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125 results on '"Caselli, R J"'

1. Predicting Future Cognitive Decline with Hyperbolic Stochastic Coding

Author

Zhang, J., Dong, Q., Shi, J., Li, Q., Stonnington, C. M., Gutman, B. A., Chen, K., Reiman, E. M., Caselli, R. J., Thompson, P. M., Ye, J., and Wang, Y.

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition
Abstract

Hyperbolic geometry has been successfully applied in modeling brain cortical and subcortical surfaces with general topological structures. However such approaches, similar to other surface based brain morphology analysis methods, usually generate high dimensional features. It limits their statistical power in cognitive decline prediction research, especially in datasets with limited subject numbers. To address the above limitation, we propose a novel framework termed as hyperbolic stochastic coding (HSC). Our preliminary experimental results show that our algorithm achieves superior results on various classification tasks. Our work may enrich surface based brain imaging research tools and potentially result in a diagnostic and prognostic indicator to be useful in individualized treatment strategies.

Published
2021

6. Depressive symptoms, vascular risk factors and mild cognitive impairment: The Italian longitudinal study on aging

Author

Panza, F., D'Introno, A., Colacicco, A. M., Capurso, C., Del Parigi, A., Caselli, R. J., Todarello, O., Pellicani, V., Santamato, A., Scapicchio, P., Maggi, S., Scafato, E., Gandin, C., Capurso, A., Solfrizzi, V., Sergi, G., and for the ILSA Working Group

Subjects
Aged, 80 and over, Male, Depressive Disorder, Depression, Epidemiology, Incidence, Mild cognitive impairment, Dementia, Vascular risk factors, dementia, Age Distribution, Aged, Cardiovascular Diseases, Cognition Disorders, Cohort Studies, Female, Humans, Italy, Longitudinal Studies, Risk Factors, Severity of Illness Index, Sex Distribution, Vascular risk factors, 80 and over
Abstract

We evaluated the impact of depressive symptoms on the rate of incident mild cognitive impairment (MCI) after a 3.5-year follow-up, and we assessed the interaction between depressive symptoms and vascular risk factors for incident MCI.A total of 2,963 individuals from a sample of 5,632 65- to 84-year-old subjects were cognitively and functionally evaluated at the 1st and 2nd surveys of the Italian Longitudinal Study on Aging, a prospective cohort study with a 3.5-year follow-up. MCI and dementia were classified using current clinical criteria. Depressive symptoms were measured with the Geriatric Depression Scale.Among the 2,963 participants, 139 prevalent MCI cases were diagnosed at the 1st survey. During the 3.5-year follow-up, 105 new events of MCI were diagnosed. We did not observe any significant association between depressive symptoms and incident MCI (RR = 1.25, 95% CI = 0.85-1.84, chi(2) = 1.30, p0.25). No sociodemographic variables or vascular risk factors modified the relationship between depressive symptoms and incident MCI.In our population, depressive symptoms were not associated with the rate of incident MCI. Our findings did not support a role of sociodemographic variables or vascular risk factors in the link between depressive symptoms and incident MCI.

Published
2008

7. Quantitation of heteroplasmy of mtDNA sequence variants identified in a population of AD patients and controls by array-based resequencing

Author

Coon, K D, Valla, J, Szelinger, S, Schneider, L E, Niedzielko, T L, Brown, K M, Pearson, J V, Halperin, R, Dunckley, T, Papassotiropoulos, A, Caselli, R J, Reiman, E M, Stephan, D A, University of Zurich, and Stephan, D A

Subjects
1307 Cell Biology, 1313 Molecular Medicine, 1312 Molecular Biology, 610 Medicine & health, 11359 Institute for Regenerative Medicine (IREM)
Published
2006
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8. Common Kibra alleles are associated with human memory performance

Author

Papassotiropoulos, A, Stephan, D A, Huentelman, M J, Hoerndli, F J, Craig, D W, Pearson, J V, Huynh, K D, Brunner, F, Corneveaux, J, Osborne, D, Wollmer, M A, Aerni, A, Coluccia, D, Hänggi, Jürgen, Mondadori, C R A, Buchmann, A, Reiman, E M, Caselli, R J, Henke, K, de Quervain, D J F, University of Zurich, and Papassotiropoulos, A

Subjects
1000 Multidisciplinary, 10093 Institute of Psychology, 10076 Center for Integrative Human Physiology, 570 Life sciences, biology, 610 Medicine & health, 11359 Institute for Regenerative Medicine (IREM), 150 Psychology
Published
2006
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13. Cerebrovascular risk factors and preclinical memory decline in healthy APOE 4 homozygotes

Author

Caselli, R. J., primary, Dueck, A. C., additional, Locke, D. E. C., additional, Sabbagh, M. N., additional, Ahern, G. L., additional, Rapcsak, S. Z., additional, Baxter, L. C., additional, Yaari, R., additional, Woodruff, B. K., additional, Hoffman-Snyder, C., additional, Rademakers, R., additional, Findley, S., additional, and Reiman, E. M., additional

Published
2011
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19. Progranulin mutations and amyotrophic lateral sclerosis or amyotrophic lateral sclerosis-frontotemporal dementia phenotypes

Author

Schymick, J C, primary, Yang, Y, additional, Andersen, P M, additional, Vonsattel, J P, additional, Greenway, M, additional, Momeni, P, additional, Elder, J, additional, Chio, A, additional, Restagno, G, additional, Robberecht, W, additional, Dahlberg, C, additional, Mukherjee, O, additional, Goate, A, additional, Graff-Radford, N, additional, Caselli, R J, additional, Hutton, M, additional, Gass, J, additional, Cannon, A, additional, Rademakers, R, additional, Singleton, A B, additional, Hardiman, O, additional, Rothstein, J, additional, Hardy, J, additional, and Traynor, B J, additional

Published
2006
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21. Vascular risk factors, incidence of MCI, and rates of progression to dementia

Author

Solfrizzi, V., primary, Panza, F., additional, Colacicco, A. M., additional, D’Introno, A., additional, Capurso, C., additional, Torres, F., additional, Grigoletto, F., additional, Maggi, S., additional, Del Parigi, A., additional, Reiman, E. M., additional, Caselli, R. J., additional, Scafato, E., additional, Farchi, G., additional, and Capurso, A., additional

Published
2004
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30. Slowly progressive aphasia

Author

Caselli, R. J., primary, Jack, C. R., additional, Petersen, R. C., additional, Wahner, H. W., additional, and Yanagihara, T., additional

Published
1993
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39. Hereditary form of parkinsonism--dementia.

Author

Muenter, Manfred D., Forno, Lysia S., Hornykiewicz, Oleh, Kish, Stephen J., Maraganore, Demetrius M., Caselli, Richard J., Okazaki, Haruo, Howard, Frank M., Snow, Barry J., Calne, Donald B., Muenter, M D, Forno, L S, Hornykiewicz, O, Kish, S J, Maraganore, D M, Caselli, R J, Okazaki, H, Howard, F M Jr, Snow, B J, and Calne, D B

Published
1998
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45. Whole genome association analysis shows that ACE is a risk factor for Alzheimer's disease and fails to replicate most candidates from Meta-analysis

Author

Webster, J., Reiman, E. M., Zismann, V. L., Joshipura, K. D., John Pearson, Hu-Lince, D., Huentelman, M. J., Craig, D. W., Coon, K. D., Beach, T., Rohrer, K. C., Zhao, A. S., Leung, D., Bryden, L., Marlowe, L., Kaleem, M., Mastroeni, D., Grover, A., Rogers, J., Heun, R., Jessen, F., Kölsch, H., Heward, C. B., Ravid, R., Hutton, M. L., Melquist, S., Petersen, R. C., Caselli, R. J., Papassotiropoulos, A., Stephan, D. A., Hardy, J., Myers, A., and Netherlands Institute for Neuroscience (NIN)

Subjects
Original Article
Abstract

For late onset Alzheimer's disease (LOAD), the only confirmed, genetic association is with the apolipoprotein E (APOE) locus on chromosome 19. Meta-analysis is often employed to sort the true associations from the false positives. LOAD research has the advantage of a continuously updated meta-analysis of candidate gene association studies in the web-based AlzGene database. The top 30 AlzGene loci on May 1(st), 2007 were investigated in our whole genome association data set consisting of 1411 LOAD cases and neuropathoiogicaiiy verified controls genotyped at 312,316 SNPs using the Affymetrix 500K Mapping Platform. Of the 30 "top AlzGenes", 32 SNPs in 24 genes had odds ratios (OR) whose 95% confidence intervals that did not include 1. Of these 32 SNPs, six were part of the Affymetrix 500K Mapping panel and another ten had proxies on the Affymetrix array that had80% power to detect an association with α=0.001. Two of these 16 SNPs showed significant association with LOAD in our sample series. One was rs4420638 at the APOE locus (uncorrected p-value=4.58E-37) and the other was rs4293, located in the angiotensin converting enzyme (ACE) locus (uncorrected p-value=0.014). Since this result was nominally significant, but did not survive multiple testing correction for 16 independent tests, this association at rs4293 was verified in a geographically distinct German cohort (p-value=0.03). We present the results of our ACE replication aiongwith a discussion of the statistical limitations of multiple test corrections in whole genome studies.

46. Slowly progressive aphasia [1]

Author

Leger, J. -M, Levasseur, M., jean-claude baron, Cohen, L., Signoret, J. -L, Brunet, P., Caselli, R. J., Jack Jr, C. R., Petersen, R. C., Wahner, H. W., and Yanagihara, T.

50. Clinicopathologic correlations in 172 cases of rapid eye movement sleep behavior disorder with or without a coexisting neurologic disorder.

Author

Boeve BF, Silber MH, Ferman TJ, Lin SC, Benarroch EE, Schmeichel AM, Ahlskog JE, Caselli RJ, Jacobson S, Sabbagh M, Adler C, Woodruff B, Beach TG, Iranzo A, Gelpi E, Santamaria J, Tolosa E, Singer C, Mash DC, Luca C, Arnulf I, Duyckaerts C, Schenck CH, Mahowald MW, Dauvilliers Y, Graff-Radford NR, Wszolek ZK, Parisi JE, Dugger B, Murray ME, and Dickson DW

Subjects
Adult, Age of Onset, Aged, Aged, 80 and over, Alzheimer Disease complications, Alzheimer Disease pathology, Brain pathology, Cognitive Dysfunction complications, Cognitive Dysfunction pathology, Female, Humans, Male, Middle Aged, Multiple System Atrophy complications, Multiple System Atrophy pathology, Narcolepsy complications, Narcolepsy pathology, Supranuclear Palsy, Progressive complications, Supranuclear Palsy, Progressive pathology, Young Adult, Lewy Body Disease complications, Lewy Body Disease pathology, Parkinson Disease complications, Parkinson Disease pathology, REM Sleep Behavior Disorder complications, REM Sleep Behavior Disorder pathology
Abstract

Objective: To determine the pathologic substrates in patients with rapid eye movement (REM) sleep behavior disorder (RBD) with or without a coexisting neurologic disorder., Methods: The clinical and neuropathologic findings were analyzed on all autopsied cases from one of the collaborating sites in North America and Europe, were evaluated from January 1990 to March 2012, and were diagnosed with polysomnogram (PSG)-proven or probable RBD with or without a coexisting neurologic disorder. The clinical and neuropathologic diagnoses were based on published criteria., Results: 172 cases were identified, of whom 143 (83%) were men. The mean±SD age of onset in years for the core features were as follows - RBD, 62±14 (range, 20-93), cognitive impairment (n=147); 69±10 (range, 22-90), parkinsonism (n=151); 68±9 (range, 20-92), and autonomic dysfunction (n=42); 62±12 (range, 23-81). Death age was 75±9 years (range, 24-96). Eighty-two (48%) had RBD confirmed by PSG, 64 (37%) had a classic history of recurrent dream enactment behavior, and 26 (15%) screened positive for RBD by questionnaire. RBD preceded the onset of cognitive impairment, parkinsonism, or autonomic dysfunction in 87 (51%) patients by 10±12 (range, 1-61) years. The primary clinical diagnoses among those with a coexisting neurologic disorder were dementia with Lewy bodies (n=97), Parkinson's disease with or without mild cognitive impairment or dementia (n=32), multiple system atrophy (MSA) (n=19), Alzheimer's disease (AD)(n=9) and other various disorders including secondary narcolepsy (n=2) and neurodegeneration with brain iron accumulation-type 1 (NBAI-1) (n=1). The neuropathologic diagnoses were Lewy body disease (LBD)(n=77, including 1 case with a duplication in the gene encoding α-synuclein), combined LBD and AD (n=59), MSA (n=19), AD (n=6), progressive supranulear palsy (PSP) (n=2), other mixed neurodegenerative pathologies (n=6), NBIA-1/LBD/tauopathy (n=1), and hypothalamic structural lesions (n=2). Among the neurodegenerative disorders associated with RBD (n=170), 160 (94%) were synucleinopathies. The RBD-synucleinopathy association was particularly high when RBD preceded the onset of other neurodegenerative syndrome features., Conclusions: In this large series of PSG-confirmed and probable RBD cases that underwent autopsy, the strong association of RBD with the synucleinopathies was further substantiated and a wider spectrum of disorders which can underlie RBD now are more apparent., (Copyright © 2012 Elsevier B.V. All rights reserved.)

Published
2013
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