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22 results on '"Carvalho, Cristiano Marcelo Espinola"'

2. Pathophysiology to Risk Factor and Therapeutics to Treatment Strategies on Epilepsy

Author

Boleti, Ana Paula de Araújo, primary, Cardoso, Pedro Henrique de Oliveira, additional, Frihling, Breno Emanuel Farias, additional, de Moraes, Luiz Filipe Ramalho Nunes, additional, Nunes, Ellynes Amancio Correia, additional, Mukoyama, Lincoln Takashi Hota, additional, Nunes, Ellydberto Amancio Correia, additional, Carvalho, Cristiano Marcelo Espinola, additional, Macedo, Maria Lígia Rodrigues, additional, and Migliolo, Ludovico, additional

Published
2024
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3. Purification, Characterization and Evaluation of the Antitumoral Activity of a Phospholipase A2 from the Snake Bothrops moojeni

Author

Frihling, Breno Emanuel Farias, primary, Boleti, Ana Paula de Araújo, additional, de Oliveira, Caio Fernando Ramalho, additional, Sanches, Simone Camargo, additional, Cardoso, Pedro Henrique de Oliveira, additional, Verbisck, Newton, additional, Macedo, Maria Lígia Rodrigues, additional, Rita, Paula Helena Santa, additional, Carvalho, Cristiano Marcelo Espinola, additional, and Migliolo, Ludovico, additional

Published
2022
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4. Do Bioactive Food Compound with Avena sativa L., Linum usitatissimum L. and Glycine max L. Supplementation with Moringa oleifera Lam. Have a Role against Nutritional Disorders? An Overview of the In Vitro and In Vivo Evidence

Author

Ferreira, Rosângela dos Santos, primary, Mendonça, Lígia Aurélio Bezerra Maranhão, additional, Santos, Cristiane dos, additional, Hiane, Priscila Aiko, additional, Matias, Rosemary, additional, Franco, Octávio Luiz, additional, de Oliveira, Ademir Kleber Morbeck, additional, do Nascimento, Valter Aragão, additional, Pott, Arnildo, additional, Carvalho, Cristiano Marcelo Espinola, additional, and Guimarães, Rita de Cássia Avellaneda, additional

Published
2021
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5. Relationship between intestinal microbiota, diet and biological systems: an integrated view.

Author

Ferreira, Rosângela dos Santos, Mendonça, Lígia Aurélio Bezerra Maranhão, Ribeiro, Camila Fontoura Acosta, Calças, Natali Camposano, Guimarães, Rita de Cássia Avellaneda, Nascimento, Valter Aragão do, Gielow, Karine de Cássia Freitas, Carvalho, Cristiano Marcelo Espinola, Castro, Alinne Pereira de, and Franco, Octávio Luiz

Subjects
GUT microbiome, BIOLOGICAL systems, PREBIOTICS, UNSATURATED fatty acids, DIET, BACTERIAL metabolism
Abstract

The health-disease process can be influenced by the intestinal microbiota. As this plays a fundamental role in protecting the organism, the importance of studying the composition and diversity of this community becomes increasingly evident. Changes in the composition of the intestinal bacterial community may result in dysbiosis, and this process may contribute to triggering various diseases in all biological systems. This imbalance of intestinal microbiota homeostasis may alter commensal bacteria and the host metabolism, as well as immune function. Dysbiosis also causes an increase in intestinal permeability due to exposure to molecular patterns associated with the pathogen and lipopolysaccharides, leading to a chronic inflammatory process that can result in diseases for all biological systems. In this context, dietary intervention through the use of probiotics, prebiotics and antioxidant foods can be considered a contribution to the modulation of intestinal microbiota. Probiotics have been used to provide up to 10 billion colony forming units, and probiotic foods, Kefir and fermented natural yogurt are also used. Prebiotics, in turn, are found in supplemental formulations of processed foods and in functional foods that are also sources of phenolic compounds, such as flavonoids, antioxidant and anti-inflammatory substances, polyunsaturated fatty acids, vitamins, and minerals. In this review, we will discuss the relationship between an imbalance in the intestinal microbiota with the development of diseases, besides indicating the need for future studies that can establish bacterial parameters for the gastrointestinal tract by modulating the intestinal microbiota, associated with the adoption of healthy habits during all life cycles. [ABSTRACT FROM AUTHOR]

Published
2022
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6. Relationship between intestinal microbiota, diet and biological systems: an integrated view

Author

Ferreira, Rosângela dos Santos, primary, Mendonça, Lígia Aurélio Bezerra Maranhão, additional, Ribeiro, Camila Fontoura Acosta, additional, Calças, Natali Camposano, additional, Guimarães, Rita de Cássia Avellaneda, additional, Nascimento, Valter Aragão do, additional, Gielow, Karine de Cássia Freitas, additional, Carvalho, Cristiano Marcelo Espinola, additional, Castro, Alinne Pereira de, additional, and Franco, Octávio Luiz, additional

Published
2020
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7. Potential role of zinc in the visceromegaly regression and recovery of hematological parameters during treatment of visceral leishmaniasis in children from an endemic area

Author

Carbone, Débora Cardozo Bonfim, primary, Zanoni, Lourdes Zélia Garcia, additional, Cônsolo, Fernanda Zanoni, additional, Sanches, Simone Camargo, additional, Reis, Vanessa Quadros dos, additional, Muller, Karla de Toledo Candido, additional, Carvalho, Cristiano Marcelo Espinola, additional, and Silva, Maria Cláudia, additional

Published
2018
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12. CULTIVO IN VITRO DE SALVIA HISPANICA L

Author

Arfux, Claudia Regina Baur, primary, Menegati, Celia de Fátima, additional, Silva, Renata Moreira da, additional, Rondon, Josimara Nolasco, additional, Gabriel, Valdinez, additional, Costa, Francilina Araujo, additional, Carvalho, Cristiano Marcelo Espinola, additional, Souza, Pricila Fatima de, additional, and Silva, Cristiane Bezerra da, additional

Published
2015
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13. BIORREMEDIAÇÃO E REMEDIAÇÃO COM FLUIDO ÁCIDO RESIDUAL

Author

Rondon, Josimara Nolasco, primary, Aguiar, Mariane Baia de, additional, Pimenta, Talita Thais Correia, additional, Otsubo, Helena de Cassia Brassaloti, additional, Thomazelli Junior, Ismael, additional, Rondon, Marcelo Nolasco, additional, Fabri, João Roberto, additional, Carvalho, Cristiano Marcelo Espinola, additional, and Morais, Digelson Pazeto, additional

Published
2014
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14. EFEITO LARVICIDA DE RICINUS COMMUNIS L

Author

Neves, Renato Teles, primary, Rondon, Josimara Nolasco, additional, Silva, Lenice Inácio Mota da, additional, Peruca, Ricardo Dias, additional, Ítavo, Luiz Carlos Vinhas, additional, Carvalho, Cristiano Marcelo Espinola, additional, Souza, Antonio Pancracio de, additional, and Fabri, Joao Roberto, additional

Published
2014
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16. Inducible Nitric Oxide Synthase in Heart Tissue and Nitric Oxide in Serum of Trypanosoma cruzi-Infected Rhesus Monkeys: Association with Heart Injury

Author

Carvalho, Cristiano Marcelo Espinola, primary, Silverio, Jaline Coutinho, additional, da Silva, Andrea Alice, additional, Pereira, Isabela Resende, additional, Coelho, Janice Mery Chicarino, additional, Britto, Constança Carvalho, additional, Moreira, Otacílio Cruz, additional, Marchevsky, Renato Sergio, additional, Xavier, Sergio Salles, additional, Gazzinelli, Ricardo Tostes, additional, da Glória Bonecini-Almeida, Maria, additional, and Lannes-Vieira, Joseli, additional

Published
2012
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17. Chronic Trypanosoma cruzi-elicited cardiomyopathy: from the discovery to the proposal of rational therapeutic interventions targeting cell adhesion molecules and chemokine receptors - how to make a dream come true

Author

Lannes-Vieira, Joseli, primary, Silverio, Jaline Coutinho, additional, Pereira, Isabela Resende, additional, Vinagre, Nathália Ferreira, additional, Carvalho, Cristiano Marcelo Espinola, additional, Paiva, Cláudia Neto, additional, and Silva, Andréa Alice da, additional

Published
2009
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18. TNF/TNFR1 signaling up-regulates CCR5 expression by CD8+ T lymphocytes and promotes heart tissue damage during Trypanosoma cruzi infection: beneficial effects of TNF-α blockade

Author

Kroll-Palhares, Karina, primary, Silvério, Jaline Coutinho, additional, Silva, Andrea Alice da, additional, Michailowsky, Vladimir, additional, Marino, Ana Paula, additional, Silva, Neide Maria, additional, Carvalho, Cristiano Marcelo Espinola, additional, Pinto, Luzia Maria de Oliveira, additional, Gazzinelli, Ricardo Tostes, additional, and Lannes-Vieira, Joseli, additional

Published
2008
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19. CHRONIC CHAGAS’ DISEASE IN RHESUS MONKEYS (MACACA MULATTA): EVALUATION OF PARASITEMIA, SEROLOGY, ELECTROCARDIOGRAPHY, ECHOCARDIOGRAPHY, AND RADIOLOGY

Author

CARVALHO, CRISTIANO MARCELO ESPINOLA, primary, LANNES-VIEIRA, JOSELI, additional, BONECINI-ALMEIDA, MARIA DA GLÓRIA, additional, XAVIER, SÉRGIO SALLES, additional, JANSEN, ANA MARIA, additional, MANGIA, REGINA HELENA RICCIOPPO, additional, FERNANDES, OCTAVIO, additional, ANDRADE, MÁRCIA CRISTINA RIBEIRO, additional, and BRITTO, CONSTANÇA CARVALHO, additional

Published
2003
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21. Intake of Polydextrose Alters Hematology and the Profile of Short Chain Fatty Acids in Partially Gastrectomized Rats.

Author

do Carmo, Mariane Moreira Ramiro, Sarmento, Ulana Chaves, Cavalheiro, Leandro Fontoura, Fernandes, Anderson, Filiú, Wander Fernando de Oliveira, Gielow, Karine de Cássia Freitas, Costa, Deiler Sampaio, Guercio, Adriana Conceiçon, do Nascimento, Valter Aragão, Hiane, Priscila Aiko, dos Santos, Elisvânia Freitas, Ribeiro, Camila Fontoura Acosta, de Castro, Alinne Pereira, Carvalho, Cristiano Marcelo Espinola, Novello, Daiana, Santos-Junior, Valfredo de Almeida, Amaya-Farfan, Jaime, and Morato, Priscila Neder

Abstract

Polydextrose (PDX) ingestion may increase the intestinal absorption of iron. This study evaluated the effects of 7.5% polydextrose supplementation on markers of iron uptake, transport and storage in partially gastrectomized rats. Half of a batch of 40 male Wistar rats (250 g) underwent Billroth II partial gastrectomy with anterior truncal vagotomy (GXT), while the other half underwent sham gastrectomy (SHAM). At 7 postoperative days, the animals were subdivided into four groups (n = 10): Sham Control and GXT Control (no polydextrose); Sham PDX and GXT PDX (with 7.5% PDX). The animals were euthanized after 60 day of PDX treatment. Organ weight, cecal pH, the characterization and quantification of short-chain fatty acids (SCFA), hematological parameters, hepatic iron content and the expression of ferroportin (FPT) in the jejunum, cecum, colon and liver were evaluated. PDX caused changes in the cecum of the supplemented animals, where there was a decrease in pH, increase in cecal wall and marked production of SCFA, especially acetic and propionic acids (p < 0.05). Hepatic iron levels were lower in GXT animals. PDX increased hemoglobin (HGB) values by 29.2% and hematocrit (HCT) by 55.8% in the GXT PDX group compared to the GXT Control group. The GXT PDX group had lower hepatic FPT expression (p < 0.05). PDX led to increased SCFA concentration in the supplemented animals. Considering that SCFAs play a central role in the increasing nutrients uptake, this mechanism may be involved in altering the hematology profile observed in these animals but not enough to reverse iron deficiency anemia in post-gastrectomy rats. [ABSTRACT FROM AUTHOR]

Published
2018
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22. TNF/TNFR1 signaling up-regulates CCR5 expression by CD8+ T lymphocytes and promotes heart tissue damage during Trypanosoma cruzi infection: beneficial effects of TNF-alpha blockade.

Author

Kroll-Palhares K, Silvério JC, Silva AA, Michailowsky V, Marino AP, Silva NM, Carvalho CM, Pinto LM, Gazzinelli RT, and Lannes-Vieira J

Subjects
Animals, Cell Movement, Chagas Cardiomyopathy drug therapy, Chronic Disease, Female, Flow Cytometry, Immunohistochemistry, Infliximab, Mice, Mice, Inbred C57BL, RNA, Messenger biosynthesis, RNA, Messenger genetics, Receptors, Tumor Necrosis Factor, Type I blood, Receptors, Tumor Necrosis Factor, Type I immunology, Signal Transduction, Tumor Necrosis Factor-alpha blood, Tumor Necrosis Factor-alpha immunology, Anti-Inflammatory Agents pharmacology, Antibodies, Monoclonal pharmacology, CD8-Positive T-Lymphocytes immunology, Chagas Cardiomyopathy immunology, Receptors, CCR5 immunology, Receptors, Tumor Necrosis Factor, Type I antagonists & inhibitors, Tumor Necrosis Factor-alpha antagonists & inhibitors
Abstract

In Chagas disease, understanding how the immune response controls parasite growth but also leads to heart damage may provide insight into the design of new therapeutic strategies. Tumor necrosis factor-alpha (TNF-alpha) is important for resistance to acute Trypanosoma cruzi infection; however, in patients suffering from chronic T. cruzi infection, plasma TNF-alpha levels correlate with cardiomyopathy. Recent data suggest that CD8-enriched chagasic myocarditis formation involves CCR1/CCR5-mediated cell migration. Herein, the contribution of TNF-alpha, especially signaling through the receptor TNFR1/p55, to the pathophysiology of T. cruzi infection was evaluated with a focus on the development of myocarditis and heart dysfunction. Colombian strain-infected C57BL/6 mice had increased frequencies of TNFR1/p55+ and TNF-alpha+ splenocytes. Although TNFR1-/- mice exhibited reduced myocarditis in the absence of parasite burden, they succumbed to acute infection. Similar to C57BL/6 mice, Benznidazole-treated TNFR1-/- mice survived acute infection. In TNFR1-/- mice, reduced CD8-enriched myocarditis was associated with defective activation of CD44+CD62Llow/- and CCR5+ CD8+ lymphocytes. Also, anti-TNF-alpha treatment reduced the frequency of CD8+CCR5+ circulating cells and myocarditis, though parasite load was unaltered in infected C3H/HeJ mice. TNFR1-/- and anti-TNF-alpha-treated infected mice showed regular expression of connexin-43 and reduced fibronectin deposition, respectively. Furthermore, anti-TNF-alpha treatment resulted in lower levels of CK-MB, a cardiomyocyte lesion marker. Our results suggest that TNF/TNFR1 signaling promotes CD8-enriched myocarditis formation and heart tissue damage, implicating the TNF/TNFR1 signaling pathway as a potential therapeutic target for control of T. cruzi-elicited cardiomyopathy.

Published
2008
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