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234 results on '"Carulla, M."'

1. Optimizing Charge Transport Simulation for Hybrid Pixel Detectors

Author

Xie, X., Barten, R., Bergamaschi, A., Braham, B., Brückner, M., Carulla, M., Dinapoli, R., Ebner, S., Ferjaoui, K., Fröjdh, E., Greiffenberg, D., Hasanaj, S., Heymes, J., Hinger, V., King, T., Kozlowski, P., Lopez-Cuenca, C., Mezza, D., Moustakas, K., Mozzanica, A., Paton, K. A., Ruder, C., Schmitt, B., Sieberer, P., Thattil, D., and Zhang, J.

Subjects
Physics - Instrumentation and Detectors
Abstract

To enhance the spatial resolution of the M\"ONCH 25 \textmu m pitch hybrid pixel detector, deep learning models have been trained using both simulation and measurement data. Challenges arise when comparing simulation-based deep learning models to measurement-based models for electrons, as the spatial resolution achieved through simulations is notably inferior to that from measurements. Discrepancies are also observed when directly comparing X-ray simulations with measurements, particularly in the spectral output of single pixels. These observations collectively suggest that current simulations require optimization. To address this, a Monte Carlo simulation was conducted to model the dynamics of charge carriers within the silicon sensor, aiming to refine charge transport modeling. The simulation encompasses the initial generation of the charge cloud, charge cloud drift, charge diffusion and repulsion, and electronic noise. The simulation results were validated with measurements from the M\"ONCH detector for X-rays, and the agreement between measurements and simulations was significantly improved by accounting for the charge repulsion., Comment: Prepared for submission to JINST as a proceeding for 25th International Workshops on Radiation Imaging Detectors

Published
2024

2. Detection of MeV electrons using a charge integrating hybrid pixel detector

Author

Fröjdh, E., Baruffaldi, F., Bergamaschi, A., Carulla, M., Dinapoli, R., Greiffenberg, D., Heymes, J., Hinger, V., Ischebeck, R., Mathisen, S., McKenzie, J., Mezza, D., Moustakas, K., Mozzanica, A., Schmitt, B., and Zhang, J.

Subjects
Physics - Instrumentation and Detectors
Abstract

Electrons are emerging as a strong complement to X-rays for diffraction based studies. In this paper we investigate the performance of a JUNGFRAU detector with 320 um thick silicon sensor at a pulsed electron source. Originally developed for X-ray detection at free electron lasers, JUNGFRAU features a dynamic range of 120 MeV/pixel (implemented with in-pixel gain switching) which translated to about 1200 incident electrons per pixel and frame in the MeV region. We preset basic characteristics such as energy deposited per incident particle, resulting cluster size and spatial resolution along with dynamic (intensity) range scans. Measurements were performed at 4, 10 and 20 MeV/c. We compare the measurements with GEANT4 based simulations and extrapolate the results to different sensor thicknesses using these simulations.

Published
2022
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3. [Artículo traducido] Predictores de las complicaciones postoperatorias en el primer año tras la fijación de fracturas de tobillo de baja energía. Estudio de cohortes retrospectivo sobre 663 fracturas intervenidas consecutivamente en un único centro

Author

Andrés-Peiró, J.-V., Pujol, O., Altayó-Carulla, M., Castellanos-Alonso, S., Reverté-Vinaixa, M.-M., Teixidor-Serra, J., Tomàs-Hernández, J., Selga-Marsà, J., García-Sánchez, Y., Molero-García, V., Joshi-Jubert, N., and Minguell-Monyart, J.

Published
2024
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5. Inverse Low Gain Avalanche Detectors (iLGADs) for precise tracking and timing applications

Author

Currás, E., Carulla, M., Vignali, M. Centis, Duarte-Campderros, J., Fernández, M., Flores, D., García, A., Gómez, G., González, J., Hidalgo, S., Jaramillo, R., Merlos, A., Moll, M., Pellegrini, G., Quirion, D., and Vila, I.

Subjects
Physics - Instrumentation and Detectors, 14J60 (Primary) 14F05, 14J26 (Secondary)
Abstract

Low Gain Avalanche Detector (LGAD) is the baseline sensing technology of the recently proposed Minimum Ionizing Particle (MIP) end-cap timing detectors (MTD) at the Atlas and CMS experiments. The current MTD sensor is designed as a multi-pad matrix detector delivering a poor position resolution, due to the relatively large pad area, around 1 $mm^2$; and a good timing resolution, around 20-30 ps. Besides, in his current technological incarnation, the timing resolution of the MTD LGAD sensors is severely degraded once the MIP particle hits the inter-pad region since the signal amplification is missing for this region. This limitation is named as the LGAD fill-factor problem. To overcome the fill factor problem and the poor position resolution of the MTD LGAD sensors, a p-in-p LGAD (iLGAD) was introduced. Contrary to the conventional LGAD, the iLGAD has a non-segmented deep p-well (the multiplication layer). Therefore, iLGADs should ideally present a constant gain value over all the sensitive region of the device without gain drops between the signal collecting electrodes; in other words, iLGADs should have a 100${\%}$ fill-factor by design. In this paper, tracking and timing performance of the first iLGAD prototypes is presented., Comment: Conference Proceedings of VCI2019, 15th Vienna Conference of Instrumentation, February 18-22, 2019, Vienna, Austria

Published
2019
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6. Beam test measurements of Low Gain Avalanche Detector single pads and arrays for the ATLAS High Granularity Timing Detector

Author

Allaire, C., Benitez, J., Bomben, M., Calderini, G., Carulla, M., Cavallaro, E., Falou, A., Flores, D., Freeman, P., Galloway, Z., Gkougkousis, E. L., Grabas, H., Grinstein, S., Gruey, B., Guindon, S., Correia, A. M. Henriques, Hidalgo, S., Kastanas, A., Labitan, C., Lacour, D., Lange, J., Lanni, F., Lenzi, B., Luce, Z., Makovec, N., Marchiori, G., Masetti, L., Merlos, A., McKinney-Martinez, F., Nikolic-Audit, I., Pellegrini, G., Polifka, R., Quirion, D., Rummler, A., Sadrozinski, H. F-W., Seiden, A., Serin, L., Simion, S., Spencer, E., Trincaz-Duvoid, S., Wilder, M., Zatserklyaniy, A., Zerwas, D., and Zhao, Y.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

For the high luminosity upgrade of the LHC at CERN, ATLAS is considering the addition of a High Granularity Timing Detector (HGTD) in front of the end cap and forward calorimeters at |z| = 3.5 m and covering the region 2.4 < |{\eta}| < 4 to help reducing the effect of pile-up. The chosen sensors are arrays of 50 {\mu}m thin Low Gain Avalanche Detectors (LGAD). This paper presents results on single LGAD sensors with a surface area of 1.3x1.3 mm2 and arrays with 2x2 pads with a surface area of 2x2 mm^2 or 3x3 mm^2 each and different implant doses of the p+ multiplication layer. They are obtained from data collected during a beam test campaign in Autumn 2016 with a pion beam of 120 GeV energy at the CERN SPS. In addition to several quantities measured inclusively for each pad, the gain, efficiency and time resolution have been estimated as a function of the position of the incident particle inside the pad by using a beam telescope with a position resolution of few {\mu}m. Different methods to measure the time resolution are compared, yielding consistent results. The sensors with a surface area of 1.3x1.3 mm^2 have a time resolution of about 40 ps for a gain of 20 and of about 27 ps for a gain of 50 and fulfill the HGTD requirements. Larger sensors have, as expected, a degraded time resolution. All sensors show very good efficiency and time resolution uniformity.

Published
2018
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7. Radiation Hardness of Thin Low Gain Avalanche Detectors

Author

Kramberger, G., Carulla, M., Cavallaro, E., Cindro, V., Flores, D., Galloway, Z., Grinstein, S., Hidalgo, S., Fadeyev, V., Lange, J., Mandic, I., Medin, G., Merlos, A., McKinney-Martinez, F., Mikuz, M., Quirion, D., Pellegrini, G., Petek, M., Sadrozinski, H. F-W., Seiden, A., and Zavrtanik, M.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

Low Gain Avalanche Detectors (LGAD) are based on a n++-p+-p-p++ structure where an appropriate doping of the multiplication layer (p+) leads to high enough electric fields for impact ionization. Gain factors of few tens in charge significantly improve the resolution of timing measurements, particularly for thin detectors, where the timing performance was shown to be limited by Landau fluctuations. The main obstacle for their operation is the decrease of gain with irradiation, attributed to effective acceptor removal in the gain layer. Sets of thin sensors were produced by two different producers on different substrates, with different gain layer doping profiles and thicknesses (45, 50 and 80 um). Their performance in terms of gain/collected charge and leakage current was compared before and after irradiation with neutrons and pions up to the equivalent fluences of 5e15 cm-2. Transient Current Technique and charge collection measurements with LHC speed electronics were employed to characterize the detectors. The thin LGAD sensors were shown to perform much better than sensors of standard thickness (~300 um) and offer larger charge collection with respect to detectors without gain layer for fluences <2e15 cm-2. Larger initial gain prolongs the beneficial performance of LGADs. Pions were found to be more damaging than neutrons at the same equivalent fluence, while no significant difference was found between different producers. At very high fluences and bias voltages the gain appears due to deep acceptors in the bulk, hence also in thin standard detectors.

Published
2017
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8. Gain and time resolution of 45 $\mu$m thin Low Gain Avalanche Detectors before and after irradiation up to a fluence of $10^{15}$ n$_{eq}$/cm$^2$

Author

Lange, J., Carulla, M., Cavallaro, E., Chytka, L., Davis, P. M., Flores, D., Förster, F., Grinstein, S., Hidalgo, S., Komarek, T., Kramberger, G., Mandić, I., Merlos, A., Nozka, L., Pellegrini, G., Quirion, D., and Sykora, T.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

Low Gain Avalanche Detectors (LGADs) are silicon sensors with a built-in charge multiplication layer providing a gain of typically 10 to 50. Due to the combination of high signal-to-noise ratio and short rise time, thin LGADs provide good time resolutions. LGADs with an active thickness of about 45 $\mu$m were produced at CNM Barcelona. Their gains and time resolutions were studied in beam tests for two different multiplication layer implantation doses, as well as before and after irradiation with neutrons up to $10^{15}$ n$_{eq}$/cm$^2$. The gain showed the expected decrease at a fixed voltage for a lower initial implantation dose, as well as for a higher fluence due to effective acceptor removal in the multiplication layer. Time resolutions below 30 ps were obtained at the highest applied voltages for both implantation doses before irradiation. Also after an intermediate fluence of $3\times10^{14}$ n$_{eq}$/cm$^2$, similar values were measured since a higher applicable reverse bias voltage could recover most of the pre-irradiation gain. At $10^{15}$ n$_{eq}$/cm$^2$, the time resolution at the maximum applicable voltage of 620 V during the beam test was measured to be 57 ps since the voltage stability was not good enough to compensate for the gain layer loss. The time resolutions were found to follow approximately a universal function of gain for all implantation doses and fluences., Comment: 17 pages

Published
2017
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9. 3D sensors for the HL-LHC

Author

Furelos, D. Vázquez, Carulla, M., Cavallaro, E., Förster, F., Grinstein, S., Lange, J., Paz, I. López, Manna, M., Pellegrini, G., Quirion, D., and Terzo, S.

Subjects
Physics - Instrumentation and Detectors
Abstract

In order to increase its discovery potential, the Large Hadron Collider (LHC) accelerator will be upgraded in the next decade. The high luminosity LHC (HL-LHC) period demands new sensor technologies to cope with increasing radiation fluences and particle rates. The ATLAS experiment will replace the entire inner tracking detector with a completely new silicon-only system. 3D pixel sensors are promising candidates for the innermost layers of the Pixel detector due to their excellent radiation hardness at low operation voltages and low power dissipation at moderate temperatures. Recent developments of 3D sensors for the HL-LHC are presented., Comment: 8 pages, 5 figures, International Workshops on Radiation Imaging Detectors 2016

Published
2016
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10. Balancing gain and dynamic range in a 25 µm pitch hybrid pixel detector

Author

Heymes, J., primary, Barten, R., additional, Baruffaldi, F., additional, Bergamaschi, A., additional, Brückner, M., additional, Carulla, M., additional, Dinapoli, R., additional, Ebner, S., additional, Fröjdh, E., additional, Greiffenberg, D., additional, Hasanaj, S., additional, Hinger, V., additional, King, T., additional, Kozłowski, P., additional, Lopez-Cuenca, C., additional, Mezza, D., additional, Moustakas, K., additional, Mozzanica, A., additional, Paton, K.A., additional, Ruder, C., additional, Schmitt, B., additional, Thattil, D., additional, Xie, X., additional, and Zhang, J., additional

Published
2024
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11. Beam test results of a 16 ps timing system based on ultra-fast silicon detectors

Author

Cartiglia, N., Staiano, A., Sola, V., Arcidiacono, R., Cirio, R., Cenna, F., Ferrero, M., Monaco, V., Mulargia, R., Obertino, M., Ravera, F., Sacchi, R., Bellora, A., Durando, S., Mandurrino, M., Minafra, N., Fadeyev, V., Freeman, P., Galloway, Z., Gkougkousis, E., Grabas, H., Gruey, B., Labitan, C. A., Losakul, R., Luce, Z., McKinney-Martinez, F., Sadrozinski, H. F. -W., Seiden, A., Spencer, E., Wilder, M., Woods, N., Zatserklyaniy, A., Pellegrini, G., Hidalgo, S., Carulla, M., Flores, D., Merlos, A., Quirion, D., Cindro, V., Kramberger, G., Mandic, I., Mikuz, M., and Zavrtanik, M.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

In this paper we report on the timing resolution of the first production of 50 micro-meter thick Ultra-Fast Silicon Detectors (UFSD) as obtained in a beam test with pions of 180 GeV/c momentum. UFSD are based on the Low-Gain Avalanche Detectors (LGAD) design, employing n-on-p silicon sensors with internal charge multiplication due to the presence of a thin, low-resistivity diffusion layer below the junction. The UFSD used in this test belongs to the first production of thin (50 {\mu}m) sensors, with an pad area of 1.4 mm2. The gain was measured to vary between 5 and 70 depending on the bias voltage. The experimental setup included three UFSD and a fast trigger consisting of a quartz bar readout by a SiPM. The timing resolution, determined comparing the time of arrival of the particle in one or more UFSD and the trigger counter, for single UFSD was measured to be 35 ps for a bias voltage of 200 V, and 26 ps for a bias voltage of 240 V, and for the combination of 3 UFSD to be 20 ps for a bias voltage of 200 V, and 15 ps for a bias voltage of 240 V., Comment: 7 pages, 8 figures, 1 table, Subm. to NIM A

Published
2016
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12. Recent Technological Developments on LGAD and iLGAD Detectors for Tracking and Timing Applications

Author

Pellegrini, G., Baselga, M., Carulla, M., Fadeyev, V., Fernandez-Martinez, P., Fernandez-Garcia, M., Flores, D., Galloway, Z., Gallrapp, C., Hidalgo, S., Liang, Z., Merlos, A., Moll, M., Quirion, D., Sadrozinski, H., Stricker, M., and Vila, I.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

This paper reports the last technological development on the Low Gain Avalanche Detector (LGAD) and introduces a new architecture of these detectors called inverse-LGAD (iLGAD). Both approaches are based on the standard Avalanche Photo Diodes (APD) concept, commonly used in optical and X-ray detection applications, including an internal multiplication of the charge generated by radiation. The multiplication is inherent to the basic n++-p+-p structure, where the doping profile of the p+ layer is optimized to achieve high field and high impact ionization at the junction. The LGAD structures are optimized for applications such as tracking or timing detectors for high energy physics experiments or medical applications where time resolution lower than 30 ps is required. Detailed TCAD device simulations together with the electrical and charge collection measurements are presented through this work., Comment: Keywords: silicon detectors, avalanche multiplication, timing detectors, tracking detectors. 8 pages. 8 Figures

Published
2015
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15. High-Z sensors for synchrotron sources and FELs

Author

Greiffenberg, D., primary, Baruffaldi, F., additional, Bergamaschi, A., additional, Carulla, M., additional, Dinapoli, R., additional, Fröjdh, E., additional, Heymes, J., additional, Hinger, V., additional, Mezza, D., additional, Moustakas, K., additional, Mozzanica, A., additional, Paton, K. A., additional, Schmitt, B., additional, Xie, X., additional, and Zhang, J., additional

Published
2023
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16. The new Matterhorn detector for 4th generation synchrotrons

Author

Mezza, D., primary, Barten, R., additional, Baruffaldi, F., additional, Bergamaschi, A., additional, Brueckner, M., additional, Carulla, M., additional, Dinapoli, R., additional, Ebner, S., additional, Froejd, E., additional, Greiffenberg, D., additional, Hasanaj, S., additional, Heymes, J., additional, Hinger, V., additional, King, T., additional, Kozlowski, P., additional, Lopez-Cuenca, C., additional, Mozzanica, A., additional, Moustakas, K., additional, Paton, K. A., additional, Ruder, C., additional, Schmitt, B., additional, Thattil, D., additional, Xie, X., additional, and Zhang, J., additional

Published
2023
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18. Radiation hardness of gallium doped low gain avalanche detectors

Author

Kramberger, G., Carulla, M., Cavallaro, E., Cindro, V., Flores, D., Galloway, Z., Grinstein, S., Hidalgo, S., Fadeyev, V., Lange, J., Mandić, I., Merlos, A., McKinney-Martinez, F., Mikuž, M., Quirion, D., Pellegrini, G., Petek, M., Sadrozinski, H.F.-W., Seiden, A., and Zavrtanik, M.

Published
2018
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19. Studies of uniformity of 50 [formula omitted]m low-gain avalanche detectors at the Fermilab test beam

Author

Apresyan, A., Xie, S., Pena, C., Arcidiacono, R., Cartiglia, N., Carulla, M., Derylo, G., Ferrero, M., Flores, D., Freeman, P., Galloway, Z., Ghassemi, A., Al Ghoul, H., Gray, L., Hidalgo, S., Kamada, S., Los, S., Mandurrino, M., Merlos, A., Minafra, N., Pellegrini, G., Quirion, D., Ronzhin, A., Royon, C., Sadrozinski, H., Seiden, A., Sola, V., Spiropulu, M., Staiano, A., Uplegger, L., Yamamoto, K., and Yamamura, K.

Published
2018
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20. Radiation hardness of thin Low Gain Avalanche Detectors

Author

Kramberger, G., Carulla, M., Cavallaro, E., Cindro, V., Flores, D., Galloway, Z., Grinstein, S., Hidalgo, S., Fadeyev, V., Lange, J., Mandić, I., Medin, G., Merlos, A., McKinney-Martinez, F., Mikuž, M., Quirion, D., Pellegrini, G., Petek, M., Sadrozinski, H.F.-W., Seiden, A., and Zavrtanik, M.

Published
2018
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23. Geographical variability in survival of European children with central nervous system tumours

Author

Hackl, M., Zielonke, N., Oberaigner, W., Van Eycken, E., Henau, K., Valerianova, Z., Dimitrova, N., Sekerija, M., Storm, H., Engholm, G., Mägi, M., Aareleid, T., Malila, N., Seppä, K., Faivre, J., Bossard, N., Uhry, Z., Colonna, M., Clavel, J., Lacour, B., Desandes, E., Brenner, H., Kaatsch, P., Katalinic, A., Garami, M., Jakab, Z., Comber, H., Mazzoleni, G., Bulatko, A., Buzzoni, C., Giacomin, A., Sutera Sardo, A., Mancuso, P., Ferretti, S., Barchielli, A., Caldarella, A., Gatta, G., Sant, M., Amash, H., Amati, C., Baili, P., Berrino, F., Bonfarnuzzo, S., Botta, L., Capocaccia, R., Di Salvo, F., Foschi, R., Margutti, C., Meneghini, E., Minicozzi, P., Trama, A., Serraino, D., Zucchetto, A., De Angelis, R., Caldora, M., Carrani, E., Francisci, S., Mallone, S., Pierannunzio, D., Roazzi, P., Rossi, S., Santaquilani, M., Tavilla, A., Pannozzo, F., Busco, S., Filiberti, R.A., Marani, E., Ricci, P., Pascucci, C., Autelitano, M., Spagnoli, G., Cirilli, C., Fusco, M., Vitale, M.F., Usala, M., Vitale, F., Ravazzolo, B., Michiara, M., Merletti, F., Maule, M., Tumino, R., Mangone, L., Di Felice, E., Falcini, F., Iannelli, A., Sechi, O., Cesaraccio, R., Piffer, S., Madeddu, A., Tisano, F., Maspero, S., Fanetti, A.C., Candela, P., Scuderi, T., Stracci, F., Bianconi, F., Tagliabue, G., Contiero, P., Rugge, M., Guzzinati, S., Pildava, S., Smailyte, G., Calleja, N., Agius, D., Johannesen, T.B., Rachtan, J., Góźdź, S., Mężyk, R., Błaszczyk, J., Bębenek, M., Bielska-Lasota, M., Forjaz de Lacerda, G., Bento, M.J., Castro, C., Miranda, A., Mayer-da-Silva, A., Safaei Diba, C., Primic-Zakelj, M., Errezola, M., Bidaurrazaga, J., Vicente Raneda, M., Díaz García, J.M., Marcos-Navarro, A.I., Marcos-Gragera, R., Izquierdo Font, A., Sanchez, M.J., Chang, D.Y.L., Navarro, C., Chirlaque, M.D., Moreno-Iribas, C., Ardanaz, E., Peris-Bonet, R., Pardo Romaguera, E., Galceran, J., Carulla, M., Lambe, M., Mousavi, M., Bouchardy, C., Usel, M., Ess, S.M., Frick, H., Lorez, M., Herrmann, C., Bordoni, A., Spitale, A., Konzelmann, I., Visser, O., Aarts, M., Otter, R., Coleman, M., Allemani, C., Rachet, B., Verne, J., Stiller, C., Gavin, A., Donnelly, C., Brewster, D.H., Sánchez, M.-J., and Rutkowski, S.

Published
2017
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24. Ten-Year Probabilities of Death Due to Cancer and Cardiovascular Disease among Breast Cancer Patients Diagnosed in North-Eastern Spain

Author

Universitat Rovira i Virgili, Clèries R; Ameijide A; Buxó M; Vilardell M; Martínez JM; Font R; Marcos-Gragera R; Puigdemont M; Viñas G; Carulla M; Espinàs JA; Galceran J; Izquierdo Á; Borràs JM, Universitat Rovira i Virgili, and Clèries R; Ameijide A; Buxó M; Vilardell M; Martínez JM; Font R; Marcos-Gragera R; Puigdemont M; Viñas G; Carulla M; Espinàs JA; Galceran J; Izquierdo Á; Borràs JM

Abstract

Mortality from cardiovascular disease (CVD), second tumours, and other causes is of clinical interest in the long-term follow-up of breast cancer (BC) patients. Using a cohort of BC patients (N = 6758) from the cancer registries of Girona and Tarragona (north-eastern Spain), we studied the 10-year probabilities of death due to BC, other cancers, and CVD according to stage at diagnosis and hormone receptor (HR) status. Among the non-BC causes of death (N = 720), CVD (N = 218) surpassed other cancers (N = 196). The BC cohort presented a significantly higher risk of death due to endometrial and ovarian cancers than the general population. In Stage I, HR− patients showed a 1.72-fold higher probability of all-cause death and a 6.11-fold higher probability of breast cancer death than HR+ patients. In Stages II–III, the probability of CVD death (range 3.11% to 3.86%) surpassed that of other cancers (range 0.54% to 3.11%). In Stage IV patients, the probability of death from any cancer drove the mortality risk. Promoting screening and preventive measures in BC patients are warranted, since long-term control should encompass early detection of second neoplasms, ruling out the possibility of late recurrence. In patients diagnosed in Stages II–III at an older age, surveillance for preventing late cardiotoxicity is crucial.

Published
2023

25. Survival of 86,690 patients with thyroid cancer: A population-based study in 29 European countries from EUROCARE-5

Author

Hackl, M., Zielonke, N., Van Eycken, E., Henau, K., Valerianova, Z., Dimitrova, N., Sekerija, M., Dušek, L., Zvolský, M., Storm, H., Engholm, G., Mägi, M., Aareleid, T., Malila, N., Seppä, K., Velten, M., Guizard, A.V., Faivre, J., Woronoff, A.S., Tretarre, B., Bossard, N., Uhry, Z., Colonna, M., Molinié, F., Bara, S., Schvartz, C., Lapôtre-Ledoux, B., Grosclaude, P., Stabenow, R., Luttmann, S., Eberle, A., Brenner, H., Nennecke, A., Engel, J., Schubert-Fritschle, G., Heidrich, J., Holleczek, B., Katalinic, A., Jónasson, J.G., Tryggvadóttir, L., Comber, H., Mazzoleni, G., Bulatko, A., Buzzoni, C., Giacomin, A., Sutera Sardo, A., Mazzei, A., Ferretti, S., Barchielli, A., Caldarella, A., Gatta, G., Sant, M., Amash, H., Amati, C., Baili, P., Berrino, F., Bonfarnuzzo, S., Botta, L., Capocaccia, R., Di Salvo, F., Foschi, R., Margutti, C., Meneghini, E., Minicozzi, P., Trama, A., Serraino, D., Zucchetto, A., De Angelis, R., Caldora, M., Carrani, E., Francisci, S., Mallone, S., Pierannunzio, D., Roazzi, P., Rossi, S., Santaquilani, M., Tavilla, A., Pannozzo, F., Busco, S., Filiberti, R.A., Vercelli, M., Ricci, P., Autelitano, M., Spagnoli, G., Cirilli, C., Fusco, M., Vitale, M.F., Usala, M., Vitale, F., Ravazzolo, B., Michiara, M., Tumino, R., Mangone, L., Vicentini, M., Falcini, F., Iannelli, A., Sechi, O., Cesaraccio, R., Piffer, S., Madeddu, A., Tisano, F., Maspero, S., Fanetti, A.C., Zanetti, R., Rosso, S., Candela, P., Scuderi, T., Stracci, F., Rocca, A., Tagliabue, G., Contiero, P., Rugge, M., Tognazzo, S., Pildava, S., Smailyte, G., Calleja, N., Agius, D., Johannesen, T.B., Rachtan, J., Góźdź, S., Mężyk, R., Błaszczyk, J., Bębenek, M., Bielska-Lasota, M., Forjaz de Lacerda, G., Bento, M.J., Castro, C., Miranda, A., Mayer-da-Silva, A., Safaei Diba, C., Primic-Zakelj, M., Errezola, M., Bidaurrazaga, J., Díaz García, J.M., Marcos-Navarro, A.I., Marcos-Gragera, R., Izquierdo Font, A., Sanchez, M.J., Molina, E., Navarro, C., Chirlaque, M.D., Moreno-Iribas, C., Ardanaz, E., Galceran, J., Carulla, M., Lambe, M., Khan, S., Mousavi, M., Bouchardy, C., Usel, M., Ess, S.M., Frick, H., Lorez, M., Herrmann, C., Bordoni, A., Spitale, A., Konzelmann, I., Visser, O., Ho, V., Otter, R., Coleman, M., Allemani, C., Rachet, B., Rashbass, J., Broggio, J., Verne, J., Gavin, A., Donnelly, C., Brewster, D.H., Huws, D.W., White, C., Dal Maso, L., Pacini, F., van Dijk, B.A.C., Larrañaga, N., Rubió-Casadevall, J., Kowalska, A., and Virdone, S.

Published
2017
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26. Long-term survival and cure fraction estimates for childhood cancer in Europe (EUROCARE-6): results from a population-based study

Author

Botta, L, Gatta, G, Capocaccia, R, Stiller, C, Canete, A, Dal Maso, L, Innos, K, Mihor, A, Erdmann, F, Spix, C, Lacour, B, Marcos-Gragera, R, Murray, D, Rossi, S, Hackl, M, Van Eycken, E, Van Damme, N, Valerianova, Z, Sekerija, M, Scoutellas, V, Demetriou, A, Dusek, L, Krejci, D, Storm, H, Magi, M, Paapsi, K, Malila, N, Pitkaniemi, J, Jooste, V, Clavel, J, Poulalhon, C, Desandes, E, Monnereau, A, Katalinic, A, Petridou, E, Markozannes, G, Garami, M, Birgisson, H, Walsh, P, Mazzoleni, G, Vittadello, F, Cuccaro, F, Galasso, R, Sampietro, G, Rosso, S, Gasparotto, C, Maifredi, G, Ferrante, M, Torrisi, A, Sutera Sardo, A, Gambino, M, Lanzoni, M, Ballotari, P, Giacomazzi, E, Ferretti, S, Caldarella, A, Manneschi, G, Sant, M, Baili, P, Berrino, F, Trama, A, Lillini, R, Bernasconi, A, Bonfarnuzzo, S, Vener, C, Didone, F, Lasalvia, P, Del Monego, G, Buratti, L, Serraino, D, Taborelli, M, De Angelis, R, Demuru, E, Di Benedetto, C, Santaquilani, M, Venanzi, S, Tallon, M, Boni, L, Iacovacci, S, Russo, A, Gervasi, F, Spagnoli, G, Cavalieri d'Oro, L, Fusco, M, Vitale, M, Usala, M, Vitale, F, Michiara, M, Chiranda, G, Sacerdote, C, Maule, M, Cascone, G, Spata, E, Mangone, L, Falcini, F, Cavallo, R, Piras, D, Dinaro, Y, Castaing, M, Fanetti, A, Minerba, S, Candela, G, Scuderi, T, Rizzello, R, Stracci, F, Tagliabue, G, Rugge, M, Brustolin, A, Pildava, S, Smailyte, G, Azzopardi, M, Johannesen, T, Didkowska, J, Wojciechowska, U, Bielska-Lasota, M, Pais, A, Ferreira, A, Bento, M, Miranda, A, Safaei Diba, C, Zadnik, V, Zagar, T, Sanchez-Contador Escudero, C, Franch Sureda, P, Lopez de Munain, A, De-La-Cruz, M, Rojas, M, Aleman, A, Vizcaino, A, Almela, F, Sanvisens, A, Sanchez, M, Chirlaque, M, Sanchez-Gil, A, Guevara, M, Ardanaz, E, Canete-Nieto, A, Peris-Bonet, R, Galceran, J, Carulla, M, Kuehni, C, Redmond, S, Visser, O, Karim-Kos, H, Stevens, S, Gavin, A, Morrison, D, Huws, D, Botta L., Gatta G., Capocaccia R., Stiller C., Canete A., Dal Maso L., Innos K., Mihor A., Erdmann F., Spix C., Lacour B., Marcos-Gragera R., Murray D., Rossi S., Hackl M., Van Eycken E., Van Damme N., Valerianova Z., Sekerija M., Scoutellas V., Demetriou A., Dusek L., Krejci D., Storm H., Magi M., Paapsi K., Malila N., Pitkaniemi J., Jooste V., Clavel J., Poulalhon C., Desandes E., Monnereau A., Katalinic A., Petridou E., Markozannes G., Garami M., Birgisson H., Walsh P. M., Mazzoleni G., Vittadello F., Cuccaro F., Galasso R., Sampietro G., Rosso S., Gasparotto C., Maifredi G., Ferrante M., Torrisi A., Sutera Sardo A., Gambino M. L., Lanzoni M., Ballotari P., Giacomazzi E., Ferretti S., Caldarella A., Manneschi G., Sant M., Baili P., Berrino F., Trama A., Lillini R., Bernasconi A., Bonfarnuzzo S., Vener C., Didone F., Lasalvia P., Del Monego G., Buratti L., Serraino D., Taborelli M., De Angelis R., Demuru E., Di Benedetto C., Santaquilani M., Venanzi S., Tallon M., Boni L., Iacovacci S., Russo A. G., Gervasi F., Spagnoli G., Cavalieri d'Oro L., Fusco M., Vitale M. F., Usala M., Vitale F., Michiara M., Chiranda G., Sacerdote C., Maule M., Cascone G., Spata E., Mangone L., Falcini F., Cavallo R., Piras D., Dinaro Y., Castaing M., Fanetti A. C., Minerba S., Candela G., Scuderi T., Rizzello R. V., Stracci F., Tagliabue G., Rugge M., Brustolin A., Pildava S., Smailyte G., Azzopardi M., Johannesen T. B., Didkowska J., Wojciechowska U., Bielska-Lasota M., Pais A., Ferreira A. M., Bento M. J., Miranda A., Safaei Diba C., Zadnik V., Zagar T., Sanchez-Contador Escudero C., Franch Sureda P., Lopez de Munain A., De-La-Cruz M., Rojas M. D., Aleman A., Vizcaino A., Almela F., Sanvisens A., Sanchez M. J., Chirlaque M. D., Sanchez-Gil A., Guevara M., Ardanaz E., Canete-Nieto A., Peris-Bonet R., Galceran J., Carulla M., Kuehni C., Redmond S., Visser O., Karim-Kos H., Stevens S., Gavin A., Morrison D., Huws D. W., Botta, L, Gatta, G, Capocaccia, R, Stiller, C, Canete, A, Dal Maso, L, Innos, K, Mihor, A, Erdmann, F, Spix, C, Lacour, B, Marcos-Gragera, R, Murray, D, Rossi, S, Hackl, M, Van Eycken, E, Van Damme, N, Valerianova, Z, Sekerija, M, Scoutellas, V, Demetriou, A, Dusek, L, Krejci, D, Storm, H, Magi, M, Paapsi, K, Malila, N, Pitkaniemi, J, Jooste, V, Clavel, J, Poulalhon, C, Desandes, E, Monnereau, A, Katalinic, A, Petridou, E, Markozannes, G, Garami, M, Birgisson, H, Walsh, P, Mazzoleni, G, Vittadello, F, Cuccaro, F, Galasso, R, Sampietro, G, Rosso, S, Gasparotto, C, Maifredi, G, Ferrante, M, Torrisi, A, Sutera Sardo, A, Gambino, M, Lanzoni, M, Ballotari, P, Giacomazzi, E, Ferretti, S, Caldarella, A, Manneschi, G, Sant, M, Baili, P, Berrino, F, Trama, A, Lillini, R, Bernasconi, A, Bonfarnuzzo, S, Vener, C, Didone, F, Lasalvia, P, Del Monego, G, Buratti, L, Serraino, D, Taborelli, M, De Angelis, R, Demuru, E, Di Benedetto, C, Santaquilani, M, Venanzi, S, Tallon, M, Boni, L, Iacovacci, S, Russo, A, Gervasi, F, Spagnoli, G, Cavalieri d'Oro, L, Fusco, M, Vitale, M, Usala, M, Vitale, F, Michiara, M, Chiranda, G, Sacerdote, C, Maule, M, Cascone, G, Spata, E, Mangone, L, Falcini, F, Cavallo, R, Piras, D, Dinaro, Y, Castaing, M, Fanetti, A, Minerba, S, Candela, G, Scuderi, T, Rizzello, R, Stracci, F, Tagliabue, G, Rugge, M, Brustolin, A, Pildava, S, Smailyte, G, Azzopardi, M, Johannesen, T, Didkowska, J, Wojciechowska, U, Bielska-Lasota, M, Pais, A, Ferreira, A, Bento, M, Miranda, A, Safaei Diba, C, Zadnik, V, Zagar, T, Sanchez-Contador Escudero, C, Franch Sureda, P, Lopez de Munain, A, De-La-Cruz, M, Rojas, M, Aleman, A, Vizcaino, A, Almela, F, Sanvisens, A, Sanchez, M, Chirlaque, M, Sanchez-Gil, A, Guevara, M, Ardanaz, E, Canete-Nieto, A, Peris-Bonet, R, Galceran, J, Carulla, M, Kuehni, C, Redmond, S, Visser, O, Karim-Kos, H, Stevens, S, Gavin, A, Morrison, D, Huws, D, Botta L., Gatta G., Capocaccia R., Stiller C., Canete A., Dal Maso L., Innos K., Mihor A., Erdmann F., Spix C., Lacour B., Marcos-Gragera R., Murray D., Rossi S., Hackl M., Van Eycken E., Van Damme N., Valerianova Z., Sekerija M., Scoutellas V., Demetriou A., Dusek L., Krejci D., Storm H., Magi M., Paapsi K., Malila N., Pitkaniemi J., Jooste V., Clavel J., Poulalhon C., Desandes E., Monnereau A., Katalinic A., Petridou E., Markozannes G., Garami M., Birgisson H., Walsh P. M., Mazzoleni G., Vittadello F., Cuccaro F., Galasso R., Sampietro G., Rosso S., Gasparotto C., Maifredi G., Ferrante M., Torrisi A., Sutera Sardo A., Gambino M. L., Lanzoni M., Ballotari P., Giacomazzi E., Ferretti S., Caldarella A., Manneschi G., Sant M., Baili P., Berrino F., Trama A., Lillini R., Bernasconi A., Bonfarnuzzo S., Vener C., Didone F., Lasalvia P., Del Monego G., Buratti L., Serraino D., Taborelli M., De Angelis R., Demuru E., Di Benedetto C., Santaquilani M., Venanzi S., Tallon M., Boni L., Iacovacci S., Russo A. G., Gervasi F., Spagnoli G., Cavalieri d'Oro L., Fusco M., Vitale M. F., Usala M., Vitale F., Michiara M., Chiranda G., Sacerdote C., Maule M., Cascone G., Spata E., Mangone L., Falcini F., Cavallo R., Piras D., Dinaro Y., Castaing M., Fanetti A. C., Minerba S., Candela G., Scuderi T., Rizzello R. V., Stracci F., Tagliabue G., Rugge M., Brustolin A., Pildava S., Smailyte G., Azzopardi M., Johannesen T. B., Didkowska J., Wojciechowska U., Bielska-Lasota M., Pais A., Ferreira A. M., Bento M. J., Miranda A., Safaei Diba C., Zadnik V., Zagar T., Sanchez-Contador Escudero C., Franch Sureda P., Lopez de Munain A., De-La-Cruz M., Rojas M. D., Aleman A., Vizcaino A., Almela F., Sanvisens A., Sanchez M. J., Chirlaque M. D., Sanchez-Gil A., Guevara M., Ardanaz E., Canete-Nieto A., Peris-Bonet R., Galceran J., Carulla M., Kuehni C., Redmond S., Visser O., Karim-Kos H., Stevens S., Gavin A., Morrison D., and Huws D. W.

Abstract

Background: The EUROCARE-5 study revealed disparities in childhood cancer survival among European countries, giving rise to important initiatives across Europe to reduce the gap. Extending its representativeness through increased coverage of eastern European countries, the EUROCARE-6 study aimed to update survival progress across countries and years of diagnosis and provide new analytical perspectives on estimates of long-term survival and the cured fraction of patients with childhood cancer. Methods: In this population-based study, we analysed 135 847 children (aged 0–14 years) diagnosed during 2000–13 and followed up to the end of 2014, recruited from 80 population-based cancer registries in 31 European countries. We calculated age-adjusted 5-year survival differences by country and over time using period analysis, for all cancers combined and for major cancer types. We applied a variant of standard mixture cure models for survival data to estimate the cure fraction of patients by childhood cancer and to estimate projected 15-year survival. Findings: 5-year survival for all childhood cancer combined in Europe in 2010–14 was 81% (95% CI 81–82), showing an increase of three percentage points compared with 2004–06. Significant progress over time was observed for almost all cancers. Survival remained stable for osteosarcomas, Ewing sarcoma, Burkitt lymphoma, non-Hodgkin lymphomas, and rhabdomyoscarcomas. For all cancers combined, inequalities still persisted among European countries (with age-adjusted 5-year survival ranging from 71% [95% CI 60–79] to 87% [77–93]). The 15-year survival projection for all patients with childhood cancer diagnosed in 2010–13 was 78%. We estimated the yearly long-term mortality rate due to causes other than the diagnosed cancer to be around 2 per 1000 patients for all childhood cancer combined, but to approach zero for retinoblastoma. The cure fraction for patients with childhood cancer increased over time from 74% (95% CI 73–75) in 1998–

Published
2022

28. Study of the internal quantum efficiency of FBK sensors with optimized entrance windows

Author

Carulla, M., primary, Centis Vignali, M., additional, Barten, R., additional, Baruffaldi, F., additional, Bergamaschi, A., additional, Borghi, G., additional, Boscardin, M., additional, Brückner, M., additional, Dinapoli, R., additional, Ebner, S., additional, Ficorella, F., additional, Fröjd, E., additional, Greiffenberg, D., additional, Hammad Ali, O., additional, Hasanaj, S., additional, Heymes, J., additional, Hinger, V., additional, King, T., additional, Kozlowski, P., additional, Lopez Cuenca, C., additional, Mezza, D., additional, Moustakas, K., additional, Mozzanica, A., additional, Paternoster, G., additional, Ronchin, S., additional, Ruder, C., additional, Schmitt, B., additional, Thattil, D., additional, and Zhang, J., additional

Published
2023
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30. Ultra-fast silicon detectors (UFSD)

Author

Sadrozinski, H.F.-W., Anker, A., Chen, J., Fadeyev, V., Freeman, P., Galloway, Z., Gruey, B., Grabas, H., John, C., Liang, Z., Losakul, R., Mak, S.N., Ng, C.W., Seiden, A., Woods, N., Zatserklyaniy, A., Baldassarri, B., Cartiglia, N., Cenna, F., Ferrero, M., Pellegrini, G., Hidalgo, S., Baselga, M., Carulla, M., Fernandez-Martinez, P., Flores, D., Merlos, A., Quirion, D., Mikuž, M., Kramberger, G., Cindro, V., Mandić, I., and Zavrtanik, M.

Published
2016
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31. Detection of MeV electrons using a charge integrating hybrid pixel detector

Author

Fröjdh, E., primary, Baruffaldi, F., additional, Bergamaschi, A., additional, Carulla, M., additional, Dinapoli, R., additional, Greiffenberg, D., additional, Heymes, J., additional, Hinger, V., additional, Ischebeck, R., additional, Mathisen, S., additional, McKenzie, J., additional, Mezza, D., additional, Moustakas, K., additional, Mozzanica, A., additional, Schmitt, B., additional, and Zhang, J., additional

Published
2022
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32. First demonstration of on-chip interpolation using a single photon counting microstrip detector

Author

Bergamaschi, A., primary, Andrä, M., additional, Barten, R., additional, Baruffaldi, F., additional, Brückner, M., additional, Carulla, M., additional, Chiriotti, S., additional, Dinapoli, R., additional, Fröjdh, E., additional, Greiffenberg, D., additional, Hasanaj, S., additional, Heymes, J., additional, Hinger, V., additional, Kozlowski, P., additional, Cuenca, C.L., additional, Mezza, D., additional, Mozzanica, A., additional, Moustakas, K., additional, Ruder, C., additional, Schmitt, B., additional, Thattil, D., additional, and Zhang, J., additional

Published
2022
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33. Development of LGAD sensors with a thin entrance window for soft X-ray detection

Author

Zhang, J., primary, Barten, R., additional, Baruffaldi, F., additional, Bergamaschi, A., additional, Borghi, G., additional, Boscardin, M., additional, Brückner, M., additional, Carulla, M., additional, Centis Vignali, M., additional, Dinapoli, R., additional, Ebner, S., additional, Ficorella, F., additional, Fröjj¨dh, E., additional, Greiffenberg, D., additional, Hammad Ali, O., additional, Heymes, J., additional, Hasanaj, S., additional, Hinger, V., additional, King, T., additional, Kozlowski, P., additional, Lopez-Cuenca, C., additional, Mezza, D., additional, Moustakas, K., additional, Mozzanica, A., additional, Paternoster, G., additional, Ronchin, S., additional, Ruder, C., additional, Schmitt, B., additional, and Thattil, D., additional

Published
2022
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34. Cancer incidence in Spain, 2015

Author

Galceran, J., Ameijide, A., Carulla, M., Mateos, A., Quirós, J. R., Rojas, D., Alemán, A., Torrella, A., Chico, M., Vicente, M., Díaz, J. M., Larrañaga, N., Marcos-Gragera, R., Sánchez, M. J., Perucha, J., Franch, P., Navarro, C., Ardanaz, E., Bigorra, J., Rodrigo, P., Bonet, R. Peris, Mateos, Antonio, Almar, Enrique, Quirós, José Ramón, Argüelles, Marcial V., Rojas, Dolores, Alemán, Araceli, Torrella, Ana, Sabater, Consol, Botella, Paloma, Chico, Matilde, Ripoll, María, Díaz, Cristina, Vicente, Marisa, Fuster, Nieves, Díaz, José María, Jiménez, Rosario, Navarro, Ana Isabel Marcos, Larrañaga, Nerea, Bidaurrazaga, Joseba, Lopez-de-Munain, Arantza, Marcos-Gragera, Rafael, Izquierdo, Àngel, Vilardell, Loreto, Sánchez, María José, Molina-Portillo, Elena, Rodríguez-Barranco, Miguel, Perucha, Josefina, Franch, Paula, Ramos, Maria, Navarro, Carmen, Chirlaque, María Dolores, Salmerón, Diego, Ardanaz, Eva, Guevara, Marcela, Burgui, Rosana, Galceran, Jaume, Ameijide, Alberto, Carulla, Marià, Bigorra, Jàmnica, Bonet, Rafael Peris, Pardo, Elena, and REDECAN Working Group

Published
2017
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35. Clear Improvement in Real-World Chronic Myeloid Leukemia Survival: A Comparison With Randomized Controlled Trials

Author

Vener, C., Rossi, S., Minicozzi, P., Marcos-Gragera, R., Poirel, H. A., Maynadie, M., Troussard, X., Pravettoni, G., De Angelis, R., Sant, M., Hackl, M., Van Eycken, E., Valerianova, Z., Sekerija, M., Pavlou, P., Dusek, L., Storm, H., Magi, M., Innos, K., Malila, N., Pitkaniemi, J., Velten, M., Bouvier, A. M., Jooste, V., Guizard, A. V., Launoy, G., Yonli, S. D., Woronoff, A. S., Nousbaum, J. B., Coureau, G., Monnereau, A., Baldi, I., Hammas, K., Tretarre, B., Colonna, M., Plouvier, S., D'Almeida, T., Molinie, F., Cowppli-Bony, A., Bara, S., Schvartz, C., Defossez, G., Lapotre-Ledoux, B., Grosclaude, P., Luttmann, S., Stabenow, R., Nennecke, A., Kieschke, J., Zeissig, S., Holleczek, B., Katalinic, A., Birgisson, H., Murray, D., Walsh, P. M., Mazzoleni, G., Vittadello, F., Cuccaro, F., Galasso, R., Sampietro, G., Rosso, S., Magoni, M., Ferrante, M., Sardo, A. S., Gambino, M. L., Ballotari, P., Giacomazzi, E., Ferretti, S., Caldarella, A., Manneschi, G., Gatta, G., Baili, P., Berrino, F., Botta, L., Trama, A., Lillini, R., Bernasconi, A., Bonfarnuzzo, S., Didone, F., Lasalvia, P., Del Monego, G., Magri, M. C., Buratti, L., Serraino, D., Dal Maso, L., Capocaccia, R., Demuru, E., Di Benedetto, C., Santaquilani, M., Venanzi, S., Filiberti, R. A., Iacovacci, S., Gennaro, V., Russo, A. G., Spagnoli, G., D'Oro, L. C., Fusco, M., Vitale, M. F., Usala, M., Vitale, F., Michiara, M., Chiranda, G., Cascone, G., Spata, E., Mangone, L., Falcini, F., Cavallo, R., Piras, D., Madeddu, A., Bella, F., Fanetti, A. C., Minerba, S., Candela, G., Scuderi, T., Rizzello, R. V., Stracci, F., Tagliabue, G., Rugge, M., Brustolin, A., Pildava, S., Smailyte, G., Azzopardi, M., Johannesen, T. B., Didkowska, J., Wojciechowska, U., Bielska-Lasota, M., Pais, A., Pontes, J. L., Miranda, A., Diba, C. S., Zadnik, V., Zagar, T., Escudero, C. S. -C., Sureda, P. F., de Munain, A. L., De-La-cruz, M., Rojas, M. D., Aleman, A., Vizcaino, A., Sanchez, M. J., Chirlaque, M. D., Eslava, M. G., Ardanaz, E., Galceran, J., Carulla, M., Bergeron, Y., Bouchardy, C., Mousavi, S. M., Bordoni, A., Visser, O., Rashbass, J., Gavin, A., Morrison, D., and Huws, D. W.

Subjects
Cancer Research, Survival, real-world data, randomized controlled trials (RCTs), tyrosine kinase inhibitor (TKI), population-based studies, Tyrosine kinase inhibitor (TKI), Randomized controlled trials (RCTs), survival, Real-world data, Europe, Oncology, cancer registries, chronic myeloid leukemia (CML), Chronic myeloid leukemia (CML), Cancer registries, Population-based studies
Abstract

This study was funded by the Compagnia di San Paolo, the Cariplo Foundation and the European Commission (grant number 801520 HP-JA-2017, Innovative Partnership for Action Against Cancer, iPAAC Joint Action). The sources of the funding played no role in designing the study, collecting, analyzing, or interpreting the data, writing the report, or deciding whether or not to submit the article for publication. This research was (partially) funded by Italian Ministry of Health "Ricerca Corrente" funds. Tyrosine kinase inhibitors (TKIs) have been improving the prognosis of patients with chronic myeloid leukemia (CML), but there are still large differences in survival among European countries. This raises questions on the added value of results from population-based studies, which use real-world data, compared to results of randomized controlled trials (RCTs) involving patients with CML. There are also questions about the extent of the findings on RCTs effectiveness for patients in the general population. We compare survival data extracted from our previous systematic review and meta-analysis of CML RCTs with the latest updated population-based survival data of EUROCARE-6, the widest collaborative study on cancer survival in Europe. The EUROCARE-6 CML survival estimated in patients (15-64 years) diagnosed in 2000-2006 vs. 2007-2013 revealed that the prognostic improvement highlighted by RCTs was confirmed in real-world settings, too. The study shows, evaluating for the first time all European regions, that the optimal outcome figures obtained in controlled settings for CML are also achievable (and indeed achieved) in real-world settings with prompt introduction of TKIs in daily clinical practice. However, some differences still persist, particularly in Eastern European countries, where overall survival values are lower than elsewhere, probably due to a delayed introduction of TKIs. Our results suggest an insufficient adoption of adequate protocols in daily clinical practice in those countries where CML survival values remain lower in real life than the values obtained in RCTs. New high-resolution population-based studies may help to identify failures in the clinical pathways followed there.

Published
2022

36. Advancing the JUNGFRAU detector toward low-energy X-ray applications

Author

Hinger, V., primary, al Haddad, A., additional, Barten, R., additional, Bergamaschi, A., additional, Brückner, M., additional, Carulla, M., additional, Chiriotti-Alvarez, S., additional, Dinapoli, R., additional, Ebner, S., additional, Fröjdh, E., additional, Greiffenberg, D., additional, Hasanaj, S., additional, King, T., additional, Kozlowski, P., additional, Lopez-Cuenca, C., additional, Mezza, D., additional, Moustakas, K., additional, Mozzanica, A., additional, Ozerov, D., additional, Ruder, C., additional, Schmitt, B., additional, Schnorr, K.A., additional, Thattil, D., additional, and Zhang, J., additional

Published
2022
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37. Recommendations on compiling test datasets for evaluating artificial intelligence solutions in pathology

Author

Homeyer, A., Geißler, C., Ole Schwen, L., Zakrzewski, F., Evans, T., Strohmenger, K., Westphal, M., David Bülow, R., Kargl, M., Karjauv, A., Munné-Bertran, I., Orge Retzlaff, C., Romero-López, A., Sołtysiński, T., Plass, M., Carvalho, R., (0000-0002-4974-230X) Steinbach, P., Lan, Y.-C., Bouteldja, N., Haber, D., Rojas-Carulla, M., Vafaei Sadr, A., Kraft, M., Krüger, D., Fick, R., Lang, T., Boor, P., Müller, H., Hufnagl, P., Zerbe, N., Homeyer, A., Geißler, C., Ole Schwen, L., Zakrzewski, F., Evans, T., Strohmenger, K., Westphal, M., David Bülow, R., Kargl, M., Karjauv, A., Munné-Bertran, I., Orge Retzlaff, C., Romero-López, A., Sołtysiński, T., Plass, M., Carvalho, R., (0000-0002-4974-230X) Steinbach, P., Lan, Y.-C., Bouteldja, N., Haber, D., Rojas-Carulla, M., Vafaei Sadr, A., Kraft, M., Krüger, D., Fick, R., Lang, T., Boor, P., Müller, H., Hufnagl, P., and Zerbe, N.

Abstract

Artificial intelligence (AI) solutions that automatically extract information from digital histology images have shown great promise for improving pathological diagnosis. Prior to routine use, it is important to evaluate their predictive performance and obtain regulatory approval. This assessment requires appropriate test datasets. However, compiling such datasets is challenging and specific recommendations are missing. A committee of various stakeholders, including commercial AI developers, pathologists, and researchers, discussed key aspects and conducted extensive literature reviews on test datasets in pathology. Here, we summarize the results and derive general recommendations on compiling test datasets. We address several questions: Which and how many images are needed? How to deal with low-prevalence subsets? How can potential bias be detected? How should datasets be reported? What are the regulatory requirements in different countries? The recommendations are intended to help AI developers demonstrate the utility of their products and to help pathologists and regulatory agencies verify reported performance measures. Further research is needed to formulate criteria for sufficiently representative test datasets so that AI solutions can operate with less user intervention and better support diagnostic workflows in the future.

Published
2022

38. Registration of Urothelial Tumours in Cancer Registries: How to Improve and Make It More Useful?

Author

Medicina i Cirurgia, Universitat Rovira i Virgili, Daubisse-Marliac L; Grosclaude P; Carulla M; Parada D; Vilardell L; Ameijide A; Marcos-Gragera R; Galceran J, Medicina i Cirurgia, Universitat Rovira i Virgili, and Daubisse-Marliac L; Grosclaude P; Carulla M; Parada D; Vilardell L; Ameijide A; Marcos-Gragera R; Galceran J

Abstract

Due to the differences in the definition, criteria of inclusion and coding of urothelial tumours (UTs), data of different cancer registries (CRs) are not comparable. The aim of this work is to study current practices of registration of UT in the European CR of the GRELL countries in order to propose new registration rules to correctly describe incidence and survival of progressive tumours like UT. A questionnaire was sent to 91 CRs to assess whether non-invasive (NI)UT, multiple UTs, UTs occurring outside or before the operating period and time between UTs are currently considered in tumour recording and reporting. All participating CRs (n = 42) record a NI bladder UT in sole occurrence. In case of progressive bladder UT, 98% of the CRs record at least one NIUT but 19% don’t record the invasive progression. 17% of the CRs don’t record an invasive pelvic tumour that occurs after a NI bladder UT. 19% of the CRs don’t record an invasive bladder UT that followed a NI tumour occurring outside the zone or period of time. The recording of two synchronous UTs is carried out with a grouping topography for 36% of the CRs. The same analysis conducted on the reporting of the incidence of UT also shows heterogeneity. We conclude that there is an urgent need to define clear rules for the registration of UT.

Published
2022

39. Predicting Ovarian-Cancer Burden in Catalonia by 2030: An Age–Period–Cohort Modelling

Author

Universitat Rovira i Virgili, Peremiquel-Trillas P; Frias-Gomez J; Alemany L; Ameijide A; Vilardell M; Marcos-Gragera R; Paytubi S; Ponce J; Martínez JM; Pineda M; Brunet J; Matías-Guiu X; Carulla M; Galceran J; Izquierdo Á; Borràs JM; Costas L; Clèries R, Universitat Rovira i Virgili, and Peremiquel-Trillas P; Frias-Gomez J; Alemany L; Ameijide A; Vilardell M; Marcos-Gragera R; Paytubi S; Ponce J; Martínez JM; Pineda M; Brunet J; Matías-Guiu X; Carulla M; Galceran J; Izquierdo Á; Borràs JM; Costas L; Clèries R

Abstract

Ovarian cancer is the most lethal gynaecological cancer in very-high-human-developmentindex regions. Ovarian cancer incidence and mortality rates are estimated to globally rise by 2035, although incidence and mortality rates depend on the region and prevalence of the associated risk factors. The aim of this study is to assess changes in incidence and mortality of ovarian cancer in Catalonia by 2030. Bayesian autoregressive age–period–cohort models were used to predict the burden of OC incidence and mortality rates for the 2015–2030 period. Incidence and mortality rates of ovarian cancer are expected to decline in Catalonia by 2030 in women ≥ 45 years of age. A decrease in ovarian-cancer risk was observed with increasing year of birth, with a rebound in women born in the 1980s. A decrease in mortality was observed for the period of diagnosis and period of death. Nevertheless, ovarian-cancer mortality remains higher among older women compared to other age groups. Our study summarizes the most plausible scenario for ovarian-cancer changes in terms of incidence and mortality in Catalonia by 2030, which may be of interest from a public health perspective for policy implementation.

Published
2022

40. High-spatial resolution measurements with a GaAs:Cr sensor using the charge integrating MÖNCH detector with a pixel pitch of 25 μm

Author

Chiriotti, S., primary, Barten, R., additional, Bergamaschi, A., additional, Brückner, M., additional, Carulla, M., additional, Chsherbakov, I., additional, Dinapoli, R., additional, Fröjdh, E., additional, Greiffenberg, D., additional, Hasanaj, S., additional, Hinger, V., additional, King, T., additional, Kozlowski, P., additional, Lopez-Cuenca, C., additional, Lozinskaya, A., additional, Marone, F., additional, Mezza, D., additional, Moustakas, K., additional, Mozzanica, A., additional, Ruder, C., additional, Schmitt, B., additional, Thattil, D., additional, Tolbanov, O., additional, Tyazhev, A., additional, Zarubin, A., additional, and Zhang, J., additional

Published
2022
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41. Incidence of myeloid neoplasms in Spain (2002–2013): a population-based study of the Spanish network of cancer registries

Author

Solans, M., Sanvisens, A., Ameijide, Alberto, Merino, S., Rojas, Dolores, Alemán, A., Banqueri, E., Chico, Matilde, Marcos, A.I., de Castro, Visitación, Gil, L., López de Munain, Arantza, Puigdemont, Montse, Sánchez, M.J., Perucha, J., Ruiz-Armengol, P., Chirlaque, María-Dolores, Guevara, M., Carulla, M., Marcos-Gragera, Rafael, and Universitat Autònoma de Barcelona

Subjects
Adult, Male, Time Factors, Càncer -- Estadístiques, Epidemiology, Science, Leucèmia mieloide, Article, Myeloproliferative disease, Humans, Registries, Aged, Aged, 80 and over, Multidisciplinary, Myeloproliferative Disorders, Cancer -- Statistics, Incidence, Tumors -- Espanya, Middle Aged, Health Surveys, Leukemia, Myeloid, Acute, Tumors -- Spain, Myeloid leukemia, Spain, Myelodysplastic Syndromes, Medicine, Female, Myelodysplastic syndrome
Abstract

This work was partially funded by the Josep Carreras Leukaemia Research Institute (Grant No.: FIJC1100); the Ministry of Science, Innovation and Universities, Carlos III Health Institute (ISCIII), Spain (Grant No.: PI15/00966); the Agency for Management of University and Research Grants, Government of Catalonia (Grant No.: 2017SGR00733); the CIBER of Epidemiology and Public Health (CIBERESP) (`Cohort-Real World Data' subprogram)., Comprehensive population-based data on myeloid neoplasms (MNs) are limited, mainly because some subtypes were not recognized as hematological cancers prior to the WHO publication in 2001, and others are too rare to allow robust estimates within regional studies. Herein, we provide incidence data of the whole spectrum of MNs in Spain during 2002–2013 using harmonized data from 13 population-based cancer registries. Cases (n = 17,522) were grouped following the HAEMACARE groupings and 2013-European standardized incidence rates ( ASRE), incidence trends, and estimates for 2021 were calculated. ASRE per 100,000 inhabitants was 5.14 (95% CI: 5.00–5.27) for myeloproliferative neoplasms (MPN), 4.71 (95% CI: 4.59–4.84) for myelodysplastic syndromes (MDS), 3.91 (95% CI: 3.79–4.02) for acute myeloid leukemia, 0.83 (95% CI: 0.78–0.88) for MDS/MPN, 0.35 (95% CI: 0.32–0.39) for acute leukemia of ambiguous lineage, and 0.58 (95% CI: 0.53–0.62) for nototherwise specified (NOS) cases. This study highlights some useful points for public health authorities, such as the remarkable variability in incidence rates among Spanish provinces, the increasing incidence of MPN, MDS, and MDS/MPN during the period of study, in contrast to a drop in NOS cases, and the number of cases expected in 2021 based on these data (8446 new MNs)., Josep Carreras Leukaemia Research Institute FIJC1100, Ministry of Science, Innovation and Universities, Carlos III Health Institute (ISCIII), Spain PI15/00966, Agency for Management of University and Research Grants, Government of Catalonia 2017SGR00733, CIBER of Epidemiology and Public Health (CIBERESP) ('Cohort-Real World Data' subprogram)

Published
2022

44. Inverse Low Gain Avalanche Detectors (iLGADs) for precise tracking and timing applications

Author

Ministerio de Economía y Competitividad (España), Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), European Commission, Currás, Esteban, Carulla, M., Centis Vignali, M., Duarte Campderros, J., Fernández-García, Marcos, Flores, David, García Alonso, A., Gómez, Gervasio, González, Javier G., Hidalgo, Salvador, Jaramillo, R., Merlos Domingo, Ángel, Moll, Michael, Pellegrini, Giulio, Quirion, David, Vila, Iván, Ministerio de Economía y Competitividad (España), Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), European Commission, Currás, Esteban, Carulla, M., Centis Vignali, M., Duarte Campderros, J., Fernández-García, Marcos, Flores, David, García Alonso, A., Gómez, Gervasio, González, Javier G., Hidalgo, Salvador, Jaramillo, R., Merlos Domingo, Ángel, Moll, Michael, Pellegrini, Giulio, Quirion, David, and Vila, Iván

Abstract

Low Gain Avalanche Detector (LGAD) is the baseline sensing technology of the recently proposed Minimum Ionizing Particle (MIP) end-cap timing detectors (MTD) at the Atlas and CMS experiments. The current MTD sensor is designed as a multi-pad matrix detector delivering a poor position resolution, due to the relatively large pad area, around 1 mm2; and a good timing resolution, around 20–30 ps. Besides, in his current technological incarnation, the timing resolution of the MTD LGAD sensors is severely degraded once the MIP particle hits the inter-pad region since the signal amplification is missing for this region. This limitation is named as the LGAD fill-factor problem. To overcome the fill factor problem and the poor position resolution of the MTD LGAD sensors, a p-in-p LGAD (iLGAD) was introduced. Contrary to the conventional LGAD, the iLGAD has a non-segmented deep p-well (the multiplication layer). Therefore, iLGADs should ideally present a constant gain value over all the sensitive region of the device without gain drops between the signal collecting electrodes; in other words, iLGADs should have a 100% fill-factor by design. In this paper, tracking and timing performance of the first iLGAD prototypes is presented.

Published
2020

45. Excess mortality among breast cancer patients in early stages in Tarragona and Gerona (Spain) [Exceso de mortalidad en las pacientes con cáncer de mama en estadios precoces en Tarragona y Gerona (España)]

Author

Universitat Rovira i Virgili, Clèries R., Ameijide A., Buxó M., Vilardell M., Martínez J.M., Marcos-Gragera R., Vilardell M.L., Carulla M., Espinàs J.A., Galceran J., Borràs J.M., Izquierdo Á., Universitat Rovira i Virgili, and Clèries R., Ameijide A., Buxó M., Vilardell M., Martínez J.M., Marcos-Gragera R., Vilardell M.L., Carulla M., Espinàs J.A., Galceran J., Borràs J.M., Izquierdo Á.

Abstract

© 2018 SESPAS Objective: To analyze the population-based survival of breast cancer (CM) diagnosed in early stages estimating the time trends of excess mortality (EM) in the long term in annual and five-year time intervals, and to determine, if possible, a proportion of patients who can be considered cured. Method: We included women diagnosed with BC under the age of 60 years in stages I and II in Girona and Tarragona (N = 2453). The observed (OS) and relative survival (RS) were calculated up to 20 years of follow-up. RS was also estimated at annual (RSI) and in five-year intervals (RS5) to graphically assess the EM. The results are presented by age groups (≤49 and 50-59), stage (I/II) and diagnostic period (1985-1994 and 1995-2004). Results: In stage I, OS and RS were higher during 1995-2004 compared to 1985-1994: 3.5% at 15 years of follow-up and 4.5% at 20-years of follow-up. In 1995-2004, the OS surpassed 80% in stage I patients whereas in stage II it remained below 70%. During 1995-2004, the long-term EM did not level off towards 0 (RSI <1) independently of age group, stage and period of diagnosis. After 15 years of follow-up, the 5-year EM oscillated between 1 and 5% in stage I (RS5 ≥0.95) and between 5 and 10% in stage II. Conclusions: In our cohort, after 15 years of follow-up, it was detected that the annual EM did not disappear and the five-year EM remained between 1 and 10%. Therefore, it was not possible to determine a cure rate of BC during the study period.

Published
2020

46. Population-based risk assessment of second primary cancers following a first head and neck cancer: patterns of association and difficulties of its analysis

Author

Rubió-Casadevall, J., primary, Galceran, J., additional, Ameijide, A., additional, Puigdemont, M., additional, Llauradó, L., additional, Marruecos, J., additional, Izquierdo, A., additional, Carulla, M., additional, Borràs, J. L., additional, Marcos-Gragera, R., additional, and Gumà, J., additional

Published
2020
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49. Reasons for low cervical cancer survival in new accession European Union countries: a EUROCARE-5 study

Author

Bielska-Lasota, M., Rossi, S., Krzyzak, M., Haelens, A., Domenic, A., De Angelis, R., Maciejczyk, A., Rodriguez-Barranco, M., Zadnik, V., Minicozzi, P., Hackl, M., Ihle, P., Vaneycken, E., Henau, K., Valerianova, Z., Dimitrova, N., Sekerija, M., Cukelj, P., Dusek, L., Zvolsky, M., Magi, M., Aareleid, T., Malila, N., Seppa, K., Velten, M., Guizard, A. V., Faivre, J., Woronoff, A. S., Tretarre, B., Bossard, N., Uhry, Z., Colonna, M., Molinie, F., Cowppli-Bony, A., Bara, S., Lapotre-Ledoux, B., Grosclaude, P., Stabenow, R., Luttmann, S., Eberle, A., Brenner, H., Nennecke, A., Engel, J., Schubert-Fritschle, G., Heidrich, J., Holleczek, B., Katalinic, A., Birgisson, H., Tryggvadottir, L., Clough-Gorr, K., Mazzoleni, G., Bulatko, A., Buzzoni, C., Suterasardo, A., Mancuso, P., Ferretti, S., Barchielli, A., Caldarella, A., Gatta, G., Sant, M., Amati, C., Baili, P., Berrino, F., Bonfarnuzzo, S., Botta, L., Capocaccia, R., Foschi, R., Margutti, C., Meneghini, E., Trama, A., Serraino, D., Dalmaso, L., Deangelis, R., Dibenedetto, C., Caldora, M., Francisci, S., Galati, F., Mallone, S., Pierannunzio, D., Tallon, M., Santaquilani, M., Tavilla, A., Pannozzo, F., Busco, S., Filiberti, R. A., Marani, E., Ricci, P., Spagnoli, G., Cirilli, C., Fusco, M., Vitale, M. F., Usala, M., Vitale, F., Mazzucco, W., Michiara, M., Zanetti, R., Rosso, S., Tumino, R., Mangone, L., Difelice, E., Russo, A. G., Andreano, A., Falcini, F., Caiazzo, A. L., Cesaraccio, R., Piffer, S., Madeddu, A., Tisano, F., Fanetti, A. C., Cometti, I., Candela, P., Scuderi, T., Stracci, F., Bianconi, F., Tagliabue, G., Contiero, P., Rugge, M., Zorzi, M., Pildava, S., Smailyte, G., Azzopardi, M., Calleja, N., Johannesen, T. B., Rachtan, J., Gozdz, S., Macek, P., Blaszczyk, J., Bebenek, M., Forjaz deLacerda, G., Bento, M. J., Antunes, L., Miranda, A., Mayer-da-Silva, A., Safaeidiba, C., Primic-Zakelj, M., Lopez deMunain, A., Gil, L., Diazgarcia, J. M., Marcos-Navarro, A. I., Marcos-Gragera, R., Puigdemont, M., Sanchez, M. J., Chang, D. Y. L., Chirlaque, M. D., Ardanaz, E., Guevara, M., Galceran, J., Carulla, M., Lambe, M., Khan, S., Staehelin, K., Bouchardy, C., Fournier, E., Mousavi, S. M., Ess, S. M., Lorez, M., Mousavi, M., Herrmann, C., Bordoni, A., Spitale, A., Konzelmann, I., Visser, O., Aarts, M., Otter, R., Coleman, M., Allemani, C., Rachet, B., Rashbass, J., Broggio, J., Verne, J., Gavin, A., Donnelly, D., Morrison, D., Black, R., Huws, D. W., Thomas, R., Bielska‑Lasota, M, Rossi, S, Krzyżak, M, Haelens, A, Domenic, A, De Angelis, R, Maciejczyk, A, Rodríguez‑Barranco, M, Zadnik, V, Minicozzi, P, Vitale, F, and Mazzucco, W

Subjects
Morphology, Adult, Male, Stage at diagnosi, Survival, Adolescent, Socio-culturale, Uterine Cervical Neoplasms, Disease, Settore MED/42 - Igiene Generale E Applicata, 03 medical and health sciences, 0302 clinical medicine, Medicine, media_common.cataloged_instance, Humans, European Union, European union, Survival rate, Population-based study, media_common, Aged, Retrospective Studies, Cervical cancer, Aged, 80 and over, Cervical cancer, Europe, Morphology, Population-based study, Stage at diagnosis, Survival, 030219 obstetrics & reproductive medicine, Relative survival, business.industry, Absolute risk reduction, Obstetrics and Gynecology, Retrospective cohort study, Stage at diagnosis, General Medicine, Middle Aged, medicine.disease, Europe, Eastern european, Survival Rate, 030220 oncology & carcinogenesis, Female, business, Demography
Abstract

Purpose: With better access to early diagnosis and appropriate treatment, cervical cancer (CC) burden decreased in several European countries. In Eastern European (EE) countries, which accessed European Union in 2004, CC survival was worse than in the rest of Europe. The present study investigates CC survival differences across five European regions, considering stage at diagnosis (local, regional and metastatic), morphology (mainly squamous versus glandular tumours) and patients’ age. Methods: We analysed 101,714 CC women diagnosed in 2000–2007 and followed-up to December 2008. Age-standardised 5-year relative survival (RS) and the excess risks of cancer death in the 5years after diagnosis were computed. Results: EE women were older and less commonly diagnosed with glandular tumours. Proportions of local stage cancers were similar across Europe, while morphology- and stage-specific RS (especially for non-metastatic disease) were lower in Eastern Europe. Adjusting for age and morphology, excess risk of local stage CC death for EE patients remained higher than that for other European women. Conclusion: Stage, age and morphology alone do not explain worse survival in Eastern Europe: less effective care may play a role, probably partly due to fewer or inadequate resources being allocated to health care in this area, compared to the rest of Europe.

Published
2019

50. Epidemiology of congenital Chagas disease 6 years after implementation of a public health surveillance system, Catalonia, 2010 to 2015

Author

Martin-Nalda, A, Cebollero, A, Carrascon, A, Moreira, A, Requena-Mendez, A, Soto, AT, Martin, A, Ballester, A, Bragulat, A, Soligo, A, Bastarras, AV, Paya, A, Soriano-Arandes, A, Sorni, A, Calvo, A, Mur, A, Colomer, A, Carral, B, Trevino, B, Guarch, B, Orta, C, Rodrigo, C, Galles, C, Garrido, C, Molina, C, Mora, C, Munoz, C, Marti, C, Sanjose, C, Guardia, C, Cortes, C, Gutierrez, C, Martinez, C, Riera, C, Soler, C, Gonzalez, D, Guix, D, Mir, ES, Padilla, E, Sulleiro, E, Llurba, E, Del Amo, E, Moliner, E, Esteba, EP, Coll, E, Rodriguez, E, Monaco, E, Munoz, E, Freixas, E, Dopico, E, Sarda, E, Ballester, F, Gomez, F, Barranco, F, Ripoll, F, Fargas, FJ, Falguera, G, Fernandez-Rivas, G, Ginovart, G, Navarro, G, Garcia-Pardo, G, Lorenzo, G, Ouaarab, H, Caubet, I, Claveria, I, Sanfeliu, I, Molina, I, Blanch, J, Marti, JA, Farre, J, Gascon, J, Costa, J, Prat, JGI, Fulquet, J, Jove, JP, Armengol, J, Riera, JC, Villar, J, Torrent, LS, De La Torre, L, Delgado, L, Valerio, L, Montsant, L, Basile, L, Mayol, L, Valls, ME, Vives, MA, Sauca, MG, Coll, M, Pinazo, MJ, Ferri, MJ, Vidal, MJ, Villegas, ML, Anquela, MAS, Monsonis, M, Blasco, MP, Perez-Moreno, MO, Sabates, MC, Mendez, M, Navarro, M, Urcola, M, Lora, M, Almirall, M, Arasa, M, Alaball, MV, Carulla, M, Jane, M, Ribell-Bachs, M, Abella, M, Gallego, M, Prat, N, Rius, N, Bosh, NP, Garcia, P, Araujo, P, Sole, P, Ciruela, P, Villalobos, P, Almirall, R, Diaz, R, Puigarnau, R, Serra, R, Diez, R, Bosch, ST, Franch, S, Vega, S, Mani, SG, Juncosa, T, Pineda, V, Fumado, V, and Urquizu, X

Abstract

Background: Chagas disease is endemic in Latin America and affects 8 million people worldwide. In 2010, Catalonia introduced systematic public health surveillance to detect and treat congenital Chagas disease. Aim: The objective was to evaluate the health outcomes of the congenital Chagas disease screening programme during the first 6 years (2010-2015) after its introduction in Catalonia. Methods: In a surveillance system, we screened pregnant women and newborns and other children of positive mothers, and treated Chagas-positive newborns and children. Diagnosis was confirmed for pregnant women and children with two positive serological tests and for newborns with microhaematocrit and/or PCR at birth or serology at age 9 months. Results: From 2010 to 2015, the estimated screening coverage rate increased from 68.4% to 88.6%. In this period, 33,469 pregnant women were tested for Trypanosoma cruzi and 937 positive cases were diagnosed. The overall prevalence was 2.8 cases per loo pregnancies per year (15.8 in Bolivian women). We followed 82.8% of newborns until serological testing at age 9-12 months and 28 were diagnosed with Chagas disease (congenital transmission rate: 4.17%). Of 518 siblings, 178 (34.3%) were tested and 14 (7.8%) were positive for T. cruzi. Having other children with Chagas disease and the heart clinical form of Chagas disease were maternal risk factors associated with congenital T. cruzi infection (p < 0.05). Conclusion: The increased screening coverage rate indicates consolidation of the programme in Catalonia. The rate of Chagas disease congenital transmission in Catalonia is in accordance with the range in non-endemic countries.

Published
2019

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