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399 results on '"Castaño, Argelia"'

1. Exposure to bisphenol A in European women from 2007 to 2014 using human biomonitoring data – The European Joint Programme HBM4EU

Author: Tagne-Fotso, Romuald, Riou, Margaux, Saoudi, Abdessattar, Zeghnoun, Abdelkrim, Frederiksen, Hanne, Berman, Tamar, Montazeri, Parisa, Andersson, Anna-Maria, Rodriguez-Martin, Laura, Akesson, Agneta, Berglund, Marika, Biot, Pierre, Castaño, Argelia, Charles, Marie-Aline, Cocco, Emmanuelle, Den Hond, Elly, Dewolf, Marie-Christine, Esteban-Lopez, Marta, Gilles, Liese, Govarts, Eva, Guignard, Cedric, Gutleb, Arno C., Hartmann, Christina, Kold Jensen, Tina, Koppen, Gudrun, Kosjek, Tina, Lambrechts, Nathalie, McEachan, Rosemary, Sakhi, Amrit K., Snoj Tratnik, Janja, Uhl, Maria, Urquiza, Jose, Vafeiadi, Marina, Van Nieuwenhuyse, An, Vrijheid, Martine, Weber, Till, Zaros, Cécile, Tarroja-Aulina, Elena, Knudsen, Lisbeth E., Covaci, Adrian, Barouki, Robert, Kolossa-Gehring, Marike, Schoeters, Greet, Denys, Sebastien, Fillol, Clemence, and Rambaud, Loïc
Published: 2024
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2. Lung Function and Symptoms of Exposure to the Volcanic Eruption in the Canary Islands: First Follow-Up of the ASHES Study

Author: Candal-Pedreira, Cristina, Díaz-Pérez, David, Velasco, Valle, Casanova, Ciro, Acosta, Orlando, Peces-Barba, Germán, Barreiro, Esther, Cañas, Ana, Castaño, Argelia, Cruz Carmona, María Jesús, Diego, Carmen, Garcia-Aymerich, Judith, Martínez, Cristina, Molina-Molina, María, Muñoz, Xavier, Sánchez-Íñigo, Francisco Javier, and Ruano-Ravina, Alberto
Published: 2024
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3. Association of exposure to perfluoroalkyl substances (PFAS) and phthalates with thyroid hormones in adolescents from HBM4EU aligned studies

Author: Rodríguez-Carrillo, Andrea, Salamanca-Fernández, Elena, den Hond, Elly, Verheyen, Veerle J., Fábelová, Lucia, Murinova, Lubica Palkovicova, Pedraza-Díaz, Susana, Castaño, Argelia, García-Lario, José Vicente, Remy, Sylvie, Govarts, Eva, Schoeters, Greet, Olea, Nicolás, Freire, Carmen, and Fernández, Mariana F.
Published: 2023
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4. HBM4EU-MOM: Prenatal methylmercury-exposure control in five countries through suitable dietary advice for pregnancy – Study design and characteristics of participants

Author: Katsonouri, Andromachi, Gabriel, Catherine, Esteban López, Marta, Namorado, Sonia, Halldorsson, Thorhallur I., Snoj Tratnik, Janja, Rodriguez Martin, Laura, Karakoltzidis, Achilleas, Chatzimpaloglou, Anthoula, Giannadaki, Despina, Anastasi, Elena, Thoma, Anthi, Domínguez-Morueco, Noelia, Cañas Portilla, Ana I., Jacobsen, Eva, Assunção, Ricardo, Peres, Maria, Santiago, Susana, Nunes, Carla, Pedraza-Diaz, Susana, Iavicoli, Ivo, Leso, Veruscka, Lacasaña, Marina, González-Alzaga, Beatriz, Horvat, Milena, Sepai, Ovnair, Castano, Argelia, Kolossa-Gehring, Marike, Karakitsios, Spyros, and Sarigiannis, Dimosthenis
Published: 2023
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5. A simple method for direct mercury analysis in dried blood spots (DBS) samples for human biomonitoring studies

Author: González-Rubio, Juana María, Domínguez-Morueco, Noelia, Pedraza-Díaz, Susana, Cañas Portilla, Ana, Lucena, Miguel Ángel, Rodriguez, Ana, Castaño, Argelia, and Esteban-López, Marta
Published: 2023
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6. HBM4EU chromates study – the measurement of hexavalent and trivalent chromium in exhaled breath condensate samples from occupationally exposed workers across Europe

Author: Anzion, Rob, Cattaneo, Andrea, Cavallo, Domenico Maria, De Palma, Giuseppe, Forte, Giovanni, Lehtinen, Risto, Lovreglio, Piero, Melczer, Mathieu, Senofonte, Marta, Spankie, Sally, van Dael, Maurice, Leese, Elizabeth, Jones, Kate, Bocca, Beatrice, Bousoumah, Radia, Castaño, Argelia, Galea, Karen S, Iavicoli, Ivo, López, Marta Esteban, Leso, Veruscka, Ndaw, Sophie, Porras, Simo P., Ruggieri, Flavia, Scheepers, Paul T.J, and Santonen, Tiina
Published: 2023
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7. PFAS association with kisspeptin and sex hormones in teenagers of the HBM4EU aligned studies

Author: Rodríguez-Carrillo, Andrea, Remy, Sylvie, Koppen, Gudrun, Wauters, Natasha, Freire, Carmen, Olivas-Martínez, Alicia, Schillemans, Tessa, Åkesson, Agneta, Desalegn, Anteneh, Iszatt, Nina, den Hond, Elly, Verheyen, Veerle, Fábelová, Lucia, Murinova, Lubica Palkovicova, Pedraza-Díaz, Susana, Castaño, Argelia, García-Lario, José Vicente, Cox, Bianca, Govarts, Eva, Baken, Kirsten, Tena-Sempere, Manuel, Olea, Nicolás, Schoeters, Greet, and Fernández, Mariana F.
Published: 2023
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8. Interlaboratory Comparison Investigations (ICIs) and External Quality Assurance Schemes (EQUASs) for human biomonitoring of perfluoroalkyl substances (PFASs) in serum as part of the quality assurance programme under HBM4EU

Author: Nübler, Stefanie, Esteban López, Marta, Castaño, Argelia, Mol, Hans G.J., Haji-Abbas-Zarrabi, Karin, Schäfer, Moritz, Müller, Johannes, Hajslova, Jana, Dvorakova, Darina, Antignac, Jean-Philippe, Koch, Holger M., Haug, Line Småstuen, Vorkamp, Katrin, and Göen, Thomas
Published: 2022
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9. Interlaboratory Comparison Investigations (ICIs) for human biomonitoring of chromium as part of the quality assurance programme under HBM4EU

Author: Nübler, Stefanie, Schäfer, Moritz, Haji-Abbas-Zarrabi, Karin, Marković, Stefan, Marković, Katarina, Esteban López, Marta, Castaño, Argelia, Mol, Hans, Koch, Holger M., Antignac, Jean-Philippe, Hajslova, Jana, Thomsen, Cathrine, Vorkamp, Katrin, and Göen, Thomas
Published: 2022
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10. HBM4EU chromates study - Overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromium

Author: Aimonen, Kukka, Antoine, Guillaume, Anzion, Rob, Burgart, Manuella, Castaño, Argelia, Cattaneo, Andrea, Cavallo, Domenico Maria, De Palma, Giuseppe, Denis, Flavien, Gambelunghe, Angela, Gomes, Bruno, Hanser, Ogier, Helenius, Riikka, Ladeira, Carina, López, Marta Esteban, Lovreglio, Piero, Marsan, Philippe, Melczer, Mathieu, Nogueira, Ana, Pletea, Elisabeta, Poels, Katrien, Remes, Jouko, Ribeiro, Edna, Santos, Sílvia Reis, Schaefers, Françoise, Spankie, Sally, Spoek, Robert, Rizki, Mohamed, Rousset, Davy, van Dael, Maurice, Veijalainen, Henna, Santonen, Tiina, Porras, Simo P., Bocca, Beatrice, Bousoumah, Radia, Duca, Radu Corneliu, Galea, Karen S., Godderis, Lode, Göen, Thomas, Hardy, Emilie, Iavicoli, Ivo, Janasik, Beata, Jones, Kate, Leese, Elizabeth, Leso, Veruscka, Louro, Henriqueta, Majery, Nicole, Ndaw, Sophie, Pinhal, Hermínia, Ruggieri, Flavia, Silva, Maria J., van Nieuwenhuyse, An, Verdonck, Jelle, Viegas, Susana, Wasowicz, Wojciech, Sepai, Ovnair, and Scheepers, Paul T.J.
Published: 2022
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11. Towards harmonised criteria in quality assurance and quality control of suspect and non-target LC-HRMS analytical workflows for screening of emerging contaminants in human biomonitoring

Author: Caballero-Casero, Noelia, Belova, Lidia, Vervliet, Philippe, Antignac, Jean-Philippe, Castaño, Argelia, Debrauwer, Laurent, López, Marta Esteban, Huber, Carolin, Klanova, Jana, Krauss, Martin, Lommen, Arjen, Mol, Hans G.J., Oberacher, Herbert, Pardo, Olga, Price, Elliott J., Reinstadler, Vera, Vitale, Chiara Maria, van Nuijs, Alexander L.N., and Covaci, Adrian
Published: 2021
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12. Time Patterns in Internal Human Exposure Data to Bisphenols, Phthalates, DINCH, Organophosphate Flame Retardants, Cadmium and Polyaromatic Hydrocarbons in Europe

Author: Rodriguez Martin, Laura Rodriguez, primary, Gilles, Liese, additional, Helte, Emilie, additional, Åkesson, Agneta, additional, Tägt, Jonas, additional, Covaci, Adrian, additional, Sakhi, Amrit K., additional, Van Nieuwenhuyse, An Van, additional, Katsonouri, Andromachi, additional, Andersson, Anna-Maria, additional, Gutleb, Arno C., additional, Janasik, Beata, additional, Appenzeller, Brice, additional, Gabriel, Catherine, additional, Thomsen, Cathrine, additional, Mazej, Darja, additional, Sarigiannis, Denis, additional, Anastasi, Elena, additional, Barbone, Fabio, additional, Tolonen, Hanna, additional, Frederiksen, Hanne, additional, Klanova, Jana, additional, Koponen, Jani, additional, Tratnik, Janja Snoj, additional, Pack, Kim, additional, Gudrun, Koppen, additional, Ólafsdóttir, Kristin, additional, Knudsen, Lisbeth, additional, Rambaud, Loïc, additional, Strumylaite, Loreta, additional, Murinova, Lubica Palkovicova, additional, Fabelova, Lucia, additional, Riou, Margaux, additional, Berglund, Marika, additional, Szabados, Maté, additional, Imboden, Medea, additional, Laeremans, Michelle, additional, Eštóková, Milada, additional, Holcer, Natasa Janev, additional, Probst-Hensch, Nicole, additional, Vodrazkova, Nicole, additional, Vogel, Nina, additional, Piler, Pavel, additional, Schmidt, Phillipp, additional, Lange, Rosa, additional, Namorado, Sónia, additional, Kozepesy, Szilvia, additional, Szigeti, Tamás, additional, Halldorsson, Thorhallur I., additional, Weber, Till, additional, Jensen, Tina Kold, additional, Rosolen, Valentina, additional, Puklova, Vladimira, additional, Wasowicz, Wojciech, additional, Sepai, Ovnair, additional, Stewart, Lorraine, additional, Kolossa-Gehring, Marike, additional, Esteban-López, Marta, additional, Castaño, Argelia, additional, Bessems, Jos, additional, Schoeters, Greet, additional, and Govarts, Eva, additional
Published: 2023
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13. HBM4EU chromates study – the measurement of hexavalent and trivalent chromium in exhaled breath condensate samples from occupationally exposed workers across Europe

Author: Leese, Elizabeth., Jones, Kate, Bocca, Beatrice, Bousoumah, Radia, Castaño, Argelia, Galea, Karen S, Iavicoli, Ivo, López, Marta Esteban, Leso, Veruscka, Ndaw, Sophie, Porras, Simo P., Ruggieri, Flavia, Scheepers, Paul T. J., Santonen, Tiina, Anzion, Rob, Cattaneo, Andrea, Cavallo, Domenico Maria, De Palma, Giuseppe, Forte, Giovanni, Lehtinen, Risto, Lovreglio, Piero, Melczer, Mathieu, Senofonte, Marta, Spankie, Sally, van Dael, Maurice, Leese, E., Jones, K., Bocca, B., Bousoumah, R., Castano, A., Galea, K. S., Iavicoli, I., Lopez, M. E., Leso, V., Ndaw, S., Porras, S. P., Ruggieri, F., Scheepers, P. T. J., and Santonen, T.
Subjects: Chrome platers, Human biomonitoring, Chromium speciation, EBC, Welders, Chrome plater, General Medicine, Toxicology, Environmental Sciences
Abstract: The aim of this study was to investigate the practicability of exhaled breath condensate (EBC) as a biological matrix to detect and measure hexavalent chromium (Cr(VI)) and trivalent chromium (Cr(III)) in workers occupationally exposed to Cr(VI). EBC samples were collected from workers in France, Finland, Italy, The Netherlands and the United Kingdom from three different target activities: chrome platers, stainless steel welders and surface treatment workers. Pre and post working week EBC samples were collected from 177 exposed workers and 98 unexposed workers (control group). Hyphenated chromatography systems with inductively coupled plasma - mass spectrometry (ICP-MS) were for the analysis. The results showed that the occupationally exposed workers had significantly higher levels of Cr(VI) and Cr(III) than the control group. Chrome platers exhibited the highest Cr(VI) levels in their EBC samples, with a significant increase from their pre to post samples for both Cr(VI) and Cr(III). A significant difference was also found between pre and post EBC samples for Cr(III) in welders. This study has shown that EBC has the potential to be a valid, non-invasive biological matrix to assess occupational exposure to Cr(VI) and Cr(III) for biological monitoring assessment, with the ability to detect low level inhalation exposures.
Published: 2023

14. Special issue editorial: Key results of the european human biomonitoring initiative - HBM4EU

Author: Kolossa-Gehring, Marike, primary, Schoeters, Greet, additional, Castaño, Argelia, additional, Barouki, Robert, additional, Haines, Douglas, additional, Polcher, Alexandra, additional, and Weise, Philipp, additional
Published: 2023
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15. Application of human biomonitoring data to support policy development, raise awareness and environmental public health protection among countries within the HBM4EU project

Author: Ubong, Dorothy, primary, Stewart, Lorraine, additional, Sepai, Ovnair, additional, Knudsen, Lisbeth E., additional, Berman, Tamar, additional, Reynders, Hans, additional, Van Campenhout, Karen, additional, Katsonouri, Andromachi, additional, Van Nieuwenhuyse, An, additional, Ingelido, Anna Maria, additional, Castaño, Argelia, additional, Pedraza-Díaz, Susana, additional, Eiríksdóttir, Ása Valgerður, additional, Thomsen, Cathrine, additional, Hartmann, Christina, additional, Gjorgjev, Dragan, additional, De Felip, Elena, additional, Tolonen, Hanna, additional, Santonen, Tiina, additional, klanova, Jana, additional, Norström, Karin, additional, Kononenko, Lijana, additional, Silva, Maria João, additional, Uhl, Maria, additional, Kolossa-Gehring, Marike, additional, Apel, Petra, additional, Jõemaa, Merli, additional, Jajcaj, Michal, additional, Estokova, Milada, additional, Luijten, Mirjam, additional, Lebret, Erik, additional, von Goetz, Natalie, additional, Holcer, Natasa Janev, additional, Probst-Hensch, Nicole, additional, Cavaleiro, Rita, additional, Barouki, Robert, additional, Tarroja, Elena, additional, Balčienė, Rosita Marija, additional, Strumylaite, Loreta, additional, Latvala, Siiri, additional, Namorado, Sónia, additional, Szigeti, Tamás, additional, Ingi Halldorsson, Thorhallur, additional, Olafsdottir, Kristin, additional, Wasowicz, Wojciech, additional, Viegas, Susana, additional, and Alvito, Paula, additional
Published: 2023
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16. Coordination of chemical analyses under the European Human Biomonitoring Initiative (HBM4EU): Concepts, procedures and lessons learnt

Author: Vorkamp, Katrin, primary, Esteban López, Marta, additional, Gilles, Liese, additional, Göen, Thomas, additional, Govarts, Eva, additional, Hajeb, Parvaneh, additional, Katsonouri, Andromachi, additional, Knudsen, Lisbeth E., additional, Kolossa-Gehring, Marike, additional, Lindh, Christian, additional, Nübler, Stefanie, additional, Pedraza-Díaz, Susana, additional, Santonen, Tiina, additional, and Castaño, Argelia, additional
Published: 2023
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17. Sensitive Instrumental Method for Quantitative Determination of High-Brominated Flame Retardants in Human Serum Samples

Author: Grande, Cristina, primary, Castaño, Argelia, additional, and Ramos, Juan José, additional
Published: 2023
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18. External Quality Assurance Schemes (EQUASs) and Inter-laboratory Comparison Investigations (ICIs) for human biomonitoring of polycyclic aromatic hydrocarbon (PAH) biomarkers in urine as part of the quality assurance programme under HBM4EU

Author: Nübler, Stefanie, primary, Esteban López, Marta, additional, Castaño, Argelia, additional, Mol, Hans G.J., additional, Müller, Johannes, additional, Schäfer, Moritz, additional, Haji-Abbas-Zarrabi, Karin, additional, Hajslova, Jana, additional, Pulkrabova, Jana, additional, Dvorakova, Darina, additional, Urbancova, Katerina, additional, Koch, Holger M., additional, Antignac, Jean-Philippe, additional, Sakhi, Amrit Kaur, additional, Vorkamp, Katrin, additional, Burkhardt, Therese, additional, Scherer, Max, additional, and Göen, Thomas, additional
Published: 2023
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19. A step towards harmonising human biomonitoring study setup on European level: Materials provided and lessons learnt in HBM4EU

Author: Pack, L. Kim, primary, Gilles, Liese, additional, Cops, Jirka, additional, Tolonen, Hanna, additional, van Kamp, Irene, additional, Esteban-López, Marta, additional, Pedraza-Díaz, Susana, additional, Lacasaña, Marina, additional, Alzaga, Beatriz González, additional, Lermen, Dominik, additional, Bartel-Steinbach, Martina, additional, Katsonouri, Andromachi, additional, Fiddicke, Ulrike, additional, Castaño, Argelia, additional, and Kolossa-Gehring, Marike, additional
Published: 2023
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20. Current exposure to phthalates and DINCH in European children and adolescents – Results from the HBM4EU Aligned Studies 2014 to 2021

Author: Vogel, Nina, primary, Schmidt, Phillipp, additional, Lange, Rosa, additional, Gerofke, Antje, additional, Sakhi, Amrit K., additional, Haug, Line S., additional, Jensen, Tina Kold, additional, Frederiksen, Hanne, additional, Szigeti, Tamás, additional, Csákó, Zsófia, additional, Murinova, Lubica Palkovicova, additional, Sidlovska, Miroslava, additional, Janasik, Beata, additional, Wasowicz, Wojciech, additional, Tratnik, Janja Snoj, additional, Mazej, Darja, additional, Gabriel, Catherine, additional, Karakitsios, Spyros, additional, Barbone, Fabio, additional, Rosolen, Valentina, additional, Rambaud, Loïc, additional, Riou, Margaux, additional, Murawski, Aline, additional, Leseman, Daan, additional, Koppen, Gudrun, additional, Covaci, Adrian, additional, Lignell, Sanna, additional, Lindroos, Anna Karin, additional, Zvonar, Martin, additional, Andryskova, Lenka, additional, Fabelova, Lucia, additional, Richterova, Denisa, additional, Horvat, Milena, additional, Kosjek, Tina, additional, Sarigiannis, Denis, additional, Maroulis, Marios, additional, Pedraza-Diaz, Susana, additional, Cañas, Ana, additional, Verheyen, Veerle J., additional, Bastiaensen, Michiel, additional, Gilles, Liese, additional, Schoeters, Greet, additional, Esteban-López, Marta, additional, Castaño, Argelia, additional, Govarts, Eva, additional, Koch, Holger M., additional, and Kolossa-Gehring, Marike, additional
Published: 2023
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21. Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014–2021)

Author: Govarts, Eva, primary, Gilles, Liese, additional, Rodriguez Martin, Laura, additional, Santonen, Tiina, additional, Apel, Petra, additional, Alvito, Paula, additional, Anastasi, Elena, additional, Andersen, Helle Raun, additional, Andersson, Anna-Maria, additional, Andryskova, Lenka, additional, Antignac, Jean-Philippe, additional, Appenzeller, Brice, additional, Barbone, Fabio, additional, Barnett-Itzhaki, Zohar, additional, Barouki, Robert, additional, Berman, Tamar, additional, Bil, Wieneke, additional, Borges, Teresa, additional, Buekers, Jurgen, additional, Cañas-Portilla, Ana, additional, Covaci, Adrian, additional, Csako, Zsofia, additional, Den Hond, Elly, additional, Dvorakova, Darina, additional, Fabelova, Lucia, additional, Fletcher, Tony, additional, Frederiksen, Hanne, additional, Gabriel, Catherine, additional, Ganzleben, Catherine, additional, Göen, Thomas, additional, Halldorsson, Thorhallur I., additional, Haug, Line S., additional, Horvat, Milena, additional, Huuskonen, Pasi, additional, Imboden, Medea, additional, Jagodic Hudobivnik, Marta, additional, Janasik, Beata, additional, Janev Holcer, Natasa, additional, Karakitsios, Spyros, additional, Katsonouri, Andromachi, additional, Klanova, Jana, additional, Kokaraki, Venetia, additional, Kold Jensen, Tina, additional, Koponen, Jani, additional, Laeremans, Michelle, additional, Laguzzi, Federica, additional, Lange, Rosa, additional, Lemke, Nora, additional, Lignell, Sanna, additional, Lindroos, Anna Karin, additional, Lobo Vicente, Joana, additional, Luijten, Mirjam, additional, Makris, Konstantinos C., additional, Mazej, Darja, additional, Melymuk, Lisa, additional, Meslin, Matthieu, additional, Mol, Hans, additional, Montazeri, Parisa, additional, Murawski, Aline, additional, Namorado, Sónia, additional, Niemann, Lars, additional, Nübler, Stefanie, additional, Nunes, Baltazar, additional, Olafsdottir, Kristin, additional, Palkovicova Murinova, Lubica, additional, Papaioannou, Nafsika, additional, Pedraza-Diaz, Susana, additional, Piler, Pavel, additional, Plichta, Veronika, additional, Poteser, Michael, additional, Probst-Hensch, Nicole, additional, Rambaud, Loïc, additional, Rauscher-Gabernig, Elke, additional, Rausova, Katarina, additional, Remy, Sylvie, additional, Riou, Margaux, additional, Rosolen, Valentina, additional, Rousselle, Christophe, additional, Rüther, Maria, additional, Sarigiannis, Denis, additional, Silva, Maria J., additional, Šlejkovec, Zdenka, additional, Snoj Tratnik, Janja, additional, Stajnko, Anja, additional, Szigeti, Tamas, additional, Tarazona, José V., additional, Thomsen, Cathrine, additional, Tkalec, Žiga, additional, Tolonen, Hanna, additional, Trnovec, Tomas, additional, Uhl, Maria, additional, Van Nieuwenhuyse, An, additional, Vasco, Elsa, additional, Verheyen, Veerle J., additional, Viegas, Susana, additional, Vinggaard, Anne Marie, additional, Vogel, Nina, additional, Vorkamp, Katrin, additional, Wasowicz, Wojciech, additional, Weber, Till, additional, Wimmerova, Sona, additional, Woutersen, Marjolijn, additional, Zimmermann, Philipp, additional, Zvonar, Martin, additional, Koch, Holger, additional, Kolossa-Gehring, Marike, additional, Esteban López, Marta, additional, Castaño, Argelia, additional, Stewart, Lorraine, additional, Sepai, Ovnair, additional, and Schoeters, Greet, additional
Published: 2023
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22. Exposure to Phthalates in European Children, Adolescents and Adults since 2005: A Harmonized Approach Based on Existing HBM Data in the HBM4EU Initiative

Author: Vogel, Nina, primary, Lange, Rosa, additional, Schmidt, Phillipp, additional, Rodriguez Martin, Laura, additional, Remy, Sylvie, additional, Springer, Andrea, additional, Puklová, Vladimíra, additional, Černá, Milena, additional, Rudnai, Péter, additional, Középesy, Szilvia, additional, Janasik, Beata, additional, Ligocka, Danuta, additional, Fábelová, Lucia, additional, Kolena, Branislav, additional, Petrovicova, Ida, additional, Jajcaj, Michal, additional, Eštóková, Milada, additional, Esteban-Lopez, Marta, additional, Castaño, Argelia, additional, Tratnik, Janja Snoj, additional, Stajnko, Anja, additional, Knudsen, Lisbeth E., additional, Toppari, Jorma, additional, Main, Katharina M., additional, Juul, Anders, additional, Andersson, Anna-Maria, additional, Jørgensen, Niels, additional, Frederiksen, Hanne, additional, Thomsen, Cathrine, additional, Sakhi, Amrit Kaur, additional, Åkesson, Agneta, additional, Hartmann, Christina, additional, Dewolf, Marie Christine, additional, Koppen, Gudrun, additional, Biot, Pierre, additional, Den Hond, Elly, additional, Voorspoels, Stefan, additional, Gilles, Liese, additional, Govarts, Eva, additional, Murawski, Aline, additional, Gerofke, Antje, additional, Weber, Till, additional, Rüther, Maria, additional, Gutleb, Arno C., additional, Guignard, Cedric, additional, Berman, Tamar, additional, Koch, Holger M., additional, and Kolossa-Gehring, Marike, additional
Published: 2023
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23. Human urinary arsenic species, associated exposure determinants and potential health risks assessed in the HBM4EU Aligned Studies

Author: Buekers, Jurgen, primary, Baken, Kirsten, additional, Govarts, Eva, additional, Martin, Laura Rodriguez, additional, Vogel, Nina, additional, Kolossa-Gehring, Marike, additional, Šlejkovec, Zdenka, additional, Falnoga, Ingrid, additional, Horvat, Milena, additional, Lignell, Sanna, additional, Lindroos, Anna Karin, additional, Rambaud, Loïc, additional, Riou, Margaux, additional, Pedraza-Diaz, Susana, additional, Esteban-Lopez, Marta, additional, Castaño, Argelia, additional, Den Hond, Elly, additional, Baeyens, Willy, additional, Santonen, Tiina, additional, and Schoeters, Greet, additional
Published: 2023
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24. From science to policy: How European HBM indicators help to answer policy questions related to phthalates and DINCH exposure

Author: Gerofke, Antje, David, Madlen, Schmidt, Phillipp, Vicente, Joana Lobo, Buekers, Jurgen, Gilles, Liese, Colles, Ann, Bessems, Jos, Bastiaensen, Michiel, Covaci, Adrian, Den Hond, Elly, Koppen, Gudrun, Laeremans, Michelle, Verheyen, Veerle J, Černá, Milena, Klánová, Jana, Krsková, Andrea, Zvonař, Martin, Knudsen, Lisbeth E, Koch, Holger M, Jensen, Tina Kold, Rambaud, Loïc, Riou, Margaux, Vogel, Nina, Gabriel, Catherine, Karakitsios, Spyros, Papaioannou, Nafsika, Sarigiannis, Denis, Kakucs, Réka, Középesy, Szilvia, Rudnai, Péter, Szigeti, Tamás, Barbone, Fabio, Rosolen, Valentina, Guignard, Cedric, Gutleb, Arno C, Sakhi, Amrit Kaur, Haug, Line Småstuen, Janasik, Beata, Ligocka, Danuta, Estokova, Milada, Fabelova, Lucia, Kolena, Branislav, Murinova, Lubica Palkovicova, Petrovicova, Ida, Richterova, Denisa, Horvat, Milena, Mazej, Darja, Tratnik, Janja Snoj, Runkel, Agneta Annika, Castaño, Argelia, Esteban-López, Marta, Pedraza-Díaz, Susana, Åkesson, Agneta, Lignell, Sanna, Vlaanderen, Jelle, Zock, Jan-Paul, Schoeters, Greet, Kolossa-Gehring, Marike, Gerofke, Antje, David, Madlen, Schmidt, Phillipp, Vicente, Joana Lobo, Buekers, Jurgen, Gilles, Liese, Colles, Ann, Bessems, Jos, Bastiaensen, Michiel, Covaci, Adrian, Den Hond, Elly, Koppen, Gudrun, Laeremans, Michelle, Verheyen, Veerle J, Černá, Milena, Klánová, Jana, Krsková, Andrea, Zvonař, Martin, Knudsen, Lisbeth E, Koch, Holger M, Jensen, Tina Kold, Rambaud, Loïc, Riou, Margaux, Vogel, Nina, Gabriel, Catherine, Karakitsios, Spyros, Papaioannou, Nafsika, Sarigiannis, Denis, Kakucs, Réka, Középesy, Szilvia, Rudnai, Péter, Szigeti, Tamás, Barbone, Fabio, Rosolen, Valentina, Guignard, Cedric, Gutleb, Arno C, Sakhi, Amrit Kaur, Haug, Line Småstuen, Janasik, Beata, Ligocka, Danuta, Estokova, Milada, Fabelova, Lucia, Kolena, Branislav, Murinova, Lubica Palkovicova, Petrovicova, Ida, Richterova, Denisa, Horvat, Milena, Mazej, Darja, Tratnik, Janja Snoj, Runkel, Agneta Annika, Castaño, Argelia, Esteban-López, Marta, Pedraza-Díaz, Susana, Åkesson, Agneta, Lignell, Sanna, Vlaanderen, Jelle, Zock, Jan-Paul, Schoeters, Greet, and Kolossa-Gehring, Marike
Abstract: Within the European Human Biomonitoring (HBM) Initiative HBM4EU we derived HBM indicators that were designed to help answering key policy questions and support chemical policies. The result indicators convey information on chemicals exposure of different age groups, sexes, geographical regions and time points by comparing median exposure values. If differences are observed for one group or the other, policy measures or risk management options can be implemented. Impact indicators support health risk assessment by comparing exposure values with health-based guidance values, such as human biomonitoring guidance values (HBM-GVs). In general, the indicators should be designed to translate complex scientific information into short and clear messages and make it accessible to policy makers but also to a broader audience such as stakeholders (e.g. NGO's), other scientists and the general public. Based on harmonized data from the HBM4EU Aligned Studies (2014-2021), the usefulness of our indicators was demonstrated for the age group children (6-11 years), using two case examples: one phthalate (Diisobutyl phthalate: DiBP) and one non-phthalate substitute (Di-isononyl cyclohexane-1,2- dicarboxylate: DINCH). For the comparison of age groups, these were compared to data for teenagers (12-18 years), and time periods were compared using data from the DEMOCOPHES project (2011-2012). Our result indicators proved to be suitable for demonstrating the effectiveness of policy measures for DiBP and the need of continuous monitoring for DINCH. They showed similar exposure for boys and girls, indicating that there is no need for gender focused interventions and/or no indication of sex-specific exposure patterns. They created a basis for a targeted approach by highlighting relevant geographical differences in internal exposure. An adequate data basis is essential for revealing differences for all indicators. This was particularly evident in our studies on the indicators on age differenc
Published: 2023

25. From science to policy: How European HBM indicators help to answer policy questions related to phthalates and DINCH exposure

Author: IRAS OH Epidemiology Chemical Agents, Gerofke, Antje, David, Madlen, Schmidt, Phillipp, Vicente, Joana Lobo, Buekers, Jurgen, Gilles, Liese, Colles, Ann, Bessems, Jos, Bastiaensen, Michiel, Covaci, Adrian, Den Hond, Elly, Koppen, Gudrun, Laeremans, Michelle, Verheyen, Veerle J, Černá, Milena, Klánová, Jana, Krsková, Andrea, Zvonař, Martin, Knudsen, Lisbeth E, Koch, Holger M, Jensen, Tina Kold, Rambaud, Loïc, Riou, Margaux, Vogel, Nina, Gabriel, Catherine, Karakitsios, Spyros, Papaioannou, Nafsika, Sarigiannis, Denis, Kakucs, Réka, Középesy, Szilvia, Rudnai, Péter, Szigeti, Tamás, Barbone, Fabio, Rosolen, Valentina, Guignard, Cedric, Gutleb, Arno C, Sakhi, Amrit Kaur, Haug, Line Småstuen, Janasik, Beata, Ligocka, Danuta, Estokova, Milada, Fabelova, Lucia, Kolena, Branislav, Murinova, Lubica Palkovicova, Petrovicova, Ida, Richterova, Denisa, Horvat, Milena, Mazej, Darja, Tratnik, Janja Snoj, Runkel, Agneta Annika, Castaño, Argelia, Esteban-López, Marta, Pedraza-Díaz, Susana, Åkesson, Agneta, Lignell, Sanna, Vlaanderen, Jelle, Zock, Jan-Paul, Schoeters, Greet, Kolossa-Gehring, Marike, IRAS OH Epidemiology Chemical Agents, Gerofke, Antje, David, Madlen, Schmidt, Phillipp, Vicente, Joana Lobo, Buekers, Jurgen, Gilles, Liese, Colles, Ann, Bessems, Jos, Bastiaensen, Michiel, Covaci, Adrian, Den Hond, Elly, Koppen, Gudrun, Laeremans, Michelle, Verheyen, Veerle J, Černá, Milena, Klánová, Jana, Krsková, Andrea, Zvonař, Martin, Knudsen, Lisbeth E, Koch, Holger M, Jensen, Tina Kold, Rambaud, Loïc, Riou, Margaux, Vogel, Nina, Gabriel, Catherine, Karakitsios, Spyros, Papaioannou, Nafsika, Sarigiannis, Denis, Kakucs, Réka, Középesy, Szilvia, Rudnai, Péter, Szigeti, Tamás, Barbone, Fabio, Rosolen, Valentina, Guignard, Cedric, Gutleb, Arno C, Sakhi, Amrit Kaur, Haug, Line Småstuen, Janasik, Beata, Ligocka, Danuta, Estokova, Milada, Fabelova, Lucia, Kolena, Branislav, Murinova, Lubica Palkovicova, Petrovicova, Ida, Richterova, Denisa, Horvat, Milena, Mazej, Darja, Tratnik, Janja Snoj, Runkel, Agneta Annika, Castaño, Argelia, Esteban-López, Marta, Pedraza-Díaz, Susana, Åkesson, Agneta, Lignell, Sanna, Vlaanderen, Jelle, Zock, Jan-Paul, Schoeters, Greet, and Kolossa-Gehring, Marike
Published: 2023

26. Harmonized human biomonitoring in European children, teenagers and adults:EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014-2021)

Author: Govarts, Eva, Gilles, Liese, Rodriguez Martin, Laura, Santonen, Tiina, Apel, Petra, Alvito, Paula, Anastasi, Elena, Andersen, Helle Raun, Andersson, Anna-Maria, Andryskova, Lenka, Antignac, Jean-Philippe, Appenzeller, Brice, Barbone, Fabio, Barnett-Itzhaki, Zohar, Barouki, Robert, Berman, Tamar, Bil, Wieneke, Borges, Teresa, Buekers, Jurgen, Cañas-Portilla, Ana, Covaci, Adrian, Csako, Zsofia, Den Hond, Elly, Dvorakova, Darina, Fabelova, Lucia, Fletcher, Tony, Frederiksen, Hanne, Gabriel, Catherine, Ganzleben, Catherine, Göen, Thomas, Halldorsson, Thorhallur I, Haug, Line S, Horvat, Milena, Huuskonen, Pasi, Imboden, Medea, Jagodic Hudobivnik, Marta, Janasik, Beata, Janev Holcer, Natasa, Karakitsios, Spyros, Katsonouri, Andromachi, Klanova, Jana, Kokaraki, Venetia, Kold Jensen, Tina, Koponen, Jani, Laeremans, Michelle, Laguzzi, Federica, Lange, Rosa, Lemke, Nora, Lignell, Sanna, Lindroos, Anna Karin, Lobo Vicente, Joana, Luijten, Mirjam, Makris, Konstantinos C, Mazej, Darja, Melymuk, Lisa, Meslin, Matthieu, Mol, Hans, Montazeri, Parisa, Murawski, Aline, Namorado, Sónia, Niemann, Lars, Nübler, Stefanie, Nunes, Baltazar, Olafsdottir, Kristin, Palkovicova Murinova, Lubica, Papaioannou, Nafsika, Pedraza-Diaz, Susana, Piler, Pavel, Plichta, Veronika, Poteser, Michael, Probst-Hensch, Nicole, Rambaud, Loïc, Rauscher-Gabernig, Elke, Rausova, Katarina, Remy, Sylvie, Riou, Margaux, Rosolen, Valentina, Rousselle, Christophe, Rüther, Maria, Sarigiannis, Denis, Silva, Maria J., Šlejkovec, Zdenka, Snoj Tratnik, Janja, Stajnko, Anja, Szigeti, Tamas, Tarazona, José V., Thomsen, Cathrine, Tkalec, Žiga, Tolonen, Hanna, Trnovec, Tomas, Uhl, Maria, Van Nieuwenhuyse, An, Vasco, Elsa, Verheyen, Veerle J, Viegas, Susana, Vinggaard, Anne Marie, Vogel, Nina, Vorkamp, Katrin, Wasowicz, Wojciech, Weber, Till, Wimmerova, Sona, Woutersen, Marjolijn, Zimmermann, Philipp, Zvonar, Martin, Koch, Holger, Kolossa-Gehring, Marike, Esteban López, Marta, Castaño, Argelia, Stewart, Lorraine, Sepai, Ovnair, Schoeters, Greet, Govarts, Eva, Gilles, Liese, Rodriguez Martin, Laura, Santonen, Tiina, Apel, Petra, Alvito, Paula, Anastasi, Elena, Andersen, Helle Raun, Andersson, Anna-Maria, Andryskova, Lenka, Antignac, Jean-Philippe, Appenzeller, Brice, Barbone, Fabio, Barnett-Itzhaki, Zohar, Barouki, Robert, Berman, Tamar, Bil, Wieneke, Borges, Teresa, Buekers, Jurgen, Cañas-Portilla, Ana, Covaci, Adrian, Csako, Zsofia, Den Hond, Elly, Dvorakova, Darina, Fabelova, Lucia, Fletcher, Tony, Frederiksen, Hanne, Gabriel, Catherine, Ganzleben, Catherine, Göen, Thomas, Halldorsson, Thorhallur I, Haug, Line S, Horvat, Milena, Huuskonen, Pasi, Imboden, Medea, Jagodic Hudobivnik, Marta, Janasik, Beata, Janev Holcer, Natasa, Karakitsios, Spyros, Katsonouri, Andromachi, Klanova, Jana, Kokaraki, Venetia, Kold Jensen, Tina, Koponen, Jani, Laeremans, Michelle, Laguzzi, Federica, Lange, Rosa, Lemke, Nora, Lignell, Sanna, Lindroos, Anna Karin, Lobo Vicente, Joana, Luijten, Mirjam, Makris, Konstantinos C, Mazej, Darja, Melymuk, Lisa, Meslin, Matthieu, Mol, Hans, Montazeri, Parisa, Murawski, Aline, Namorado, Sónia, Niemann, Lars, Nübler, Stefanie, Nunes, Baltazar, Olafsdottir, Kristin, Palkovicova Murinova, Lubica, Papaioannou, Nafsika, Pedraza-Diaz, Susana, Piler, Pavel, Plichta, Veronika, Poteser, Michael, Probst-Hensch, Nicole, Rambaud, Loïc, Rauscher-Gabernig, Elke, Rausova, Katarina, Remy, Sylvie, Riou, Margaux, Rosolen, Valentina, Rousselle, Christophe, Rüther, Maria, Sarigiannis, Denis, Silva, Maria J., Šlejkovec, Zdenka, Snoj Tratnik, Janja, Stajnko, Anja, Szigeti, Tamas, Tarazona, José V., Thomsen, Cathrine, Tkalec, Žiga, Tolonen, Hanna, Trnovec, Tomas, Uhl, Maria, Van Nieuwenhuyse, An, Vasco, Elsa, Verheyen, Veerle J, Viegas, Susana, Vinggaard, Anne Marie, Vogel, Nina, Vorkamp, Katrin, Wasowicz, Wojciech, Weber, Till, Wimmerova, Sona, Woutersen, Marjolijn, Zimmermann, Philipp, Zvonar, Martin, Koch, Holger, Kolossa-Gehring, Marike, Esteban López, Marta, Castaño, Argelia, Stewart, Lorraine, Sepai, Ovnair, and Schoeters, Greet
Abstract: As one of the core elements of the European Human Biomonitoring Initiative (HBM4EU) a human biomonitoring (HBM) survey was conducted in 23 countries to generate EU-wide comparable HBM data. This survey has built on existing HBM capacity in Europe by aligning national or regional HBM studies, referred to as the HBM4EU Aligned Studies. The HBM4EU Aligned Studies included a total of 10,795 participants of three age groups: (i) 3,576 children aged 6-12 years, (ii) 3,117 teenagers aged 12-18 years and (iii) 4,102 young adults aged 20-39 years. The participants were recruited between 2014 and 2021 in 11-12 countries per age group, geographically distributed across Europe. Depending on the age group, internal exposure to phthalates and the substitute DINCH, halogenated and organophosphorus flame retardants, per- and polyfluoroalkyl substances (PFASs), cadmium, bisphenols, polycyclic aromatic hydrocarbons (PAHs), arsenic species, acrylamide, mycotoxins (deoxynivalenol (total DON)), benzophenones and selected pesticides was assessed by measuring substance specific biomarkers subjected to stringent quality control programs for chemical analysis. For substance groups analyzed in different age groups higher average exposure levels were observed in the youngest age group, i.e., phthalates/DINCH in children versus teenagers, acrylamide and pesticides in children versus adults, benzophenones in teenagers versus adults. Many biomarkers in teenagers and adults varied significantly according to educational attainment, with higher exposure levels of bisphenols, phthalates, benzophenones, PAHs and acrylamide in participants (from households) with lower educational attainment, while teenagers from households with higher educational attainment have higher exposure levels for PFASs and arsenic. In children, a social gradient was only observed for the non-specific pyrethroid metabolite 3-PBA and di-isodecyl phthalate (DiDP), with higher levels in children from households with higher educat
Published: 2023

27. Time Patterns in Internal Human Exposure Data to Bisphenols, Phthalates, DINCH, Organophosphate Flame Retardants, Cadmium and Polyaromatic Hydrocarbons in Europe

Author: Rodriguez Martin, Laura, Gilles, Liese, Helte, Emilie, Åkesson, Agneta, Tägt, Jonas, Covaci, Adrian, Sakhi, Amrit K., Van Nieuwenhuyse, An, Katsonouri, Andromachi, Andersson, Anna Maria, Gutleb, Arno C., Janasik, Beata, Appenzeller, Brice, Gabriel, Catherine, Thomsen, Cathrine, Mazej, Darja, Sarigiannis, Denis, Anastasi, Elena, Barbone, Fabio, Tolonen, Hanna, Frederiksen, Hanne, Klanova, Jana, Koponen, Jani, Tratnik, Janja Snoj, Pack, Kim, Gudrun, Koppen, Ólafsdóttir, Kristin, Knudsen, Lisbeth E., Rambaud, Loïc, Strumylaite, Loreta, Murinova, Lubica Palkovicova, Fabelova, Lucia, Riou, Margaux, Berglund, Marika, Szabados, Maté, Imboden, Medea, Laeremans, Michelle, Eštóková, Milada, Janev Holcer, Natasa, Probst-Hensch, Nicole, Vodrazkova, Nicole, Vogel, Nina, Piler, Pavel, Schmidt, Phillipp, Lange, Rosa, Namorado, Sónia, Kozepesy, Szilvia, Szigeti, Tamás, Halldorsson, Thorhallur I., Weber, Till, Jensen, Tina Kold, Rosolen, Valentina, Puklova, Vladimira, Wasowicz, Wojciech, Sepai, Ovnair, Stewart, Lorraine, Kolossa-Gehring, Marike, Esteban-López, Marta, Castaño, Argelia, Bessems, Jos, Schoeters, Greet, Govarts, Eva, Rodriguez Martin, Laura, Gilles, Liese, Helte, Emilie, Åkesson, Agneta, Tägt, Jonas, Covaci, Adrian, Sakhi, Amrit K., Van Nieuwenhuyse, An, Katsonouri, Andromachi, Andersson, Anna Maria, Gutleb, Arno C., Janasik, Beata, Appenzeller, Brice, Gabriel, Catherine, Thomsen, Cathrine, Mazej, Darja, Sarigiannis, Denis, Anastasi, Elena, Barbone, Fabio, Tolonen, Hanna, Frederiksen, Hanne, Klanova, Jana, Koponen, Jani, Tratnik, Janja Snoj, Pack, Kim, Gudrun, Koppen, Ólafsdóttir, Kristin, Knudsen, Lisbeth E., Rambaud, Loïc, Strumylaite, Loreta, Murinova, Lubica Palkovicova, Fabelova, Lucia, Riou, Margaux, Berglund, Marika, Szabados, Maté, Imboden, Medea, Laeremans, Michelle, Eštóková, Milada, Janev Holcer, Natasa, Probst-Hensch, Nicole, Vodrazkova, Nicole, Vogel, Nina, Piler, Pavel, Schmidt, Phillipp, Lange, Rosa, Namorado, Sónia, Kozepesy, Szilvia, Szigeti, Tamás, Halldorsson, Thorhallur I., Weber, Till, Jensen, Tina Kold, Rosolen, Valentina, Puklova, Vladimira, Wasowicz, Wojciech, Sepai, Ovnair, Stewart, Lorraine, Kolossa-Gehring, Marike, Esteban-López, Marta, Castaño, Argelia, Bessems, Jos, Schoeters, Greet, and Govarts, Eva
Abstract: Human biomonitoring (HBM) data in Europe are often fragmented and collected in different EU countries and sampling periods. Exposure levels for children and adult women in Europe were evaluated over time. For the period 2000–2010, literature and aggregated data were collected in a harmonized way across studies. Between 2011–2012, biobanked samples from the DEMOCOPHES project were used. For 2014–2021, HBM data were generated within the HBM4EU Aligned Studies. Time patterns on internal exposure were evaluated visually and statistically using the 50th and 90th percentiles (P50/P90) for phthalates/DINCH and organophosphorus flame retardants (OPFRs) in children (5–12 years), and cadmium, bisphenols and polycyclic aromatic hydrocarbons (PAHs) in women (24–52 years). Restricted phthalate metabolites show decreasing patterns for children. Phthalate substitute, DINCH, shows a non-significant increasing pattern. For OPFRs, no trends were statistically significant. For women, BPA shows a clear decreasing pattern, while substitutes BPF and BPS show an increasing pattern coinciding with the BPA restrictions introduced. No clear patterns are observed for PAHs or cadmium. Although the causal relations were not studied as such, exposure levels to chemicals restricted at EU level visually decreased, while the levels for some of their substitutes increased. The results support policy efficacy monitoring and the policy-supportive role played by HBM. Keywords: human biomonitoring; hazardous chemical; phthalates; DINCH; OPFRs; cadmium; PAHs; bisphenols, Human biomonitoring (HBM) data in Europe are often fragmented and collected in different EU countries and sampling periods. Exposure levels for children and adult women in Europe were evaluated over time. For the period 2000–2010, literature and aggregated data were collected in a harmonized way across studies. Between 2011–2012, biobanked samples from the DEMOCOPHES project were used. For 2014–2021, HBM data were generated within the HBM4EU Aligned Studies. Time patterns on internal exposure were evaluated visually and statistically using the 50th and 90th percentiles (P50/P90) for phthalates/DINCH and organophosphorus flame retardants (OPFRs) in children (5–12 years), and cadmium, bisphenols and polycyclic aromatic hydrocarbons (PAHs) in women (24–52 years). Restricted phthalate metabolites show decreasing patterns for children. Phthalate substitute, DINCH, shows a non-significant increasing pattern. For OPFRs, no trends were statistically significant. For women, BPA shows a clear decreasing pattern, while substitutes BPF and BPS show an increasing pattern coinciding with the BPA restrictions introduced. No clear patterns are observed for PAHs or cadmium. Although the causal relations were not studied as such, exposure levels to chemicals restricted at EU level visually decreased, while the levels for some of their substitutes increased. The results support policy efficacy monitoring and the policy-supportive role played by HBM.
Published: 2023

28. Coordination of chemical analyses under the European Human Biomonitoring Initiative (HBM4EU):Concepts, procedures and lessons learnt

Author: Vorkamp, Katrin, Esteban López, Marta, Gilles, Liese, Göen, Thomas, Govarts, Eva, Hajeb, Parvaneh, Katsonouri, Andromachi, Knudsen, Lisbeth E., Kolossa-Gehring, Marike, Lindh, Christian, Nübler, Stefanie, Pedraza-Díaz, Susana, Santonen, Tiina, Castaño, Argelia, Vorkamp, Katrin, Esteban López, Marta, Gilles, Liese, Göen, Thomas, Govarts, Eva, Hajeb, Parvaneh, Katsonouri, Andromachi, Knudsen, Lisbeth E., Kolossa-Gehring, Marike, Lindh, Christian, Nübler, Stefanie, Pedraza-Díaz, Susana, Santonen, Tiina, and Castaño, Argelia
Abstract: The European Human Biomonitoring Initiative (HBM4EU) ran from 2017 to 2022 with the aim of advancing and harmonizing human biomonitoring in Europe. More than 40,000 analyses were performed on human samples in different human biomonitoring studies in HBM4EU, addressing the chemical exposure of the general population, temporal developments, occupational exposure and a public health intervention on mercury in populations with high fish consumption. The analyses covered 15 priority groups of organic chemicals and metals and were carried out by a network of laboratories meeting the requirements of a comprehensive quality assurance and control system. The coordination of the chemical analyses included establishing contacts between sample owners and qualified laboratories and monitoring the progress of the chemical analyses during the analytical phase, also addressing status and consequences of Covid-19 measures. Other challenges were related to the novelty and complexity of HBM4EU, including administrative and financial matters and implementation of standardized procedures. Many individual contacts were necessary in the initial phase of HBM4EU. However, there is a potential to develop more streamlined and standardized communication and coordination in the analytical phase of a consolidated European HBM programme.
Published: 2023

29. Application of human biomonitoring data to support policy development, raise awareness and environmental public health protection among countries within the HBM4EU project

Author: Ubong, Dorothy, Stewart, Lorraine, Sepai, Ovnair, Knudsen, Lisbeth E., Berman, Tamar, Reynders, Hans, Van Campenhout, Karen, Katsonouri, Andromachi, Van Nieuwenhuyse, An, Ingelido, Anna Maria, Castaño, Argelia, Pedraza-Díaz, Susana, Eiríksdóttir, Ása Valgerður, Thomsen, Cathrine, Hartmann, Christina, Gjorgjev, Dragan, De Felip, Elena, Tolonen, Hanna, Santonen, Tiina, klanova, Jana, Norström, Karin, Kononenko, Lijana, Silva, Maria João, Uhl, Maria, Kolossa-Gehring, Marike, Apel, Petra, Jõemaa, Merli, Jajcaj, Michal, Estokova, Milada, Luijten, Mirjam, Lebret, Erik, von Goetz, Natalie, Holcer, Natasa Janev, Probst-Hensch, Nicole, Cavaleiro, Rita, Barouki, Robert, Tarroja, Elena, Balčienė, Rosita Marija, Strumylaite, Loreta, Latvala, Siiri, Namorado, Sónia, Szigeti, Tamás, Ingi Halldorsson, Thorhallur, Olafsdottir, Kristin, Wasowicz, Wojciech, Viegas, Susana, Alvito, Paula, Ubong, Dorothy, Stewart, Lorraine, Sepai, Ovnair, Knudsen, Lisbeth E., Berman, Tamar, Reynders, Hans, Van Campenhout, Karen, Katsonouri, Andromachi, Van Nieuwenhuyse, An, Ingelido, Anna Maria, Castaño, Argelia, Pedraza-Díaz, Susana, Eiríksdóttir, Ása Valgerður, Thomsen, Cathrine, Hartmann, Christina, Gjorgjev, Dragan, De Felip, Elena, Tolonen, Hanna, Santonen, Tiina, klanova, Jana, Norström, Karin, Kononenko, Lijana, Silva, Maria João, Uhl, Maria, Kolossa-Gehring, Marike, Apel, Petra, Jõemaa, Merli, Jajcaj, Michal, Estokova, Milada, Luijten, Mirjam, Lebret, Erik, von Goetz, Natalie, Holcer, Natasa Janev, Probst-Hensch, Nicole, Cavaleiro, Rita, Barouki, Robert, Tarroja, Elena, Balčienė, Rosita Marija, Strumylaite, Loreta, Latvala, Siiri, Namorado, Sónia, Szigeti, Tamás, Ingi Halldorsson, Thorhallur, Olafsdottir, Kristin, Wasowicz, Wojciech, Viegas, Susana, and Alvito, Paula
Abstract: Most countries have acknowledged the importance of assessing and quantifying their population's internal exposure from chemicals in air, water, soil, food and other consumer products due to the potential health and economic impact. Human biomonitoring (HBM) is a valuable tool which can be used to quantify such exposures and effects. Results from HBM studies can also contribute to improving public health by providing evidence of individuals' internal chemical exposure as well as data to understand the burden of disease and associated costs thereby stimulating the development and implementation of evidence-based policy. To have a holistic view on HBM data utilisation, a multi-case research approach was used to explore the use of HBM data to support national chemical regulations, protect public health and raise awareness among countries participating in the HBM4EU project. The Human Biomonitoring for Europe (HBM4EU) Initiative (https://www.hbm4eu.eu/) is a collaborative effort involving 30 countries, the European Environment Agency (EEA) and the European Commission (contracting authority) to harmonise procedures across Europe and advance research into the understanding of the health impacts of environmental chemical exposure. One of the aims of the project was to use HBM data to support evidence based chemical policy and make this information timely and directly available for policy makers and all partners. The main data source for this article was the narratives collected from 27 countries within the HBM4EU project. The countries (self-selection) were grouped into 3 categories in terms of HBM data usage either for public awareness, policy support or for the establishment HBM programme. Narratives were analysed/summarised using guidelines and templates that focused on ministries involved in or advocating for HBM; steps required to engage policy makers; barriers, drivers and opportunities in developing a HBM programme. The narratives reported the use of HBM data eith
Published: 2023

30. Exposure to Phthalates in European Children, Adolescents and Adults since 2005:A Harmonized Approach Based on Existing HBM Data in the HBM4EU Initiative

Author: Vogel, Nina, Lange, Rosa, Schmidt, Phillipp, Rodriguez Martin, Laura, Remy, Sylvie, Springer, Andrea, Puklová, Vladimíra, Černá, Milena, Rudnai, Péter, Középesy, Szilvia, Janasik, Beata, Ligocka, Danuta, Fábelová, Lucia, Kolena, Branislav, Petrovicova, Ida, Jajcaj, Michal, Eštóková, Milada, Esteban-Lopez, Marta, Castaño, Argelia, Tratnik, Janja Snoj, Stajnko, Anja, Knudsen, Lisbeth E., Toppari, Jorma, Main, Katharina M., Juul, Anders, Andersson, Anna Maria, Jørgensen, Niels, Frederiksen, Hanne, Thomsen, Cathrine, Sakhi, Amrit Kaur, Åkesson, Agneta, Hartmann, Christina, Dewolf, Marie Christine, Koppen, Gudrun, Biot, Pierre, Den Hond, Elly, Voorspoels, Stefan, Gilles, Liese, Govarts, Eva, Murawski, Aline, Gerofke, Antje, Weber, Till, Rüther, Maria, Gutleb, Arno C., Guignard, Cedric, Berman, Tamar, Koch, Holger M., Kolossa-Gehring, Marike, Vogel, Nina, Lange, Rosa, Schmidt, Phillipp, Rodriguez Martin, Laura, Remy, Sylvie, Springer, Andrea, Puklová, Vladimíra, Černá, Milena, Rudnai, Péter, Középesy, Szilvia, Janasik, Beata, Ligocka, Danuta, Fábelová, Lucia, Kolena, Branislav, Petrovicova, Ida, Jajcaj, Michal, Eštóková, Milada, Esteban-Lopez, Marta, Castaño, Argelia, Tratnik, Janja Snoj, Stajnko, Anja, Knudsen, Lisbeth E., Toppari, Jorma, Main, Katharina M., Juul, Anders, Andersson, Anna Maria, Jørgensen, Niels, Frederiksen, Hanne, Thomsen, Cathrine, Sakhi, Amrit Kaur, Åkesson, Agneta, Hartmann, Christina, Dewolf, Marie Christine, Koppen, Gudrun, Biot, Pierre, Den Hond, Elly, Voorspoels, Stefan, Gilles, Liese, Govarts, Eva, Murawski, Aline, Gerofke, Antje, Weber, Till, Rüther, Maria, Gutleb, Arno C., Guignard, Cedric, Berman, Tamar, Koch, Holger M., and Kolossa-Gehring, Marike
Abstract: Phthalates are mainly used as plasticizers and are associated inter alia with adverse effects on reproductive functions. While more and more national programs in Europe have started monitoring internal exposure to phthalates and its substitute 1,2-Cyclohexanedicarboxylic acid (DINCH), the comparability of results from such existing human biomonitoring (HBM) studies across Europe is challenging. They differ widely in time periods, study samples, degree of geographical coverage, design, analytical methodology, biomarker selection, and analytical quality assurance level. The HBM4EU initiative has gathered existing HBM data of 29 studies from participating countries, covering all European regions and Israel. The data were prepared and aggregated by a harmonized procedure with the aim to describe—as comparably as possible—the EU-wide general population’s internal exposure to phthalates from the years 2005 to 2019. Most data were available from Northern (up to 6 studies and up to 13 time points), Western (11; 19), and Eastern Europe (9; 12), e.g., allowing for the investigation of time patterns. While the bandwidth of exposure was generally similar, we still observed regional differences for Butyl benzyl phthalate (BBzP), Di(2-ethylhexyl) phthalate (DEHP), Di-isononyl phthalate (DiNP), and Di-isobutyl phthalate (DiBP) with pronounced decreases over time in Northern and Western Europe, and to a lesser degree in Eastern Europe. Differences between age groups were visible for Di-n-butyl phthalate (DnBP), where children (3 to 5-year olds and 6 to 11-year olds) had lower urinary concentrations than adolescents (12 to 19-year-olds), who in turn had lower urinary concentrations than adults (20 to 39-year-olds). This study is a step towards making internal exposures to phthalates comparable across countries, although standardized data were not available, targeting European data sets harmonized with respect to data formatting and calculation of aggregated data (such as develope
Published: 2023

31. From science to policy:How European HBM indicators help to answer policy questions related to phthalates and DINCH exposure

Author: Gerofke, Antje, David, Madlen, Schmidt, Phillipp, Vicente, Joana Lobo, Buekers, Jurgen, Gilles, Liese, Colles, Ann, Bessems, Jos, Bastiaensen, Michiel, Covaci, Adrian, Den Hond, Elly, Koppen, Gudrun, Laeremans, Michelle, Verheyen, Veerle J., Černá, Milena, Klánová, Jana, Krsková, Andrea, Zvonař, Martin, Knudsen, Lisbeth E., Koch, Holger M., Jensen, Tina Kold, Rambaud, Loïc, Riou, Margaux, Vogel, Nina, Gabriel, Catherine, Karakitsios, Spyros, Papaioannou, Nafsika, Sarigiannis, Denis, Kakucs, Réka, Középesy, Szilvia, Rudnai, Péter, Szigeti, Tamás, Barbone, Fabio, Rosolen, Valentina, Guignard, Cedric, Gutleb, Arno C., Sakhi, Amrit Kaur, Haug, Line Småstuen, Janasik, Beata, Ligocka, Danuta, Estokova, Milada, Fabelova, Lucia, Kolena, Branislav, Murinova, Lubica Palkovicova, Petrovicova, Ida, Richterova, Denisa, Horvat, Milena, Mazej, Darja, Tratnik, Janja Snoj, Runkel, Agneta Annika, Castaño, Argelia, Esteban-López, Marta, Pedraza-Díaz, Susana, Åkesson, Agneta, Lignell, Sanna, Vlaanderen, Jelle, Zock, Jan Paul, Schoeters, Greet, Kolossa-Gehring, Marike, Gerofke, Antje, David, Madlen, Schmidt, Phillipp, Vicente, Joana Lobo, Buekers, Jurgen, Gilles, Liese, Colles, Ann, Bessems, Jos, Bastiaensen, Michiel, Covaci, Adrian, Den Hond, Elly, Koppen, Gudrun, Laeremans, Michelle, Verheyen, Veerle J., Černá, Milena, Klánová, Jana, Krsková, Andrea, Zvonař, Martin, Knudsen, Lisbeth E., Koch, Holger M., Jensen, Tina Kold, Rambaud, Loïc, Riou, Margaux, Vogel, Nina, Gabriel, Catherine, Karakitsios, Spyros, Papaioannou, Nafsika, Sarigiannis, Denis, Kakucs, Réka, Középesy, Szilvia, Rudnai, Péter, Szigeti, Tamás, Barbone, Fabio, Rosolen, Valentina, Guignard, Cedric, Gutleb, Arno C., Sakhi, Amrit Kaur, Haug, Line Småstuen, Janasik, Beata, Ligocka, Danuta, Estokova, Milada, Fabelova, Lucia, Kolena, Branislav, Murinova, Lubica Palkovicova, Petrovicova, Ida, Richterova, Denisa, Horvat, Milena, Mazej, Darja, Tratnik, Janja Snoj, Runkel, Agneta Annika, Castaño, Argelia, Esteban-López, Marta, Pedraza-Díaz, Susana, Åkesson, Agneta, Lignell, Sanna, Vlaanderen, Jelle, Zock, Jan Paul, Schoeters, Greet, and Kolossa-Gehring, Marike
Abstract: Within the European Human Biomonitoring (HBM) Initiative HBM4EU we derived HBM indicators that were designed to help answering key policy questions and support chemical policies. The result indicators convey information on chemicals exposure of different age groups, sexes, geographical regions and time points by comparing median exposure values. If differences are observed for one group or the other, policy measures or risk management options can be implemented. Impact indicators support health risk assessment by comparing exposure values with health-based guidance values, such as human biomonitoring guidance values (HBM-GVs). In general, the indicators should be designed to translate complex scientific information into short and clear messages and make it accessible to policy makers but also to a broader audience such as stakeholders (e.g. NGO's), other scientists and the general public. Based on harmonized data from the HBM4EU Aligned Studies (2014–2021), the usefulness of our indicators was demonstrated for the age group children (6–11 years), using two case examples: one phthalate (Diisobutyl phthalate: DiBP) and one non-phthalate substitute (Di-isononyl cyclohexane-1,2- dicarboxylate: DINCH). For the comparison of age groups, these were compared to data for teenagers (12–18 years), and time periods were compared using data from the DEMOCOPHES project (2011–2012). Our result indicators proved to be suitable for demonstrating the effectiveness of policy measures for DiBP and the need of continuous monitoring for DINCH. They showed similar exposure for boys and girls, indicating that there is no need for gender focused interventions and/or no indication of sex-specific exposure patterns. They created a basis for a targeted approach by highlighting relevant geographical differences in internal exposure. An adequate data basis is essential for revealing differences for all indicators. This was particularly evident in our studies on the indicators on age differences., Within the European Human Biomonitoring (HBM) Initiative HBM4EU we derived HBM indicators that were designed to help answering key policy questions and support chemical policies. The result indicators convey information on chemicals exposure of different age groups, sexes, geographical regions and time points by comparing median exposure values. If differences are observed for one group or the other, policy measures or risk management options can be implemented. Impact indicators support health risk assessment by comparing exposure values with health-based guidance values, such as human biomonitoring guidance values (HBM-GVs). In general, the indicators should be designed to translate complex scientific information into short and clear messages and make it accessible to policy makers but also to a broader audience such as stakeholders (e.g. NGO's), other scientists and the general public. Based on harmonized data from the HBM4EU Aligned Studies (2014–2021), the usefulness of our indicators was demonstrated for the age group children (6–11 years), using two case examples: one phthalate (Diisobutyl phthalate: DiBP) and one non-phthalate substitute (Di-isononyl cyclohexane-1,2- dicarboxylate: DINCH). For the comparison of age groups, these were compared to data for teenagers (12–18 years), and time periods were compared using data from the DEMOCOPHES project (2011–2012). Our result indicators proved to be suitable for demonstrating the effectiveness of policy measures for DiBP and the need of continuous monitoring for DINCH. They showed similar exposure for boys and girls, indicating that there is no need for gender focused interventions and/or no indication of sex-specific exposure patterns. They created a basis for a targeted approach by highlighting relevant geographical differences in internal exposure. An adequate data basis is essential for revealing differences for all indicators. This was particularly evident in our studies on the indicators on age differenc
Published: 2023

32. Harmonized human biomonitoring in European children, teenagers and adults : EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014–2021)

Author: Govarts, Eva, Gilles, Liese, Rodriguez Martin, Laura, Santonen, Tiina, Apel, Petra, Alvito, Paula, Anastasi, Elena, Andersen, Helle Raun, Andersson, Anna Maria, Andryskova, Lenka, Antignac, Jean Philippe, Appenzeller, Brice, Barbone, Fabio, Barnett-Itzhaki, Zohar, Barouki, Robert, Berman, Tamar, Bil, Wieneke, Borges, Teresa, Buekers, Jurgen, Cañas-Portilla, Ana, Covaci, Adrian, Csako, Zsofia, Den Hond, Elly, Dvorakova, Darina, Fabelova, Lucia, Fletcher, Tony, Frederiksen, Hanne, Gabriel, Catherine, Ganzleben, Catherine, Göen, Thomas, Halldorsson, Thorhallur I., Haug, Line S., Horvat, Milena, Huuskonen, Pasi, Imboden, Medea, Jagodic Hudobivnik, Marta, Janasik, Beata, Janev Holcer, Natasa, Karakitsios, Spyros, Katsonouri, Andromachi, Klanova, Jana, Kokaraki, Venetia, Kold Jensen, Tina, Koponen, Jani, Laeremans, Michelle, Laguzzi, Federica, Lange, Rosa, Lemke, Nora, Lignell, Sanna, Lindroos, Anna Karin, Lobo Vicente, Joana, Luijten, Mirjam, Makris, Konstantinos C., Mazej, Darja, Melymuk, Lisa, Meslin, Matthieu, Mol, Hans, Montazeri, Parisa, Murawski, Aline, Namorado, Sónia, Niemann, Lars, Nübler, Stefanie, Nunes, Baltazar, Olafsdottir, Kristin, Palkovicova Murinova, Lubica, Papaioannou, Nafsika, Pedraza-Diaz, Susana, Piler, Pavel, Plichta, Veronika, Poteser, Michael, Probst-Hensch, Nicole, Rambaud, Loïc, Rauscher-Gabernig, Elke, Rausova, Katarina, Remy, Sylvie, Riou, Margaux, Rosolen, Valentina, Rousselle, Christophe, Rüther, Maria, Sarigiannis, Denis, Silva, Maria J., Šlejkovec, Zdenka, Snoj Tratnik, Janja, Stajnko, Anja, Szigeti, Tamas, Tarazona, José V., Thomsen, Cathrine, Tkalec, Žiga, Tolonen, Hanna, Trnovec, Tomas, Uhl, Maria, Van Nieuwenhuyse, An, Vasco, Elsa, Verheyen, Veerle J., Viegas, Susana, Vinggaard, Anne Marie, Vogel, Nina, Vorkamp, Katrin, Wasowicz, Wojciech, Weber, Till, Wimmerova, Sona, Woutersen, Marjolijn, Zimmermann, Philipp, Zvonar, Martin, Koch, Holger, Kolossa-Gehring, Marike, Esteban López, Marta, Castaño, Argelia, Stewart, Lorraine, Sepai, Ovnair, Schoeters, Greet, Govarts, Eva, Gilles, Liese, Rodriguez Martin, Laura, Santonen, Tiina, Apel, Petra, Alvito, Paula, Anastasi, Elena, Andersen, Helle Raun, Andersson, Anna Maria, Andryskova, Lenka, Antignac, Jean Philippe, Appenzeller, Brice, Barbone, Fabio, Barnett-Itzhaki, Zohar, Barouki, Robert, Berman, Tamar, Bil, Wieneke, Borges, Teresa, Buekers, Jurgen, Cañas-Portilla, Ana, Covaci, Adrian, Csako, Zsofia, Den Hond, Elly, Dvorakova, Darina, Fabelova, Lucia, Fletcher, Tony, Frederiksen, Hanne, Gabriel, Catherine, Ganzleben, Catherine, Göen, Thomas, Halldorsson, Thorhallur I., Haug, Line S., Horvat, Milena, Huuskonen, Pasi, Imboden, Medea, Jagodic Hudobivnik, Marta, Janasik, Beata, Janev Holcer, Natasa, Karakitsios, Spyros, Katsonouri, Andromachi, Klanova, Jana, Kokaraki, Venetia, Kold Jensen, Tina, Koponen, Jani, Laeremans, Michelle, Laguzzi, Federica, Lange, Rosa, Lemke, Nora, Lignell, Sanna, Lindroos, Anna Karin, Lobo Vicente, Joana, Luijten, Mirjam, Makris, Konstantinos C., Mazej, Darja, Melymuk, Lisa, Meslin, Matthieu, Mol, Hans, Montazeri, Parisa, Murawski, Aline, Namorado, Sónia, Niemann, Lars, Nübler, Stefanie, Nunes, Baltazar, Olafsdottir, Kristin, Palkovicova Murinova, Lubica, Papaioannou, Nafsika, Pedraza-Diaz, Susana, Piler, Pavel, Plichta, Veronika, Poteser, Michael, Probst-Hensch, Nicole, Rambaud, Loïc, Rauscher-Gabernig, Elke, Rausova, Katarina, Remy, Sylvie, Riou, Margaux, Rosolen, Valentina, Rousselle, Christophe, Rüther, Maria, Sarigiannis, Denis, Silva, Maria J., Šlejkovec, Zdenka, Snoj Tratnik, Janja, Stajnko, Anja, Szigeti, Tamas, Tarazona, José V., Thomsen, Cathrine, Tkalec, Žiga, Tolonen, Hanna, Trnovec, Tomas, Uhl, Maria, Van Nieuwenhuyse, An, Vasco, Elsa, Verheyen, Veerle J., Viegas, Susana, Vinggaard, Anne Marie, Vogel, Nina, Vorkamp, Katrin, Wasowicz, Wojciech, Weber, Till, Wimmerova, Sona, Woutersen, Marjolijn, Zimmermann, Philipp, Zvonar, Martin, Koch, Holger, Kolossa-Gehring, Marike, Esteban López, Marta, Castaño, Argelia, Stewart, Lorraine, Sepai, Ovnair, and Schoeters, Greet
Abstract: As one of the core elements of the European Human Biomonitoring Initiative (HBM4EU) a human biomonitoring (HBM) survey was conducted in 23 countries to generate EU-wide comparable HBM data. This survey has built on existing HBM capacity in Europe by aligning national or regional HBM studies, referred to as the HBM4EU Aligned Studies. The HBM4EU Aligned Studies included a total of 10,795 participants of three age groups: (i) 3,576 children aged 6–12 years, (ii) 3,117 teenagers aged 12–18 years and (iii) 4,102 young adults aged 20–39 years. The participants were recruited between 2014 and 2021 in 11–12 countries per age group, geographically distributed across Europe. Depending on the age group, internal exposure to phthalates and the substitute DINCH, halogenated and organophosphorus flame retardants, per- and polyfluoroalkyl substances (PFASs), cadmium, bisphenols, polycyclic aromatic hydrocarbons (PAHs), arsenic species, acrylamide, mycotoxins (deoxynivalenol (total DON)), benzophenones and selected pesticides was assessed by measuring substance specific biomarkers subjected to stringent quality control programs for chemical analysis. For substance groups analyzed in different age groups higher average exposure levels were observed in the youngest age group, i.e., phthalates/DINCH in children versus teenagers, acrylamide and pesticides in children versus adults, benzophenones in teenagers versus adults. Many biomarkers in teenagers and adults varied significantly according to educational attainment, with higher exposure levels of bisphenols, phthalates, benzophenones, PAHs and acrylamide in participants (from households) with lower educational attainment, while teenagers from households with higher educational attainment have higher exposure levels for PFASs and arsenic. In children, a social gradient was only observed for the non-specific pyrethroid metabolite 3-PBA and di-isodecyl phthalate (DiDP), with higher levels in children from households with higher educat
Published: 2023

33. EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014–2021)

Author: Govarts, Eva, Gilles, Liese, Rodriguez Martin, Laura, Santonen, Tiina, Apel, Petra, Alvito, Paula, Anastasi, Elena, Andersen, Helle Raun, Andersson, Anna Maria, Andryskova, Lenka, Antignac, Jean Philippe, Appenzeller, Brice, Barbone, Fabio, Barnett-Itzhaki, Zohar, Barouki, Robert, Berman, Tamar, Bil, Wieneke, Borges, Teresa, Buekers, Jurgen, Cañas-Portilla, Ana, Covaci, Adrian, Csako, Zsofia, Den Hond, Elly, Dvorakova, Darina, Fabelova, Lucia, Fletcher, Tony, Frederiksen, Hanne, Gabriel, Catherine, Ganzleben, Catherine, Göen, Thomas, Halldorsson, Thorhallur I., Haug, Line S., Horvat, Milena, Huuskonen, Pasi, Imboden, Medea, Jagodic Hudobivnik, Marta, Janasik, Beata, Janev Holcer, Natasa, Karakitsios, Spyros, Katsonouri, Andromachi, Klanova, Jana, Kokaraki, Venetia, Kold Jensen, Tina, Koponen, Jani, Laeremans, Michelle, Laguzzi, Federica, Lange, Rosa, Lemke, Nora, Lignell, Sanna, Lindroos, Anna Karin, Lobo Vicente, Joana, Luijten, Mirjam, Makris, Konstantinos C., Mazej, Darja, Melymuk, Lisa, Meslin, Matthieu, Mol, Hans, Montazeri, Parisa, Murawski, Aline, Namorado, Sónia, Niemann, Lars, Nübler, Stefanie, Nunes, Baltazar, Olafsdottir, Kristin, Palkovicova Murinova, Lubica, Papaioannou, Nafsika, Pedraza-Diaz, Susana, Piler, Pavel, Plichta, Veronika, Poteser, Michael, Probst-Hensch, Nicole, Rambaud, Loïc, Rauscher-Gabernig, Elke, Rausova, Katarina, Remy, Sylvie, Riou, Margaux, Rosolen, Valentina, Rousselle, Christophe, Rüther, Maria, Sarigiannis, Denis, Silva, Maria J., Šlejkovec, Zdenka, Snoj Tratnik, Janja, Stajnko, Anja, Szigeti, Tamas, Tarazona, José V., Thomsen, Cathrine, Tkalec, Žiga, Tolonen, Hanna, Trnovec, Tomas, Uhl, Maria, Van Nieuwenhuyse, An, Vasco, Elsa, Verheyen, Veerle J., Viegas, Susana, Vinggaard, Anne Marie, Vogel, Nina, Vorkamp, Katrin, Wasowicz, Wojciech, Weber, Till, Wimmerova, Sona, Woutersen, Marjolijn, Zimmermann, Philipp, Zvonar, Martin, Koch, Holger, Kolossa-Gehring, Marike, Esteban López, Marta, Castaño, Argelia, Stewart, Lorraine, Sepai, Ovnair, Schoeters, Greet, and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Subjects: HBM4EU, SDG 3 - Good Health and Well-being, Public Health, Environmental and Occupational Health, Adults, Exposure biomarkers, Children, Teenagers, Human biomonitoring (HBM)
Abstract: Funding Information: The authors would like to thank everybody who contributed to the HBM4EU Aligned Studies: the participating children, teenagers, adults and their families, the fieldworkers that collected the samples and database managers that made the information available to HBM4EU, the HBM4EU project partners, especially those from WP7 for developing all materials supporting the fieldwork, WP9 for organizing the QA/QC scheme under HBM4EU and all laboratories who performed the analytical measurements. We would like to acknowledge Sun Kyoung Jung from the National Institute of Environmental Research of South-Korea for providing the KoNEHS Cycle III results (crt adjusted). HBM4EU is co-financed under Horizon 2020 (grant agreement No 733032). The authors thank all principal investigators of the contributing studies for their participation and contribution to the HBM4EU Aligned Studies and the national program owners for their financial support. Further details on funding for all the participating studies can be found in the Supplemental Material, Table S12. As one of the core elements of the European Human Biomonitoring Initiative (HBM4EU) a human biomonitoring (HBM) survey was conducted in 23 countries to generate EU-wide comparable HBM data. This survey has built on existing HBM capacity in Europe by aligning national or regional HBM studies, referred to as the HBM4EU Aligned Studies. The HBM4EU Aligned Studies included a total of 10,795 participants of three age groups: (i) 3,576 children aged 6–12 years, (ii) 3,117 teenagers aged 12–18 years and (iii) 4,102 young adults aged 20–39 years. The participants were recruited between 2014 and 2021 in 11–12 countries per age group, geographically distributed across Europe. Depending on the age group, internal exposure to phthalates and the substitute DINCH, halogenated and organophosphorus flame retardants, per- and polyfluoroalkyl substances (PFASs), cadmium, bisphenols, polycyclic aromatic hydrocarbons (PAHs), arsenic species, acrylamide, mycotoxins (deoxynivalenol (total DON)), benzophenones and selected pesticides was assessed by measuring substance specific biomarkers subjected to stringent quality control programs for chemical analysis. For substance groups analyzed in different age groups higher average exposure levels were observed in the youngest age group, i.e., phthalates/DINCH in children versus teenagers, acrylamide and pesticides in children versus adults, benzophenones in teenagers versus adults. Many biomarkers in teenagers and adults varied significantly according to educational attainment, with higher exposure levels of bisphenols, phthalates, benzophenones, PAHs and acrylamide in participants (from households) with lower educational attainment, while teenagers from households with higher educational attainment have higher exposure levels for PFASs and arsenic. In children, a social gradient was only observed for the non-specific pyrethroid metabolite 3-PBA and di-isodecyl phthalate (DiDP), with higher levels in children from households with higher educational attainment. Geographical variations were seen for all exposure biomarkers. For 15 biomarkers, the available health-based HBM guidance values were exceeded with highest exceedance rates for toxicologically relevant arsenic in teenagers (40%), 3-PBA in children (36%), and between 11 and 14% for total DON, Σ (PFOA + PFNA + PFHxS + PFOS), bisphenol S and cadmium. The infrastructure and harmonized approach succeeded in obtaining comparable European wide internal exposure data for a prioritized set of 11 chemical groups. These data serve as a reference for comparison at the global level, provide a baseline to compare the efficacy of the European Commission's chemical strategy for sustainability and will give leverage to national policy makers for the implementation of targeted measures. publishersversion published
Published: 2023

34. Interpreting biomonitoring data: Introducing the international human biomonitoring (i-HBM) working group's health-based guidance value (HB2GV) dashboard

Author: Nakayama, Shoji F., primary, St-Amand, Annie, additional, Pollock, Tyler, additional, Apel, Petra, additional, Bamai, Yu Ait, additional, Barr, Dana Boyd, additional, Bessems, Jos, additional, Calafat, Antonia M., additional, Castaño, Argelia, additional, Covaci, Adrian, additional, Duca, Radu Corneliu, additional, Faure, Sarah, additional, Galea, Karen S., additional, Hays, Sean, additional, Hopf, Nancy B., additional, Ito, Yuki, additional, Jeddi, Maryam Zare, additional, Kolossa-Gehring, Marike, additional, Kumar, Eva, additional, LaKind, Judy S., additional, López, Marta Esteban, additional, Louro, Henriqueta, additional, Macey, Kristin, additional, Makris, Konstantinos C., additional, Melnyk, Lisa, additional, Murawski, Aline, additional, Naiman, Josh, additional, Nassif, Julianne, additional, Noisel, Nolwenn, additional, Poddalgoda, Devika, additional, Quirós-Alcalá, Lesliam, additional, Rafiee, Ata, additional, Rambaud, Loïc, additional, Silva, Maria João, additional, Ueyama, Jun, additional, Verner, Marc-Andre, additional, Waras, Maisarah Nasution, additional, and Werry, Kate, additional
Published: 2023
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35. A longitudinal and multidesign epidemiological study to analyze the effect of the volcanic eruption of Tajogaite volcano (La Palma, Canary Islands). The ASHES study protocol

Author: Ruano-Ravina, Alberto, primary, Acosta, Orlando, additional, Díaz Pérez, David, additional, Casanova, Ciro, additional, Velasco, Valle, additional, Peces-Barba, Germán, additional, Barreiro, Esther, additional, Cañas, Ana, additional, Castaño, Argelia, additional, Cruz Carmona, María Jesús, additional, Diego, Carmen, additional, Garcia-Aymerich, Judith, additional, Martínez, Cristina, additional, Molina-Molina, María, additional, Muñoz, Xavier, additional, Sánchez-Íñigo, Francisco Javier, additional, and Candal-Pedreira, Cristina, additional
Published: 2023
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36. Exposure to flame retardants in European children — Results from the HBM4EU aligned studies

Author: van der Schyff, Veronica, primary, Kalina, Jiři, additional, Govarts, Eva, additional, Gilles, Liese, additional, Schoeters, Greet, additional, Castaño, Argelia, additional, Esteban-López, Marta, additional, Kohoutek, Jiři, additional, Kukučka, Petr, additional, Covaci, Adrian, additional, Koppen, Gudrun, additional, Andrýsková, Lenka, additional, Piler, Pavel, additional, Klánová, Jana, additional, Jensen, Tina Kold, additional, Rambaud, Loic, additional, Riou, Margaux, additional, Lamoree, Marja, additional, Kolossa-Gehring, Marike, additional, Vogel, Nina, additional, Weber, Till, additional, Göen, Thomas, additional, Gabriel, Catherine, additional, Sarigiannis, Dimosthenis A., additional, Sakhi, Amrit Kaur, additional, Haug, Line Småstuen, additional, Murinova, Lubica Palkovicova, additional, Fabelova, Lucia, additional, Tratnik, Janja Snoj, additional, Mazej, Darja, additional, and Melymuk, Lisa, additional
Published: 2023
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37. Cross-sectional associations between exposure to per- and polyfluoroalkyl substances and body mass index among European teenagers in the HBM4EU aligned studies

Author: Schillemans, Tessa, primary, Iszatt, Nina, additional, Remy, Sylvie, additional, Schoeters, Greet, additional, Fernández, Mariana F., additional, D'Cruz, Shereen Cynthia, additional, Desalegn, Anteneh, additional, Haug, Line S., additional, Lignell, Sanna, additional, Lindroos, Anna Karin, additional, Fábelová, Lucia, additional, Murinova, Lubica Palkovicova, additional, Kosjek, Tina, additional, Tkalec, Žiga, additional, Gabriel, Catherine, additional, Sarigiannis, Denis, additional, Pedraza-Díaz, Susana, additional, Esteban-López, Marta, additional, Castaño, Argelia, additional, Rambaud, Loïc, additional, Riou, Margaux, additional, Pauwels, Sara, additional, Vanlarebeke, Nik, additional, Kolossa-Gehring, Marike, additional, Vogel, Nina, additional, Uhl, Maria, additional, Govarts, Eva, additional, and Åkesson, Agneta, additional
Published: 2023
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38. From science to policy: How European HBM indicators help to answer policy questions related to phthalates and DINCH exposure

Author: Gerofke, Antje, primary, David, Madlen, additional, Schmidt, Phillipp, additional, Vicente, Joana Lobo, additional, Buekers, Jurgen, additional, Gilles, Liese, additional, Colles, Ann, additional, Bessems, Jos, additional, Bastiaensen, Michiel, additional, Covaci, Adrian, additional, Den Hond, Elly, additional, Koppen, Gudrun, additional, Laeremans, Michelle, additional, Verheyen, Veerle J., additional, Černá, Milena, additional, Klánová, Jana, additional, Krsková, Andrea, additional, Zvonař, Martin, additional, Knudsen, Lisbeth E., additional, Koch, Holger M., additional, Jensen, Tina Kold, additional, Rambaud, Loïc, additional, Riou, Margaux, additional, Vogel, Nina, additional, Gabriel, Catherine, additional, Karakitsios, Spyros, additional, Papaioannou, Nafsika, additional, Sarigiannis, Denis, additional, Kakucs, Réka, additional, Középesy, Szilvia, additional, Rudnai, Péter, additional, Szigeti, Tamás, additional, Barbone, Fabio, additional, Rosolen, Valentina, additional, Guignard, Cedric, additional, Gutleb, Arno C., additional, Sakhi, Amrit Kaur, additional, Haug, Line Småstuen, additional, Janasik, Beata, additional, Ligocka, Danuta, additional, Estokova, Milada, additional, Fabelova, Lucia, additional, Kolena, Branislav, additional, Murinova, Lubica Palkovicova, additional, Petrovicova, Ida, additional, Richterova, Denisa, additional, Horvat, Milena, additional, Mazej, Darja, additional, Tratnik, Janja Snoj, additional, Runkel, Agneta Annika, additional, Castaño, Argelia, additional, Esteban-López, Marta, additional, Pedraza-Díaz, Susana, additional, Åkesson, Agneta, additional, Lignell, Sanna, additional, Vlaanderen, Jelle, additional, Zock, Jan-Paul, additional, Schoeters, Greet, additional, and Kolossa-Gehring, Marike, additional
Published: 2023
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39. Current exposure to phthalates and DINCH in European children and adolescents - Results from the HBM4EU Aligned Studies 2014 to 2021

Author: Vogel, Nina, Schmidt, Phillipp, Lange, Rosa, Gerofke, Antje, Sakhi, Amrit K, Haug, Line S, Jensen, Tina Kold, Frederiksen, Hanne, Szigeti, Tamás, Csákó, Zsófia, Murinova, Lubica Palkovicova, Sidlovska, Miroslava, Janasik, Beata, Wasowicz, Wojciech, Tratnik, Janja Snoj, Mazej, Darja, Gabriel, Catherine, Karakitsios, Spyros, Barbone, Fabio, Rosolen, Valentina, Rambaud, Loïc, Riou, Margaux, Murawski, Aline, Leseman, Daan, Koppen, Gudrun, Covaci, Adrian, Lignell, Sanna, Lindroos, Anna Karin, Zvonar, Martin, Andryskova, Lenka, Fabelova, Lucia, Richterova, Denisa, Horvat, Milena, Kosjek, Tina, Sarigiannis, Denis, Maroulis, Marios, Pedraza-Diaz, Susana, Cañas, Ana, Verheyen, Veerle J, Bastiaensen, Michiel, Gilles, Liese, Schoeters, Greet, Esteban-López, Marta, Castaño, Argelia, Govarts, Eva, Koch, Holger M, and Kolossa-Gehring, Marike
Subjects: HBM4EU, Phthalates, DINCH, Adolescents, Children, HBM, Exposure
Published: 2023

40. Literature review and evaluation of biomarkers, matrices and analytical methods for chemicals selected in the research program Human Biomonitoring for the European Union (HBM4EU)

Author: Sabbioni, Gabriele, primary, Castaño, Argelia, additional, Esteban López, Marta, additional, Göen, Thomas, additional, Mol, Hans, additional, Riou, Margaux, additional, and Tagne-Fotso, Romuald, additional
Published: 2022
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41. Analysis of Exposure and Respiratory Health Effects of Volcanic Eruption in the Canary Islands (ASHES). A SEPAR Study

Author: Ruano-Ravina, Alberto, primary, Acosta, Orlando, additional, Díaz Pérez, David, additional, Casanova, Ciro, additional, Velasco, Valle, additional, Llanos, Ana Belén, additional, Peces-Barba, Germán, additional, Barreiro, Esther, additional, Cañas, Ana, additional, Castaño, Argelia, additional, Cruz Carmona, María Jesús, additional, Diego, Carmen, additional, Garcia-Aymerich, Judith, additional, Martínez, Cristina, additional, Molina-Molina, María, additional, Muñoz, Xavier, additional, Sánchez-Íñigo, Francisco Javier, additional, and Candal-Pedreira, Cristina, additional
Published: 2022
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42. Personal care product use and lifestyle affect phthalate and DINCH metabolite levels in teenagers and young adults

Author: Stuchlík Fišerová, Petra, primary, Melymuk, Lisa, additional, Komprdová, Klára, additional, Domínguez-Romero, Elena, additional, Scheringer, Martin, additional, Kohoutek, Jiří, additional, Přibylová, Petra, additional, Andrýsková, Lenka, additional, Piler, Pavel, additional, Koch, Holger M., additional, Zvonař, Martin, additional, Esteban-López, Marta, additional, Castaño, Argelia, additional, and Klánová, Jana, additional
Published: 2022
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43. Glyphosate and AMPA in Human Urine of HBM4EU-Aligned Studies: Part B Adults

Author: Buekers, Jurgen, primary, Remy, Sylvie, additional, Bessems, Jos, additional, Govarts, Eva, additional, Rambaud, Loïc, additional, Riou, Margaux, additional, Halldorsson, Thorhallur I, additional, Ólafsdóttir, Kristin, additional, Probst-Hensch, Nicole, additional, Ammann, Priska, additional, Weber, Till, additional, Kolossa-Gehring, Marike, additional, Esteban-López, Marta, additional, Castaño, Argelia, additional, Andersen, Helle Raun, additional, and Schoeters, Greet, additional
Published: 2022
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44. Cadmium exposure in adults across Europe: Results from the HBM4EU Aligned Studies survey 2014–2020

Author: Snoj Tratnik, Janja, primary, Kocman, David, additional, Horvat, Milena, additional, Andersson, Anna-Maria, additional, Juul, Anders, additional, Jacobsen, Eva, additional, Ólafsdóttir, Kristin, additional, Klanova, Jana, additional, Andryskova, Lenka, additional, Janasik, Beata, additional, Wasowicz, Wojciech, additional, Janev Holcer, Natasa, additional, Namorado, Sónia, additional, Coelho, Inês, additional, Rambaud, Loïc, additional, Riou, Margaux, additional, Van Nieuwenhuyse, An, additional, Appenzeller, Brice, additional, Kolossa-Gehring, Marike, additional, Weber, Till, additional, Esteban-López, Marta, additional, Castaño, Argelia, additional, Gilles, Liese, additional, Rodriguez Marti, Laura, additional, Schoeters, Greet, additional, Sepai, Ovnair, additional, and Govarts, Eva, additional
Published: 2022
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45. Cumulative risk assessment of five phthalates in European children and adolescents

Author: Lange, Rosa, primary, Vogel, Nina, additional, Schmidt, Phillipp, additional, Gerofke, Antje, additional, Luijten, Mirjam, additional, Bil, Wieneke, additional, Santonen, Tiina, additional, Schoeters, Greet, additional, Gilles, Liese, additional, Sakhi, Amrit K., additional, Haug, Line S., additional, Jensen, Tina K., additional, Frederiksen, Hanne, additional, Koch, Holger M., additional, Szigeti, Tamás, additional, Szabados, Máté, additional, Tratnik, Janja Snoj, additional, Mazej, Darja, additional, Gabriel, Catherine, additional, Sarigiannis, Dimosthenis, additional, Dzhedzheia, Vazha, additional, Karakitsios, Spyros, additional, Rambaud, Loïc, additional, Riou, Margaux, additional, Koppen, Gudrun, additional, Covaci, Adrian, additional, Zvonař, Martin, additional, Piler, Pavel, additional, Klánová, Jana, additional, Fábelová, Lucia, additional, Richterová, Denisa, additional, Kosjek, Tina, additional, Runkel, Agneta, additional, Pedraza-Díaz, Susana, additional, Verheyen, Veerle, additional, Bastiaensen, Michiel, additional, Esteban-López, Marta, additional, Castaño, Argelia, additional, and Kolossa-Gehring, Marike, additional
Published: 2022
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46. Testing in Aquatic Ecotoxicology: What Are the Scientific Conditions for the ‘3R’ Concept?

Author: Pärt, Peter, Castaño, Argelia, Bengtsson, Bengt-Erik, Eriksson, Johan, editor, Gilek, Michael, editor, and Rudén, Christina, editor
Published: 2010
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47. Cadmium levels in a representative sample of the Spanish adult population: The BIOAMBIENT.ES project

Author: López-Herranz, Ana, Cutanda, Francisco, Esteban, Marta, Pollán, Marina, Calvo, Eva, Pérez-Gómez, Beatriz, Victoria Cortes, Maria, and Castaño, Argelia
Published: 2016
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48. A fast method for analysing six perfluoroalkyl substances in human serum by solid-phase extraction on-line coupled to liquid chromatography tandem mass spectrometry

Author: Bartolomé, Mónica, Gallego-Picó, Alejandrina, Huetos, Olga, Lucena, Miguel Ángel, and Castaño, Argelia
Published: 2016
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49. Glyphosate and AMPA in Human Urine of HBM4EU Aligned Studies: Part A Children

Author: Buekers, Jurgen, primary, Remy, Sylvie, additional, Bessems, Jos, additional, Govarts, Eva, additional, Rambaud, Loïc, additional, Riou, Margaux, additional, Tratnik, Janja Snoj, additional, Stajnko, Anja, additional, Katsonouri, Andromachi, additional, Makris, Konstantinos C., additional, De Decker, Annelies, additional, Morrens, Bert, additional, Vogel, Nina, additional, Kolossa-Gehring, Marike, additional, Esteban-López, Marta, additional, Castaño, Argelia, additional, Andersen, Helle Raun, additional, and Schoeters, Greet, additional
Published: 2022
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50. A Tiered Approach for Assessing Individual and Combined Risk of Pyrethroids Using Human Biomonitoring Data

Author: Tarazona, Jose V., primary, Cattaneo, Irene, additional, Niemann, Lars, additional, Pedraza-Diaz, Susana, additional, González-Caballero, Maria Carmen, additional, de Alba-Gonzalez, Mercedes, additional, Cañas, Ana, additional, Dominguez-Morueco, Noelia, additional, Esteban-López, Marta, additional, Castaño, Argelia, additional, Borges, Teresa, additional, Katsonouri, Andromachi, additional, Makris, Konstantinos C., additional, Ottenbros, Ilse, additional, Mol, Hans, additional, De Decker, Annelies, additional, Morrens, Bert, additional, Berman, Tamar, additional, Barnett-Itzhaki, Zohar, additional, Probst-Hensch, Nicole, additional, Fuhrimann, Samuel, additional, Tratnik, Janja Snoj, additional, Horvat, Milena, additional, Rambaud, Loic, additional, Riou, Margaux, additional, Schoeters, Greet, additional, Govarts, Eva, additional, Kolossa-Gehring, Marike, additional, Weber, Till, additional, Apel, Petra, additional, Namorado, Sonia, additional, and Santonen, Tiina, additional
Published: 2022
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