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134 results on '"Cassidy, Nigel J."'

17. sj-pdf-1-tej-10.1177_2041731420974147 – Supplemental material for Changes in the extracellular microenvironment and osteogenic responses of mesenchymal stem/stromal cells induced by in vitro direct electrical stimulation

Author

Kasama Srirussamee, Ruikang Xue, Mobini, Sahba, Cassidy, Nigel J, and Cartmell, Sarah H

Subjects
110599 Dentistry not elsewhere classified, FOS: Clinical medicine, FOS: Biological sciences, 69999 Biological Sciences not elsewhere classified
Abstract

Supplemental material, sj-pdf-1-tej-10.1177_2041731420974147 for Changes in the extracellular microenvironment and osteogenic responses of mesenchymal stem/stromal cells induced by in vitro direct electrical stimulation by Kasama Srirussamee, Ruikang Xue, Sahba Mobini, Nigel J Cassidy and Sarah H Cartmell in Journal of Tissue Engineering

Published
2021
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25. Direct electrical stimulation enhances osteogenesis by inducing Bmp2 and Spp1 expressions from macrophages and preosteoblasts

Author

Biotechnology and Biological Sciences Research Council (UK), Royal Thai Government, Srirussamee, Kasama, Mobini, Sahba, Cassidy, Nigel J., Cartmell, Sarah H., Biotechnology and Biological Sciences Research Council (UK), Royal Thai Government, Srirussamee, Kasama, Mobini, Sahba, Cassidy, Nigel J., and Cartmell, Sarah H.

Abstract

The capability of electrical stimulation (ES) in promoting bone regeneration has already been addressed in clinical studies. However, its mechanism is still being investigated and discussed. This study aims to investigate the responses of macrophages (J774A.1) and preosteoblasts (MC3T3-E1) to ES and the faradic by-products from ES. It is found that pH of the culture media was not significantly changed, whereas the average hydrogen peroxide concentration was increased by 3.6 and 5.4 µM after 1 and 2 hr of ES, respectively. The upregulation of Bmp2 and Spp1 messenger RNAs was observed after 3 days of stimulation, which is consistent among two cell types. It is also found that Spp1 expression of macrophages was partially enhanced by faradic by-products. Osteogenic differentiation of preosteoblasts was not observed during the early stage of ES as the level of Runx2 expression remains unchanged. However, cell proliferation was impaired by the excessive current density from the electrodes, and also faradic by-products in the case of macrophages. This study shows that macrophages could respond to ES and potentially contribute to the bone formation alongside preosteoblasts. The upregulation of Bmp2 and Spp1 expressions induced by ES could be one of the mechanisms behind the electrically stimulated osteogenesis.

Published
2019

30. Soilwater Conductivity Analysis to Date and Locate Clandestine Graves of Homicide Victims

Author

Pringle, Jamie K, Cassella, John P, Jervis, John R, Williams, Anna, Cross, Peter Andrew, Cassidy, Nigel J, Pringle, Jamie K, Cassella, John P, Jervis, John R, Williams, Anna, Cross, Peter Andrew, and Cassidy, Nigel J

Abstract

In homicide investigations, it is critically important that postmortem interval and postburial interval (PBI) of buried victims are determined accurately. However, clandestine graves can be difficult to locate; and the detection rates for a variety of search methods (ranging from simple ground probing through to remote imaging and near-surface geophysics) can be very low. In this study, simulated graves of homicide victims were emplaced in three sites with contrasting soil types, bedrock, and depositional environments. The long-term monthly in situ monitoring of grave soil water revealed rapid increases in conductivity up to 2 years after burial, with the longest study evidencing declining values to background levels after 4.25 years. Results were corrected for site temperatures and rainfall to produce generic models of fluid conductivity as a function of time. The research suggests soilwater conductivity can give reliable PBI estimates for clandestine burials and therefore be used as a grave detection method.

Published
2015

31. Combined time-lapse 3D GPR and resistivity investigations on simulated clandestine burials in complex urban environments

Author

Nuzzo, L, Pringle, JK, Jervis, J, CASSELLA, John, and Cassidy, Nigel, J

Abstract

The use of non-invasive geophysical methods in criminal in-vestigations is still relatively uncommon especially when com-pared to more conventional methods (e.g., aerial and remote sensing, cadaver dogs, excavation, etc.). Near-surface geophys-ical techniques, and particularly ground-penetrating radar (GPR), have been used with varying degrees of success to lo-cate clandestine graves, but multi-disciplinary studies have shown that cadaver detection is generally problematic after a long period of burial. Since the success of geophysical tech-niques is predominantly dependent upon the contrast between the target and host materials, there is a need for scientific re-search to try and quantify both target and site variables and how they may change over time which may therefore affect forensic burial detection.\ud This paper reports on recent near-surface high-frequency (450 and 900 MHz) GPR surveys over two contrasting simulated clandestine burial case studies in a difficult urban environ-ment: a simulated 12 year old adult burial and a recent juve-nile burial using contrasting materials. \ud Accurate GPR data processing, integration and 3D visualiza-tion (time-slice) techniques were essential to recognize and isolate the often subtle GPR anomalies over ‘graves’ in this complex, urban environment. GPR results compared well with bulk ground resistive anomaly locations, although GPR was higher resolution, better resolved the older burial and provid-ed a depth estimate to the buried target.

Published
2008

41. Foreword

Author

Cassidy, Nigel J., primary and Pringle, Jamie K., additional

Published
2010
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