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2. Associations of Alcohol Consumption With Left Atrial Morphology and Function in a Population at High Cardiovascular Risk

Author

Bioquímica i Biotecnologia, Universitat Rovira i Virgili, Alam AB; Toledo-Atucha E; Romaguera D; Alonso-Gómez AM; Martínez-Gonzalez MA; Tojal-Sierra L; Mora MN; Mas-Llado C; Li L; Gonzalez-Casanova I; Salas-Salvadó J; Fitó M; Alonso A, Bioquímica i Biotecnologia, Universitat Rovira i Virgili, and Alam AB; Toledo-Atucha E; Romaguera D; Alonso-Gómez AM; Martínez-Gonzalez MA; Tojal-Sierra L; Mora MN; Mas-Llado C; Li L; Gonzalez-Casanova I; Salas-Salvadó J; Fitó M; Alonso A

Abstract

Excessive alcohol consumption has been associated with increased risk of atrial fibrillation, although the underlying mechanisms remain unclear. An enlarged left atrium and impaired left atrial function may lead to atrial fibrillation. The association of alcohol consumption with structural and functional left atrial measures, however, has received limited attention.We studied 503 participants from the PREDIMED-Plus (Prevención con Dieta Mediterránea) trial, a randomized trial testing intensive weight loss intervention with an energy-reduced Mediterranean diet and physical activity promotion in preventing cardiovascular disease in adults with metabolic syndrome. Participants underwent transthoracic echocardiography at baseline, year 3, and year 5 of the study. Outcomes of interest included volume index and reservoir, conduit, and contractile strains of the left atrium. Alcohol consumption was calculated through food frequency questionnaires and presented as drinks consumed per day. Multiple linear regression and mixed models estimated the association of alcohol consumption with left atrial measurements at baseline and through follow-up. Cross-sectionally, higher alcohol consumption (per 1 drink/day increases) was associated with larger left atrial volume (0.65 mL/m2 [95% CI, 0.18-1.11]) and lower left atrial reservoir and contractile strain (-0.44% [95% CI, -0.87 to -0.01]; and -0.44% [95% CI, -0.75 to -0.14]). Baseline alcohol consumption was not associated with changes in left atrial measurements, but increases in alcohol consumption (per 1 drink/day increase) during follow-up were associated with left atrial enlargement (0.71 mL/m2 [95% CI, 0.17-1.26]).In a population at high cardiovascular risk, increased alcohol consumption was associated with left atrial enlargemen

Published
2024

3. Specific Cytotoxic Effect of an Auristatin Nanoconjugate Towards CXCR4+ Diffuse Large B-Cell Lymphoma Cells

Author

Falgàs A, Pallarès V, Unzueta U, Núñez Y, Sierra J, Gallardo A, Alba-Castellón L, Mangues MA, Álamo P, Villaverde A, Vázquez E, Mangues R, and Casanova I

Subjects
nanomedicine, targeted drug delivery, mmae, dlbcl, Medicine (General), R5-920
Abstract

Aïda Falgàs,1– 3 Victor Pallarès,1– 3 Ugutz Unzueta,1– 4 Yáiza Núñez,1,2 Jorge Sierra,2,5 Alberto Gallardo,1 Lorena Alba-Castellón,1,2 Maria Antonia Mangues,3,6 Patricia Álamo,1– 3 Antonio Villaverde,3,4,7 Esther Vázquez,3,4,7 Ramon Mangues,1– 3 Isolda Casanova1– 3 1Biomedical Research Institute Sant Pau (IIB-Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, 08025, Spain; 2Josep Carreras Leukaemia Research Institute (IJC), Barcelona, 08916, Spain; 3CIBER de Bioingeniería Biomateriales y Nanomedicina (CIBER-BBN), Madrid, 28029, Spain; 4Department of Genetics and Microbiology, Universitat Autònoma de Barcelona, Barcelona, 08193, Spain; 5Department of Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona, 08025, Spain; 6Department of Pharmacy, Hospital de la Santa Creu i Sant Pau, Barcelona, 08025, Spain; 7Institute of Biotechnology and Biomedicine (IBB), Universitat Autònoma de Barcelona, Barcelona, 08193, SpainCorrespondence: Esther VázquezInstitute of Biotechnology and Biomedicine (IBB) and Department of Genetics and Microbiology, Universitat Autònoma de Barcelona and CIBER-BBN, Barcelona, SpainTel +34 935812148Email Esther.Vazquez@uab.esRamon ManguesBiomedical Research Institute Sant Pau (IIB-Sant Pau), Josep Carreras Leukaemia Research Institute (IJC) and CIBER-BBN, Barcelona, SpainTel +34 935537918Email RMangues@santpau.catBackground and Purpose: Around 40– 50% of diffuse large-B cell lymphoma (DLBCL) patients suffer from refractory disease or relapse after R-CHOP first-line treatment. Many ongoing clinical trials for DLBCL patients involve microtubule targeting agents (MTAs), however, their anticancer activity is limited by severe side effects. Therefore, we chose to improve the therapeutic window of the MTA monomethyl auristatin E developing a nanoconjugate, T22-AUR, that selectively targets the CXCR4 receptor, which is overexpressed in many DLBCL cells (CXCR4+) and associated with poor prognosis.Methods: The T22-AUR specificity towards CXCR4 receptor was performed by flow cytometry in different DLBCL cell lines and running biodistribution assays in a subcutaneous mouse model bearing CXCR4+ DLBCL cells. Moreover, we determined T22-AUR cytotoxicity using cell viability assays, cell cycle analysis, DAPI staining and immunohistochemistry. Finally, the T22-AUR antineoplastic effect was evaluated in vivo in an extranodal CXCR4+ DLBCL mouse model whereas the toxicity analysis was assessed by histopathology in non-infiltrated mouse organs and by in vitro cytotoxic assays in human PBMCs.Results: We demonstrate that the T22-AUR nanoconjugate displays CXCR4-dependent targeting and internalization in CXCR4+ DLBCL cells in vitro as well as in a subcutaneous DLBCL mouse model. Moreover, it shows high cytotoxic effect in CXCR4+ DLBCL cells, including induction of G2/M mitotic arrest, DNA damage, mitotic catastrophe and apoptosis. Furthermore, the nanoconjugate shows a potent reduction in lymphoma mouse dissemination without histopathological alterations in non-DLBCL infiltrated organs. Importantly, T22-AUR also exhibits lack of toxicity in human PBMCs.Conclusion: T22-AUR exerts in vitro and in vivo anticancer effect on CXCR4+ DLBCL cells without off-target toxicity. Thus, T22-AUR promises to become an effective therapy for CXCR4+ DLBCL patients.Keywords: nanomedicine, targeted drug delivery, MMAE, DLBCL

Published
2021

5. Analysis of cubic and orthorhombic C3A hydration in presence of gypsum and lime

Author

Kirchheim, A. P., Fernàndez-Altable, V., Monteiro, P. J., Dal Molin, D. C., and Casanova, I.

Subjects
Material Science, Mechanics, Crystallography, Continuum Mechanics and Mechanics of Materials, Polymer Sciences, Characterization and Evaluation of Materials, Materials Science, general
Abstract

Field emission scanning electron microscopy (FE-SEM) and X-ray diffraction (XRD) have been used to study the microstructural changes and phase development that take place during the hydration of cubic (pure) and orthorhombic (Na-doped) tricalcium aluminate (C3A) and gypsum in the absence and presence of lime. The results demonstrate that important differences occur in the hydration of each C3A polymorph and gypsum when no lime is added; orthorhombic C3A reacts faster with gypsum than the cubic phase, forming longer ettringite needles; however, the presence of lime slows down the formation of ettringite in the orthorhombic sample. Additional rheometric tests showed the possible effects on the setting time in these cementitious mixes.

Published
2009

6. Towards a better future for biodiversity and people: Modelling Nature Futures

Author

Kim, H., Peterson, G., Cheung, W., Ferrier, S., Alkemade, R., Arneth, A., Kuiper, J., Okayasu, S., Pereira, L., Acosta, L., Chaplin-Kramer, R., den Belder, E., Eddy, T., Johnson, J., Karlsson-Vinkhuyzen, S., Kok, M., Leadley, P., Leclere, D., Lundquist, C., Rondinini, C., Scholes, R., Schoolenberg, M., Shin, Y.-J., Stehfest, E., Stephenson, F., Visconti, P., van Vuuren, D., Wabnitz, C., José Alava, J., Cuadros-Casanova, I., Davies, K., Gasalla, M., Halouani, G., Harfoot, M., Hashimoto, S., Hickler, T., Hirsch, T., Kolomytsev, G., Miller, B., Ohashi, H., Gabriela Palomo, M., Popp, A., Paco Remme, R., Saito, O., Rashid Sumalia, U., Willcock, S., Pereira, H., Kim, H., Peterson, G., Cheung, W., Ferrier, S., Alkemade, R., Arneth, A., Kuiper, J., Okayasu, S., Pereira, L., Acosta, L., Chaplin-Kramer, R., den Belder, E., Eddy, T., Johnson, J., Karlsson-Vinkhuyzen, S., Kok, M., Leadley, P., Leclere, D., Lundquist, C., Rondinini, C., Scholes, R., Schoolenberg, M., Shin, Y.-J., Stehfest, E., Stephenson, F., Visconti, P., van Vuuren, D., Wabnitz, C., José Alava, J., Cuadros-Casanova, I., Davies, K., Gasalla, M., Halouani, G., Harfoot, M., Hashimoto, S., Hickler, T., Hirsch, T., Kolomytsev, G., Miller, B., Ohashi, H., Gabriela Palomo, M., Popp, A., Paco Remme, R., Saito, O., Rashid Sumalia, U., Willcock, S., and Pereira, H.

Abstract

The Nature Futures Framework (NFF) is a heuristic tool for co-creating positive futures for nature and people. It seeks to open up a diversity of futures through mainly three value perspectives on nature – Nature for Nature, Nature for Society, and Nature as Culture. This paper describes how the NFF can be applied in modelling to support decision-making. First, we describe key considerations for the NFF in developing qualitative and quantitative scenarios: i) multiple value perspectives on nature as a state space where pathways improving nature toward a frontier can be represented, ii) mutually reinforcing key feedbacks of social-ecological systems that are important for nature conservation and human wellbeing, iii) indicators of multiple knowledge systems describing the evolution of complex social-ecological dynamics. We then present three approaches to modelling Nature Futures scenarios in the review, screening, and design phases of policy processes. This paper seeks to facilitate the integration of relational values of nature in models and strengthen modelled linkages across biodiversity, nature’s contributions to people, and quality of life.

Published
2023
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8. Aulamar: Projecte escola d’oceanografia costanera

Author

Carrasco Serra, Oriol, Castells Sanabra, Marcel·la, Barberan, V, Bardaji, Raul, Gelardo, N, Gonzalez, O., Hoareau, N, Mateu, J, Ortigosa, I, Puigdefabregas, J, Simon, C, Vallès-Casanova, I, and Pelegrí, Josep Lluís

Subjects
Patí científic, Recursos generals [Àrees temàtiques de la UPC], Patí a Vela, Sail boats, Vida submarina, Plàstics, Clima, Climatic changes, Velers, Microplàstics, Canvis climàtics
Abstract

En aquest Research Café es presenten projectes on la tecnologia es posa al servei dels mars i els oceans, i que estan lligats amb els objectius ODS Vida Submarina i Acció pel clima. Objectius de Desenvolupament Sostenible::13 - Acció per al Clima Objectius de Desenvolupament Sostenible::14 - Vida Submarina

Published
2022

10. Multicausal etiology of anemia among women of reproductive age in Vietnam

Author

Nguyen, P.H., Gonzalez-Casanova, I., Nguyen, H., Pham, H., Truong, T.V., Nguyen, S., Martorell, R., and Ramakrishnan, U.

Subjects
Women -- Health aspects, Medical research, Medicine, Experimental, Anemia -- Physiological aspects, Food/cooking/nutrition, Health
Abstract

BACKGROUND/OBJECTIVES: Anemia is a significant public health concern, especially among women and young children. An improved understanding of the complex etiology of anemia is crucial for developing appropriate prevention strategies. This paper examines the determinants of anemia in a large sample of Vietnamese women of reproductive age (WRA). METHODS: We included baseline data from 4986 WRA participating in a randomized controlled trial (PRECONCEPT). Hemoglobin (Hb) concentrations were measured with Hemocue. Plasma ferritin (Fe), retinol binding protein (RBP) and markers of inflammation were assessed using the ELISA technique. We used multivariate logistic regression to describe associations with anemia and structural equation modeling (SEM) to characterize direct and indirect pathways influencing Hb concentrations. RESULTS: Prevalence of anemia, iron deficiency (Fe < 12 µg/l), insufficient iron stores (Fe < 30 µg/l) and iron deficiency anemia was 19.7, 3.5, 14.4 and 1.9%, respectively. Ferritin concentration (0.29 per log-mg/dl), being an ethnic minority (-0.24 compared with Kinh), number of children (-0.17) and socioeconomic status (0.09) were directly associated with Hb concentration (P < 0.05). Similarly, RBP was directly (0.27 per mg/dl) associated with Hb and also indirectly (0.09 mg/dl) with ferritin. Hookworm infection was indirectly associated with Hb (-0.11) through RBP and ferritin. CONCLUSION: These findings illustrate the complex etiology of anemia and provide a useful framework for designing, targeting and evaluating appropriate strategies for the prevention and control of anemia. Contrary to expectations, iron deficiency accounted for a very small proportion of anemia in Northern Vietnam. European Journal of Clinical Nutrition (2015) 69, 107-113; doi: 10.1038/ejcn.2014.181; published online 10 September 2014, INTRODUCTION Anemia is a major public health concern worldwide, especially among women and children. Globally, anemia affects 24.8% of the population; the highest prevalence is among preschool-aged children (47.4%), followed [...]

Published
2015
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12. P436: TARGETED DELIVERY OF T22-PE24-H6 TO CXCR4 POSITIVE CELLS FOR ACUTE MYELOID LEUKEMIA TREATMENT

Author

Núñez Amela, Y., primary, Garcia-León, A., additional, Falgàs, A., additional, Serna, N., additional, Sánchez-García, L., additional, Garrido, A., additional, Sierra, J., additional, Gallardo, A., additional, Unzueta, U., additional, Vázquez, E., additional, Villaverde, A., additional, Mangues, R., additional, and Casanova, I., additional

Published
2022
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13. Self-assembling protein nanocarrier for selective delivery of cytotoxic polypeptides to CXCR4+ head and neck squamous cell carcinoma tumors

Author

Rioja-Blanco E., Arroyo-Solera I., Álamo P., Casanova I., Gallardo A., Unzueta U., Serna N., Sánchez-García L., Quer M., Villaverde A., Vázquez E., Mangues R., Alba-Castellón L., and León X.

Subjects
Protein nanoparticles, Recombinant proteins, Targeted drug delivery, Cell targeting, Cancer therapy, CXCR4 receptor, Nanotoxins, HNSCC
Abstract

Loco-regional recurrences and distant metastases represent the main cause of head and neck squamous cell carcinoma (HNSCC) mortality. The overexpression of chemokine receptor 4 (CXCR4) in HNSCC primary tumors associates with higher risk of developing loco-regional recurrences and distant metastases, thus making CXCR4 an ideal entry pathway for targeted drug delivery. In this context, our group has generated the self-assembling protein nanocarrier T22-GFP-H6, displaying multiple T22 peptidic ligands that specifically target CXCR4. This study aimed to validate T22-GFP-H6 as a suitable nanocarrier to selectively deliver cytotoxic agents to CXCR4+ tumors in a HNSCC model. Here we demonstrate that T22-GFP-H6 selectively internalizes in CXCR4+ HNSCC cells, achieving a high accumulation in CXCR4+ tumors in vivo, while showing negligible nanocarrier distribution in non-tumor bearing organs. Moreover, this T22-empowered nanocarrier can incorporate bacterial toxin domains to generate therapeutic nanotoxins that induce cell death in CXCR4-overexpressing tumors in the absence of histological alterations in normal organs. Altogether, these results show the potential use of this T22-empowered nanocarrier platform to incorporate polypeptidic domains of choice to selectively eliminate CXCR4+ cells in HNSCC. Remarkably, to our knowledge, this is the first study testing targeted protein-only nanoparticles in this cancer type, which may represent a novel treatment approach for HNSCC patients. © 2022 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences

Published
2022

14. The role of connectivity on COVID-19 preventive approaches

Author

András Tóbiás, Etienne Nzabarushimana, Nava-Trejo Je, Gonzalez-Casanova I, Gonzalez-Casanova A, and Miro Pina

Subjects
2019-20 coronavirus outbreak, Power law degree distribution, Coronavirus disease 2019 (COVID-19), Population, Public health interventions, Virus testing, Psychological intervention, MEDLINE, Article, Pandemic, Humans, Random variables, education, Pandemics, Preventive medicine, education.field_of_study, Vaccines, Multidisciplinary, Public economics, Vaccination, Immunity, COVID-19, Communicable Disease Control, Vaccination and immunization, Public Health, Psychology, Graphs, COVID 19
Abstract

Preventive and modelling approaches to address the COVID-19 pandemic have been primarily based on the age or occupation, and often disregard the importance of heterogeneity in population contact structure and individual connectivity. To address this gap, we developed models based on Erdős-Rényi and a power law degree distribution that first incorporate the role of heterogeneity and connectivity and then can be expanded to make assumptions about demographic characteristics. Results demonstrate that variations in the number of connections of individuals within a population modify the impact of public health interventions such as lockdown or vaccination approaches. We conclude that the most effective strategy will vary depending on the underlying contact structure of individuals within a population and on timing of the interventions.Author summaryThe best strategy for public health interventions, such as lockdown or vaccination, depends on the contact structure of the population and the timing of the intervention. In general, for heterogeneous contact structures that mimic the COVID-19 spread, which is characterized by the presence of super spreaders, vaccinating the most connected individuals first was the most effective strategy to prevent infections and deaths, especially when coupled to serological tests. Models considering heterogeneity in human interactions need be used to identify the best potential vaccine prioritization strategies.

Published
2022

15. Intracellular CXCR4+ cell targeting with T22-empowered protein-only nanoparticles

Author

Unzueta U, Céspedes MV, Ferrer-Miralles N, Casanova I, Cedano J, Corchero JL, Domingo-Espín J, Villaverde A, Mangues R, and Vázquez E

Subjects
Medicine (General), R5-920
Abstract

Ugutz Unzueta,1–3 María Virtudes Céspedes,3,4 Neus Ferrer-Miralles,1–3 Isolda Casanova,3,4 Juan Cedano,5 José Luis Corchero,1–3 Joan Domingo-Espín,1–3 Antonio Villaverde,1–3 Ramón Mangues,3,4 Esther Vázquez1–31Institut de Biotecnologia i de Biomedicina, 2Departamento de Genètica i de Microbiologia, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, 3CIBER en Bioingeniería, Biomateriales y Nanomedicina, Bellaterra, Barcelona, 4Oncogenesis and Antitumor Drug Group, Biomedical Research Institute Sant Pau, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; 5Laboratory of Immunology, Regional Norte, Universidad de la Republica, Salto, UruguayBackground: Cell-targeting peptides or proteins are appealing tools in nanomedicine and innovative medicines because they increase the local drug concentration and reduce potential side effects. CXC chemokine receptor 4 (CXCR4) is a cell surface marker associated with several severe human pathologies, including colorectal cancer, for which intracellular targeting agents are currently missing.Results: Four different peptides that bind CXCR4 were tested for their ability to internalize a green fluorescent protein-based reporter nanoparticle into CXCR4+ cells. Among them, only the 18 mer peptide T22, an engineered segment derivative of polyphemusin II from the horseshoe crab, efficiently penetrated target cells via a rapid, receptor-specific endosomal route. This resulted in accumulation of the reporter nanoparticle in a fully fluorescent and stable form in the perinuclear region of the target cells, without toxicity either in cell culture or in an in vivo model of metastatic colorectal cancer.Conclusion: Given the urgent demand for targeting agents in the research, diagnosis, and treatment of CXCR4-linked diseases, including colorectal cancer and human immunodeficiency virus infection, T22 appears to be a promising tag for the intracellular delivery of protein drugs, nanoparticles, and imaging agents.Keywords: peptide tag, CXCR4, intracellular targeting, self-assembling, nanoparticles, colorectal cancer

Published
2012

20. Post-anaesthesia pulmonary complications after use of muscle relaxants (POPULAR): a multicentre, prospective observational study

Author

Kirmeier, E, Eriksson, L, Lewald, H, Jonsson Fagerlund, M, Hoeft, A, Hollmann, M, Meistelman, C, Hunter, J, Ulm, K, Blobner, M, Abad Gurumeta, A, Abernethy, C, Abigail, P, Achaibar, K, Adam, E, Afshari, A, Agudelo Montoya, M, Akgun, F, Aletti, G, Alkis, N, Allan, K, Allan, A, Allaouchiche, B, Allcock, C, Almasy, E, Amey, I, Amigoni, M, Andersen, E, Andersson, P, Anipchenko, N, Antunes, P, Armstrong, E, Aslam, T, Aslin, B, Assuncao, J, Ausserer, J, Avvai, M, Awad, N, Ayas Montero, B, Ayuso, M, Azevedo, P, Badarau, V, Badescu, R, Baiardo Redaelli, M, Baird, C, Baird, Y, Baker, T, Balaji, P, Balan, C, Balandin, A, Balescu-Arion, C, Baliuliene, V, Baltasar Isabel, J, Baluch, S, Bandrabur, D, Bankewitz, C, Barber, K, Barbera, F, Barcraft-Barnes, H, Barletti, V, Barnett, G, Baron, K, Barros, A, Barsan, V, Bartlett, P, Batistaki, C, Baumgarten, G, Baytas, V, Beauchamp, N, Becerra Cayetano, I, Bell, S, Bellandi, M, Belletti, A, Belmonte Cuenca, J, Benitez-Cano, A, Beretta, L, Berger, M, Bergmann, N, Bergmark, K, Bermudez Lopez, M, Bernotaite, M, Beurskens, C, Bidd, H, Bifulco, F, Bignami, E, Bilic, A, Bilskiene, D, Bischoff, P, Bishop, L, Bjonness, T, Blaylock, H, Blethyn, K, Blincoe, T, Blokhin, I, Blunt, N, Boer, C, Bois, G, Bonicolini, E, Booth, J, Borecka-Kedzierska, M, Borstnar, K, Borys, M, Boselli, E, Bouvet, L, Bouwman, A, Bowen, L, Bowrey, S, Boxall, L, Bozic, T, Bradley, T, Branco, T, Brazzi, L, Brazzoni, M, Brear, T, Brogly, N, Brohi, F, Broms, J, Bubliauskas, A, Bucolo, G, Buerkle, H, Buggy, D, Buhre, W, Bukauskas, T, Butturini, F, Byttner, A, Cabrera Diaz, I, Calderon, A, Calhau, R, Callejo, A, Cammu, G, Campesato, M, Can, O, Candeias, M, Cantor, A, Carise, E, Carmona, C, Carreteiro, J, Carrieri, C, Carter, A, Casal, M, Casanova, I, Cascella, M, Casero, L, Casiraghi, G, Castelo-Branco, L, Castro Arranz, C, Cernea, D, Cervantes, J, Chandler, B, Charnock, R, Chatzimicali, A, Chinery, E, Chishti, A, Chondhury, P, Christie, E, Christodoudiles, G, Ciardo, S, Cimpeanu, L, Cindea, I, Cinnella, G, Clark, S, Clayton, M, Cocu, S, Collyer, T, Colvin, C, Cope, S, Copeta, F, Copotoiu, S, Correia de Barros, F, Corso, R, Cortegiani, A, Costa, G, Cowton, A, Cox, N, Craig, J, Cricca, V, Cronin, J, Cunha, M, Cuomo, A, Curley, K, Czuczwar, M, Dabrowska, D, Damster, S, Danguy des Deserts, M, Daniliuc, A, Danninger, T, Darwish, I, Dascalu, C, Davies, K, Davies, S, De Boer, H, De Flaviis, A, De Selincourt, G, Deana, C, Debaene, B, Debreceni, G, Dedhia, J, Delgado Garcia, I, Della Rocca, G, Delroy-Buelles, L, Desai, T, Dhillon, P, Di Giacinto, I, Di Mauro, P, Diaz Gomez, T, Dimitrovski, A, Dinic, V, Dirzu, D, Divander, M, Dolinar, J, Domingues, S, Doolan, J, Downes, C, Dragoescu, N, Droc, G, Dum, E, Dumitrescu, A, Duncan, L, Dzurnakova, P, Eberl, S, Edwards, J, Edwards, M, Ekelund, K, Ekengren, P, Elghouty, E, Ellerkmann, R, Ellis, H, Elme, A, Ernst, T, Errando, C, Estenes, S, Ewaldsson, C, Farid, N, Featherstone, J, Febres, D, Fedorov, S, Feggeler, J, Feijten, P, Fellmann, T, Fernandez Candil, J, Fernandez Castineira, A, Fernandez Castineira, J, Fernando, A, Ferrando, C, Ferreira, L, Ferreira, P, Feyling, A, Filipescu, D, Fleischer, A, Floris, L, Foerster, U, Fox, B, Franke, U, Frasca, D, Frey, C, Frost, V, Fullin, G, Fumagalli, J, Furneval, J, Fusari, M, Gallacher, S, Galushka, S, Gambale, G, Gambino, I, Garcia-Perez, M, Garg, S, Garlak, J, Gavranovic, Z, Gavrilov, R, Gaynor, L, Gecaj Gashi, A, Georghiou, M, Gerjevic, B, Gferer, G, Giarratano, A, Gibson, A, Gievski, V, Giles, J, Gillberg, L, Gilowska, K, Gilsanz Rodriguez, F, Gioia, A, Giovannoni, C, Girotra, V, Gkinas, D, Gkiokas, G, Godoroja, D, Goebel, U, Goel, V, Gonzalez, M, Goranovic, T, Gornik-Wlaszczuk, E, Gosavi, S, Gottfridsson, P, Gottschalk, A, Granell, M, Granstrom, A, Grassetto, A, Greenwood, A, Grigoras, I, Grintescu, I, Gritsan, A, Gritsan, G, Grynyuk, A, Guadagnin, G, Guarnieri, M, Guclu, C, Guerrero Diez, M, Gunenc, F, Gunther, U, Gupta, P, Guttenthaler, V, Hack, Y, Hafisayena, A, Hagau, N, Haldar, J, Hales, D, Hanci, V, Hanna-Jumma, S, Harazim, H, Harlet, P, Harper, D, Harris, B, Harvey, O, Hashimi, M, Hawkins, L, Hayes, C, Heaton, J, Heier, T, Helliwell, L, Hemmes, S, Henderson, K, Hermanides, J, Hermanns, H, Herrera Hueso, B, Hestenes, S, Hettiarachchi, R, Highgate, J, Hodgson, K, Hoelbling, D, Holland, J, Horhota, L, Hormis, A, Hribar, R, Hua, A, Humphreys, S, Humphries, R, Humplikova, S, Hunt, J, Husnain, A, Hussein, A, Hyams, B, Iannuccelli, F, Ilette, K, Ilyas, C, Inan, T, India, I, Ionitav, V, Irwin, F, Jain, V, Janez, B, Jankovic, R, Jenkins, S, Jenko, M, Jimenez, R, Jimenez Gomez, B, Joachim, S, Joelsson-Alm, E, John, J, Jonikaite, L, Jovic, M, Jungwirth, B, Junke, E, Kabakov, B, Kadaoui, S, Kanski, A, Karadag, S, Karbonskiene, A, Karjagin, J, Kasnik, D, Katanolli, F, Katsika, E, Kaufmann, K, Keane, H, Kelly, M, Kent, M, Keraitiene, G, Khudhur, A, Khuenl-Brady, K, Kidd, L, King, S, Kirchgassner, K, Klancir, T, Klucniks, A, Knotzer, J, Knowlden, P, Koers, L, Kompan, J, Koneti, K, Kooij, F, Koolen, E, Koopman - van Gemert, A, Kopp, K, Korfiotis, D, Korolkov, O, Kosinova, M, Kostenberger, M, Kotzinger, O, Kovacevic, M, Kranke, P, Kranke, E, Kraus, C, Kraus, S, Kubitzek, C, Kucharski, R, Kucukguclu, S, Kudrashou, A, Kumar, V, Kummen, L, Kunit, C, Kushakovsky, V, Kuvaki, B, Kuzmanovska, B, Kyttari, A, Landoni, G, Lau, G, Lazarev, K, Legett, S, Legrottaglie, A, Leonardi, S, Leong, M, Lercher, H, Leuvrey, M, Leva, B, Levstek, M, Limb, J, Lindholm, E, Linton, F, Liperi, C, Lipski, F, Lirk, P, Lisi, A, Liskova, K, Lluch Oltra, A, Loganathan, V, Lombardi, S, Lopez, E, Lopez Rodriguez, M, Lorenzini, L, Lowicka, M, Lugovoy, A, Luippold, M, Lumb, A, Macas, A, Macgregor, M, Machado, H, Maciariello, M, Madeira, I, Maitan, S, Majewski, J, Maldini, B, Malewski, G, Manfredini, L, Manner, O, Marchand, B, Marcu, A, Margalef, J, Margarson, M, Marinheiro, L, Markic, A, Markovic Bozic, J, Marrazzo, F, Martin, J, Martin Ayuso, M, Martinez, E, Martino, E, Martinson, V, Marusic-Gaser, K, Mascarenhas, C, Mathis, C, Matsota, P, Mavrommati, E, Mazul Sunko, B, Mccourt, K, Mcgill, N, Mckee, R, Meco, B, Meier, S, Melbourne, S, Melbybrathen, G, Meli, A, Melia, A, Melotti, R, Menga, M, Mercer, P, Merotra, S, Mescolini, S, Metterlein, T, Michalov, M, Michlig, S, Midgley, S, Milic, M, Milojevic, M, Minana, A, Minto, G, Mirabella, L, Mirea, L, Mittelstadt, L, Moeglen, A, Moise, A, Mokini, Z, Molin, A, Molto, L, Monea, M, Montalto, F, Montgomery, J, Montgomery, C, Montillo, G, Moore, S, Moore, F, Moreira, Z, Moreno, T, Moreno, R, Moret, E, Moreton, S, Morgan, M, Moro Velasco, C, Morri, D, Moull, A, Moura, F, Mraz, P, Mrozek, K, Mukhtar, K, Muniyappa, S, Murray, H, Murthy, B, Mushambi, M, Nadolski, M, Nardelli, P, Nardin, G, Navarro Perez, R, Naveiro, A, Negri, M, Nesek Adam, V, Neskovic, V, Neuwersch, S, Neves, M, Nguyen, B, Ni Eochagain, A, Nicholas, C, Nightingale, J, Norrie, K, Novak-Jankovic, V, Novakova, A, Novillo, M, Numan, S, 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M, Zuleika, M, Zupaneie, D, Kirmeier E., Eriksson L. I., Lewald H., Jonsson Fagerlund M., Hoeft A., Hollmann M., Meistelman C., Hunter J. M., Ulm K., Blobner M., Abad Gurumeta A., Abernethy C., Abigail P., Achaibar K., Adam E., Afshari A., Agudelo Montoya M. E., Akgun F. N., Aletti G., Alkis N., Allan K., Allan A., Allaouchiche B., Allcock C., Almasy E., Amey I., Amigoni M., Andersen E., Andersson P., Anipchenko N., Antunes P., Armstrong E., Aslam T. N., Aslin B., Assuncao J. P., Ausserer J., Avvai M., Awad N., Ayas Montero B., Ayuso M., Azevedo P., Badarau V., Badescu R., Baiardo Redaelli M., Baird C., Baird Y., Baker T., Balaji P., Balan C., Balandin A., Balescu-Arion C., Baliuliene V., Baltasar Isabel J., Baluch S. N., Bandrabur D., Bankewitz C., Barber K., Barbera F., Barcraft-Barnes H., Barletti V., Barnett G., Baron K., Barros A., Barsan V., Bartlett P., Batistaki C., Baumgarten G., Baytas V., Beauchamp N., Becerra Cayetano I. A., Bell S., Bellandi M., Belletti A., Belmonte Cuenca J., Benitez-Cano A., Beretta L., Berger M., Bergmann N., Bergmark K., Bermudez Lopez M., Bernotaite M., Beurskens C., Bidd H., Bifulco F., Bignami E., Bilic A., Bilskiene D., Bischoff P., Bishop L., Bjonness T., Blaylock H., Blethyn K., Blincoe T., Blokhin I., Blunt N., Boer C., Bois G., Bonicolini E., Booth J., Borecka-Kedzierska M., Borstnar K., Borys M., Boselli E., Bouvet L., Bouwman A., Bowen L., Bowrey S., Boxall L., Bozic T., Bradley T., Branco T., Brazzi L., Brazzoni M., Brear T., Brogly N., Brohi F., Broms J., Bubliauskas A., Bucolo G. E., Buerkle H., Buggy D., Buhre W., Bukauskas T., Butturini F., Byttner A., Cabrera Diaz I., Calderon A., Calhau R., Callejo A., Cammu G., Campesato M., Can O. S., Candeias M., Cantor A., Carise E., Carmona C., Carreteiro J., Carrieri C., Carter A., Casal M., Casanova I., Cascella M., Casero L. M., Casiraghi G. M., Castelo-Branco L., Castro Arranz C., Cernea D. D., Cervantes J., Chandler B., Charnock R., Chatzimicali A., Chinery E., Chishti A., Chondhury P., Christie E., Christodoudiles G., Ciardo S., Cimpeanu L., Cindea I., Cinnella G., Clark S., Clayton M., Cocu S., Collyer T., Colvin C., Cope S., Copeta F., Copotoiu S. -M., Correia de Barros F., Corso R. M., Cortegiani A., Costa G., Cowton A., Cox N., Craig J., Cricca V., Cronin J., Cunha M., Cuomo A., Curley K., Czuczwar M., Dabrowska D., Damster S., Danguy des Deserts M., Daniliuc A., Danninger T., Darwish I., Dascalu C., Davies K., Davies S., De Boer H., De Flaviis A., De Selincourt G., Deana C., Debaene B., Debreceni G., Dedhia J., Delgado Garcia I., Della Rocca G., Delroy-Buelles L., Desai T., Dhillon P., Di Giacinto I., Di Mauro P., Diaz Gomez T. V., Dimitrovski A., Dinic V., Dirzu D. -S., Divander M. B., Dolinar J., Domingues S., Doolan J., Downes C., Dragoescu N. 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M., Guarnieri M., Guclu C., Guerrero Diez M., Gunenc F., Gunther U., Gupta P., Guttenthaler V., Hack Y., Hafisayena A., Hagau N., Haldar J., Hales D., Hanci V., Hanna-Jumma S., Harazim H., Harlet P., Harper D., Harris B., Harvey O., Hashimi M., Hawkins L., Hayes C., Heaton J., Heier T., Helliwell L., Hemmes S., Henderson K., Hermanides J., Hermanns H., Herrera Hueso B., Hestenes S., Hettiarachchi R., Highgate J., Hodgson K., Hoelbling D., Holland J., Horhota L., Hormis A., Hribar R., Hua A., Humphreys S., Humphries R., Humplikova S., Hunt J., Husnain A., Hussein A., Hyams B., Iannuccelli F., Ilette K., Ilyas C., Inan T., India I., Ionitav V., Irwin F., Jain V., Janez B., Jankovic R., Jenkins S., Jenko M., Jimenez R., Jimenez Gomez B., Joachim S., Joelsson-Alm E., John J., Jonikaite L., Jovic M., Jungwirth B., Junke E., Kabakov B., Kadaoui S. -D., Kanski A., Karadag S., Karbonskiene A., Karjagin J., Kasnik D., Katanolli F., Katsika E., Kaufmann K., Keane H., Kelly M., Kent M., Keraitiene G., Khudhur A., Khuenl-Brady K., Kidd L., King S., Kirchgassner K., Klancir T., Klucniks A., Knotzer J., Knowlden P., Koers L., Kompan J., Koneti K. K., Kooij F., Koolen E., Koopman - van Gemert A. W. M. M., Kopp K., Korfiotis D., Korolkov O., Kosinova M., Kostenberger M., Kotzinger O., Kovacevic M., Kranke P., Kranke E., Kraus C., Kraus S., Kubitzek C., Kucharski R., Kucukguclu S., Kudrashou A., Kumar V., Kummen L., Kunit C., Kushakovsky V., Kuvaki B., Kuzmanovska B., Kyttari A., Landoni G., Lau G., Lazarev K., Legett S., Legrottaglie A. M., Leonardi S., Leong M., Lercher H., Leuvrey M., Leva B., Levstek M., Limb J., Lindholm E., Linton F., Liperi C., Lipski F., Lirk P., Lisi A., Liskova K., Lluch Oltra A., Loganathan V., Lombardi S., Lopez E., Lopez Rodriguez M., Lorenzini L., Lowicka M., Lugovoy A., Luippold M., Lumb A., Macas A., Macgregor M., Machado H., Maciariello M., Madeira I., Maitan S., Majewski J., Maldini B., Malewski G., Manfredini L., Manner O., Marchand B., Marcu A., Margalef J., Margarson M., Marinheiro L., Markic A., Markovic Bozic J., Marrazzo F., Martin J., Martin Ayuso M., Martinez E., Martino E. A., Martinson V., Marusic-Gaser K., Mascarenhas C., Mathis C., Matsota P., Mavrommati E., Mazul Sunko B., McCourt K., McGill N., McKee R., Meco B. C., Meier S., Melbourne S., Melbybrathen G., Meli A., Melia A., Melotti R. M., Menga M. R., Mercer P., Merotra S., Mescolini S., Metterlein T., Michalov M., Michlig S., Midgley S., Milic M., Milojevic M., Minana A., Minto G., Mirabella L., Mirea L., Mittelstadt L., Moeglen A., Moise A., Mokini Z., Molin A., Molto L., Monea M. C., Montalto F., Montgomery J., Montgomery C., Montillo G., Moore S., Moore F., Moreira Z., Moreno T., Moreno R., Moret E., Moreton S., Morgan M., Moro Velasco C., Morri D., Moull A., Moura F., Mraz P., Mrozek K., Mukhtar K., Muniyappa S., Murray H., Murthy B. V., Mushambi M., Nadolski M., Nardelli P., Nardin G., Navarro Perez R., Naveiro A., Negri M., Nesek Adam V., Neskovic V., Neuwersch S., Neves M., Nguyen B., Ni Eochagain A., Nicholas C., Nightingale J., Norrie K., Novak-Jankovic V., Novakova A., Novillo M., Numan S., Oduro-Dominah L., Oldner A., Oliveira I., Ologoiu D., Oloktsidou I., O'Reilly R., Orlando A., Ovezov A., Ozbilgin S., Paal P., Padin Barreiro L., Palugniok R., Papaioannou A., Papapostolou K., Paranthaman P., Pardey Bracho G., Parente S., Parfeni A., Pasin L., Passey S., Pastor E., Patch S., Patil A., Paunescu M. -A., Pehboeck D., Pereira M., Pereira C., Perez Caballero P., Perez Garcia A., Perez Soto A., Perez Tejero G., Perez-Cerda F., Pesenti A., Petta R., Philippe S., Pickering D., Pico Veloso J., Pina P., Pinho-Oliveira V., Pinol S., Pinto R., Pistidda L., Pitterle M., Piwowarczyk P., Plotnikova O., Pohl H., Poldermann J., Polkovicova L., Pompei L., Popescu M., Popovic R., Pota V., Potocnik M., Potrec B., Potter A., Pramod N., Prchalova M., Preckel B., Pugh R., Pulletz M., Radoeshki A., Rafi A., Ragazzi R., Raineri Santi M., Rajamanickam T., Rajput Z., Ramachandran R., Ramasamy R., Ramessur S., Rao R., Rasmussen A., Rato A., Razaque U., Real Navacerrada M. I., Reavley C., Reid J., Reschreiter H., Rial E., Ribas Carrasco P., Ribeiro S., Rich N., Richardson L., Rimaitis K., Rimaitis M., Ringvold E. -M., Ripke F., Ristescu I., Ritchie K., Rodenas F., Rodrigues P., Rogers E., Rogerson D., Romagnoli S., Romero E., Rondovic G., Rose B. O., Roth W., Rotter M. -T., Rousseau G., Rudjord A., Rueffert H., Rundgren M., Rupprecht K., Rushton A., Russotto V., Rypulak E., Ryszka M., Sa J., Sa Couto P., Saby S., Sagic J., Saleh O., Sales G., Sanchez Sanchez Y., Sanghera S., Sanli Karip C., Santiveri Papiol F. J., Santos S., Sarno S., Saul D., Saunders D., Savic N., Scalco L., Scanlon D., Schaller S., Schax C., Scheffer G. J., Schening A., Schiavone V., Schmidt-Ehrenberg F., Schmidt-Mutter C., Schonberg C., Schopflin C., Schreiber J. -U., Schultz M., Schurig M., Scott C., Sebestian S., Sehgal S., Sem V., Semenas E., Serafini E., Serchan P., Shields M., Shobha R., Shosholcheva M., Siamansour T., Siddaiah N., Siddiqi K., Sinclair R., Singh P., Singh R., Sinha A., Skinner A., Smee E., Smekalova O., Smith N., Smith T., Smitz C., Smole D., Sojcic N., Soler Pedrola M., Somanath S., Sonksen J., Sorella M. C., Sormus A., Soro M., Soto C., Spada A., Spadaro S., Spaeth J., Sparr H., Spielmann A., Spindler-Vesel A., Stamelos M., Stancombe L L., Stanculescu A., Standl T., Standley T., Stanek O., Stanisavljevic S., Starczewska M., Stauble C., Steen J., Stefan O. M., Stell E., Stera C., Stevens M., Stoerckel M., Stosic B., Stourac P., Stroumpoulis K., Struck R., Suarez de la Rica A., Sultanpori A., Sundara Rajan R., Suying O., Svensen C., Swan L., Syrogianni P., Sysiak J., Szederjesi J., Taddei S., Tan Hao E., Tanou V., Tarabova K., Tardaguila Sancho P., Tarroso M., Tartaglione M., Taylor E., Tbaily L., Telford R., Terenzoni M., Theodoraki K., Thornley H., Tiganiuc L., Toim H., Tomescu D., Tommasino C., Toni J., Toninelli A., Toretti I., Townley S., Trepenaitis D., Trethowan B., Tsaousi G., Tsiftsi A., Tudor A., Turan G., Turhan S. C., Unic-Stojanovic D., Unterbuchner C., Unzueta C., Uranjek J., Ursic T., Vaida S., Valldeperas Ferrer S., Valldeperas Hernandez M. I., Valsamidis D., Van Beek R., Van dasselaer N., Van Der Beek T., Van Duivenvoorde Y., van Klei W. A., Van Poorter F., Van Zaane B., Van Zundert T., Van Zyl R., Vargas Munoz A. M., Varsani N., Vasconcelos P., Vassilakis G., Vecchiatini T., Vecera L., Vercauteren M., Verdouw B., Verheyen V., Verri M., Vicari Sottosanti L. G., Vico M., Vidal Mitjans P., Vilardi A., Vissicchio D., Vitale G., Vitkovic B., Vizcaychipi M. P., Voicu A., Voje M., Volfova I., Volta C. A., Von Lutterotti T., von Tiesenhausen A., Vrecic-Slabe S., Vukcevic D., Vukovic R., Vullo P. A., Wade A., Wallberg H., Wallden J., Wallner J., Walther Sturesson L., Watson D., Weber S., Wegiel Leskiewiq A., Weller D., Wensing C., Werkmann M., Westberg H., Wikstrom E., Williams B., Wilson R., Wirth S., Wittmann M., Wood L., Wright S., Zachoval C., Zambon M., Zampieri S., Zampone S., Zangrillo A., Zani G., Zavackiene A., Zieglerder R., Zonneveldt H., Zsisku L., Zucker T. -P., Zukowski M., Zuleika M., Zupaneie D., Kirmeier, E, Eriksson, L, Lewald, H, Jonsson Fagerlund, M, Hoeft, A, Hollmann, M, Meistelman, C, Hunter, J, Ulm, K, Blobner, M, Abad Gurumeta, A, Abernethy, C, Abigail, P, Achaibar, K, Adam, E, Afshari, A, Agudelo Montoya, M, Akgun, F, Aletti, G, Alkis, N, Allan, K, Allan, A, Allaouchiche, B, Allcock, C, Almasy, E, Amey, I, Amigoni, M, Andersen, E, Andersson, P, Anipchenko, N, Antunes, P, Armstrong, E, Aslam, T, Aslin, B, Assuncao, J, Ausserer, J, Avvai, M, Awad, N, Ayas Montero, B, Ayuso, M, Azevedo, P, Badarau, V, Badescu, R, Baiardo Redaelli, M, Baird, C, Baird, Y, 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K., Kooij F., Koolen E., Koopman - van Gemert A. W. M. M., Kopp K., Korfiotis D., Korolkov O., Kosinova M., Kostenberger M., Kotzinger O., Kovacevic M., Kranke P., Kranke E., Kraus C., Kraus S., Kubitzek C., Kucharski R., Kucukguclu S., Kudrashou A., Kumar V., Kummen L., Kunit C., Kushakovsky V., Kuvaki B., Kuzmanovska B., Kyttari A., Landoni G., Lau G., Lazarev K., Legett S., Legrottaglie A. M., Leonardi S., Leong M., Lercher H., Leuvrey M., Leva B., Levstek M., Limb J., Lindholm E., Linton F., Liperi C., Lipski F., Lirk P., Lisi A., Liskova K., Lluch Oltra A., Loganathan V., Lombardi S., Lopez E., Lopez Rodriguez M., Lorenzini L., Lowicka M., Lugovoy A., Luippold M., Lumb A., Macas A., Macgregor M., Machado H., Maciariello M., Madeira I., Maitan S., Majewski J., Maldini B., Malewski G., Manfredini L., Manner O., Marchand B., Marcu A., Margalef J., Margarson M., Marinheiro L., Markic A., Markovic Bozic J., Marrazzo F., Martin J., Martin Ayuso M., Martinez E., Martino E. A., Martinson V., Marusic-Gaser K., Mascarenhas C., Mathis C., Matsota P., Mavrommati E., Mazul Sunko B., McCourt K., McGill N., McKee R., Meco B. C., Meier S., Melbourne S., Melbybrathen G., Meli A., Melia A., Melotti R. M., Menga M. R., Mercer P., Merotra S., Mescolini S., Metterlein T., Michalov M., Michlig S., Midgley S., Milic M., Milojevic M., Minana A., Minto G., Mirabella L., Mirea L., Mittelstadt L., Moeglen A., Moise A., Mokini Z., Molin A., Molto L., Monea M. C., Montalto F., Montgomery J., Montgomery C., Montillo G., Moore S., Moore F., Moreira Z., Moreno T., Moreno R., Moret E., Moreton S., Morgan M., Moro Velasco C., Morri D., Moull A., Moura F., Mraz P., Mrozek K., Mukhtar K., Muniyappa S., Murray H., Murthy B. V., Mushambi M., Nadolski M., Nardelli P., Nardin G., Navarro Perez R., Naveiro A., Negri M., Nesek Adam V., Neskovic V., Neuwersch S., Neves M., Nguyen B., Ni Eochagain A., Nicholas C., Nightingale J., Norrie K., Novak-Jankovic V., Novakova A., Novillo M., Numan S., Oduro-Dominah L., Oldner A., Oliveira I., Ologoiu D., Oloktsidou I., O'Reilly R., Orlando A., Ovezov A., Ozbilgin S., Paal P., Padin Barreiro L., Palugniok R., Papaioannou A., Papapostolou K., Paranthaman P., Pardey Bracho G., Parente S., Parfeni A., Pasin L., Passey S., Pastor E., Patch S., Patil A., Paunescu M. -A., Pehboeck D., Pereira M., Pereira C., Perez Caballero P., Perez Garcia A., Perez Soto A., Perez Tejero G., Perez-Cerda F., Pesenti A., Petta R., Philippe S., Pickering D., Pico Veloso J., Pina P., Pinho-Oliveira V., Pinol S., Pinto R., Pistidda L., Pitterle M., Piwowarczyk P., Plotnikova O., Pohl H., Poldermann J., Polkovicova L., Pompei L., Popescu M., Popovic R., Pota V., Potocnik M., Potrec B., Potter A., Pramod N., Prchalova M., Preckel B., Pugh R., Pulletz M., Radoeshki A., Rafi A., Ragazzi R., Raineri Santi M., Rajamanickam T., Rajput Z., Ramachandran R., Ramasamy R., Ramessur S., Rao R., Rasmussen A., Rato A., Razaque U., Real Navacerrada M. I., Reavley C., Reid J., Reschreiter H., Rial E., Ribas Carrasco P., Ribeiro S., Rich N., Richardson L., Rimaitis K., Rimaitis M., Ringvold E. -M., Ripke F., Ristescu I., Ritchie K., Rodenas F., Rodrigues P., Rogers E., Rogerson D., Romagnoli S., Romero E., Rondovic G., Rose B. O., Roth W., Rotter M. -T., Rousseau G., Rudjord A., Rueffert H., Rundgren M., Rupprecht K., Rushton A., Russotto V., Rypulak E., Ryszka M., Sa J., Sa Couto P., Saby S., Sagic J., Saleh O., Sales G., Sanchez Sanchez Y., Sanghera S., Sanli Karip C., Santiveri Papiol F. J., Santos S., Sarno S., Saul D., Saunders D., Savic N., Scalco L., Scanlon D., Schaller S., Schax C., Scheffer G. J., Schening A., Schiavone V., Schmidt-Ehrenberg F., Schmidt-Mutter C., Schonberg C., Schopflin C., Schreiber J. -U., Schultz M., Schurig M., Scott C., Sebestian S., Sehgal S., Sem V., Semenas E., Serafini E., Serchan P., Shields M., Shobha R., Shosholcheva M., Siamansour T., Siddaiah N., Siddiqi K., Sinclair R., Singh P., Singh R., Sinha A., Skinner A., Smee E., Smekalova O., Smith N., Smith T., Smitz C., Smole D., Sojcic N., Soler Pedrola M., Somanath S., Sonksen J., Sorella M. C., Sormus A., Soro M., Soto C., Spada A., Spadaro S., Spaeth J., Sparr H., Spielmann A., Spindler-Vesel A., Stamelos M., Stancombe L L., Stanculescu A., Standl T., Standley T., Stanek O., Stanisavljevic S., Starczewska M., Stauble C., Steen J., Stefan O. M., Stell E., Stera C., Stevens M., Stoerckel M., Stosic B., Stourac P., Stroumpoulis K., Struck R., Suarez de la Rica A., Sultanpori A., Sundara Rajan R., Suying O., Svensen C., Swan L., Syrogianni P., Sysiak J., Szederjesi J., Taddei S., Tan Hao E., Tanou V., Tarabova K., Tardaguila Sancho P., Tarroso M., Tartaglione M., Taylor E., Tbaily L., Telford R., Terenzoni M., Theodoraki K., Thornley H., Tiganiuc L., Toim H., Tomescu D., Tommasino C., Toni J., Toninelli A., Toretti I., Townley S., Trepenaitis D., Trethowan B., Tsaousi G., Tsiftsi A., Tudor A., Turan G., Turhan S. C., Unic-Stojanovic D., Unterbuchner C., Unzueta C., Uranjek J., Ursic T., Vaida S., Valldeperas Ferrer S., Valldeperas Hernandez M. I., Valsamidis D., Van Beek R., Van dasselaer N., Van Der Beek T., Van Duivenvoorde Y., van Klei W. A., Van Poorter F., Van Zaane B., Van Zundert T., Van Zyl R., Vargas Munoz A. M., Varsani N., Vasconcelos P., Vassilakis G., Vecchiatini T., Vecera L., Vercauteren M., Verdouw B., Verheyen V., Verri M., Vicari Sottosanti L. G., Vico M., Vidal Mitjans P., Vilardi A., Vissicchio D., Vitale G., Vitkovic B., Vizcaychipi M. P., Voicu A., Voje M., Volfova I., Volta C. A., Von Lutterotti T., von Tiesenhausen A., Vrecic-Slabe S., Vukcevic D., Vukovic R., Vullo P. A., Wade A., Wallberg H., Wallden J., Wallner J., Walther Sturesson L., Watson D., Weber S., Wegiel Leskiewiq A., Weller D., Wensing C., Werkmann M., Westberg H., Wikstrom E., Williams B., Wilson R., Wirth S., Wittmann M., Wood L., Wright S., Zachoval C., Zambon M., Zampieri S., Zampone S., Zangrillo A., Zani G., Zavackiene A., Zieglerder R., Zonneveldt H., Zsisku L., Zucker T. -P., Zukowski M., Zuleika M., and Zupaneie D.

Abstract

Background: Results from retrospective studies suggest that use of neuromuscular blocking agents during general anaesthesia might be linked to postoperative pulmonary complications. We therefore aimed to assess whether the use of neuromuscular blocking agents is associated with postoperative pulmonary complications. Methods: We did a multicentre, prospective observational cohort study. Patients were recruited from 211 hospitals in 28 European countries. We included patients (aged ≥18 years) who received general anaesthesia for any in-hospital procedure except cardiac surgery. Patient characteristics, surgical and anaesthetic details, and chart review at discharge were prospectively collected over 2 weeks. Additionally, each patient underwent postoperative physical examination within 3 days of surgery to check for adverse pulmonary events. The study outcome was the incidence of postoperative pulmonary complications from the end of surgery up to postoperative day 28. Logistic regression analyses were adjusted for surgical factors and patients' preoperative physical status, providing adjusted odds ratios (ORadj) and adjusted absolute risk reduction (ARRadj). This study is registered with ClinicalTrials.gov, number NCT01865513. Findings: Between June 16, 2014, and April 29, 2015, data from 22 803 patients were collected. The use of neuromuscular blocking agents was associated with an increased incidence of postoperative pulmonary complications in patients who had undergone general anaesthesia (1658 [7·6%] of 21 694); ORadj 1·86, 95% CI 1·53–2·26; ARRadj −4·4%, 95% CI −5·5 to −3·2). Only 2·3% of high-risk surgical patients and those with adverse respiratory profiles were anaesthetised without neuromuscular blocking agents. The use of neuromuscular monitoring (ORadj 1·31, 95% CI 1·15–1·49; ARRadj −2·6%, 95% CI −3·9 to −1·4) and the administration of reversal agents (1·23, 1·07–1·41; −1·9%, −3·2 to −0·7) were not associated with a decreased risk of postoperative pulmonary

Published
2019

24. La montagne comme modèle d’enregistrement des mutations « culturelles » précoces : les cas de l’Azilien et du Sauveterrien en Pyrénées catalanes

Author

Martzluff, Michel, Moreno, Jorge Martinez, Casanova i Marti, Joel, and Mora Torcal, Rafael

Subjects
Pyrénées, paleoenvironment, vida rural, montagne, montana, Protostoria, mountain, Alps, Pyrenees, paleo-entorno, montaña, vita rurale, HBLA, vie rurale, paléoenvironnement, rural life, impact humain, Archaeology, sienze naturali, Pirineos, HIS002000, Protohistoria, Alpi, peuplement, Protohistory
Abstract

Les Pyrénées ne comptent que quatre sites établis autour de 1 000 m qui peuvent témoigner de l’occupation de l’étage montagnard avant le Néolithique ancien. À partir des vallées d’Andorre et sur le flanc sud de la chaîne orientale, les abris de Guilanya et Margineda permettent d’analyser les mutations environnementales et les évolutions dans la culture matérielle et spirituelle des groupes de chasseurs-collecteurs de la fin du Tardiglaciaire à l’Holocène ancien. Au côté d’originalités culturelles (incursion d’Aziliens du versant nord pendant l’Alleröd, Sauveterriens sans microlithes cantonnés dans les Pyrénées sèches), les innovations techniques bien cernées en stratigraphie sont plus précocement attestées au cœur de la chaîne axiale qu’en bordure du littoral et dans les piémonts où certains décalages techno-typologiques, tel l’Épimagdalénien, ont été individualisés. In the Pyrenees, mountain settlements higher than 1000 m are scarce before the Early Neolithic. Balma Guilanyà and Balma Margineda, rock-shelters located in the south-eastern face of the Pyrenees, allow analyzing the ecological and the hunter-gatherer adaptations along the limit Late Glacial/Early Holocene. In this area, some cultural processes (like the sudden apparition of the Azilian from the north Pyrenees in the Allerød, or the development of a Sauveterrien stage without standardized microlithic artifacts in the south Pyrenees) suggest that these technical innovation are detected sooner in the core of the mountain chain than in peripheral areas as the piedmont or the coast, where some techno-typological endurances (Epimagdalenian) has been recognized.

Published
2020

26. The D-CIXS X-ray spectrometer on the SMART-1 mission to the Moon—First results

Author

Grande, M., Kellett, B.J., Howe, C., Perry, C.H., Swinyard, B., Dunkin, S., Huovelin, J., Alha, L., D’Uston, L.C., Maurice, S., Gasnault, O., Couturier-Doux, S., Barabash, S., Joy, K.H., Crawford, I.A., Lawrence, D., Fernandes, V., Casanova, I., Wieczorek, M., Thomas, N., Mall, U., Foing, B., Hughes, D., Alleyne, H., Russell, S., Grady, M., Lundin, R., Baker, D., Murray, C.D., Guest, J., and Christou, A.

Published
2007
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33. Efficient bioactive oligonucleotide-protein conjugation for cell-targeted cancer therapy

Author

Avino, A, Unzueta, U, Cespedes, MV, Casanova, I, Vazquez, E, Villaverde, A, Mangues, R, and Eritja, R

Subjects
nanoparticle protein, lipids, 2'-deoxy-5-fluorouridine, Oligonucleotide-protein conjugate, polymers
Abstract

Oligonucleotide-protein conjugates have important applications in biomedicine. Simple and efficient methods are described for the preparation of these conjugates. Specifically, we describe a new method in which a bifunctional linker is attached to thiol-oligonucleotide to generate a reactive intermediate that is used to link to the protein. Having similar conjugation efficacy compared with the classical method in which the bifunctional linker is attached first to the protein, this new approach produces significantly more active conjugates with higher batch to batch reproducibility. In a second approach, direct conjugation is proposed using oligonucleotides carrying carboxyl groups. These methodologies have been applied to prepare nanoconjugates of an engineered nanoparticle protein carrying a T22 peptide with affinity for the CXCR4 chemokine receptor and oligomers of the antiproliferative nucleotide 2'-deoxy-5-fluorouridine in a very efficient way. The protocols have potential uses for the functionalization of proteins, amino-containing polymers or amino-lipids in order to produce complex therapeutic nucleic acid delivery systems.

Published
2019

34. MEMORIS: a wide angle camera for the BepiColombo mission

Author

Cremonese, G., Capria, M.T., Achilli, V., Angrilli, F., Baggio, P., Barbieri, C., Baumgardner, J., Bistacchi, N., Capaccioni, F., Caporali, A., Casanova, I., De Bei, S., Forlani, G., Fornasier, S., Hunten, D., Ip, W.H., Lazzarin, M., Longhi, I., Marinangeli, L., Marzari, F., Massironi, M., Masson, P., Mendillo, M., Pain, B., Preti, G., Ragazzoni, R., Raitala, J., Salemi, G., Sgavetti, M., Sprague, A., Suetta, E., Tordi, M., Verani, S., Wilson, J.K., and Wilson, L.

Published
2004
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36. The D-CIXS X-ray mapping spectrometer on SMART-1

Author

Grande, M, Browning, R, Waltham, N, Parker, D, Dunkin, S.K, Kent, B, Kellett, B, Perry, C.H, Swinyard, B, Perry, A, Feraday, J, Howe, C, McBride, G, Phillips, K, Huovelin, J, Muhli, P, Hakala, P.J, Vilhu, O, Laukkanen, J, Thomas, N, Hughes, D, Alleyne, H, Grady, M, Lundin, R, Barabash, S, Baker, D, Clark, P.E, Murray, C.D, Guest, J, Casanova, I, d'Uston, L.C, Maurice, S, Foing, B, Heather, D.J, Fernandes, V, Muinonen, K, Russell, S.S, Christou, A, Owen, C, Charles, P, Koskinen, H, Kato, M, Sipila, K, Nenonen, S, Holmstrom, M, Bhandari, N, Elphic, R, and Lawrence, D

Published
2003
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37. Scientific rationale for the D-CIXS X-ray spectrometer on board ESA's SMART-1 mission to the Moon

Author

Dunkin, S.K, Grande, M, Casanova, I, Fernandes, V, Heather, D.J, Kellett, B, Muinonen, K, Russell, S.S, Browning, R, Waltham, N, Parker, D, Kent, B, Perry, C.H, Swinyard, B, Perry, A, Feraday, J, Howe, C, Phillips, K, McBride, G, Huovelin, J, Muhli, P, Hakala, P.J, Vilhu, O, Thomas, N, Hughes, D, Alleyne, H, Grady, M, Lundin, R, Barabash, S, Baker, D, Clark, P.E, Murray, C.D, Guest, J, d'Uston, L.C, Maurice, S, Foing, B, Christou, A, Owen, C, Charles, P, Laukkanen, J, Koskinen, H, Kato, M, Sipila, K, Nenonen, S, Holmstrom, M, Bhandari, N, Elphic, R, and Lawrence, D

Published
2003
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39. The D-CIXS X-ray spectrometer, and its capabilities for lunar science

Author

Grande, M, Dunkin, S, Heather, D, Kellett, B, Perry, C.H, Browning, R, Waltham, N, Parker, D, Kent, B, Swinyard, B, Fereday, J, Howe, C, Huovelin, J, Muhli, P, Hakala, P.J, Vilhu, O, Thomas, N, Hughes, D, Alleyne, H, Grady, M, Russell, S, Lundin, R, Barabash, S, Baker, D, Clark, P.E, Murray, C.D, Christou, A, Guest, J, Casanova, I, d'Uston, L.C, Maurice, S, Foing, B, and Kato, M

Published
2002
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40. Theoretical study of disorder and proximity effects in three-dimensional models of topological insulators

Author

Chulkov, Evgueni, Casanova i Fernàndez, Fèlix, Cartoixà Soler, Xavier, Song, Kenan, Universitat Autònoma de Barcelona. Departament de Física., Chulkov, Evgueni, Casanova i Fernàndez, Fèlix, Cartoixà Soler, Xavier, Song, Kenan, and Universitat Autònoma de Barcelona. Departament de Física.

Abstract

Aquest doctorat. El projecte cobreix les investigacions sobre aïllants topològics (TI) de la família Bi2Se3 amb diferents defectes i l'estudi d'efectes de proximitat de TI a la heteroestructura de grafè amb TI. La primera part d'aquest projecte se centra principalment en l'efecte del desordre en les propietats electròniques de TI amb gruix ultrafí ( 3 nm). S'ha trobat que la manca de coincidència de rotació entre capes quíntuples de TI pot augmentar el "gap" de volum dels TI però preservar la textura d'espín tipus Rashba en l'estat de la superfície; mentre que la hidrogenació en una superfície de TI pot ajudar a reduir l'efecte túnel quàntic i tancar el "gap" de superfície en el punt Γ amb la textura d'espín tipus Rashba per a la pel·lícula TI ultrafina. A més, aquest esquema també pot crear un altre punt Dirac (DP) en el punt M amb textura de spin tipus Dresselhaus. La segona part del projecte investiga els efectes de proximitat de TI dins de la heteroestructura de grafè / TI i el DP en el grafè es plega des del punt K / K 'a Γ punt de la zona Brillouin, a causa del plegament de la banda, trobant que l'alineació entre el substrat de TI i el grafè té un paper clau en la formació de l'estructura de la banda i la textura d'espín del grafè. La configuració d'apilament "hollow" podria induir la distorsió d'unió de Kekulé a la capa de grafè, donant com a resultat l'engrandiment del "gap" (3.2 meV) i el Rashba SOC, el que dóna com a resultat la precessió d'espín propera al Γ punt . A més, aquesta textura atípica de Rashba espín fa que la component d'espín fora del pla disminueixi gradualment a mesura que el punt k s'allunya del punt Γ, el que porta a la anisotropia de gir a la capa de grafè. D'altra banda, la configuració d'apilament "bridge" o "top" podria portar l'evident divisió de la banda en direcció lateral, que podria ser l'origen de l'efecte Edelstein en la capa de grafè; no obstant, no hi ha una anisotropia d'espín evident en aquesta configuració. Totes les prime, Este doctorado. El proyecto cubre las investigaciones sobre aislantes topológicos (TI) de la familia Bi2Se3 con diferentes defectos y el estudio de efectos de proximidad de TI en la heteroestructura de grafeno con TI. La primera parte de este proyecto se centra principalmente en el efecto del desorden en las propiedades electrónicas de TI con espesor ultrafino ( 3 nm). Se ha encontrado que la falta de coincidencia de rotación entre capas quíntuples de TI puede aumentar el "gap" de volumen de los TI pero preservar la textura de espín tipo Rashba en el estado de la superficie; mientras que la hidrogenación en una superficie de TI puede ayudar a reducir el efecto túnel cuántico y cerrar el "gap" de los estados de superficie en el punto Γ con la textura de espín tipo Rashba para la película TI ultrafina. Además, este esquema también puede crear otro punto Dirac (DP) en el punto M con textura de espín tipo Dresselhaus. La segunda parte del proyecto investiga los efectos de proximidad de TI dentro de la heteroestructura de grafeno/TI y el DP en el grafeno se pliega desde el punto K / K' a Γ punto en la zona Brillouin, debido al plegamiento de la banda, encontrando que la alineación entre el sustrato de TI y el grafeno desempeña un papel clave en la formación de la estructura de la banda y la textura de espín del grafeno. La configuración de apilamiento "hollow" podría inducir la distorsión de unión de Kekulé a la capa de grafeno, dando como resultado el agrandamiento del "gap" (3.2 meV) y el Rashba SOC, lo que da como resultado la precesión de espín cercana al Γ punto. Además, esta textura atípica de Rashba espín hace que la componente de espín fuera del plano disminuya gradualmente a medida que el punto k se aleja del punto Γ, lo que lleva a la anisotropía de giro en la capa de grafeno. Por otro lado, la configuración de apilamiento "bridge" o "top" podría traer la evidente división de la banda en dirección lateral, que podría ser el origen del efecto Edelstein en la cap, This PhD. project covers the researches on the Bi2Se3-family topological insulators (TIs) with different defects and the study of the proximity effects of TI in the heterostructure of graphene with TI. The first part of this project mainly focuses on the effect of disorder on the electronic properties of TI with ultrathin thickness ( 3 nm). It was found that rotation mismatch between quintuple of TI can enlarge the bulk gap of TI but preserve the Rashba type spin texture on the surface state; while, the hydrogenation on one TI surface can help reduce the quantum tunneling effect and close the surface gap at Γ point with Rashba type spin texture for ultrathin TI film. Furthermore, this scheme can also create another Dirac point (DP) at M point with Dresselhaus type spin texture. The second part of the project investigates in the proximity effects of TI within the heterostructure of graphene/TI and the DP on graphene is folded from K/K' point to Γ point in Brillouin zone, due to the band folding, and it was found that the alignment between TI substrate and graphene played the key role in forming the band structure and the spin texture of graphene. Hollow configuration could induce the Kekulé bonding distortion to graphene layer, mainly resulting in the enlarged gap (3.2 meV), and the Rashba SOC, resulting in the spin precession close to the Γ point. Furthermore, this atypcial Rashba spin texture has the out-of-plane spin component decrease gradually as the k point moves away from the Γ point, leading to the spin anisotropy on graphene layer. While, the bridge or the top configuration could bring the evident band splitting in lateral direction, which could be the origin of the Edelstein effect in graphene layer; however, there is no evident spin anisotropy in such configuration. All the first two parts were carried out through density functional theory (DFT) calculation and a tight binding (TB) model was built up and fitted to the DFT results in order to provide an ana

Published
2018

41. Axtrell, a new CV3 chondrite find from Texas

Author

Simon, S. B, Grossman, L, Casanova, I, Symes, S, Benoit, P, Sears, D. W. G, and Wacker, J. F

Subjects
Lunar And Planetary Exploration
Abstract

We describe a previously unreported meteorite found in Axtell, Texas, in 1943. Based on the mineralogical composition and texture of its matrix and the sizes and abundance of chondrules, we classify it as a CV3 carbonaceous chondrite. The dominant opaque phase in the chondrules is magnetite, and that in refractory inclusions is Ni-rich metal (awaruite). Axtell, therefore, belongs to the oxidized subgroup of CV3 chondrites, although unlike Allende it escaped strong sulfidation. The meteorite bears a strong textural resemblance to Allende, and its chondrule population and matrix appear to be quite similar to those of Allende, but its refractory inclusions, thermoluminescence properties, and cosmogenic Co-60 abundances are not. Our data are consistent with a terrestrial age for Axtell of approximately 100 years and a metamorphic grade slightly lower than that of Allende.

Published
1995

42. Vulvar Basal Cell Carcinoma: four case reports with immunohistochemical study

Author

García de la Fuente, María Reyes, Santacana Espasa, Maria, Vilardell, Felip, Garí Marsol, Eloi, and Casanova i Seuma, Josep M. (Josep Manel)

Subjects
Hair follicle, integumentary system, Basal cell carcinoma, Apocrine glands, Cytokeratins, female genital diseases and pregnancy complications
Abstract

Basal cell carcinomas (BCC) are the most frequent tumours in humans and normally appear in photoexposed areas of the skin. It is widely accepted that BCCs originate at follicular stem cells and consequently are very rare in nonhairy areas. Here, we report 4 cases of vulvar BCC, 3 of which were located in a vulvar semimucous area, a nonphotoexposed area, and a nonhairy area. We have determined the CK7 and CK19 profile of all cases; both are markers of simple epithelium with glandular differentiation. Interestingly, all cases were positively stained for CK7 and CK19. Considering that the vulvar region is rich in sebaceous and apocrine units, we hypothesise a glandular origin of BCCs situated in the vulvar region.

Published
2017

44. Informe relatiu a la Medalla de la Ciutat de Barcelona

Author

Institut de Cultura de Barcelona, Institut d'Estudis Catalans, Societat Catalana d’Estudis Numismàtics, and Casanova i Mandri, Rossend

Subjects
Decorations of honor, Medalles, Condecoracions, Medalles d'Honor de Barcelona, Cultura i oci, informes altres, Condecoraciones, Medals, Medallas
Abstract

Sol·licitant de l'informe: Institut de Cultura de Barcelona

Published
2017

45. Ressenyes

Author

Casanova i Berdaguer, Jordi and Rabal i Vidal, Eduard

Published
2017

46. Distribution of vanadium and melting of opaque assemblages in Efremovka CAI's

Author

Casanova, I and Grossman, L

Subjects
Geophysics
Abstract

A petrographic and chemical study of compact Type A CAI's from the Efremovka CV3 chondrite strongly suggests that the opaque assemblages (OA's) that they contain were molten at temperatures below the CAI silicate solidus, and that the V-rich magnetite presently observed in association with OA's formed by in situ oxidation of their FeNi.

Published
1993

47. Metal-rich meteorites from the aubrite parent body

Author

Casanova, I, Mccoy, T. J, and Keil, K

Subjects
Astrophysics
Abstract

Three metal-rich meteorites - Mt. Egerton, Horse Creek, and LEW 88055 - were studied and it is suggested that they formed in the aubrite parent body. LEW 85369 and 88631 may also have a common origin, but these rocks have not yet been studied in detail. This body was probably heated to about 1600 C by a very strong heat source. While molten, metal agglomerated into sizeable nodules which never segregated efficiently to form a core, but were trapped in the silicate mantle. Different clasts and lithologies in aubrites solidified and cooled under local equilibrium conditions of oxygen fugacity, and with different thermal histories. Impacts mixed clasts from throughout the parent body, creating the typical aubrite breccias.

Published
1993

48. Study of the possible link of 25-hydroxyvitamin D with Epstein-Barr virus and human herpesvirus 6 in patients with multiple sclerosis

Author

Pérez-Pérez, S., primary, Domínguez-Mozo, M. I., additional, García-Martínez, M. Á., additional, Aladro, Y., additional, Martínez-Ginés, M., additional, García-Domínguez, J. M., additional, López de Silanes, C., additional, Casanova, I., additional, Ortega-Madueño, I., additional, López-Lozano, L., additional, Torrejón, M. J., additional, Arroyo, R., additional, and Álvarez-Lafuente, R., additional

Published
2018
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49. Origin and history of chondrite regolith, fragmental and impact-melt breccias from Spain

Author

Casanova, I, Keil, K, Wieler, R, San Miguel, A, and King, E. A

Subjects
Lunar And Planetary Exploration
Abstract

Six ordinary chondrite breccias from the Museo Nacional de Ciencias Naturales, Madrid (Spain), are described and classified as follows: the solar gas-rich regolith breccia Oviedo (H5); the premetamorphic fragmental breccias Cabezo de Mayo (type 6, L-LL), and Sevilla (LL4); the fragmental breccias Canellas (H4) and Gerona (H5); and the impact melt breccia, Madrid (L6). It is confirmed that chondrites with typical light-dark structures and petrographic properties typical of regolith breccias may (Oviedo) or may not (Canellas) be solar gas-rich. Cabezo de Mayo and Sevilla show convincing evidence that they were assembled prior to peak metamorphism and were equilibrated during subsequent reheating. Compositions of olivine and low-Ca pyroxene in host chondrite and breccia clasts in Cabezo de Mayo are transitional between groups L and LL. It is suggested, based on mineralogic and oxygen isotopic compositions of host and clasts, that the rock formed on the L parent body by mixing, prior to peak metamorphism. This was followed by partial equilibrium of two different materials: the indigenous L chondrite host and exotic LL melt rock clasts.

Published
1990

50. Classification of four ordinary chondrites from Spain

Author

Mccoy, T. J, Keil, Klaus, Casanova, I, and Wieler, R

Subjects
Lunar And Planetary Exploration
Abstract

Based on optical microsocpy and electron microprobe analysis of mafic minerals, four previously poorly described ordinary chondrites from Spain are classified. The classifications of Guarena (H6), Olmedilla de Alarcon (H5) and Reliegos (L5) are confirmed. Molina is reclassified as H5, based on new data.

Published
1990

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