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3. Mesoangioblasts at 20: From the embryonic aorta to the patient bed

Author

Cossu, G, Tonlorenzi, R, Brunelli, S, Sampaolesi, M, Messina, G, Azzoni, E, Benedetti, S, Biressi, S, Bonfanti, C, Bragg, L, Camps, J, Cappellari, O, Cassano, M, Ciceri, F, Coletta, M, Covarello, D, Crippa, S, Cusella-De Angelis, M, De Angelis, L, Dellavalle, A, Diaz-Manera, J, Galli, D, Galli, F, Gargioli, C, Gerli, M, Giacomazzi, G, Galvez, B, Hoshiya, H, Guttinger, M, Innocenzi, A, Minasi, M, Perani, L, Previtali, S, Quattrocelli, M, Ragazzi, M, Roostalu, U, Rossi, G, Scardigli, R, Sirabella, D, Tedesco, F, Torrente, Y, Ugarte, G, Cossu, Giulio, Tonlorenzi, Rossana, Brunelli, Silvia, Sampaolesi, Maurilio, Messina, Graziella, Azzoni, Emanuele, Benedetti, Sara, Biressi, Stefano, Bonfanti, Chiara, Bragg, Laricia, Camps, Jordi, Cappellari, Ornella, Cassano, Marco, Ciceri, Fabio, Coletta, Marcello, Covarello, Diego, Crippa, Stefania, Cusella-De Angelis, M Gabriella, De Angelis, Luciana, Dellavalle, Arianna, Diaz-Manera, Jordi, Galli, Daniela, Galli, Francesco, Gargioli, Cesare, Gerli, Mattia F M, Giacomazzi, Giorgia, Galvez, Beatriz G, Hoshiya, Hidetoshi, Guttinger, Maria, Innocenzi, Anna, Minasi, M Giulia, Perani, Laura, Previtali, Stefano C, Quattrocelli, Mattia, Ragazzi, Martina, Roostalu, Urmas, Rossi, Giuliana, Scardigli, Raffaella, Sirabella, Dario, Tedesco, Francesco Saverio, Torrente, Yvan, Ugarte, Gonzalo, Cossu, G, Tonlorenzi, R, Brunelli, S, Sampaolesi, M, Messina, G, Azzoni, E, Benedetti, S, Biressi, S, Bonfanti, C, Bragg, L, Camps, J, Cappellari, O, Cassano, M, Ciceri, F, Coletta, M, Covarello, D, Crippa, S, Cusella-De Angelis, M, De Angelis, L, Dellavalle, A, Diaz-Manera, J, Galli, D, Galli, F, Gargioli, C, Gerli, M, Giacomazzi, G, Galvez, B, Hoshiya, H, Guttinger, M, Innocenzi, A, Minasi, M, Perani, L, Previtali, S, Quattrocelli, M, Ragazzi, M, Roostalu, U, Rossi, G, Scardigli, R, Sirabella, D, Tedesco, F, Torrente, Y, Ugarte, G, Cossu, Giulio, Tonlorenzi, Rossana, Brunelli, Silvia, Sampaolesi, Maurilio, Messina, Graziella, Azzoni, Emanuele, Benedetti, Sara, Biressi, Stefano, Bonfanti, Chiara, Bragg, Laricia, Camps, Jordi, Cappellari, Ornella, Cassano, Marco, Ciceri, Fabio, Coletta, Marcello, Covarello, Diego, Crippa, Stefania, Cusella-De Angelis, M Gabriella, De Angelis, Luciana, Dellavalle, Arianna, Diaz-Manera, Jordi, Galli, Daniela, Galli, Francesco, Gargioli, Cesare, Gerli, Mattia F M, Giacomazzi, Giorgia, Galvez, Beatriz G, Hoshiya, Hidetoshi, Guttinger, Maria, Innocenzi, Anna, Minasi, M Giulia, Perani, Laura, Previtali, Stefano C, Quattrocelli, Mattia, Ragazzi, Martina, Roostalu, Urmas, Rossi, Giuliana, Scardigli, Raffaella, Sirabella, Dario, Tedesco, Francesco Saverio, Torrente, Yvan, and Ugarte, Gonzalo

Abstract

In 2002 we published an article describing a population of vessel-associated progenitors that we termed mesoangioblasts (MABs). During the past decade evidence had accumulated that during muscle development and regeneration things may be more complex than a simple sequence of binary choices (e.g., dorsal vs. ventral somite). LacZ expressing fibroblasts could fuse with unlabelled myoblasts but not among themselves or with other cell types. Bone marrow derived, circulating progenitors were able to participate in muscle regeneration, though in very small percentage. Searching for the embryonic origin of these progenitors, we identified them as originating at least in part from the embryonic aorta and, at later stages, from the microvasculature of skeletal muscle. While continuing to investigate origin and fate of MABs, the fact that they could be expanded in vitro (also from human muscle) and cross the vessel wall, suggested a protocol for the cell therapy of muscular dystrophies. We tested this protocol in mice and dogs before proceeding to the first clinical trial on Duchenne Muscular Dystrophy patients that showed safety but minimal efficacy. In the last years, we have worked to overcome the problem of low engraftment and tried to understand their role as auxiliary myogenic progenitors during development and regeneration.

Published
2023

5. Barbed pharyngoplasty for snoring: does it meet the expectations? a systematic review

Author

Moffa, A. (Antonio), Giorgi, L. (Lucrezia), Carnuccio, L. (Luca), Cassano, M. (Michele), Lugo, R. (Rodolfo), Baptista, P.M. (Peter M.), and Casale-Falcone, M. (Manuele)

Subjects
Barbed sutures, Snoring, Obstructive sleep apnea, Barbed pharyngoplasty
Abstract

To date, the use of barbed sutures for the surgical management of patients suffering from obstructive sleep apnea and snoring with retropalatal collapse and vibration has significantly increased. A systematic review was carried out, which included clinical studies that used barbed sutures for the treatment of snoring. A qualitative analysis, including six clinical studies, was conducted. Of these, five were studies on barbed pharyngoplasties, and one study involved a minimally invasive surgical procedure. The population consisted of 176 patients, aged 26 to 58 years old. Overall, the included studies showed a mean gain in the snoring Visual Analog Scale of 5.67 +/- 1.88, with a mean preoperative value of 8.35 +/- 1.17 and a postoperative value of 2.68 +/- 1.27. No major complications were described. Given the lack and heterogeneity of this evidence, the conclusion calls for being cautious. In carefully selected snorers and obstructive sleep apnea patients, the use of barbed sutures could represent a valid therapeutic strategy for snoring, ensuring a statistically significant improvement in the subjective parameters. Further studies on a larger scale that assess the role of barbed pharyngoplasties in snoring surgery and more extended follow-up studies are needed in order to confirm these promising results.

Published
2023

10. Chronic rhinosinusitis with nasal polyps: how to identify eligible patients for biologics in clinical practice

Author

Gelardi, M., Bocciolini, C., Notargiacomo, M., Schiavetti, I., Lingua, C., Pecoraro, P., Iannuzzi, L., Quaranta, V. A., Giancaspro, R., Ronca, G., Cassano, M., Ciprandi, G., Luca, Amorosa, Flavio, Arnone, Paolo, Luperto, Pasqua Irene Sciancalepore, Luigi, Alonzi, Marilena, Tomaiuolo, Alessandro Maselli Del Giudice, Anna, Miglietta, Veronica, Seccia, Giovanni Giulio Sulis, Cristiano, Caruso, Valentina, Rossi, Ciofalo, Andrea, Consagra, Calogera, Antonio, Palma, and Michela, Mancini

Subjects
Adult, Biological Products, nasal polyp score, chronic rhinosinusitis with nasal polyps, biological therapy, CCG, SNOT-22, adult, humans, quality of life, biological products, nasal polyps, rhinitis, sinusitis, General Energy, Nasal Polyps, Otorhinolaryngology, Quality of Life, Humans, Sinusitis, Rhinitis
Abstract

This study compared three severity measures for chronic rhinosinusitis with nasal polyps (CRSwNP). The outcome was to identify patients who are eligible for biological therapy.330 adult patients with CRSwNP were examined. Nasal polyp score (NPS), sinonasal outcome test (SNOT-22) and clinical-cytological grading (CCG) were compared. Clinical history, past surgery and asthma control test were also considered.Only 45 (13.6%) patients had a contextual positivity to the three severity measures. The concordance among tests was slight/fair. Patients with severe disease (all tests positive) had more impaired parameters. The mixed cytotype (OR = 4.07), nasal obstruction (OR = 10.06), post-nasal drip (OR = 1.98), embarrassment (OR = 2.53) and difficulty falling asleep (OR = 1.92) were significantly associated with severe CRSwNP.To identify candidates for biological therapy, the contextual use of NPS, SNOT-22 and CCG is preferable. In this way, global assessment of CRSwNP, including morphology, inflammation, comorbidity, symptoms and quality of life is possible.Rinosinusite cronica con poliposi nasale: come individuare i candidati alla terapia biologica nella pratica clinica.Questo studio confrontava 3 differenti indici di gravità della rinosinusite cronica con poliposi nasale (RSCcPN). L’obbiettivo era individuare i pazienti eleggibili al trattamento con farmaci biologici.330 pazienti adulti con RSCcPN erano arruolati. Tutti i pazienti venivano valutati mediante nasal polyp score (NPS), sinonasal outcome test (SNOT-22) e clinical-cytological grading (CCG). Inoltre erano considerati la storia clinica, i pregressi interventi chirurgici ed il controllo dell’asma.Solamente 45 (13,6%) pazienti avevano i 3 indici positivi. La concordanza tra i 3 indici era bassa/modesta. I pazienti con la malattia grave (contestuale positività a tutti i test) avevano peggiori parametri. Il citotipo misto (OR = 4,07), l’ostruzione nasale (OR = 10,06), il post-nasal drip (OR = 1,98), il disagio (OR = 2,53), e la difficoltà ad addormentarsi (OR = 1,92) erano significativamente associati con la malattia grave.È preferibile utilizzare contemporaneamente i 3 test per individuare i pazienti candidati alla terapia biologica. In questo modo si può avere un quadro generale della malattia, comprendente la morfologia dei polipi, lo stato di infiammazione, le comorbidità, i sintomi e la qualità della vita.

Published
2021

14. Clinical-Cytological-Grading and phenotyping in patients with chronic rhinosinusitis with nasal polyps: the relevance in clinical practice

Author

Gelardi, M., Porro, G., Quaranta, V., Quaranta, N., Cassano, M., Ciprandi, G., Luigi, Alonzi, Arturo Arnone Caruso, Francesco, Barbara, Michele, Barbara, Paolo, Castelnuovo, Giovanna, Ciancio, Ciofalo, Andrea, Michele, Curatolo, Nicola De Candia, Carlo De Luca, Valentina De Robertis, Valentina Di Benedetto, Valeria, Fiore, Lucia, Iannuzzi, Clara, Imperatore, Cristiano, Lingua, Giuseppe, Lombardo, Alberto, Macchi, Michela, Mancini, Alessandro Maselli del Giudice, Patrizia, Mola, Mario, Notargiacomo, Antonio, Palma, Piero, Pecoraro, Giuseppe, Pellitteri, Krizia, Piccininni, Massimo, Rinaldi, and Valentina, Rossi. Study Group On CRSwNP I.

Subjects
Pulmonary and Respiratory Medicine, Adult, Male, Allergy, medicine.medical_specialty, congenital, hereditary, and neonatal diseases and abnormalities, real-world, cytological phenotype, Chronic rhinosinusitis, lcsh:Medicine, Comorbidity, chronic rhinosinusitis with nasal polyps, Nasal Polyps, Internal medicine, clinical-cytological-grading, Eosinophilic, Outcome Assessment, Health Care, medicine, Hypersensitivity, Prevalence, Humans, Nasal polyps, Sinusitis, Grading (tumors), Asthma, Retrospective Studies, Aspirin, business.industry, lcsh:R, Cell Biology, Middle Aged, medicine.disease, asthma, comorbidity, Clinical Practice, Cross-Sectional Studies, Phenotype, Italy, Chronic Disease, Female, Cardiology and Cardiovascular Medicine, business
Abstract

Chronic rhinosinusitis (CRS) includes two main phenotypes: without nasal polyps (CRSsNP) and with nasal polyps (CRSwNP). CRSwNP may be associated with comorbidity, mainly concerning asthma, aspirin intolerance, and allergy. CRSwNP patients may also be evaluated by clinical-cytological grading (CCG). The current study investigated the prevalence and characteristics of the different CCG and phenotypes in CRSwNP outpatients examined in clinical practice. This retrospective cross-sectional study enrolled 791 consecutive CRSwNP outpatients (424 males, mean age 48.8 years). In the total population, asthma was a common comorbidity (30.8%) as well as aspirin intolerance (24.8%), and allergy (50.8%). As concerns CCG-grading, 210 (26.5%) outpatients had low-grade, 366 (46.3%) medium, and 215 (27.2%) high. As regards cytological phenotypes, 87 (11%) had neutrophilic type, 371 (46.3%) eosinophilic, 112 (14.2%) mast cell, and 221 (27.9%) mixed. High-grade CCG was significantly associated with more frequent asthma, aspirin intolerance, allergy, recurrent surgery, and mixed cytological phenotype. Low-grade CCG was characterized by fewer comorbidities and operations, and neutrophilic phenotype. Therefore, the present study confirmed that CCG is a useful tool in the management of outpatients with CRSwNP. CRSwNP is frequently associated with asthma, aspirin intolerance, and allergy comorbidity. High-grade CCG is frequently characterized by a mixed cytological phenotype, thus, by more severe progress. These real-world outcomes underline that CRSwNP deserves adequate attention for careful management and optimal identification of the best-tailored therapy; CCG and cytological phenotyping could be fruitful tools in clinical practice. Asthma and aspirin intolerance should be adequately investigated in all CRS patients.

Published
2020

15. The hyperchromatic supranuclear stria corresponds to the golgi apparatus in nasal ciliated cells

Author

Gelardi M., Guerra L., Giangregorio N., Cassano M., Favia M., and Ciprandi G.

Subjects
The hyperchromatic supranuclear stria corresponds to the Golgi apparatus nasal ciliated cells, mental disorders, otorhinolaryngologic diseases, sense organs, eye diseases, nervous system diseases
Abstract

The hyperchromatic supranuclear stria corresponds to the Golgi apparatus in nasal ciliated cells (Letter to the Editor)

Published
2020

23. Surgical treatment of nasal septal perforations: SIR (Italian Society of Rhinology) experts opinion|Tratamiento quirúrgico de las perforaciones del tabique nasal: una opinión de los expertos de la SIR (Sociedad Italiana de Rinología)

Author

Passali, D, Spinosi, Mc, Salerni, L, Cassano, M, Rodriguez, H, Passali, Fm, and Bellussi, Lm

Subjects
Nasal septum, Cirugía de las perforaciones del tabique nasal, Nasal septal perforation surgery, Nasal septal perforations, Perforaciones del tabique nasal, Tabique nasal, Humans, Italy, Nasal Septal Perforation, Self Report, Societies, Medical, Attitude of Health Personnel, Attitude to Health, Otolaryngology, Settore MED/31 - Otorinolaringoiatria, Medical, Societies
Published
2017

32. Efficacy and tolerability of a new medical device in nasal polyposis treatment

Author

Passali, Fm, Topazio, D, Bellussi, L, Caruso, G, Cassano, M, Cassano, P, De Benedetto, M, Leone, C, Ottaviani, F, Passali, G, Passali, V, Piemonte, M, Rapino, G, Salami, A, Scarano, E, Vesperini, G, and Passali, D

Subjects
Glycyrrhetic acid, HMGB1, Nasal polyposis, Settore MED/31 - Otorinolaringoiatria
Published
2013

34. Migrating tumor cells and muscle wasting

Author

Berardi, E, Cassano, M, Ortiz, C, Costamagna, Domiziana, Floris, G, Wozniak, A, Debiec Rychter, M, Schoffscki, P, and Sampaolesi, M.

Published
2012

41. [Clinical evaluation of the efficacy of Salsomaggiore (Italy) thermal water in the treatment of rhinosinusal pathologies]

Author

Passali, Desiderio, Lauriello, M, Passali, Gc, Passali, Fm, Cassano, M, Cassano, P, and Bellussi, LUISA MARIA

Subjects
Adult, Male, Nebulizers and Vaporizers, Mineral Waters, Humans, Case-Control Studies, Rhinitis, Chronic Disease, Sinusitis, Administration, Inhalation, Italy, Female, Settore MED/31 - Otorinolaringoiatria, Inhalation, Administration
Abstract

Aim of the research was to demonstrate the efficacy of a treatment with thermal water as nasal spray (Salsomaggiore Italy) vs saline on chronic rhinosinusitis with/out nasal polyps.55 patients affected by chronic rhinosinusitis with/out I degree nasal polyposis randomised into two groups were enrolled. 30 patients of the study group were treated with thermal water nasal spray 4 times/day for 4 weeks. 25 patients of the control group were treated, with the same protocol, with saline. At the beginning and at the end of the study, in all the subjects the clinical history, objective examination and the instrumental analysis of nasal functions by active anterior rhinomanometry, mucociliary transport (MCT) time determination and nasal cytology were performed.At the end of the treatment patients in the study group showed an improvement statistically significant, with respect to the control group, of headache, rhinorrea and hiposmia. Significant differences were also observed between the study and control group concerning objective examination (nasal mucosa appearance and crusts) and instrumental analysis (rhinomanometric values and mucociliary transport times). Nasal cytology (epithelial and goblet cells, neutrophils, eosinophils, bacteria) improved in both groups without any statistical difference.Thermal water (Salsomaggiore Italy) nasal spray showed a greater efficacy with respect to saline in the treatment of patients affected by chronic rhinosinusitis.

Published
2008

50. Problematic mobile phone use in adolescence: A cross-sectional study

Author

Martinotti, Giovanni, Villella, Corrado, Di Thiene, D, Di Nicola, Marco, Bria, Pietro, Conte, Gianluigi, Cassano, M, Petruccelli, F, Corvasce, N, Janiri, Luigi, La Torre, G., Conte, Gianluigi (ORCID:0000-0002-8541-6923), Janiri, Luigi (ORCID:0000-0002-1633-9418), Martinotti, Giovanni, Villella, Corrado, Di Thiene, D, Di Nicola, Marco, Bria, Pietro, Conte, Gianluigi, Cassano, M, Petruccelli, F, Corvasce, N, Janiri, Luigi, La Torre, G., Conte, Gianluigi (ORCID:0000-0002-8541-6923), and Janiri, Luigi (ORCID:0000-0002-1633-9418)

Abstract

Aim: In recent years, mobile phone use has become increasingly common among Italian youth, while a growing scientific literature has been identifying the occurrence of a problematic mobile phone use which seems to share some features of other conditions often referred to as behavioural addictions. The study aimed to assess the prevalence of problematic mobile phone use in a population of Italian adolescents and its association with other behavioural addictions. Subjects and methods: The Mobile Addiction Test (MAT) was administered to 2,790 high school students from Barletta, an Italian town, together with the South Oaks Gambling Screen-Revised for Adolescents (SOGS-RA), the Compulsive Buying Scale (CBS), the Internet Addiction Test (IAT), the Exercise Addiction Inventory (EAI), the Work Addiction Risk Test (WART). Results: MAT scores fitted a Gaussian distribution model. Scores ≥ 17 was found as a cut-off value over which identifying problematic mobile phone users. Overall prevalence of problematic mobile phone use was 6.3%; this condition was associated with other behavioural addictions like compulsive buying. Conclusion: Problematic mobile phone use in adolescence should become a public health issue, and it could be a cause of health problems and social costs.

Published
2011

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