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1. Persistence, effectiveness and safety of ustekinumab and vedolizumab therapy for complex perianal fistula in Crohn's disease: The HEAL study from GETECCU

Author

Casanova, María José, Caballol, Berta, García, María José, Mesonero, Francisco, Rubín de Célix, Cristina, Suárez-Álvarez, Patricia, Ferreiro-Iglesias, Rocío, Martín-Rodríguez, María del Mar, de Francisco, Ruth, Varela-Trastoy, Pilar, Bastida, Guillermo, Carrillo-Palau, Marta, Núñez-Ortiz, Andrea, Ramírez-de la Piscina, Patricia, Ceballos, Daniel, Hervías-Cruz, Daniel, Muñoz-Pérez, Roser, Velayos, Benito, Bermejo, Fernando, Busquets, David, Cabacino, Manuel, Camo-Monterde, Patricia, Marín-Jiménez, Ignacio, Muñoz, Carmen, de la Peña-Negro, Luisa Carmen, Sierra-Moros, Eva, Barrio, Jesús, Brunet-Mas, Eduard, Bujanda, Luis, Cañete, Fiorella, Gomollón, Fernando, Manceñido-Marcos, Noemí, Rodríguez-Lago, Iago, Rodríguez-Grau, María Carmen, Sicilia, Beatriz, Torra-Alsina, Sandra, Arranz-Hernández, Laura, Carpio, Daniel, García-Sepulcre, Mariana Fe, González-Muñoza, Carlos, Huguet, José María, Márquez-Mosquera, Lucía, López-Serrano, María Pilar, Ponferrada-Díaz, Ángel, Chaparro, María, and Gisbert, Javier P.

Published
2024
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3. Trends in Targeted Therapy Usage in Inflammatory Bowel Disease: TRENDY Study of ENEIDA

Author

Gómez-Labrador, Celia, primary, Ricart, Elena, additional, Iborra, Marisa, additional, Iglesias, Eva, additional, Martín-Arranz, María Dolores, additional, de Castro, Luisa, additional, De Francisco, Ruth, additional, García-Alonso, Francisco Javier, additional, Sanahuja, Ana, additional, Gargallo-Puyuelo, Carla J., additional, Mesonero, Francisco, additional, Casanova, María José, additional, Mañosa, Míriam, additional, Rivero, Montserrat, additional, Calvo, Marta, additional, Sierra-Ausin, Mónica, additional, González-Muñoza, Carlos, additional, Calvet, Xavier, additional, García-López, Santiago, additional, Guardiola, Jordi, additional, Arias García, Lara, additional, Márquez-Mosquera, Lucía, additional, Gutiérrez, Ana, additional, Zabana, Yamile, additional, Navarro-Llavat, Mercè, additional, Lorente Poyatos, Rufo, additional, Piqueras, Marta, additional, Torrealba, Leyanira, additional, Bermejo, Fernando, additional, Ponferrada-Díaz, Ángel, additional, Pérez-Calle, José L., additional, Acosta, Manuel Barreiro-de, additional, Tejido, Coral, additional, Cabriada, José Luis, additional, Marín-Jiménez, Ignacio, additional, Roncero, Óscar, additional, Ber, Yolanda, additional, Fernández-Salazar, Luis, additional, Camps Aler, Blau, additional, Lucendo, Alfredo J., additional, Llaó, Jordina, additional, Bujanda, Luis, additional, Muñoz Villafranca, Carmen, additional, Domènech, Eugeni, additional, Chaparro, María, additional, and Gisbert, Javier P., additional

Published
2024
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6. ECCO Guidelines on Therapeutics in Crohn's Disease: Medical Treatment.

Author

Gordon, Hannah, Minozzi, Silvia, Kopylov, Uri, Verstockt, Bram, Chaparro, María, Buskens, Christianne, Warusavitarne, Janindra, Agrawal, Manasi, Allocca, Mariangela, Atreya, Raja, Battat, Robert, Bettenworth, Dominik, Bislenghi, Gabriele, Brown, Steven Ross, Burisch, Johan, Casanova, María José, Czuber-Dochan, Wladyslawa, Groof, Joline de, El-Hussuna, Alaa, and Ellul, Pierre

Published
2024
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7. Need for therapeutic escalation in patients with refractory ulcerative proctitis: Results from the PROCU study of the ENEIDA registry.

Author

Ferreiro‐Iglesias, Rocío, Porto Silva, Sol, Marín, Sandra, Casanova, María José, Mañosa, Míriam, González‐Muñoza, Carlos, de Francisco, Ruth, Caballol, Berta, Arias, Lara, Piqueras, Marta, Zabana, Yamile, Rivero, Montserrat, Calvet, Xavier, Mesonero, Francisco, Varela Trastoy, Pilar, Busta Nistal, Reyes, Gómez Perosanz, Raquel, Vega, Pablo, Gonzalez‐Vivo, Maria, and Iborra, Marisa

Subjects
CLINICAL trials, ULCERATIVE colitis, RANDOMIZED controlled trials, IMMUNOSUPPRESSIVE agents, BIOLOGICALS
Abstract

Summary: Background: Ulcerative proctitis (UP) can have a milder, less aggressive course than left‐sided colitis or extensive colitis. Therefore, immunosuppressants tend to be used less in patients with this condition. Evidence, however, is scarce because these patients are excluded from randomised controlled clinical trials. Our aim was to describe the characteristics of patients with refractory UP and their disease‐related complications, and to identify the need for immunosuppressive therapies. Methods: We identified patients with UP from the prospective ENEIDA registry sponsored by the GETECCU. We evaluated socio‐demographic data and complications associated with immunosuppression. We defined immunosuppression as the use of immunomodulators, biologics and/or small molecules. We used logistic regression to identify factors associated with immunosuppressive therapy. Results: From a total of 34,716 patients with ulcerative colitis, we identified 6281 (18.1%) with UP; mean ± SD age 53 ± 15 years, average disease duration of 12 ± 9 years. Immunosuppression was prescribed in 11% of patients, 4.2% needed one biologic agent and 1% needed two; 2% of patients required hospitalisation, and 0.5% underwent panproctocolectomy or subtotal colectomy. We identified 0.2% colorectal tumours and 5% extracolonic tumours. Patients with polyarthritis (OR 3.56, 95% CI 1.86–6.69; p < 0.001) required immunosuppressants. Conclusions: Among patients with refractory UP, 11% required immunosuppressant therapy, and 4.2% required at least one biologic agent. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Effectiveness and safety of a third‐line rescue treatment for acute severe ulcerative colitis refractory to infliximab or ciclosporin (REASUC study)

Author

García, María José, primary, Riestra, Sabino, additional, Amiot, Aurelien, additional, Julsgaard, Mette, additional, García de la Filia, Irene, additional, Calafat, Margalida, additional, Aguas, Mariam, additional, de la Peña, Luisa, additional, Roig, Cristina, additional, Caballol, Berta, additional, Casanova, María José, additional, Farkas, Klaudia, additional, Boysen, Trine, additional, Bujanda, Luis, additional, Cuarán, Camila, additional, Dobru, Daniela, additional, Fousekis, Fotios, additional, Gargallo‐Puyuelo, Carla Jerusalén, additional, Savarino, Edoardo, additional, Calvet, Xavier, additional, Huguet, José María, additional, Kupcinskas, Limas, additional, López‐Cardona, Julia, additional, Raine, Tim, additional, van Oostrom, Joep, additional, Gisbert, Javier P., additional, and Chaparro, María, additional

Published
2024
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12. Serum and Urine Metabolomic Profiling of Newly Diagnosed Treatment-Naïve Inflammatory Bowel Disease Patients.

Author

Aldars-García, Laila, Gil-Redondo, Rubén, Embade, Nieves, Riestra, Sabino, Rivero, Montserrat, Gutiérrez, Ana, Rodríguez-Lago, Iago, Fernández-Salazar, Luis, Ceballos, Daniel, Benítez, José Manuel, Aguas, Mariam, Baston-Rey, Iria, Bermejo, Fernando, Casanova, María José, Lorente, Rufo, Ber, Yolanda, Ginard, Daniel, Esteve, María, Francisco, Ruth de, and García, María José

Published
2024
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13. Antitumor Necrosis Factor Agents to Treat Endoscopic Postoperative Recurrence of Crohnʼs Disease: A Nationwide Study With Propensity-Matched Score Analysis

Author

Cañete, Fiorella, Mañosa, Míriam, Pérez-Martínez, Isabel, Barreiro-de Acosta, Manuel, González-Sueyro, Ramiro C., Nos, Pilar, Iglesias-Flores, Eva, Gutiérrez, Ana, Bujanda, Luis, Gordillo, Jordi, Ríos León, Raquel, Casanova, María José, Villoria, Albert, Rodríguez-Lago, Iago, López Serrano, Pilar, García-Herola, Antonio, Ramírez-de la Piscina, Patricia, Navarro-Llavat, Mercè, Taxonera, Carlos, Barrio, Jesús, Ramos, Laura, Navarro, Pablo, Benítez-Leiva, Olga, Calafat, Margalida, and Domènech, Eugeni

Published
2020
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14. Effectiveness and Safety of the Sequential Use of a Second and Third Anti-TNF Agent in Patients With Inflammatory Bowel Disease: Results From the Eneida Registry

Author

Casanova, María José, Chaparro, María, Mínguez, Miguel, Ricart, Elena, Taxonera, Carlos, García-López, Santiago, Guardiola, Jordi, López-San Román, Antonio, Iglesias, Eva, Beltrán, Belén, Sicilia, Beatriz, Vera, María Isabel, Hinojosa, Joaquín, Riestra, Sabino, Domènech, Eugeni, Calvet, Xavier, Pérez-Calle, José Lázaro, Martín-Arranz, María Dolores, Aldeguer, Xavier, Rivero, Montserrat, Monfort, David, Barrio, Jesús, Esteve, María, Márquez, Lucía, Lorente, Rufo, García-Planella, Esther, de Castro, Luisa, Bermejo, Fernando, Merino, Olga, Rodríguez-Pérez, Antonio, Martínez-Montiel, Pilar, Van Domselaar, Manuel, Alcaín, Guillermo, Domínguez-Cajal, Manuel, Muñoz, Carmen, Gomollón, Fernando, Fernández-Salazar, Luis, García-Sepulcre, Mariana Fe, Rodríguez-Lago, Iago, Gutiérrez, Ana, Argüelles-Arias, Federico, Rodriguez, Cristina, Rodríguez, Gloria Esther, Bujanda, Luis, Llaó, Jordina, Varela, Pilar, Ramos, Laura, Huguet, José María, Almela, Pedro, Romero, Patricia, Navarro-Llavat, Mercè, Abad, Águeda, Ramírez-de la Piscina, Patricia, Lucendo, Alfredo J, Sesé, Eva, Madrigal, Rosa Eva, Charro, Mara, García-Herola, Antonio, Pajares, Ramón, Khorrami, Sam, and Gisbert, Javier P

Published
2020
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15. Comparative Study of the Effectiveness of Vedolizumab Versus Ustekinumab After Anti-TNF Failure in Crohn’s Disease (Versus-CD): Data from the ENEIDA Registry

Author

García, María José, primary, Rivero, Montserrat, additional, Fernández-Clotet, Agnès, additional, de Francisco, Ruth, additional, Sicilia, Beatriz, additional, Mesonero, Francisco, additional, de Castro, María Luisa, additional, Casanova, María José, additional, Bertoletti, Federico, additional, García-Alonso, Francisco Javier, additional, López-García, Alicia, additional, Vicente, Raquel, additional, Calvet, Xavier, additional, Barreiro-de Acosta, Manuel, additional, Ferrer Rosique, Juan, additional, Varela Trastoy, Pilar, additional, Nuñez, Alejandro, additional, Ricart, Elena, additional, Riestra, Sabino, additional, Arias García, Lara, additional, Rodríguez, María, additional, Arranz, Laura, additional, Pajares, Ramón, additional, Mena, Raquel, additional, Calafat, Margalida, additional, Camo, Patricia, additional, Bermejo, Fernando, additional, Ponferrada, Ángel, additional, Madrigal, Rosa Eva, additional, Llaó, Jordina, additional, Sesé, Eva, additional, Sánchez, Eugenia, additional, Pineda Mariño, Juan Ramón, additional, González Muñoza, Carlos, additional, Carbajo López, Ana Yaiza, additional, Julián, Ana Belén, additional, Villoria Ferrer, Albert, additional, Baston-Rey, Iria, additional, Jara, Lorena, additional, Almela, Pedro, additional, Codesido, Laura, additional, de la Maza, Saioa, additional, Leal, Carles, additional, Caballol, Berta, additional, Pérez-Martínez, Isabel, additional, Vinuesa Campo, Raquel, additional, Crespo, Javier, additional, Domènech, Eugeni, additional, Chaparro, María, additional, and Gisbert, Javier P, additional

Published
2023
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16. Benefits of Paediatric to Adult Transition Programme in Inflammatory Bowel Disease: The BUTTERFLY Study of GETECCU and SEGHNP

Author

Rubín de Célix, Cristina, primary, Martín-de-Carpi, Javier, additional, Pujol-Muncunill, Gemma, additional, Palomino, Laura María, additional, Velasco Rodríguez-Belvís, Marta, additional, Martín-Masot, Rafael, additional, Navas-López, Víctor Manuel, additional, Ricart, Elena, additional, Casanova, María José, additional, Rodríguez-Martínez, Alejandro, additional, Leo-Carnerero, Eduardo, additional, Alcaraz, Alba, additional, Mañosa, Miriam, additional, Hernández, Vicent, additional, Cobelas Cobelas, María Consuelo, additional, Sánchez, César, additional, Menchén, Luis, additional, Mesonero, Francisco, additional, Barreiro-De Acosta, Manuel, additional, Martinón-Torres, Nazareth, additional, Tejido Sandoval, Coral, additional, Rendo Vázquez, Alicia, additional, Corsino, Pilar, additional, Vicente, Raquel, additional, Hernández-Camba, Alejandro, additional, Alberto Alonso, José Ramón, additional, Alonso-Abreu, I., additional, Castro Millán, Ana María, additional, Peries Reverter, Laia, additional, Castro, Beatriz, additional, Fernández-Salgado, Estela, additional, Busto Cuiñas, M. Mercedes, additional, Benítez, José Manuel, additional, Madero, Lucía, additional, Clemente, Fernando, additional, Riestra, Sabino, additional, Jiménez-Treviño, Santiago, additional, Boscá-Watts, Maia, additional, Crehuá-Gaudiza, Elena, additional, Calvo Moya, Marta, additional, Huguet, José María, additional, Largo-Blanco, Ester-María, additional, González Vives, Leticia, additional, Plaza, Rocío, additional, Guerra, Iván, additional, Barrio, Josefa, additional, Escartín, Laura, additional, Alfambra, Erika, additional, Cruz, Noelia, additional, Muñoz, M. Carmen, additional, Muñoz Pino, María Guadalupe, additional, Van Domselaar, Manuel, additional, Botella, Belén, additional, Monfort Miquel, David, additional, Rodríguez Grau, M. Carmen, additional, De La Mano, Agustín, additional, Ber, Yolanda, additional, Calvo Iñiguez, María, additional, Martínez-Pérez, Teresa de Jesús, additional, Chaparro, María, additional, and Gisbert, Javier P., additional

Published
2023
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17. Cefalea en pacientes con enfermedad inflamatoria intestinal: prevalencia de migraña de acuerdo al Migraine Screening Questionnaire (MS-Q) y características de la cefalea

Author

González-Martínez, Alicia, primary, García, Inés Muro, additional, Quintas, Sonia, additional, Chaparro, María, additional, Gisbert, Javier P, additional, Sanz, Ancor, additional, Casanova, María José, additional, de Célix, Cristina Rubín, additional, Vivancos, José, additional, and Gago-Veiga, Ana Beatriz, additional

Published
2023
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19. Adalimumab or Infliximab for the Prevention of Early Postoperative Recurrence of Crohn Disease: Results From the ENEIDA Registry

Author

Cañete, Fiorella, Mañosa, Míriam, Casanova, María José, González-Sueyro, Ramiro C, Barrio, Jesús, Bermejo, Fernando, Nos, Pilar, Iglesias-Flores, Eva, García-Planella, Esther, Pérez-Calle, José Lázaro, Vicente, Raquel, Vera, Maribel, Ramos, Laura, Rivero, Montserrat, De Francisco, Ruth, Montserrat, Antonia, Benítez, Olga, Navarro, Pablo, Taxonera, Carlos, Hinojosa, Esther, Márquez-Mosquera, Lucía, Navarro-Llavat, Mercé, Ramírez-de la Piscina, Patricia, Gomollón, Fernando, Rodríguez-Alonso, Lorena, Núñez-Alonso, Alejandro, Fernández-Salazar, Luis, Almela, Pedro, Ríos León, Raquel, De Castro, Luisa, Gisbert, Javier P, Ricart, Elena, Cabré, Eduard, and Domènech, Eugeni

Published
2019
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20. Comparative Study of the Effectiveness of Vedolizumab Versus Ustekinumab After Anti-TNF Failure in Crohn's Disease (Versus-CD): Data from the ENEIDA Registry.

Author

García, María José, Rivero, Montserrat, Fernández-Clotet, Agnès, Francisco, Ruth de, Sicilia, Beatriz, Mesonero, Francisco, Castro, María Luisa de, Casanova, María José, Bertoletti, Federico, García-Alonso, Francisco Javier, López-García, Alicia, Vicente, Raquel, Calvet, Xavier, Acosta, Manuel Barreiro-de, Rosique, Juan Ferrer, Trastoy, Pilar Varela, Nuñez, Alejandro, Ricart, Elena, Riestra, Sabino, and García, Lara Arias

Abstract

Background Both vedolizumab and ustekinumab are approved for the management of Crohn's disease [CD]. Data on which one would be the most beneficial option when anti-tumour necrosis factor [anti-TNF] agents fail are limited. Aims To compare the durability, effectiveness, and safety of vedolizumab and ustekinumab after anti-TNF failure or intolerance in CD. Methods CD patients from the ENEIDA registry who received vedolizumab or ustekinumab after anti-TNF failure or intolerance were included. Durability and effectiveness were evaluated in both the short and the long term. Effectiveness was defined according to the Harvey–Bradshaw index [HBI]. The safety profile was compared between the two treatments. The propensity score was calculated by the inverse probability weighting method to balance confounder factors. Results A total of 835 patients from 30 centres were included, 207 treated with vedolizumab and 628 with ustekinumab. Dose intensification was performed in 295 patients. Vedolizumab [vs ustekinumab] was associated with a higher risk of treatment discontinuation (hazard ratio [HR] 2.55, 95% confidence interval [CI]: 2.02–3.21), adjusted by corticosteroids at baseline [HR 1.27; 95% CI: 1.00–1.62], moderate–severe activity in HBI [HR 1.79; 95% CI: 1.20–2.48], and high levels of C-reactive protein at baseline [HR 1.06; 95% CI: 1.02–1.10]. The inverse probability weighting method confirmed these results. Clinical response, remission, and corticosteroid-free clinical remission were higher with ustekinumab than with vedolizumab. Both drugs had a low risk of adverse events with no differences between them. Conclusion In CD patients who have failed anti-TNF agents, ustekinumab seems to be superior to vedolizumab in terms of durability and effectiveness in clinical practice. The safety profile is good and similar for both treatments. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Long Non-Coding RNA Signatures in the Ileum and Colon of Crohn's Disease Patients and Effect of Anti-TNF-α Treatment on Their Modulation.

Author

Baldan-Martin, Montse, Rubín de Célix, Cristina, Orejudo, Macarena, Ortega Moreno, Lorena, Fernández-Tomé, Samuel, Soleto, Irene, Ramirez, Cristina, Arroyo, Ricardo, Fernández, Paloma, Santander, Cecilio, Moreno-Monteagudo, José Andrés, Casanova, María José, Casals, Fernando, Casabona, Sergio, Becerro, Irene, Lozano, Juan J., Aransay, Ana M., Chaparro, María, and Gisbert, Javier P.

Subjects
CROHN'S disease, LINCRNA, ILEUM, GENE expression, COLON (Anatomy), INTESTINAL mucosa
Abstract

Biological therapies only benefit one-third of patients with Crohn's disease (CD). For this reason, a deeper understanding of the mechanisms by which biologics elicit their effect on intestinal mucosa is needed. Increasing evidence points toward the involvement of long noncoding RNAs (lncRNAs) in the pathogenesis of CD, although their role remains poorly studied. We aimed to characterize lncRNA profiles in the ileum and colon from CD patients and evaluate the effect of anti-TNF-α treatment on their transcription. Terminal ileum and left colon samples from 30 patients (active CD = 10, quiescent CD = 10, and healthy controls (HCs) = 10) were collected for RNA-seq. The patients were classified according to endoscopic activity. Furthermore, biopsies were cultured with infliximab, and their transcriptome was determined by Illumina gene expression array. A total of 678 differentially expressed lncRNAs between the terminal ileum and left colon were identified in HCs, 438 in patients with quiescent CD, and 468 in patients with active CD. Additionally, we identified three new lncRNAs in the ileum associated with CD activity. No differences were observed when comparing the effect of infliximab according to intestinal location, presence of disease (CD vs. HC), and activity (active vs. quiescent). The expression profiles of lncRNAs are associated with the location of intestinal tissue, being very different in the ileum and colon. The presence of CD and disease activity are associated with the differential expression of lncRNAs. No modulatory effect of infliximab has been observed in the lncRNA transcriptome. [ABSTRACT FROM AUTHOR]

Published
2023
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22. Real‐world outcomes of switching from adalimumab originator to adalimumab biosimilar in patients with inflammatory bowel disease: The ADA‐SWITCH study

Author

Casanova, María José, primary, Nantes, Óscar, additional, Varela, Pilar, additional, Vela‐González, Milagros, additional, Rivero, Montserrat, additional, Sierra‐Gabarda, Olivia, additional, Riestra, Sabino, additional, Acosta, Manuel Barreiro‐de, additional, del Mar Martín‐Rodríguez, María, additional, Gargallo‐Puyuelo, Carla Jerusalén, additional, Reygosa, Cristina, additional, Muñoz, Roser, additional, de la Filia‐Molina, Irene García, additional, Núñez‐Ortiz, Andrea, additional, Kolle, Lilyan, additional, Calafat, Margalida, additional, Huguet, José María, additional, Iglesias‐Flores, Eva, additional, Martínez‐Pérez, Teresa de Jesús, additional, Bosch, Orencio, additional, Duque‐Alcorta, José María, additional, Frago‐Larramona, Santiago, additional, Van Domselaar, Manuel, additional, González‐Cosano, Víctor Manuel, additional, Bujanda, Luis, additional, Rubio, Saioa, additional, Mancebo, Alejo, additional, Castro, Beatriz, additional, García‐López, Santiago, additional, de Francisco, Ruth, additional, Nieto‐García, Laura, additional, Laredo, Viviana, additional, Gutiérrez‐Casbas, Ana, additional, Mesonero, Francisco, additional, Leo‐Carnerero, Eduardo, additional, Cañete, Fiorella, additional, Ruiz, Lucía, additional, Gros, Beatriz, additional, del Moral‐Martínez, María, additional, Rodríguez, Cristina, additional, Chaparro, María, additional, and Gisbert, Javier P., additional

Published
2023
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23. EFICACIA Y SEGURIDAD DEL TRATAMIENTO DE RESCATE EN LA COLITIS ULCEROSA CORTICORREFRACTARIA GRAVE REFRACTARIA A INFLIXIMAB O CICLOSPORINA (ESTUDIO REASUC)

Author

García, María José, primary, Riestra, Sabino, additional, Amiot, Aurelien, additional, Julsgaard, Mette, additional, de la Filia, Irene García, additional, Calafat, Margalida, additional, Aguas, Mariam, additional, de la Peña, Luisa, additional, Roig-Ramos, Cristina, additional, Caballol, Berta, additional, Casanova, María José, additional, Farkas, Klaudia, additional, Boysen, Trine, additional, Bujanda, Luis, additional, Cuarán, Camila, additional, Dobru, Daniela, additional, Fousekis, Fotios, additional, Gargallo-Puyuelo, Carla Jerusalén, additional, Savarino, Edoardo, additional, Calvet, Xavier, additional, Huguet, José María, additional, Kupcinskas, Limas, additional, López-Cardona, Julia, additional, Raine, Tim, additional, van Oostrom, Joep, additional, Gisbert, Javier P., additional, and Chaparro, María, additional

Published
2023
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24. 46 - CARACTERÍSTICAS DE LA AFECTACIÓN ESOFAGOGASTRODUODENAL DE LA ENFERMEDAD DE CROHN EN LA ERA BIOLÓGICA: ESTUDIO MULTICÉNTRICO DEL GRUPO JOVEN DE GETECCU

Author

López-García, Alicia, primary, Benítez, José Manuel, additional, Maroto-Martín, Carlos, additional, Fernández-Prada, Samuel Juan, additional, Marquina, Victoria, additional, Rodríguez, Gloria Esther, additional, Mesonero, Francisco, additional, Lucendo, Alfredo J, additional, Flórez-Díez, Pablo, additional, Casanova, María José, additional, García-Morales, Natalia, additional, Miranda, José, additional, Vicuña, Miren, additional, Font, Guillem, additional, Suárez-Ferrer, Cristina, additional, Bernal, Lorena, additional, Peries, Laia, additional, Mínguez, Alejandro, additional, Tejedor, Javier, additional, Pérez-Galindo, Pablo, additional, Elosua, Alfonso, additional, Lastiri, Ernesto Alejandro, additional, Brunet, Eduard, additional, Llaó, Jordina, additional, Rodríguez-Lago, Iago, additional, Ferreiro-Iglesias, Rocío, additional, López, Laura, additional, González, Irene, additional, Ortega, Silvia Patricia, additional, Monsalve, Sara, additional, Márquez-Mosquera, Lucía, additional, González-Vivó, María, additional, Murciano, Francisca, additional, Zabana, Yamile, additional, and Acosta, Manuel Barreiro-de, additional

Published
2023
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25. 52 - PRESENTACIÓN CLÍNICA, MANEJO Y EVOLUCIÓN DE LOS LINFOMAS EN PACIENTES CON ENFERMEDAD INFLAMATORIA INTESTINAL: ESTUDIO NACIONAL BASADO EN EL REGISTRO ENEIDA

Author

Guerra, Iván, primary, Bujanda, Luis, additional, Mañosa, Miriam, additional, Martínez, Isabel Pérez, additional, Casanova, María José, additional, de la Peña, Luisa, additional, de Benito, Marina, additional, Rivero, Montserrat, additional, Varela, Pilar, additional, Bernal, Lorena, additional, Franco, Ana Carolina, additional, Ber, Yolanda, additional, Piqueras, Marta, additional, Tardillo, Carlos, additional, Ponferrada, Ángel, additional, Olivares, Sonsoles, additional, Lucendo, Alfredo J., additional, Gilabert, Pau, additional, Ausín, Mónica Sierra, additional, Bellart, María, additional, Herrarte, Amaia, additional, Calafat, Margalida, additional, de Francisco, Ruth, additional, Gisbert, Javier P., additional, Guardiola, Jordi, additional, Domènech, Eugeni, additional, and Bermejo, Fernando, additional

Published
2023
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26. 54 - CARACTERIZACIÓN DE LA MICROBIOTA FECAL EN PACIENTES CON ENFERMEDAD INFLAMATORIA INTESTINAL DE RECIENTE DIAGNÓSTICO MEDIANTE UN ABORDAJE METAGENÓMICO SHOTGUN

Author

del Río, Macarena Orejudo, primary, Baldán-Martín, Montse, additional, Soleto, Irene, additional, Ramirez, Cristina, additional, Mercado, Jorge, additional, Riestra, Sabino, additional, Rivero, Montserrat, additional, Gutiérrez, Ana, additional, Rodríguez-Lago, Iago, additional, Fernández, Luis, additional, Ceballos, Daniel, additional, Benítez, José Manuel, additional, Aguas, Mariam, additional, Bastón-Rey, Iria, additional, Bermejo, Fernando, additional, Casanova, María José, additional, Lorente, Rufo, additional, Ber, Yolanda, additional, Ginard, Daniel, additional, Esteve, María, additional, Gisbert, Javier P., additional, and Chaparro, María, additional

Published
2023
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27. 36 - EFECTIVIDAD Y SEGURIDAD DE LA TERAPIA CON USTEKINUMAB Y VEDOLIZUMAB EN PACIENTES CON FÍSTULA PERIANAL COMPLEJA: ESTUDIO HEAL

Author

Casanova, María José, primary, Chaparro, María, additional, Caballol, Berta, additional, García, María José, additional, Mesonero, Francisco, additional, de Célix, Cristina Rubín, additional, Suárez-álvarez, Patricia, additional, Ferreiro-Iglesias, Rocío, additional, del Mar Martín-Rodríguez, María, additional, de Francisco, Ruth, additional, Varela-Trastoy, Pilar, additional, Bastida, Guillermo, additional, Carrillo-Palau, Marta, additional, Núñez-Ortiz, Andrea, additional, Piscina, Patricia Ramírez-de la, additional, Ceballos, Daniel, additional, Hervías-Cruz, Daniel, additional, Muñoz-Pérez, Roser, additional, Velayos, Benito, additional, Bermejo, Fernando, additional, Busquets, David, additional, Cabacino, Manuel, additional, Camo-Monteverde, Patricia, additional, Marín-Jiménez, Ignacio, additional, Muñoz, Carmen, additional, de la Peña-Negro, Luisa Carmen, additional, Sierra-Moros, Eva, additional, Barrio, Jesús, additional, Brunet-Mas, Eduard, additional, Bujanda, Luis, additional, Cañete, Fiorella, additional, Gomollón, Fernando, additional, Manceñido-Marcos, Noemí, additional, Rodríguez-Lago, Iago, additional, Rodríguez-Grau, María Carmen, additional, Sicilia, Beatriz, additional, Torra-Alsina, Sandra, additional, Arranz-Hernández, Laura, additional, Carpio, Daniel, additional, García-Sepulcre, Mariana Fe, additional, González-Muñoza, Carlos, additional, Huguet, José María, additional, Márquez-Mosquera, Lucía, additional, López-Serrano, María Pilar, additional, Ponferrada-Díaz, Ángel, additional, and Gisbert, Javier P., additional

Published
2023
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28. 50 - IDENTIFICACIÓN DE BIOMARCADORES DIAGNÓSTICOS DE LA ENFERMEDAD INFLAMATORIA INTESTINAL EN SUERO Y ORINA MEDIANTE UN ABORDAJE PROTEÓMICO

Author

Baldán-Martín, Montse, primary, Azkargorta, Mikel, additional, Iloro, Ibon, additional, Soleto, Irene, additional, Orejudo, Macarena, additional, Ramirez, Cristina, additional, Mercado, Jorge, additional, Riestra, Sabino, additional, Rivero, Montserrat, additional, Gutiérrez, Ana, additional, Rodríguez-Lago, Iago, additional, Fernández-Salazar, Luis, additional, Ceballos, Daniel, additional, Benítez, José Manuel, additional, Aguas, Mariam, additional, Bastón-Rey, Iria, additional, Bermejo, Fernando, additional, Casanova, María José, additional, Lorente, Rufo, additional, Ber, Yolanda, additional, Royo, Vanesa, additional, Esteve, María, additional, Elortza, Félix, additional, Gisbert, Javier P., additional, and Chaparro, María, additional

Published
2023
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29. 34 - POSICIONAMIENTO DE LAS TERAPIAS DIRIGIDAS EN LA ENFERMEDAD INFLAMATORIA INTESTINAL (EII) EN VIDA REAL: ESTUDIO TRENDY DEL REGISTRO ENEIDA

Author

Gómez-Labrador, Celia, primary, Ricart, Elena, additional, Iborra, Marisa, additional, Iglesias, Eva, additional, Martín-Arranz, M. Dolores, additional, de Castro, Luisa, additional, de Francisco, Ruth, additional, García-Alonso, Francisco Javier, additional, Martínez, Ana Sanahuja, additional, Gargallo-Puyuelo, Carla J., additional, Mesonero, Francisco, additional, Casanova, María José, additional, Mañosa, Miriam, additional, Rivero, Montserrat, additional, Calvo, Marta, additional, Sierra-Ausin, Mónica, additional, González-Muñoza, Carlos, additional, Calvet, Xavier, additional, García-López, Santiago, additional, Guardiola, Jordi, additional, García, Lara Arias, additional, Márquez-Mosquera, Lucía, additional, Gutiérrez, Ana, additional, Zabana, Yamile, additional, Navarro, Merce, additional, Poyatos, Rufo Lorente, additional, Piqueras, Marta, additional, Torrealba, Leyanira, additional, Bermejo, Fernando, additional, Díaz, Ángel Ponferrada, additional, Pérez-Calle, José L, additional, Acosta, Manuel Barreiro-de, additional, Tejido, Coral, additional, Cabriada, José Luis, additional, Marín-Jiménez, Ignacio, additional, Roncero, Óscar, additional, Ber, Yolanda, additional, Fernández-Salazar, Luis, additional, Aler, Blau Camps, additional, Villarín, Alfredo J Lucendo, additional, Llaó, Jordina, additional, Bujanda, Luis, additional, Villafranca, Carmen Muñoz, additional, Domènech, Eugeni, additional, Chaparro, María, additional, and Gisbert, Javier P., additional

Published
2023
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30. 66 - EL ANÁLISIS DEL TEJIDO INTESTINAL DE PACIENTES RECIÉN DIAGNOSTICADOS DE ENFERMEDAD INFLAMATORIA INTESTINAL REVELA PERFILES PROTEÓMICOS ESPECÍFICOS

Author

Baldán-Martín, Montse, primary, Iloro, Ibon, additional, Azkargorta, Mikel, additional, Ramirez, Cristina, additional, Soleto, Irene, additional, Orejudo, Macarena, additional, Mercado, Jorge, additional, Gordillo, Carlos H., additional, Riestra, Sabino, additional, Rivero, Montserrat, additional, Gutiérrez, Ana, additional, Rodríguez-Lago, Iago, additional, Fernández-Salazar, Luis, additional, Ceballos, Daniel, additional, Benítez, José Manuel, additional, Aguas, Mariam, additional, Bastón-Rey, Iria, additional, Bermejo, Fernando, additional, Casanova, María José, additional, Lorente, Rufo, additional, Ber, Yolanda, additional, Royo, Vanesa, additional, Esteve, María, additional, Elortza, Félix, additional, Gisbert, Javier P., additional, and Chaparro, María, additional

Published
2023
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31. 62 - EFECTO EX VIVO DE INFLIXIMAB EN LOS NIVELES DE EXPRESIÓN DE LOS LONG NON-CODING RNAS EN LA ENFERMEDAD DE CROHN

Author

Baldán-Martín, Montse, primary, de Célix, Cristina Rubín, additional, Orejudo, Macarena, additional, Ortega, Lorena, additional, Tomé, Samuel Fernández, additional, Soleto, Irene, additional, Ramirez, Cristina, additional, Arroyo, Ricardo, additional, Fernández, Paloma, additional, Santander, Cecilio, additional, Moreno-Monteagudo, José Andrés, additional, Casanova, María José, additional, Casals, Fernando, additional, Casabona, Sergio, additional, Becerro, Irene, additional, Marigorta, Urko M., additional, Aransay, Ana M., additional, Bernardo, David, additional, Chaparro, María, additional, and Gisbert, Javier P., additional

Published
2023
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32. Clinical Presentation, Management, and Evolution of Lymphomas in Patients with Inflammatory Bowel Disease: An ENEIDA Registry Study

Author

Guerra, Ivan, Bujanda, Luis, Mañosa, Miriam, Pérez Martínez, Isabel, Casanova, María José, Peña, Luisa de la, Benito, Marina de, Rivero, Montserrat, Varela, Pilar, Bernal, Lorena, Franco, Ana Carolina, Ber, Yolanda, Piqueras, Marta, Tardillo, Carlos, Ponferrada, Ángel, Olivares, Sonsoles, Lucendo, Alfredo J., Gilabert, Pau, Sierra Ausín, Mónica, Bellart, María, Herrarte, Amaia, Calafat, Margalida, Francisco, Ruth de, Gisbert, Javier P., Guardiola, Jordi, Domènech, Eugeni, Bermejo, Fernando, and The ENEIDA project of GETECCU

Subjects
Cancer Research, Limfomes, Lymphoma, thiopurines, lymphoma, anti-TNF, Inflammatory bowel diseases, Inflammatory bowel disease, Malalties inflamatòries intestinals, Anti-TNF, Oncology, inflammatory bowel disease, Lymphomas, Thiopurines
Abstract

Simple Summary An increased risk of hematological malignancies, mainly lymphomas, has been described in patients with inflammatory bowel disease (IBD). Because there are scarce data about the management and evolution of lymphomas in patients with IBD, the aim of our study was to analyze these points in those patients with IBD and lymphoma diagnosis included in the prospectively maintained ENEIDA registry of GETECCU. We identified 52 patients (2.4 cases of lymphoma/1000 patients with IBD). We found that most IBD patients had been treated with thiopurines and/or anti-TNF agents before lymphoma diagnosis, and these patients were younger at diagnosis of lymphoma than those not treated with these drugs. Relapse and mortality of lymphoma were not related with these therapies. The five-year survival rate was 85% for non-Hodgkin lymphoma and 84% in patients with Hodgkin lymphoma. An increased risk of lymphoma has been described in patients with inflammatory bowel disease (IBD). The aims of our study were to determine the clinical presentation, the previous exposure to immunosuppressive and biologic therapies, and the evolution of lymphomas in patients with IBD. IBD patients with diagnosis of lymphoma from October 2006 to June 2021 were identified from the prospectively maintained ENEIDA registry of GETECCU. We identified 52 patients (2.4 cases of lymphoma/1000 patients with IBD; 95% CI 1.8-3.1). Thirty-five were men (67%), 52% had ulcerative colitis, 60% received thiopurines, and 38% an anti-TNF drug before lymphoma diagnosis. Age at lymphoma was lower in those patients treated with thiopurines (53 +/- 17 years old) and anti-TNF drugs (47 +/- 17) than in those patients not treated with these drugs (63 +/- 12; p < 0.05). Five cases had relapse of lymphoma (1.7 cases/100 patient-years). Nine patients (17%) died after 19 months (IQR 0-48 months). Relapse and mortality were not related with the type of IBD or lymphoma, nor with thiopurines or biologic therapies. In conclusion, most IBD patients had been treated with thiopurines and/or anti-TNF agents before lymphoma diagnosis, and these patients were younger at diagnosis of lymphoma than those not treated with these drugs. Relapse and mortality of lymphoma were not related with these therapies.

Published
2023
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33. 41 - BENEFICIO DE LOS PROGRAMAS DE TRANSICIÓN EN ENFERMEDAD INFLAMATORIA INTESTINAL: ESTUDIO BUTTERFLY DE GETECCU Y SEGHNP

Author

de Célix, Cristina Rubín, primary, Martín-de-Carpi, Javier, additional, Pujol-Muncunill, Gemma, additional, Palomino, Laura María, additional, Rodríguez-Belvís, Marta Velasco, additional, Martín-Masot, Rafael, additional, Navas-López, Víctor Manuel, additional, Ricart, Elena, additional, Casanova, María José, additional, Martínez, Alejandro Rodríguez, additional, Leo-Carnerero, Eduardo, additional, Alcaraz, Alba, additional, Mañosa, Miriam, additional, Hernández, Vicent, additional, Cobelas, María Consuelo Cobelas, additional, Sánchez, César, additional, Menchén, Luis, additional, Mesonero, Francisco, additional, Acosta, Manuel Barreiro-De, additional, Martínon, Nazareth, additional, Sandoval, Coral Tejido, additional, Vázquez, Alicia Rendo, additional, Corsino, Pilar, additional, Vicente, Raquel, additional, Hernández-Camba, Alejandro, additional, Alonso, José Ramón Alberto, additional, Alonso-Abreu, I., additional, Millán, Ana María Castro, additional, Reverter, Laia Peries, additional, Castro, Beatriz, additional, Fernández-Salgado, Estela, additional, Cuiñas, M Mercedes Busto, additional, Benítez, José Manuel, additional, Madero, Lucía, additional, Clemente, Fernando, additional, Riestra, Sabino, additional, Treviño, Santiago Jiménez-, additional, Boscá-Watts, Maia, additional, Crehuá-Gaudiza, Elena, additional, Moya, Marta Calvo, additional, Huguet, José María, additional, Largo-Blanco, Ester-María, additional, Vives, Leticia González, additional, Plaza, Rocío, additional, Guerra, Iván, additional, Barrio, Josefa, additional, Escartín, Laura, additional, Alfambra, Erika, additional, Cruz, Noelia, additional, Muñoz, M Carmen, additional, Pino, María Guadalupe Muñoz, additional, Van Domselaar, Manuel, additional, Botella, Belén, additional, Miquel, David Monfort, additional, Grau, M Carmen Rodríguez, additional, De La Mano, Agustín, additional, Ber, Yolanda, additional, Iñiguez, María Calvo, additional, de Jesús Martínez-Pérez, Teresa, additional, Chaparro, María, additional, and Gisbert, Javier P., additional

Published
2023
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34. Withdrawal of Anti-Tumour Necrosis Factor in Inflammatory Bowel Disease Patients in Remission: A Randomised Placebo-Controlled Clinical Trial of GETECCU

Author

Gisbert, Javier P., primary, García-Donday, María, additional, Riestra, Sabino, additional, Lucendo, Alfredo J., additional, Benítez, José Manuel, additional, Navarro-Llavat, Mercè, additional, Barrio, Jesús, additional, Morales-Alvarado, Víctor J., additional, Rivero, Montserrat, additional, Busquets, David, additional, Leo Carnerero, Eduardo, additional, Merino Ochoa, Olga, additional, Nantes Castillejo, Oscar, additional, Navarro, Pablo, additional, Van Domselaar, Manuel, additional, Gutiérrez Casbas, Ana, additional, Alonso-Abreu, Inmaculada, additional, Mejuto, Rafael, additional, Fernández Salazar, Luis, additional, Iborra, Marisa, additional, Martin-Arranz, Maria Dolores, additional, Pineda, Juan Ramón, additional, Sampedro, Manuela Josefa, additional, Serra Nilsson, katja, additional, Bouhmidi Assakali, Abdel, additional, Batista, Lissette, additional, Muñoz Villafranca, Carmen, additional, Rodríguez-Lago, Iago, additional, Ceballos Santos, Daniel Sebastián, additional, Guerra, Iván, additional, Mañosa, Miriam, additional, Marín Jiménez, Ignacio, additional, Torrella, Emilio, additional, Vera, Isabel, additional, Casanova, María José, additional, De Francisco, Ruth, additional, Arias-González, Laura, additional, Marín Pedrosa, Sandra, additional, García-Bosch, Orlando, additional, García-Alonso, Francisco Javier, additional, Delgado-Guillena, Pedro, additional, García, María José, additional, Torrealba, Leyanira, additional, Núñez-Ortiz, Andrea, additional, Vicuña Arregui, Miren, additional, Bosca-Watts, Marta Maia, additional, Blázquez, Isabel, additional, Acosta, Diana, additional, Garre, Ana, additional, Baldán, Montse, additional, Martínez, Concepción, additional, Barreiro-de Acosta, Manuel, additional, Domènech, Eugeni, additional, Esteve, Maria, additional, García-Sánchez, Valle, additional, Nos, Pilar, additional, Panés, Julian, additional, and Chaparro, Maria, additional

Published
2023
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35. ¿ES FACTIBLE LA SUSPENSIÓN DEL TRATAMIENTO ANTI-TNF EN PACIENTES CON ENFERMEDAD INFLAMATORIA INTESTINAL EN REMISIÓN SIN AUMENTAR EL RIESGO DE RECIDIVA? RESULTADOS DEL ENSAYO CLÍNICO ALEATORIZADO DE GETECCU (EXIT)

Author

Chaparro, María, primary, Donday, María García, additional, Riestra, Sabino, additional, Lucendo, Alfredo J, additional, Benítez, José Manuel, additional, Navarro-Llavat, Mercè, additional, Barrio, Jesús, additional, Morales-Alvarado, Víctor J., additional, Rivero, Montserrat, additional, Busquets, David, additional, Carnerero, Eduardo Leo, additional, Ochoa, Olga Merino, additional, Castillejo, Óscar Nantes, additional, Navarro, Pablo, additional, van Domselaar, Manuel, additional, Casbas, Ana Gutiérrez, additional, Alonso-Abreu, Inmaculada, additional, Mejuto, Rafael, additional, Salazar, Luis Fernández, additional, Iborra, Marisa, additional, Martín-Arranz, María Dolores, additional, Pineda, Juan Ramón, additional, Sampedro, Manuela Josefa, additional, Nilsson, Katja Serra, additional, Assakali, Abdel Bouhmidi, additional, Batista, Lissette, additional, Villafranca, Carmen Muñoz, additional, Rodríguez-Lago, Iago, additional, Santos, Daniel Sebastián Ceballos, additional, Guerra, Iván, additional, Mañosa, Miriam, additional, Jiménez, Ignacio Marín, additional, Torrella, Emilio, additional, Mendoza, Isabel Vera, additional, Casanova, María José, additional, de Francisco, Ruth, additional, Arias-González, Laura, additional, Pedrosa, Sandra Marín, additional, García-Bosch, Orlando, additional, García-Alonso, Francisco Javier, additional, Guillena, Pedro Delgado-, additional, García, María José, additional, Torrealba, Leyanira, additional, Núñez-Ortiz, Andrea, additional, Arregui, Miren Vicuña, additional, Bosca-Watts, Marta Maia, additional, Blázquez, Isabel, additional, Acosta, Diana, additional, Garre, Ana, additional, Martínez, Concepción, additional, Acosta, Manuel Barreiro-de, additional, Domènech, Eugeni, additional, Esteve, María, additional, García-Sánchez, Valle, additional, Nos, Pilar, additional, Panés, Julian, additional, and Gisbert, Javier P., additional

Published
2023
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36. SEGURIDAD DE LAS VACUNAS DE VIRUS VIVOS EN NIÑOS EXPUESTOS A FÁRMACOS BIOLÓGICOS PARA LA ENFERMEDAD INFLAMATORIA INTESTINAL (EII) EN EL ÚTERO O DURANTE LA LACTANCIA MATERNA

Author

Chaparro, María, primary, Donday, María García, additional, Rubio, Saioa, additional, Suarez, Cristina Calviño, additional, Ortiz, Andrea Núñez, additional, Figueira, Montserrat, additional, Pedrosa, Sandra Marín, additional, Rivero, Montserrat, additional, Fernández-Clotet, Agnes, additional, Madero, Lucía, additional, Palomares, María Teresa Diz-Lois, additional, Pérez-Martínez, Isabel, additional, Ruiz-Cerulla, Alexandra, additional, Arroyo, Maite, additional, Piqueras, Marta, additional, Ferrer, Cristina Suárez, additional, Aguas, Mariam, additional, Moya, Marta Calvo, additional, Guerra, Iván, additional, Serrano, Pilar López, additional, Morón, Juan María Vázquez, additional, García, Lara Arias, additional, Casanova, María José, additional, Huguet, José María, additional, Gomis, Gemma Valldosera, additional, de Mora-Figueroa, Beatriz Zúñiga, additional, Armesto, Rubén, additional, Montiel, Pilar Martínez, additional, Rodríguez-Lago, Iago, additional, Rumbeu, Pau Sendra, additional, Camero, Raquel Camargo, additional, Cruz, Daniel Hervías, additional, Arriero, Gema Molina, additional, Marín, Carlos Tardillo, additional, de Jorge Turrión, Miguel Ángel, additional, Lidón, Raquel Vicente, additional, Bujanda, Luis, additional, de la Piscina, Patricia Ramírez, additional, Alonso, Virginia Robles, additional, Ramos, Laura, additional, Insa, Raúl Rodríguez, additional, van Domselaar, Manuel, additional, Casals, David Busquets, additional, Marcos, Noemí Manceñido, additional, Grau, María Carmen Rodríguez, additional, González, Edisa María Armesto, additional, Lucendo, Alfredo J, additional, Márquez-Mosquera, Lucía, additional, López, Víctor Manuel Navas, additional, Prieto, Vanessa, additional, Nieto, Yolanda Ber, additional, Martín, Esther Bernardos, additional, Milla, Carlos Castaño, additional, Hernández, Luis, additional, Arnau, Empar Sáinz, additional, Sans, Miquel, additional, Martínez, Belén Herreros, additional, Morales, Víctor Jair, additional, Mínguez, Miguel, additional, Acosta, Manuel Barreiro-de, additional, Acosta, Diana, additional, Brenes, Yanire, additional, Hermida, Sandra, additional, Parra, Pablo, additional, Garre, Ana, additional, and Gisbert, Javier P., additional

Published
2023
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37. Differential Effects of Anti-TNFα and Anti-α4β7 Drugs on Circulating Dendritic Cells Migratory Capacity in Inflammatory Bowel Disease

Author

Soleto, Irene, primary, Fernández-Tomé, Samuel, additional, Mora-Gutiérrez, Irene, additional, Baldan-Martin, Montserrat, additional, Ramírez, Cristina, additional, Santander, Cecilio, additional, Moreno-Monteagudo, José Andrés, additional, Casanova, María José, additional, Casals, Fernando, additional, Casabona, Sergio, additional, Becerro, Irene, additional, Chaparro, María, additional, Bernardo, David, additional, and Gisbert, Javier P., additional

Published
2022
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38. Prevalence of Malnutrition and Nutritional Characteristics of Patients With Inflammatory Bowel Disease

Author

Casanova, María José, Chaparro, Maria, Molina, Begoña, Merino, Olga, Batanero, Ricardo, Dueñas-Sadornil, Carmen, Robledo, Pilar, Garcia-Albert, Ana María, Gómez-Sánchez, Maria Bienvenida, Calvet, Xavier, Trallero, Maria del Roser, Montoro, Miguel, Vázquez, Iria, Charro, Mara, Barragán, Amaya, Martínez-Cerezo, Francisco, Megias-Rangil, Isabel, Huguet, José María, Marti-Bonmati, Ezequiel, Calvo, Marta, Campderá, Mariana, Muñoz-Vicente, Margarita, Merchante, Angel, Ávila, Ansel David, Serrano-Aguayo, Pilar, De Francisco, Ruth, Hervías, Daniel, Bujanda, Luis, Rodriguez, Gloria Esther, Castro-Laria, Luisa, Barreiro-de Acosta, Manuel, Van Domselaar, Manuel, Ramirez de la Piscina, Patricia, Santos-Fernández, Javier, Algaba, Alicia, Torra, Sandra, Pozzati, Liliana, López-Serrano, Pilar, Arribas, Maria del Rosario, Rincón, Maria Luisa, Peláez, Andrés Camilo, Castro, Elena, García-Herola, Antonio, Santander, Cecilio, Hernández-Alonso, Moisés, Martín-Noguerol, Elisa, Gómez-Lozano, María, Monedero, Tamara, Villoria, Albert, Figuerola, Ariadna, Castaño-García, Andrés, Banales, Jesús M, Díaz-Hernández, Laura, Argüelles-Arias, Federico, López-Díaz, Javier, Pérez-Martínez, Isabel, García-Talavera, Noelia, Nuevo-Siguairo, Olivia Karina, Riestra, Sabino, and Gisbert, Javier P

Published
2017
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39. Long-Term Outcomes of Biological Therapy in Crohn’s Disease Complicated With Internal Fistulizing Disease: BIOSCOPE Study From GETECCU.

Author

Barreiro-de Acosta, Manuel, Fernández-Clotet, Agnès, Mesonero, Francisco, García-Alonso, Francisco Javier, Casanova, María José, Fernández-de la Varga, Margarita, Cañete, Fiorella, de Castro, Luisa, Gutiérrez, Ana, Sicilia, Beatriz, Cano, Victoria, Merino, Olga, de Francisco, Ruth, González-Partida, Irene, Surís, Gerard, Torrealba, Leyanira, Ferreiro-Iglesias, Rocío, Castro, Beatriz, Márquez, Lucía, and Sobrino, Ana

Published
2023
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40. Correction: Chaparro et al. Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain: Large-Scale Epidemiological Study. J. Clin. Med. 2021, 10, 2885

Author

Chaparro, María, Garre, Ana, Núñez Ortiz, Andrea, Diz-Lois Palomares, María Teresa, Rodríguez, Cristina, Riestra, Sabino, Vela, Milagros, Benítez, José Manuel, Fernández Salgado, Estela, Sánchez Rodríguez, Eugenia, Hernández, Vicent, Ferreiro-Iglesias, Rocío, Ponferrada Díaz, Ángel, Barrio, Jesús, Huguet, José María, Sicilia, Beatriz, Martín-Arranz, María Dolores, Calvet, Xavier, Ginard, Daniel, Alonso-Abreu, Inmaculada, Fernández-Salazar, Luis, Varela Trastoy, Pilar, Rivero, Montserrat, Vera-Mendoza, Isabel, Vega, Pablo, Navarro, Pablo, Sierra, Mónica, Cabriada, José Luis, Aguas, Mariam, Vicente, Raquel, Navarro-Llavat, Mercè, Echarri, Ana, Gomollón, Fernando, Guerra Del Río, Elena, Piñero, Concepción, Casanova, María José, Spicakova, Katerina, Ortiz de Zarate, Jone, Torrella Cortés, Emilio, Gutiérrez, Ana, Alonso-Galán, Horacio, Hernández-Martínez, Álvaro, Marrero, José Miguel, Lorente Poyatos, Rufo, Calafat, Margalida, Martí Romero, Lidia, Robledo, Pilar, Bosch, Orencio, Jiménez, Nuria, Esteve Comas, María, Duque, José María, Fuentes Coronel, Ana María, Josefa Sampedro, Manuela, Sesé Abizanda, Eva, Herreros Martínez, Belén, Pozzati, Liliana, Fernández Rosáenz, Hipólito, Crespo Suarez, Belén, López Serrano, Pilar, Lucendo, Alfredo J, Muñoz Vicente, Margarita, Bermejo, Fernando, Ramírez Palanca, José Joaquín, Menacho, Margarita, Carmona, Amalia, Camargo, Raquel, Torra Alsina, Sandra, Maroto, Nuria, Nerín de la Puerta, Juan, Castro, Elena, Marín-Jiménez, Ignacio, Botella, Belén, Sapiña, Amparo, Cruz, Noelia, Forcelledo, José Luis F, Bouhmidi, Abdel, Castaño-Milla, Carlos, Opio, Verónica, Nicolás, Isabel, Kutz, Marcos, Abraldes Bechiarelli, Alfredo, Gordillo, Jordi, Ber, Yolanda, Torres Domínguez, Yolanda, Novella Durán, María Teresa, Rodríguez Mondéjar, Silvia, Martínez-Cerezo, Francisco J, Kolle, Lilyan, Sabat, Miriam, Ledezma, Cesar, Iyo, Eduardo, Roncero, Óscar, Irisarri, Rebeca, Lluis, Laia, Blázquez Gómez, Isabel, Zapata, Eva María, José Alcalá, María, Martínez Pascual, Cristina, Montealegre, María, Mata, Laura, Monrobel, Ana, Hernández Camba, Alejandro, Hernández, Luis, Tejada, María, Mir, Alberto, Galve, María Luisa, Soler, Marta, Hervías, Daniel, Gómez-Valero, José Antonio, Barreiro-de Acosta, Manuel, Rodríguez-Artalejo, Fernando, García-Esquinas, Esther, Gisbert, Javier P, and On Behalf Of The EpidemIBD Study Group Of Geteccu

Subjects
General Medicine
Abstract

The authors wish to make the following corrections to this paper [...]

Published
2022

41. Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain: Large-Scale Epidemiological Study

Author

Chaparro, María, Garre, Ana, Núñez Ortiz, Andrea, Diz-Lois Palomares, María Teresa, Rodríguez, Cristina, Riestra, Sabino, Vela, Milagros, Benítez, José Manuel, Fernández Salgado, Estela, Sánchez Rodríguez, Eugenia, Hernández, Vicent, Ferreiro-Iglesias, Rocío, Ponferrada Díaz, Ángel, Barrio, Jesús, Huguet, José María, Sicilia, Beatriz, Martín-Arranz, María Dolores, Calvet, Xavier, Ginard, Daniel, Alonso-Abreu, Inmaculada, Fernández-Salazar, Luis, Varela Trastoy, Pilar, Rivero, Montserrat, Vera-Mendoza, Isabel, Vega, Pablo, Navarro, Pablo, Sierra, Mónica, Cabriada, José Luis, Aguas, Mariam, Vicente, Raquel, Navarro-Llavat, Mercè, Echarri, Ana, Gomollón, Fernando, Guerra Del Río, Elena, Piñero, Concepción, Casanova, María José, Spicakova, Katerina, Ortiz de Zarate, Jone, Torrella Cortés, Emilio, Gutiérrez, Ana, Alonso-Galán, Horacio, Hernández-Martínez, Álvaro, Marrero, José Miguel, Lorente Poyatos, Rufo, Calafat, Margalida, Martí Romero, Lidia, Robledo, Pilar, Bosch, Orencio, Jiménez, Nuria, Esteve Comas, María, Duque, José María, Fuentes Coronel, Ana María, Josefa Sampedro, Manuela, Sesé Abizanda, Eva, Herreros Martínez, Belén, Pozzati, Liliana, Fernández Rosáenz, Hipólito, Crespo Suarez, Belén, López Serrano, Pilar, Lucendo, Alfredo J, Muñoz Vicente, Margarita, Bermejo, Fernando, Ramírez Palanca, José Joaquín, Menacho, Margarita, Carmona, Amalia, Camargo, Raquel, Torra Alsina, Sandra, Maroto, Nuria, Nerín de la Puerta, Juan, Castro, Elena, Marín-Jiménez, Ignacio, Botella, Belén, Sapiña, Amparo, Cruz, Noelia, Forcelledo, José Luis F, Bouhmidi, Abdel, Castaño-Milla, Carlos, Opio, Verónica, Nicolás, Isabel, Kutz, Marcos, Abraldes Bechiarelli, Alfredo, Gordillo, Jordi, Ber, Yolanda, Torres Domínguez, Yolanda, Novella Durán, María Teresa, Rodríguez Mondéjar, Silvia, Martínez-Cerezo, Francisco J, Kolle, Lilyan, Sabat, Miriam, Ledezma, Cesar, Iyo, Eduardo, Roncero, Óscar, Irisarri, Rebeca, Lluis, Laia, Blázquez Gómez, Isabel, Zapata, Eva María, José Alcalá, María, Martínez Pascual, Cristina, Montealegre, María, Mata, Laura, Monrobel, Ana, Hernández Camba, Alejandro, Hernández, Luis, Tejada, María, Mir, Alberto, Galve, María Luisa, Soler, Marta, Hervías, Daniel, Gómez-Valero, José Antonio, Barreiro-de Acosta, Manuel, Rodríguez-Artalejo, Fernando, García-Esquinas, Esther, Gisbert, Javier P, On Behalf Of The EpidemIBD Study Group Of Geteccu, and Servicio de Digestivo. Hospital Universitario de Fuenlabrada

Subjects
Crohn’s disease, medicine.medical_specialty, Population, Disease, Inflammatory bowel disease, digestive system, Article, 03 medical and health sciences, 0302 clinical medicine, Interquartile range, inflammatory bowel disease, Internal medicine, Epidemiology, Medicine, education, Crohn’s disease, epidemiology, incidence, inflammatory bowel disease, ulcerative colitis, ulcerative colitis, Crohn's disease, education.field_of_study, business.industry, Incidence (epidemiology), General Medicine, medicine.disease, Ulcerative colitis, digestive system diseases, 030220 oncology & carcinogenesis, incidence, 030211 gastroenterology & hepatology, epidemiology, business
Abstract

(1) Aims: To assess the incidence of inflammatory bowel disease (IBD) in Spain, to describe the main epidemiological and clinical characteristics at diagnosis and the evolution of the disease, and to explore the use of drug treatments. (2) Methods: Prospective, population-based nationwide registry. Adult patients diagnosed with IBD—Crohn’s disease (CD), ulcerative colitis (UC) or IBD unclassified (IBD-U)—during 2017 in Spain were included and were followed-up for 1 year. (3) Results: We identified 3611 incident cases of IBD diagnosed during 2017 in 108 hospitals covering over 22 million inhabitants. The overall incidence (cases/100,000 person-years) was 16 for IBD, 7.5 for CD, 8 for UC, and 0.5 for IBD-U, 53% of patients were male and median age was 43 years (interquartile range = 31–56 years). During a median 12-month follow-up, 34% of patients were treated with systemic steroids, 25% with immunomodulators, 15% with biologics and 5.6% underwent surgery. The percentage of patients under these treatments was significantly higher in CD than UC and IBD-U. Use of systemic steroids and biologics was significantly higher in hospitals with high resources. In total, 28% of patients were hospitalized (35% CD and 22% UC patients, p &lt, 0.01). (4) Conclusion: The incidence of IBD in Spain is rather high and similar to that reported in Northern Europe. IBD patients require substantial therapeutic resources, which are greater in CD and in hospitals with high resources, and much higher than previously reported. One third of patients are hospitalized in the first year after diagnosis and a relevant proportion undergo surgery.

Published
2021

43. Early treatment with anti-tumor necrosis factor agents improves long-term effectiveness in symptomatic stricturing Crohn's disease

Author

Rodríguez-Lago, Iago, Hoyo, Javier Del, Pérez-Girbés, Alexandre, Garrido-Marín, Alejandro, Casanova, María José, Chaparro, María, Fernández-Clotet, Agnès, Castro-Poceiro, Jesús, García, María José, Sánchez, Sara, Ferreiro-Iglesias, Rocío, Bastón, Iria, Piqueras, Marta, Careda, Lola Esteba I Bech de, Mena, Raquel, Suárez, Cristina, Cordón, Joaquín Poza, López-García, Alicia, Márquez, Lucía, Arroyo, Maite, Alfambra, Erika, Sierra, Mónica, Cano, Noelia, Delgado-Guillena, Pedro, Morales-Alvarado, Víctor, Aparicio, Juan Carlos, Guerra, Iván, Aulló, Carolina, Merino, Olga, Arranz, Laura, Hidalgo, María Araceli, Llaó, Jordina, Plaza, Rocío, Molina, Gema, Torres, Paola, Pérez-Galindo, Pablo, Romero, María Giselle, Herrera-deGuise, Claudia, Armesto, Edisa, Mesonero, Francisco, Frago-Larramona, Santiago, Benítez, José Manuel, Calvo, Marta, Martín, María Del Carmen López, Elorza, Ainara, Larena, Alejandro, Peña, Elena, Rodríguez-Grau, María Del Carmen, Miguel-Criado, Jaime de, Botella, Belén, Olmos, José Antonio, López, Laura, Aguirre, Urko, Gisbert, Javier P, and Young GETECCU Group

Subjects
Crohn’s disease, stricture, Adult, Male, medicine.medical_specialty, Anti-TNF, Crohn’s disease, biologic drug, stricture, surgery, Constriction, Pathologic, Gastroenterology, Endoscopy, Gastrointestinal, Time-to-Treatment, Anti-TNF, surgery, 03 medical and health sciences, Biological Factors, Young Adult, 0302 clinical medicine, Patient Admission, Postoperative Complications, Crohn Disease, Risk Factors, Internal medicine, medicine, Anti tumor necrosis factor, Humans, In patient, Limited evidence, Retrospective Studies, Crohn's disease, business.industry, Tumor Necrosis Factor-alpha, Adalimumab, Age Factors, Original Articles, Middle Aged, medicine.disease, digestive system diseases, Infliximab, Intestines, Treatment Outcome, Oncology, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Female, business, biologic drug, Follow-Up Studies
Abstract

BACKGROUND: There is limited evidence on the effectiveness of biological therapy in stricturing complications in patients with Crohn’s disease. AIM: The study aims to determine the effectiveness of anti-tumor necrosis factor (TNF) agents in Crohn’s disease complicated with symptomatic strictures. METHODS: In this multicentric and retrospective study, we included adult patients with symptomatic stricturing Crohn’s disease receiving their first anti-TNF therapy, with no previous history of biological, endoscopic or surgical therapy. The effectiveness of the anti-TNF agent was defined as a composite outcome combining steroid-free drug persistence with no use of new biologics or immunomodulators, hospital admission, surgery or endoscopic therapy during follow-up. RESULTS: Overall, 262 patients with Crohn’s disease were included (53% male; median disease duration, 35 months, 15% active smokers), who received either infliximab (N = 141, 54%) or adalimumab (N = 121, 46%). The treatment was effective in 87% and 73% of patients after 6 and 12 months, respectively, and continued to be effective in 26% after a median follow-up of 40 months (IQR, 19–85). Nonetheless, 15% and 21% of individuals required surgery after 1 and 2 years, respectively, with an overall surgery rate of 32%. Postoperative complications were identified in 15% of patients, with surgical site infection as the most common. Starting anti-TNF therapy in the first 18 months after the diagnosis of Crohn’s disease or the identification of stricturing complications was associated with a higher effectiveness (HR 1.62, 95% CI 1.18–2.22; and HR 1.55, 95% CI 1.1–2.23; respectively). Younger age, lower albumin levels, strictures located in the descending colon, concomitant aminosalicylates use or presence of lymphadenopathy were associated with lower effectiveness. CONCLUSIONS: Anti-TNF agents are effective in approximately a quarter of patients with Crohn’s disease and symptomatic intestinal strictures, and 68% of patients are free of surgery after a median of 40 months of follow-up. Early treatment and some potential predictors of response were associated with treatment success in this setting.

Published
2020
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44. Effectiveness and Safety of Ustekinumab in Ulcerative Colitis: Real-world Evidence from the ENEIDA Registry

Author

Chaparro, María, primary, Garre, Ana, additional, Iborra, Marisa, additional, Sierra-Ausín, Mónica, additional, Barreiro-de Acosta, Manuel, additional, Fernández-Clotet, Agnès, additional, de Castro, Luisa, additional, Boscá-Watts, Maia, additional, Casanova, María José, additional, López-García, Alicia, additional, Lorente, Rufo, additional, Rodríguez, Cristina, additional, Carbajo, Ana Y, additional, Arroyo, Maria Teresa, additional, Gutiérrez, Ana, additional, Hinojosa, Joaquín, additional, Martínez-Pérez, Teresa, additional, Villoria, Albert, additional, Bermejo, Fernando, additional, Busquets, David, additional, Camps, Blau, additional, Cañete, Fiorella, additional, Manceñido, Noemí, additional, Monfort, David, additional, Navarro-Llavat, Mercè, additional, Pérez-Calle, José Lázaro, additional, Ramos, Laura, additional, Rivero, Montserrat, additional, Angueira, Teresa, additional, Camo Monterde, Patricia, additional, Carpio, Daniel, additional, García-de-la-Filia, Irene, additional, González-Muñoza, Carlos, additional, Hernández, Luis, additional, Huguet, José M, additional, Morales, Víctor J, additional, Sicilia, Beatriz, additional, Vega, Pablo, additional, Vera, Isabel, additional, Zabana, Yamile, additional, Nos, Pilar, additional, Suárez Álvarez, Patricia, additional, Calviño-Suárez, Cristina, additional, Ricart, Elena, additional, Hernández, Vicent, additional, Mínguez, Miguel, additional, Márquez, Lucía, additional, Hervías Cruz, Daniel, additional, Rubio Iturria, Saioa, additional, Barrio, Jesús, additional, Gargallo-Puyuelo, Carla, additional, Francés, Rubén, additional, Hinojosa, Esther, additional, del Moral, María, additional, Calvet, Xavier, additional, Algaba, Alicia, additional, Aldeguer, Xavier, additional, Guardiola, Jordi, additional, Mañosa, Miriam, additional, Pajares, Ramón, additional, Piqueras, Marta, additional, García-Bosch, Orlando, additional, López Serrano, Pilar, additional, Castro, Beatriz, additional, Lucendo, Alfredo J, additional, Montoro, Miguel, additional, Castro Ortiz, Elena, additional, Mesonero, Francisco, additional, García-Planella, Esther, additional, Fuentes, David A, additional, Bort, Inmaculada, additional, Delgado-Guillena, Pedro, additional, Arias, Lara, additional, Iglesias, Agueda, additional, Calvo, Marta, additional, Esteve, Maria, additional, Domènech, Eugeni, additional, and Gisbert, Javier P, additional

Published
2021
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45. CARACTERIZACIÓN PROTEÓMICA DE LAS VESÍCULAS EXTRACELULARES SÉRICAS DE PACIENTES RECIÉN DIAGNOSTICADOS DE ENFERMEDAD INFLAMATORIA INTESTINAL

Author

Soleto, Irene, Baldan-Martín, Montse, Ramirez, Cristina, Orejudo, Macarena, García, Sara, Mercado, Jorge, Azkargorta, Mikel, Iloro, Ibon, Moreno, Lorena Ortega, Garcia, Laila Aldars, Riestra, Sabino, Rivero, Montserrat, Gutierrez, Ana, Rodríguez-Lago, Iago, Fernández, Luis, Ceballos, Daniel, Benitez, Jose Manuel, Aguas, Mariam, Rey, Iria Bastón, Bermejo, Fernando, Casanova, Maria Jose, Llorente, Rufo, Ber, Yolanda, Ginard, Daniel, Esteve, Maria, Elortza, Felix, Gisbert, Javier P, Martín-Cofreces, Noa, and Chaparro, Maria

Published
2023
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46. Poor Sensitivity of Fecal Gluten Immunogenic Peptides and Serum Antibodies to Detect Duodenal Mucosal Damage in Celiac Disease Monitoring

Author

Laserna-Mendieta, Emilio J., primary, Casanova, María José, additional, Arias, Ángel, additional, Arias-González, Laura, additional, Majano, Pedro, additional, Mate, Luis Alberto, additional, Gordillo-Vélez, Carlos Humberto, additional, Jiménez, Mirella, additional, Angueira, Teresa, additional, Tébar-Romero, Emilia, additional, Carrillo-Ramos, María Jesús, additional, Tejero-Bustos, María Ángeles, additional, Gisbert, Javier P., additional, Santander, Cecilio, additional, and Lucendo, Alfredo J., additional

Published
2020
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47. Tofacitinib in Ulcerative Colitis: Real-world Evidence From the ENEIDA Registry

Author

Chaparro, María, primary, Garre, Ana, additional, Mesonero, Francisco, additional, Rodríguez, Cristina, additional, Barreiro-de Acosta, Manuel, additional, Martínez-Cadilla, Jesús, additional, Arroyo, María T, additional, Manceñido, Noemí, additional, Sierra-Ausín, Mónica, additional, Vera-Mendoza, Isabel, additional, Casanova, María José, additional, Nos, Pilar, additional, González-Muñoza, Carlos, additional, Martínez, Teresa, additional, Boscá-Watts, Maia, additional, Calafat, Margalida, additional, Busquets, David, additional, Girona, Eva, additional, Llaó, Jordina, additional, Martín-Arranz, María Dolores, additional, Piqueras, Marta, additional, Ramos, Laura, additional, Surís, Gerard, additional, Bermejo, Fernando, additional, Carbajo, Ana Y, additional, Casas-Deza, Diego, additional, Fernández-Clotet, Agnes, additional, García, María J, additional, Ginard, Daniel, additional, Gutiérrez-Casbas, Ana, additional, Hernández, Luis, additional, Lucendo, Alfredo J, additional, Márquez, Lucía, additional, Merino-Ochoa, Olga, additional, Rancel, Francisco J, additional, Taxonera, Carlos, additional, López Sanromán, Antonio, additional, Rubio, Saioa, additional, Domènech, Eugeni, additional, and Gisbert, Javier P, additional

Published
2020
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48. Antitumor Necrosis Factor Agents to Treat EndoscopicPostoperative Recurrence of Crohn’s Disease: A Nationwide Study With Propensity-Matched Score Analysis

Author

Medicina, Medikuntza, Cañete, Fiorella, Mañosa, Míriam, Pérez Martínez, Isabel, Barreiro de Acosta, Manuel, González Sueyro, Ramiro C., Nos, Pilar, Iglesias Flores, Eva, Gutiérrez, Ana, Bujanda Fernández de Pierola, Luis, Gordillo, Jordi, Ríos León, Raquel, Casanova, María José, Villoria, Albert, Rodríguez Lago, Iago, López Serrano, Pilar, García Herola, Antonio, Ramírez de la Piscina, Patricia, Navarro Llavat, Mercè, Taxonera, Carlos, Barrio, Jesús, Ramos, Laura, Navarro, Pablo, Benítez Leiva, Olga, Calafat, Margalida, Domènech, Eugeni, INFLIRECU study, Medicina, Medikuntza, Cañete, Fiorella, Mañosa, Míriam, Pérez Martínez, Isabel, Barreiro de Acosta, Manuel, González Sueyro, Ramiro C., Nos, Pilar, Iglesias Flores, Eva, Gutiérrez, Ana, Bujanda Fernández de Pierola, Luis, Gordillo, Jordi, Ríos León, Raquel, Casanova, María José, Villoria, Albert, Rodríguez Lago, Iago, López Serrano, Pilar, García Herola, Antonio, Ramírez de la Piscina, Patricia, Navarro Llavat, Mercè, Taxonera, Carlos, Barrio, Jesús, Ramos, Laura, Navarro, Pablo, Benítez Leiva, Olga, Calafat, Margalida, Domènech, Eugeni, and INFLIRECU study

Abstract

INTRODUCTION:Patients with Crohn's disease experiencing endoscopic postoperative recurrence (POR) may benefit from antitumor necrosis factor (TNF) agents but scarce data on this are available. Our aim was to assess the efficacy of anti-TNF in improving mucosal lesions in patients with endoscopic POR.METHODS:Multicenter, retrospective, study of patients with Crohn's disease who underwent therapy with anti-TNF agents for endoscopic POR (Rutgeerts score > i1). Treatment outcomes were assessed by the findings in the last ileocolonoscopy performed after anti-TNF therapy was initiated. Endoscopic improvement and remission were defined as any reduction in the baseline Rutgeerts score and by a Rutgeerts score < i2, respectively.RESULTS:A total of 179 patients were included, 83 were treated with infliximab and 96 with adalimumab. Median time on anti-TNF therapy at the last endoscopic assessment was 31 months (interquartile range, 13-54). Endoscopic improvement was observed in 61%, including 42% who achieved endoscopic remission. Concomitant use of thiopurines and treatment with infliximab were associated with endoscopic improvement (odds ratio [OR] 2.15, 95% confidence interval [CI] 1.04-4.46; P = 0.03, and OR 2.34, 95% CI 1.18-4.62; P < 0.01, respectively) and endoscopic remission (OR 3.16, 95% CI 1.65-6.05; P < 0.01, and OR 2.01, 95% CI 1.05-3.88; P = 0.04, respectively) in the multivariable logistic regression analysis. These results were confirmed in a propensity-matched score analysis.DISCUSSION:In patients with endoscopic POR, anti-TNF agents improve mucosal lesions in almost two-thirds of the patients. In this setting, concomitant use of thiopurines and use of infliximab seem to be more effective in improving mucosal lesions.

Published
2020

49. Su1501: PROPHYLACTIC VERSUS ENDOSCOPY DRIVEN TREATMENT OF CROHN'S POSTOPERATIVE RECURRENCE: A RETROSPECTIVE MULTICENTRIC EUROPEAN STUDY

Author

Geldof, Jeroen, Truyens, Marie, Hanssens, Michiel, Holvoet, Tom, Ainara, Elorza, Bouillon, Vincent, Barros, Sónia, Argyriou, Konstantinos, Diculescu, Mircea, Moens, Annick, Theodoraki, Eirini, Serrazina, Juliana, Nikolaou, Pinelopi, Baert, Filip J., Ferreiro, Rocio, Peeters, Harald, Casanova, Mariá José, Eder, Piotr, Porter, Ross J., Karakan, Tarkan, Mesonero, Francisco, Revés, Joana, Evi, Van Dyck, Jauregui-Amezaga, Aranzazu, Mañosa, Miriam, Rivière, Pauline, Mosquera, Lucia Marquez, Portela, Francisco, and Lobaton, Triana

Published
2022
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50. Clinical features, therapeutic requirements and evolution of patients with Crohn's disease and upper gastrointestinal involvement (CROHNEX study).

Author

Sainz, Empar, Zabana, Yamile, Miguel, Isabel, Fernández‐Clotet, Agnès, Beltrán, Belén, Núñez, Laura, García, María José, Martín‐Arranz, María Dolores, Iglesias, Eva, Cañete, Fiorella, Gutiérrez, Ana, Piqueras, Marta, Pérez‐Martínez, Isabel, Bujanda, Luis, Rodríguez‐Lago, Iago, Casanova, María José, Navarro, Pablo, Vicente, Raquel, Merino, Olga, and Algaba, Alicia

Subjects
IRON deficiency anemia, GASTROINTESTINAL diseases, CROHN'S disease, THERAPEUTIC complications
Abstract

Summary: Background: Crohn's disease (CD) with upper gastrointestinal involvement (UGI) may have a more aggressive and refractory course. However, evidence on this phenotype of patients is scarce. Aims: To identify the clinical characteristics, therapeutic requirements and complications associated with UGI in CD Methods: Nationwide study of cases (UGI, UGI plus ileal/ileocolonic involvement) paired with controls (ileal/ileocolonic involvement) from the ENEIDA registry. Cases were matched to 2 controls by year of diagnosis ± 2.5 years. Patients with exclusive/predominant colonic location or complex perianal fistula were excluded. Results: Of 24 738 patients with CD in the ENEIDA registry, we identified 4058 with UGI (16% of the total CD cohort). Finally, 854 cases and 1708 controls were included. Cases were independently associated to extensive involvement (OR 2.7 [2.2‐3.3], P < 0.0001), strictures [OR 1.8 (1.5‐2.2), P < 0.0001], chronic iron deficiency anaemia [OR 2.2 (1.3‐3.2), P < 0.001] and use of second‐line biologics [OR 1.7 (1.1‐2.6), P = 0.021]. The median stricture‐free time was 14 years (95% CI, 12‐16) for cases vs 21 years (95% CI, 19‐23) for controls (P < 0.0001). Cases with isolated UGI compared to UGI plus ileal/ileocolonic more frequently had localised disease [OR 0.5(0.3‐0.8), P = 0.003] and underwent more endoscopic stricture dilations [OR 2.7(1.3‐5.4), P = 0.006]. Conclusions: The largest cohort of patients with CD and UGI provides information on the natural history of this particular phenotype. Increased awareness of the clinical picture and therapeutic requirements of these patients could lead to earlier diagnosis and treatment of upper gastrointestinal lesions, preventing the structural damage frequently seen in these patients at diagnosis and during follow‐up. [ABSTRACT FROM AUTHOR]

Published
2021
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