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25 results on '"Casella, Daniel P."'

3. Upper pole pathologies in duplex kidneys: an analysis of predictive factors for surgery and urinary tract infections from the Mid-Atlantic Pediatric Academic Consortium

Author

Morgan, Kathryn E., primary, Yeaman, Clinton, additional, Ross, Sherry S., additional, Michael, Jamie, additional, Pohl, Hans G., additional, Casella, Daniel P., additional, Sprague, Bruce M., additional, Zee, Rebecca S., additional, Herndon, C.D. Anthony, additional, and Kern, Nora G., additional

Published
2022
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12. Purine Biosynthesis Metabolically Constrains Intracellular Survival of Uropathogenic Escherichia coli

Author

Shaffer, Carrie L., primary, Zhang, Ellisa W., additional, Dudley, Anne G., additional, Dixon, Beverly R. E. A., additional, Guckes, Kirsten R., additional, Breland, Erin J., additional, Floyd, Kyle A., additional, Casella, Daniel P., additional, Algood, Holly M. Scott, additional, Clayton, Douglass B., additional, and Hadjifrangiskou, Maria, additional

Published
2017
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13. Posterior Urethral Valves: Renal Failure and Prenatal Treatment

Author

Casella, Daniel P., Tomaszewski, Jeffrey J., and Ost, Michael C.

Subjects
Article Subject, urologic and male genital diseases
Abstract

Posterior urethral valves occur in 1 : 5000 live births. Despite the high prevalence, the few children that survive do poorly, with over 50% progressing to ESRD in 10 years. The gold standard for post-natal diagnosis is voiding cystourethrography, while pre-natal diagnosis is dependent on routine screening ultrasonography. Despite the ability to identify features of bladder outlet obstruction early in fetal development, there is no consensus on how to incorporate early detection into current screening protocols. There has yet to be a marker that allows prediction of obstruction in the absence of or prior to radiographic evidence of obstruction. With our current screening strategy, the majority of interventions are performed well after irreversible damage has occurred. Improved mortality and long term morbidity from posterior urethral valves and congenital bladder outlet obstruction will likely remain unchanged until it is possible to intervene prior to the onset of irreversible renal damage. New biologic markers and improved instrumentation will allow for more effective diagnosis and intervention at earlier stages of fetal development.

Published
2012
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20. Nonverbal Skill, Personal Charisma, and Initial Attraction

Author

Friedman, Howard S., Riggio, Ronald E., and Casella, Daniel F.

Abstract

The study of initial attraction has given insufficient attention to the influence of nonverbal expressiveness. This study examined the relative effects of expressive nonverbal skills and physical attractiveness on impressions made in initial encounters. Physical attractiveness is of known importance in the initial stages of a relationship; yet dynamic nonverbal cues of emotion may also have a significant impact. Fifty-four undergraduates were administered standard measures of nonverbal expressiveness, self-monitoring, and extroversion, and they were surreptitiously videotaped while entering a laboratory and meeting new people. Subjects were rated by separate groups of observers on scales of likability and physical attractiveness. The results indicated that emotionally expressive, extroverted, and physically attractive subjects were evaluated more favorably in these initial encounters than were subjects scoring low on these dimensions. The relationships between expressivity/extroversion and initial likability were independent of the effects of physical attractiveness. These results suggest that conceptions of overall attractiveness need to move beyond the physical qualities to include dynamic, emotional aspects.

Published
1988
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21. Purine Biosynthesis Metabolically Constrains Intracellular Survival of Uropathogenic Escherichia coli

Author

Shaffer, Carrie L., Zhang, Ellisa W., Dudley, Anne G., Dixon, Beverly R. E. A., Guckes, Kirsten R., Breland, Erin J., Floyd, Kyle A., Casella, Daniel P., Algood, Holly M. Scott, Clayton, Douglass B., and Hadjifrangiskou, Maria

Abstract

ABSTRACTThe ability to de novosynthesize purines has been associated with the intracellular survival of multiple bacterial pathogens. Uropathogenic Escherichia coli(UPEC), the predominant cause of urinary tract infections, undergoes a transient intracellular lifestyle during which bacteria clonally expand into multicellular bacterial communities within the cytoplasm of bladder epithelial cells. Here, we characterized the contribution of the conserved de novopurine biosynthesis-associated locus cvpA-purFto UPEC pathogenesis. Deletion of cvpA-purF, or of purFalone, abolished de novopurine biosynthesis but did not impact bacterial adherence properties in vitroor in the bladder lumen. However, upon internalization by bladder epithelial cells, UPEC deficient in de novopurine biosynthesis was unable to expand into intracytoplasmic bacterial communities over time, unless it was extrachromosomally complemented. These findings indicate that UPEC is deprived of purine nucleotides within the intracellular niche and relies on de novopurine synthesis to meet this metabolic requirement.

Published
2016
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24. Ureteral Development: New Molecular Mechanisms and Understanding of Ureteropelvic Junction Obstruction.

Author

Casella, Daniel P.

Subjects
*HYDRONEPHROSIS, *FIBROSIS, *PACEMAKER cells, *SMOOTH muscle, *HYPERTROPHY
Abstract

The article discusses histological findings in understanding ureteropelvic junction (UPJ) obstruction, deemed a common cause of prenatal hydronephrosis and renal dysfunction. It cites histological abnormalities including altered neural patterning, changes in the pacemaker cells of Cajal and smooth muscle defects ranging from hypertrophy to fibrosis with smooth muscle apoptosis. It notes that the most poorly understood histological finding is alterations in neural patterning.

Published
2012

25. Natural orifice transluminal endoscopic surgery (NOTES): current experience and urologic applications.

Author

Casella DP, Smaldone MC, and Averch TD

Subjects
Animals, Colon, Female, Humans, Male, Stomach, Swine, Urinary Bladder, Vagina, Endoscopy methods, Urologic Surgical Procedures methods
Abstract

Natural orifice transluminal endoscopic surgery (NOTES) has attracted considerable recent attention for its potential to allow traditional abdominal procedures to be performed without a transabdominal incision. With considerable experience in the development and application of minimally invasive techniques, urologists have played a significant role in early experimental NOTES efforts and have contributed to early investigations in human subjects accordingly. However, adoption of these techniques has been limited due to cumbersome endoscopic equipment and concerns regarding peritonitis from failed viscerotomy closure. Experience with use of NOTES in human subjects is limited, and studies comparing NOTES to conventional minimally invasive techniques are lacking. Until adequate endoscopes are developed to facilitate a pure NOTES approach, multiple portals of entry will be necessary to facilitate both urologic and non-urologic reconstructive and extirpative procedures. Our aim is to evaluate NOTES techniques, portals of entry, early clinical experiences, and the application of NOTES to urologic surgery.

Published
2010

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