Search

Your search keyword '"Casabonne D"' showing total 202 results
Start Over Author "Casabonne D"
202 results on '"Casabonne D"'

1. Infection with Kaposi's sarcoma-associated herpesvirus (KSHV) and human immunodeficiency virus (HIV) in relation to the risk and clinical presentation of Kaposi's sarcoma in Uganda

Author

Newton, R, Ziegler, J, Bourboulia, D, Casabonne, D, Beral, V, Mbidde, E, Carpenter, L, Parkin, DM, Wabinga, H, Mbulaiteye, S, Jaffe, H, Weiss, R, and Boshoff, C

Subjects
Cancer, HIV/AIDS, Emerging Infectious Diseases, Rare Diseases, Infectious Diseases, Pediatric, Aetiology, 2.1 Biological and endogenous factors, Infection, Adolescent, Adult, Antibodies, Viral, Case-Control Studies, Female, HIV Infections, Herpesvirus 8, Human, Humans, Male, Risk Factors, Sarcoma, Kaposi, Seroepidemiologic Studies, Severity of Illness Index, Uganda, Oncology and Carcinogenesis, Public Health and Health Services, Oncology & Carcinogenesis
Abstract

A case-control study from Uganda found that the risk of Kaposi's sarcoma increased with increasing titre of antibodies against Kaposi's sarcoma-associated herpesvirus (KSHV) latent nuclear antigens, independently of HIV infection. Clinically, widespread Kaposi's sarcoma was more frequent among patients with HIV infection than in those without, but was not related to anti-KSHV antibody titres.

Published
2003

2. Do GWAS-Identified Risk Variants for Chronic Lymphocytic Leukemia Influence Overall Patient Survival and Disease Progression?

Author

Cabrera-Serrano, A.J., Sánchez-Maldonado, J.M., Horst, R, Macauda, A., García-Martín, P., Benavente, Y., Landi, S., Clay-Gilmour, A., Niazi, Y., Espinet, B., Rodríguez-Sevilla, J.J., Pérez, E.M., Maffei, R., Blanco, G., Giaccherini, M., Cerhan, J.R., Marasca, R., López-Nevot, M.Á., Chen-Liang, T., Thomsen, H., Gámez, I., Campa, D., Moreno, V., Sanjosé, S. de, Marcos-Gragera, R., García-Álvarez, M., Dierssen-Sotos, T., Jerez, A., Butrym, A., Norman, A.D., Luppi, M., Slager, S.L., Hemminki, K., Li, Y., Berndt, S.I., Casabonne, D., Alcoceba, M., Puiggros, A., Netea, M.G., Försti, A., Canzian, F., Sainz, J., Cabrera-Serrano, A.J., Sánchez-Maldonado, J.M., Horst, R, Macauda, A., García-Martín, P., Benavente, Y., Landi, S., Clay-Gilmour, A., Niazi, Y., Espinet, B., Rodríguez-Sevilla, J.J., Pérez, E.M., Maffei, R., Blanco, G., Giaccherini, M., Cerhan, J.R., Marasca, R., López-Nevot, M.Á., Chen-Liang, T., Thomsen, H., Gámez, I., Campa, D., Moreno, V., Sanjosé, S. de, Marcos-Gragera, R., García-Álvarez, M., Dierssen-Sotos, T., Jerez, A., Butrym, A., Norman, A.D., Luppi, M., Slager, S.L., Hemminki, K., Li, Y., Berndt, S.I., Casabonne, D., Alcoceba, M., Puiggros, A., Netea, M.G., Försti, A., Canzian, F., and Sainz, J.

Abstract

Contains fulltext : 292738.pdf (Publisher’s version ) (Open Access), Chronic lymphocytic leukemia (CLL) is the most common leukemia among adults worldwide. Although genome-wide association studies (GWAS) have uncovered the germline genetic component underlying CLL susceptibility, the potential use of GWAS-identified risk variants to predict disease progression and patient survival remains unexplored. Here, we evaluated whether 41 GWAS-identified risk variants for CLL could influence overall survival (OS) and disease progression, defined as time to first treatment (TTFT) in a cohort of 1039 CLL cases ascertained through the CRuCIAL consortium. Although this is the largest study assessing the effect of GWAS-identified susceptibility variants for CLL on OS, we only found a weak association of ten single nucleotide polymorphisms (SNPs) with OS (p < 0.05) that did not remain significant after correction for multiple testing. In line with these results, polygenic risk scores (PRSs) built with these SNPs in the CRuCIAL cohort showed a modest association with OS and a low capacity to predict patient survival, with an area under the receiver operating characteristic curve (AUROC) of 0.57. Similarly, seven SNPs were associated with TTFT (p < 0.05); however, these did not reach the multiple testing significance threshold, and the meta-analysis with previous published data did not confirm any of the associations. As expected, PRSs built with these SNPs showed reduced accuracy in prediction of disease progression (AUROC = 0.62). These results suggest that susceptibility variants for CLL do not impact overall survival and disease progression in CLL patients.

Published
2023

3. Validation and functional characterization of GWAS-identified variants for chronic lymphocytic leukemia: a CRuCIAL study

Author

García-Martín, P., Díez, A.M., Maldonado, J.M.S., Serrano, A.J.C., Horst, R. ter, Benavente, Y., Landi, S., Macauda, A., Clay-Gilmour, A., Hernández-Mohedo, F., Niazi, Y., González-Sierra, P., Espinet, B., Rodríguez-Sevilla, J.J., Maffei, R., Blanco, G., Giaccherini, M., Puiggros, A., Cerhan, J., Marasca, R., Cañadas-Garre, M., López-Nevot, M., Chen-Liang, T., Thomsen, H., Gámez, I., Moreno, V., Marcos-Gragera, R., García-Álvarez, M., Llorca, J., Jerez, A., Berndt, S., Butrym, A., Norman, A.D., Casabonne, D., Luppi, M., Slager, S.L., Hemminki, K., Li, Y., Alcoceba, M., Campa, D., Canzian, F., Sanjosé, S. de, Försti, A., Netea, M.G., Jurado, M., Sainz, J., García-Martín, P., Díez, A.M., Maldonado, J.M.S., Serrano, A.J.C., Horst, R. ter, Benavente, Y., Landi, S., Macauda, A., Clay-Gilmour, A., Hernández-Mohedo, F., Niazi, Y., González-Sierra, P., Espinet, B., Rodríguez-Sevilla, J.J., Maffei, R., Blanco, G., Giaccherini, M., Puiggros, A., Cerhan, J., Marasca, R., Cañadas-Garre, M., López-Nevot, M., Chen-Liang, T., Thomsen, H., Gámez, I., Moreno, V., Marcos-Gragera, R., García-Álvarez, M., Llorca, J., Jerez, A., Berndt, S., Butrym, A., Norman, A.D., Casabonne, D., Luppi, M., Slager, S.L., Hemminki, K., Li, Y., Alcoceba, M., Campa, D., Canzian, F., Sanjosé, S. de, Försti, A., Netea, M.G., Jurado, M., and Sainz, J.

Abstract

Contains fulltext : 251927.pdf (Publisher’s version ) (Open Access)

Published
2022

4. High-risk subtypes of chronic lymphocytic leukemia are detectable as early as 16 years prior to diagnosis

Author

Kolijn, P.M. Hosnijeh, F.S. Späth, F. Hengeveld, P.J. Agathangelidis, A. Saleh, M. Casabonne, D. Benavente, Y. Jerkeman, M. Agudo, A. Barricarte, A. Besson, C. Sánchez, M.-J. Chirlaque, M.-D. Masala, G. Sacerdote, C. Grioni, S. Schulze, M.B. Nieters, A. Engelfriet, P. Hultdin, M. McKay, J.D. Vermeulen, R.C.H. Langerak, A.W.

Subjects
immune system diseases, hemic and lymphatic diseases
Abstract

Chronic lymphocytic leukemia (CLL) is preceded by monoclonal B-cell lymphocytosis (MBL), a CLL precursor state with a prevalence of up to 12% in aged individuals; however, the duration of MBL and the mechanisms of its evolution to CLL remain largely unknown. In this study, we sequenced the B-cell receptor (BcR) immunoglobulin heavy chain (IGH) gene repertoire of 124 patients with CLL and 118 matched controls in blood samples taken up to 22 years prior to diagnosis. Significant skewing in the BcR IGH gene repertoire was detected in the majority of patients, even before the occurrence of lymphocytosis and irrespective of the clonotypic IGH variable gene somatic hypermutation status. Furthermore, we identified dominant clonotypes belonging to major stereotyped subsets associated with poor prognosis up to 16 years before diagnosis in 14 patients with CLL. In 22 patients with longitudinal samples, the skewing of the BcR IGH gene repertoire increased significantly over time to diagnosis or remained stable at high levels. For 14 of 16 patients with available samples at diagnosis, the CLL clonotype was already present in the prediagnostic samples. Overall, our data indicate that the preclinical phase of CLL could be longer than previously thought, even in adverse-prognostic cases. © 2022 American Society of Hematology

Published
2022

5. Human papillomaviruses and cancer in Uganda

Author

Newton, R, Bousarghin, L, Ziegler, J, Casabonne, D, Beral, V, Mbidde, E, Carpenter, L, Parkin, D M, Wabinga, H, Mbulaiteye, S, Jaffe, H, Touzé, A, and Coursaget, P

Published
2004

6. Effect of time of day of recreational and household physical activity on prostate and breast cancer risk (MCC-Spainstudy)

Author

Weitzer J, Castaño-Vinyals G, Aragonés N, Gómez-Acebo I, Guevara M, Amiano P, Martín V, Molina-Barceló A, Alguacil J, Moreno V, Suarez-Calleja C, Jiménez-Moleón JJ, Marcos-Gragera R, Papantoniou K, Pérez-Gómez B, Llorca J, Ascunce N, Gil L, Gracia-Lavedan E, Casabonne D, Lope V, Pollán M, and Kogevinas M

Subjects
prostate, circadian disruption, cancer, physical activity, breast
Abstract

Experimental evidence indicates that exercise performed at different times of the day may affect circadian rhythms and circadian disruption has been linked to breast and prostate cancer. We examined in a population-based case-control study (MCC-Spain) if the time-of-day when physical activity is done affects prostate and breast cancer risk. Lifetime recreational and household physical activity was assessed by in-person interviews. Information on time-of-day of activity (assessed approximately 3 years after the assessment of lifetime physical activity and confounders) was available for 781 breast cancer cases, 865 population female controls, 504 prostate cases and 645 population male controls from 10 Spanish regions, 2008-2013. We estimated odds ratios (ORs) and 95% confidence intervals (95% CI) for different activity timings compared to inactive subjects using unconditional logistic regression adjusting for confounders. Early morning (8-10am) activity was associated with a protective effect compared to no physical activity for both breast (OR = 0.74, 95% CI = 0.48-1.15) and prostate cancer (OR = 0.73, 95% CI = 0.44-1.20); meta-OR for the two cancers combined 0.74 (95%CI = 0.53-1.02). There was no effect observed for breast or prostate cancer for late morning to afternoon activity while a protective effect was also observed for evening activity only for prostate cancer (OR = 0.75, 95% CI = 0.45-1.24). Protective effects of early morning activity were more pronounced for intermediate/evening chronotypes for both cancers. This is the first population-based investigation identifying a differential effect of timing of physical activity on cancer risk with more pronounced effects for morning hour activity. Our results, if confirmed, may improve current physical activity recommendations for cancer prevention.

Published
2021

7. The Association of Nighttime Fasting Duration and Prostate Cancer Risk: Results from the Multicase-Control (MCC) Study in Spain

Author

Palomar-Cros A, Espinosa A, Straif K, Pérez-Gómez B, Papantoniou K, Gómez-Acebo I, Molina-Barceló A, Olmedo-Requena R, Alguacil J, Fernández-Tardón G, Casabonne D, Aragonés N, Castaño-Vinyals G, Pollán M, Romaguera D, and Kogevinas M

Subjects
early time-restricted feeding, circadian rhythms, chrononutrition, breakfast, prostate cancer, prolonged nighttime fasting
Abstract

Nighttime fasting has been inconclusively associated with a reduced risk of cancer. The purpose of this study was to investigate this association in relation to prostate cancer risk. We examined data from 607 prostate cancer cases and 848 population controls who had never worked in night shift work from the Spanish multicase-control (MCC) study, 2008-2013. Through an interview, we collected circadian information on meal timing at mid-age. We estimated odds ratios (OR) and 95% confidence intervals (CI) with unconditional logistic regression. After controlling for time of breakfast, fasting for more than 11 h overnight (the median duration among controls) was associated with a reduced risk of prostate cancer compared to those fasting for 11 h or less (OR = 0.77, 95% 0.54-1.07). Combining a long nighttime fasting and an early breakfast was associated with a lower risk of prostate cancer compared to a short nighttime fasting and a late breakfast (OR = 0.54, 95% CI 0.27-1.04). This study suggests that a prolonged nighttime fasting duration and an early breakfast may be associated with a lower risk of prostate cancer. Findings should be interpreted cautiously and add to growing evidence on the importance of chrononutrition in relation to cancer risk.

Published
2021

8. Association between anthropometry and lifestyle factors and risk of B-cell lymphoma: An exposome-wide analysis

Author

Saberi Hosnijeh, F, Casabonne, D, Nieters, A, Solans, M, Naudin, S, Ferrari, P, Mckay, JD, Benavente, Y, Weiderpass, E, Freisling, H, Severi, G, Boutron Ruault, M-C, Besson, C, Agnoli, C, Masala, G, Sacerdote, C, Tumino, R, Huerta, JM, Amiano, P, Rodriguez-Barranco, M, Bonet, C, Barricarte, A, Christakoudi, S, Knuppel, A, Bueno-de-Mesquita, B, Schulze, MB, Kaaks, R, Canzian, F, Spath, F, Jerkeman, M, Rylander, C, Tjonneland, A, Olsen, A, Borch, KB, Vermeulen, R, Saberi Hosnijeh, F, Casabonne, D, Nieters, A, Solans, M, Naudin, S, Ferrari, P, Mckay, JD, Benavente, Y, Weiderpass, E, Freisling, H, Severi, G, Boutron Ruault, M-C, Besson, C, Agnoli, C, Masala, G, Sacerdote, C, Tumino, R, Huerta, JM, Amiano, P, Rodriguez-Barranco, M, Bonet, C, Barricarte, A, Christakoudi, S, Knuppel, A, Bueno-de-Mesquita, B, Schulze, MB, Kaaks, R, Canzian, F, Spath, F, Jerkeman, M, Rylander, C, Tjonneland, A, Olsen, A, Borch, KB, and Vermeulen, R

Abstract

To better understand the role of individual and lifestyle factors in human disease, an exposome-wide association study was performed to investigate within a single-study anthropometry measures and lifestyle factors previously associated with B-cell lymphoma (BCL). Within the European Prospective Investigation into Cancer and nutrition study, 2402 incident BCL cases were diagnosed from 475 426 participants that were followed-up on average 14 years. Standard and penalized Cox regression models as well as principal component analysis (PCA) were used to evaluate 84 exposures in relation to BCL risk. Standard and penalized Cox regression models showed a positive association between anthropometric measures and BCL and multiple myeloma/plasma cell neoplasm (MM). The penalized Cox models additionally showed the association between several exposures from categories of physical activity, smoking status, medical history, socioeconomic position, diet and BCL and/or the subtypes. PCAs confirmed the individual associations but also showed additional observations. The PC5 including anthropometry, was positively associated with BCL, diffuse large B-cell lymphoma (DLBCL) and MM. There was a significant positive association between consumption of sugar and confectionary (PC11) and follicular lymphoma risk, and an inverse association between fish and shellfish and Vitamin D (PC15) and DLBCL risk. The PC1 including features of the Mediterranean diet and diet with lower inflammatory score showed an inverse association with BCL risk, while the PC7, including dairy, was positively associated with BCL and DLBCL risk. Physical activity (PC10) was positively associated with DLBCL risk among women. This study provided informative insights on the etiology of BCL.

Published
2021

9. Mediating effect of soluble B-cell activation immune markers on the association between anthropometric and lifestyle factors and lymphoma development

Author

Saberi Hosnijeh, F. Kolijn, P.M. Casabonne, D. Nieters, A. Solans, M. Naudin, S. Ferrari, P. Mckay, J.D. Weiderpass, E. Perduca, V. Besson, C. Mancini, F.R. Masala, G. Krogh, V. Ricceri, F. Huerta, J.M. Petrova, D. Sala, N. Trichopoulou, A. Karakatsani, A. La Vecchia, C. Kaaks, R. Canzian, F. Aune, D. Boeing, H. Schulze, M.B. Perez-Cornago, A. Langerak, A.W. van der Velden, V.H.J. Vermeulen, R.

Subjects
immune system diseases, hemic and lymphatic diseases
Abstract

Sustained B-cell activation is an important mechanism contributing to B-cell lymphoma (BCL). We aimed to validate four previously reported B-cell activation markers predictive of BCL risk (sCD23, sCD27, sCD30, and CXCL13) and to examine their possible mediating effects on the association between anthropometric and lifestyle factors and major BCL subtypes. Pre-diagnostic serum levels were measured for 517 BCL cases and 525 controls in a nested case–control study. The odds ratios of BCL were 6.2 in the highest versus lowest quartile for sCD23, 2.6 for sCD30, 4.2 for sCD27, and 2.6 for CXCL13. Higher levels of all markers were associated with increased risk of chronic lymphocytic leukemia (CLL), follicular lymphoma (FL), and diffuse large B-cell lymphoma (DLBCL). Following mutual adjustment for the other immune markers, sCD23 remained associated with all subtypes and CXCL13 with FL and DLBCL. The associations of sCD23 with CLL and DLBCL and CXCL13 with DLBCL persisted among cases sampled > 9 years before diagnosis. sCD23 showed a good predictive ability (area under the curve = 0.80) for CLL, in particular among older, male participants. sCD23 and CXCL13 showed a mediating effect between body mass index (positive) and DLBCL risk, while CXCL13 contributed to the association between physical activity (inverse) and DLBCL. Our data suggest a role of B-cell activation in BCL development and a mediating role of the immune system for lifestyle factors. © 2020, The Author(s).

Published
2020

10. Inflammatory potential of diet and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition

Author

Solans, M. Benavente, Y. Saez, M. Agudo, A. Jakszyn, P. Naudin, S. Hosnijeh, F.S. Gunter, M. Huybrechts, I. Ferrari, P. Besson, C. Mahamat-Saleh, Y. Boutron-Ruault, M.-C. Kühn, T. Kaaks, R. Boeing, H. Lasheras, C. Sánchez, M.-J. Amiano, P. Chirlaque, M.D. Ardanaz, E. Schmidt, J.A. Vineis, P. Riboli, E. Trichopoulou, A. Karakatsani, A. Valanou, E. Masala, G. Agnoli, C. Tumino, R. Sacerdote, C. Mattiello, A. Skeie, G. Weiderpass, E. Jerkeman, M. Dias, J.A. Späth, F. Nilsson, L.M. Dahm, C.C. Overvad, K. Petersen, K.E.N. Tjønneland, A. de Sanjose, S. Vermeulen, R. Nieters, A. Casabonne, D.

Subjects
hemic and lymphatic diseases
Abstract

Introduction: Chronic inflammation plays a critical role in lymphomagenesis and several dietary factors seem to be involved its regulation. The aim of the current study was to assess the association between the inflammatory potential of the diet and the risk of lymphoma and its subtypes in the European Investigation into Cancer and Nutrition (EPIC) study. Methods: The analysis included 476,160 subjects with an average follow-up of 13.9 years, during which 3,136 lymphomas (135 Hodgkin lymphoma (HL), 2606 non-Hodgkin lymphoma (NHL) and 395 NOS) were identified. The dietary inflammatory potential was assessed by means of an inflammatory score of the diet (ISD), calculated using 28 dietary components and their corresponding inflammatory weights. The association between the ISD and lymphoma risk was estimated by hazard ratios (HR) and 95% confidence intervals (CI) calculated by multivariable Cox regression models adjusted for potential confounders. Results: The ISD was not associated with overall lymphoma risk. Among lymphoma subtypes, a positive association between the ISD and mature B-cell NHL (HR for a 1-SD increase: 1.07 (95% CI 1.01; 1.14), p trend = 0.03) was observed. No statistically significant association was found among other subtypes. However, albeit with smaller number of cases, a suggestive association was observed for HL (HR for a 1-SD increase = 1.22 (95% CI 0.94; 1.57), p trend 0.13). Conclusions: Our findings suggested that a high ISD score, reflecting a pro-inflammatory diet, was modestly positively associated with the risk of B-cell lymphoma subtypes. Further large prospective studies on low-grade inflammation induced by diet are warranted to confirm these findings. © 2019, Springer-Verlag GmbH Germany, part of Springer Nature.

Published
2020

11. Healthy lifestyle and the risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition study

Author

Naudin, S. Solans Margalef, M. Saberi Hosnijeh, F. Nieters, A. Kyrø, C. Tjønneland, A. Dahm, C.C. Overvad, K. Mahamat-Saleh, Y. Besson, C. Boutron-Ruault, M.-C. Kühn, T. Canzian, F. Schulze, M.B. Peppa, E. Karakatsani, A. Trichopoulou, A. Sieri, S. Masala, G. Panico, S. Tumino, R. Ricceri, F. Chen, S.L.F. Barroso, L.L. Huerta, J.M. Sánchez, M.-J. Ardanaz, E. Menéndez, V. Amiano Exezarreta, P. Spaeth, F. Jerkeman, M. Jirstom, K. Schmidt, J.A. Aune, D. Weiderpass, E. Riboli, E. Vermeulen, R. Casabonne, D. Gunter, M. Brennan, P. Ferrari, P.

Subjects
immune system diseases, hemic and lymphatic diseases
Abstract

Limited evidence exists on the role of modifiable lifestyle factors on the risk of lymphoma. In this work, the associations between adherence to healthy lifestyles and risks of Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) were evaluated in a large-scale European prospective cohort. Within the European Prospective Investigation into Cancer and Nutrition (EPIC), 2,999 incident lymphoma cases (132 HL and 2,746 NHL) were diagnosed among 453,808 participants after 15 years (median) of follow-up. The healthy lifestyle index (HLI) score combined information on smoking, alcohol intake, diet, physical activity and BMI, with large values of HLI expressing adherence to healthy behavior. Cox proportional hazards models were used to estimate lymphoma hazard ratios (HR) and 95% confidence interval (CI). Sensitivity analyses were conducted by excluding, in turn, each lifestyle factor from the HLI score. The HLI was inversely associated with HL, with HR for a 1-standard deviation (SD) increment in the score equal to 0.78 (95% CI: 0.66, 0.94). Sensitivity analyses showed that the association was mainly driven by smoking and marginally by diet. NHL risk was not associated with the HLI, with HRs for a 1-SD increment equal to 0.99 (0.95, 1.03), with no evidence for heterogeneity in the association across NHL subtypes. In the EPIC study, adherence to healthy lifestyles was not associated with overall lymphoma or NHL risk, while an inverse association was observed for HL, although this was largely attributable to smoking. These findings suggest a limited role of lifestyle factors in the etiology of lymphoma subtypes. © 2020 UICC

Published
2020

12. Serum levels of hsa-miR-16-5p, hsa-miR-29a-3p, hsa-miR-150-5p, hsa-miR-155-5p and hsa-miR-223-3p and subsequent risk of chronic lymphocytic leukemia in the EPIC study

Author

Casabonne, D. Benavente, Y. Seifert, J. Costas, L. Armesto, M. Arestin, M. Besson, C. Hosnijeh, F.S. Duell, E.J. Weiderpass, E. Masala, G. Kaaks, R. Canzian, F. Chirlaque, M.-D. Perduca, V. Mancini, F.R. Pala, V. Trichopoulou, A. Karakatsani, A. La Vecchia, C. Sánchez, M.-J. Tumino, R. Gunter, M.J. Amiano, P. Panico, S. Sacerdote, C. Schmidt, J.A. Boeing, H. Schulze, M.B. Barricarte, A. Riboli, E. Olsen, A. Tjønneland, A. Vermeulen, R. Nieters, A. Lawrie, C.H. de Sanjosé, S.

Subjects
body regions, embryonic structures
Abstract

Chronic lymphocytic leukemia (CLL) is an incurable disease accounting for almost one-third of leukemias in the Western world. Aberrant expression of microRNAs (miRNAs) is a well-established characteristic of CLL, and the robust nature of miRNAs makes them eminently suitable liquid biopsy biomarkers. Using a nested case–control study within the European Prospective Investigation into Cancer and Nutrition (EPIC), the predictive values of five promising human miRNAs (hsa-miR-16-5p, hsa-miR-29a-3p, hsa-miR-150-5p, hsa-miR-155-5p and hsa-miR-223-3p), identified in a pilot study, were examined in serum of 224 CLL cases (diagnosed 3 months to 18 years after enrollment) and 224 matched controls using Taqman based assays. Conditional logistic regressions were applied to adjust for potential confounders. The median time from blood collection to CLL diagnosis was 10 years (p25–p75: 7–13 years). Overall, the upregulation of hsa-miR-150-5p, hsa-miR-155-5p and hsa-miR-29a-3p was associated with subsequent risk of CLL [OR1∆Ct-unit increase (95%CI) = 1.42 (1.18–1.72), 1.64 (1.31–2.04) and 1.75 (1.31–2.34) for hsa-miR-150-5p, hsa-miR-155-5p and hsa-miR-29a-3p, respectively] and the strongest associations were observed within 10 years of diagnosis. However, the predictive performance of these miRNAs was modest (area under the curve

Published
2020

13. Association between anthropometry and lifestyle factors and risk of B-cell lymphoma: An exposome-wide analysis

Author

Saberi Hosnijeh, F. (Fatemeh), Casabonne, D. (Delphine), Nieters, A. (Alexandra), Solans, M. (Marta), Naudin, S. (Sabine), Ferrari, P. (Pietro), Mckay, J.D. (James D.), Benavente, Y. (Yolanda), Weiderpass, E. (Elisabete), Freisling, H. (Heinz), Severi, G. (Gianluca), Boutron Ruault, M.-C. (Marie-Christine), Besson, C. (Caroline), Agnoli, C. (Claudia), Masala, G. (Giovanna), Sacerdote, C. (Carlotta), Tumino, R. (Rosario), Huerta, J.M. (José María), Amiano, P. (Pilar), Rodriguez-Barranco, M. (Miguel), Bonet, C. (Catalina), Barricarte, A. (Aurelio), Christakoudi, S. (Sofia), Knuppel, A. (Anika), Bueno-de-Mesquita, B. (Bas), Schulze, M.B. (Matthias), Kaaks, R. (Rudolf), Canzian, F. (Federico), Späth, F. (Florentin), Jerkeman, M. (Mats), Rylander, C. (Charlotta), Tjønneland, A. (Anne), Olsen, A. (Anja), Borch, K.B. (Kristin Benjaminsen), Vermeulen, R. (Roel), Saberi Hosnijeh, F. (Fatemeh), Casabonne, D. (Delphine), Nieters, A. (Alexandra), Solans, M. (Marta), Naudin, S. (Sabine), Ferrari, P. (Pietro), Mckay, J.D. (James D.), Benavente, Y. (Yolanda), Weiderpass, E. (Elisabete), Freisling, H. (Heinz), Severi, G. (Gianluca), Boutron Ruault, M.-C. (Marie-Christine), Besson, C. (Caroline), Agnoli, C. (Claudia), Masala, G. (Giovanna), Sacerdote, C. (Carlotta), Tumino, R. (Rosario), Huerta, J.M. (José María), Amiano, P. (Pilar), Rodriguez-Barranco, M. (Miguel), Bonet, C. (Catalina), Barricarte, A. (Aurelio), Christakoudi, S. (Sofia), Knuppel, A. (Anika), Bueno-de-Mesquita, B. (Bas), Schulze, M.B. (Matthias), Kaaks, R. (Rudolf), Canzian, F. (Federico), Späth, F. (Florentin), Jerkeman, M. (Mats), Rylander, C. (Charlotta), Tjønneland, A. (Anne), Olsen, A. (Anja), Borch, K.B. (Kristin Benjaminsen), and Vermeulen, R. (Roel)

Abstract

To better understand the role of individual and lifestyle factors in human disease, an exposome-wide association study was performed to investigate within a single-study anthropometry measures and lifestyle factors previously associated with B-cell lymphoma (BCL). Within the European Prospective Investigation into Cancer and nutrition study, 2402 incident BCL cases were diagnosed from 475 426 participants that were followed-up on average 14 years. Standard and penalized Cox regression models as well as principal component analysis (PCA) were used to evaluate 84 exposures in relation to BCL risk. Standard and penalized Cox regression models showed a positive association between anthropometric measures and BCL and multiple myeloma/plasma cell neoplasm (MM). The penalized Cox models additionally showed the association between several exposures from categories of physical activity, smoking status, medical history, socioeconomic position, diet and BCL and/or the subtypes. PCAs confirmed the individual a

Published
2020
Full Text
View/download PDF

14. Mediating effect of soluble B-cell activation immune markers on the association between anthropometric and lifestyle factors and lymphoma development

Author

Saberi Hosnijeh, F. (Fatemeh), Kolijn, P.M. (Pieter M.), Casabonne, D. (Delphine), Nieters, A. (Alexandra), Solans, M. (Marta), Naudin, S. (Sabine), Ferrari, P. (Pietro), Mckay, J.D. (James D.), Weiderpass, E. (Elisabete), Perduca, V. (Vittorio), Besson, C. (Caroline), Mancini, F.R. (Francesca Romana), Masala, G. (Giovanna), Krogh, V. (Vittorio), Ricceri, F. (Fulvio), Huerta, J.M. (José M.), Petrova, D. (Dafina), Sala, N. (Núria), Trichopoulou, A. (Antonia), Karakatsani, A. (Anna), La Vecchia, C. (Carlo), Kaaks, R. (Rudolf), Canzian, F. (Federico), Aune, D. (Dagfinn), Boeing, H. (Heiner), Schulze, M.B. (Matthias), Perez-Cornago, A. (Aurora), Langerak, A.W. (Anton), Velden, V.H.J. (Vincent) van der, Vermeulen, R. (Roel), Saberi Hosnijeh, F. (Fatemeh), Kolijn, P.M. (Pieter M.), Casabonne, D. (Delphine), Nieters, A. (Alexandra), Solans, M. (Marta), Naudin, S. (Sabine), Ferrari, P. (Pietro), Mckay, J.D. (James D.), Weiderpass, E. (Elisabete), Perduca, V. (Vittorio), Besson, C. (Caroline), Mancini, F.R. (Francesca Romana), Masala, G. (Giovanna), Krogh, V. (Vittorio), Ricceri, F. (Fulvio), Huerta, J.M. (José M.), Petrova, D. (Dafina), Sala, N. (Núria), Trichopoulou, A. (Antonia), Karakatsani, A. (Anna), La Vecchia, C. (Carlo), Kaaks, R. (Rudolf), Canzian, F. (Federico), Aune, D. (Dagfinn), Boeing, H. (Heiner), Schulze, M.B. (Matthias), Perez-Cornago, A. (Aurora), Langerak, A.W. (Anton), Velden, V.H.J. (Vincent) van der, and Vermeulen, R. (Roel)

Abstract

Sustained B-cell activation is an important mechanism contributing to B-cell lymphoma (BCL). We aimed to validate four previously reported B-cell activation markers predictive of BCL risk (sCD23, sCD27, sCD30, and CXCL13) and to examine their possible mediating effects on the association between anthropometric and lifestyle factors and major BCL subtypes. Pre-diagnostic serum levels were measured for 517 BCL cases and 525 controls in a nested case–control study. The odds ratios of BCL were 6.2 in the highest versus lowest quartile for sCD23, 2.6 for sCD30, 4.2 for sCD27, and 2.6 for CXCL13. Higher levels of all markers were associated with increased risk of chronic lymphocytic leukemia (CLL), follicular lymphoma (FL), and diffuse large B-cell lymphoma (DLBCL). Following mutual adjustment for the other immune markers, sCD23 remained associated with all subtypes and CXCL13 with FL and DLBCL. The associations of sCD23 with CLL and DLBCL and CXCL13 with DLBCL persisted among cases sampled > 9 years before diagnosis. sCD23 showed a good predictive ability (area under the curve = 0.80) for CLL, in particular among older, male participants. sCD23 and CXCL13 showed a mediating effect between body mass index (positive) and DLBCL risk, while CXCL13 contributed to the association between physical activity (inverse) and DLBCL. Our data suggest a role of B-cell activation in BCL development and a mediating role of the immune system for lifestyle factors.

Published
2020
Full Text
View/download PDF

15. Mediating effect of soluble B-cell activation immune markers on the association between anthropometric and lifestyle factors and lymphoma development

Author

Saberi Hosnijeh, Fatemeh, Kolijn, Martijn, Casabonne, D, Nieters, A, Solans, M, Naudin, S, Ferrari, P, Mckay, JD, Weiderpass, E, Perduca, V, Besson, C, Mancini, FR, Masala, G, Krogh, V, Ricceri, F, Huerta, JM, Petrova, D, Sala, N, Trichopoulou, A, Karakatsani, A, La Vecchia, C, Kaaks, R, Canzian, F, Aune, D, Boeing, H, Schulze, MB, Perez-Cornago, A, Langerak, Ton, van der Velden, Vincent, Vermeulen, R, Saberi Hosnijeh, Fatemeh, Kolijn, Martijn, Casabonne, D, Nieters, A, Solans, M, Naudin, S, Ferrari, P, Mckay, JD, Weiderpass, E, Perduca, V, Besson, C, Mancini, FR, Masala, G, Krogh, V, Ricceri, F, Huerta, JM, Petrova, D, Sala, N, Trichopoulou, A, Karakatsani, A, La Vecchia, C, Kaaks, R, Canzian, F, Aune, D, Boeing, H, Schulze, MB, Perez-Cornago, A, Langerak, Ton, van der Velden, Vincent, and Vermeulen, R

Published
2020

19. Reproductive Factors, Exogenous Hormone Use, and Risk of B-Cell Non-Hodgkin Lymphoma in a Cohort of Women from the European Prospective Investigation into Cancer and Nutrition

Author

Costas, L. Lujan-Barroso, L. Benavente, Y. Allen, N.E. Amiano, P. Ardanaz, E. Besson, C. Boeing, H. Bueno-De-Mesquita, B. Cervenka, I. Fortner, R.T. Fournier, A. Gunter, M. Harlid, S. Huerta, J.M. Jerkeman, M. Jirström, K. Kaaks, R. Karakatsani, A. Khaw, K.-T. Kotanidou, A. Lund, E. Masala, G. Mattiello, A. Melin, B. Menéndez, V. Murphy, N. Nieters, A. Overvad, K. Riboli, E. Sacerdote, C. Sánchez, M.-J. Schmidt, J.A. Sieri, S. Tjønneland, A. Trichopoulou, A. Tumino, R. Vermeulen, R. Weiderpass, E. De Sanjosé, S. Agudo, A. Casabonne, D.

Abstract

The role of hormonal factors in the etiology of lymphoid neoplasms remains unclear. Previous studies have yielded conflicting results, have lacked sufficient statistical power to assess many lymphoma subtypes, or have lacked detailed information on relevant exposures. Within the European Prospective Investigation Into Cancer and Nutrition cohort, we analyzed comprehensive data on reproductive factors and exogenous hormone use collected at baseline (1992-2000) among 343,458 women, including data on 1,427 incident cases of B-cell non-Hodgkin lymphoma (NHL) and its major subtypes identified after a mean follow-up period of 14 years (through 2015). We estimated hazard ratios and 95% confidence intervals using multivariable proportional hazards modeling. Overall, we observed no statistically significant associations between parity, age at first birth, breastfeeding, oral contraceptive use, or ever use of postmenopausal hormone therapy and risk of B-cell NHL or its subtypes. Women who had undergone surgical menopause had a 51% higher risk of B-cell NHL (based on 67 cases) than women with natural menopause (hazard ratio = 1.51, 95% confidence interval: 1.17, 1.94). Given that this result may have been due to chance, our results provide little support for the hypothesis that sex hormones play a role in lymphomagenesis. © The Author(s) 2018.

Published
2019

20. Adherence to the mediterranean diet and lymphoma risk in the european prospective investigation into cancer and nutrition

Author

Solans, M. Benavente, Y. Saez, M. Agudo, A. Naudin, S. Hosnijeh, F.S. Noh, H. Freisling, H. Ferrari, P. Besson, C. Mahamat-Saleh, Y. Boutron-Ruault, M.-C. Kühn, T. Kaaks, R. Boeing, H. Lasheras, C. Rodríguez-Barranco, M. Amiano, P. Huerta, J.M. Barricarte, A. Schmidt, J.A. Vineis, P. Riboli, E. Trichopoulou, A. Bamia, C. Peppa, E. Masala, G. Agnoli, C. Tumino, R. Sacerdote, C. Panico, S. Skeie, G. Weiderpass, E. Jerkeman, M. Ericson, U. Späth, F. Nilsson, L.M. Dahm, C.C. Overvad, K. Bolvig, A.K. Tjønneland, A. de Sanjose, S. Buckland, G. Vermeulen, R. Nieters, A. Casabonne, D.

Abstract

There is a growing evidence of the protective role of the Mediterranean diet (MD) on cancer. However, no prospective study has yet investigated its influence on lymphoma. We evaluated the association between adherence to the MD and risk of lymphoma and its subtypes in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The analysis included 476,160 participants, recruited from 10 European countries between 1991 and 2001. Adherence to the MD was estimated through the adapted relative MD (arMED) score excluding alcohol. Cox proportional hazards regression models were used while adjusting for potential confounders. During an average follow-up of 13.9 years, 3,136 lymphomas (135 Hodgkin lymphoma [HL], 2,606 non-HL and 395 lymphoma not otherwise specified) were identified. Overall, a 1-unit increase in the arMED score was associated with a 2% lower risk of lymphoma (95% CI: 0.97; 1.00, p-trend = 0.03) while a statistically nonsignificant inverse association between a high versus low arMED score and risk of lymphoma was observed (hazard ratio [HR]: 0.91 [95% CI 0.80; 1.03], p-trend = 0.12). Analyses by lymphoma subtype did not reveal any statistically significant associations. Albeit with small numbers of cases (N = 135), a suggestive inverse association was found for HL (HR 1-unit increase = 0.93 [95% CI: 0.86; 1.01], p-trend = 0.07). However, the study may have lacked statistical power to detect small effect sizes for lymphoma subtype. Our findings suggest that an increasing arMED score was inversely related to the risk of overall lymphoma in EPIC but not by subtypes. Further large prospective studies are warranted to confirm these findings. © 2018 UICC

Published
2019

24. Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes

Author

Din, L., Sheikh, M., Kosaraju, N., Smedby, K.E., Bernatsky, S., Berndt, S.I., Skibola, C.F., Nieters, A., McKay, J.D., Cocco, P., Maynadié, M., Foretová, L., Staines, A., Mack, T.M., de Sanjosé, S., Vyse, T.J., Padyukov, L., Monnereau, A., Arslan, A.A., Moore, A., Brooks-Wilson, A.R., Glimelius, B., Birmann, B.M., Link, B.K., Stewart, C., Vajdic, C.M., Haioun, C., Magnani, C., Conti, D.V., Cox, D.G., Casabonne, D., Albanes, D., Kane, E., Roman, E., Muzi, G., Salles, G., Giles, G.G., Adami, H.-O., Ghesquières, H., De Vivo, I., Clavel, J., Cerhan, J.R., Spinelli, J.J., Vijai, J., Curtin, K., Costenbader, K.H., Onel, K., Offit, K., Teras, L.R., Morton, L., Conde, L., Miligi, L., Melbye, M., Ennas, M.G., Liebow, M., Purdue, M.P., Glenn, M., Southey, M.C., Din, M., Rothman, N., Camp, N.J., Wong Doo, N., Becker, N., Pradhan, N., Bracci, P.M., Boffetta, P., Vineis, P., Brennan, P., Kraft, P., Lan, Q., Severson, R.K., Vermeulen, R.C.H., Milne, R.L., Kaaks, R., Travis, R.C., Weinstein, S.J., Chanock, S.J., Ansell, S.M., Slager, S.L., Zheng, T., Benavente, Y., Taub, Z., Madireddy, L., Gourraud, P.-A., Oksenberg, J.R., Cozen, W., Hjalgrim, H., Khankhanian, P., Din, L., Sheikh, M., Kosaraju, N., Smedby, K.E., Bernatsky, S., Berndt, S.I., Skibola, C.F., Nieters, A., McKay, J.D., Cocco, P., Maynadié, M., Foretová, L., Staines, A., Mack, T.M., de Sanjosé, S., Vyse, T.J., Padyukov, L., Monnereau, A., Arslan, A.A., Moore, A., Brooks-Wilson, A.R., Glimelius, B., Birmann, B.M., Link, B.K., Stewart, C., Vajdic, C.M., Haioun, C., Magnani, C., Conti, D.V., Cox, D.G., Casabonne, D., Albanes, D., Kane, E., Roman, E., Muzi, G., Salles, G., Giles, G.G., Adami, H.-O., Ghesquières, H., De Vivo, I., Clavel, J., Cerhan, J.R., Spinelli, J.J., Vijai, J., Curtin, K., Costenbader, K.H., Onel, K., Offit, K., Teras, L.R., Morton, L., Conde, L., Miligi, L., Melbye, M., Ennas, M.G., Liebow, M., Purdue, M.P., Glenn, M., Southey, M.C., Din, M., Rothman, N., Camp, N.J., Wong Doo, N., Becker, N., Pradhan, N., Bracci, P.M., Boffetta, P., Vineis, P., Brennan, P., Kraft, P., Lan, Q., Severson, R.K., Vermeulen, R.C.H., Milne, R.L., Kaaks, R., Travis, R.C., Weinstein, S.J., Chanock, S.J., Ansell, S.M., Slager, S.L., Zheng, T., Benavente, Y., Taub, Z., Madireddy, L., Gourraud, P.-A., Oksenberg, J.R., Cozen, W., Hjalgrim, H., and Khankhanian, P.

Abstract

Epidemiologic studies show an increased risk of non-Hodgkin lymphoma (NHL) in patients with autoimmune disease (AD), due to a combination of shared environmental factors and/or genetic factors, or a causative cascade: chronic inflammation/antigen-stimulation in one disease leads to another. Here we assess shared genetic risk in genome-wide-association-studies (GWAS). Secondary analysis of GWAS of NHL subtypes (chronic lymphocytic leukemia, diffuse large B-cell lymphoma, follicular lymphoma, and marginal zone lymphoma) and ADs (rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis). Shared genetic risk was assessed by (a) description of regional genetic of overlap, (b) polygenic risk score (PRS), (c)"diseasome", (d)meta-analysis. Descriptive analysis revealed few shared genetic factors between each AD and each NHL subtype. The PRS of ADs were not increased in NHL patients (nor vice versa). In the diseasome, NHLs shared more genetic etiology with ADs than solid cancers (p = .0041). A meta-analysis (combing AD with NHL) implicated genes of apoptosis and telomere length. This GWAS-based analysis four NHL subtypes and three ADs revealed few weakly-associated shared loci, explaining little total risk. This suggests common genetic variation, as assessed by GWAS in these sample sizes, may not be the primary explanation for the link between these ADs and NHLs.

Published
2019

25. Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes

Author

Din, L, Sheikh, M, Kosaraju, N, Smedby, KE, Bernatsky, S, Berndt, S, Skibola, CF, Nieters, A, Wang, S, McKay, JD, Cocco, P, Maynadie, M, Foretova, L, Staines, A, Mack, TM, de Sanjose, S, Vyse, TJ, Padyukov, L, Monnereau, A, Arslan, AA, Moore, A, Brooks-Wilson, AR, Novak, AJ, Glimelius, B, Birmann, BM, Link, BK, Stewart, C, Vajdic, CM, Haioun, C, Magnani, C, Conti, D, Cox, DG, Casabonne, D, Albanes, D, Kane, E, Roman, E, Muzi, G, Salles, G, Giles, GG, Adami, H-O, Ghesquieres, H, De Vivo, I, Clavel, J, Cerhan, JR, Spinelli, JJ, Hofmann, J, Vijai, J, Curtin, K, Costenbader, KH, Onel, K, Offit, K, Teras, LR, Morton, L, Conde, L, Miligi, L, Melbye, M, Ennas, MG, Liebow, M, Purdue, MP, Glenn, M, Southey, MC, Din, M, Rothman, N, Camp, NJ, Doo, NW, Becker, N, Pradhan, N, Bracci, PM, Boffetta, P, Vineis, P, Brennan, P, Kraft, P, Lan, Q, Severson, RK, Vermeulen, RCH, Milne, RL, Kaaks, R, Travis, RC, Weinstein, SJ, Chanock, SJ, Ansell, SM, Slager, SL, Zheng, T, Zhang, Y, Benavente, Y, Taub, Z, Madireddy, L, Gourraud, P-A, Oksenberg, JR, Cozen, W, Hjalgrim, H, Khankhanian, P, Din, L, Sheikh, M, Kosaraju, N, Smedby, KE, Bernatsky, S, Berndt, S, Skibola, CF, Nieters, A, Wang, S, McKay, JD, Cocco, P, Maynadie, M, Foretova, L, Staines, A, Mack, TM, de Sanjose, S, Vyse, TJ, Padyukov, L, Monnereau, A, Arslan, AA, Moore, A, Brooks-Wilson, AR, Novak, AJ, Glimelius, B, Birmann, BM, Link, BK, Stewart, C, Vajdic, CM, Haioun, C, Magnani, C, Conti, D, Cox, DG, Casabonne, D, Albanes, D, Kane, E, Roman, E, Muzi, G, Salles, G, Giles, GG, Adami, H-O, Ghesquieres, H, De Vivo, I, Clavel, J, Cerhan, JR, Spinelli, JJ, Hofmann, J, Vijai, J, Curtin, K, Costenbader, KH, Onel, K, Offit, K, Teras, LR, Morton, L, Conde, L, Miligi, L, Melbye, M, Ennas, MG, Liebow, M, Purdue, MP, Glenn, M, Southey, MC, Din, M, Rothman, N, Camp, NJ, Doo, NW, Becker, N, Pradhan, N, Bracci, PM, Boffetta, P, Vineis, P, Brennan, P, Kraft, P, Lan, Q, Severson, RK, Vermeulen, RCH, Milne, RL, Kaaks, R, Travis, RC, Weinstein, SJ, Chanock, SJ, Ansell, SM, Slager, SL, Zheng, T, Zhang, Y, Benavente, Y, Taub, Z, Madireddy, L, Gourraud, P-A, Oksenberg, JR, Cozen, W, Hjalgrim, H, and Khankhanian, P

Abstract

Epidemiologic studies show an increased risk of non-Hodgkin lymphoma (NHL) in patients with autoimmune disease (AD), due to a combination of shared environmental factors and/or genetic factors, or a causative cascade: chronic inflammation/antigen-stimulation in one disease leads to another. Here we assess shared genetic risk in genome-wide-association-studies (GWAS). Secondary analysis of GWAS of NHL subtypes (chronic lymphocytic leukemia, diffuse large B-cell lymphoma, follicular lymphoma, and marginal zone lymphoma) and ADs (rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis). Shared genetic risk was assessed by (a) description of regional genetic of overlap, (b) polygenic risk score (PRS), (c)"diseasome", (d)meta-analysis. Descriptive analysis revealed few shared genetic factors between each AD and each NHL subtype. The PRS of ADs were not increased in NHL patients (nor vice versa). In the diseasome, NHLs shared more genetic etiology with ADs than solid cancers (p = .0041). A meta-analysis (combing AD with NHL) implicated genes of apoptosis and telomere length. This GWAS-based analysis four NHL subtypes and three ADs revealed few weakly-associated shared loci, explaining little total risk. This suggests common genetic variation, as assessed by GWAS in these sample sizes, may not be the primary explanation for the link between these ADs and NHLs.

Published
2019

27. Assessment of the combined effect of epstein-barr virus and plasmodium falciparum infections on endemic burkitt lymphoma using a multiplex serological approach.

Author

Casabonne D., Mutalima N., Angov E., Dutta S., Gaur D., Chitnis C.E., Chauhan V., Michel A., de Sanjose S., Waterboer T., Kogevinas M., Newton R., Dobano C., Aguilar R., O'Callaghan-Gordo C., Vidal M., Campo J.J., Casabonne D., Mutalima N., Angov E., Dutta S., Gaur D., Chitnis C.E., Chauhan V., Michel A., de Sanjose S., Waterboer T., Kogevinas M., Newton R., Dobano C., Aguilar R., O'Callaghan-Gordo C., Vidal M., and Campo J.J.

Abstract

Epstein-Barr virus (EBV) is a necessary cause of endemic Burkitt lymphoma (eBL), while the role of Plasmodium falciparum in eBL remains uncertain. This study aimed to generate new hypotheses on the interplay between both infections in the development of eBL by investigating the IgG and IgM profiles against several EBV and P. falciparum antigens. Serum samples collected in a childhood study in Malawi (2005-2006) from 442 HIV-seronegative children (271 eBL cases and 171 controls) between 1.4 and 15 years old were tested by quantitative suspension array technology against a newly developed multiplex panel combining 4 EBV antigens [Z Epstein-Barr replication activator protein (ZEBRA), early antigen-diffuse component (EA-D), EBV nuclear antigen 1, and viral capsid antigen p18 subunit (VCA-p18)] and 15 P. falciparum antigens selected for their immunogenicity, role in malaria pathogenesis, and presence in different parasite stages. Principal component analyses, multivariate logistic models, and elastic-net regressions were used. As expected, elevated levels of EBV IgG (especially against the lytic antigens ZEBRA, EA-D, and VCA-p18) were strongly associated with eBL [high vs low tertile odds ratio (OR) = 8.67, 95% confidence interval (CI) = 4.81-15.64]. Higher IgG responses to the merozoite surface protein 3 were observed in children with eBL compared with controls (OR = 1.29, 95% CI = 1.02-1.64), showing an additive interaction with EBV IgGs (OR = 10.6, 95% CI = 5.1-22.2, P = 0.05). Using elastic-net regression models, eBL serological profile was further characterized by lower IgM levels against P. falciparum preerythrocytic-stage antigen CelTOS and EBV lytic antigen VCA-p18 compared with controls. In a secondary analysis, abdominal Burkitt lymphoma had lower IgM to EBV and higher IgG to EA-D levels than cases with head involvement. Overall, this exploratory study confirmed the strong role of EBV in eBL and identified differential IgG and IgM patterns to erythrocytic vs pr

Published
2017

28. Antibodies against malaria and Epstein-Barr virus in childhood Burkitt lymphoma: a case-control study in Uganda

Author

Carpenter, LM, Newton, R, Casabonne, D, Ziegler, J, Mbulaiteye, S, Mbidde, E, Wabinga, H, Jaffe, H, Beral, V, and (UICC), Union for International Cancer Control

Subjects
hemic and lymphatic diseases, parasitic diseases, Public Health, Malaria
Abstract

Burkitt lymphoma, a childhood tumor common in parts of sub-Saharan Africa, has been directly associated with Epstein-Barr virus (EBV) and indirectly with prevalence of malaria. We studied antibodies to both EBV and malaria in children diagnosed with this cancer in Uganda. We performed a case-control study of HIV-seronegative children (

Published
2016

34. Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia

Author

Berndt, SI, Camp, NJ, Skibola, CF, Vijai, J, Wang, Z, Gu, J, Nieters, A, Kelly, RS, Smedby, KE, Monnereau, A, Cozen, W, Cox, A, Wang, SS, Lan, Q, Teras, LR, Machado, M, Yeager, M, Brooks-Wilson, AR, Hartge, P, Purdue, MP, Birmann, BM, Vajdic, CM, Cocco, P, Zhang, Y, Giles, GG, Zeleniuch-Jacquotte, A, Lawrence, C, Montalvan, R, Burdett, L, Hutchinson, A, Ye, Y, Call, TG, Shanafelt, TD, Novak, AJ, Kay, NE, Liebow, M, Cunningham, JM, Allmer, C, Hjalgrim, H, Adami, H-O, Melbye, M, Glimelius, B, Chang, ET, Glenn, M, Curtin, K, Cannon-Albright, LA, Diver, WR, Link, BK, Weiner, GJ, Conde, L, Bracci, PM, Riby, J, Arnett, DK, Zhi, D, Leach, JM, Holly, EA, Jackson, RD, Tinker, LF, Benavente, Y, Sala, N, Casabonne, D, Becker, N, Boffetta, P, Brennan, P, Foretova, L, Maynadie, M, McKay, J, Staines, A, Chaffee, KG, Achenbach, SJ, Vachon, CM, Goldin, LR, Strom, SS, Leis, JF, Weinberg, JB, Caporaso, NE, Norman, AD, De Roos, AJ, Morton, LM, Severson, RK, Riboli, E, Vineis, P, Kaaks, R, Masala, G, Weiderpass, E, Chirlaque, M-D, Vermeulen, RCH, Travis, RC, Southey, MC, Milne, RL, Albanese, D, Virtamo, J, Weinstein, S, Clavel, J, Zheng, T, Holford, TR, Villano, DJ, Maria, A, Spinelli, JJ, Gascoyne, RD, Connors, JM, Bertrand, KA, Giovannucci, E, Kraft, P, Kricker, A, Turner, J, Ennas, MG, Ferri, GM, Miligi, L, Liang, L, Ma, B, Huang, J, Crouch, S, Park, J-H, Chatterjee, N, North, KE, Snowden, JA, Wright, J, Fraumeni, JF, Offit, K, Wu, X, de Sanjose, S, Cerhan, JR, Chanock, SJ, Rothman, N, Slager, SL, Berndt, SI, Camp, NJ, Skibola, CF, Vijai, J, Wang, Z, Gu, J, Nieters, A, Kelly, RS, Smedby, KE, Monnereau, A, Cozen, W, Cox, A, Wang, SS, Lan, Q, Teras, LR, Machado, M, Yeager, M, Brooks-Wilson, AR, Hartge, P, Purdue, MP, Birmann, BM, Vajdic, CM, Cocco, P, Zhang, Y, Giles, GG, Zeleniuch-Jacquotte, A, Lawrence, C, Montalvan, R, Burdett, L, Hutchinson, A, Ye, Y, Call, TG, Shanafelt, TD, Novak, AJ, Kay, NE, Liebow, M, Cunningham, JM, Allmer, C, Hjalgrim, H, Adami, H-O, Melbye, M, Glimelius, B, Chang, ET, Glenn, M, Curtin, K, Cannon-Albright, LA, Diver, WR, Link, BK, Weiner, GJ, Conde, L, Bracci, PM, Riby, J, Arnett, DK, Zhi, D, Leach, JM, Holly, EA, Jackson, RD, Tinker, LF, Benavente, Y, Sala, N, Casabonne, D, Becker, N, Boffetta, P, Brennan, P, Foretova, L, Maynadie, M, McKay, J, Staines, A, Chaffee, KG, Achenbach, SJ, Vachon, CM, Goldin, LR, Strom, SS, Leis, JF, Weinberg, JB, Caporaso, NE, Norman, AD, De Roos, AJ, Morton, LM, Severson, RK, Riboli, E, Vineis, P, Kaaks, R, Masala, G, Weiderpass, E, Chirlaque, M-D, Vermeulen, RCH, Travis, RC, Southey, MC, Milne, RL, Albanese, D, Virtamo, J, Weinstein, S, Clavel, J, Zheng, T, Holford, TR, Villano, DJ, Maria, A, Spinelli, JJ, Gascoyne, RD, Connors, JM, Bertrand, KA, Giovannucci, E, Kraft, P, Kricker, A, Turner, J, Ennas, MG, Ferri, GM, Miligi, L, Liang, L, Ma, B, Huang, J, Crouch, S, Park, J-H, Chatterjee, N, North, KE, Snowden, JA, Wright, J, Fraumeni, JF, Offit, K, Wu, X, de Sanjose, S, Cerhan, JR, Chanock, SJ, Rothman, N, and Slager, SL

Abstract

Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P=2.55 × 10(-11)), 6p25.2 (rs73718779, SERPINB6, P=1.97 × 10(-8)) and 3q28 (rs9815073, LPP, P=3.62 × 10(-8)), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P=1.00 × 10(-11)) in the combined analysis. We find suggestive evidence (P<5 × 10(-7)) for two additional new loci at 4q24 (rs10028805, BANK1, P=7.19 × 10(-8)) and 3p22.2 (rs1274963, CSRNP1, P=2.12 × 10(-7)). Pathway analyses of new and known CLL loci consistently show a strong role for apoptosis, providing further evidence for the importance of this biological pathway in CLL susceptibility.

Published
2016

35. Occupational exposure to endocrine disruptors and lymphoma risk in a multi-centric European study

Author

Costas, L, primary, Infante-Rivard, C, additional, Zock, J-P, additional, Van Tongeren, M, additional, Boffetta, P, additional, Cusson, A, additional, Robles, C, additional, Casabonne, D, additional, Benavente, Y, additional, Becker, N, additional, Brennan, P, additional, Foretova, L, additional, Maynadié, M, additional, Staines, A, additional, Nieters, A, additional, Cocco, P, additional, and de Sanjosé, S, additional

Published
2015
Full Text
View/download PDF

36. Lifestyle factors and primary glioma and meningioma tumours in the Million Women Study cohort

Author

Benson VS, Pirie K, Green J, Casabonne D, Beral V, and for the Million Women Study Collaborators (incl. Canfell K)

Subjects
Risk, Incidence, Research, Smoking, Great Britain, Glioma, Middle Aged, Etiology - Resources and Infrastructure, Body Height, Body Mass Index, Central Nervous System Neoplasms, Cohort Studies, Risk Factors, Humans, cancer, Women, epidemiology, Female, Prospective Studies, Meningioma, Life Style, Aged
Abstract

Previous studies have reported inconsistent results on the effect of anthropometric and lifestyle factors on the risk of developing glioma or meningioma tumours. A prospective cohort of 1.3 million middle-aged women was used to examine these relationships. During 7.7 million women-years of follow-up, a total of 1563 women were diagnosed with a primary incident central nervous system tumour: 646 tumours were classified as glioma and 390 as meningioma. Our results show that height is related to the incidence of all central nervous system tumours with a risk of about 20% per 10 cm increase in height (relative risk=1.19, 95% CI=1.10-1.30 per 10 cm increase in height, P

Published
2009

37. Helicobacter pylori and cancer among adults in Uganda

Author

Newton, R., Ziegler, J.L., Carpenter, L., Gold, B.D., Owens, M., Beral, V., Mbidde, E., Parkin, D.M., Wabir, H., Mbulaiteye, S., Jaffe, H., Uganda, Kaposi's Sarcoma Study Group, and Casabonne, D.

Abstract

Data from Africa on infection with Helicobacter pylori (H. pylori) are sparse. Therefore, as part of an epidemiological study of cancer in Uganda, we investigated the prevalence and determinants of antibodies against H. pylori among 854 people with different cancer types and benign tumours. Patients were recruited from hospitals in Kampala, Uganda, interviewed about various demographic and lifestyle factors and tested for antibodies against H. pylori. In all patients combined, excluding those with stomach cancer (which has been associated with H. pylori infection), the prevalence of antibodies was 87% (723/833) overall, but declined with increasing age (p = 0.02) and was lower among people who were HIV seropositive compared to seronegative (p

Published
2006

40. Medical History, Lifestyle, Family History, and Occupational Risk Factors for Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: The InterLymph Non-Hodgkin Lymphoma Subtypes Project

Author

Slager, S. L., primary, Benavente, Y., additional, Blair, A., additional, Vermeulen, R., additional, Cerhan, J. R., additional, Costantini, A. S., additional, Monnereau, A., additional, Nieters, A., additional, Clavel, J., additional, Call, T. G., additional, Maynadie, M., additional, Lan, Q., additional, Clarke, C. A., additional, Lightfoot, T., additional, Norman, A. D., additional, Sampson, J. N., additional, Casabonne, D., additional, Cocco, P., additional, and de Sanjose, S., additional

Published
2014
Full Text
View/download PDF

42. 3.10 Risk Factors Associated with Chronic Lymphocytic Leukaemia in a Spanish Case−Control Study (MCC−Spain)

Author

Benavente, Y., primary, Casabonne, D., additional, Robles, C., additional, Costas, L., additional, Aymerich, M., additional, Peiró-Pérez, R., additional, Gomez-Acebo, I., additional, López Guillermo, A., additional, Tardón, A., additional, Salar, A., additional, Pollán, M., additional, Kogevinas, M., additional, Lopez-Otín, C., additional, Campo, E., additional, and denome Pe Sanjosé, S., additional

Published
2011
Full Text
View/download PDF

43. Antibodies against lytic and latent Kaposi's sarcoma-associated herpes virus antigens and lymphoma in the European EpiLymph case–control study

Author

Benavente, Y, primary, Mbisa, G, additional, Labo, N, additional, Casabonne, D, additional, Becker, N, additional, Maynadie, M, additional, Foretova, L, additional, Cocco, P L, additional, Nieters, A, additional, Staines, A, additional, Bofetta, P, additional, Brennan, P, additional, Whitby, D, additional, and de Sanjosé, S, additional

Published
2011
Full Text
View/download PDF

45. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph

Author

Casabonne, D., primary, Reina, O., additional, Benavente, Y., additional, Becker, N., additional, Maynadie, M., additional, Foretova, L., additional, Cocco, P., additional, Gonzalez-Neira, A., additional, Nieters, A., additional, Boffetta, P., additional, Middeldorp, J. M., additional, and de Sanjose, S., additional

Published
2010
Full Text
View/download PDF

50. Reproductive factors and lymphoid neoplasms in Europe: findings from the EpiLymph case-control study.

Author

Costas L, Casabonne D, Benavente Y, Becker N, Boffetta P, Brennan P, Cocco P, Foretova L, Maynadié M, Staines A, Kane E, Nieters A, and de Sanjosé S

Abstract

Background: The study of lymphomagenesis has rarely focused on hormonal factors. Higher incidence rates are observed for many lymphoma subtypes in men compared with women suggesting an underlying association. Our goal was to investigate the association between reproductive factors and lymphomas. Methods: The Epilymph study is a multicenter case-control study carried out in six European countries from 1998 to 2004. Female cases of mature T-cell neoplasms ( n = 52), Hodgkin lymphoma ( n = 147), and mature B-cell neoplasms ( n = 795), including its common subtypes, and their respective controls ( n = 1,141) frequency matched by age, gender, and center were considered. Results: An odds reduction of 29% (95% CI −46 to −6%) was observed for mature T-cell neoplasms for each child increase among parous women and of 13% (95% CI −19 to −7%) for mature B-cell neoplasms; while no association was observed for Hodgkin lymphoma. By B-cell neoplasm subtypes, these associations were found for chronic lymphocytic leukemia/small lymphocytic lymphoma (−21%, 95% CI −31 to −9%) and diffuse large B-cell lymphoma (DLBCL; −14%; 95% CI −23 to −3%). Overall, no associations were observed with age at first and last pregnancy, and ever use of hormonal contraceptives and lymphoma. Higher odds ratios for a short-term use of hormonal contraceptives (<5 years), but not for a long-term use, were observed for mature B-cell neoplasms, DLBCL, and follicular lymphoma compared with never use. Conclusion: These data support the hypothesis that increased parity confers a protective effect against lymphoma. Less clearly, our results also indicate that hormonal contraceptives could play a role. [ABSTRACT FROM AUTHOR]

Published
2012
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results