618 results on '"Casellas J"'
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2. SNP+ to predict dropout rates in SNP arrays
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Sastre, N., Mercadé, A., and Casellas, J.
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- 2023
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3. Classification of light Yorkshire pigs at different production stages using ordinary least squares and machine learning methods
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Casellas, J., Salgado-López, P., Lorente, J., Diaz, I. Solar, Rathje, T., Gasa, J., and Solà-Oriol, D.
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- 2024
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4. Transmission ratio distortion regions in the context of genomic evaluation and their effects on reproductive traits in cattle
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Id-Lahoucine, S., Cánovas, A., Legarra, A., and Casellas, J.
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- 2023
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5. Classification of light Yorkshire pigs at different production stages using ordinary least squares and machine learning methods
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Casellas, J., primary, Salgado-López, P., additional, Lorente, J., additional, Solar Diaz, I., additional, Rathje, T., additional, Gasa, J., additional, and Solà-Oriol, D., additional
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- 2023
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6. Technical note: PaGELL v.1.5: A flexible parametric program for the Bayesian analysis of longevity data within the context of animal breeding
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Casellas, J. and Brito, L.C.
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- 2017
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7. Screening for epistatic selection signatures: A simulation study
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Id-Lahoucine, S., Molina, A., Cánovas, A., and Casellas, J.
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- 2019
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8. Genetic and environmental relationships of detailed milk fatty acids profile determined by gas chromatography in Brown Swiss cows
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Pegolo, S., Cecchinato, A., Casellas, J., Conte, G., Mele, M., Schiavon, S., and Bittante, G.
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- 2016
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9. 772. Bayesian analysis of paternal and maternal gametic effects in a reciprocal cross between two Iberian varieties
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Srihi, H., primary, Ibáñez-Escriche, N., additional, Casellas, J., additional, Noguera, J.L., additional, Hernández, P., additional, Martín de Hijas, M., additional, Vázquez-Gómez, M., additional, Negro, S., additional, Rosas, J.P., additional, and Varona, L., additional
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- 2022
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10. 183. Genetic variability in the individual inbreeding load: genomic prediction for artificial purging
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Varona, L., primary, López-Carbonell, D., additional, Srihi, H., additional, Ramírez, M., additional, Martínez, P., additional, Hermida, M., additional, Altarriba, J., additional, and Casellas, J., additional
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- 2022
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11. On individual‐specific prediction of hidden inbreeding depression load
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Casellas, J.
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- 2018
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12. Expression patterns and genetic variation of the ovine skeletal muscle transcriptome of sheep from five Spanish meat breeds
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Noce, A., Cardoso, T. F., Manunza, A., Martínez, A., Cánovas, A., Pons, A., Bermejo, L. A., Landi, V., Sànchez, A., Jordana, J., Delgado, J. V., Adán, S., Capote, J., Vidal, O., Pazzola, M., Vacca, G. M., Casellas, J., and Amills, M.
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- 2018
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13. A machine learning COVID-19 mass screening based on symptoms and a simple olfactory test
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Universitat Rovira i Virgili, Azeli Y; Fernández A; Capriles F; Rojewski W; Lopez-Madrid V; Sabaté-Lissner D; Serrano RM; Rey-Reñones C; Civit M; Casellas J; El Ouahabi-El Ouahabi A; Foglia-Fernández M; Sarrá S; Llobet E, Universitat Rovira i Virgili, and Azeli Y; Fernández A; Capriles F; Rojewski W; Lopez-Madrid V; Sabaté-Lissner D; Serrano RM; Rey-Reñones C; Civit M; Casellas J; El Ouahabi-El Ouahabi A; Foglia-Fernández M; Sarrá S; Llobet E
- Abstract
The early detection of symptoms and rapid testing are the basis of an efficient screening strategy to control COVID-19 transmission. The olfactory dysfunction is one of the most prevalent symptom and in many cases is the first symptom. This study aims to develop a machine learning COVID-19 predictive tool based on symptoms and a simple olfactory test, which consists of identifying the smell of an aromatized hydroalcoholic gel. A multi-centre population-based prospective study was carried out in the city of Reus (Catalonia, Spain). The study included consecutive patients undergoing a reverse transcriptase polymerase chain reaction test for presenting symptoms suggestive of COVID-19 or for being close contacts of a confirmed COVID-19 case. A total of 519 patients were included, 386 (74.4%) had at least one symptom and 133 (25.6%) were asymptomatic. A classification tree model including sex, age, relevant symptoms and the olfactory test results obtained a sensitivity of 0.97 (95% CI 0.91–0.99), a specificity of 0.39 (95% CI 0.34–0.44) and an AUC of 0.87 (95% CI 0.83–0.92). This shows that this machine learning predictive model is a promising mass screening for COVID-19.
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- 2022
14. Bayesian analysis of parent‐specific transmission ratio distortion in seven Spanish beef cattle breeds
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Casellas, J., CañasÁlvarez, J. J., GonzálezRodríguez, A., PuigOliveras, A., Fina, M., Piedrafita, J., Molina, A., Díaz, C., Baró, J. A., and Varona, L.
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- 2017
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15. A cross-specific multiplicative binomial recursive model for the analysis of perinatal mortality in a diallel cross among three varieties of Iberian pig
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Varona, L., Noguera, J.L., Casellas, J., de Hijas, M.M., Rosas, J.P., and Ibáñez-Escriche, N.
- Abstract
Perinatal piglet mortality is an important factor in pig production from economic and animal welfare perspectives; however, the statistical analysis of mortality is difficult because of its categorical nature. Recent studies have suggested that a binomial model for the survival of each specific piglet with a logit approach is appropriate and that recursive relationships between traits are useful for taking into account non-genetic relationships with other traits. In this study, the recursive binomial model is expanded in two directions: (1) the recursive phenotypic dependence among traits is allowed to vary among groups of individuals or crosses, and (2) the binomial distribution is replaced by the multiplicative binomial distribution to account for over or underdispersion. In this study, five recursive multiplicative binomial models were used to obtain estimates of the Dickerson crossbreeding parameters in a diallel cross among three varieties of Iberian pigs [Entrepelado (EE), Torbiscal (TT), and Retinto (RR)]. Records (10, 255) from 2110 sows were distributed as follows: EE (433 records, 100 sows), ER (2336, 527), ET (942, 177), RE (806, 196), RR (870, 175), RT (2450, 488), TE (193, 36), TR (1993, 359), and TT (232, 68). Average litter size [Total Number Born (TNB)] and number of stillborns (SB) were 8.46 ± 2.27 and 0.25 ± 0.72, respectively. The overdispersion was evident with all models. The model with the best fit included a linear recursive relationship between TNB and the logit of ¿ of the multiplicative binomial distribution, and it implies that piglet mortality increases with litter size. Estimates of direct effects showed small differences among populations. The analysis of maternal effects indicated that the dams whose mothers were EE had a larger SB, while dams with RR mothers reduced the probability of born dead. The posterior estimates of heterosis suggested a reduction in SB when the sow is crosbred. The multiplicative binomial distribution provides a useful alternative to the binomial distribution when there is overdispersion in the data. Recursive models can be used for modeling non-genetic relationships between traits, even if the phenotypic dependency between traits varies among environments or groups of individuals. Piglet perinatal mortality increased with TNB and is reduced by maternal heterosis.
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- 2021
16. Transpancreatic precut papillotomy versus double-guidewire technique in difficult biliary cannulation: a systematic review and meta-analysis
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Guzman-Calderon E, Martinez-Moreno B, Casellas J, and Aparicio J
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Background and study aims Approximately 11% of biliary cannulations are considered difficult. The double guidewire (DGW-T) and transpancreatic sphincterotomy (TPS) are two useful techniques when difficult cannulation exists and the main pancreatic duct is unintentionally accessed. We carried out a systematic review and meta-analysis to evaluate the effectiveness and security of both DGW-T and TPS techniques in difficult biliary cannulation. Methods We conducted a systematic review in different databases, such as PubMed, OVID, Medline, and Cochrane Databases. Were included all RCT which showed a comparison between TPS and DGW in difficult biliary cannulation. Endpoints computed were successful cannulation rate, median cannulation time, and adverse events rate. Results Four studies were selected (4 RCTs). These studies included 260 patients. The mean age was 64.79 +/- 12.99 years. Of the patients, 53.6% were men and 46.4% were women. The rate of successful cannulation was 93.3% in the TPS group and 79.4% in the DGW-T group (P = 0.420). The rate of post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) was lower in patients who had undergone TPS than DGW-T (TPS: 8.9% vs DGW-T: 22.2%, P = 0.02). The mean cannulation time was 14.7 +/- 9.4 min in the TPS group and 15.1 +/- 7.4 min with DGW-T (P = 0.349). Conclusions TPS and DGW are two useful techniques in patients with difficult cannulation. They both have a high rate of successful cannulation; however, the PEP was higher with DGW-T than with TPS.
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- 2021
17. Per-oral pancreatoscopy-guided lithotripsy for the endoscopic management of pancreatolithiasis: A systematic review and meta-analysis
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Guzman-Calderon E, Martinez-Moreno B, Casellas J, and Aparicio J
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body regions ,pancreatolithiasis ,genetic structures ,lithotripsy ,per-oral pancreatoscopy - Abstract
Objective Pancreatic stones result from chronic pancreatitis and can occur in the main pancreatic duct, pancreatic branches or parenchyma. Although extracorporeal shock wave lithotripsy (ESWL) is considered the first-line treatment, per-oral pancreatoscopy (POP) has emerged as a useful method for treating pancreatic stones. The aim of this systematic review and meta-analysis was to determine the efficacy and safety of POP-guided lithotripsy, electrohydraulic lithotripsy (EHL) and laser lithotripsy (LL), in patients with pancreatolithiasis. Methods Literature review was conducted in PubMed, OVID, MEDLINE and Cochrane Library databases for studies published up to August 2020. Results Altogether 15 studies were analyzed, of which 11 were retrospective and four were prospective. The studies comprised 370 patients, of whom 66.4% were male. The patients underwent 218 EHL and 155 LL. The pooled technical and clinical success rate of the overall POP was 88.1% and 87.1%. For EHL-POP, the pooled technical success rate was 90.9% (95% CI 87.2%-95.2%) and the pooled clinical success rate was 89.8% (95% CI 87.2%-95.2%). While for LL-POP, the pooled technical and clinical success rate was 88.4% (95% CI 85.9%-95.1%) and 85.8% (95% CI 80.6%-91.6%). In total 43 adverse events occurred (12.1%; 95% CI 8.7%-15.5%). Conclusion POP-guided lithotripsy has a high rate of technical and clinical success for managing pancreatolithiasis with a low complication rate. Both EHL-POP and LL-POP achieve similar efficacy in the endoscopic therapy of pancreatolithiasis. Further large randomized controlled trials are needed to compare EHL-POP and LL-POP with ESWL and evaluate whether POP may replace ESWL as the first-line management of pancreatolithiasis.
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- 2021
18. Bayes factor analyses of heritability for serum and muscle lipid traits in Duroc pigs
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Casellas, J., Noguera, J.L., Reixach, J., Diaz, I., Amills, M., and Quintanilla, R.
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Heritability -- Research ,Bayes factors -- Usage ,Swine -- Genetic aspects ,Cholesterol metabolism -- Genetic aspects ,Fatty acid metabolism -- Genetic aspects ,Zoology and wildlife conservation - Abstract
Concern about pork quality has increased during last decades. Given the influence of fat content and composition on sensorial, nutritional, and technological variables of pork meat, an accurate knowledge about genetic control of pig lipid metabolism is required. This study focused on providing a broad characterization for serum and meat lipid trait heritability estimates in pigs. Analyses were performed on a population of 370 Duroc barrows and measured the additive polygenic background for the serum concentrations of cholesterol, triglyceride, and low- and high-density lipoproteins at 45 and 190 d of age (at slaughter), as well as intramuscular fat, cholesterol content, and C:12 to C:22 fatty acid content in longissimus thoracis et lumborum and gluteus medius muscles at slaughter. These traits were analyzed under Bayesian univariate animal linear models, and the statistical relevance of heritability estimates was evaluated through Bayes factor (BF); the model with polygenic additive effects was favored when BF >1. All serum lipid traits showed relevant genetic determinism, but the BF reached greater values at 190 d of age. Serum lipid traits displayed moderate modal estimates for heritability that ranged from 0.18 to 0.30. On the other hand, the genetic determinism for meat quality traits showed a heterogeneous behavior with large and less-than-1 BF. In general, longissimus thoracis et lumborum and gluteus medius muscles showed a similar pattern, with strong evidence of polygenic additive effects for intramuscular fat and palmitic, stearic, and cis-vaccenic fatty acids content, whereas oleic and muscle cholesterol content showed moderate to weak BF with moderate heritabilities. Similarly, results regarding linoleic, arachidonic, n-3, and n-6 fatty acids suggested a moderate genetic determinism, but only in gluteus medius muscle. For the remaining traits (myristic and palmitoleic fatty acids in both muscles, along with linoleic, arachidonic, n-3, and n-6 fatty acids in the longissimus thoracis et lumborum muscle), no statistical evidence for genetic control was observed in this study. As a whole, these results confirm the complexity of lipid metabolism in pigs. Key words: Bayes factor, cholesterol, fatty acid, heritability, lipoprotein, meat quality doi: 10.2527/jas.2009-2205
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- 2010
19. Accounting for additive genetic mutations on litter size in Ripollesa sheep
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Casellas, J., Caja, G., and Piedrafita, J.
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Gene mutations -- Research ,Sheep -- Growth ,Sheep -- Genetic aspects ,Company growth ,Zoology and wildlife conservation - Abstract
Little is known about mutational variability in livestock, among which only a few mutations with relatively large effects have been reported. In this manuscript, mutational variability was analyzed in 1,765 litter size records from 404 Ripollesa ewes to characterize the magnitude of this genetic source of variation and check the suitability of including mutational effects in genetic evaluations of this breed. Threshold animal models accounting for additive genetic mutations were preferred to models without mutational contributions, with an average difference in the deviance information criterion of more than 5 units. Moreover, the statistical relevance of the additive genetic mutation term was checked through a Bayes factor approach, which showed that the models with mutational variability were 8.5 to 22.7 times more probable than the others. The mutational heritability (percentage of the phenotypic variance accounted for by mutational variance) was 0.6 or 0.9%, depending on whether genetic dominance effects were accounted for by the analytical model. The inclusion of mutational effects in the genetic model for evaluating litter size in Ripollesa ewes called for some minor modifications in the genetic merit order of the individuals evaluated, which suggested that the continuous uploading of new additive mutations could be taken into account to optimize the selection scheme. This study is the first attempt to estimate mutational variances in a livestock species and thereby contribute to better characterization of the genetic background of productive traits of interest. Key words: animal breeding, genetic variability, litter size, mutation, Ripollesa breed doi: 10.2527/jas.2009-2117
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- 2010
20. Application of the microarray technology to the transcriptional analysis of muscle phenotypes in pigs
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Pena, R. N., Quintanilla, R., Manunza, A., Gallardo, D., Casellas, J., and Amills, M.
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- 2014
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21. Genetic background and phenotypic characterization over two farrowings of leg conformation defects in Landrace and Large White sows
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de Sevilla, X. Fernandez, Fabrega, E., Tibau, J., and Casellas, J.
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Sows -- Physiological aspects ,Sows -- Genetic aspects ,Animal development -- Genetic aspects ,Zoology and wildlife conservation - Abstract
A Bayesian threshold animal model was applied to evaluate the prevalence over 2 farrowings and genetic background of overall leg conformation score and the presence or absence of 6 specific leg defects (abnormal hoof growth, splay footed, plantigradism, straight pasterns, sickle-hocked legs, and the presence of swelling or injuries) in purebred Landrace and Large White sows. Data sets contained phenotypic records from 2,477 and 1,550 Landrace and Large White females, respectively, at the end of the growing period. Leg conformation data from first and second farrowings were available for 223 and 191 Landrace sows and 213 and 193 Large White sows, respectively. Overall leg conformation deteriorated with age, with statistically relevant differences between females at the end of the growing period, first farrowing (FF), and second farrowing (SF). In a similar way, the prevalence of the 6 specific leg defects increased between the end of the growing period and FF (with the exception of straight pasterns in the Landrace population). Differences between FF and second farrowing were statistically relevant for hoof growth (highest posterior density regions at 95% did not overlap), plantigradism, sickle-hocked legs, and overall leg conformation score in Landrace and for sickle-hocked leg and overall leg conformation score in Large White. The statistical relevance of the genetic background was tested through the Bayes factor (BF) between the model with the additive genetic component and the model with 0 heritability (nonheritable). Heritability ([h.sup.2]) was discarded (BF < 1) for sickle-hocked leg in both breeds, whereas decisive evidence (BF > 100) of genetic background was obtained for overall leg conformation score in Landrace and Large White sows ([h.sup.2] = 0.27 and 0.38, respectively), hoof growth in both breeds ([h.sup.2] = 0.22 and 0.26, respectively), and plantigradism ([h.sup.2] = 0.34) and the presence of swelling or injuries in Landrace ([h.sup.2] = 0.27). Note that a BF > 100 implies that the model with infinitesimal genetic effects was more than 100 times more suitable than the model without genetic effects, a conclusive estimate within the Bayesian framework. The remaining traits (splay footed and straight pasterns) registered BF values ranging from 11.6 to 35.1 and [h.sup.2] values ranging from 0.09 to 0.19. These results indicated a moderate genetic determinism for leg conformation in Landrace and Large White sows. Key words: heritability, Landrace, Large White, leg conformation
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- 2009
22. Bayesian threshold analysis of direct and maternal genetic parameters for piglet mortality at farrowing in Large White, Landrace, Pietrain populations
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Ibanez-Escriche, N., Varona, L., Casellas, J., Quintanilla, R., and Noguera, J.L.
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Bayesian statistical decision theory -- Usage ,Mortality -- United States ,Mortality -- Research ,Swine -- Genetic aspects ,Swine -- Growth ,Company growth ,Zoology and wildlife conservation - Abstract
A Bayesian threshold model was fitted to analyze the genetic parameters for farrowing mortality at the piglet level in Large White, Landrace, and Pietrain populations. Field data were collected between 1999 and 2006. They were provided by 3 pig selection nucleus farms of a commercial breeding company registered in the Spanish Pig Data Bank (BDporc). Analyses were performed on 3 data sets of Large White (60,535 piglets born from 4,551 litters), Landrace (57,987 piglets from 5,008 litters), and Pietrain (42,707 piglets from 4,328 litters) populations. In the analysis, farrowing mortality was considered as a binary trait at the piglet level and scored as 1 (alive piglet) or 0 (dead piglet) at farrowing or within the first 12 h of life. Each breed was analyzed separately, and operational models included systematic effects (year-season, sex, litter size, and order of parity), direct and maternal additive genetic effects, and common litter effects. Analyses were performed by Bayesian methods using Gibbs sampling. The posterior means of direct heritability were 0.02, 0.06, and 0.10, and the posterior means of maternal heritability were 0.05, 0.13, and 0.06 for Large White, Landrace, and Pietrain populations, respectively. The posterior means of genetic correlation between the direct and maternal genetic effects for Landrace and Pietrain populations were -0.56 and -0.53, and the highest posterior intervals at 95% did not include zero. In contrast, the posterior mean of the genetic correlation between direct and maternal effects was 0.15 in the Large White population, with the null correlation included in the highest posterior interval at 95%. These results suggest that the genetic model of evaluation for the Landrace and Pietrain populations should include direct and maternal genetic effects, whereas farrowing mortality could be considered as a sow trait in the Large White population. Key words: Bayesian analysis, farrowing mortality, genetic parameter, piglet mortality, threshold model, variance component
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- 2009
23. Analysis of founder-specific inbreeding depression on birth weight in Ripollesa lambs
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Casellas, J., Piedrafita, J., Caja, G., and Varona, L.
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Lambs -- Growth ,Lambs -- Diseases ,Birth size -- Measurement ,Birth weight -- Measurement ,Inbreeding -- Research ,Company growth ,Zoology and wildlife conservation - Abstract
Although inbreeding (F) is a topic of major concern in animal breeding, estimates of inbreeding depression are usually obtained by modeling the overall F coefficient of each individual, without considering that the recessive (deleterious) genetic load of a given population may be unevenly distributed among the founder genomes. The founder-specific partial F coefficient is calculated as the identity-by-descent probability at any given autosomal locus related to a particular founder and allows a more detailed analysis of inbreeding depression on productive traits. Within this context, birth BW data from 2,459 Ripollesa lambs were analyzed under a hierarchical animal model without F-related covariates (model 0), with inbreeding depression modeled by the overall F coefficient (model F1), or by the partial F coefficient of 9 founders that made a relevant contribution to the population inbreeding (model F2). A straightforward empirical Bayes factor (BF) was developed for testing statistical relevance of each F-related covariate, in which greater-than-1 values favored the model including the covariate. The deviance information criterion (DIC) clearly supported model F1 (5,767.8) rather than model 0 (5,771.2), suggesting that inbreeding depression had a relevant influence on birth BW data. The linear effect of inbreeding depression was statistically relevant in model F1 (BF = 2.52 x [10.sup.35]), with lamb birth BW declining by -13.6 g with each 1% F increase. The quadratic effect of inbreeding depression was almost null in model F1 (BF = 0.02), as suggested by the reduction in DIC (5,766.9) when this effect was removed from model F1. On the other hand, model F2 provided a similar DIC (5,767.9) value, with this parameter decreasing to 5,764.7 when nonrelevant founder-specific inbreeding depression effects were removed. Substantial heterogeneity in founder-specific inbreeding depression was reported by model F2, in which estimates for 4 of the 9 founders did not differ from zero (BF between 0.05 and 0.42), whereas 5 founders originated moderate (-8.2 g for each 1% F increase; BF = 1.42) to large inbreeding depression (-96.2 g for each 1% F increase; BF = 8.80 x [10.sup.19]). The substantial variability between founder estimates suggested that inbreeding depression effects may mainly be due to a few alleles with major deleterious effects. These results contribute valuable information that should help to achieve more accurate management of inbreeding in the Ripollesa breed. Key words: birth weight, empirical Bayes factor, founder, inbreeding depression, Ripollesa sheep
- Published
- 2009
24. Transcriptional analysis of intramuscular fatty acid composition in the longissimus thoracis muscle of Iberian × Landrace back-crossed pigs
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Pena, R. N., Noguera, J. L., Casellas, J., Díaz, I., Fernández, A. I., Folch, J. M., and Ibáñez-Escriche, N.
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- 2013
- Full Text
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25. Genetics of serum and muscle lipids in pigs
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Casellas, J., Vidal, O., Pena, R. N., Gallardo, D., Manunza, A., Quintanilla, R., and Amills, M.
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- 2013
- Full Text
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26. Effect of leg conformation on survivability of Duroc, Landrace, and Large White sows
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de Sevilla, X. Fernandez, Fabrega, E., Tibau, J., and Casellas, J.
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Sows -- Physiological aspects ,Sows -- Research ,Longevity -- Research ,Extremities, Lower -- Research ,Extremities, Lower -- Physiological aspects ,Leg -- Research ,Leg -- Physiological aspects ,Zoology and wildlife conservation - Abstract
Sow longevity influences farm economy and can be considered an important indicator of animal welfare. Body features such as leg conformation can play a key role in sow longevity, although little is known about its effect on culling decisions. Within this context, longevity data from 587 Duroc, 239 Landrace, and 217 Large White sows were analyzed with special emphasis on the effect of leg conformation. Sow longevity was analyzed twice for each breed, testing the effect of a subjective overall score for leg conformation, or the presence or absence of 6 specific leg conformation defects. Each preliminary model also included a teat conformation score with 3 levels, farm or origin, backfat thickness at 6 mo of age, and 2 continuous sources of variation, namely the age at the first farrowing and the number of piglets born alive at each farrowing. Overall leg conformation score influenced (P < 0.01) sow longevity in Duroc, Landrace, and Large White sows, with a greater hazard ratio (HR) for poorly conformed sows (1.56, 2.16, and 1.79, respectively) than for well-conformed sows (0.32, 0.66, and 0.68, respectively). Abnormal hoof growth reduced survivability in Duroc (HR = 2.78; P < 0.001) and Landrace sows (HR = 1.88; P < 0.01); the presence of splayed feet (P < 0.05) or bumps and injuries (P < 0.001) increased the risk of culling in Duroc sows (HR = 2.08 and 3.57, respectively), whereas the incidence of straight pastern increased the HR in Large White sows (HR = 2.49; P < 0.01). In all 3 breeds, longevity decreased for plantigrade sows, with a greater HR in Duroc (HR = 3.38; P < 0.001) than in Landrace (HR = 1.53; P < 0.10) and Large White sows (HR = 1.73; P < 0.05). Teat conformation did not influence sow longevity (P > 0.10). Estimates of heritability for longevity in Duroc sows ranged from 0.05 to 0.07 depending on the algorithm applied. Leg conformation had a substantial effect on sow longevity, where an accurate removal of poorly leg-conformed candidate gilts before first mating could improve sow survival and reduce culling costs. These moderate estimates of heritability indicated that survivability of Duroc sows could be genetically improved by direct selection for leg conformation. Key words: leg conformation, longevity, sow, survival analysis
- Published
- 2008
27. Endoscopic ultrasound-guided, through-the-needle forceps biopsy for diagnosis of pancreatic cystic lesions: a systematic review
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Guzman-Calderon, E, Martinez B, Casellas, J, de Madaria, E, and Aparicio, J
- Abstract
Background and study aims Pancreatic cystic lesions (PCL), are a heterogeneous group of cystic lesions. Some patients with PCLs have a significantly higher overall risk of pancreatic cancer and the only test that can differentiate benign and malignnat PCL is fine-needle aspiration plus cytological analysis, but its sensitivity is very low. Through-the-needle direct intracystic biopsy is a technique that allows acquisition of targeted tissue from PCLs and it may improve the diagnostic yield for them. The aim of this study was to review articles about endoscopic ultrasound (EUS)-guided through-the-needle intracystic biopsy for targeted tissue acquisition and diagnosis of PCLs. Methods A systematic review of computerized bibliographic databases was carried out for studies of EUS-guided through-the-needle forceps biopsy (EUS-TTNB) of PCLs. The percentages and their 95 % confidence intervals (CIs) were calculated for all the considered endpoints (technical success, adequate specimens, adverse events (AEs), and overall diagnosis). Results Overall, eight studies with a total of 423 patients were identified. Pooled technical success was 95.6 % of the cases (399/423), (95 % CI, 93.2 %-97.3 %). Technical failure rate was 5.1 % (24 cases). Frequency of adequate specimens was 82.2 %, (95 % CI, 78.5 %-85.8 %). Adverse events were reported in seven of the eight studies. Forty-two total adverse events were reported (10.1 %) (95 % CI, 7.3 %-13.6 %). The overall ability to provide a specific diagnosis with EUS-TTNB for diagnosis of pancreatic cystic lesions was 74.6 % (313 cases), (95 % CI: 70.2 %-78.7 %). The most frequent diagnoses found with EUS-TTNB were mucinous cystic neoplasms (MCN) in 96 cases (30.6 %), IPMN in 80 cases (25.5 %), and serous cystoadenoma neoplasm (SCN) in 48 cases (15.3 %). Conclusions Through-the-needle forceps biopsy appears to be effective and safe, with few AE for diagnosis of pancreatic cystic lesions. This technique had acceptable rates of technical and clinical success and an excellent safety profile. TTNB is associated with a high tissue acquisition yield and provided additional diagnostic yield for mucinous pancreatic lesions. TTNB may be a useful adjunctive tool for EUS-guided assessment of PCLs.
- Published
- 2020
28. Survival quantitative trait locus fine mapping by measuring and testing for Hardy--Weinberg and linkage disequilibrium
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Casellas, J.
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Hardy-Weinberg formula -- Analysis ,Life (Biology) -- Research ,Life (Biology) -- Statistics ,Life (Biology) -- Analysis ,Population genetics -- Analysis ,Population genetics -- Statistics ,Survival and emergency rations -- Statistics ,Survival and emergency rations -- Analysis ,Biological sciences - Abstract
I show that fine-scale localization of a survival-related locus call be accomplished on the basis of deviations from Hardy-Weinberg equilibrium and linkage disequilibrium at closely linked marker loci. The method is based on [X.sup.2]-tests and they can be performed for age-specific samples of alive (or dead) individuals, as for combined samples of alive and dead individuals.
- Published
- 2007
29. Analysis of litter size and days to lambing in the Ripollesa ewe. II. Estimation of variance components and response to phenotypic selection on litter size
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Casellas, J., Caja, G., Ferret, A., and Piedrafita, J.
- Subjects
Bayesian statistical decision theory -- Usage ,Ewes -- Genetic aspects ,Ewes -- Research ,Genetic variation -- Research ,Zoology and wildlife conservation - Abstract
A performance data set from 376 Ripollesa purebred ewes of the experimental flock of the Universitat Autbnoma of Barcelona was analyzed using a bivariate Bayesian threshold-linear model. The data set contained 1,598 litter size records and 1,699 days-to-lambing records. The model included the additive genetic effect of each animal and 3 nongenetic sources of variation: ewe age, year of lambing, and the permanent environmental effect characterized by the ewe. The flock was phenotypically selected for litter size since 1986, and replacement ewes and rams were selected from the progeny of the more prolific ewes, which had at least 3 deliveries recorded. The phenotypic trend for litter size was positive, whereas days to lambing followed an unclear pattern. Both traits had low heritabilities; 0.13 for litter size and 0.11 for days to lambing. Response to selection was evaluated through (a) the average breeding value of the ewe lambs chosen annually, and (b) the average breeding value of the overall flock. The first measurement suggested a positive trend for litter size, although it showed important oscillations. On the other hand, the average breeding value for the overall flock showed a stable positive tendency after yr 4 of selection, with estimates clearly different from zero after yr 11 of selection. A significant increase in the incidence of multiple births was observed, with a mode of approximately 10%. The correlated response in days to lambing did not show a significant trend. The effect of year of lambing also positively influenced both litter size and days to lambing, although important oscillations were observed between years. Results indicated that litter size in sheep can be effectively improved through phenotypic selection, even in small flocks; moreover, days to lambing could also be genetically improved, given the estimate obtained for its heritability. Key words: Bayesian inference, days to lambing, genetic trend, litter size, Ripollesa sheep, threshold models
- Published
- 2007
30. Analysis of litter size and days to lambing in the Ripollesa ewe. I. Comparison of models with linear and threshold approaches
- Author
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Casellas, J., Caja, G., Ferret, A., and Piedrafita, J.
- Subjects
Ewes -- Genetic aspects ,Ewes -- Research ,Zoology and wildlife conservation - Abstract
The analysis focused on model fitting of 2 ewe reproductive traits, litter size, and days to lambing (interval between the introduction of the ram into the flock and the subsequent parturition of the ewes). The experimental data set of the Universitat Autonoma of Barcelona flock was used, including 1,598 records of litter size and 1,699 records of days to lambing from 376 Ripollesa ewes between 1986 and 2005. Univariate and bivariate models were considered as beginning points with linear or threshold approximation for litter size. Model fitting was evaluated in terms of goodness-of-fit and predictive ability, using the mean square error and the correlation between phenotypic and predicted records ([[rho].sub.y,x]) as reference parameters. The bivariate model was preferable for both variables, minimizing mean square error and maximizing [[rho].sub.y,x]. A threshold approximation for litter size was preferable over a linear approximation. Models were also compared with a simulation study, comparing the correlation coefficient between simulated and predicted breeding values ([[rho].sub.a,[??]). The bivariate threshold model was favored, with a [[rho].sub.y,[??]] of 0.677 and 0.834 for litter size and days to lambing, respectively. Correlation coefficients between simulated and predicted breeding values in the bivariate linear model were reduced slightly to 0.651 and 0.831, respectively, and they were lowest with linear univariate models (0.642 and 0.802). Although the bivariate models for ewe litter size and days to lambing were more accurate than the univariate models, the threshold approaches showed a greater advantage under the bivariate model. For the purpose of genetic evaluation of litter size in sheep, use of the threshold-linear model seems justified. In the Ripollesa breed, the evaluation of litter size can benefit from recording birth weight. Key words: days to lambing, goodness-of-fit, litter size, predictive ability, Ripollesa breed
- Published
- 2007
31. Association analyses between the prion protein locus and reproductive and lamb weight traits in Ripollesa sheep
- Author
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Casellas, J., Caja, G., Bach, R., Francino, O., and Piedrafita, J.
- Subjects
Prions -- Research ,Sheep breeds -- Genetic aspects ,Sheep breeds -- Research ,Sheep breeds -- Physiological aspects ,Birth size -- Research ,Birth weight -- Research ,Haplotypes -- Research ,Zoology and wildlife conservation - Abstract
The objective of this study was to analyze the association between the haplotypes of the prion protein (PrP) locus and several reproductive and lamb weight traits in Ripollesa sheep. Prion protein genotypes were available for a total of 310 sheep (7 rams, 114 ewes, and 189 lambs), all of them belonging to the purebred Ripollesa flock of the Universitat Autbnoma of Barcelona, for which all sheep had a known pedigree. In addition, the genotype of 24 historical descendants of the previously genotyped adult individuals was reconstructed, provided that both parents were homozygous for PrP haplotypes. Only 3 haplotypes (ARR, ARQ, and ARH) were observed in the PrP locus of the sheep sampled. Reproductive traits included conception rate and litter size, whereas birth BW and 90-d BW were the lamb weight traits studied. The additive effect of PrP haplotypes was analyzed through Bayesian animal threshold and linear models, for reproduction and weight traits, respectively. Ewe reproductive data belonged to 89 ewes that gave 492 conception rate records and 440 litter size records. Analyses of BW at birth and at 90 d of age were made on 323 and 164 lamb records, respectively. No associations between PrP haplotypes and conception rate and BW traits were observed. For litter size, the effect of the ARH haplotype was greater than that of the ARQ haplotype. Differences between ARH and ARR haplotypes also suggested an advantage for the ARH. As a whole, our results indicated that the selection favorable to increase litter size in Ripollesa ewes may also increase the ARH haplotype frequency, which contradicts the recommendations of the current European Union legislation aiming to increase the genetic resistance to scrapie. As a consequence, scrapie genotyping needs to be included as a new selection criterion in the breed. Key words: birth weight, conception rate, litter size, prion protein, Ripollesa breed, sheep
- Published
- 2007
32. Survival analysis from birth to slaughter of Ripollesa lambs under semi-intensive management
- Author
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Casellas, J., Caja, G., Such, X., and Piedrafita, J.
- Subjects
Lambs -- Research ,Life spans (Biology) -- Research ,Livestock -- Breeding ,Livestock -- Research ,Zoology and wildlife conservation - Abstract
The survivability from birth to slaughter of 1,487 Ripollesa lambs with a preslaughter overall mortality of 9.6% was studied under the proportional hazards framework, assuming a Weibull distribution for the baseline hazards function. A sire frailty model was fitted, with the common environment received by the lamb as an additional random source of variation. Common environment was considered time-dependent and was characterized by the dam and the contemporary lamb group during the preweaning and fattening periods, respectively. Only 3 fixed effects were statistically significant: the linear and quadratic effects of birth weight (P [less than or equal to] 0.001), the relative position of the delivery within the lambing season (P [less than or equal to] 0.001), and the presence of stillbirths or mummified fetuses within the litter (P [less than or equal to] 0.05). Birth type and parity of the ewe were significant only when birth weight was removed from the model (P [less than or equal to] 0.001 and P [less than or equal to] 0.05, respectively). Nevertheless, the model including birth weight became preferable according to the Akaike's information criterion. Survivability dramatically decreased with extreme birth weights, although it reached a survival probability greater than 93.5% within the 3.3 to 5.4 kg range, indicating an optimum birth weight range of Ripollesa lambs for survival purposes. The hazard ratio (HR) increased for births occurring within the last third of the lambing period (HR = 1.70; P [less than or equal to] 0.05), as well as for primiparous ewes that lambed in December and January (HR = 5.36; P [less than or equal to] 0.001). Survival probability decreased for lambs born from litters with 1 or more stillbirths or mummified fetuses (HR = 1.61; P [less than or equal to] 0.05). The variance component estimated for sire variance (0.07) was clearly lower than that of the common environment (1.87), with a heritability estimate of 0.027. Key words: lamb survival, proportional hazard, Ripollesa breed, survival analysis
- Published
- 2007
33. Genetic inbreeding depression load for morphological traits and defects in the Pura Raza Española horse
- Author
-
Universidad de Sevilla. Departamento de Agronomía, Poyato Bonilla, Julia, Perdomo-González, Davinia I., Sánchez Guerrero, María José, Varona, L., Molina, Antonio, Casellas, J., Valera Córdoba, Mercedes, Universidad de Sevilla. Departamento de Agronomía, Poyato Bonilla, Julia, Perdomo-González, Davinia I., Sánchez Guerrero, María José, Varona, L., Molina, Antonio, Casellas, J., and Valera Córdoba, Mercedes
- Abstract
Background: Inbreeding is caused by mating between related individuals and is associated with reduced ftness and performance (inbreeding depression). Several studies have detected heterogeneity in inbreeding depression among founder individuals. Recently, a procedure was developed to predict hidden inbreeding depression load that is associ‑ ated with founders using the Mendelian sampling of non-founders. The objectives of this study were to: (1) analyse the population structure and general inbreeding, and (2) test this recent approach for predicting hidden inbreeding depression load for four morphological traits and two morphology defects in the Pura Raza Española (PRE) horse breed. Results: The regression coefcients that were calculated between trait performances and inbreeding coefcients demonstrated the existence of inbreeding depression. In total, 58,772,533 partial inbreeding coefcients (Fij) were esti‑ mated for the whole PRE population (328,706 horses). We selected the descendants of horses with a Fij≥6.25% that contributed to at least four ofspring and for which morphological traits were measured for the subsequent analysis of inbreeding depression load (639 horses). A pedigree was generated with the last fve generations (5026 animals) used as the reference population (average inbreeding coefcient of 8.39% and average relatedness coefcient of 10.76%). Heritability estimates ranged from 0.08 (cresty neck) to 0.80 (height at withers), whereas inbreeding depression load ratios ranged from 0.01 (knock knee) to 0.40 (length of shoulder), for an inbreeding coefcient of 10%. Most of the correlations between additive and inbreeding depression load genetic values and correlations between inbreeding depression load genetic values for the diferent traits were positive or near 0. Conclusions: Although the average inbreeding depression loads presented negative values, a certain percentage of the animals showed neutral or even positive values. Thus, high levels of inbreed
- Published
- 2020
34. Retention of different sizes of electronic identification boluses in the forestomachs of sheep
- Author
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Ghirardi, J.J., Caja, G., Garin, D., Hernandez-Jover, M., Ribo, O., and Casellas, J.
- Subjects
Sheep -- Research ,Zoology and wildlife conservation - Abstract
Twelve types of electronic identification ruminal boluses of different dimensions were used to obtain a model for predicting their retention in the forestomachs of sheep. Boluses (n = 1,662) were made of ceramic materials, and their dimensions varied in o.d. (9 to 21 mm), length (37 to 68 mm), volume (2.5 to 21.0 mL), and specific gravity (0.85 to 3.91). Each bolus contained a half-duplex, standardized, glass-encapsulated transponder (32 x 3.8 mm). Boluses were administered to sheep (n = 1,497) of different ages by using the appropriate balling guns, and their retention under semiintensive conditions was recorded for at least 2 yr. When a bolus was lost, the sheep was rebolused with a heavier bolus. All sheep wore 2 plastic ear tags: one for the official control of health programs and the other for farm use. To determine the anatomical limit for a bolus passing through the gastrointestinal tract, the size of the reticulo-omasal orifice was measured in 46 adult sheep (male, n = 14; female, n = 32) that died by causes not related to bolus administration during the experiment. No signs of disease or growth alteration were detected in the bolused sheep. Total ear tag losses during the experiment period were 7.5% on average. Bolus retention (5 to 100%) varied according to bolus features and age of the sheep, but it showed a plateau after 18 mo. Inadequately dimensioned boluses were regurgitated or passed through the gastrointestinal tract and were excreted with the feces. The diameter of the reticulo-omasal orifice in adult sheep differed between male and female (23.1 and 21.8 mm, respectively; P < 0.01) and was greater than the o.d. of the retained boluses. Retention rate was predicted from bolus weight and volume by a logistic regression ([R.sup.2] = 0.997; P < 0.001). When retention data from the literature (59.0 to 100%) were included in the model, the adjustment was slightly lower ([R.sup.2] = 0.967). As a result, the minimum bolus weight estimated to reach a 99.5% retention rate in sheep varied between 16 and 45 g when volume varied between 3 and 22 mL, for boluses with a specific gravity between 2.0 and 5.2. In conclusion, bolus retention rate in sheep varied dramatically according to their features. For safe and efficient retention of electronic identification boluses in sheep, boluses of small volume and diameter (e.g., Key words: electronic identification, ruminal bolus, sheep, traceability, transponder
- Published
- 2006
35. Parametric bootstrap for testing model fitting in the proportional hazards framework: an application to the survival analysis of Bruna dels Pirineus beef calves
- Author
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Casellas, J., Tarres, J., Piedrafita, J., and Varona, L.
- Subjects
Beef -- Research ,Monte Carlo method -- Usage ,Cattle ,Zoology and wildlife conservation - Abstract
Given that correct assumptions on the baseline survival function are determinant for the validity of further inferences, specific tools to test the fit of a model to real data become essential in proportional hazards models. In this sense, we have proposed a parametric bootstrap to test the fit of survival models. Monte Carlo simulations are used to generate new data sets from the estimates obtained through the assumed models, and then bootstrap intervals can be established for the survival function along the time space studied. Significant fitting deficiencies are revealed when the real survival function is not included within the bootstrap interval. We tested this procedure in a survival data set of Bruna dels Pirineus beef calves, assuming 4 parametric models (exponential, Weibull, exponential time-dependent, Weibull time-dependent) and the Cox's semiparametric model. Fitting deficiencies were not observed for the Cox's model and the exponential time-dependent model, whereas the Weibull time-dependent model suffered from moderate overestimation at different ages. Thus, the exponential time-dependent model appears to be preferable because of its correct fit for survival data of beef calves and its smaller computational and time requirements. Exponential and Weibull models were completely rejected due to the continuous over- and underestimation of the survival probability reported. Results here highlighted the flexibility of parametric models with time-dependent effects, achieving a fit comparable to nonparametric models. Key words: model fitting, parametric bootstrap, proportional hazard, survival analysis
- Published
- 2006
36. Evaluation of the retention of electronic identification boluses in the forestomachs of cattle
- Author
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Ghirardi, J.J., Caja, G., Garin, D., Casellas, J., and Hernandez-Jover, M.
- Subjects
Calves -- Research ,Calves -- Physiological aspects ,Cattle -- Research ,Cattle -- Physiological aspects ,Rumination -- Research ,Zoology and wildlife conservation - Abstract
A total of 1,203 beef calves were used to evaluate 2 series of electronic identification boluses. Calves were intensively fattened and slaughtered at approximately 1 yr of age. Series 1 (n = 576 calves) consisted of 10 types of boluses with the same external dimensions (o.d. x length: 21 x 68 mm) but varying in weight (11 to 75 g) and specific gravity (0.63 to 3.36). Six boluses were made of ceramic (5 prototypes and 1 commercial bolus) and 4 were tubes made of plastic filled with concrete. Series 2 (n = 627 calves) consisted of 3 prototypes and 5 commercial boluses of different ceramic materials varying in external dimensions (o.d.: 15 to 21 mm; length: 39 to 78 mm), weight (20 to 73 g), and specific gravity (3.00 to 3.87). Boluses were administered to milk-fed calves (2 to 5 wk of age) by using adapted balling guns. To determine the anatomical limit for a bolus passing through the gastrointestinal tract, the size of the reticulo-omasal orifice was measured in 90 male and 62 female fattened calves at slaughter. Three calves in series 1 (0.3%) could not swallow the 21-mm (o.d.) bolus at the first attempt and received the bolus 1 wk later. No problems for early administration were found with thinner boluses (o.d. Key words: cattle, electronic identification, ruminal bolus, traceability, transponder
- Published
- 2006
37. High amino acid variation in the intracellular domain of the pig prolactin receptor (PRLR) and its relation to ovulation rate and piglet survival traits
- Author
-
Tomas, A., Casellas, J., Ramirez, O., Munoz, G., Noguera, J.L., and Sanchez, A.
- Subjects
Swine -- Physiological aspects ,Swine -- Genetic aspects ,Genetic polymorphisms -- Research ,Zoology and wildlife conservation - Abstract
Two polymorphisms of the porcine prolactin receptor (PRLR) gene were previously related to litter size by several authors; however, the magnitude and direction of such effects varied depending on the population analyzed. We have sequenced the complete coding region of the porcine PRLR gene and found 6 nonconservative SNP: C1217T (Leu/[Pro.sub.406]), C1283A (Asp/[Ala.sub.428]), G1439A (Lys/[Arg.sub.480]), T1528A (Met/ [Leu.sub.510]), G1600A (Gly/[Ser.sub.534]), and G1789A (Gly/[Ser.sub.597]), within exon 10 of the gene, which encodes the entire intracytoplasmic domain of the protein. Eight haplotypes were found and were segregating at different frequencies in 6 porcine breeds. The effects of each individual SNP and haplotype were evaluated in an Iberian x Meishan [F.sub.2] population using a univariate mixed-inheritance animal model. Significant effects on the number of corpora lutea were found for PRLR haplotypes (P < 0.012), confirming the previously reported associations of PRLR in this process and highlighting the importance of performing analysis of haplotypes rather than of individual SNP. Suggestive effects or tendencies were found for heart rate at birth (P < 0.10), rectal temperature (P < 0.05), and oxygen saturation (P < 0.10) 1 h after birth, and time to first suckle (P < 0.10). We found greater than expected levels of amino acid variability within the intracellular domain of the porcine PRLR, which have been associated with differences in the number of corpus lutea of sows and the preweaning survivability of piglets. Key words: pig prolactin receptor, piglet survival, polymorphism, reproduction
- Published
- 2006
38. Machine Learning approach to predict Post-ERCP Pancreatitis in the STARK international multicenter prospective cohort study
- Author
-
Archibugi, L., primary, Ciarfaglia, G., additional, Cárdenas-Jaén, K., additional, Poropat, G., additional, Korpela, T., additional, Maisonneuve, P., additional, Aparicio, J., additional, Casellas, J., additional, Arcidiacono, P., additional, Mariani, A., additional, Stimac, D., additional, Hauser, G., additional, Udd, M., additional, Kylänpää, L., additional, Rainio, M., additional, Di Giulio, E., additional, Vanella, G., additional, Lohr, M., additional, Valente, R., additional, Arnelo, U., additional, De Pretis, N., additional, Gabbrielli, A., additional, Brozzi, L., additional, De-Madaria, E., additional, and Capurso, G., additional
- Published
- 2020
- Full Text
- View/download PDF
39. Genetic and environmental factors influencing mortality up to weaning of Bruna dels Pirineus beef calves in mountain areas. A survival analysis
- Author
-
Tarres, J., Casellas, J., and Piedrafita, J.
- Subjects
Beef cattle -- Research ,Beef cattle -- Food and nutrition ,Zoology and wildlife conservation - Abstract
Survival analysis techniques were used to analyze survival up to weaning of beef calves in the Pyrenean mountains areas of Catalonia, Spain. The Kaplan-Meier curve showed that the survival experience was not constant throughout the lactation period, as the mortality rate was more pronounced during the first month of life. The proportional hazards model analysis showed that several factors influenced the instantaneous mortality rate, with the herd-year effect having the strongest influence. Calves born in the first part of the breeding season, from September to February, had the lowest mortality risk (P < 0.001), showing that mortality risk increases as births accumulate. Calves from cows younger than 1,300 d of productive life had a higher risk of mortality (P < 0.05). Unassisted calvings presented the smallest risk of mortality, and mortality risk increased up to five times as birth became more difficult (P < 0.001). This risk also tended to increase slightly when calf birth weight was small (P < 0.10); for bigger calves, no increase of risk was detected, probably because calving difficulty was included in the model. These results suggest the need for improving the environment in the second part of the breeding period and paying more attention to births from younger cows. The survival curve fitted a parametric piecewise exponential function very well, with cut points at 16 and 32 d. The lower risk corresponded to the period of 33 to 180 d, the risk for the periods 17 to 32 d and I to 16 d being multiplied by 7 and 26, respectively. Confirming the robustness of the Cox model, the relative risks estimated for the different factors under this piecewise exponential model or a Weibull time-dependent model were similar to those reported above, as well as to those estimated under a frailty model, including the sire as a random effect. The modal estimates of sire variance under different baseline functions were close to 0.3, although the standard errors were very large. At weaning, the heritability estimate in the binary scale reached a value of only 0.037 because the survival at weaning was very high (96.9%) in this population. Nevertheless, in populations with a higher mortality, the inclusion of survival to weaning in the breeding objective might be justified. Overall, these results show that survival analysis is a powerful tool to analyze the mortality curve until weaning of beef calves. Key Words: Beef Cattle, Heritability, Survival Analysis, Survival to Weaning
- Published
- 2005
40. Bayes factor analysis for the genetic background of physiological and vitality variables of [F.sub.2] Iberian x Meishan newborn piglets
- Author
-
Varona, L., Casellas, J., Piedrafita, J., Sanchez, A., Garcia-Casado, P., Arque, M., and Noguera, J.L.
- Subjects
Swine -- Research ,Genetic research ,Zoology and wildlife conservation - Abstract
The Bayes factor (BF) procedure was applied to examine the additive genetic component of several physiological and vitality variables for newborn pigs. Nine variables were studied: heart rate, arterial oxygen saturation, rectal temperature (all at birth and 60 min later), birth weight, interval between birth and first teats contact, and interval between birth and first colostrum intake. The available numbers of data ranged from 288 (heart rate at 60 min) to 839 records (birth weight) from [F.sub.2] Iberian x Meishan newborn pigs. We compared a model with zero heritability (nonheritable) with the one where the additive genetic background was included. The BF was used to discriminate between both candidate models. Very strong evidence of genetic background was detected for heart rate 60 min after birth (BF = 48.90), and strong evidence was detected for rectal temperature at birth (BF = 13.82). Posterior modes (means) of heritabilities were 0.29 (0.32) and 0.40 (0.39), respectively. In addition, substantial evidence of absence of genetic background was detected for arterial oxygen saturation at birth. Key Words: Bayes Factor, Neonate Metabolism, Survival, Vitality
- Published
- 2005
41. Viability of Iberian x Meishan [F.sub.2] newborn pigs. II. Survival analysis up to weaning
- Author
-
Casellas, J., Noguera, J.L., Varona, L., Sanchez, A., Arque, M., and Piedrafita, J.
- Subjects
Swine -- Research ,Zoology and wildlife conservation - Abstract
Iberian x Meishan [F.sub.2] piglet's preweaning survivability was analyzed using categorical data regression procedures within the proportional hazards assumption. A frailty sire model was assumed with the litter effect treated as an additional random source of variation. Moreover, the relative birth weight within litter and the litter effect were considered time-dependent covariates that changed their values in the second day of life due to cross fostering carried out to standardize litters. Six variables had a significant effect on survivability: birth weight (P < 0.01), relative birth weight within litter (P < 0.001), rectal temperature 60 min after birth (P < 0.01), type of presentation at birth (P < 0.05), presence of stillbirths (P < 0.001), and presence of mummified fetuses (P < 0.001). Small piglets ( Key Words: Categorical Survival Analysis, [F.sub.2] Piglets, Preweaning Survival, Proportional Hazards
- Published
- 2004
42. Viability of Iberian x Meishan [F.sub.2] newborn pigs. I. Analysis of physiological and vitality variables
- Author
-
Casellas, J., Rauw, W.M., Piedrafita, J., Sanchez, A., Arque, M., and Noguera, J.L.
- Subjects
Swine -- Research ,Zoology and wildlife conservation - Abstract
Eight physiological and vitality variables related to the first minutes of the life of Iberian x Meishan [F.sub.2] piglets were analyzed. Variables included rectal temperature, arterial oxygen saturation, heart rate (all were monitored at birth and 60 min later), time to reach the udder, and time to the first colostrum intake. Litter effect within boar, a random source of variation, influenced all variables, whereas the random boar effect was not significant for heart rate and arterial oxygen saturation at birth and the time to reach the udder. Birth weight influenced rectal temperature at birth (P < 0.01) and 60 min later (P < 0.001), arterial oxygen saturation 1 h after birth (P < 0.05), heart rate 1 h after birth (P < 0.001), time to reach the udder (P < 0.05), and time to the first suckle (P < 0.01), whereas viability score influenced rectal temperatures (at birth and 60 min later; P < 0.001), and time to reach the udder (P < 0.001) and to suckle (P < 0.001). Finally, the order of birth showed significant effects for rectal temperature 1 h after birth (P < 0.001) and time to first colostrum intake (P < 0.001). Correlation coefficients between physiological variables were generally low, with the exception of the ones for rectal temperature 1 h after birth and arterial oxygen saturation 1 h after birth (0.38; P < 0.001), and for rectal temperature at birth and rectal temperature i h after birth (0.34; P < 0.001). Times to reach the udder and to suckle were highly correlated (0.67; P < 0.001) and also were moderately and negatively correlated with rectal temperature 1 h after birth (-0.36 and -0.38 respectively; P < 0.001). Heart rates at birth and i h later, as well as arterial oxygen saturation at birth and 1 h later, were not correlated, showing that the values at birth do not necessarily provide information about the physiological status of the pig 1 h after birth. The recording of physiological variables, birth weight, and viability score may be useful to identify weak piglets quickly and to establish palliative measures. Key Words: Physiological Variables, Piglets, Postnatal Period, Viability
- Published
- 2004
43. Recombination rates across porcine autosomes inferred from high-density linkage maps
- Author
-
Muñoz, M., Alves, E., Ramayo-Caldas, Y., Casellas, J., Rodríguez, C., Folch, J. M., Silió, L., and Fernández, A. I.
- Published
- 2012
- Full Text
- View/download PDF
44. Comparative In Vitro Activity of Trovafloxacin Against Gram-Positive and Gram-Negative Clinical Isolates from Argentina
- Author
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Sucari, Adriana, Stepanik, D., Casellas, J. M., Tomé, G., Clara, L., Marín, M., Rossi, A., Galas, M., Smayevsky, J., Dufranc, L., Lorenzo, H., de Vedia, L., and López, H.
- Published
- 1999
- Full Text
- View/download PDF
45. Quantitative trait loci for fatness at growing and reproductive stages in Iberian × Meishan F2 sows
- Author
-
Tomás, A., Ramírez, O., Casellas, J., Muñoz, G., Sánchez, A., Barragán, C., Arqué, M., Riart, I., Óvilo, C., Noguera, J. L., Amills, M., and Rodríguez, C.
- Published
- 2011
- Full Text
- View/download PDF
46. Bootstrap test for proportional hazard assumption on time-independent systematic effects of longevity data
- Author
-
Casellas, J.
- Published
- 2011
- Full Text
- View/download PDF
47. Discovering lethal alleles across the turkey genome using a transmission ratio distortion approach
- Author
-
Abdalla, E. A., primary, Id‐Lahoucine, S., additional, Cánovas, A., additional, Casellas, J., additional, Schenkel, F. S., additional, Wood, B. J., additional, and Baes, C. F., additional
- Published
- 2020
- Full Text
- View/download PDF
48. Discriminating between allele‐ and genotype‐specific transmission ratio distortion
- Author
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Casellas, J., primary, Id‐Lahoucine, S., additional, and Cánovas, A., additional
- Published
- 2020
- Full Text
- View/download PDF
49. Skew distribution of founder-specific inbreeding depression effects on the longevity of Landrace sows
- Author
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CASELLAS, J., VARONA, L., IBÁÑEZ-ESCRICHE, N., QUINTANILLA, R., and NOGUERA, J. L.
- Published
- 2009
50. Effect of medium- and long-chain triglyceride supplementation on small newborn-pig survival
- Author
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Casellas, J., Casas, X., Piedrafita, J., and Manteca, X.
- Published
- 2005
- Full Text
- View/download PDF
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