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1. Age-specific nasal epithelial responses to SARS-CoV-2 infection

Author

Woodall, Maximillian N. J., Cujba, Ana-Maria, Worlock, Kaylee B., Case, Katie-Marie, Masonou, Tereza, Yoshida, Masahiro, Polanski, Krzysztof, Huang, Ni, Lindeboom, Rik G. H., Mamanova, Lira, Bolt, Liam, Richardson, Laura, Cakir, Batuhan, Ellis, Samuel, Palor, Machaela, Burgoyne, Thomas, Pinto, Andreia, Moulding, Dale, McHugh, Timothy D., Saleh, Aarash, Kilich, Eliz, Mehta, Puja, O’Callaghan, Chris, Zhou, Jie, Barclay, Wendy, De Coppi, Paolo, Butler, Colin R., Cortina-Borja, Mario, Vinette, Heloise, Roy, Sunando, Breuer, Judith, Chambers, Rachel C., Heywood, Wendy E., Mills, Kevin, Hynds, Robert E., Teichmann, Sarah A., Meyer, Kerstin B., Nikolić, Marko Z., and Smith, Claire M.

Published
2024
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2. Author Correction: Age-specific nasal epithelial responses to SARS-CoV-2 infection

Author

Woodall, Maximillian N. J., Cujba, Ana-Maria, Worlock, Kaylee B., Case, Katie-Marie, Masonou, Tereza, Yoshida, Masahiro, Polanski, Krzysztof, Huang, Ni, Lindeboom, Rik G. H., Mamanova, Lira, Bolt, Liam, Richardson, Laura, Cakir, Batuhan, Ellis, Samuel, Palor, Machaela, Burgoyne, Thomas, Pinto, Andreia, Moulding, Dale, McHugh, Timothy D., Saleh, Aarash, Kilich, Eliz, Mehta, Puja, O’Callaghan, Chris, Zhou, Jie, Barclay, Wendy, De Coppi, Paolo, Butler, Colin R., Cortina-Borja, Mario, Vinette, Heloise, Roy, Sunando, Breuer, Judith, Chambers, Rachel C., Heywood, Wendy E., Mills, Kevin, Hynds, Robert E., Teichmann, Sarah A., Meyer, Kerstin B., Nikolić, Marko Z., and Smith, Claire M.

Published
2024
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3. Salivary IgA and vimentin differentiate in vitro SARS-CoV-2 infection: A study of 290 convalescent COVID-19 patients

Author

Ellis, Samuel, Way, Rosie, Nel, Miranda, Burleigh, Alice, Doykov, Ivan, Kembou-Ringert, Japhette, Woodall, Maximillian, Masonou, Tereza, Case, Katie-Marie, Ortez, Arturo Torres, McHugh, Timothy D., Casal, Antonio, McCoy, Laura E., Murdan, Sudaxshina, Hynds, Robert E., Gilmour, Kimberly C., Grandjean, Louis, Cortina-Borja, Mario, Heywood, Wendy E, Mills, Kevin, and Smith, Claire M.

Published
2024
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4. Cell-intrinsic differences between human airway epithelial cells from children and adults

Author

Maughan, Elizabeth F., Hynds, Robert E., Pennycuick, Adam, Nigro, Ersilia, Gowers, Kate H.C., Denais, Celine, Gómez-López, Sandra, Lazarus, Kyren A., Orr, Jessica C., Pearce, David R., Clarke, Sarah E., Lee, Dani Do Hyang, Woodall, Maximillian N.J., Masonou, Tereza, Case, Katie-Marie, Teixeira, Vitor H., Hartley, Benjamin E., Hewitt, Richard J., Al Yaghchi, Chadwan, Sandhu, Gurpreet S., Birchall, Martin A., O’Callaghan, Christopher, Smith, Claire M., De Coppi, Paolo, Butler, Colin R., and Janes, Sam M.

Published
2022
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5. The emergence of goblet inflammatory or ITGB6hinasal progenitor cells determines age-associated SARS-CoV-2 pathogenesis

Author

Woodall, Maximillian, primary, Cujba, Ana-Maria, additional, Worlock, Kaylee B., additional, Case, Katie-Marie, additional, Masonou, Tereza, additional, Yoshida, Masahiro, additional, Polanski, Krzysztof, additional, Huang, Ni, additional, Lindeboom, Rik G. H., additional, Mamanova, Lira, additional, Bolt, Liam, additional, Richardson, Laura, additional, Ellis, Samuel, additional, Palor, Machaela, additional, Burgoyne, Thomas, additional, Pinto, Andreia, additional, Moulding, Dale, additional, McHugh, Timothy D., additional, Saleh, Aarash, additional, Kilich, Eliz, additional, Mehta, Puja, additional, O’Callaghan, Chris, additional, Zhou, Jie, additional, Barclay, Wendy, additional, Coppi, Paolo De, additional, Butler, Colin R., additional, Vinette, Heloise, additional, Roy, Sunando, additional, Breuer, Judith, additional, Chambers, Rachel C., additional, Heywood, Wendy E., additional, Mills, Kevin, additional, Hynds, Robert E., additional, Teichmann, Sarah A., additional, Meyer, Kerstin B., additional, Nikolić, Marko Z., additional, and Smith, Claire M., additional

Published
2023
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8. Cell-intrinsic differences between human airway epithelial cells from children and adults

Author

Maughan, Elizabeth F., primary, Hynds, Robert E., additional, Pennycuick, Adam, additional, Nigro, Ersilia, additional, Gowers, Kate H.C., additional, Denais, Celine, additional, Gómez-López, Sandra, additional, Lazarus, Kyren A., additional, Orr, Jessica C., additional, Pearce, David R., additional, Clarke, Sarah E., additional, Lee, Dani Do Hyang, additional, Woodall, Maximillian N. J., additional, Masonou, Tereza, additional, Case, Katie-Marie, additional, Teixeira, Vitor H., additional, Hartley, Benjamin E., additional, Hewitt, Richard J., additional, Yaghchi, Chadwan Al, additional, Sandhu, Gurpreet S., additional, Birchall, Martin A., additional, O’Callaghan, Christopher, additional, Smith, Claire M., additional, De Coppi, Paolo, additional, Butler, Colin R., additional, and Janes, Sam M., additional

Published
2020
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11. Salivary IgA and vimentin differentiate in vitroSARS-CoV-2 infection: A study of 290 convalescent COVID-19 patients

Author

Ellis, Samuel, Way, Rosie, Nel, Miranda, Burleigh, Alice, Doykov, Ivan, Kembou-Ringert, Japhette, Woodall, Maximillian, Masonou, Tereza, Case, Katie-Marie, Ortez, Arturo Torres, McHugh, Timothy D., Casal, Antonio, McCoy, Laura E., Murdan, Sudaxshina, Hynds, Robert E., Gilmour, Kimberly C., Grandjean, Louis, Cortina-Borja, Mario, Heywood, Wendy E, Mills, Kevin, and Smith, Claire M.

Abstract

SARS-CoV-2 initially infects cells in the nasopharynx and oral cavity. The immune system at these mucosal sites plays a crucial role in minimizing viral transmission and infection. To develop new strategies for preventing SARS-CoV-2 infection, this study aimed to identify proteins that protect against viral infection in saliva.

Published
2023
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17. Cell-intrinsic differences between human airway epithelial cells from children and adults

Author

Elizabeth F. Maughan, Robert E. Hynds, Adam Pennycuick, Ersilia Nigro, Kate H.C. Gowers, Celine Denais, Sandra Gómez-López, Kyren A. Lazarus, Jessica C. Orr, David R. Pearce, Sarah E. Clarke, Dani Do Hyang Lee, Maximillian N. J. Woodall, Tereza Masonou, Katie-Marie Case, Vitor H. Teixeira, Benjamin E. Hartley, Richard J. Hewitt, Chadwan Al Yaghchi, Gurpreet S. Sandhu, Martin A. Birchall, Christopher O’Callaghan, Claire M. Smith, Paolo De Coppi, Colin R. Butler, Sam M. Janes, Maughan, Elizabeth F, Hynds, Robert E, Pennycuick, Adam, Nigro, Ersilia, Gowers, Kate H C, Denais, Celine, Gómez-López, Sandra, Lazarus, Kyren A, Orr, Jessica C, Pearce, David R, Clarke, Sarah E, Lee, Dani Do Hyang, Woodall, Maximillian N J, Masonou, Tereza, Case, Katie-Marie, Teixeira, Vitor H, Hartley, Benjamin E, Hewitt, Richard J, Al Yaghchi, Chadwan, Sandhu, Gurpreet S, Birchall, Martin A, O'Callaghan, Christopher, Smith, Claire M, De Coppi, Paolo, Butler, Colin R, and Janes, Sam M

Subjects
Molecular biology, Cell, Biology, Pediatrics, MECHANISMS, 03 medical and health sciences, Basal (phylogenetics), 0302 clinical medicine, REGENERATION, Medical science, medicine, Progenitor cell, GENE-EXPRESSION, 030304 developmental biology, REPAIR, 0303 health sciences, Science & Technology, Multidisciplinary, Lung, Cell growth, Epithelium, In vitro, Multidisciplinary Sciences, medicine.anatomical_structure, Immunology, Science & Technology - Other Topics, GROWTH, Respiratory epithelium, STEM-CELLS, LUNG, 030217 neurology & neurosurgery
Abstract

SummaryThe airway epithelium is a key protective barrier, the integrity of which is preserved by the self-renewal and differentiation of basal stem cells. Epithelial cells are central to the pathogenesis of multiple lung diseases. In chronic lung diseases, increasing age is a principle risk factor. Few studies have explored the differences between airway epithelial cells in children and adults and how the function of basal stem cells changes during ageing is poorly understood. Here, we analyze airway epithelial cells from children and adults in homeostatic conditions (laser capture-microdissected whole epithelium and fluorescence-activated cell-sorted basal cells) and in proliferation-inducing cell culture conditions. We find that, while the cellular composition of the pediatric and adult tracheobronchial epithelium is broadly similar, in cell culture, pediatric airway epithelial cells displayed higher colony-forming ability, sustained in vitro growth and outcompeted adult cells in competitive proliferation assays. In RNA sequencing experiments, we observed potentially important differences between epithelium from children and adults, including higher baseline interferon-associated gene expression in pediatric epithelium. Our results demonstrate cell-intrinsic differences in transcriptional profile and regenerative capacity between proximal airway epithelial cells of children and adults.Graphical abstract

Published
2022

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