2,796 results on '"Cassoni, A."'
Search Results
2. Combined transarterial chemoembolization and thermal ablation in candidates to liver transplantation with hepatocellular carcinoma: pathological findings and post-transplant outcome
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Fronda, Marco, Susanna, Eleonora, Doriguzzi Breatta, Andrea, Gazzera, Carlo, Patrono, Damiano, Piccione, Federica, Bertero, Luca, Ciferri, Fernanda, Carucci, Patrizia, Gaia, Silvia, Rolle, Emanuela, Vocino Trucco, Giulia, Bergamasco, Laura, Tandoi, Francesco, Cassoni, Paola, Romagnoli, Renato, Fonio, Paolo, and Calandri, Marco
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- 2024
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3. Rotorcraft stability analysis using Lyapunov characteristic exponents estimated from multibody dynamics
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Cassoni, Gianni, Cocco, Alessandro, Tamer, Aykut, Zanoni, Andrea, and Masarati, Pierangelo
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- 2024
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4. ATUAÇÃO DO PSICÓLOGO FRENTE A COMUNIDADE LGBTQIA+
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Carvalho, Giovanna Della Coletta, primary, Pfefer, Julia, additional, Paiva, Sofia Fornazari, additional, and Cassoni, Cynthia, additional
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- 2024
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5. Molecular neuropathology: an essential and evolving toolbox for the diagnosis and clinical management of central nervous system tumors
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Bertero, Luca, Mangherini, Luca, Ricci, Alessia Andrea, Cassoni, Paola, and Sahm, Felix
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- 2024
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6. Removing color while lowering toxicity: the case for decolorization of textile dyes and simulated effluents with yeasts
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Mendes, M., Cassoni, A. C., Alves, S., Moreira, P., Pintado, M. E., and Castro, P. M. L.
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- 2024
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7. Circulating autoantibodies to alpha-enolase (ENO1) and far upstream element-binding protein 1 (FUBP1) are negative prognostic factors for pancreatic cancer patient survival
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Curcio, Claudia, Rosso, Tiziana, Brugiapaglia, Silvia, Guadagnin, Giorgia, Giordano, Daniele, Castellino, Bruno, Satolli, Maria Antonietta, Spadi, Rosella, Campra, Donata, Moro, Francesco, Papotti, Mauro Giulio, Bertero, Luca, Cassoni, Paola, De Angelis, Claudio, Langella, Serena, Ferrero, Alessandro, Armentano, Serena, Bellotti, Giovanna, Fenocchio, Elisabetta, Nuzzo, Annamaria, Ciccone, Giovannino, and Novelli, Francesco
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- 2023
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8. Orthostatic Ex-Vivo Lung Perfusion (EVLP): A Proof of Concept
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Massimo Boffini, Andrea Costamagna, Matteo Marro, Erika Simonato, Paola Cassoni, Luca Bertero, Vito Fanelli, Cristina Barbero, Luca Brazzi, and Mauro Rinaldi
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lung transplant ,animal model ,EVLP ,organ preservation ,perfusion ,Specialties of internal medicine ,RC581-951 - Abstract
The key goal in lung donation remains the improvement of graft preservation with the ultimate objective of increasing the number and quality of lung transplants (LTx). Therefore, in recent years the field of graft preservation focused on improving outcomes related to solid organ regeneration and restoration. In this contest Ex-Vivo Lung Perfusion (EVLP) plays a crucial role with the purpose to increase the donor pool availability transforming marginal and/or declined donor lungs suitable for transplantation. Aim of this proof of concept is to test the safety, suitability and feasibility of a new tilting dome for EVLP designed considering the dorsal lung areas as the “Achilles’ heel” of the EVLP due to a more fluid accumulation than in the supine standard position.
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- 2024
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9. Prognostic and predictive role of YKL-40 in anal squamous cell carcinoma: a serological and tissue-based analysis in a multicentric cohort
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Alessandro Gambella, Rebecca Senetta, Enrico Costantino Falco, Alessia Andrea Ricci, Luca Mangherini, Cristian Tampieri, Jessica Fissore, Giulia Orlando, Tilde Manetta, Giulio Mengozzi, Massimiliano Mistrangelo, Luca Bertero, and Paola Cassoni
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radiochemotherapy ,nigro protocol ,immunohistochemistry ,serum biomarkers ,overall survival ,response to treatment ,Medicine (General) ,R5-920 - Abstract
IntroductionAnal squamous cell carcinoma (ASC) is a rare gastrointestinal malignancy showing an increased incidence over the past decades. YKL-40 is an immune modulator and pro-angiogenetic factor that showed a promising prognostic and predictive potential in several malignancies, but limited data are available for ASC. This study aims to provide an extensive evaluation of the prognostic and predictive role of YKL-40 in a multicenter cohort of ASC patients.MethodsWe retrospectively retrieved 72 consecutive cases of ASC diagnosed between February 2011 and March 2021. Both serum and tissue protein expression of YKL-40 were assessed, the latter in ASC tumor cells and peritumor immune cells.ResultsIncreased YKL-40 serum levels at the time of diagnosis were associated with older age (p = 0.035), presence of cardiovascular/metabolic comorbidities (p = 0.007), and death for any cause (p = 0.011). In addition, high serum levels of YKL-40 were associated with a poor prognosis (HR: 2.82, 95% CI: 1.01–7.84; p = 0.047). Protein expression of YKL-40 in ASC tumor cells was significantly associated with low tumor grade (p = 0.031), while the increased expression in peritumor immune cells was associated with a worse response of patients to chemoradiotherapy (p = 0.007). However, YKL-40 protein expression in ASC tumor cells or peritumor immune cells did not significantly impact patient overall survival.DiscussionIn conclusion, YKL-40 resulted a relevant prognostic (serum level) and predictive (tissue protein expression in peritumor immune cells) biomarker and can considerably improve ASC patient clinical management.
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- 2024
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10. Bone-flap-harvest-related donor site morbidity in reconstructive jaw microsurgery: Retrospective analysis based on 220 patients over a ten-year period
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Di Giorgio, Danilo, Della Monaca, Marco, Nocini, Riccardo, Battisti, Andrea, Pagnani, Giulio, Priore, Paolo, Terenzi, Valentina, Cassoni, Andrea, and Valentini, Valentino
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- 2024
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11. Electrodeposition of organic corrosion inhibitor prepared from eucalyptus robusta leaves
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Camaratta, Rubens, Cardoso, Frantchescole B., Lourenço, Núbia C., Cassoni, Felipe R., Silva, Silvia H.F., Cholant, Camila M., Gonçalves, Alice O., Machado, Fernando M., and Avellaneda, César O.
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- 2024
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12. Genomic and Transcriptomic Profile of HNF1A-Mutated Liver Adenomas Highlights Molecular Signature and Potential Therapeutic Implications
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Angelo Corso Faini, Francesca Arruga, Michele Pinon, Valeria Bracciamà, Francesco Edoardo Vallone, Fiorenza Mioli, Monica Sorbini, Martina Migliorero, Alessandro Gambella, Damiano Carota, Isaac Giraudo, Paola Cassoni, Silvia Catalano, Renato Romagnoli, Antonio Amoroso, Pier Luigi Calvo, Tiziana Vaisitti, and Silvia Deaglio
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HNF1A ,hepatic adenomas ,liver ,molecular signature ,genetics ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Hepatocellular adenomas (HAs) are tumors that can develop under different conditions, including in patients harboring a germline mutation in HNF1A. However, little is known about the pathogenesis of such disease. This work aims to better define what mechanisms lie under the development of this condition. Six HAs were sampled from the liver of a 17-year-old male affected by diabetes and multiple hepatic adenomatosis harboring the heterozygous pathogenic germline variant c.815G>A, p.(Arg272His) in HNF1A, which has a dominant negative effect. All HAs were molecularly characterized. Four of them were shown to harbor a second somatic HNF1A variant and one had a mutation in the ARID1A gene, while no additional somatic changes were found in the remaining HA and normal parenchyma. A transcriptomic profile of the same HA samples was also performed. HNF1A biallelic mutations were associated with the up-regulation of several pathways including the tricarboxylic acid cycle, the metabolism of fatty acids, and mTOR signaling while angiogenesis, endothelial and vascular proliferation, cell migration/adhesion, and immune response were down-regulated. Contrariwise, in the tumor harboring the ARID1A variant, angiogenesis was up-modulated while fatty acid metabolism was down-modulated. Histological analyses confirmed the molecular data. Independently of the second mutation, energetic processes and cholesterol metabolism were up-modulated, while the immune response was down-modulated. This work provides a complete molecular signature of HNF1A-associated HAs, analyzing the association between specific HNF1A variants and the development of HA while identifying potential new therapeutic targets for non-surgical treatment.
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- 2024
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13. Jaw Reconstruction with Scapular Bone Flap and Prosthetic Implant Rehabilitation: A Comprehensive Systematic Review
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Danilo Di Giorgio, Riccardo Nocini, Mattia Di Bartolomeo, Matteo Fatiga, Marco Della Monaca, Paolo Priore, Valentina Terenzi, Andrea Battisti, Andrea Cassoni, and Valentino Valentini
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scapula flap ,subscapular-based flaps ,microsurgery ,osseous flaps ,dental implants ,implant-prosthetic rehabilitation ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
A rising demand for prosthetic-driven jaw reconstruction is encountered in maxillo-facial surgery. The free scapula flap is a workhorse of cervico-facial reconstructions, but an implant-based prosthetic rehabilitation on this flap is a debated topic. A systematic review of the papers on this subject has been conducted on Embase, MEDLINE, and Cochrane libraries following PRISMA guidelines, in order to analyze the results described in the literature. A total of nine papers were eligible for inclusion, with 83 scapula flaps overall being used for an implant-based prosthetic rehabilitation. The mandible was the reconstructed jaw in 58.0% of the cases. Overall, 249 implants were positioned (mean 3.0 implant per flap) with a 3.6% implant failure rate. In 95.2% of the cases, delayed rehabilitation was performed. Radiotherapy and the timing of implant placement did not seem to influence implant failure. Only two papers analyzed the quality of life following the rehabilitation, highlighting a functional improvement. Scapula-based implant-prosthetic rehabilitation is a feasible technique that can also benefit from the new CAD/CAM technologies and digital workflows. Nonetheless, further studies focused on this topic and on its impact on the quality of life are needed in order to analyze risk factors and to optimize the outcomes.
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- 2024
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14. SIED-GISCOR recommendations for colonoscopy in screening programs: Part I – Diagnostic
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Parodi, Maria Caterina, Antonelli, Giulio, Galloro, Giuseppe, Radaelli, Franco, Manes, Giampiero, Manno, Mauro, Camellini, Lorenzo, Sereni, Giuliana, Caserta, Luigi, Arrigoni, Arrigo, Fasoli, Renato, Sassatelli, Romano, Pigò, Flavia, Iovino, Paola, Scimeca, Daniela, De Luca, Luca, Rizkala, Tommy, Tringali, Alberto, Campari, Cinzia, Capogreco, Antonio, Testoni, Sabrina Gloria Giulia, Bertani, Helga, Fantin, Alberto, Mitri, Roberto Di, Familiari, Pietro, Labardi, Maurizio, De Angelis, Claudio, Anghinoni, Emanuela, Rubeca, Tiziana, Cassoni, Paola, Zorzi, Manuel, Mussetto, Alessandro, Hassan, Cesare, and Senore, Carlo
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- 2024
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15. A novel prognostic model based on pretreatment serum albumin and ECOG PS for primary CNS lymphoma: an international, multi-center study
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Wei, Li, Gao, Yuting, Prochazka, Katharina Theresa, Liu, Rongqiu, Wang, Liang, Liu, Boyang, He, Yingzhi, Bertero, Luca, Pellerino, Alessia, Cassoni, Paola, Tamagnone, Luca, Deutsch, Alexander J., Zhan, Huien, Lai, Jing, Kim, Seok Jin, and You, Hua
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- 2023
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16. Improved assessment of donor liver steatosis using Banff consensus recommendations and deep learning algorithms
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Gambella, Alessandro, Salvi, Massimo, Molinaro, Luca, Patrono, Damiano, Cassoni, Paola, Papotti, Mauro, Romagnoli, Renato, and Molinari, Filippo
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- 2024
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17. Dysplasia grading of colorectal polyps through CNN analysis of WSI
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Perlo, Daniele, Tartaglione, Enzo, Bertero, Luca, Cassoni, Paola, and Grangetto, Marco
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Electrical Engineering and Systems Science - Image and Video Processing ,Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Machine Learning - Abstract
Colorectal cancer is a leading cause of cancer death for both men and women. For this reason, histopathological characterization of colorectal polyps is the major instrument for the pathologist in order to infer the actual risk for cancer and to guide further follow-up. Colorectal polyps diagnosis includes the evaluation of the polyp type, and more importantly, the grade of dysplasia. This latter evaluation represents a critical step for the clinical follow-up. The proposed deep learning-based classification pipeline is based on state-of-the-art convolutional neural network, trained using proper countermeasures to tackle WSI high resolution and very imbalanced dataset. The experimental results show that one can successfully classify adenomas dysplasia grade with 70% accuracy, which is in line with the pathologists' concordance.
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- 2021
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18. UniToPatho, a labeled histopathological dataset for colorectal polyps classification and adenoma dysplasia grading
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Barbano, Carlo Alberto, Perlo, Daniele, Tartaglione, Enzo, Fiandrotti, Attilio, Bertero, Luca, Cassoni, Paola, and Grangetto, Marco
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Electrical Engineering and Systems Science - Image and Video Processing ,Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Machine Learning ,I.2.0 ,I.2.6 - Abstract
Histopathological characterization of colorectal polyps allows to tailor patients' management and follow up with the ultimate aim of avoiding or promptly detecting an invasive carcinoma. Colorectal polyps characterization relies on the histological analysis of tissue samples to determine the polyps malignancy and dysplasia grade. Deep neural networks achieve outstanding accuracy in medical patterns recognition, however they require large sets of annotated training images. We introduce UniToPatho, an annotated dataset of 9536 hematoxylin and eosin (H&E) stained patches extracted from 292 whole-slide images, meant for training deep neural networks for colorectal polyps classification and adenomas grading. We present our dataset and provide insights on how to tackle the problem of automatic colorectal polyps characterization., Comment: 5 pages, 3 figures
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- 2021
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19. Protocol for the Extraction of Lignin from Brewer’s Spent Grain Using Deep Eutectic Solvents
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Cassoni, Ana C., Costa, Patrícia, Pintado, Manuela, Sant'Ana, Anderson S., Series Editor, Aguilar Gonzalez, Cristobal N., editor, Gómez-García, Ricardo, editor, and Kuddus, Mohammed, editor
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- 2023
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20. Valorization of Agricultural Lignocellulosic Plant Byproducts Following Biorefinery Approach Toward Circular Bioeconomy
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Cassoni, A. C., Gómez-García, R., Pintado, M., Ramawat, Kishan Gopal, Series Editor, Ramawat, K.G., editor, Mérillon, Jean-Michel, editor, and Arora, Jaya, editor
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- 2023
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21. Transoral versus transfacial surgical approach to maxillary tumors: evaluation of outcomes and perspectives
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Pucci, R., Cassoni, A., Weyh, A., Mangini, N., Della Monaca, M., Battisti, A., Fernandes, R., and Valentini, V.
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- 2024
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22. Dermal Regeneration Template: Reconstruction in Oral Cancer Defects
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Mangini, Nicolò, Galvano, Francesca, Pucci, Resi, Battisti, Andrea, Cassoni, Andrea, and Valentini, Valentino
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- 2023
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23. O fenômeno da violência familiar no contexto da pandemia de COVID-19: Revisão sistemática
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Silva, Danielly Teles da, primary, Barauna, Fabiana de Moura dos Santos, additional, Guedes, Gislaine de Oliveira, additional, and Cassoni, Cynthia, additional
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- 2023
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24. COVID-19 and Breast Cancer: Analysis of Surgical Management of a Large Referral Center during the 2020–2021 Pandemic Period
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Fulvio Borella, Luca Bertero, Fabrizia Di Giovanni, Gianluca Witel, Giulia Orlando, Alessia Andrea Ricci, Alessandra Pittaro, Isabella Castellano, and Paola Cassoni
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COVID-19 ,SARS-CoV-2 ,breast cancer ,surgery ,pandemic ,management ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background: Coronavirus disease-19 (COVID-19) has spread worldwide since December 2019 and was officially declared a pandemic in March 2020. Due to the rapid transmission and the high fatality rate, drastic emergency restrictions were issued, with a negative impact on routine clinical activities. In particular, in Italy, many authors have reported a reduction in the number of breast cancer diagnoses and critical problems in the management of patients who accessed the breast units during the dramatic first months of the pandemic. Our study aims to analyze the global impact of COVID-19 in the two years of the pandemic (2020–2021) on the surgical management of breast cancer by comparing them with the previous two years. Methods: In our retrospective study, we analyzed all cases of breast cancer diagnosed and surgically treated at the breast unit of “Città della Salute e della Scienza” in Turin, Italy, making a comparison between the 2018–2019 pre-pandemic period and the 2020–2021 pandemic period. Results: We included in our analysis 1331 breast cancer cases surgically treated from January 2018 to December 2021. A total of 726 patients were treated in the pre-pandemic years and 605 in the pandemic period (−121 cases, 9%). No significant differences were observed regarding diagnosis (screening vs. no screening) and timing between radiological diagnosis and surgery for both in situ and invasive tumors. There were no variations in the breast surgical approach (mastectomy vs. conservative surgery), while a reduction in axillary dissection compared to the sentinel lymph node in the pandemic period was observed (p-value < 0.001). Regarding the biological characteristics of breast cancers, we observed a greater number of grades 2–3 (p-value = 0.007), pT stage 3–4 breast cancer surgically treated without previous neoadjuvant chemotherapy (p-value = 0.03), and a reduction in luminal B tumors (p-value = 0.007). Conclusions: Overall, we report a limited reduction in surgical activity for breast cancer treatment considering the entire pandemic period (2020–2021). These results suggest a prompt resumption of surgical activity similar to the pre-pandemic period.
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- 2023
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25. Firmness prediction of 'Rocha' pear based on non-destructive methods and shelf-life using PLS-regression modeling
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Dias, Cindy, Brandão, Teresa R.S., Cassoni, Carolina, Vasconcelos, Marta W., Ferrante, António, and Pintado, Manuela
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- 2023
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26. Neuroendocrine neoplasms of the breast: diagnostic agreement and impact on outcome
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Metovic, Jasna, Cascardi, Eliano, Uccella, Silvia, Maragliano, Roberta, Querzoli, Giulia, Osella-Abate, Simona, Pittaro, Alessandra, La Rosa, Stefano, Bogina, Giuseppe, Cassoni, Paola, Marchiò, Caterina, Sapino, Anna, Castellano, Isabella, and Papotti, Mauro
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- 2022
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27. Clinical and Histopathological Predictors of Recurrence in Uterine Smooth Muscle Tumor of Uncertain Malignant Potential (STUMP): A Multicenter Retrospective Cohort Study of Tertiary Centers
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Borella, Fulvio, Cosma, Stefano, Ferraioli, Domenico, Ray-Coquard, Isabelle, Chopin, Nicolas, Meeus, Pierre, Cockenpot, Vincent, Valabrega, Giorgio, Scotto, Giulia, Turinetto, Margherita, Biglia, Nicoletta, Fuso, Luca, Mariani, Luca, Franchi, Dorella, Vidal Urbinati, Ailyn Mariela, Pino, Ida, Bertschy, Gianluca, Preti, Mario, Benedetto, Chiara, Castellano, Isabella, Cassoni, Paola, and Bertero, Luca
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- 2022
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28. Cohort profile: the Turin prostate cancer prognostication (TPCP) cohort
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Nicolas Destefanis, Valentina Fiano, Lorenzo Milani, Paolo Vasapolli, Michelangelo Fiorentino, Francesca Giunchi, Luca Lianas, Mauro Del Rio, Francesca Frexia, Luca Pireddu, Luca Molinaro, Paola Cassoni, Mauro Giulio Papotti, Paolo Gontero, Giorgio Calleris, Marco Oderda, Umberto Ricardi, Giuseppe Carlo Iorio, Piero Fariselli, Elena Isaevska, Olof Akre, Renata Zelic, Andreas Pettersson, Daniela Zugna, and Lorenzo Richiardi
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prostate cancer ,prognosis ,prognostic modelling ,digital pathology ,DNA methylation ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
IntroductionProstate cancer (PCa) is the most frequent tumor among men in Europe and has both indolent and aggressive forms. There are several treatment options, the choice of which depends on multiple factors. To further improve current prognostication models, we established the Turin Prostate Cancer Prognostication (TPCP) cohort, an Italian retrospective biopsy cohort of patients with PCa and long-term follow-up. This work presents this new cohort with its main characteristics and the distributions of some of its core variables, along with its potential contributions to PCa research.MethodsThe TPCP cohort includes consecutive non-metastatic patients with first positive biopsy for PCa performed between 2008 and 2013 at the main hospital in Turin, Italy. The follow-up ended on December 31st 2021. The primary outcome is the occurrence of metastasis; death from PCa and overall mortality are the secondary outcomes. In addition to numerous clinical variables, the study’s prognostic variables include histopathologic information assigned by a centralized uropathology review using a digital pathology software system specialized for the study of PCa, tumor DNA methylation in candidate genes, and features extracted from digitized slide images via Deep Neural Networks.ResultsThe cohort includes 891 patients followed-up for a median time of 10 years. During this period, 97 patients had progression to metastatic disease and 301 died; of these, 56 died from PCa. In total, 65.3% of the cohort has a Gleason score less than or equal to 3 + 4, and 44.5% has a clinical stage cT1. Consistent with previous studies, age and clinical stage at diagnosis are important prognostic factors: the crude cumulative incidence of metastatic disease during the 14-years of follow-up increases from 9.1% among patients younger than 64 to 16.2% for patients in the age group of 75-84, and from 6.1% for cT1 stage to 27.9% in cT3 stage.DiscussionThis study stands to be an important resource for updating existing prognostic models for PCa on an Italian cohort. In addition, the integrated collection of multi-modal data will allow development and/or validation of new models including new histopathological, digital, and molecular markers, with the goal of better directing clinical decisions to manage patients with PCa.
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- 2023
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29. Coexisting cancer stem cells with heterogeneous gene amplifications, transcriptional profiles, and malignancy are isolated from single glioblastomas
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De Bacco, Francesca, Orzan, Francesca, Crisafulli, Giovanni, Prelli, Marta, Isella, Claudio, Casanova, Elena, Albano, Raffaella, Reato, Gigliola, Erriquez, Jessica, D’Ambrosio, Antonio, Panero, Mara, Dall’Aglio, Carmine, Casorzo, Laura, Cominelli, Manuela, Pagani, Francesca, Melcarne, Antonio, Zeppa, Pietro, Altieri, Roberto, Morra, Isabella, Cassoni, Paola, Garbossa, Diego, Cassisa, Anna, Bartolini, Alice, Pellegatta, Serena, Comoglio, Paolo M., Finocchiaro, Gaetano, Poliani, Pietro L., and Boccaccio, Carla
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- 2023
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30. Assessment of drying conditions for storage of a yeast-based decolorization solution for application in textile industrial wastewater treatment plants
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Mendes, Marta, Cassoni, Ana C., Alves, Soraia, Moreira, Patrícia, Castro, Paula ML., and Pintado, Manuela E.
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- 2023
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31. Topography of Prostate Cancer Recurrence: A Single-centre Analysis of Salvage Radical Prostatectomy Specimens and Implications for Focal Salvage Treatments
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Giancarlo Marra, Giorgio Calleris, Emilia Massari, Elena Vissio, Luca Molinaro, Paola Cassoni, Daniele D'Agate, Marco Oderda, Massimo Valerio, Yannick Raskin, Steven Joniau, Mauro Papotti, and Paolo Gontero
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Salvage radical prostatectomy ,Recurrent prostate cancer ,Focal therapy ,Diseases of the genitourinary system. Urology ,RC870-923 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background: Most prostate cancer (PCa) recurrences after nonsurgical first-line treatment are managed with androgen deprivation therapy (ADT). When local treatment is indicated, salvage focal treatment (FT) may achieve outcomes similar to those after salvage radical prostatectomy (sRP), with lower morbidity. However, descriptions of the topography of PCa recurrence are scarce. Objective: To describe the characteristics and topography of recurrent PCa at sRP. Design, setting, and participants: We performed a review of the final pathology for consecutive men undergoing sRP at a single centre between 2007 and 2021. Outcome measurements and statistical analysis: Clinical and pathological outcomes and recurrence localisation (standardised map) were recorded. Suitability for salvage FT was evaluated using criteria defined a priori. Results and limitations: We included 41 men who underwent sRP after whole-gland treatment (82.9% primary radiotherapy). Of these, 68.3% had grade group ≥3 and 46.3% had pT3 disease, including nine men (22%) with seminal vesicle involvement >1 cm. The pN+ rate was 29.3%. Surgical margins were positive in 39% (mostly at the apex, 21.9%). PCa was located at
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- 2023
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32. Recovery of lignins with antioxidant activity from Brewer’s spent grain and olive tree pruning using deep eutectic solvents
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Cassoni, Ana C., Costa, Patrícia, Mota, Inês, Vasconcelos, Marta W., and Pintado, Manuela
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- 2023
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33. Protocol for the Extraction of Lignin from Brewer’s Spent Grain Using Deep Eutectic Solvents
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Cassoni, Ana C., primary, Costa, Patrícia, additional, and Pintado, Manuela, additional
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- 2023
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34. Dysplasia Grading of Colorectal Polyps Through Convolutional Neural Network Analysis of Whole Slide Images
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Perlo, Daniele, Tartaglione, Enzo, Bertero, Luca, Cassoni, Paola, Grangetto, Marco, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Su, Ruidan, editor, Zhang, Yu-Dong, editor, and Liu, Han, editor
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- 2022
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35. Topography of Prostate Cancer Recurrence: A Single-centre Analysis of Salvage Radical Prostatectomy Specimens and Implications for Focal Salvage Treatments
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Marra, Giancarlo, Calleris, Giorgio, Massari, Emilia, Vissio, Elena, Molinaro, Luca, Cassoni, Paola, D'Agate, Daniele, Oderda, Marco, Valerio, Massimo, Raskin, Yannick, Joniau, Steven, Papotti, Mauro, and Gontero, Paolo
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- 2023
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36. Coexisting cancer stem cells with heterogeneous gene amplifications, transcriptional profiles, and malignancy are isolated from single glioblastomas
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Francesca De Bacco, Francesca Orzan, Giovanni Crisafulli, Marta Prelli, Claudio Isella, Elena Casanova, Raffaella Albano, Gigliola Reato, Jessica Erriquez, Antonio D’Ambrosio, Mara Panero, Carmine Dall’Aglio, Laura Casorzo, Manuela Cominelli, Francesca Pagani, Antonio Melcarne, Pietro Zeppa, Roberto Altieri, Isabella Morra, Paola Cassoni, Diego Garbossa, Anna Cassisa, Alice Bartolini, Serena Pellegatta, Paolo M. Comoglio, Gaetano Finocchiaro, Pietro L. Poliani, and Carla Boccaccio
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CP: Cancer ,Biology (General) ,QH301-705.5 - Abstract
Summary: Glioblastoma (GBM) is known as an intractable, highly heterogeneous tumor encompassing multiple subclones, each supported by a distinct glioblastoma stem cell (GSC). The contribution of GSC genetic and transcriptional heterogeneity to tumor subclonal properties is debated. In this study, we describe the systematic derivation, propagation, and characterization of multiple distinct GSCs from single, treatment-naive GBMs (GSC families). The tumorigenic potential of each GSC better correlates with its transcriptional profile than its genetic make-up, with classical GSCs being inherently more aggressive and mesenchymal more dependent on exogenous growth factors across multiple GBMs. These GSCs can segregate and recapitulate different histopathological aspects of the same GBM, as shown in a paradigmatic tumor with two histopathologically distinct components, including a conventional GBM and a more aggressive primitive neuronal component. This study provides a resource for investigating how GSCs with distinct genetic and/or phenotypic features contribute to individual GBM heterogeneity and malignant escalation.
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- 2023
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37. POSTOPERATIVE CHANGES OF CONDYLAR POSITION AFTER ORTHOGNATHIC SURGERY: PRELIMINARY STUDY OF A COMPARISON BETWEEN THREE DIFFERENT TYPES OF MANDIBULAR FIXATION TECHNIQUES.
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Di Carlo, Daniele, primary, Cassoni, Andrea, additional, Veneroso, Chiara, additional, Galvano, Francesca, additional, Manganiello, Luigi, additional, Priore, Paolo, additional, Pucci, Resi, additional, and Valentini, Valentino, additional
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- 2024
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38. SOLITARY FIBROUS TUMOR OF THE HEAD AND NECK COMPARTMENT, OUR EXPERIENCE IN TREATMENT AND FOLLOW UP
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Galvano, F, primary, Cassoni, A, additional, Scivoletto, G, additional, Di Carlo, D, additional, Pucci, R, additional, Monaca, Marco Della, additional, and Valentini, V, additional
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- 2024
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39. Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries
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Glasbey, James C, Abbott, Tom EF, Ademuyiwa, Adesoji, Adisa, Adewale, AlAmeer, Ehab, Alshryda, Sattar, Arnaud, Alexis P, Bankhead-Kendall, Brittany, Abou Chaar, M K, Chaudhry, Daoud, Costas-Chavarri, Ainhoa, Cunha, Miguel F, Davies, Justine I, Desai, Anant, Elhadi, Muhammed, Fiore, Marco, Fitzgerald, James Edward, Fourtounas, Maria, Fowler, Alex James, Futaba, Kay, Gallo, Gaetano, Ghosh, Dhruva, Gujjuri, Rohan R, Hamilton, Rebecca, Haque, Parvez, Harrison, Ewen M, Hutchinson, Peter, Hyman, Gabriella, Isik, Arda, Jayarajah, Umesh, Kaafarani, Haytham MA, Kadir, Bryar, Lawani, Ismail, Lederhuber, Hans, Li, Elizabeth, Löffler, Markus W, Lorena, Maria Aguilera, Mann, Harvinder, Martin, Janet, Mazingi, Dennis, McClain, Craig D, McLean, Kenneth A, Meara, John G, Ramos-De La Medina, Antonio, Mengesha, Mengistu, Minaya, Ana, Modolo, Maria Marta, Moore, Rachel, Morton, Dion, Nepogodiev, Dmitri, Ntirenganya, Faustin, Pata, Francesco, Pearse, Rupert, Picciochi, Maria, Pinkney, Thomas, Pockney, 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Takahji, Mohammad Eyad, Hasan, Zein Fouad, Abduljalil, Aalaa, MAlhalabi, Nawras, Al Jammal, Mohamad Basher A, Alia, Diana N, Homsi, Muhannad, Masri, Joseph, Masri, Ruqaya J, Toutounji, Tayf, Al Aliwy, Marwan, Kabbani, Nasrullah, Kadoura, Lama, Sultan, Dana, Kassem, Luma Haj, Al-Naeb, Houmam Mohamad, Al-Hajjaj, Maher M, Alkhaleel, Wael, Swed, Sarya, Naal, Mohammad Yusuf, Tfankji, Salim, Almohammed, Mohammad Husein Rajab, Nabhan, Mohammad Hassan, Al-Mouakeh, Ahmad, Najjar, Mahfoud M, Alhashash, Ahmad, Ghazal, Ahmad, Alchallah, Mhd Obai, Alolabi, Homam, ElHomsi, Muhammad Omar, Rayes, Omar, Naem, Antoine, Al-Houssami, Salma MHD Mazen, Gawrieh, Bardisan S, Hamdan, Alaa, Hassan, Naya Talal, Hammed, Ali M, Elias, Elias George, Ahmad, Aline Ali, Knifaty, Mohammed Amr, Moussa, Ahmed M, Yabasin, Iddrisu Baba, Roan, Jun-Neng, Shih, Chao-Jung, Chen, Po Chuan, Lohsiriwat, Varut, Phupong, Vorapong, Techapongsatorn, Suphakarn, Lalchan, Avery M, Charles, Shane, Rim, Bouchahda, Bouhani, Malek, Ghalleb, Montassar, Chamakhi, Amine, Sebai, Amine, dahman, Nesrine Ben hadj, Ammar, Houssem, Said, Mohamed Amine, Kechiche, Nahla, Aghayeva, Afag, Dülgeroğlu, Onur, Ozben, Volkan, Aytac, Erman, Atasoy, Deniz, Arikan, Akif Enes, Kara, Halil, Dogan, Nasuh U, Bostanci, Asli, Turhan, Murat, Ozkan, Ozlenen, Dumlu, Ersin G, Menekşe, Ebru, Oter, Volkan, Piskin, Erol, Hasirci, Ismail, Colakoglu, Muhammet Kadri, Bostanci, Erdal Birol, Ozgun, Yigit Mehmet, Girgin, Behic, Erel, Serap, Demirel, Sibel, Yanik, Özge, Gecim, Ibrahim Ethem, Koc, Mehmet Ali, Akyol, Cihangir, Güner, Volkan, Konca, Can, Batioğlu, Figen, Hakseven, Musluh, Toptas, Tayfun, Aydin, Yener, Ulas, Ali B, Ince, Ilker, Altinel, Yuksel, Demirgan, Serdar, Meric, Serhat, Sevdi, Mehmet Salih, Ercetin, Candas, Ferahman, Sina, Aydin, Husnu, Dural, Ahmet Cem, Sahbaz, Nuri A, Yalkin, Omer, Sen, Murat, Isik, Ozgen, Yilmazlar, Ahmet Tuncay, Bisgin, Tayfun, Yigit, Banu, bayhan, Hüseyin, Buldanli, Mehmet Z, Gultekin, Murat, Cennet, Omer, Unal, Ertekin U, Çakici, Mehmet Çağlar, Iplikci, Ayberk, Yildirim, Asif, Ozgur, Ilker, Sen, Comert, Dincer, Muserref B, Erginöz, Ergin, Sanli, Ahmet Necati, Turna, Akif, Askar, Ahmet, Uludağ, Server Sezgin, Guldogan, Cem E, Ozmen, Mehmet M, Bozkurt, Mehmet A, özcan, Adem, Kara, Yasin, Kocataş, Ali, Guner, Ali, Sari, Ramazan, Memisoglu, Ecem, Saracoglu, Kemal T, Tosun, Yasin, Çetin, Kenan, Kalafat, Erkan, Taskiran, Cagatay, Vatansever, Dogan, Giray, Burak, Tatar, Ozan C, Köksal, Hande, Özkent, Mehmet Serkan, Ulutaş, Mehmet E, Hamarat, Mustafa B, Coskun, Bora, Abbasov, Aykhan, Altinsoy, Ezgi, Uprak, Tevfik Kivilcim, Saracoglu, Ayten, Ugurlu, M Umit, Kose, Emin, Ozgen, Utku, Sungurtekin, Ugur, Gonullu, Emre, Bayhan, Zulfu, Akin, Emrah, Mantoglu, Baris, Colak, Elif, Kucuk, Gultekin Ozan, Yuksel, Cemil, Aydin, Ferit, Dogan, Lutfi, Culcu, Serdar, Tufan, Aydin Eray, Citgez, Bulent, Akpinar, Göksever, Köksoy, Ülkü C, Ulgur, Hanife Seyda, Kalin, Murat, Ozkan, Omer Faruk, Yildirak, Muhammed Kadir, Atici, Semra Demirli, Salimoğlu, Semra, Abud, Burcin, Calik, Bulent, Kamer, Erdinc, Kebabci, Eyup, Uylas, Ufuk, Teker, Kenan, Cakmak, Guldeniz Karadeniz, Gultekin, Fatma Ayca, Xaviour, Okedi Francis, Isaac, Otolia, Gaston, Turinawe, Asiimwe, Daniel, Vahwere, Bienfait Mumbere, Sikakulya, Franck Katembo, Lule, Herman, Lugobe, Henry Mark, Lekuya, Hervé Monka, Namugenyi, Christine, Kiweewa, Ronald, Bosco, Muhangi, Yovenko, Ihor, Kopetskyi, Viacheslav, Maksymenko, Bogdan, Khan, Sabina A, Padvi, Amit Vasantrao, Serour, Mohamed A, Beigh, Shamim Ahmad, Elsayed, Hisham M, Mohamed, Awadelkarim O, Basappanavar, Vikram Somashekhar, Al-Wandi, Amna S, Khalil, Kareem S, Younis, Muhammad Umar, Al Saadi, Hayder S Abdulhadi, Heidan, Ginan K, Trehan, Ravi K, Davies, Justin, Ashcroft, James, Georgiades, Fanourios, Durrani, Amer J, Price, Stephen J, Wong, Kai Yuen, Agrawal, Amit, Seah, Matthew KT, Saad, Marwa M E, Segaren, Nicholas, Ghobrial, Marios, Balakrishnan, Anita, Forouhi, Parto, Khan, Wasim S, Wheeler, James, Schache, Andrew G, Katsikostas, Dimitrios P, Angelou, Dimitrios, Fell, Adam J, Madani, Rana, Dindyal, Shiva, Seraj, Shaikh S, Sharavanan, Premalatha, Iqbal, Muhammad R, Wong, Nicholas J, Lo, William B, Soon, Wai C, Hammouche, Dalia, Lee, Jonathan DE, Pachl, Max J, Alexander, Dinesh, Ahmad, Shoaib, Morley, Hannah L, Selwyn, David, Wareing, Jonathan, Oktseloglou, Vlasios, Bobak, Peter, Rampersad, Lisa S, Mohamed, Mazin, Kaur, Mandeep, Athanasiou, Antonios, Martin, Benjamin P, Jichi, Tarik S, Batchelor, Tim JP, Rozwadowski, Sophie, Maniarasu, Sarveen, Seyed-Safi, Parisah K, Kutuzov, Vladislav, Shah, Hemina B, Noton, Toby M, Dela Cruz, Nina Jyne Minette, Trehan, Neev, Tokidis, Evripidis, Byrne, Matthew H V, Winter, Stuart C, Pinto-Lopes, Rui, Pavithran, Aswathy, Khalifa, Ahmad O, Eardley, Nicola J, Ashour, Rami, Steinke, Jacqueline D, Esmail, Husayn D, Bence, Matthew N, Walters, Samuel T, Akinyemi, Tosin O, Lakpriya, Sathya, Moawad, Nader N, Panahi, Pedram, Lau, Joshua, McAleer, Stephen, Laoye, Adeyinka, Hussain, Abdulzahra Abdulsamad, Zafar, Muneeb, Elsheikh, Mohammed H, Shaerf, Daniel A, Soggiu, Fiammetta, Massoumi, Abaris, Gareb, Fahed, Yao, Mark W, Qamar, Mubasher A, Fang, Clarissa E H, Greenhalgh, Michael S, Hunt, Alexander, Oladeji, Emmanuel O, Benjamin, Miles W, Beak, Philip, Rae, Fraser J, Aithie, Joanna M S, Clarke, Gareth W J, Veeramootoo, Darmarajah, Ashman, Alex J, Kahka, Ehab E, Rafe, Tanvir, PATEL, PANNA K, Albirnawi, Hatim, Katory, Mark, Fisher, Ann, Amonkar, Sunil J, Rao, Pawan Kumar Dhruva, Holroyd, David J, Gkikas, Andreas, Newton, Lydia S, Kirk, Alan J B, Khalid, Ayesha, Ferguson, David, Stanier, Paul B, Shah, Vinay, El-Boghdadly, Kariem, Schizas, Alexis M P, ilyas, Minahi, George, Mark L, Gawad, Mothana, Groom, William D, Al-Azzawi, Mohammed, Ahluwalia, Julian CJ, Punjabi, Prakash P, Cheung, Fang Yi, Wilson, Michael D, Mitrofan, Claudia Gabriela, Malam, Yogeshkumar, Townson, Adam, Loubani, Mahmoud, Yau, Jih Dar, Seebah, Kevin, Akowuah, Enoch F, Pushpoth, Sreekumari R, Viswanath, Yirupaiahgari KS, ElSanhoury, Kareem, Chew, Misha, Walker, Thomas E, Elhassan, Almutasim Billah Elbagir, Belcher, Elizabeth, Goricar, Matej, majd, Hooman Soleymani, Knight, Dominic, Ismail, Lamiese, McKinnon, Chris, Ganau, Mario, Prokopenko, Max, Doshi, Neel S, Gkorila, Aikaterina, Sheikh, Nomaan A, Helm, Jessica R, Low, Mei Ken, Ogunfusika, Oluseyi Harold, Bisheet, George, Alhammali, Tariq, Arnob, Ahmed Showki, Singh, Jatinder, Allde, Emma L, Sambhwani, Sharan H, Dube, Manas, Gemmill, Elizabeth H, John, Joby, Gerogiannis, Ioannis N, Abuelgasim, Mona A A, Crate, Georgina, Holme, Thomas J, Nguyen, Anh T V, Ho, Michael W, Wade, Ryckie G, Hussain, Azar, Andrzejowski, Paul, Omakobia, Eugene, Eltayeb, Momin, Galabov, Tsanko P, Lee, Chung Yan Vernon, Nazir, Anum, Siaw, Oliver L, Ashford, Robert U, Boddy, Alex P, Ashmore, Christopher D, Shah, Snehadhar M, Gowers, Benjamin T V, Thekkinkattil, Dinesh K, Worku, Dawit, Harky, Amer, Talwar, Rishi, Sagoo, Harkiran K, Jambulingam, Periyathambi S, Smart, Christopher J, Doherty, Daniel T, Mastoridis, Sotiris, Kumar, Sidharth, Mahmoud, Rana, Solari, Francesca, Egan, Richard J, Barry, Jonathan D, Morrison, Jo, Davoudi, Kaveh, Hollyman, Marianne, Kelly, Andrew, Badenoch, Thomas F, pandanaboyana, sanjay, Critchley, Rebecca J, Sarodaya, Varun R, Sinnerton, Robert J H, Manickavasagam, Jaiganesh, Lindsay, Elizabeth F, Arora, Ankita, Hasan, Raashad, Liew, Ignatius, Ozua, Joshua, Kouritas, Vasileios, Collins, Rachael V, Lafford, George H, Moret, Charlie, Chean, Chung Shen, Horgan, Liam F, Aujayeb, Avinash, Siddique, Muhammad Harris, Navaratne, Lalin, Kotecha, Sanjeev, Bellato, Vittoria, Lewis, Sophia E, Ali, Muhammad Usman, Marson, Ben A, Craxford, Simon, Gajjar, Ketankumar, Theophilidou, Elena, Aboelmagd, Tariq, Khatkar, Harman, Awadallah, Mahmoud A, Blanco, Jose A, Chituku, Tsitsi G, Dixon, Oliver GB, sarveswaran, Janahan, Jones, Imogen S, Hammouche, Salah, Vijay, Vardhini, Ooi, Rucira, Karmarkar, Rahi, Khaleeq, Tahir, Bhatia, Mohit, Al-Khazaali, Badr L, Daadipour, Audrina, Mattar, Ahmed, Singhal, Tarun, Mahmoud, Moustafa Ibrahim, Glasbey, James, Nankivell, Paul C, Kalkat, Maninder S, Nour, Shahd, Beggs, Andrew D, Yershov, Danylo Y, Chughtai, Shafiq Ahmad, Youssef, Hesham, Norrish, Alan R, Mohammed, Mohammed M, Gwozdz, Adam M, Charalambous, Michalis P, Knight, Stephen R, McCaul, James A, Bridgman, Elsie A, El Sheikh, Mustafa, Ogunbowale, Akinsola, Wright, Evan O, Ahmed, Usama, Younus, Hafsa, Tincknell, Laura G, Weixing-Ho, Ken, Demetriou, Charis, Hussei, Mohammed, Reilly, John-Joe, Hormis, Anil P, Moug, Susan J, Anazor, Fitzgerald C, Horwell, Edward A, Neal-Smith, Gregory, McNamara, John M, Baryeh, Kwaku W, Bhatti, Khalid M, McKay, Joseph E, Cannoletta, Maria G, Perkins, Clare J, Gopalswamy, Sivakumar, Sheldon, Anna F, John, Joseph B, Mantle, Mark, Toia, Bogdan, Phillips, Andrew J, Al-Khyatt, Waleed, Lund, Jonathan N, Ammar, Ahmed Y, Yim, Guang H, Huntley, Daniel A, Daniels, Ian R, Valverde, Joao, Lumley, Edward David John, Walton, Thomas J, Raptis, Dimitri A, Dimitrokallis, Nikolaos, Nathan, Arjun, Motallebzadeh, Reza, Chowdhury, Shihab, Ahmed, Rezwan F A, Mirnezami, Reza, Szakmany, Tamas, Knight, Dominic J, Al-Azzani, Waheeb, Davies, Huw R, Ooi, Setthasorn Zhi Yang, Oo, Khaing K, Cullis, Paul S, Peng, Ed, Demetriades, Andreas K, Tambyraja, Andrew L, Poon, Michael TC, Brennan, Paul M, Oikonomou, Dimitrios, Newman, Samuel E, Le Blevec, Louise, Otify, Mohamed, Szatmary, Peter, Devkaran, Bhavesh, Sochorova, Dana, Sohrabi, Catrin, Sivaprakasam, Rajesh, Goh, Mingzheng Aaron, Atkinson, Kate V, Soares, Delvene, Prce, Daniela, Cann, Johnathon P, Grobbelaar, Amy C, Bradley, Rebecca, Strauss, Helen J, Taha, Ahmed, Minicozzi, Annamaria, Thakur, Bhaskar, Hanoun, Abdullah, Goru, Poornanand, Baumber, Rachel M, Sobti, Anshul S, Cross, George WV, Havenhand, Tom, Antoniou, George A, Chauhan, Govind Singh, Vokshi, Ismail, Mahmud, Ayesha, Albanese, Erminia, Evans, Daisy, Madhuri, Thumuluru Kavitha, Horsnell, Jonathan D, Zalmay, Pardis, Davies, Angharad J, Aljanadi, Firas, Jeganathan, Reubendra, Jones, Mark, Kakos, Christos, vidya, Raghavan, El-Ghobashy, Alaa, Habib, Ahmed M, Reid, Jeremy P, Rajgor, Harshadkumar Dhirajlal, Ahmed, Omar, Branagan, Graham, Mohamedahmed, Ali Yasen Y, Al-Sabbagh, Ali, Chetty, Govind, Kelty, Clive J, EL-Wajeh, Yasin A M, Tomlinson, James E, Rominiyi, Ola, Sinha, Saurabh, Saad, Sanad, Sahu, Banchhita, Charalampakis, Vasileios, Enemosah, Ibrahim, Williams, Simon J, Yaqoob, Hassan N, Laurent, Edward P, Moreau, Joshua L, Frostick, Rhiannon, Parwaiz, Hammad, Aboelmagd, Karim, Pournaras, Dimitri J, Hristova, Kalina H, Iyengar, Karthikeyan P, Mohamed, Muyed, Artioukh, Dmitri Y, Anwar, Sibtain, Hussein, Mostafa K A, Omogbehin, Tomisin S, Herron, Jonathan B T, Labib, Amir, Patel, Preemal, Marsden, Samuel C, Mehdian, Roshana, Santhirakumaran, Gowthanan, Smelt, Jeremy, Agarwal, Ketan, Lancerotto, Luca, Sahnan, Kapil, Shalhoub, Joseph, Donnelly, Liam J, Erridge, Simon, Chidambaram, Swathikan, Luo, Xun, Bansal, Sujesh, Ryan, Neil AJ, Smith, Alexander C D, Flatman, Michael, Wafaie, Imad, Malik, Muhammad Isfandyar Khan, Thumbadoo, Ruben P, Hussain, Shoaib F, Henein, Christin, Hamad, Yousif T, Belgaumkar, Ajay P, Bosanquet, David C, Kolias, Angelos G, Choi, David, Marcus, Hani J, Horsfall, Hugo RM Layard, Khan, Danyal Z, Sahni, Arun, Millward, Christopher P, Render, Luke, Truss, Adam, Elmoslemany, Tarek, Parmar, Chetan, Hanger, Joseph, Sheen, Jonathon, Rait, Jaideep S, Foreman, Jennifer, Marzouqa, Natalie, Fontalis, Andreas, Voulalas, Grigorios, CHEONG, Ryan Chin Taw, Dindyal, Sanjay, Arumugam, Sathyaseelan, Ward, Thomas R W, Stephens, Alastair S, Douka, Eleftheria, Abou-Foul, Ahmad K, McKay, Siobhan C, Kitchen, Mark O, Rees-Stoner, Oliver DJ, Balasubramanya, Supriya, Akhtar, Muhammad Adeel, Warwick, Andrew J, Pawar, Shweta, Dubey, Vivek, Al-Yaseen, Mustafa W, Williams, Christopher YK, Laird, Alexander, Krishna, Kandaswamy, Anyaugo, Ngozi S, Wuraola, Obafemi K, Odejinmi, Funlayo, Craven, Joanna M, West, Charlotte L, Barter, Reece A, Navaratnam, Devaraj M, Malik, Shahbaz S, Mahendran, Vimaladhithan, Zilvetti, Miguel, Lovegrove, Richard E, Board, Tim N, Zeiton, Moez, Sarwar, Safdar A, Duff, Sarah E, Hsabo, Elmuiz A, Nugur, Ashwani Kumar, Morris, Richard M, Lala, Anil K, Kwan-Feinberg, Rita O, Ross, Samuel W, Dressler, Jeremy A, Evans, Faye M, Wason, Shaun E L, Vogel, Keianna R, Wang, Joanna C, Sulciner, Megan L, Hirji, Sameer, Raoof, Mustafa, Wolff, Christopher J, kent, Ilan, Turan, Alparslan, Teixeira, Pedro G, Olson, Kristofor A, Patel, Neil D, Krishnamoorthy, Vijay, Moris, Dimitrios, Rice, Henry E, Gabr, Hesham, Satoskar, Savni R, Castater, Christine A, Jmaileh, Manal, Payne, Rachel E, Kwon, David S, Aarabi, Shahram, Escobar, Pedro F, Kronenfeld, Joshua P, Dalton, Michael K, Etchill, Eric W, Haut, Elliott R, Vervoort, Dominique, Dehal, Ahmed, McKenney, Mark, Elkbuli, Adel, Gosain, Ankush, Abdelsattar, Zaid M, Naunheim, Matthew R, Burks, Ciersten A, Zhou, Allen S, Heng, Marilyn, Abohashem, Shady, Lozano-Calderón, Santiago A, Reisenauer, Janani S, Mouawad, Nicolas J, Diehl, Thomas M, Eriksson, Evert A, Marwaha, Jayson S, Schroeppel, Thomas J, LaRocca, Christopher J, Chang, Grace H, Hassan, Romana, Nosanov, Lauren B, Rickard, Jennifer L, Avraham, Jacob B, Petrone, Patrizio, Sferra, Joseph J, Hadaya, Joseph, Mead, Brittany S, Hauptman, Jason S, Ahmad, Maleeha, Meola, Antonio, Chang, Steven D, Ko, Ara, Specht, Katherine E, Choudhry, Asad, Encalada, Ronald Zerna, Poggio, Juan L, Xing, Hang, Glass, Nina E, Hooker, Robert, Martins, Paulo N, Scott, Erin M, Bankhead, Brittany K, Giorgakis, Emmanouil, Nigh, Joe, Osborn, Tamara, Tay Lasso, Erika L, Beswick, Daniel M, Berndtson, Allison E, Kaups, Krista L, Chen, Lee-lynn, Farrell, Michael S, Boeck, Marissa A, Vaysburg, Dennis M, Kassam, Al-Faraaz, Turner, Kevin M, Dyas, Adam R, Coleman, Julia R, Folsom, Megan, Lam, Christopher M, Kumer, Sean C, Larson, Kelsey, Turner, Scott, Guidry, Christopher, Reddy, Madhuri, Berbel, German, Findley, Austin, Beahm, David, Bur, Andres, Marlor, Derek, Houndschell, Corey, Carver, Shea, Ulrich, Alissa, Bhutiani, Neal, DiChiacchio, Laura, Abdou, Hossam, Napolitano, Lena M, Ghebre, Rahel, Bass, Gary Alan, Kaplan, Lewis J, Martin, Niels D, Duffy, Caoimhe C, Abdelhamid, Sultan S, Daley, Brian J, Roland, Christina L, Dumas, Ryan P, Ban, Vin Shen, Rajesh, Aashish, Davies, Mark G, Purudappa, Prabhudev P, Walters, Camila B, Lin, Nicole, Ruzgar, Nensi M, Ullrich, Sarah J, Trostchansky, Ivan, Bonilla-Cal, Fernando, Castedo, Fabiola, Sobrero, Helena, Acuña, Gastón, Álvarez, Sofía M, Tarigo, Josefina, Carbajal, Ana C, Carbajal, Ana, Reyes, Antonio R, Al-Eryani, Fatima A, Alqousi, Nardeen N, Alattas, Zainab, Al-Saban, Rafat A, Al-Shehari, Mohammed M, ALHammadi, Nawal T, Shream, Sarah A, Al-Naggar, Hamza M, Al-Qalisi, Lina M, Nadeesh, Areej E, Al-Samawi, Hytham H, Bajjah, Hadeel M, AL-Ameri, Saba A, Albably, Jamal F, Ghannam, Rana A, Shamsan, Amatallah H, Meead, Abdullah A, Al- Zubaidi, Riham Q, Zulait, Mohammed A, Najeeb, Halah, Alsayadi, Musaed M, Al-Mashreqi, Seham K, Al-Jomai, Najla A, Alsayadi, Ramzi A, Al-Naggar, Moath M, Almarashi, Hassan A, Musaeed, Hasna M, Al-Raimi, Ibrahim M, Ghanem, Hossam N, Al-Zazay, Karim A, AL-Mahdi, Shehab A, Almontaser, Amatalaleem S, Savopoulos, Vanessa A S, Munthali, James, Kabongo, Kizito M C, Mushiwokufa, Willard, Ngulube, Allan, Ntoto, Crispin, Magama, Praise T, Dzinotyiwei, Daniel, Chivanga, Shelton K, Dube, Ngqabutho S, Sanchez, Ernesto C, Moyo, Assel T, Chengahomwe, Antony, Chinyowa, Simbarashe, Siamuchembu, Maphios, Bondera, Tafadzwa, and Mushawarima, Trust
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- 2022
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40. Effect of alkaline and deep eutectic solvents pretreatments on the recovery of lignin with antioxidant activity from grape stalks
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Cassoni, Ana C., Mota, Inês, Costa, Patrícia, Vasconcelos, Marta W., and Pintado, Manuela
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- 2022
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41. Systematic review on lignin valorization in the agro-food system: From sources to applications
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Cassoni, Ana C., Costa, Patrícia, Vasconcelos, Marta W., and Pintado, Manuela
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- 2022
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42. Screening for a more sustainable solution for decolorization of dyes and textile effluents using Candida and Yarrowia spp.
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Mendes, Marta, Cassoni, Ana C., Alves, Soraia, Pintado, Manuela E., Castro, Paula ML., and Moreira, Patrícia
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- 2022
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43. Genomic and Transcriptomic Profile of HNF1A-Mutated Liver Adenomas Highlights Molecular Signature and Potential Therapeutic Implications.
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Faini, Angelo Corso, Arruga, Francesca, Pinon, Michele, Bracciamà, Valeria, Vallone, Francesco Edoardo, Mioli, Fiorenza, Sorbini, Monica, Migliorero, Martina, Gambella, Alessandro, Carota, Damiano, Giraudo, Isaac, Cassoni, Paola, Catalano, Silvia, Romagnoli, Renato, Amoroso, Antonio, Calvo, Pier Luigi, Vaisitti, Tiziana, and Deaglio, Silvia
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KREBS cycle ,CHOLESTEROL metabolism ,GENETICS ,CELL migration ,FATTY acids ,NEOVASCULARIZATION - Abstract
Hepatocellular adenomas (HAs) are tumors that can develop under different conditions, including in patients harboring a germline mutation in HNF1A. However, little is known about the pathogenesis of such disease. This work aims to better define what mechanisms lie under the development of this condition. Six HAs were sampled from the liver of a 17-year-old male affected by diabetes and multiple hepatic adenomatosis harboring the heterozygous pathogenic germline variant c.815G>A, p.(Arg272His) in HNF1A, which has a dominant negative effect. All HAs were molecularly characterized. Four of them were shown to harbor a second somatic HNF1A variant and one had a mutation in the ARID1A gene, while no additional somatic changes were found in the remaining HA and normal parenchyma. A transcriptomic profile of the same HA samples was also performed. HNF1A biallelic mutations were associated with the up-regulation of several pathways including the tricarboxylic acid cycle, the metabolism of fatty acids, and mTOR signaling while angiogenesis, endothelial and vascular proliferation, cell migration/adhesion, and immune response were down-regulated. Contrariwise, in the tumor harboring the ARID1A variant, angiogenesis was up-modulated while fatty acid metabolism was down-modulated. Histological analyses confirmed the molecular data. Independently of the second mutation, energetic processes and cholesterol metabolism were up-modulated, while the immune response was down-modulated. This work provides a complete molecular signature of HNF1A-associated HAs, analyzing the association between specific HNF1A variants and the development of HA while identifying potential new therapeutic targets for non-surgical treatment. [ABSTRACT FROM AUTHOR]
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- 2024
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44. Jaw Reconstruction with Scapular Bone Flap and Prosthetic Implant Rehabilitation: A Comprehensive Systematic Review.
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Di Giorgio, Danilo, Nocini, Riccardo, Di Bartolomeo, Mattia, Fatiga, Matteo, Della Monaca, Marco, Priore, Paolo, Terenzi, Valentina, Battisti, Andrea, Cassoni, Andrea, and Valentini, Valentino
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RADIOISOTOPE brachytherapy ,DENTAL implants ,SCAPULA ,QUALITY of life ,DIGITAL technology ,FREE flaps - Abstract
A rising demand for prosthetic-driven jaw reconstruction is encountered in maxillo-facial surgery. The free scapula flap is a workhorse of cervico-facial reconstructions, but an implant-based prosthetic rehabilitation on this flap is a debated topic. A systematic review of the papers on this subject has been conducted on Embase, MEDLINE, and Cochrane libraries following PRISMA guidelines, in order to analyze the results described in the literature. A total of nine papers were eligible for inclusion, with 83 scapula flaps overall being used for an implant-based prosthetic rehabilitation. The mandible was the reconstructed jaw in 58.0% of the cases. Overall, 249 implants were positioned (mean 3.0 implant per flap) with a 3.6% implant failure rate. In 95.2% of the cases, delayed rehabilitation was performed. Radiotherapy and the timing of implant placement did not seem to influence implant failure. Only two papers analyzed the quality of life following the rehabilitation, highlighting a functional improvement. Scapula-based implant-prosthetic rehabilitation is a feasible technique that can also benefit from the new CAD/CAM technologies and digital workflows. Nonetheless, further studies focused on this topic and on its impact on the quality of life are needed in order to analyze risk factors and to optimize the outcomes. [ABSTRACT FROM AUTHOR]
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- 2024
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45. Impact of Caloric Restriction in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy: A Prospective Case Control Study
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Isabella Castellano, Francesco Gallo, Paola Durelli, Taira Monge, Maurizio Fadda, Jasna Metovic, Paola Cassoni, Fulvio Borella, Carlo Raucci, Monica Menischetti, Alessandra Beano, Giuseppe Migliaretti, and Concetta Finocchiaro
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breast cancer ,neoadjuvant chemotherapy ,caloric restriction diet ,body composition ,diet ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Background and aims: It is well established that caloric restriction (CR) may influence metabolic and hormonal factors involved in cancer development and progression. Recently, several studies have demonstrated that CR may have a favorable impact on the response to systemic therapy in breast cancer (BC) patients. However, there is a lack of data regarding the influence of CR during neoadjuvant chemotherapy (NACT). Our study’s primary aim was to evaluate CR’s impact on BC patients undergoing NACT. Secondly, we investigated the nutritional efficacy and safety of this intervention. Methods: We performed a prospective, case–control study in two breast units. A diet group consisting of 39 patients undergoing NACT and CR was enrolled in our study at the same time. CR consisted of a 30% reduction in caloric intake, which increased to 50% on the days before, during, and after the administration of chemotherapy. A control group of 60 patients that underwent the same treatment approach only followed the general dietary recommendations for BC according to WCRF guidelines. The diet group was monitored during the study for both dietary adequacy and weight trends. Results: CR combined with NACT showed a statistically significant therapeutic response in tumor size (OR 2.94, IC 1.07–8.01, p = 0.009) and lymph node status (OR 3.22, IC 1.22–8.56, p = 0.001) compared to NACT alone, even after the adjustment for all biological parameters. Our data also showed the efficacy and safety of this intervention in both anthropometric and biochemical analyses. Conclusions: Patients who adhered to CR showed a better response to NACT, both in the breast and in the axillary lymph nodes, compared to the patients in the control group. Furthermore, the CR diet combined with NACT showed good tolerance and safety.
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- 2023
- Full Text
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46. Dysplasia Grading of Colorectal Polyps Through Convolutional Neural Network Analysis of Whole Slide Images.
- Author
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Daniele Perlo, Enzo Tartaglione, Paola Cassoni, Luca Bertero, and Marco Grangetto
- Published
- 2021
- Full Text
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47. Unitopatho, A Labeled Histopathological Dataset for Colorectal Polyps Classification and Adenoma Dysplasia Grading.
- Author
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Carlo Alberto Barbano, Daniele Perlo, Enzo Tartaglione, Attilio Fiandrotti, Luca Bertero, Paola Cassoni, and Marco Grangetto
- Published
- 2021
- Full Text
- View/download PDF
48. A clinically compatible drug‐screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis
- Author
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Lucía Zhu, Diana Retana, Pedro García‐Gómez, Laura Álvaro‐Espinosa, Neibla Priego, Mariam Masmudi‐Martín, Natalia Yebra, Lauritz Miarka, Elena Hernández‐Encinas, Carmen Blanco‐Aparicio, Sonia Martínez, Cecilia Sobrino, Nuria Ajenjo, Maria‐Jesus Artiga, Eva Ortega‐Paino, Raúl Torres‐Ruiz, Sandra Rodríguez‐Perales, RENACER, Riccardo Soffietti, Luca Bertero, Paola Cassoni, Tobias Weiss, Javier Muñoz, Juan Manuel Sepúlveda, Pedro González‐León, Luis Jiménez‐Roldán, Luis Miguel Moreno, Olga Esteban, Ángel Pérez‐Núñez, Aurelio Hernández‐Laín, Oscar Toldos, Yolanda Ruano, Lucía Alcázar, Guillermo Blasco, José Fernández‐Alén, Eduardo Caleiras, Miguel Lafarga, Diego Megías, Osvaldo Graña‐Castro, Carolina Nör, Michael D Taylor, Leonie S Young, Damir Varešlija, Nicola Cosgrove, Fergus J Couch, Lorena Cussó, Manuel Desco, Silvana Mouron, Miguel Quintela‐Fandino, Michael Weller, Joaquín Pastor, Manuel Valiente, Adolfo de la Lama‐Zaragoza, Lourdes Calero‐Felix, Concepcion Fiaño‐Valverde, Pedro David Delgado‐López, Antonio Montalvo‐Afonso, Mar Pascual‐Llorente, Ángela Díaz‐Piqueras, SH Nam‐Cha, Cristina Barrena López, Gerard Plans Ahicart, Elena Martínez‐Saez, Santiago Ramón y Cajal, and Pilar Nicolás
- Subjects
drug‐screen ,metastasis ,organotypic cultures ,patient‐derived ,resistance ,Medicine (General) ,R5-920 ,Genetics ,QH426-470 - Abstract
Abstract We report a medium‐throughput drug‐screening platform (METPlatform) based on organotypic cultures that allows to evaluate inhibitors against metastases growing in situ. By applying this approach to the unmet clinical need of brain metastasis, we identified several vulnerabilities. Among them, a blood–brain barrier permeable HSP90 inhibitor showed high potency against mouse and human brain metastases at clinically relevant stages of the disease, including a novel model of local relapse after neurosurgery. Furthermore, in situ proteomic analysis applied to metastases treated with the chaperone inhibitor uncovered a novel molecular program in brain metastasis, which includes biomarkers of poor prognosis and actionable mechanisms of resistance. Our work validates METPlatform as a potent resource for metastasis research integrating drug‐screening and unbiased omic approaches that is compatible with human samples. Thus, this clinically relevant strategy is aimed to personalize the management of metastatic disease in the brain and elsewhere.
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- 2022
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49. INSM1 Expression in Breast Neoplasms with Neuroedocrine Features
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Metovic, Jasna, Castellano, Isabella, Marinelli, Eleonora, Osella-Abate, Simona, Sapino, Anna, Cassoni, Paola, and Papotti, Mauro
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- 2021
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50. PD50-08 CLINICALLY SIGNIFICANT MRI-NEGATIVE PROSTATE CANCER: A MATCHED-PAIRED ANALYSIS TO EVALUATE RADIOLOGICAL, HISTOLOGICAL AND MOLECULAR FEATURES
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Oderda, Marco, primary, Marquis, Alessandro, additional, Bertero, Luca, additional, Calleris, Giorgio, additional, Gatti, Marco, additional, Marra, Giancarlo, additional, Dematteis, Alessandro, additional, Ruggirello, Irene, additional, Vissio, Elena, additional, Faletti, Riccardo, additional, Cassoni, Paola, additional, and Gontero, Paolo, additional
- Published
- 2024
- Full Text
- View/download PDF
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