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12. Ruolo dei probiotici nella fibrosi epatica sperimentalmente indotta

Author

Cariello R., Tuccillo C., Mazzone G., Ribecco M. T., Amoruso D. C., Cartenì M., DE MAGISTRIS, Laura, D’Argenio G., LOGUERCIO, Carmelina, FEDERICO, Alessandro, Cariello, R., Tuccillo, C., Mazzone, G., Ribecco, M. T., Amoruso, D. C., Federico, Alessandro, Cartenì, M., DE MAGISTRIS, Laura, D’Argenio, G., and Loguercio, Carmelina

Published
2010

13. A probiotic treatment ameliorates CCl4-induced liver fibrosis in rats

Author

Cariello R., Tuccillo C., Mazzone G., Ribecco M., Amoruso D., Cartenì M., DE MAGISTRIS, Laura, D’Argenio G., LOGUERCIO, Carmelina, FEDERICO, Alessandro, Cariello, R., Tuccillo, C., Mazzone, G., Ribecco, M., Amoruso, D., Federico, Alessandro, Cartenì, M., DE MAGISTRIS, Laura, D’Argenio, G., and Loguercio, Carmelina

Published
2010

14. Intestinal permeability in patients with chronic liver diseases: It's relationship with the aetiology and the entity of liver damage

Author

CARIELLO R, SAPONE A, TUCCILLO C, SCIALDONE V. R, TISO A, MIRANDA A, PORTINCASA P, CARBONARA V, PALASCIANO G, MARTORELLI L, ESPOSITO P, CARTENÌ M, DEL VECCHIO BLANCO C, LOGUERCIO C. Cariello R, Federico A. equally contributed to this manuscript, FEDERICO, Alessandro, Cariello, R, Federico, Alessandro, Sapone, A, Tuccillo, C, Scialdone, V. R., Tiso, A, Miranda, A, Portincasa, P, Carbonara, V, Palasciano, G, Martorelli, L, Esposito, P, Cartenì, M, DEL VECCHIO BLANCO, C, LOGUERCIO C., Cariello R, and Federico A., equally contributed to this manuscript

Published
2010

15. Effetti metabolici della silibina: studi in vitro e in vivo

Author

STIUSO, Paola, Scognamiglio I., Murolo M., Biscaglia E., Tuccillo C., Del Prete A., Cartenì M., LOGUERCIO, Carmelina, FEDERICO, Alessandro, Stiuso, Paola, Scognamiglio, I., Murolo, M., Biscaglia, E., Federico, Alessandro, Tuccillo, C., Del Prete, A., Cartenì, M., and Loguercio, Carmelina

Published
2010

20. ROLE OF TLR PATHWAY IN THE PATHOGENESIS OF GLUTEN SENSITIVITY: PRELIMINARY STUDY

Author

Sapone A, Imbrici L, Giuliano MT, Cammarota M, De Rosa M, Cartenì M, Cariello R, Caravelli G, Martorelli L, TOLONE, Carlo, Familiari V, RIEGLER, Gabriele, Fasano A, DE MAGISTRIS, Laura, PAPPARELLA, Alfonso, Sapone, A, Imbrici, L, Giuliano, Mt, Cammarota, M, De Rosa, M, Cartenì, M, Cariello, R, Caravelli, G, Martorelli, L, Tolone, Carlo, Papparella, Alfonso, Familiari, V, Riegler, Gabriele, Fasano, A, and DE MAGISTRIS, Laura

Subjects
Celiac disease, small bowel disease
Abstract

Background and aim: Reaction to gluten can involve either an allergic [wheat allergy], or non-allergic [gluten sensitivity (GS)], or an autoimmune [celiac disease (CD)] mechanism. Recent evidences suggest that early changes in intestinal permeability (IP) may play a pivotal role in the pathogenesis of CD. Conversely, no data are available on the role of IP in the pathogenesis of GS. Aims of the present progress were to investigate the changes in IP, TJ protein genes expression and TLRs in GS and to establish whether these changes are related to an over expression of inflammatory cytokines. Material and methods: Biopsy samples were obtained from 17 GS patients (pts), 27 pts with active CD, 5 pts with CD in remission, and 11 healthy controls (age range: 5-50 years). Quantitative gene expression of TJ proteins Claudin (CL) 1, CL2, CL3, CL4, ZO-1 and of TLR1, TLR2 and TLR4 were performed by Real-time PCR. IP was evaluated by lactulose/mannitol test (LA/MA). Cytofluorimetric analyses of IL6, IL8, TNFa, IFNγ were conducted on PBMC of all patients. Results: CL1, CL3 and CL4 expression were significantly increased in GS subjects compared to healthy controls, while no changes in CL2, ZO-1 and Occludin expression were detected. This up-regulation did not influence IP, since in GS patients IP (0.017±0.012) was similar to that detected in healthy controls (0.016±0.010). Conversely, in active CD patients a significant over-expression of CL1 and CL2 was observed. The increased expression of CL1/2 was associated to an increase in IP (0.202±0.55). To evaluate if the innate immune system is involved in the pathogenesis of GS, TLRs expression was measured in a subgroup of patients. TLR1, but not TLR2 and TLR4, resulted significantly increased in CD (p=0,027) and in GS (p=0,0039) in respect to normal controls. Preliminary results showed that in GS patients up-regulation of CL was associated to increased expression of IL6 and IL8. Conclusions: Compared to CD patients, GS subjects showed normal IP and CL2 expression, while the other CL tested were up-regulated. These data suggest different pathogenic mechanisms in the two conditions,i.e., in GS loss of intestinal barrier function is not involved. The over expression of TLR 1 in CD and GS could suggest an important role of innate immune system in both conditions. Gluten Sensitivity appears to be a new chapter in the book of “Food intolerance” to be investigated

Published
2008

21. INTESTINAL INVOLVMENT IN AUTISTIC DISORDER: PROGRESS OF RESEARCH

Author

FAMILIARI V, DE MAGISTRIS, Laura, SAPONE A, RIEGLER, Gabriele, CARTENÌ M, IARDINO P, CARAVELLI G, BRAVACCIO C, FROLLI A, MILITERNI R, PASCOTTO, Antonio, Familiari, V, Demagistris, L, Sapone, A, Riegler, G, Cartenì, M, Iardino, P, Caravelli, G, Bravaccio, Carmela, Frolli, A, Militerni, R, Pascotto, A., DE MAGISTRIS, Laura, Riegler, Gabriele, Bravaccio, C, and Pascotto, Antonio

Published
2008

22. Role of the Innate Immune System in the Pathogenesis of Gluten Sensitivity : Preliminary Study

Author

Sapone A, Imbrici L, Giuliano MT, Cammarota M, De Rosa M, Cartenì M, TOLONE, Carlo, Familiari V, Lammers K, DE MAGISTRIS, Laura, Fasano A, RIEGLER, Gabriele, PAPPARELLA, Alfonso, Sapone, A, Imbrici, L, Giuliano, Mt, Cammarota, M, De Rosa, M, Cartenì, M, Tolone, Carlo, Papparella, Alfonso, Familiari, V, Lammers, K, DE MAGISTRIS, Laura, Fasano, A, and Riegler, Gabriele

Abstract

de Magistris, Alessio Fasano, Gabriele Riegler Background: Reaction to gluten can involve either an allergic (wheat allergy), or nonallergic [gluten sensitivity (GS)], or an autoimmune [celiac disease (CD)] mechanism. Recent evidences suggest that early changes in intestinal permeability (IP) may play a pivotal role in the pathogenesis of CD. Conversely, no data are available on the role of IP in the pathogenesis of GS. Aims: To investigate the changes in IP, TJ protein genes expression and TLRs in GS and to establish whether these changes are related to an over expression of inflammatory cytokines. Methods: After obtaining informed consent, biopsy samples were obtained from 17 GS patients (pts), 27 pts with active CD, 5 pts with CD in remission, and 11 healthy controls (age range: 5 years -50 years). Quantitative gene expression of TJ proteins Claudin (CL) 1, CL2, CL3, CL4, ZO-1 and of TLR1, TLR2 and TLR4 were performed by Real-time PCR. IP was evaluated by means of the lactulose/mannitol test (LA/MA). Cytofluorimetric analyses of IL6, IL8, TNFα, IFNγ were conducted on PBMC of all patients. Results: Expression of CL1, CL3 and CL4 were significantly increased in GS subjects compared to healthy controls, while no changes in CL2, ZO-1 and Occludin expression were detected. This up-regulation did not influence IP, since in GS patients IP (0.017±0.012) was similar to that detected in healthy controls (0.016±0.010). Conversely, in CD patients a significant over-expression of CL1 and CL2 was observed, while no significant changes in the other TJ proteins were detected. The increased expression of CL1/2 was associated to an increase in IP (0.202±0.55). In CD patients in remission both IP (0.014±0.004) and CL1/2 expression returned to normal levels. To evaluate if the innate immune system is involved in the pathogenesis of GS, TLRs expression was measured in a subgroup of patients. TLR1, but not TLR2 and TLR4, resulted significantly increased in CD (p=0,027) and in the GS (p=0,0039) respect to normal controls. Preliminary results showed that in GS patients up-regulation of CL was associated to increased expression of IL6 and IL8. Conclusions: Compared to CD patients, GS subjects showed normal IP and CL2 expression, while the other CL tested were up-regulated. These data suggest different pathogenic mechanisms in the two conditions, i.e., in GS loss of intestinal barrier function is not involved. The over expression of TLR 1 in CD and GS could suggest an important role of innate immune system in both conditions. Gluten Sensitivity appears to be a new chapter in the book of “Food intolerance” to be investigated.

Published
2008

24. PERMEABILITA’ INTESTINALE NEL DISTURBO AUTISTICO

Author

Familiari V, deMagistris L, Sapone A, Riegler G, Cartenì M, Iardino P, Frolli A, Militerni R, Pascotto A., BRAVACCIO, CARMELA, Familiari, V, Demagistris, L, Sapone, A, Riegler, G, Cartenì, M, Iardino, P, Bravaccio, Carmela, Frolli, A, Militerni, R, and Pascotto, A.

Published
2007

25. INTESTINAL PERMEABILITY IN AUTISTIC DISORDER

Author

FAMILIARI V, DE MAGISTRIS, Laura, SAPONE A, ESPOSITO R, RIEGLER, Gabriele, CARTENÌ M, GENEROSO M, IARDINO P, GUARDASCIONE T, BRAVACCIO C, FROLLI A, MILITERNI R, PASCOTTO, Antonio, Familiari, V, Demagistris, L, Sapone, A, Esposito, R, Riegler, G, Cartenì, M, Generoso, M, Iardino, P, Guardascione, T, Bravaccio, Carmela, Frolli, A, Militerni, R, Pascotto, A., DE MAGISTRIS, Laura, Riegler, Gabriele, Bravaccio, C, and Pascotto, Antonio

Published
2007

27. Permeabilità intestinale e malattie epatiche

Author

Fiandra R., DE MAGISTRIS, Laura, Generoso M., Belletta M., D’Auria M. V., D'Angelo R., Salerno R., Cartenì M., Carratù R., LOGUERCIO, Carmelina, FEDERICO, Alessandro, Fiandra, R., DE MAGISTRIS, Laura, Generoso, M., Belletta, M., D’Auria, M. V., D'Angelo, R., Federico, Alessandro, Salerno, R., Cartenì, M., Carratù, R., and Loguercio, Carmelina

Published
2003

29. Diabetes mellitus type 1 (dm1): a new enteropathy?

Author

Secondulfo M, DE MAGISTRIS, Laura, Sapone A, Fiandra R, Belletta M, Cartenì M, Generoso M, Prisco F, Esposito V, Carratù R., IAFUSCO, Dario, Secondulfo, M, DE MAGISTRIS, Laura, Sapone, A, Fiandra, R, Belletta, M, Cartenì, M, Generoso, M, Iafusco, Dario, Prisco, F, Esposito, V, and Carratù, R.

Published
2002

32. Diabete Mellito Tipo 1 ed alterazione dei tests di permeabilità intestinale

Author

IAFUSCO, Dario, DE MAGISTRIS, Laura, Ingenito N, Carpinelli L, Maglione E, Esposito V, Generoso M, Secondulfo M, Sapone A, Cartenì M, Carratù R, Corsi I, Iafusco M., Iafusco, Dario, DE MAGISTRIS, Laura, Ingenito, N, Carpinelli, L, Maglione, E, Esposito, V, Generoso, M, Secondulfo, M, Sapone, A, Cartenì, M, Carratù, R, Corsi, I, and Iafusco, M.

Published
2000

37. In vitro stimulatory effect of anti-apoptotic seminal vescicle protein 4 on purified peroxidase enzymes

Author

Metafora V, Stiuso P, Ferranti P, Giannattasio A, Dicitore A, Ravagnan G, De Maria S, Pontoni G, Cartenì M, Metafora S, Metafora, V., Stiuso, P., Ferranti, Pasquale, Giannattasio, A., Dicitore, A., Ravagnan, G., DE MARIA, S., Pontoni, G., Carteni, M., Metafora, S., Stiuso, Paola, Ferranti, P., and Carteni', M.

Subjects
reactive oxygen species, anti-ROS cell protection, enzymatic kinetics, peroxidase stimulation, protein SV-IV, enzymatic kinetic
Abstract

The enzymatic activities of purified horseradish peroxidase, selenium-dependent glutathione peroxidase, thyroid peroxidase and myeloperoxidase, but not that of lactoperoxidase, were markedly enhanced when added into a reaction mixture containing 5 lm native seminal vesicle protein 4, a major protein secreted from rat seminal vesicle epithelium. A further increase of horseradish peroxidase activity was obtained using Ser58-phosphorylated or acetylated seminal vesicle protein 4. The activating effect of native seminal vesicle protein 4 was highest (about 60-fold) on horseradish peroxidase when 4-chloro-1-naphtol was used as the electron donor substrate. The main kinetics parameters of the stimulatory effect on horseradish peroxidase were evaluated and the enzyme–electron donor substrate interaction was investigated by HPLC and electrospray-MS. A native seminal vesicle protein 4 ⁄ 4-chloro-1-naphtol noncovalent adduct was detected when the protein and 4-chloro-1-naphtol were present in the appropriate molar ratio in the horseradish peroxidase-catalyzed reaction. By contrast, no adducts were formed between native seminal vesicle protein 4 and horseradish peroxidase. This native seminal vesicle protein 4 ⁄ 4-chloro-1-naphtol interaction might underlie the native seminal vesicle protein 4-induced horseradish peroxidase stimulation. Furthermore, native seminal vesicle protein 4 was shown by spectrophotometric and electrospray-MS analysis to interact with NADPH, an electron donor substrate of the selenium-dependent glutathione peroxidase ⁄ glutathione reductase redox system, with formation of an adduct between them. Although further investigation is required to elucidate the mechanism of adduct formation, this interaction, probably by promoting the release of the NADPH electrons required for glutathione disulphide reduction, could explain the stimulatory effect of seminal vesicle protein 4 on mammalian peroxidases possibly involved in its physiological function on the selenium-dependent glutathione peroxidase ⁄ glutathione reductase system. The biological significance of these properties of native seminal vesicle protein 4 might be related to its ability to downregulate reactive oxygen species and oxidative stress-induced apoptosis.

Published
2008

47. PO.11 INTESTINAL INVOLVEMENT IN AUTISTIC DISORDER: PROGRESS OF RESEARCH

Author

Familiari, V., primary, Sapone, A., additional, Cartenì, M., additional, Iardino, P., additional, Caravelli, G., additional, Cariello, R., additional, Martorelli, L., additional, Bravaccio, C., additional, Frolli, A., additional, Militerni, R., additional, Pascotto, A., additional, Riegler, G., additional, and de Magistris, L., additional

Published
2008
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48. PA.39 ROLE OF TLR PATHWAY IN THE PATHOGENESIS OF GLUTEN SENSITIVITY: PRELIMINARY STUDY

Author

Sapone, A., primary, Imbrici, L., additional, Giuliano, M.T., additional, Cammarota, M., additional, De Rosa, M., additional, Cartenì, M., additional, Cariello, R., additional, Caravelli, G., additional, Martorelli, L., additional, Tolone, C., additional, Papparella, A., additional, Familiari, V., additional, Riegler, G., additional, Fasano, A., additional, and de Magistris, L., additional

Published
2008
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49. Intestinal permeability is decreased in anorexia nervosa

Author

Monteleone, P, primary, Carratù, R, additional, Cartenì, M, additional, Generoso, M, additional, Lamberti, M, additional, Magistris, L De, additional, Brambilla, F, additional, Colurcio, B, additional, Secondulfo, M, additional, and Maj, M, additional

Published
2003
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