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5. Clinical Utility of 18F-FDG PET/CT in the Work-up of Children with Uveitis.

Author

Bazewicz, M., Makhoul, D., Goffin, L., El Mouden, J., Judice M. Relvas, L., Caspers, L., Draganova, D., Postelmans, L., Garcia, C., and Willermain, F.

Subjects
IRIDOCYCLITIS, UVEITIS, POSITRON emission tomography, CHILD patients, POSITRON emission tomography computed tomography, PETS
Abstract

To evaluate 18F-fluorodeoxyglucose Positron Emission Tomography/ultra low dose Computed Tomography (18F-FDG PET/ ULD CT) in the work-up of pediatric uveitis. Retrospective study of 12 children followed for uveitis who underwent whole body 18F-FDG PET/ULD CT between 2011 and 2019. The average age of the patients was 11 years. A total of 100% of patients presented with bilateral uveitis, 50% had panuveitis and 92% had various choroidal involvement. Relevant information for diagnosis was provided in four patients. 5/12 had an abnormal 18F-FDG uptake. Of these, three patients had pathognomonic images of active granulomatous diseases. Three patients underwent PET CT-guided biopsies of which two were positive for sarcoidosis. 18F-FDG PET/CT provided important information for final diagnosis in approximately 30% (4/12) of pediatric patients with bilateral uveitis. Whole body FDG PET/ULD CT can contribute to the final diagnosis thanks to pathognomonic image of active granulomatous disease and/or by indicating metabolically active site of biopsy that would not be visualized in thorax CT. [ABSTRACT FROM AUTHOR]

Published
2023
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6. Collaborative Ocular Tuberculosis Study Consensus Guidelines on the Management of Tubercular Uveitis—Report 2: Guidelines for Initiating Antitubercular Therapy in Anterior Uveitis, Intermediate Uveitis, Panuveitis, and Retinal Vasculitis

Author

Agrawal, R., Testi, I., Bodaghi, B., Barisani-Asenbauer, T., Mccluskey, P., Agarwal, A., Kempen, J. H., Gupta, A., Smith, J. R., de Smet, M. D., Yuen, Y. S., Mahajan, S., Kon, O. M., Nguyen, Q. D., Pavesio, C., Gupta, V., Agarwal, M., Aggarwal, A., Aggarwal, K., Agrawal, M., Al-Dhibi, H., Androudi, S., Asyari, F., Balasundaram, M. B., Murthy, K. B., Baglivo, E., Banker, A., Bansal, R., Basu, S., Behera, D., Biswas, J., Carreno, E., Caspers, L., Chee, S. P., Chhabra, R., Cimino, L., Concha del Rio, L. E., Cunningham, E. T., Land Curi, A. L., Das, D., Davis, J., Desmet, M., Denisova, E., Denniston, A. K., Errera, M. -H., Fonollosa, A., George, A., Goldstein, D. A., Crosier, Y. G., Gunasekeran, D. V., Gurbaxani, A., Invernizzi, A., Isa, H. M., Islam, S. M. D., Jones, N., Katoch, D., Khairallah, M., Khosla, A., Kramer, M., Kumar, A., La Distia Nora, R., Lee, R., Lowder, C., Luthra, S., Mahendradas, P., Makhoul, D., Mazumdar, S., Mehta, S., Miserocchi, E., Mochizuki, M., Mohamed, O. S., Muccioli, C., Munk, M. R., Murthy, S., Narain, S., Nascimento, H., Neri, P., Nguyen, M., Okada, A. A., Ozdal, P., Palestine, A., Pichi, F., Raje, D., Rathinam, S. R., Rousselot, A., Schlaen, A., Sehgal, S., Nida Sen, H., Sharma, A., Sharma, K., Shoughy, S. S., Singh, N., Singh, R., Soheilian, M., Sridharan, S., Thorne, J. E., Tappeiner, C., Teoh, S., Tognon, M. S., Tugal-Tutkun, I., Tyagi, M., Uy, H., Vasconcelos Santos, D. V., Valentincic, N. V., Westcott, M., Yanai, R., Alvarez, B. Y., Zahedur, R., Zierhut, M., and Xian, Z.

Published
2021

7. Collaborative Ocular Tuberculosis Study Consensus Guidelines on the Management of Tubercular Uveitis—Report 1: Guidelines for Initiating Antitubercular Therapy in Tubercular Choroiditis

Author

Agrawal, R., Testi, I., Mahajan, S., Yuen, Y. S., Agarwal, A., Kon, O. M., Barisani-Asenbauer, T., Kempen, J. H., Gupta, A., Jabs, D. A., Smith, J. R., Nguyen, Q. D., Pavesio, C., Gupta, V., Agarwal, M., Aggarwal, A., Aggarwal, K., Agrawal, M., Al-Dhibi, H., Androudi, S., Asyari, F., Balasundaram, M. B., Murthy, K. B., Baglivo, E., Banker, A., Bansal, R., Basu, S., Behera, D., Biswas, J., Bodaghi, B., Carreno, E., Caspers, L., Chee, S. P., Chhabra, R., Cimino, L., Concha del Rio, L. E., Cunningham, E. T., Land Curi, A. L., Das, D., Davis, J., Desmet, M., Denisova, E., Denniston, A. K., Errera, M. -H., Fonollosa, A., George, A., Goldstein, D. A., Crosier, Y. G., Gunasekeran, D. V., Gurbaxani, A., Invernizzi, A., Isa, H. M., Islam, S. M., Jones, N., Katoch, D., Khairallah, M., Khosla, A., Kramer, M., Kumar, A., La Distia Nora, R., Lee, R., Lowder, C., Luthra, S., Mahendradas, P., Makhoul, D., Mazumdar, S., Mccluskey, P., Mehta, S., Miserocchi, E., Mochizuki, M., Mohamed, O. S., Muccioli, C., Munk, M. R., Murthy, S., Narain, S., Nascimento, H., Neri, P., Nguyen, M., Okada, A. A., Ozdal, P., Palestine, A., Pichi, F., Raje, D., Rathinam, S. R., Rousselot, A., Schlaen, A., Sehgal, S., Sen, H. N., Sharma, A., Sharma, K., Shoughy, S. S., Singh, N., Singh, R., Soheilian, M., Sridharan, S., Thorne, J. E., Tappeiner, C., Teoh, S., Tognon, M. S., Tugal-Tutkun, I., Tyagi, M., Uy, H., Vasconcelos Santos, D. V., Valentincic, N. V., Westcott, M., Yanai, R., Alvarez, B. Y., Zahedur, R., and Zierhut, M.

Published
2021

8. Current ophthalmology practice patterns for syphilitic uveitis

Author

Genevieve, F Oliver, Roy, M Stathis, João, M Furtado, Tiago, E Arantes, Peter, J McCluskey, Janet, M Matthews, Justine, R Smith, Accorinti, M, Adan, A, Agarwal, A, Alieldin, R, Allegri, P, Alvarez, C, Androudi, S, Arevalo, Jf, Aubin, Mj, Babu, K, Barisani-Asenbauer, T, Barron, Z, Basu, S, Biswas, J, Bodaghi, B, Bursztyn, M, Jose Capella, M, Caspers, L, Chee, Sp, Cimino, L, Colombero, D, Concha Del Rio LE, Curi, All, Dacey, M, Das, D, Davis, J, Edwar, L, Errera, Mh, Finamor, Lp, Fonollosa, A, Fortin, E, Fraser-Bell, S, Funk, M, Garcia-Serrano, Jl, Garweg, J, Garza-Leon, M, George, A, Goldstein, D, Goto, H, Gottlieb, C, Guedes, M, Guex-Crosier, Y, Gurbaxani, A, Henry, C, Hooper, C, Hovland, T, Hwang, Ys, Invernizzi, A, Isa, H, Jodar-Marquez, M, Kansupada, K, Kawali, A, Kempen, Jh, Khairallah, M, Krag, S, Kuijpers, R, Laithwaite, J, Lee, St, Lefebvre, P, Lehoang, P, Lobo, Am, Mahendradas, P, Mccluskey, P, Mili-Boussen, I, Mochizuki, M, Moschos, M, Nascimento, H, Nguyen, J, Nguyen, Qd, O'Keefe, G, Oli Mohamed, S, Ozdal, P, Menendez Padron MI, Palestine, A, Paroli, Mp, Pavesio, C, Pichi, F, Pleyer, U, Przezdziecka-Dolyk, J, Rao, N, Rathinam, S, Ribeiro, M, Roy, M, O P, Sabat, Sandhu, Hs, Sittivarakul, W, Smith, J, Smith, W, Somkijrungroj, T, Sood, A, Suelves, A, Tay-Kearney, Ml, Teuchner, B, Thorne, J, Trittibach, P, Tugal-Tutkun, I, Unzueta-Medina, Ja, Santos Valadares ED, Van Os, L, Wells, J, Alvarez, By, Young, S, Zierhut, M., and Surgical clinical sciences

Subjects
Adult, Male, syphilis, Penicillins, EYE, Eye Infections, Bacterial, Uveitis, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Copyright policy, Surveys and Questionnaires, medicine, Humans, 030212 general & internal medicine, Practice Patterns, Physicians', Referral and Consultation, Societies, Medical, Retrospective Studies, Medicine(all), Practice patterns, business.industry, Middle Aged, medicine.disease, infection, Sensory Systems, Anti-Bacterial Agents, Syphilis Serodiagnosis, 3. Good health, Ophthalmology, inflammation, eye, uveitis, 030221 ophthalmology & optometry, Optometry, Female, Syphilis, business
Abstract

BackgroundSyphilitic uveitis is re-emerging alongside the systemic infection. In July 2017, an international group of uveitis-specialised ophthalmologists formed the International Ocular Syphilis Study Group to define current practice patterns.Methods103 Study Group members based in 35 countries completed a 25-item questionnaire focused on case load, clinical presentations, use and interpretation of investigations, treatment and clinical indicators of poor prognosis.ResultsMembers managed a mean of 6.1 patients with syphilitic uveitis in clinics that averaged 707 annual cases of uveitis (0.9%); 53.2% reported increasing numbers over the past decade. Patients presented to more members (40.2%) during secondary syphilis. Uveitis was usually posterior (60.8%) or pan (22.5%); complications included optic neuropathy, macular oedema and posterior synechiae. All members diagnosed syphilitic uveitis using serological tests (simultaneous or sequential testing algorithms), and 97.0% routinely checked for HIV co-infection. Cerebrospinal fluid (CSF) analysis was ordered by 90.2% of members, and 92.7% took uveitis plus Venereal Disease Research Laboratory test (VDRL) or fluorescent treponemal antibody absorption test (FTA-ABS) to indicate neurosyphilis. Patients were commonly co-managed with infectious disease physicians, and treated with penicillin for at least 10–14 days, plus corticosteroid. Features predicting poor outcome included optic neuropathy (86.3%) and initial misdiagnosis (63.7%). Reasons for delayed diagnosis were often practitioner-related. 82.5% of members tested every patient they managed with uveitis for syphilis.ConclusionThis comprehensive report by an international group of uveitis-specialised ophthalmologists provides a current approach for the management of syphilitic uveitis.

Published
2019
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17. Neurosyphilis cerebrospinal fluid findings in patients with ocular syphilis.

Author

Bazewicz, M., Lhoir, S., Makhoul, D., Libois, A., Van den Wijngaert, S., Caspers, L., and Willermain, F.

Subjects
NEUROSYPHILIS, CEREBROSPINAL fluid, SYPHILIS, CENTRAL nervous system
Abstract

Purpose: To evaluate neurosyphilis cerebrospinal fluid (CSF) findings and initial ophthalmic manifestations in patients with syphilitic uveitis.Methods: We retrospectively reviewed the records of CSF analysis of 14 patients with syphilitic uveitis with treponemal analysis - chemiluminescent immunoassay and TPHA- and non-treponemal analysis - Rapid Plasma Reagin test - RPR.Results: 86% were males and 43% HIV+. Ocular signs of syphilis lead to the diagnosis of syphilis in 78% of patients. Typical syphilitic uveitis presentations included: acute syphilitic posterior placoid chorioretinitis (50% of patients), retinitis (21% of patients) and punctate inner retinitis (7% of patients). 57% of patients had definite neurosyphilis by the CDC criteria, while 71% had CSF abnormalities suggestive of central nervous system involvement.Conclusion: Based on international guidelines, the frequent CSF abnormalities found in syphilitic uveitis patient supports the diagnosis of neurosyphilis in a majority of patients. [ABSTRACT FROM AUTHOR]

Published
2021
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30. Atypical Cogan's syndrome. Based on a case

Author

Nandu, A., Paul Salu, Caspers, L., Frans Gordts, Jacques Sennesael, and Specialiteiten (KNO, Dermatologie, Oftalmologie, Psychiatrie)

Subjects
Vasculitis, Cogan's syndrome, Vestibular Diseases, atypical, atypique, Humans, Female, Syndrome, Middle Aged, Uveitis, Anterior, Cogan
Abstract

[Atypical Cogan's syndrome. Based on a case][Article in French] Nandu A, Salu P, Caspers L, Gordts F, Sennesael J. Service d'Ophtalmologie, Hôpital Universitaire AZ--VUB, Vrije Universiteit Brussel. Cogan's syndrome is a systemic inflammatory disease that associates typical (interstitial keratitis) and atypical (such as anterior uveitis) ocular manifestations to vestibulo-auditory dysfunction. It has also a systemic vascular association of vasculitis type. We report a case of a 64 years old woman who presented an atypical form with anterior uveitis.

Published
2004

35. Aquaporin expression in pterygium

Author

VIEL, A, primary, MOTULSKY, E, additional, PERRET, J, additional, GREGOIRE, F, additional, CASPERS, L, additional, DE SAINT AUBAIN, N, additional, DELPORTE, C, additional, and WILLERMAIN, F, additional

Published
2013
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37. Photodynamic therapy for subfoveal classic choroidal neovascularization related to punctate inner choroidopathy (PIC) or presumed ocular histoplasmosis-like syndrome (POHS-like)

Author

UCL - Cliniques universitaires Saint-Luc, UCL - MD/NOPS - Département de neurologie et de psychiatrie, Postelmans, L, Snyers, Bernadette, Pasteels, B, Coquelet, P., Caspers, L, Verougstraete, C., Leys, A., Wirix, M, Mauget-Faysse, M, Quaranta, M, Rolland, F, Smets, E., 7th International Symposium on Ocular Inflammation, UCL - Cliniques universitaires Saint-Luc, UCL - MD/NOPS - Département de neurologie et de psychiatrie, Postelmans, L, Snyers, Bernadette, Pasteels, B, Coquelet, P., Caspers, L, Verougstraete, C., Leys, A., Wirix, M, Mauget-Faysse, M, Quaranta, M, Rolland, F, Smets, E., and 7th International Symposium on Ocular Inflammation

Abstract

Purpose : To evaluate the safety and efficacy of photodynamic therapy with verteporfin (PDT) for subfoveal classic choroidal neovascularization (CNV) related to punctate inner choroidopathy (PIC) or presumed ocular histoplasmosis-like syndrome (POHS-like). Methods : Retrospective review of 16 eyes from 14 patients with subfoveal classic CNV associated with PIC or POHS-like and treated with PDT. Results : The mean visual acuity increased from 4.5/10 (range: 1/10-9/10) to 7/10 (range: 2/10-10/10) after a mean follow-up of 21 months (range: 8-32 months) and a mean number of 2 PDT (range: 1-6). Visual acuity remained stable or improved in 13 of the 16 eyes (81%) and decreased in three. Conclusion : This nearly two-year follow-up study suggests that PDT could be helpful for patients with subfoveal classic CNV related to PIC or POHS-like.

Published
2005

46. Uvéites post-streptococciques

Author

Viel, A., primary, Kolyvras, N., additional, Catherine, J., additional, Relvas, L., additional, Judice, M., additional, Caspers, L., additional, and Willermain, F., additional

Published
2011
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