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Digital images are ubiquitous in our modern lives, with uses ranging from social media to news, and even scientific papers. For this reason, it is crucial evaluate how accurate people are when performing the task of identify doctored images. In this paper, we performed an extensive user study evaluating subjects capacity to detect fake images. After observing an image, users have been asked if it had been altered or not. If the user answered the image has been altered, he had to provide evidence in the form of a click on the image. We collected 17,208 individual answers from 383 users, using 177 images selected from public forensic databases. Different from other previously studies, our method propose different ways to avoid lucky guess when evaluating users answers. Our results indicate that people show inaccurate skills at differentiating between altered and non-altered images, with an accuracy of 58%, and only identifying the modified images 46.5% of the time. We also track user features such as age, answering time, confidence, providing deep analysis of how such variables influence on the users' performance.

Dent's disease is an X-linked recessive disease characterized by proximal tubulopathy with low-molecular weight proteinuria, hypercalciuria, nephrolithiasis, nephrocalcinosis, and kidney failure. It is mainly caused by mutations in the CLCN5 or OCRL1 genes, and only ~ 250 families have been identified with these mutations. We present a 31-year-old male referred to a nephrology consultation due to elevated serum creatinine and a history of nephrolithiasis. Complementary evaluation revealed protein/creatinine ratio of 1.9 g/g and albumin/creatinine ratio of 0.5 g/g, hypercalciuria and medullary nephrocalcinosis. These findings raised the suspicion of Dent's disease, which was confirmed by genetic testing. A missense mutation in the CLCN5 gene (c.810C>G, p.(Ser270Arg)), not previously reported in populational databases, was identified. During the evaluation of the patient, it came to our attention that a first-degree male cousin was being followed in our kidney transplantation unit. Given the unknown etiology of his chronic kidney disease, genetic testing was performed, identifying the same mutation. This case highlights the importance of considering the diagnosis of Dent's disease in the setting of a male patient with chronic kidney disease of unknown etiology, low-molecular-weight proteinuria, hypercalciuria, and nephrocalcinosis. Despite progression to end-stage kidney failure in a significant portion of male patients, there are no reports of recurrence after kidney transplantation., (© Dustri-Verlag Dr. K. Feistle.)