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3. Limits of Detection of Topically Applied Products in the Skin Using In Vivo Raman Spectroscopy.

Author

Nico, Cláudio, Bakker Schut, Tom C., Caspers, Peter J., and Puppels, Gerwin J.

Subjects
DETECTION limit, RAMAN spectroscopy, AMERICAN cooking, SKIN, PHARMACOKINETICS
Abstract

We have developed a method to determine the limit of detection (LoD) for quantitative measurement of exogenous analytes in the outer layer of the human skin by in vivo confocal Raman spectroscopy. The method is in accordance with the guidelines of the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use that have been adopted by regulatory authorities such as the American Food and Drug Administration and the European Medicines Agency. The method can be applied in silico so that the limit of detection can be assessed before starting a skin penetration study, for example, in areas of pharmaceutical formulation, pharmacokinetics, or toxicokinetics. This can significantly reduce the need for expensive and time-consuming feasibility studies. This paper describes the method to calculate this LoD as well as the experimental and methodological factors that can influence the calculation of the LoD. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Supplementary Information from A Novel Spectroscopically Determined Pharmacodynamic Biomarker for Skin Toxicity in Cancer Patients Treated with Targeted Agents

Author

Azan, Antoine, primary, Caspers, Peter J., primary, Bakker Schut, Tom C., primary, Roy, Séverine, primary, Boutros, Céline, primary, Mateus, Christine, primary, Routier, Emilie, primary, Besse, Benjamin, primary, Planchard, David, primary, Seck, Atmane, primary, Kamsu Kom, Nyam, primary, Tomasic, Gorana, primary, Koljenović, Senada, primary, Noordhoek Hegt, Vincent, primary, Texier, Matthieu, primary, Lanoy, Emilie, primary, Eggermont, Alexander M.M., primary, Paci, Angelo, primary, Robert, Caroline, primary, Puppels, Gerwin J., primary, and Mir, Lluis M., primary

Published
2023
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7. Supplementary Table S2 from A Novel Spectroscopically Determined Pharmacodynamic Biomarker for Skin Toxicity in Cancer Patients Treated with Targeted Agents

Author

Azan, Antoine, primary, Caspers, Peter J., primary, Bakker Schut, Tom C., primary, Roy, Séverine, primary, Boutros, Céline, primary, Mateus, Christine, primary, Routier, Emilie, primary, Besse, Benjamin, primary, Planchard, David, primary, Seck, Atmane, primary, Kamsu Kom, Nyam, primary, Tomasic, Gorana, primary, Koljenović, Senada, primary, Noordhoek Hegt, Vincent, primary, Texier, Matthieu, primary, Lanoy, Emilie, primary, Eggermont, Alexander M.M., primary, Paci, Angelo, primary, Robert, Caroline, primary, Puppels, Gerwin J., primary, and Mir, Lluis M., primary

Published
2023
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8. Data from A Novel Spectroscopically Determined Pharmacodynamic Biomarker for Skin Toxicity in Cancer Patients Treated with Targeted Agents

Author

Azan, Antoine, primary, Caspers, Peter J., primary, Bakker Schut, Tom C., primary, Roy, Séverine, primary, Boutros, Céline, primary, Mateus, Christine, primary, Routier, Emilie, primary, Besse, Benjamin, primary, Planchard, David, primary, Seck, Atmane, primary, Kamsu Kom, Nyam, primary, Tomasic, Gorana, primary, Koljenović, Senada, primary, Noordhoek Hegt, Vincent, primary, Texier, Matthieu, primary, Lanoy, Emilie, primary, Eggermont, Alexander M.M., primary, Paci, Angelo, primary, Robert, Caroline, primary, Puppels, Gerwin J., primary, and Mir, Lluis M., primary

Published
2023
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9. Supplementary Figure S1 from A Novel Spectroscopically Determined Pharmacodynamic Biomarker for Skin Toxicity in Cancer Patients Treated with Targeted Agents

Author

Azan, Antoine, primary, Caspers, Peter J., primary, Bakker Schut, Tom C., primary, Roy, Séverine, primary, Boutros, Céline, primary, Mateus, Christine, primary, Routier, Emilie, primary, Besse, Benjamin, primary, Planchard, David, primary, Seck, Atmane, primary, Kamsu Kom, Nyam, primary, Tomasic, Gorana, primary, Koljenović, Senada, primary, Noordhoek Hegt, Vincent, primary, Texier, Matthieu, primary, Lanoy, Emilie, primary, Eggermont, Alexander M.M., primary, Paci, Angelo, primary, Robert, Caroline, primary, Puppels, Gerwin J., primary, and Mir, Lluis M., primary

Published
2023
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11. Development of a near-infrared Raman spectroscopy setup compatible with fluorescence-guided surgery.

Author

Abbasi, Hamed, Lauwerends, Lorraine J., Bakker Schut, Tom C., Santos, Inês P., Caspers, Peter J., Hardillo, Jose A. U., Koljenović, Senada, Vahrmeijer, Alexander L., Baatenburg de Jong, Robert J., Keereweer, Stijn, and Puppels, Gerwin J.

Subjects
NEAR infrared spectroscopy, SPECTRAL imaging, TISSUE analysis, ONCOLOGIC surgery, RAMAN spectroscopy, FLUORESCENCE
Abstract

Near-infrared (NIR) fluorescence imaging using exogenous fluorescent agents provides whole-field images in real-time to assist the surgeon in the excision of a tumor. Although the method has high sensitivity, the specificity can sometimes be lower than expected. Raman spectroscopy can detect tumors with high specificity. Therefore, a combination of both techniques can be advantageous. A complication that must be addressed is that the NIR spectral region is favored by both techniques for (in vivo) tissue analysis. When fluorescence and Raman emissions spectrally overlap, it becomes challenging or impossible to detect the Raman signal. In this paper, by avoiding this overlap, we describe a Raman spectroscopy setup capable of recording high-quality Raman spectra from tissue containing NIR exogenous fluorescent agents. We identify an optimal wavelength interval (900–915 nm) for Raman excitation, which avoids both excitation of fluorescent dyes and Raman signal self-absorption by the tissue. In this way, Raman spectroscopy can be combined with the currently most-used NIR fluorescent dyes. This combined novel setup could pave the way for clinical trials benefiting from both fluorescence imaging and Raman spectroscopy to avoid positive margins in cancer surgery. [ABSTRACT FROM AUTHOR]

Published
2023
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14. Article in vitro–in vivo correlation in dermal delivery: The role of excipients

Author

Patel, Avnish, Iliopoulos, Fotis, Caspers, Peter J., Puppels, Gerwin J., Lane, Majella E., and Dermatology

Abstract

The composition of topical and transdermal formulations is known to determine the rate and the extent of drug delivery to and through the skin. However, to date, the role of excipients in these formulations on skin delivery of actives has received little attention from scientists in the field. Monitoring skin absorption of both drug and vehicle may provide insights into the mechanism by which excipients promote permeation and may facilitate the design of effective and safer products. Previously, we have investigated the use of quantitative Confocal Raman Spectroscopy (CRS) to investigate the delivery of an active to the skin, and we also reported the first fully quantitative study that compared this method with the well-established in vitro permeation test (IVPT) model. To further explore the potential of quantitative CRS in assessing topical delivery, the present work investigated the effects of commonly used excipients on the percutaneous absorption of a model drug, ibuprofen (IBU). Permeation of IBU and selected solvents following finite dose applications to human skin was determined in vitro and in vivo by Franz diffusion studies and quantitative CRS, respectively. The solvents used were propylene glycol (PG), dipropylene glycol (DPG), tripropylene glycol (TPG), and polyethylene glycol 300 (PEG 300). Overall, the cumulative amounts of IBU that permeated at 24 h in vitro were similar for PG, DPG, and TPG (p > 0.05). These three vehicles outperformed PEG 300 (p > 0.05) in terms of drug delivery. Concerning the vehicles, the rank order for in vitro skin permeation was DPG ≥ PG > TPG, while PEG 300 did not permeate the skin. A linear relationship between maximum vehicle and IBU flux in vitro was found, with a correlation coefficient (R2 ) of 0.95. When comparing in vitro with in vivo data, a positive in vitro–in vivo (IVIV) correlation between the cumulative permeation of IBU in vitro and the total amount of IBU that penetrated the stratum corneum (SC) in vivo was observed, with a Pearson correlation coefficient (R2 ) of 0.90. A strong IVIV correlation, R2 = 0.82, was found following the linear regression of the cumulative number of solvents permeated in vitro and the corresponding skin uptake in vivo measured with CRS. This is the first study to correlate in vivo permeation of solvents measured by CRS with data obtained by in vitro diffusion studies. The IVIV correlations suggest that CRS is a powerful tool for profiling drug and vehicle delivery from dermal formulations. Future studies will examine additional excipients with varying physicochemical properties. Ultimately, these findings are expected to lead to new approaches for the design, evaluation, and optimization of formulations that target actives to and through the skin.

Published
2021

17. Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way

Author

Aaboubout, Yassine, primary, Barroso, Elisa M., primary, Algoe, Mahesh, primary, Ewing-Graham, Patricia C., primary, ten Hove, Ivo, primary, Mast, Hetty, primary, Hardillo, José A., primary, Sewnaik, Aniel, primary, Monserez, Dominiek A., primary, Keereweer, Stijn, primary, Jonker, Brend P., primary, van Lanschot, Cornelia G. F., primary, Smits, Roeland W. H., primary, Nunes Soares, Maria R., primary, Ottevanger, Lars, primary, Matlung, Sanne E., primary, Seegers, Paul A., primary, van Dis, Vera, primary, Verdijk, Robert M., primary, Wolvius, Eppo B., primary, Caspers, Peter J., primary, Bakker Schut, Tom C., primary, Baatenburg de Jong, Robert J., primary, Puppels, Gerwin J., primary, and Koljenović, Senada, primary

Published
2021
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20. Is the Depth of Invasion a Marker for Elective Neck Dissection in Early Oral Squamous Cell Carcinoma?

Author

Aaboubout, Yassine, primary, van der Toom, Quincy M., additional, de Ridder, Maria A. J., additional, De Herdt, Maria J., additional, van der Steen, Berdine, additional, van Lanschot, Cornelia G. F., additional, Barroso, Elisa M., additional, Nunes Soares, Maria R., additional, ten Hove, Ivo, additional, Mast, Hetty, additional, Smits, Roeland W. H., additional, Sewnaik, Aniel, additional, Monserez, Dominiek A., additional, Keereweer, Stijn, additional, Caspers, Peter J., additional, Baatenburg de Jong, Robert J., additional, Bakker Schut, Tom C., additional, Puppels, Gerwin J., additional, Hardillo, José A., additional, and Koljenović, Senada, additional

Published
2021
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28. Natural moisturizing factor as a biomarker for filaggrin mutation status in a multi‐ethnic paediatric atopic dermatitis cohort.

Author

van Mierlo, Minke M. F., Caspers, Peter J., Jansen, Marieke S., Puppels, Gerwin J., Nouwen, Anouk E. M., Bronner, Madelon B., Pardo, Luba M., van Geel, Michel, and Pasmans, Suzanne G. M. A.

Subjects
*ATOPIC dermatitis, *FILAGGRIN, *BIOMARKERS, *PEDIATRICS, *CHILD patients, *PEDIATRIC dermatology
Abstract

Furthermore, the NMF content in patients with a single mutation in I FLG i was significantly different compared to both wild-type patients and patients with 2 mutations in I FLG i ( I p i < .01, Figure S2). The aim of our study was to screen the entire encoding region of I FLG i for potential mutations and to validate whether NMF could be used as a biomarker for I FLG i genotype in an unselected multi-ethnic clinical cohort of children with mild-to-severe disease. Raman spectroscopy is a rapid and non-invasive technique to measure natural moisturizing factor content in AD Natural moisturizing factor can predict I FLG i genotype with a sensitivity of 97% and specificity of 87% The thenar eminence's nonlesional skin is a suitable location to predict I FLG i genotype To the Editor, Atopic dermatitis (AD) is a common inflammatory skin disease among children with increasing prevalence in the past decades. [Extracted from the article]

Published
2021
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32. Natural moisturizing factor as a clinical marker in atopic dermatitis

Author

Nouwen, Anouk E. M., primary, Karadavut, Dilara, additional, Pasmans, Suzanne G. M. A., additional, Elbert, Niels J., additional, Bos, Lawrence D. N., additional, Nijsten, Tamar E. C., additional, Arends, Nicolette J. T., additional, Pijnenburg, Mariëlle W. H., additional, Koljenović, Senada, additional, Puppels, Gerwin J., additional, and Caspers, Peter J., additional

Published
2019
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35. Raman spectroscopy for cancer detection and cancer surgery guidance: translation to the clinics

Author

Santos, Inês P., primary, Barroso, Elisa M., additional, Bakker Schut, Tom C., additional, Caspers, Peter J., additional, van Lanschot, Cornelia G. F., additional, Choi, Da-Hye, additional, van der Kamp, Martine F., additional, Smits, Roeland W. H., additional, van Doorn, Remco, additional, Verdijk, Rob M., additional, Noordhoek Hegt, Vincent, additional, von der Thüsen, Jan H., additional, van Deurzen, Carolien H. M., additional, Koppert, Linetta B., additional, van Leenders, Geert J. L. H., additional, Ewing-Graham, Patricia C., additional, van Doorn, Helena C., additional, Dirven, Clemens M. F., additional, Busstra, Martijn B., additional, Hardillo, Jose, additional, Sewnaik, Aniel, additional, ten Hove, Ivo, additional, Mast, Hetty, additional, Monserez, Dominiek A., additional, Meeuwis, Cees, additional, Nijsten, Tamar, additional, Wolvius, Eppo B., additional, Baatenburg de Jong, Robert J., additional, Puppels, Gerwin J., additional, and Koljenović, Senada, additional

Published
2017
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36. A Novel Spectroscopically Determined Pharmacodynamic Biomarker for Skin Toxicity in Cancer Patients Treated with Targeted Agents

Author

Azan, Antoine, primary, Caspers, Peter J., additional, Bakker Schut, Tom C., additional, Roy, Séverine, additional, Boutros, Céline, additional, Mateus, Christine, additional, Routier, Emilie, additional, Besse, Benjamin, additional, Planchard, David, additional, Seck, Atmane, additional, Kamsu Kom, Nyam, additional, Tomasic, Gorana, additional, Koljenović, Senada, additional, Noordhoek Hegt, Vincent, additional, Texier, Matthieu, additional, Lanoy, Emilie, additional, Eggermont, Alexander M.M., additional, Paci, Angelo, additional, Robert, Caroline, additional, Puppels, Gerwin J., additional, and Mir, Lluis M., additional

Published
2016
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37. Water Concentration Analysis by Raman Spectroscopy to Determine the Location of the Tumor Border in Oral Cancer Surgery

Author

Barroso, Elisa M., primary, Smits, Roeland W.H., additional, van Lanschot, Cornelia G.F., additional, Caspers, Peter J., additional, ten Hove, Ivo, additional, Mast, Hetty, additional, Sewnaik, Aniel, additional, Hardillo, José A., additional, Meeuwis, Cees A., additional, Verdijk, Rob, additional, Noordhoek Hegt, Vincent, additional, Baatenburg de Jong, Robert J., additional, Wolvius, Eppo B., additional, Bakker Schut, Tom C., additional, Koljenović, Senada, additional, and Puppels, Gerwin J., additional

Published
2016
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38. In vivo Raman spectroscopy discriminates between FLGloss-of-function carriers vs wild-type in day 1-4 neonates

Author

Ní Chaoimh, Carol, Nico, Claudio, Puppels, Gerwin J., Caspers, Peter J., Wong, X.F.Colin C., Common, John E., Irvine, Alan D., and Hourihane, Jonathan O’B.

Abstract

Carriers of loss-of-function mutations in the filaggrin gene (LoF FLG) have less natural moisturizing factor (NMF) in their stratum corneum (SC) and an increased risk of atopic dermatitis (AD). Natural moisturizing factor can be measured noninvasively by Raman spectroscopy. The use of Raman-derived NMF at birth to screen for FLG genotype could inform targeted AD prevention, but values in neonatal populations are largely unexplored.

Published
2020
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42. Natural moisturizing factor as a clinical marker in atopic dermatitis.

Author

Nouwen, Anouk E. M., Karadavut, Dilara, Pasmans, Suzanne G. M. A., Elbert, Niels J., Bos, Lawrence D. N., Nijsten, Tamar E. C., Arends, Nicolette J. T., Pijnenburg, Mariëlle W. H., Koljenović, Senada, Puppels, Gerwin J., and Caspers, Peter J.

Subjects
ATOPIC dermatitis, BIOMARKERS, ATOPY, AMINO acid derivatives, BRONCHIAL spasm
Abstract

Atopic dermatitis (AD) is a heterogeneous disease with various biological origins and clinical appearances. Having decreased NMF did not show an association with early-onset AD, allergic rhinitis, BHR, asthma and combined asthma, and/or BHR. The results show a strong association between AD disease severity based on prior therapy, and NMF value. This study supports the hypothesis that patients with a decreased NMF value might benefit from different treatment regimens than patients with normal NMF value. [Extracted from the article]

Published
2020
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47. Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients

Author

Janssens, Michelle, primary, van Smeden, Jeroen, additional, Gooris, Gert S., additional, Bras, Wim, additional, Portale, Guiseppe, additional, Caspers, Peter J., additional, Vreeken, Rob J., additional, Hankemeier, Thomas, additional, Kezic, Sanja, additional, Wolterbeek, Ron, additional, Lavrijsen, Adriana P., additional, and Bouwstra, Joke A., additional

Published
2012
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