1,012 results on '"Casanova, C."'
Search Results
2. Associations of serum sclerostin levels with body composition, pulmonary function, and exacerbations in COPD patients
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Amado, C.A., García-Unzueta, M., Agüero, J., Martín-Audera, P., Fueyo, P., Lavín, B.A., Guerra, A.R., Muñoz, P., Tello, S., Berja, A., and Casanova, C.
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- 2022
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3. Determination of Arable Weed Patterns according to Temperature and Latitude Gradient in Central and Southern Spain
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Gandia, M. L., primary, Casanova, C., additional, Sánchez, F.J., additional, Tenorio, J. L., additional, and Santín-Montanyá, M. I., additional
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- 2021
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4. Diseño y validación del Cuestionario de Función Sexual del Hombre, FSH
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Sánchez-Sánchez, F., Ferrer-Casanova, C., Ponce-Buj, B., Sipán-Sarrión, Y., Jurado-López, A.R., San Martin-Blanco, C., Tijeras-Úbeda, M.J., and Pascual Regueiro, N.
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- 2020
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5. Diseño y validación de la segunda edición del Cuestionario de Función Sexual de la Mujer, FSM-2
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Sánchez-Sánchez, F., Ferrer-Casanova, C., Ponce-Buj, B., Sipán-Sarrión, Y., Jurado-López, A.R., San Martin-Blanco, C., Tijeras-Úbeda, M.J., and Ferrández Infante, A.
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- 2020
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6. Circulating miR-1246 in the Progression of Chronic Obstructive Pulmonary Disease (COPD) in Patients from the BODE Cohort
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Cazorla-Rivero S, Mura-Escorche G, Gonzalvo-Hernández F, Mayato D, Córdoba-Lanús E, and Casanova C
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copd progression ,mirnas ,emphysema. ,Diseases of the respiratory system ,RC705-779 - Abstract
Sara Cazorla-Rivero,1,2 Glorian Mura-Escorche,1,2 Francisca Gonzalvo-Hernández,3 Delia Mayato,1 Elizabeth Córdoba-Lanús,1,2,4,* Ciro Casanova1– 3,* 1Research Unit, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain; 2University of La Laguna, San Cristóbal de La Laguna, Tenerife, Spain; 3Pulmonary Department, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain; 4Instituto de Enfermedades Tropicales y Salud Pública de Canarias (IUETSPC), San Cristóbal de La Laguna, Tenerife, Spain*These authors contributed equally to this workCorrespondence: Elizabeth Córdoba-LanúsUniversity of La Laguna- IUETSPC, Av. Astrofísico Francisco Sanchez. Campus Anchieta, Apartado 456, San Cristobal de la Laguna CP 38200, Tenerife, SpainEmail acordoba@ull.edu.esBackground: COPD is characterized by a persistent inflammatory response, especially against cigarette smoke. COPD patients may develop varying degrees of emphysematous destruction of the lungs. A pathophysiological role for miRNAs in COPD has been suggested in several studies. We examined changes in microRNAs expression profile during 10 years follow-up in relation to COPD progression.Methods: Clinical and lung function parameters were registered from every subject included in the study. miRNAs expression was determined in 14 serum samples from 7 patients in two moments (4 smokers with COPD (BODE cohort) and 3 smokers without COPD) by next generation sequencing (NGS) at baseline and after 10 years follow-up. A validation study was performed by qPCR in 20 patients with COPD (13 emphysema-diagnosed by CTscan) and 10 smoker controls at baseline and after 10 years follow-up. hsa-miRNA-20a-5p and hsa-let-7d-5p were used as endogenous controls.Results: A total of 198 miRNAs (≥ 10TPM) were identified by NGS. Between these, hsa-miR-1246 was found significantly downregulated in COPD patients after 10 years when compared to baseline (p< 0.0001, FDR=0.05). Seventy-five percent of these patients had an emphysema diagnose. In the validation analysis, when analyzed longitudinally, hsa-miR-1246 was significantly downregulated in COPD patients with emphysema after 10 years (p= 0.019). However, no association was found between the expression of miR-1246 and any other lung function parameters (FEV1, PaO2, DLCO, IC/TLC) within the follow-up period. GO and KEGG enrichment analysis revealed miR-1246 to be associated with target genes in several pathways involved in COPD/emphysema development.Conclusion: Our findings suggest that hsa-miR-1246 may act as a biomarker of emphysema in COPD. Functional analysis is guaranteed to elucidate its role in COPD.Keywords: COPD progression, miRNAs, emphysema
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- 2020
7. A Proposed Approach to Chronic Airway Disease (CAD) Using Therapeutic Goals and Treatable Traits: A Look to the Future
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Pérez de Llano L, Miravitlles M, Golpe R, Alvarez-Gutiérrez FJ, Cisneros C, Almonacid C, Martinez-Moragon E, Gonzalez-Barcala FJ, Ramos-Barbón D, Plaza V, Lopez-Campos JL, de-Torres JP, Casanova C, Garcia Rivero JL, Rodriguez Hermosa J, Calle Rubio M, Soler-Cataluña JJ, and Cosio BG
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airflow obstruction ,biomarker ,personalised medicine ,copd asthma overlap ,Diseases of the respiratory system ,RC705-779 - Abstract
Luis Pérez de Llano,1 Marc Miravitlles,2 Rafael Golpe,1 Francisco Javier Alvarez-Gutiérrez,3 Carolina Cisneros,4 Carlos Almonacid,5 Eva Martinez-Moragon,6 Francisco-Javier Gonzalez-Barcala,7 David Ramos-Barbón,8 Vicente Plaza,8 Jose Luis Lopez-Campos,3 Juan Pablo de-Torres,9 Ciro Casanova,10 Juan Luis Garcia Rivero,11 Juan Rodriguez Hermosa,12 Myriam Calle Rubio,12 Juan Jose Soler-Cataluña,13 Borja G Cosio14 1Pneumology Service, University Hospital Lucus Augusti, Lugo, EOXI Cervo, Lugo, Monforte, Spain; 2Pneumology Service, Hospital Universitari Vall d’Hebron, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Barcelona Hospital Campus, CIBERES, Barcelona, Spain; 3Pneumology Service, Hospital Universitario Virgen del Rocio, Seville, Spain; 4Pneumology Service, La Princesa University Hospital, Madrid, Research Institute La Princesa IIP, Madrid, Spain; 5Pneumology Service, Ramón y Cajal Hospital (Ramon y Cajal Health Research Institute, IRYCIS), Madrid, Spain; 6Pneumology Service, Hospital Universitario Dr Peset, Valencia, Spain; 7Faculty of Medicine at the University of Santiago de Compostela, Pneumology Service of the University Clinical Hospital of Santiago de Compostela, CIBERES, Santiago de Compostela, Spain; 8Pneumology Service, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; 9Division of Respirology and Sleep Medicine, Queen’s University, Canada, ON, Canada; 10Pneumology Service, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz De Tenerife, Spain; 11Pneumology Service, Hospital de Laredo, Laredo, Spain; 12Pneumology Service and Faculty of Medicine, Hospital Clínico San Carlos, Complutense University of Madrid, Madrid, Spain; 13Pneumology Service, Hospital Arnau de Vilanova, Valencia, Spain; 14Pneumology Service, Son Espases University Hospital, IdISBa, CIBERES, Clínica Quirón-Rotger, Palma, SpainCorrespondence: Borja G CosioPneumology Service, Hospital Universitario Son Espases, IdISBa, CIBERES, Clínica Quirón-Rotger, Ctra. de Valldemossa 79, Palma de Mallorca 07010, SpainTel +34 871 206714 Ext 76714Fax +34 871 909724Email borja.cosio@ssib.esAbstract: Chronic airflow obstruction affects a wide range of airway diseases, the most frequent of which are asthma, COPD, and bronchiectasis; they are clearly identifiable in their extremes, but quite frequently overlap in some of their pathophysiological and clinical characteristics. This has generated the description of new mixed or overlapping disease phenotypes with no clear biological grounds. In this special article, a group of experts provides their perspective and proposes approaching the treatment of chronic airway disease (CAD) through the identification of a series of therapeutic goals (TG) linked to treatable traits (TT) – understood as clinical, physiological, or biological characteristics that are quantifiable using biomarkers. This therapeutic approach needs validating in a clinical trial with the strategy of identification of TG and treatment according to TT for each patient independently of their prior diagnosis.Keywords: airflow obstruction, biomarker, personalised medicine, COPD asthma overlap
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- 2020
8. Telomere length dynamics over 10-years and related outcomes in patients with COPD
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Córdoba-Lanús, E., Cazorla-Rivero, S., García-Bello, M. A., Mayato, D., Gonzalvo, F., Ayra-Plasencia, J., Celli, B., and Casanova, C.
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- 2021
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9. Desert locust detection using Earth observation satellite data in Mauritania
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Gómez, D., Salvador, P., Sanz, J., Casanova, C., Taratiel, D., and Casanova, J.L.
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- 2019
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10. EP02.31: BiometryAssist® versus manual approach for fetal biometry: correlation, level of agreement and comparison of acquisition time
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Rolle, V., primary, Garcia‐Gonzalez, C., additional, Casanova, C., additional, Fernandez‐Buhigas, I., additional, Santacruz, B., additional, and Gil, M., additional
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- 2023
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11. Selection and breeding of tomato for organic conditions
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Prohens, J. T., Soler, S., Tripodi, P., Campanelli, G., Sestili, S., Figàs, M. R., Casanova, C., Fonseca, R., Hascöet, E., Turner, M., Treccarichi, S., Platani, C., Palma, D., Soler, E., Pereira-Dias, L., Burguet, R., Hamon, C., Díez, M. J., Lozano, R., Branca, F., and Cardi, T.
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hybrids ,landraces ,breeding ,organic systems ,breeding, hybrids, landraces, organic systems, resilience ,Horticulture ,resilience - Abstract
A wide diversity was found in the materials for most traits. Most of the cultivated tomato materials of the CC and BS were also genotyped using the high-throughput ddRAD sequencing technique revealing a high genetic diversity in the collection and allowing the detection of candidate genes and associations for relevant traits under organic conditions. The screening of BS for several diseases (Phytophthora, Fusarium, TSWV, ToMV) has allowed the identification of new sources of tolerance and resistance. A Selected Set of materials has been screened both in Italy and in Spain under control, drought and low N fertilization conditions, and resilient materials under these conditions have been identified. Hybrids obtained between selected materials has allowed the identification of promising hybrids heterotic for yield and with high fruit quality. In addition, several backcross programmes have been undertaken in order to introduce resistance to several diseases, and advanced backcrosses with introgressed resistances have been obtained. New intraspecific and interspecific hybrids have been developed and tested as rootstocks. Some of them outperformed control rootstocks commonly used for grafting tomato. The new improved tomato materials specifically selected for organic conditions can have a dramatic impact in the production of organically grown tomato.
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- 2023
12. 23P Pre-treatment inflammatory indexes predict the clinical outcome of patients with endometrial cancer: A MITO24 study
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Farolfi, A., primary, Scarpi, E., additional, Loizzi, V., additional, Cioffi, R., additional, Tuninetti, V., additional, Valabrega, G., additional, Godina, C., additional, Casanova, C., additional, Ventriglia, J., additional, Arezzo, F., additional, Pignata, S., additional, Candotti, G., additional, Cormio, G., additional, and De Giorgi, U.F.F., additional
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- 2023
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13. 53P Impact of the time interval between primary or interval surgery and adjuvant chemotherapy in ovarian cancer patients
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Farolfi, A., primary, Petracci, E., additional, Gurioli, G., additional, Tedaldi, G., additional, Casanova, C., additional, Arcangeli, V., additional, Rosati, M., additional, Burgio, S.L., additional, Cursano, M.C., additional, Lolli, C., additional, Schepisi, G., additional, and De Giorgi, U.F.F., additional
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- 2023
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14. North Atlantic oscillation influence and weather types associated with winter total and extreme precipitation events in Spain
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Queralt, S., Barriopedro Cepero, David, Hernández, E., Gallego, D., Ribera, P., Casanova, C., Queralt, S., Barriopedro Cepero, David, Hernández, E., Gallego, D., Ribera, P., and Casanova, C.
- Abstract
© 2009 Elsevier B.V. General Assembly of the European-Geosciences-Union (2006. Vienna). The authors wish to thank Universidad Complutense de Madrid and Ministerio de Educación y Ciencia for the grant and contract, respectively, associated to the CG04-05187- CO3-01/CLI project. The authors also want to thank Agencia Estatal de Meteorología (AEMET) for supplying precipitation data. Two anonymous reviewers provided useful comments that helped to improve significantly this manuscript., An analysis of winter intensity and frequency of precipitation is presented, based on 102 daily precipitation stations over Spain and the Balearic Islands for the 1997-2006 decade. Precipitation stations have been merged in the eight different regions which compose the analyzed area by the use of an EOF analysis. NAO influence on the intensity and frequency of precipitation of each region is described in terms of mean precipitation, mean rain frequency, the number of extreme events, changes in the precipitation distribution and the prevalent synoptic configuration. Results indicate a non-stationary response; NAO signal being more evident in mid-late winter. Strong regional differences in the response to NAO are also found, which vary according to the specific character of the precipitation under analysis. Thus, NAO exerts a clear effect on the intensity of total and extreme precipitation rates in northern and westernmost Spanish regions, whereas the frequency of precipitation is clearly affected by NAO in central and southwestern areas. While the correlation between NAO and precipitation is negative for most of the analyzed area, two regions reveal positive responses to NAO in total precipitation occurrence and intensity for specific months. Further analyses reveal asymmetric responses to opposite phases of NAO in the precipitation distributions of some regions. The complex regional relationship between NAO and precipitation is also revealed through the modulation of the former in the preferred Circulation Weather Types associated to precipitation in each region. This spatially non-homogeneous NAO signal stresses the need of caution when employing Iberian precipitation as a proxy for NAO., Universidad Complutense de Madrid, Ministerio de Educación y Ciencia, Depto. de Física de la Tierra y Astrofísica, Fac. de Ciencias Físicas, TRUE, pub
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- 2023
15. Non-pharmacological treatment for neuropathic pain in children with cancer
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Casanova, C., Lerma Lara, S., Pérez Ruiz, M., Ruano Domínguez, D., and Santana Sosa, E.
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- 2015
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16. Distribution and Morphology of Cortical Terminals in the Cat Thalamus from the Anterior Ectosylvian Sulcus
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Huppé-Gourgues, F., Abbas Farishta, R., Boire, D., Ptito, M., and Casanova, C.
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- 2019
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17. Agreement between a simple dyspnea-guided treatment algorithm for stable COPD and the GOLD guidelines: a pilot study
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Cabrera C, Casanova C, Martín Y, Mirabal V, Sánchez MC, Álvarez F, Juliá G, Cabrera-Navarro P, García-Bello MA, Marín JM, de-Torres JP, Divo M, and Celli B
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COPD ,Treatment ,algorithm ,Diseases of the respiratory system ,RC705-779 - Abstract
Carlos Cabrera,1 Ciro Casanova,2 Yolanda Martín,3 Virginia Mirabal,3 María del Carmen Sánchez,4 Felisa Álvarez,5 Gabriel Juliá,1 Pedro Cabrera-Navarro,1 Miguel Ángel García-Bello,6 José María Marín,7 Juan Pablo de-Torres,8 Miguel Divo,9 Bartolomé Celli9 1University Hospital of Gran Canaria Dr Negrín, Respiratory Service, Las Palmas de Gran Canaria, Spain; 2University Hospital Nuestra Señora de la Candelaria, Respiratory Service, Santa Cruz de Tenerife, Spain; 3Arucas Health Center, Primary Care Las Palmas de Gran Canaria, Spain; 4Cueva Torres Health Center, Primary Care Las Palmas de Gran Canaria, Spain; 5La Feria Health Center, Primary Care Las Palmas de Gran Canaria, Spain; 6University Hospital of Gran Canaria Dr Negrín, Investigation Unit, Las Palmas de Gran Canaria, Spain; 7University Hospital Miguel Servet, Respiratory Service, Zaragoza, Spain; 8Navarra University Clinic, Respiratory Service, Pamplona, Spain; 9Brigham and Women’s Hospital, Pulmonary and Critical Care Service, Boston, MA, USA Introduction: Guidelines recommendations for the treatment of COPD are poorly followed. This could be related to the complexity of classification and treatment algorithms. The purpose of this study was to validate a simpler dyspnea-based treatment algorithm for inhaled pharmacotherapy in stable COPD, comparing its concordance with the current Global Initiative for Obstructive Lung Disease (GOLD) guideline.Methods: We enrolled patients who had been diagnosed with COPD in three primary care facilities and two tertiary hospitals in Spain. We determined anthropometric data, forced expiratory volume in the 1st second (percent), exacerbations, and dyspnea based on the modified Medical Research Council scale. We evaluated the new algorithm based on dyspnea and exacerbations and calculated the concordance with the current GOLD recommendations.Results: We enrolled 100 patients in primary care and 150 attending specialized care in a respiratory clinic. There were differences in the sample distribution between cohorts with 41% vs 26% in grade A, 16% vs 12% in grade B, 16% vs 22% in grade C, and 27% vs 40% in grade D for primary and respiratory care, respectively (P=0.005). The coincidence of the algorithm with the GOLD recommendations in primary care was 93% and 91.8% in the respiratory care cohort.Conclusion: A simple dyspnea-based treatment algorithm for inhaled pharmacotherapy of COPD could be useful in the management of COPD patients and concurs very well with the recommended schema suggested by the GOLD initiative. Keywords: COPD, treatment, algorithm, primary care
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- 2016
18. Determination of the total and bioaccessible contents of essential and potentially toxic elements in ayurvedic formulations purchased from different commercial channels
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Giacomino, A., Abollino, Ornella, Casanova, C., La Gioia, C., Magi, E., and Malandrino, M.
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- 2015
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19. Selection and breeding of tomato for organic conditions
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Prohens, J.T., primary, Soler, S., additional, Tripodi, P., additional, Campanelli, G., additional, Sestili, S., additional, Figàs, M.R., additional, Casanova, C., additional, Fonseca, R., additional, Hascöet, E., additional, Turner, M., additional, Treccarichi, S., additional, Platani, C., additional, Palma, D., additional, Soler, E., additional, Pereira-Dias, L., additional, Burguet, R., additional, Hamon, C., additional, Díez, M.J., additional, Lozano, R., additional, Branca, F., additional, and Cardi, T., additional
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- 2022
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20. What pulmonologists think about the asthma–COPD overlap syndrome
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Miravitlles M, Alcázar B, Alvarez FJ, Bazús T, Calle M, Casanova C, Cisneros C, de-Torres JP, Entrenas LM, Esteban C, García-Sidro P, Cosio BG, Huerta A, Iriberri M, Izquierdo JL, López-Viña A, López-Campos JL, Martínez-Moragón E, Pérez de Llano L, Perpiñá M, Ros JA, Serrano J, Soler-Cataluña JJ, Torrego A, Urrutia I, and Plaza V
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Diseases of the respiratory system ,RC705-779 - Abstract
Marc Miravitlles,1,2 Bernardino Alcázar,3 Francisco Javier Alvarez,4 Teresa Bazús,5 Myriam Calle,6 Ciro Casanova,7 Carolina Cisneros,8 Juan P de-Torres,9 Luis M Entrenas,10 Cristóbal Esteban,11 Patricia García-Sidro,12 Borja G Cosio,13 Arturo Huerta,14 Milagros Iriberri,15 José Luis Izquierdo,16 Antolín López-Viña,17 José Luis López-Campos,2,4 Eva Martínez-Moragón,18 Luis Pérez de Llano,19 Miguel Perpiñá,20 José Antonio Ros,21 José Serrano,22 Juan José Soler-Cataluña,23 Alfons Torrego,24 Isabel Urrutia,11 Vicente Plaza24 1Pneumology Department, Hospital Universitari Vall d’Hebron, Barcelona, 2CIBER de Enfermedades Respiratorias (CIBERES), Madrid, 3Respiratory Department, Hospital de Alta Resolucion de Loja, Granada, 4Medical-Surgical Unit of Respiratory Diseases, Virgen del Rocio University Hospital, Biomedicine Institute of Seville (IBiS), Seville, 5Department of Pneumology, Hospital Universitario Central de Asturias, Oviedo, 6Department of Pneumology, Hospital Clínico San Carlos, Madrid, 7Department of Pneumology, Hospital Nuestra Señora de la Candelaria, Santa Cruz de Tenerife, 8Department of Pneumology, Hospital Universitario de La Princesa/Instituto de Investigación Sanitaria (IIS-IP), Madrid, 9Pulmonary Department, Clínica Universidad de Navarra, Pamplona, 10Department of Pneumology, Hospital Universitario Reina Sofia, Córdoba, 11Department of Pneumology, Hospital Galdakao-Usansolo, Galdakao, 12Department of Pneumology, Hospital Universitario de La Plana, Vila-real, 13Department of Pneumology, Hospital Universitario Son Espases IdISPa, Palma de Mallorca, 14Sección Urgencias Medicina – Neumología, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, 15Department of Pneumology, Hospital Universitario de Cruces, Bilbao, 16Department of Pneumology, Hospital Universitario de Guadalajara, Guadalajara, 17Department of Pneumology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, 18Department of Pneumology, Hospital Universitario Dr Peset, Valencia, 19Department of Pneumology, Hospital Universitario Lucus Augusti, Lugo, 20Department of Pneumology, Hospital Universitario y Politécnico La Fe, Valencia, 21Department of Pneumology, Hospital Clínico Universitario Virgen de la Arrinxaca, Murcia, 22Department of Pneumology, Hospital Comarcal de Inca, Inca, 23Pneumology Department, Hospital Arnau de Vilanova-Lliria, Valencia, 24Department of Respiratory Medicine, Hospital de la Santa Creu i Sant Pau, Institut d’Investigació Biomédica Sant Pau (IIB Sant Pau), Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain Background: Some patients with COPD may share characteristics of asthma; this is the so-called asthma–COPD overlap syndrome (ACOS). There are no universally accepted criteria for ACOS, and most treatments for asthma and COPD have not been adequately tested in this population. Materials and methods: We performed a survey among pulmonology specialists in asthma and COPD aimed at collecting their opinions about ACOS and their attitudes in regard to some case scenarios of ACOS patients. The participants answered a structured questionnaire and attended a face-to-face meeting with the Metaplan methodology to discuss different aspects of ACOS. Results: A total of 26 pulmonologists with a mean age of 49.7 years participated in the survey (13 specialists in asthma and 13 in COPD). Among these, 84.6% recognized the existence of ACOS and stated that a mean of 12.6% of their patients might have this syndrome. In addition, 80.8% agreed that the diagnostic criteria for ACOS are not yet well defined. The most frequently mentioned characteristics of ACOS were a history of asthma (88.5%), significant smoking exposure (73.1%), and postbronchodilator forced expiratory volume in 1 second/forced vital capacity
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- 2015
21. Induction TPF followed by concomitant treatment versus concomitant treatment alone in locally advanced head and neck cancer. A phase II–III trial
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Ghi, M. G., Paccagnella, A., Ferrari, D., Foa, P., Alterio, D., Codecà, C., Nolè, F., Verri, E., Orecchia, R., Morelli, F., Parisi, S., Mastromauro, C., Mione, C. A., Rossetto, C., Polsinelli, M., Koussis, H., Loreggian, L., Bonetti, A., Campostrini, F., Azzarello, G., D’Ambrosio, C., Bertoni, F., Casanova, C., Emiliani, E., Guaraldi, M., Bunkheila, F., Bidoli, P., Niespolo, R. M., Gava, A., Massa, E., Frattegiani, A., Valduga, F., Pieri, G., Cipani, T., Da Corte, D., Chiappa, F., and Rulli, E.
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- 2017
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22. Neural Processing of Second-Order Motion in the Suprasylvian Cortex of the Cat
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Bussières, L. and Casanova, C.
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- 2017
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23. Abnormal cortical processing of pattern motion in amblyopia: Evidence from fMRI
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Thompson, B., Villeneuve, M.Y., Casanova, C., and Hess, R.F.
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- 2012
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24. Assessing the impact of hunting pressure on population structure of Guinea baboons (Papio papio) in Guinea-Bissau
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Ferreira da Silva, M. J., Godinho, R., Casanova, C., Minhós, T., Sá, R., and Bruford, M. W.
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- 2014
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25. Chest CT-assessed comorbidities and all-cause mortality risk in COPD patients in the BODE cohort
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Ezponda, A. (Ana), Casanova, C. (Ciro), Divo, M. (Miguel), Marín-Oto, M. (Marta), Marin, J.M. (José M.), Bastarrika, G. (Gorka), Pinto-Plata, V. (Víctor), Martin-Palmero, A. (Ángela), Polverino, F. (Francesca), Celli, B.R. (Bartolomé R.), and Torres, J.P. (Juan P.) de
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Chest CT ,COPD ,Comorbidity ,All-cause mortality ,Tomography - Abstract
Background and objective: The availability of chest computed tomography (CT) imaging can help diagnose comorbidities associated with chronic obstructive pulmonary disease (COPD). Their systematic identification and relationship with allcause mortality have not been explored. Furthermore, whether their CT-detected prevalence differs from clinical diagnosis is unknown. Methods: The prevalence of 10 CT-assessed comorbidities was retrospectively determined at baseline in 379 patients (71% men) with mild to severe COPD attending pulmonary clinics. Anthropometrics, smoking history, dyspnoea, lung function, exercise capacity, BODE (BMI, Obstruction, Dyspnoea and Exercise capacity) index and exacerbations rate were recorded. The prevalence of CT-determined comorbidities was compared with that recorded clinically. Over a median of 78 months of observation, the independent association with all-cause mortality was analysed. A ‘CT-comorbidome’ graphically expressed the strength of their association with mortality risk. Results: Coronary artery calcification, emphysema and bronchiectasis were the most prevalent comorbidities (79.8%, 62.7% and 33.9%, respectively). All were underdiagnosed before CT. Coronary artery calcium (hazard ratio [HR] 2.09; 95% CI 1.03–4.26, p = 0.042), bronchiectasis (HR 2.12; 95% CI 1.05–4.26, p = 0.036) and low psoas muscle density (HR 2.61; 95% CI 1.23–5.57, p = 0.010) were independently associated with all-cause mortality and helped define the ‘CT-comorbidome’. Conclusion: This study of COPD patients shows that systematic detection of 10 CT-diagnosed comorbidities, most of which were not detected clinically, provides information of potential use to patients and clinicians caring for them.
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- 2022
26. Spanish COPD Guidelines (GesEPOC) 2021 Update Diagnosis and Treatment of COPD Exacerbation Syndrome
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Soler-Cataluña JJ, Piñera P, Trigueros JA, Calle M, Casanova C, Cosío BG, López-Campos JL, Molina J, Almagro P, Gómez JT, Riesco JA, Simonet P, Rigau D, Soriano JB, Ancochea J, and Miravitlles M
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This article details the GesEPOC 2021 recommendations on the diagnosis and treatment of COPD exacerbation syndrome (CES). The guidelines propose a definition-based syndromic approach, a new classification of severity, and the recognition of different treatable traits (TT), representing a new step toward personalized medicine. The evidence is evaluated using GRADE methodology, with the incorporation of 6 new PICO questions. The diagnostic process comprises four stages: 1) establish a diagnosis of CES, 2) assess the severity of the episode, 3) identify the trigger, and 4) address TTs. This diagnostic process differentiates an outpatient approach, that recommends the inclusion of a basic battery of tests, from a more comprehensive hospital approach, that includes the study of different biomarkers and imaging tests. Bronchodilator treatment for immediate relief of symptoms is considered essential for all patients, while the use of antibiotics, systemic corticosteroids, oxygen therapy, and assisted ventilation and the treatment of comorbidities will vary depending on severity and possible TTs. The use of antibiotics will be indicated particularly if sputum color changes, when ventilatory assistance is required, in cases involving pneumonia, and in patients with elevated C-reactive protein (>= 20 mg/L). Systemic corticosteroids are recommended in CES that requires admission and are suggested in moderate CES. These drugs are more effective in patients with blood eosinophil counts >= 300 cells/mm(3). Acute-phase non-invasive mechanical ventilation is specified primarily for patients with CES who develop respiratory acidosis despite initial treatment. (C) 2021 SEPAR. Published by Elsevier Espana, S.L.U. All rights reserved.
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- 2022
27. Spanish COPD Guidelines (GesEPOC) 2021: Updated Pharmacological treatment of stable COPD
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Miravitlles M, Calle M, Molina J, Almagro P, Gómez JT, Trigueros JA, Cosío BG, Casanova C, López-Campos JL, Riesco JA, Simonet P, Rigau D, Soriano JB, Ancochea J, and Soler-Cataluña JJ
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respiratory tract diseases - Abstract
The Spanish COPD Guidelines (GesEPOC) were first published in 2012, and since then have undergone a series of updates incorporating new evidence on the diagnosis and treatment of COPD. GesEPOC was drawn up in partnership with scientific societies involved in the treatment of COPD and the Spanish Patients' Forum. Their recommendations are based on an evaluation of the evidence using GRADE methodology, and a narrative description of the evidence in areas in which GRADE cannot be applied. In this article, we summarize the recommendations on the pharmacological treatment of stable COPD based on 9 PICO questions. COPD treatment is a 4-step process: 1) diagnosis, 2) determination of the risk level, 3) initial and subsequent inhaled therapy, and 4) identification and management of treatable traits. For the selection of inhaled therapy, high-risk patients are divided into 3 phenotypes: non-exacerbator, eosinophilic exacerbator, and non-eosinophilic exacerbator. Some treatable traits are general and should be investigated in all patients, such as smoking or inhalation technique, while others affect severe patients in particular, such as chronic hypoxemia and chronic bronchial infection. COPD treatment is based on long-acting bronchodilators with single agents or in combination, depending on the patient's risk level. Eosinophilic exacerbators must receive inhaled corticosteroids, while non-eosinophilic exacerbators require a more detailed evaluation to choose the best therapeutic option. The new GesEPOC also includes recommendations on the withdrawal of inhaled corticosteroids and on indications for alpha-1 antitrypsin treatment. GesEPOC offers a more individualized approach to COPD treatment tailored according to the clinical characteristics of patients and their level of complexity. (c) 2021 SEPAR. Published by Elsevier Espana, S.L.U. All rights reserved.
- Published
- 2022
28. Can the Visits of Dogs (Canis lupus familiaris) Influence the Mental Health (Anxiety and Depression) of Male Aging Patients Institutionalized with Dementia in Health Care Units? A Pilot Study of Madeira Island, Portugal
- Author
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Vasconcelos, S., Azevedo, J., Casanova, C., Jardim, H., Neto, D., Jardim, S., and Viegas, C.
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Animal-Assisted Therapy ,male ,dog ,depression ,pets ,anxiety ,dementia - Abstract
Despite the fact that in the last decades, several mental health studies have shown that companion animals contribute to psychological and social well- being in humans (e.g., positive impacts have been observed in the elderly medicated for chronic diseases such as anxiety, dementia, and depression), bonds between humans and other animals continue to be under-estimated. The aim of this study is to assess the impact of an animal’s visits (twice a week, N = 30) in depression and anxiety levels of an institutionalized male population diagnosed with dementia. While some of these patients are being partially medicated with antidepressants and/or anxiolytics, others are not subject to any medication (control group). The GAI and GDS measuring instruments were used and there were differences in anxiety and depression levels between the first and last dog visit, statistically significant in depression levels of nonmedicated patients. Such findings allow us to conclude that the effects of the visits of an animal near nonmedicated patients are greater than near medicated ones. The complementary role of animals in mental health institutions where patients are being treated for psychiatric disorders (in the particular case of dementia) should be considered.
- Published
- 2021
29. Natural Course of the Diffusing Capacity of the Lungs for Carbon Monoxide in COPD: Importance of Sex
- Author
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Casanova, C, Gonzalez-Davila, E, Martinez-Gonzalez, C, Cosio, BG, Fuster, A, Feu, N, Solanes, I, Cabrera, C, Marin, JM, Balcells, E, Peces-Barba, G, de Torres, JP, Marin-Oto, M, Calle, M, Golpe, R, Ojeda, E, Divo, M, Pinto-Plata, V, Amado, C, Lopez-Campos, JL, Celli, BR, AstraZeneca, and Sociedad Española de Neumología y Cirugía Torácica
- Subjects
Male ,Diffusing capacity of the lungs for carbon monoxide ,Carbon Monoxide ,Smokers ,Lung function decline ,respiratory system ,Respiratory Function Tests ,respiratory tract diseases ,Pulmonary Disease, Chronic Obstructive ,Phenotype ,Sex Factors ,Humans ,Pulmonary Diffusing Capacity ,COPD ,Female ,Sex - Abstract
[Background] The value of the single-breath diffusing capacity of the lungs for carbon monoxide (Dlco) relates to outcomes for patients with COPD. However, little is known about the natural course of Dlco over time, intersubject variability, and factors that may influence Dlco progression., [Research Question] What is the natural course of Dlco in patients with COPD over time, and which other factors, including sex differences, could influence this progression?, [Study Design and Methods] We phenotyped 602 smokers (women, 33%), of whom 506 (84%) had COPD and 96 (16%) had no airflow limitation. Lung function, including Dlco, was monitored annually over 5 years. A random coefficients model was used to evaluate Dlco changes over time., [Results] The mean (± SE) yearly decline in Dlco % in patients with COPD was 1.34% ± 0.015%/y. This was steeper compared with non-COPD control subjects (0.04% ± 0.032%/y; P = .004). Sixteen percent of the patients with COPD, vs 4.3% of the control subjects, had a statistically significant Dlco % slope annual decline (4.14%/y). At baseline, women with COPD had lower Dlco values (11.37% ± 2.27%; P < .001) in spite of a higher FEV1 % than men. Compared with men, women with COPD had a steeper Dlco annual decline of 0.89% ± 0.42%/y (P = .039)., [Interpretation] Patients with COPD have an accelerated decline in Dlco compared with smokers without the disease. However, the decline is slow, and a testing interval of 3 to 4 years may be clinically informative. The lower and more rapid decline in Dlco values in women, compared with men, suggests a differential impact of sex in gas exchange function., [Trial Registry] ClinicalTrials.gov; No.: NCT01122758; URL: www.clinicaltrials.gov, This study was funded in part by an unrestricted grant from AstraZeneca, and also by the COPD Research Program of the Spanish Respiratory Society (PII de EPOC of SEPAR).
- Published
- 2021
30. Contingent screening for preterm pre-eclampsia
- Author
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Wright, D., Gallo, D. M., Pugliese, S. Gil, Casanova, C., and Nicolaides, K. H.
- Published
- 2016
- Full Text
- View/download PDF
31. PREDICTION OF POTENTIAL ANTIOXIDANT DRUGS THROUGH CHEMOMETRIC TECHNIQUES: C092
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Falco Montesinos, A., Casanova, C., Moreno, M. L., García-Domenech, R., Mérida, S., and Villar, V.
- Published
- 2015
32. Bimodal modulation and continuous stimulation in optical imaging to map direction selectivity
- Author
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Vanni, M.P., Provost, J., Casanova, C., and Lesage, F.
- Published
- 2010
- Full Text
- View/download PDF
33. Analysis of the genetic diversity of wild Spanish populations of the genus Hordeum through the study of their endosperm proteins
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De Bustos, A., Casanova, C., Jouve, N., and Soler, C.
- Published
- 1999
34. North Atlantic Oscillation influence and weather types associated with winter total and extreme precipitation events in Spain
- Author
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Queralt, S., Hernández, E., Barriopedro, D., Gallego, D., Ribera, P., and Casanova, C.
- Published
- 2009
- Full Text
- View/download PDF
35. Light-mediated planar polarization of cone photoreceptor cilia contributes to visual acuity in mammals
- Author
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Hojatollah Vali, Filion D, Cortes N, Michel Cayouette, Housset M, Craig A. Mandato, and Casanova C
- Subjects
Retina ,Visual acuity ,genetic structures ,Chemistry ,Cilium ,Cone (formal languages) ,eye diseases ,respiratory tract diseases ,medicine.anatomical_structure ,Mouse Retina ,Planar cell polarity ,medicine ,Basal body ,sense organs ,Transducin ,medicine.symptom ,Neuroscience - Abstract
Planar cell polarity (PCP) is essential to optimize information processing and functional response in many tissues. While the fly eye is a classic example of PCP, it remains unknown whether PCP exists in the mammalian retina and whether it plays a part in vision. Here we used 3D reconstructions of the mouse retina to show that the basal body of cone photoreceptor cilia, but not rods, is systematically located on the side of the cell facing the centre of the retina. We further show that light is required during a critical window of development to establish cone PCP, and that both cone transducin and the G-protein signaling modulator protein 2 are required to mediate this effect. Importantly, we report that disruption of cone PCP impairs visual acuity. This work uncovers a non-canonical PCP pathway, mediated by light, and identifies cone PCP as a feature supporting mammalian vision.
- Published
- 2021
36. Variation for composition and quality in a collection of 'de penjar' long shelf-life tomato under high and low N fertilization levels
- Author
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Rosa-Martínez, E., Adalid,. A.M., Alvarado, L.E., Burguet, R., García-Martínez, M.D., Pereira-Dias, L., Casanova, C., Soler, E., Figàs, M.R., Plazas, M., Prohens, J., and Soler, S.
- Abstract
This article presents the characterization ofr multiple composition traits of 44 accessions of the long-shelf flie "de penjar" tomato.
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- 2021
37. Dynamical processing of orientation precision in the primary visual cortex
- Author
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Ladret Hj, Frédéric Chavane, Ikan L, Casanova C, Cortes N, and Laurent Perrinet
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education.field_of_study ,Orientation (computer vision) ,Computer science ,business.industry ,Bandwidth (signal processing) ,Population ,Message passing ,Pattern recognition ,Visual cortex ,medicine.anatomical_structure ,medicine ,Artificial intelligence ,education ,Representation (mathematics) ,business ,Decoding methods - Abstract
In our daily visual environment, the primary visual cortex (V1) processes distributions of oriented features as the basis of our visual computations. Changes of the global, median orientation of such inputs form the basis of our canonical knowledge about V1. However, another overlooked but defining characteristic of these sensory variables is their precision, which characterizes the level of variance in the input to V1. Such variability is an intrinsic part of natural images, yet it remains unclear if and how V1 accounts for the changes in orientation precision to achieve its robust orientation recognition performances. Here, we used naturalistic stimuli to characterize the response of V1 neurons to quantified variations of orientation precision. We found that about thirty percent of the recorded neurons showed a form of invariant responses to input precision. While feedforward mechanisms failed to account for the existence of these resilient neurons, neuronal competition within V1 explained the extent to which a neuron is invariant to precision. Using a decoding algorithm, we showed that the existence of such neurons in the population response of V1 can serve to encode both the orientation and its precision in the V1 population activity, which improves the robustness of the overall neural code. These precision-specific neurons operate with slow recurrent cortical dynamics, which supports the notion of predictive precisionweighted processes in V1.
- Published
- 2021
38. Prevalence and Determinants of COPD in Spain: EPISCAN II
- Author
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Soriano JB, Alfageme I, Miravitlles M, de Lucas P, Soler-Cataluña JJ, García-Río F, Casanova C, Rodríguez González-Moro JM, Cosío BG, Sánchez G, and Ancochea J
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Spain ,Spirometry ,COPD ,EPISCAN - Abstract
Background: Two previous national epidemiological studies, IBERPOC in 1997 and EPISCAN in 2007, determined the COPD burden in Spain. Changes in demographics and exposure to risk factors demand the periodic update of COPD prevalence and its determinants. Methods: EPISCAN II aimed to estimate the prevalence of COPD in the general population aged 40 years or older in all 17 regions of Spain. A random population screening sample, requiring 600 participants per region performed a questionnaire plus post-bronchodilator (post-BD) spirometry. Results: A total of 12,825 subjects were initially contacted, and 9433 (73.6%) agreed to participate, of whom 9092 performed a valid spirometry. Baseline characteristics were: 52.6% women, mean +/- SD age 60 +/- 11 years, 19.8% current- and 34.2% former-smokers. The prevalence of COPD measured by post-BD fixed ratio FEV1/FVC < 0.7 was 11.8% (95% C.I. 11.2-12.5) with a high variability by region (2.4-fold). Prevalence was 14.6% (95% C.I. 13.5-15.7) in males and 9.4% (95% C.I. 8.6-10.2) in females; according to the lower limit of normal (LLN) was 6.0% (95% C.I. 5.5-6.5) overall, by sex being 7.1% (95% C.I. 6.4-8.0) in males and 4.9% (95% C.I. 4.3-5.6) in females. Underdiagnosis of COPD was 74.7%. Cases with COPD were a mean of seven years older, more frequently male, of lower attained education, and with more smokers than then on COPD population (p < 0.001). However, the number of cigarettes and pack-years in non-COPD participants was substantial, as it was the reported use of e-cigarettes (7.0% vs. 5.5%) (p = 0.045). There were also significant social and clinical differences including living alone, previous respiratory diagnoses, more comorbidities measured with the Charlson index, greater BODE and COTE scores, cognitive impairment, and depression (all p < 0.001). Conclusions: COPD remains prevalent in Spain and frequently underdiagnosed. (C) 2020 SEPAR. Published by Elsevier Espana, S.L.U. All rights reserved.
- Published
- 2021
39. Os babuínos da Guiné (Papio Papio) na Guiné-Bissau : uma revisão bibliográfica para a conservação da espécie
- Author
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Silva, M.J. Ferreira da, Gerini, F., Teixeira, H., Costa, S., and Casanova, C.
- Subjects
CONSERVAÇÃO DAS ESPÉCIES ,GUINÉ-BISSAU ,GUINEA BISSAU ,PRIMATES ,PRIMATAS - Published
- 2021
40. Adjuvant anastrozole versus exemestane versus letrozole, upfront or after 2 years of tamoxifen, in endocrine-sensitive breast cancer (FATA-GIM3): a randomised, phase 3 trial
- Author
-
De Placido, S, Gallo, C, De Laurentiis, M, Bisagni, G, Arpino, G, Sarobba, M, Riccardi, F, Russo, A, Del Mastro, L, Cogoni, A, Cognetti, F, Gori, S, Foglietta, J, Frassoldati, A, Amoroso, D, Laudadio, L, Moscetti, L, Montemurro, F, Verusio, C, Bernardo, A, Lorusso, V, Gravina, A, Moretti, G, Lauria, R, Lai, A, Mocerino, C, Rizzo, S, Nuzzo, F, Carlini, P, Perrone, F, Accurso, A, Agostara, B, Aieta, M, Alabiso, O, Alicicco, M, Amadori, D, Amaducci, L, Amiconi, G, Antuzzi, G, Ardine, M, Ardizzoia, A, Aversa, C, Badalamenti, G, Barni, S, Basurto, C, Berardi, R, Bergamasco, C, Bidoli, P, Bighin, C, Biondi, E, Boni, C, Borgonovo, K, Botta, M, Bravi, S, Bruzzi, P, Buono, G, Butera, A, Caldara, A, Candeloro, G, Cappelletti, C, Cardalesi, C, Carfora, E, Cariello, A, Carrozza, F, Carteni, G, Caruso, M, Casadei, V, Casanova, C, Castori, L, Cavanna, L, Cavazzini, G, Cazzaniga, M, Chilelli, M, Chiodini, P, Chiorrini, S, Ciardiello, F, Ciccarese, M, Cinieri, S, Clerico, M, Coccaro, M, Comande, M, Corbo, C, Cortino, G, Cusenza, S, Daniele, G, D'Arco, A, D'Auria, G, Dazzi, C, De Angelis, C, de Braud, F, De Feo, G, De Matteis, A, De Tursi, M, Di Blasio, A, di Lucca, G, Di Lullo, L, Di Rella, F, Di Renzo, G, Di Stefano, P, Di Stefano, A, Diana, A, Donati, S, Fabbri, A, Fabi, A, Faedi, M, Farina, G, Farris, A, Febbraro, A, Fedele, P, Federico, P, Ferrau, F, Ferretti, G, Ferro, A, Floriani, I, Forcignano, R, Forciniti, S, Forestieri, V, Fornari, G, Frisinghelli, M, Fusco, V, Gallizzi, G, Galvano, A, Gambardella, A, Gambi, A, Gebbia, V, Gervasi, E, Ghilardi, M, Giacobino, A, Giardina, G, Giotta, F, Giraudi, S, Giuliano, M, Grassadonia, A, Grasso, D, Grosso, F, Guizzaro, L, Incoronato, P, Incorvaia, L, Iodice, G, La Verde, N, Labonia, V, Landi, G, Latorre, A, Leonardi, V, Levaggi, A, Limite, G, Lina Bascialla, L, Livi, L, Maiello, E, Mandelli, D, Marcon, I, Menon, D, Montedoro, M, Moraca, L, Moretti, A, Morritti, M, Morselli, P, Mura, A, Mura, S, Musacchio, M, Muzio, A, Natale, D, Natoli, C, Nigro, C, Nistico, C, Nuzzo, A, Orditura, M, Orlando, L, Pacilio, C, Palumbo, G, Palumbo, R, Pasini, F, Paterno, E, Pazzola, A, Pelliccioni, S, Pensabene, M, Perroni, D, Pesenti Gritti, A, Petrelli, F, Piccirillo, M, Pinotti, G, Pogliani, C, Poli, D, Prader, S, Recchia, F, Rizzi, D, Romano, C, Rossello, R, Rossini, C, Salvucci, G, Sanna, V, Santini, A, Saracchini, S, Savastano, C, Scambia, G, Schettini, F, Schiavone, P, Schirone, A, Seles, E, Signoriello, S, Signoriello, G, Silva, R, Silvestri, A, Simeon, V, Spagnoletti, I, Tamberi, S, Teragni, C, Thalmann, V, Thomas, R, Thomas, G, Tienghi, A, Tinari, N, Tinessa, V, Tomei, F, Tonini, G, Torri, V, Traficante, D, Tudini, M, Turazza, M, Vignoli, R, Vitale, M, Zacchia, A, Zagarese, P, Zanni, A, Zavallone, L, Zavettieri, M, Zoboli, A, De Placido S., Gallo C., De Laurentiis M., Bisagni G., Arpino G., Sarobba M. G., Riccardi F., Russo A., Del Mastro L., Cogoni A. A., Cognetti F., Gori S., Foglietta J., Frassoldati A., Amoroso D., Laudadio L., Moscetti L., Montemurro F., Verusio C., Bernardo A., Lorusso V., Gravina A., Moretti G., Lauria R., Lai A., Mocerino C., Rizzo S., Nuzzo F., Carlini P., Perrone F., Accurso A., Agostara B., Aieta M., Alabiso O., Alicicco M. G., Amadori D., Amaducci L., Amiconi G., Antuzzi G., Ardine M., Ardizzoia A., Aversa C., Badalamenti G., Barni S., Basurto C., Berardi R., Bergamasco C., Bidoli P., Bighin C., Biondi E., Boni C., Borgonovo K., Botta M., Bravi S., Bruzzi P., Buono G., Butera A., Caldara A., Candeloro G., Cappelletti C., Cardalesi C., Carfora E., Cariello A., Carrozza F., Carteni G., Caruso M., Casadei V., Casanova C., Castori L., Cavanna L., Cavazzini G., Cazzaniga M., Chilelli M., Chiodini P., Chiorrini S., Ciardiello F., Ciccarese M., Cinieri S., Clerico M., Coccaro M., Comande M., Corbo C., Cortino G., Cusenza S., Daniele G., D'arco A. M., D'auria G., Dazzi C., De Angelis C., de Braud F., De Feo G., De Matteis A., De Tursi M., Di Blasio A., di Lucca G., Di Lullo L., Di Rella F., Di Renzo G., Di Stefano P., Di Stefano A., Diana A., Donati S., Fabbri A., Fabi A., Faedi M., Farina G., Farris A., Febbraro A., Fedele P., Federico P., Ferrau F., Ferretti G., Ferro A., Floriani I., Forcignano R., Forciniti S., Forestieri V., Fornari G., Frisinghelli M., Fusco V., Gallizzi G., Galvano A., Gambardella A., Gambi A., Gebbia V., Gervasi E., Ghilardi M., Giacobino A., Giardina G., Giotta F., Giraudi S., Giuliano M., Grassadonia A., Grasso D., Grosso F., Guizzaro L., Incoronato P., Incorvaia L., Iodice G., La Verde N., Labonia V., Landi G., Latorre A., Leonardi V., Levaggi A., Limite G., Lina Bascialla L., Livi L., Maiello E., Mandelli D., Marcon I., Menon D., Montedoro M., Moraca L., Moretti A., Morritti M. G., Morselli P., Mura A., Mura S., Musacchio M., Muzio A., Natale D., Natoli C., Nigro C., Nistico C., Nuzzo A., Orditura M., Orlando L., Pacilio C., Palumbo G., Palumbo R., Pasini F., Paterno E., Pazzola A., Pelliccioni S., Pensabene M., Perroni D., Pesenti Gritti A., Petrelli F., Piccirillo M. C., Pinotti G., Pogliani C., Poli D., Prader S., Recchia F., Rizzi D., Romano C., Rossello R., Rossini C., Salvucci G., Sanna V., Santini A., Saracchini S., Savastano C., Scambia G., Schettini F., Schiavone P., Schirone A., Seles E., Signoriello S., Signoriello G., Silva R. R., Silvestri A., Simeon V., Spagnoletti I., Tamberi S., Teragni C., Thalmann V., Thomas R., Thomas G., Tienghi A., Tinari N., Tinessa V., Tomei F., Tonini G., Torri V., Traficante D., Tudini M., Turazza M., Vignoli R., Vitale M. G., Zacchia A., Zagarese P., Zanni A., Zavallone L., Zavettieri M., Zoboli A., De Placido, S, Gallo, C, De Laurentiis, M, Bisagni, G, Arpino, G, Sarobba, M, Riccardi, F, Russo, A, Del Mastro, L, Cogoni, A, Cognetti, F, Gori, S, Foglietta, J, Frassoldati, A, Amoroso, D, Laudadio, L, Moscetti, L, Montemurro, F, Verusio, C, Bernardo, A, Lorusso, V, Gravina, A, Moretti, G, Lauria, R, Lai, A, Mocerino, C, Rizzo, S, Nuzzo, F, Carlini, P, Perrone, F, Accurso, A, Agostara, B, Aieta, M, Alabiso, O, Alicicco, M, Amadori, D, Amaducci, L, Amiconi, G, Antuzzi, G, Ardine, M, Ardizzoia, A, Aversa, C, Badalamenti, G, Barni, S, Basurto, C, Berardi, R, Bergamasco, C, Bidoli, P, Bighin, C, Biondi, E, Boni, C, Borgonovo, K, Botta, M, Bravi, S, Bruzzi, P, Buono, G, Butera, A, Caldara, A, Candeloro, G, Cappelletti, C, Cardalesi, C, Carfora, E, Cariello, A, Carrozza, F, Carteni, G, Caruso, M, Casadei, V, Casanova, C, Castori, L, Cavanna, L, Cavazzini, G, Cazzaniga, M, Chilelli, M, Chiodini, P, Chiorrini, S, Ciardiello, F, Ciccarese, M, Cinieri, S, Clerico, M, Coccaro, M, Comande, M, Corbo, C, Cortino, G, Cusenza, S, Daniele, G, D'Arco, A, D'Auria, G, Dazzi, C, De Angelis, C, de Braud, F, De Feo, G, De Matteis, A, De Tursi, M, Di Blasio, A, di Lucca, G, Di Lullo, L, Di Rella, F, Di Renzo, G, Di Stefano, P, Di Stefano, A, Diana, A, Donati, S, Fabbri, A, Fabi, A, Faedi, M, Farina, G, Farris, A, Febbraro, A, Fedele, P, Federico, P, Ferrau, F, Ferretti, G, Ferro, A, Floriani, I, Forcignano, R, Forciniti, S, Forestieri, V, Fornari, G, Frisinghelli, M, Fusco, V, Gallizzi, G, Galvano, A, Gambardella, A, Gambi, A, Gebbia, V, Gervasi, E, Ghilardi, M, Giacobino, A, Giardina, G, Giotta, F, Giraudi, S, Giuliano, M, Grassadonia, A, Grasso, D, Grosso, F, Guizzaro, L, Incoronato, P, Incorvaia, L, Iodice, G, La Verde, N, Labonia, V, Landi, G, Latorre, A, Leonardi, V, Levaggi, A, Limite, G, Lina Bascialla, L, Livi, L, Maiello, E, Mandelli, D, Marcon, I, Menon, D, Montedoro, M, Moraca, L, Moretti, A, Morritti, M, Morselli, P, Mura, A, Mura, S, Musacchio, M, Muzio, A, Natale, D, Natoli, C, Nigro, C, Nistico, C, Nuzzo, A, Orditura, M, Orlando, L, Pacilio, C, Palumbo, G, Palumbo, R, Pasini, F, Paterno, E, Pazzola, A, Pelliccioni, S, Pensabene, M, Perroni, D, Pesenti Gritti, A, Petrelli, F, Piccirillo, M, Pinotti, G, Pogliani, C, Poli, D, Prader, S, Recchia, F, Rizzi, D, Romano, C, Rossello, R, Rossini, C, Salvucci, G, Sanna, V, Santini, A, Saracchini, S, Savastano, C, Scambia, G, Schettini, F, Schiavone, P, Schirone, A, Seles, E, Signoriello, S, Signoriello, G, Silva, R, Silvestri, A, Simeon, V, Spagnoletti, I, Tamberi, S, Teragni, C, Thalmann, V, Thomas, R, Thomas, G, Tienghi, A, Tinari, N, Tinessa, V, Tomei, F, Tonini, G, Torri, V, Traficante, D, Tudini, M, Turazza, M, Vignoli, R, Vitale, M, Zacchia, A, Zagarese, P, Zanni, A, Zavallone, L, Zavettieri, M, Zoboli, A, De Placido S., Gallo C., De Laurentiis M., Bisagni G., Arpino G., Sarobba M. G., Riccardi F., Russo A., Del Mastro L., Cogoni A. A., Cognetti F., Gori S., Foglietta J., Frassoldati A., Amoroso D., Laudadio L., Moscetti L., Montemurro F., Verusio C., Bernardo A., Lorusso V., Gravina A., Moretti G., Lauria R., Lai A., Mocerino C., Rizzo S., Nuzzo F., Carlini P., Perrone F., Accurso A., Agostara B., Aieta M., Alabiso O., Alicicco M. G., Amadori D., Amaducci L., Amiconi G., Antuzzi G., Ardine M., Ardizzoia A., Aversa C., Badalamenti G., Barni S., Basurto C., Berardi R., Bergamasco C., Bidoli P., Bighin C., Biondi E., Boni C., Borgonovo K., Botta M., Bravi S., Bruzzi P., Buono G., Butera A., Caldara A., Candeloro G., Cappelletti C., Cardalesi C., Carfora E., Cariello A., Carrozza F., Carteni G., Caruso M., Casadei V., Casanova C., Castori L., Cavanna L., Cavazzini G., Cazzaniga M., Chilelli M., Chiodini P., Chiorrini S., Ciardiello F., Ciccarese M., Cinieri S., Clerico M., Coccaro M., Comande M., Corbo C., Cortino G., Cusenza S., Daniele G., D'arco A. M., D'auria G., Dazzi C., De Angelis C., de Braud F., De Feo G., De Matteis A., De Tursi M., Di Blasio A., di Lucca G., Di Lullo L., Di Rella F., Di Renzo G., Di Stefano P., Di Stefano A., Diana A., Donati S., Fabbri A., Fabi A., Faedi M., Farina G., Farris A., Febbraro A., Fedele P., Federico P., Ferrau F., Ferretti G., Ferro A., Floriani I., Forcignano R., Forciniti S., Forestieri V., Fornari G., Frisinghelli M., Fusco V., Gallizzi G., Galvano A., Gambardella A., Gambi A., Gebbia V., Gervasi E., Ghilardi M., Giacobino A., Giardina G., Giotta F., Giraudi S., Giuliano M., Grassadonia A., Grasso D., Grosso F., Guizzaro L., Incoronato P., Incorvaia L., Iodice G., La Verde N., Labonia V., Landi G., Latorre A., Leonardi V., Levaggi A., Limite G., Lina Bascialla L., Livi L., Maiello E., Mandelli D., Marcon I., Menon D., Montedoro M., Moraca L., Moretti A., Morritti M. G., Morselli P., Mura A., Mura S., Musacchio M., Muzio A., Natale D., Natoli C., Nigro C., Nistico C., Nuzzo A., Orditura M., Orlando L., Pacilio C., Palumbo G., Palumbo R., Pasini F., Paterno E., Pazzola A., Pelliccioni S., Pensabene M., Perroni D., Pesenti Gritti A., Petrelli F., Piccirillo M. C., Pinotti G., Pogliani C., Poli D., Prader S., Recchia F., Rizzi D., Romano C., Rossello R., Rossini C., Salvucci G., Sanna V., Santini A., Saracchini S., Savastano C., Scambia G., Schettini F., Schiavone P., Schirone A., Seles E., Signoriello S., Signoriello G., Silva R. R., Silvestri A., Simeon V., Spagnoletti I., Tamberi S., Teragni C., Thalmann V., Thomas R., Thomas G., Tienghi A., Tinari N., Tinessa V., Tomei F., Tonini G., Torri V., Traficante D., Tudini M., Turazza M., Vignoli R., Vitale M. G., Zacchia A., Zagarese P., Zanni A., Zavallone L., Zavettieri M., and Zoboli A.
- Abstract
Background: Uncertainty exists about the optimal schedule of adjuvant treatment of breast cancer with aromatase inhibitors and, to our knowledge, no trial has directly compared the three aromatase inhibitors anastrozole, exemestane, and letrozole. We investigated the schedule and type of aromatase inhibitors to be used as adjuvant treatment for hormone receptor-positive early breast cancer. Methods: FATA-GIM3 is a multicentre, open-label, randomised, phase 3 trial of six different treatments in postmenopausal women with hormone receptor-positive early breast cancer. Eligible patients had histologically confirmed invasive hormone receptor-positive breast cancer that had been completely removed by surgery, any pathological tumour size, and axillary nodal status. Key exclusion criteria were hormone replacement therapy, recurrent or metastatic disease, previous treatment with tamoxifen, and another malignancy in the previous 10 years. Patients were randomly assigned in an equal ratio to one of six treatment groups: oral anastrozole (1 mg per day), exemestane (25 mg per day), or letrozole (2·5 mg per day) tablets upfront for 5 years (upfront strategy) or oral tamoxifen (20 mg per day) for 2 years followed by oral administration of one of the three aromatase inhibitors for 3 years (switch strategy). Randomisation was done by a computerised minimisation procedure stratified for oestrogen receptor, progesterone receptor, and HER2 status; previous chemotherapy; and pathological nodal status. Neither the patients nor the physicians were masked to treatment allocation. The primary endpoint was disease-free survival. The minimum cutoff to declare superiority of the upfront strategy over the switch strategy was assumed to be a 2% difference in disease-free survival at 5 years. Primary efficacy analyses were done by intention to treat; safety analyses included all patients for whom at least one safety case report form had been completed. Follow-up is ongoing. This trial is regist
- Published
- 2018
41. Innovative social behavior in chimpanzees (Pan troglodytes)
- Author
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Casanova, C., Mondragon-Ceballos, R., and Lee, P.C.
- Subjects
Chimpanzees -- Research ,Chimpanzees -- Social aspects ,Chimpanzees -- Behavior ,Social behavior in animals -- Observations ,Anthropology/archeology/folklore ,Biological sciences ,Health ,Psychology and mental health - Abstract
A study of the agonistic buffering behavior among chimpanzees and the status of the buffers used, either an infant of the alpha female or the social rank of the male, are described. The chimpanzees adapt to new social conditions by changing behavior.
- Published
- 2008
42. [Design and validation of a Male Sexual Function Questionnaire]
- Author
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Sánchez-Sánchez F, Ferrer-Casanova C, Ponce-Buj B, Sipán-Sarrión Y, Jurado-López AR, San Martin-Blanco C, Tijeras-Úbeda MJ, and Pascual Regueiro N
- Subjects
Adult ,Male ,Sexual Dysfunction, Physiological ,Young Adult ,Cross-Sectional Studies ,Adolescent ,Psychometrics ,Surveys and Questionnaires ,Quality of Life ,Humans ,Reproducibility of Results ,Middle Aged ,Aged - Abstract
OBJECTIVE: The objective of this work was to design and validate a questionnaire on Male Sexual Function (MSF) in the Spanish language, following the criteria contemplated in the Diagnostic and Statistical Manual of Mental Disorders, DSM-5, for the diagnosis of sexual dysfunctions. MATERIAL AND METHODS: A cross-sectional and multicentre study was conducted on 163 men (18-70 years) who self-completed a test (MSF questionnaire). They then answered questions on the Structured History of Male Sexual Function (AMSF). Four weeks later they completed a re-test, which was the same, but including a supplementary question about the possible influence of recent events. RESULTS: Internal consistency: Cronbach's alpha test 0.840, AMSF 0.835, retest 0.855. Test-retest reliability: mean test scores 33.13±6.566, retest 33.11±6.791; Student t 0.122, not significant (P=.903); correlation total test-retest scores (intraclass correlation coefficient) 0.979, significant correlation (P90% for all items / domains, sensitivity>80% except item 4 (76%). Content validity: using factor analysis, grouping of items into 4 components (explain 75% variance); high correlation between "sexual desire" and "confidence in erection". CONCLUSIONS: The MSF questionnaire is reliable, stable and valid, with high specificity and sensitivity. It evaluates the sexual response of the male, describing aspects of interest: anticipatory anxiety, initiative, confidence to communicate preferences, events that may influence. Can detect sexual dysfunction in the couple.
- Published
- 2020
43. Phenotypic characterisation of early COPD: a prospective case-control study
- Author
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Cosío BG, Pascual-Guardia S, Borras-Santos A, Peces-Barba G, Santos S, Vigil L, Soler-Cataluña JJ, Martínez-González C, Casanova C, Marcos PJ, Alvarez CJ, López-Campos JL, Gea J, Garcia-Aymerich J, Molina J, Román M, Moises J, Szabo V, Reagan EA, San José Estépar R, Washko G, Agustí A, and Faner R
- Subjects
respiratory tract diseases - Abstract
The phenotypic characteristics of chronic obstructive pulmonary disease (COPD) in individuals younger than 50 years of age (early COPD) are not well defined. This prospective, multi-centre, case-control study sought to describe these characteristics and compare them with those of smokers (>= 10 pack-years) of similar age with normal spirometry (controls). We studied 92 cases (post-bronchodilator forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC)
- Published
- 2020
44. Global motion integration in the postero-medial part of the lateral suprasylvian cortex in the cat
- Author
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Villeneuve, M. Y., Ptito, M., and Casanova, C.
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- 2006
- Full Text
- View/download PDF
45. The influence of soil tillage system on Salsola kali L. emergence during the fallow period within cereal fields
- Author
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Ministerio de Ciencia, Innovación y Universidades (España), Comunidad de Madrid, Santín Montanyá, Inés [0000-0003-1978-6560], Gandía, María Luisa [0000-0002-5671-6011], Tenorio, J. L. [0000-0001-7596-6676], Santín Montanyá, Inés, Gandía, María Luisa, Casanova, C., Sánchez Jiménez, Francisco Javier, Tenorio, J. L., Ministerio de Ciencia, Innovación y Universidades (España), Comunidad de Madrid, Santín Montanyá, Inés [0000-0003-1978-6560], Gandía, María Luisa [0000-0002-5671-6011], Tenorio, J. L. [0000-0001-7596-6676], Santín Montanyá, Inés, Gandía, María Luisa, Casanova, C., Sánchez Jiménez, Francisco Javier, and Tenorio, J. L.
- Abstract
With the move towards conservation agriculture, we have seen an increase in weeds such as Salsola kali L., well known as Russian thistle, which are wind spread over fallow land. The emergence of this weed species seemed erratic, perhaps connected to climate conditions and management techniques. In order to shed some light on this issue, we carried out a field experiment over 3 years to monitor Russian thistle density in fallow plots, comparing three tillage systems. This study provides an insight about the limitations of assuming no-tillage techniques within a cropping system that include fallow in the rotation sequence. Our results show that no-tillage systems are more vulnerable to S. kali. Low spring rain leads to high S. kali density, especially in no-tillage plots. High spring rainfall reduced the emergence in all tillage systems because of soil water saturation. Minimum tillage technique served to maintain control over this species even in weather conditions that favoured its emergence in other systems. In order to reduce the need for herbicide in fallow lands under conservation systems, we recommend the implementation of minimum tillage to combat Russian thistle infestation.
- Published
- 2020
46. Arable weed patterns according to temperature and latitude gradient in central and southern Spain
- Author
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Ministerio de Ciencia e Innovación (España), Ministerio de Transición Ecológica (España), CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Gandía, María Luisa [0000-0002-5671-6011], Sánchez Jiménez, Francisco Javier [0000-0002-4690-9864], Tenorio, J. L. [0000-0001-7596-6676], Santín Montanyá, Inés [0000-0003-1978-6560], Gandía, María Luisa, Casanova, C., Sánchez Jiménez, Francisco Javier, Tenorio, J. L., Santín Montanyá, Inés, Ministerio de Ciencia e Innovación (España), Ministerio de Transición Ecológica (España), CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Gandía, María Luisa [0000-0002-5671-6011], Sánchez Jiménez, Francisco Javier [0000-0002-4690-9864], Tenorio, J. L. [0000-0001-7596-6676], Santín Montanyá, Inés [0000-0003-1978-6560], Gandía, María Luisa, Casanova, C., Sánchez Jiménez, Francisco Javier, Tenorio, J. L., and Santín Montanyá, Inés
- Abstract
(1) Background: In agro-ecosystems, the success of the crops has a strong connection to biodiversity in the landscape. In the face of climate change, it is important to understand the response to environmental variation of weed species by means of their distribution. In the last century, biodiversity has been impacted due to a variety of stresses related to climate change. Although the composition of vegetation tends to change at a slower rate than climate change, we hypothesize species present in weed communities are distributed in diverse patterns as a response to the climate. Therefore, the general aim of this paper is to investigate the effect of temperature, using latitude as an indicator, on the composition and distribution of weed communities in agro-ecosystems. (2) Methods: Weeds were monitored in georeferenced cereal fields which spanned south and central Spanish regions. The graphic representation according to latitude allowed us to identify groups of weeds and associate them to a temperature range. We classified weeds as generalist, regional, or local according to the range of distribution. (3) Results: The monitoring of species led to the classification of weeds as generalist, regional or local species according to latitude and associated temperature ranges. Three weed species that were present in all latitude/temperature regions, were classified as generalist (Linaria micrantha (Cav) Hoffmanns & Link, Sonchus oleraceous L., and Sysimbrium irium L.). The species were classified as regional or local when their presence was limited to restricted latitude/temperature ranges. One weed, Stellaria media (L.) Vill., was considered a local species and its distribution dynamics can be considered an indicator of temperature. (4) Conclusions: The novel methodology used in this study to assign weed distribution as an indicator of climatic conditions could be applied to evaluate climate gradients around the world.
- Published
- 2020
47. Optimal stimulus size maps in the primary visual cortex revealed by optical imaging in cats
- Author
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CASANOVA, C, VANNI, M, and VILLENEUVE, M Y
- Published
- 2007
48. Saturated Heat Capacities of Some Linear and Branched Alkyl-Benzenes Between 288 and 348 K
- Author
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Páramo, R., Zouine, M., Sobrón, F., and Casanova, C.
- Published
- 2003
- Full Text
- View/download PDF
49. Deacidification of paper using dispersions of Ca(OH) 2 nanoparticles in isopropanol. Study of efficiency
- Author
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Sequeira, S., Casanova, C., and Cabrita, E.J.
- Published
- 2006
- Full Text
- View/download PDF
50. Calidad vocal en niños sordos. La influencia del tipo de audífono empleado
- Author
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Valero, J., Gou, J., and Casanova, C.
- Published
- 2006
- Full Text
- View/download PDF
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