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6. Potential outcome approach to causal inference in assessing the short term impact of air pollution on mortality

Author

Baccini, Michela, Mattei, Alessandra, Mealli, Fabrizia, Bertazzi, Pier Alberto, and Carugno, Michele

Subjects
Statistics - Applications, Statistics - Methodology
Abstract

The opportunity to assess short term impact of air pollution relies on the causal interpretation of the exposure-outcome association, but up to now few studies explicitly faced this issue within a causal inference framework. In this paper, we reformulated the problem of assessing the short term impact of air pollution on health using the potential outcome approach to causal inference. We focused on the impact of high daily levels of PM10 on mortality within two days from the exposure in the metropolitan area of Milan (Italy), during the period 2003-2006. After defining the number of attributable deaths in terms of difference between potential outcomes, we used the estimated propensity score to match each high exposure-day with a day with similar background characteristics but lower PM10 level. Then, we estimated the impact by comparing mortality between matched days. We found that during the study period daily exposures larger than 40 microgram per cubic meter were responsible of 1079 deaths (116; 2042). The impact was more evident among the elderly than in the younger classes of age. The propensity score matching turned out to be an appealing method to assess historical impacts in this field.

Published
2016

7. Time-Trends in Air Pollution Impact on Health in Italy, 1990-2019: An Analysis From the Global Burden of Disease Study 2019.

Author

Conti, Sara, Fornari, Carla, Ferrara, Pietro, Antonazzo, Ippazio C., Madotto, Fabiana, Traini, Eugenio, Levi, Miriam, Cernigliaro, Achille, Armocida, Benedetta, Bragazzi, Nicola L., Cadum, Ennio, Carugno, Michele, Crotti, Giacomo, Deandrea, Silvia, Cortesi, Paolo A., Guido, Davide, Iavicoli, Ivo, Iavicoli, Sergio, La Vecchia, Carlo, and Lauriola, Paolo

Subjects
GLOBAL burden of disease, AIR pollution, PARTICULATE matter, EPISTEMIC uncertainty, AIR quality
Abstract

Objectives: We explored temporal variations In disease burden of ambient particulate matter 2.5 pm or less in diameter (PM2.5) and ozone in Italy using estimates from the Global Burden of Disease Study 2019. Methods: We compared temporal changes and percent variations (95% Uncertainty Intervals [95% UI]) in rates of disability adjusted life years (DALYs), years of life lost, years lived with disability and mortality from 1990 to 2019, and variations in pollutant-attributable burden with those in the overall burden of each PM2.5- and ozone-related disease. Results: In 2019, 467,000 DALYs (95% UI: 371,000, 570,000) were attributable to PM2.5 and 39,600 (95% UI: 18,300, 61,500) to ozone. The crude DALY rate attributable to PM2.5 decreased by 47.9% (95% UI: 10.3, 65.4) from 1990 to 2019. For ozone, it declined by 37.0% (95% UI: 28.9, 44.5) during 1990-2010, but it increased by 44.8% (95% UI: 35.5, 56.3) during 2010-2019. Age-standardized rates declined more than crude ones. Conclusion: In Italy, the burden of ambient PM2.5 (but not of ozone) significantly decreased, even in concurrence with population ageing. Results suggest a positive impact of air quality regulations, fostering further regulatory efforts. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Time-Trends in Air Pollution Impact on Health in Italy, 1990–2019: An Analysis From the Global Burden of Disease Study 2019

Author

Conti, Sara, primary, Fornari, Carla, additional, Ferrara, Pietro, additional, Antonazzo, Ippazio C., additional, Madotto, Fabiana, additional, Traini, Eugenio, additional, Levi, Miriam, additional, Cernigliaro, Achille, additional, Armocida, Benedetta, additional, Bragazzi, Nicola L., additional, Cadum, Ennio, additional, Carugno, Michele, additional, Crotti, Giacomo, additional, Deandrea, Silvia, additional, Cortesi, Paolo A., additional, Guido, Davide, additional, Iavicoli, Ivo, additional, Iavicoli, Sergio, additional, La Vecchia, Carlo, additional, Lauriola, Paolo, additional, Michelozzi, Paola, additional, Scondotto, Salvatore, additional, Stafoggia, Massimo, additional, Violante, Francesco S., additional, Abbafati, Cristiana, additional, Albano, Luciana, additional, Barone-Adesi, Francesco, additional, Biondi, Antonio, additional, Bosetti, Cristina, additional, Buonsenso, Danilo, additional, Carreras, Giulia, additional, Castelpietra, Giulio, additional, Catapano, Alberico, additional, Cattaruzza, Maria S., additional, Corso, Barbara, additional, Damiani, Giovanni, additional, Esposito, Francesco, additional, Gallus, Silvano, additional, Golinelli, Davide, additional, Hay, Simon I., additional, Isola, Gaetano, additional, Ledda, Caterina, additional, Mondello, Stefania, additional, Pedersini, Paolo, additional, Pensato, Umberto, additional, Perico, Norberto, additional, Remuzzi, Giuseppe, additional, Sanmarchi, Francesco, additional, Santoro, Rocco, additional, Simonetti, Biagio, additional, Unim, Brigid, additional, Vacante, Marco, additional, Veroux, Massimiliano, additional, Villafañe, Jorge H., additional, Monasta, Lorenzo, additional, and Mantovani, Lorenzo G., additional

Published
2023
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11. Air Pollution and Perinatal Mental Health: A Comprehensive Overview

Author

Surace, Teresa, primary, Quitadamo, Cecilia, additional, Caldiroli, Alice, additional, Capuzzi, Enrico, additional, Colmegna, Fabrizia, additional, Nosari, Guido, additional, Borroni, Elisa, additional, Fedrizzi, Luca, additional, Bollati, Valentina, additional, Pesatori, Angela Cecilia, additional, Carugno, Michele, additional, Clerici, Massimo, additional, and Buoli, Massimiliano, additional

Published
2023
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20. PM 2.5,PM 10and bronchiolitis severity: A cohort study

Author

Milani, Gregorio P., primary, Cafora, Marco, additional, Favero, Chiara, additional, Luganini, Anna, additional, Carugno, Michele, additional, Lenzi, Erica, additional, Pistocchi, Anna, additional, Pinatel, Eva, additional, Pariota, Luigi, additional, Ferrari, Luca, additional, and Bollati, Valentina, additional

Published
2022
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21. Side effects among healthcare workers from a large Milan university hospital after second dose of BNT162b2 mRNA COVID-19 vaccine

Author

Borroni, Elisa, Consonni, Dario, Cugno, Massimo, Lombardi, Andrea, Mangioni, Davide, Bono, Patrizia, Oggioni, Massimo, Uceda Renteria, Sara, Bordini, Lorenzo, Nava, Carlo Domenico, Letzgus, Matteo, Gentiloni Silverj, Flaminia, Castaldi, Silvana, Rognoni, Magda, Cavalieri D’Oro, Luca, Carugno, Michele, Riboldi, Luciano, Ceriotti, Ferruccio, Bandera, Alessandra, Gori, Andrea, and Pesatori, Angela Cecilia

Subjects
Adult, COVID-19 Vaccines, healthcare workers, SARS-CoV-2, Health Personnel, COVID-19, Original Articles, adverse events, Hospitals, COVID-19 Vaccination, Humans, Female, RNA, Messenger, BNT162 Vaccine
Abstract

Background: In Italy, healthcare workers (HCWs) were among the first to receive COVID-19 vaccination. Aim of the present study is to evaluate frequency and severity of adverse events (AEs) following the second dose of BNT162b2 vaccine among HCWs of a large university hospital in Milan, Italy. Methods: One month after having received the second dose of vaccine, HCWs filled-in a form about type, severity, and duration of post-vaccination local and systemic symptoms. We calculated the overall frequency of AEs and used multivariable Poisson regression models (adjusted for sex, age, BMI, smoking, allergy history, previous SARS-CoV-2 infection, anti-hypertensive therapy, and occupation) to calculate risk ratios (RR) and 95% confidence intervals (CI) of AEs according to selected variables. Results: We included 3659 HCWs. Overall, 2801 (76.6%) experienced at least one local event, with pain at injection site being the most frequent (2788, 76.2%). Systemic events were reported by 2080 (56.8%) HCWs, with fatigue (52.3%), muscle pain (42.2%), headache (37.7%), joint pain (31.9%), and fever (26.2%) being the most frequent. Risks of systemic events were associated with female gender (RR=1.14, CI: 1.06-1.24), age (strong decrease with increasing age, p-trend

Published
2021

25. Patterns of multisite pain and associations with risk factors

Author

Coggon, David, Ntani, Georgia, Palmer, Keith T., Felli, Vanda E., Harari, Raul, Barrero, Lope H., Felknor, Sarah A., Gimeno, David, Cattrell, Anna, Vargas-Prada, Sergio, Bonzini, Matteo, Solidaki, Eleni, Merisalu, Eda, Habib, Rima R., Sadeghian, Farideh, Masood Kadir, M., Warnakulasuriya, Sudath S.P., Matsudaira, Ko, Nyantumbu, Busisiwe, Sim, Malcolm R., Harcombe, Helen, Cox, Ken, Marziale, Maria H., Sarquis, Leila M., Harari, Florencia, Freire, Rocio, Harari, Natalia, Monroy, Magda V., Quintana, Leonardo A., Rojas, Marianela, Salazar Vega, Eduardo J., Harris, E. Clare, Serra, Consol, Martinez, J. Miguel, Delclos, George, Benavides, Fernando G., Carugno, Michele, Ferrario, Marco M., Pesatori, Angela C., Chatzi, Leda, Bitsios, Panos, Kogevinas, Manolis, Oha, Kristel, Sirk, Tuuli, Sadeghian, Ali, Peiris-John, Roshini J., Sathiakumar, Nalini, Wickremasinghe, A. Rajitha, Yoshimura, Noriko, Kelsall, Helen L., Hoe, Victor C.W, Urquhart, Donna M., Derrett, Sarah, McBride, David, Herbison, Peter, and Gray, Andrew

Published
2013
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26. Disabling musculoskeletal pain in working populations: Is it the job, the person, or the culture?

Author

Coggon, David, Ntani, Georgia, Palmer, Keith T., Felli, Vanda E., Harari, Raul, Barrero, Lope H., Felknor, Sarah A., Gimeno, David, Cattrell, Anna, Serra, Consol, Bonzini, Matteo, Solidaki, Eleni, Merisalu, Eda, Habib, Rima R., Sadeghian, Farideh, Masood Kadir, M., Warnakulasuriya, Sudath S.P., Matsudaira, Ko, Nyantumbu, Busisiwe, Sim, Malcolm R., Harcombe, Helen, Cox, Ken, Marziale, Maria H., Sarquis, Leila M., Harari, Florencia, Freire, Rocio, Harari, Natalia, Monroy, Magda V., Quintana, Leonardo A., Rojas, Marianela, Salazar Vega, Eduardo J., Harris, E. Clare, Vargas-Prada, Sergio, Martinez, J. Miguel, Delclos, George, Benavides, Fernando G., Carugno, Michele, Ferrario, Marco M., Pesatori, Angela C., Chatzi, Leda, Bitsios, Panos, Kogevinas, Manolis, Oha, Kristel, Sirk, Tuuli, Sadeghian, Ali, Peiris-John, Roshini J., Sathiakumar, Nalini, Wickremasinghe, A. Rajitha, Yoshimura, Noriko, Kelsall, Helen L., Hoe, Victor C.W., Urquhart, Donna M., Derrett, Sarah, McBride, David, Herbison, Peter, and Gray, Andrew

Published
2013
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31. Effectiveness of BNT162b2 COVID-19 vaccine among healthcare workers of a large hospital, Milan, Italy

Author

Consonni, Dario, primary, Lombardi, Andrea, additional, Mangioni, Davide, additional, Bono, Patrizia, additional, Oggioni, Massimo, additional, Renteria, Sara Uceda, additional, Bordini, Lorenzo, additional, Nava, Carlo Domenico, additional, Letzgus, Matteo, additional, Silverj, Flaminia Gentiloni, additional, Castaldi, Silvana, additional, Rognoni, Magda, additional, D'Oro, Luca Cavalieri, additional, Carugno, Michele, additional, Pesatori, Angela Cecilia, additional, Riboldi, Luciano, additional, Ceriotti, Ferruccio, additional, Bandera, Alessandra, additional, and Gori, Andrea, additional

Published
2022
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32. List of Contributors

Author

Álvarez-Errico, Damiana, primary, Bainor, Anthony J., additional, Ballestar, Esteban, additional, Bayón, Gustavo F., additional, Beekman, Renée, additional, Bibikova, Marina, additional, Bollati, Valentina, additional, Carugno, Michele, additional, Christensen, Brock C., additional, David, Gregory, additional, Fernández, Agustín F., additional, Figueroa, Maria E., additional, Fraga, Mario F., additional, Heyn, Holger, additional, Iodice, Simona, additional, Johnson, Kevin C., additional, Kulis, Marta, additional, Léveillé, Nicolas, additional, Ling, Charlotte, additional, Martín-Subero, José Ignacio, additional, McDevitt, Michael A., additional, Melo, Carlos A., additional, Melo, Sonia A., additional, Motta, Valeria, additional, Park, Yongseok, additional, Qin, Tingting, additional, Rönn, Tina, additional, Sartor, Maureen A., additional, and Woodhoo, Ashwin, additional

Published
2016
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36. P-195 Effectiveness of COVID-19 vaccine in health care workers, Milan, Italy

Author

Consonni, Dario, primary, Bono, Patrizia, additional, Oggioni, Massimo, additional, Renteria, Sara Uceda, additional, Piatti, Alessandra, additional, Castaldi, Silvana, additional, Muscatello, Antonio, additional, Carugno, Michele, additional, Riboldi, Luciano, additional, Ceriotti, Ferruccio, additional, Bandera, Alessandra, additional, Gori, Andrea, additional, Pesatori, Angela Cecilia, additional, and Lombardi, Andrea, additional

Published
2021
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38. PM2.5,PM10 and bronchiolitis severity: A cohort study.

Author

Milani, Gregorio P., Cafora, Marco, Favero, Chiara, Luganini, Anna, Carugno, Michele, Lenzi, Erica, Pistocchi, Anna, Pinatel, Eva, Pariota, Luigi, Ferrari, Luca, and Bollati, Valentina

Subjects
BRONCHIOLITIS, COHORT analysis, RESPIRATORY syncytial virus, PEDIATRIC emergency services, PARTICULATE matter
Abstract

Background: A few studies suggest that particulate matter (PM) exposure might play a role in bronchiolitis. However, available data are mostly focused on the risk of hospitalization and come from retrospective studies that provided conflicting results. This prospective study investigated the association between PM (PM2.5 and PM10) exposure and the severity of bronchiolitis. Methods: This prospective cohort study was conducted between November 2019 and February 2020 at the pediatric emergency department of the Fondazione IRCCS Ca′ Ospedale Maggiore Policlinico, Milan, Italy. Infants <1 year of age with bronchiolitis were eligible. The bronchiolitis severity score was assessed in each infant and a nasal swab was collected to detect respiratory viruses. The daily PM10 and PM2.5 exposure in the 29 preceding days were considered. Adjusted regression models were employed to evaluate the association between the severity score and PM10 and PM2.5 exposure. Results: A positive association between the PM2.5 levels and the severity score was found at day‐2 (β 0.0214, 95% CI 0.0011–0.0417, p =.0386), day‐5 (β 0.0313, 95% CI 0.0054–0.0572, p =.0179), day‐14 (β 0.0284, 95% CI 0.0078–0.0490, p =.0069), day‐15 (β 0.0496, 95% CI 0.0242–0.0750, p =.0001) and day‐16 (β 0.0327, 95% CI 0.0080–0.0574, p =.0093).Similar figures were observed considering the PM10 exposure and limiting the analyses to infants with respiratory syncytial virus. Conclusion: This study shows for the first time a direct association between PM2.5 and PM10 levels and the severity of bronchiolitis. [ABSTRACT FROM AUTHOR]

Published
2022
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45. SARS-CoV-2 infection among asymptomatic homebound subjects in Milan, Italy

Author

Milani, Gregorio Paolo, Montomoli, Emanuele, Bollati, Valentina, Albetti, Benedetta, Bandi, Claudio, Bellini, Tommaso, Bonzini, Matteo, Buscaglia, Marco, Cantarella, Carlo, Cantone, Laura, Carugno, Michele, Casartelli, Sergio, Cavaletti, Guido, D'Alessandro, Sarah, De Chiara, Francesca, Delbue, Serena, Dioni, Laura, Eberini, Ivano, Favero, Chiara, Ferrari, Luca, Ferraroni, Monica, Galastri, Laura, Galli, Cristina, Hoxha, Mirjam, Iodice, Simona, La Vecchia, Carlo, Macchi, Chiara, Manini, Ilaria, Marchi, Serena, Mariani, Jacopo, Pariani, Elena, Pesatori, Angela Cecilia, Rota, Federica, Ruscica, Massimiliano, Schioppo, Tommaso, Tarantini, Letizia, Trombetta, Claudia Maria, Valsecchi, Maria Grazia, Vicenzi, Marco, and Zanchetta, Giuliano

Published
2020
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46. Seroprevalence of anti-SARS-CoV-2 IgG among healthcare workers of a large university hospital in Milan, Lombardy, Italy: a cross-sectional study

Author

Lombardi, Andrea, primary, Mangioni, Davide, additional, Consonni, Dario, additional, Cariani, Lisa, additional, Bono, Patrizia, additional, Cantù, Anna Paola, additional, Tiso, Basilio, additional, Carugno, Michele, additional, Muscatello, Antonio, additional, Lunghi, Giovanna, additional, Pesatori, Angela Cecilia, additional, Riboldi, Luciano, additional, Ceriotti, Ferruccio, additional, Bandera, Alessandra, additional, and Gori, Andrea, additional

Published
2021
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47. Effects of aircraft noise on annoyance, sleep disorders, and blood pressure among adult residents near the Orio al Serio International Airport (BGY), Italy

Author

Carugno, Michele, Imbrogno, Piero, Zucchi, Alberto, Ciampichini, Roberta, Tereanu, Carmen, Sampietro, Giuseppe, Barbaglio, Giorgio, Pesenti, Bruno, Barretta, Francesco, Bertazzi, Pier Alberto, Pesatori, Angela C., and Consonni, Dario

Subjects
annoyance, Male, Sleep Wake Disorders, Aircraft, Airports, blood pressure, Middle Aged, Aircraft noise, Cross-Sectional Studies, Italy, Noise, Transportation, Hypertension, Humans, Original Article, sleep disorders, Female, human activities, Aged
Abstract

Background: Aircraft noise may cause several non-auditory health effects, including annoyance, sleep disorders, hypertension, cardiovascular diseases, and impaired cognitive skills in children. Objectives: To perform a cross-sectional study among adult residents near the Orio al Serio International Airport (BGY), Italy to investigate the association between aircraft noise, annoyance, sleep disorders, blood pressure levels, and prevalence of hypertension. Methods: Residential addresses of subjects aged 45-70 years were geocoded and classified in three groups according to noise levels

Published
2018

48. International variation in absence from work attributed to musculoskeletal illness: findings from the CUPID study

Author

Coggon, David, Ntani, Georgia, Vargas-Prada, Sergio, Martinez, José Miguel, Serra, Consol, Benavides, Fernando G, Palmer, Keith T, Felli, Vanda E, Harari, Raul, Barrero, Lope H, Felknor, Sarah A., Gimeno, David, Cattrell, Anna, Bonzini, Matteo, Solidaki, Eleni, Merisalu, Eda, Habib, Rima R., Sadeghian, Farideh, Kadir, M Masood, Warnakulasuriya, Sudath SP, Matsudaira, Ko, Nyantumbu, Busisiwe, Sim, Malcolm R, Harcombe, Helen, Cox, Ken, Marziale, Maria H, Sarquis, Leila M, Harari, Florencia, Freire, Rocio, Harari, Natalia, Monroy, Magda V, Quintana, Leonardo A, Rojas, Marianela, Vega, Eduardo J. Salazar, Harris, E Clare, Delclos, George, Carugno, Michele, Ferrario, Marco M, Pesatori, Angela C, Chatzi, Leda, Bitsios, Panos, Kogevinas, Manolis, Oha, Kristel, Sirk, Tuuli, Sadeghian, Ali, Peiris-John, Roshini J, Sathiakumar, Nalini, Wickremasinghe, A Rajitha, Yoshimura, Noriko, Kelsall, Helen L, Hoe, Victor C W, Urquhart, Donna M, Derrett, Sarah, McBride, David, Herbison, Peter, and Gray, Andrew

Published
2013
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50. Characteristics of 1,573 healthcare workers who underwent nasopharyngeal swab for SARS-CoV-2 in Milano, Lombardy, Italy

Author

Lombardi, Andrea, primary, Consonni, Dario, additional, Carugno, Michele, additional, Bozzi, Giorgio, additional, Mangioni, Davide, additional, Muscatello, Antonio, additional, Castelli, Valeria, additional, Palomba, Emanuele, additional, Cantù, Anna Paola, additional, Ceriotti, Ferruccio, additional, Tiso, Basilio, additional, Pesatori, Angela Cecilia, additional, Riboldi, Luciano, additional, Bandera, Alessandra, additional, and Gori, Andrea, additional

Published
2020
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