. Compared to HLA-matched HSCT, haploidentical donor HSCT was associated with a significantly lower rate of platelet engraftment (86% versus 94%; P < .001) and a higher rate of grade II-IV acute GVHD (34% versus 24%; P = .01). The 2-year cumulative incidence of nonrelapse mortality (NRM) was significantly lower in the HLA-matched cohort compared to the haploidentical cohort (10% versus 18%; P = .02), resulting in a higher overall survival (OS) rate (82% versus 70%; P = .002). There were no significant differences between the 2 cohorts in terms of relapse, progression-free survival, or GVHD-free relapse-free survival. In multivariable analysis, haploidentical HSCT was associated with an increased risk of grade II-IV acute GVHD and NRM and worse OS compared to HLA-matched HSCT. Our findings suggest that in the context of PTCy-based GVHD prophylaxis, transplantation from HLA-matched donors appears to be a more favorable option compared to haploidentical HSCT.

Published
2024

43. Nonmyeloablative Conditioning Regimen before T Cell Replete Haploidentical Transplantation with Post-Transplant Cyclophosphamide for Advanced Hodgkin and Non-Hodgkin Lymphomas

Author

Montes de Oca, Catalina, Castagna, Luca, De Philippis, Chiara, Bramanti, Stefania, Schiano, Jean Marc, Pagliardini, Thomas, Collignon, Aude, Harbi, Samia, Mariotti, Jacopo, Granata, Angela, Maisano, Valerio, Furst, Sabine, Legrand, Faezeah, Chabannon, Christian, Carlo-Stella, Carmelo, Santoro, Armando, Blaise, Didier, and Devillier, Raynier

Published
2020
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44. Allogeneic stem cell transplantation in poor prognosis peripheral T-cell lymphoma: the impact of different donor type on outcome

Author

Castagna, Luca, Pagliardini, Thomas, Bramanti, Stefania, Schiano de Colella, Jean Marc, Montes de Oca, Catalina, Bouabdallah, Reda, Mariotti, Jacopo, Fürst, Sabine, Granata, Angela, De Philippis, Chiara, Harbi, Samia, Sarina, Barbara, Legrand, Faezeh, Maisano, Valerio, Weiller, Pierre Jean, Chabannon, Christian, Carlo-Stella, Carmelo, Santoro, Armando, Blaise, Didier, and Devillier, Raynier

Published
2021
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45. Timing of Post-Transplantation Cyclophosphamide Administration in Haploidentical Transplantation: A Comparative Study on Behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Author

Ruggeri, Annalisa, Labopin, Myriam, Battipaglia, Giorgia, Chiusolo, Patrizia, Tischer, Johanna, Diez-Martin, Jean Luiz, Bruno, Benedetto, Castagna, Luca, Moiseev, Ivan Sergeevich, Vitek, Antonin, Rovira, Montserrat, Ciceri, Fabio, Bacigalupo, Andrea, Nagler, Arnon, and Mohty, Mohamad

Published
2020
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46. Impact of donor age and kinship on clinical outcomes after T-cell–replete haploidentical transplantation with PT-Cy

Author

Mariotti, Jacopo, Raiola, Anna Maria, Evangelista, Andrea, Carella, Angelo Michele, Martino, Massimo, Patriarca, Francesca, Risitano, Antonio, Bramanti, Stefania, Busca, Alessandro, Giaccone, Luisa, Brunello, Lucia, Merla, Emanuela, Savino, Lucia, Loteta, Barbara, Console, Giuseppe, Fanin, Renato, Sperotto, Alessandra, Marano, Luana, Marotta, Serena, Frieri, Camilla, Sica, Simona, Chiusolo, Patrizia, Harbi, Samia, Furst, Sabine, Santoro, Armando, Bacigalupo, Andrea, Blaise, Didier, Angelucci, Emanuele, Mavilio, Domenico, Castagna, Luca, and Bruno, Benedetto

Published
2020
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47. Haploidentical Transplantation with Post-Transplantation Cyclophosphamide for T Cell Acute Lymphoblastic Leukemia: A Report from the European Society for Blood and Marrow Transplantation Acute Leukemia Working Party

Author

Bazarbachi, Ali, Labopin, Myriam, Angelucci, Emanuele, Gülbas, Zafer, Ozdogu, Hakan, Arat, Mutlu, de Rosa, Luca, Pastano, Rocco, Pioltelli, Pietro, Montserrat, Rovira, Martino, Massimo, Ciceri, Fabio, Koç, Yener, Socié, Gerard, Blaise, Didier, Herrera, Concepcion, Chalandon, Yves, Bernasconi, Paolo, Marotta, Giuseppe, Castagna, Luca, McDonald, Andrew, Visani, Guiseppe, Carluccio, Paola, Vitek, Antonin, Simand, Célestine, Afanasyev, Boris, Rösler, Wolf, Diez-Martin, J.L., Nagler, Arnon, Brissot, Eolia, Giebel, Sebastian, and Mohty, Mohamad

Published
2020
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48. Effect of the Thiotepa Dose in the TBF Conditioning Regimen in Patients Undergoing Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia in Complete Remission: A Report From the EBMT Acute Leukemia Working Party

Author

El-Cheikh, Jean, Labopin, Myriam, Al-Chami, Farouk, Bazarbachi, Ali, Angelucci, Emanuele, Santarone, Stella, Bonifazi, Francesca, Carella, Angelo Michele, Castagna, Luca, Bruno, Benedetto, Iori, Anna Paola, La Nasa, Giorgio, Savani, Bipin, Nagler, Arnon, and Mohty, Mohamad

Published
2020
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49. Five-year results of the BEGEV salvage regimen in relapsed/refractory classical Hodgkin lymphoma

Author

Santoro, Armando, Mazza, Rita, Pulsoni, Alessandro, Re, Alessandro, Bonfichi, Maurizio, Zilioli, Vittorio Ruggero, Zanni, Manuela, Merli, Francesco, Anastasia, Antonella, Luminari, Stefano, Annechini, Giorgia, Gotti, Manuel, Peli, Annalisa, Liberati, Anna Marina, Di Renzo, Nicola, Castagna, Luca, Giordano, Laura, Ricci, Francesca, and Carlo-Stella, Carmelo

Published
2020
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50. Persistence of KIRneg NK cells after haploidentical hematopoietic stem cell transplantation protects from human cytomegalovirus infection/reactivation

Author

Di Vito, Clara, primary, Coianiz, Nicolò, additional, Calvi, Michela, additional, Terzoli, Sara, additional, Zaghi, Elisa, additional, Puccio, Simone, additional, Frigo, Alessandro, additional, Mariotti, Jacopo, additional, De Philippis, Chiara, additional, Mannina, Daniele, additional, Sarina, Barbara, additional, Mineri, Rossana, additional, Le-Trilling, Vu Thuy Khanh, additional, Trilling, Mirko, additional, Castagna, Luca, additional, Bramanti, Stefania, additional, Santoro, Armando, additional, and Mavilio, Domenico, additional

Published
2024
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