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1. Fruits and vegetables intake and bladder cancer risk: a pooled analysis from 11 case–control studies in the BLadder cancer Epidemiology and Nutritional Determinants (BLEND) consortium

Author

Boot, Iris W. A., Wesselius, Anke, Jochems, Sylvia H. J., Yu, Evan Y. W., Bosetti, Cristina, Taborelli, Martina, Porru, Stefano, Carta, Angela, Golka, Klaus, Jiang, Xuejuan, Stern, Mariana C., Kellen, Eliane, Pohlabeln, Hermann, Tang, Li, Karagas, Margaret R., Zhang, Zuo-Feng, Taylor, Jack A., La Vecchia, Carlo, and Zeegers, Maurice P.

Published
2024
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2. Protective role of SARS-CoV-2 anti-S IgG against breakthrough infections among European healthcare workers during pre and post-Omicron surge—ORCHESTRA project

Author

Spiteri, Gianluca, D’Agostini, Marika, Abedini, Mahsa, Ditano, Giorgia, Collatuzzo, Giulia, Boffetta, Paolo, Vimercati, Luigi, Sansone, Emanuele, De Palma, Giuseppe, Modenese, Alberto, Gobba, Fabriziomaria, Liviero, Filippo, Moretto, Angelo, dell’Omo, Marco, Fiordi, Tiziana, Larese Filon, Francesca, Mauro, Marcella, Violán, Concepción, Mates, Dana, Oravec Bérešová, Jana, Monaco, Maria Grazia Lourdes, Carta, Angela, Verlato, Giuseppe, and Porru, Stefano

Published
2024
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4. Incidence and Determinants of Symptomatic and Asymptomatic SARS-CoV-2 Breakthrough Infections After Booster Dose in a Large European Multicentric Cohort of Health Workers-ORCHESTRA Project

Author

Porru, Stefano, Monaco, Maria Grazia Lourdes, Spiteri, Gianluca, Carta, Angela, Caliskan, Gulser, Violán, Concepción, Torán-Monserrat, Pere, Vimercati, Luigi, Tafuri, Silvio, Boffetta, Paolo, Violante, Francesco Saverio, Sala, Emma, Sansone, Emanuele, Gobba, Fabriziomaria, Casolari, Loretta, Wieser, Andreas, Janke, Christian, Tardon, Adonina, Rodriguez-Suarez, Marta Maria, Liviero, Filippo, Scapellato, Maria Luisa, dell’Omo, Marco, Murgia, Nicola, Mates, Dana, Calota, Violeta Claudia, Strhársky, Jozef, Mrázová, Mariana, Pira, Enrico, Godono, Alessandro, Magnano, Greta Camilla, Negro, Corrado, and Verlato, Giuseppe

Published
2023
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6. Genome-wide Association Study of Bladder Cancer Reveals New Biological and Translational Insights

Author

Koutros, Stella, Kiemeney, Lambertus A., Pal Choudhury, Parichoy, Milne, Roger L., Lopez de Maturana, Evangelina, Ye, Yuanqing, Joseph, Vijai, Florez-Vargas, Oscar, Dyrskjøt, Lars, Figueroa, Jonine, Dutta, Diptavo, Giles, Graham G., Hildebrandt, Michelle A.T., Offit, Kenneth, Kogevinas, Manolis, Weiderpass, Elisabete, McCullough, Marjorie L., Freedman, Neal D., Albanes, Demetrius, Kooperberg, Charles, Cortessis, Victoria K., Karagas, Margaret R., Johnson, Alison, Schwenn, Molly R., Baris, Dalsu, Furberg, Helena, Bajorin, Dean F., Cussenot, Olivier, Cancel-Tassin, Geraldine, Benhamou, Simone, Kraft, Peter, Porru, Stefano, Carta, Angela, Bishop, Timothy, Southey, Melissa C., Matullo, Giuseppe, Fletcher, Tony, Kumar, Rajiv, Taylor, Jack A., Lamy, Philippe, Prip, Frederik, Kalisz, Mark, Weinstein, Stephanie J., Hengstler, Jan G., Selinski, Silvia, Harland, Mark, Teo, Mark, Kiltie, Anne E., Tardón, Adonina, Serra, Consol, Carrato, Alfredo, García-Closas, Reina, Lloreta, Josep, Schned, Alan, Lenz, Petra, Riboli, Elio, Brennan, Paul, Tjønneland, Anne, Otto, Thomas, Ovsiannikov, Daniel, Volkert, Frank, Vermeulen, Sita H., Aben, Katja K., Galesloot, Tessel E., Turman, Constance, De Vivo, Immaculata, Giovannucci, Edward, Hunter, David J., Hohensee, Chancellor, Hunt, Rebecca, Patel, Alpa V., Huang, Wen-Yi, Thorleifsson, Gudmar, Gago-Dominguez, Manuela, Amiano, Pilar, Golka, Klaus, Stern, Mariana C., Yan, Wusheng, Liu, Jia, Li, Shengchao Alfred, Katta, Shilpa, Hutchinson, Amy, Hicks, Belynda, Wheeler, William A., Purdue, Mark P., McGlynn, Katherine A., Kitahara, Cari M., Haiman, Christopher A., Greene, Mark H., Rafnar, Thorunn, Chatterjee, Nilanjan, Chanock, Stephen J., Wu, Xifeng, Real, Francisco X., Silverman, Debra T., Garcia-Closas, Montserrat, Stefansson, Kari, Prokunina-Olsson, Ludmila, Malats, Núria, and Rothman, Nathaniel

Published
2023
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7. A data mining approach to investigate food groups related to incidence of bladder cancer in the BLadder cancer Epidemiology and Nutritional Determinants International Study

Author

Yu, Evan YW, Wesselius, Anke, Sinhart, Christoph, Wolk, Alicja, Stern, Mariana Carla, Jiang, Xuejuan, Tang, Li, Marshall, James, Kellen, Eliane, van den Brandt, Piet, Lu, Chih-Ming, Pohlabeln, Hermann, Steineck, Gunnar, Allam, Mohamed Farouk, Karagas, Margaret R, La Vecchia, Carlo, Porru, Stefano, Carta, Angela, Golka, Klaus, Johnson, Kenneth C, Benhamou, Simone, Zhang, Zuo-Feng, Bosetti, Cristina, Taylor, Jack A, Weiderpass, Elisabete, Grant, Eric J, White, Emily, Polesel, Jerry, and Zeegers, Maurice PA

Subjects
Cancer, Nutrition, Prevention, Urologic Diseases, Prevention of disease and conditions, and promotion of well-being, 3.3 Nutrition and chemoprevention, Stroke, Cardiovascular, Algorithms, Case-Control Studies, Data Mining, Diet, Female, Food, Humans, Incidence, Internationality, Male, Risk Factors, Urinary Bladder Neoplasms, Bladder cancer, Data mining, Food groups, Epidemiological studies, Animal Production, Food Sciences, Nutrition and Dietetics, Nutrition & Dietetics
Abstract

At present, analysis of diet and bladder cancer (BC) is mostly based on the intake of individual foods. The examination of food combinations provides a scope to deal with the complexity and unpredictability of the diet and aims to overcome the limitations of the study of nutrients and foods in isolation. This article aims to demonstrate the usability of supervised data mining methods to extract the food groups related to BC. In order to derive key food groups associated with BC risk, we applied the data mining technique C5.0 with 10-fold cross-validation in the BLadder cancer Epidemiology and Nutritional Determinants study, including data from eighteen case-control and one nested case-cohort study, compromising 8320 BC cases out of 31 551 participants. Dietary data, on the eleven main food groups of the Eurocode 2 Core classification codebook, and relevant non-diet data (i.e. sex, age and smoking status) were available. Primarily, five key food groups were extracted; in order of importance, beverages (non-milk); grains and grain products; vegetables and vegetable products; fats, oils and their products; meats and meat products were associated with BC risk. Since these food groups are corresponded with previously proposed BC-related dietary factors, data mining seems to be a promising technique in the field of nutritional epidemiology and deserves further examination.

Published
2020

8. Modeling the complex exposure history of smoking in predicting bladder cancer

Author

van Osch, Frits HM, Vlaanderen, Jelle, Jochems, Sylvia HJ, Bosetti, Cristina, Polesel, Jerry, Porru, Stefano, Carta, Angela, Golka, Klaus, Jiang, Xuejuan, Stern, Mariana C, Zhong, Wei-De, Kellen, Eliane, Pohlabeln, Hermann, Tang, Li, Marshall, James, Steineck, Gunnar, Karagas, Margaret R, Johnson, Kenneth C, Zhang, Zuo-Feng, Taylor, Jack A, La Vecchia, Carlo, Bryan, Richard T, van Schooten, Frederik J, Wesselius, Anke, and Zeegers, Maurice P

Subjects
Epidemiology, Health Sciences, Tobacco, Tobacco Smoke and Health, Cancer, Urologic Diseases, Prevention, Aetiology, 2.2 Factors relating to the physical environment, Case-Control Studies, Female, Humans, Male, Models, Biological, Risk Factors, Smoking, Time Factors, Urinary Bladder Neoplasms, Bladder cancer, Cancer risk, Pooled analysis, Smoking history, statistical modeling, Statistics, Public Health and Health Services, Public health
Abstract

BackgroundFew studies have modeled smoking histories by combining smoking intensity and duration to show what profile of smoking behavior is associated with highest risk of bladder cancer. This study aims to provide insight into the association between smoking exposure history and bladder cancer risk by modeling both smoking intensity and duration in a pooled analysis.MethodsWe used data from 15 case-control studies included in the bladder cancer epidemiology and nutritional determinants study, including a total of 6,874 cases and 17,727 controls. To jointly interpret the effects of intensity and duration of smoking, we modeled excess odds ratios per pack-year by intensity continuously to estimate the risk difference between smokers with long duration/low intensity and short duration/high intensity.ResultsThe pattern observed from the pooled excess odds ratios model indicated that for a fixed number of pack-years, smoking for a longer duration at lower intensity was more deleterious for bladder cancer risk than smoking more cigarettes/day for a shorter duration. We observed similar patterns within individual study samples.ConclusionsThis pooled analysis shows that long duration/low intensity smoking is associated with a greater increase in bladder cancer risk than short duration/high intensity smoking within equal pack-year categories, thus confirming studies in other smoking-related cancers and demonstrating that reducing exposure history to a single metric such as pack-years was too restrictive.

Published
2019

10. International pooled study on diet and bladder cancer: the bladder cancer, epidemiology and nutritional determinants (BLEND) study: design and baseline characteristics

Author

Goossens, Maria E, Isa, Fatima, Brinkman, Maree, Mak, David, Reulen, Raoul, Wesselius, Anke, Benhamou, Simone, Bosetti, Cristina, Bueno-de-Mesquita, Bas, Carta, Angela, Allam, Md Farouk, Golka, Klaus, Grant, Eric J, Jiang, Xuejuan, Johnson, Kenneth C, Karagas, Margaret R, Kellen, Eliane, La Vecchia, Carlo, Lu, Chih-Ming, Marshall, James, Moysich, Kirsten, Pohlabeln, Hermann, Porru, Stefano, Steineck, Gunnar, Stern, Marianne C, Tang, Li, Taylor, Jack A, van den Brandt, Piet, Villeneuve, Paul J, Wakai, Kenji, Weiderpass, Elisabete, White, Emily, Wolk, Alicja, Zhang, Zuo-Feng, Buntinx, Frank, and Zeegers, Maurice P

Subjects
Public Health, Health Sciences, Cancer, Nutrition, Prevention, Urologic Diseases, Aetiology, 2.2 Factors relating to the physical environment, Bladder cancer, Diet, Risk, Pooled analysis, Public Health and Health Services, Epidemiology, Midwifery, Public health
Abstract

BackgroundIn 2012, more than 400,000 urinary bladder cancer cases occurred worldwide, making it the 7(th) most common type of cancer. Although many previous studies focused on the relationship between diet and bladder cancer, the evidence related to specific food items or nutrients that could be involved in the development of bladder cancer remains inconclusive. Dietary components can either be, or be activated into, potential carcinogens through metabolism, or act to prevent carcinogen damage.Methods/designThe BLadder cancer, Epidemiology and Nutritional Determinants (BLEND) study was set up with the purpose of collecting individual patient data from observational studies on diet and bladder cancer. In total, data from 11,261 bladder cancer cases and 675,532 non-cases from 18 case-control and 6 cohort studies from all over the world were included with the aim to investigate the association between individual food items, nutrients and dietary patterns and risk of developing bladder cancer.DiscussionThe substantial number of cases included in this study will enable us to provide evidence with large statistical power, for dietary recommendations on the prevention of bladder cancer.

Published
2016

11. Nursing Home Manager Role in Managing Aging Workers: A Qualitative Research in Nursing Homes

Author

Denise, Massenti, Carta, Angela, Cadei, Livia, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Bagnara, Sebastiano, editor, Tartaglia, Riccardo, editor, Albolino, Sara, editor, Alexander, Thomas, editor, and Fujita, Yushi, editor

Published
2019
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12. Management of Psychosocial Work Environment: Outline of a Multidisciplinary Preventive Intervention in a Large North Italian Municipality

Author

Carta, Angela, Manfredi, Paola, Porru, Stefano, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Bagnara, Sebastiano, editor, Tartaglia, Riccardo, editor, Albolino, Sara, editor, Alexander, Thomas, editor, and Fujita, Yushi, editor

Published
2019
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13. Identification of a novel susceptibility locus at 13q34 and refinement of the 20p12.2 region as a multi-signal locus associated with bladder cancer risk in individuals of European ancestry

Author

Figueroa, Jonine D, Middlebrooks, Candace D, Banday, A Rouf, Ye, Yuanqing, Garcia-Closas, Montserrat, Chatterjee, Nilanjan, Koutros, Stella, Kiemeney, Lambertus A, Rafnar, Thorunn, Bishop, Timothy, Furberg, Helena, Matullo, Giuseppe, Golka, Klaus, Gago-Dominguez, Manuela, Taylor, Jack A, Fletcher, Tony, Siddiq, Afshan, Cortessis, Victoria K, Kooperberg, Charles, Cussenot, Olivier, Benhamou, Simone, Prescott, Jennifer, Porru, Stefano, Dinney, Colin P, Malats, Núria, Baris, Dalsu, Purdue, Mark P, Jacobs, Eric J, Albanes, Demetrius, Wang, Zhaoming, Chung, Charles C, Vermeulen, Sita H, Aben, Katja K, Galesloot, Tessel E, Thorleifsson, Gudmar, Sulem, Patrick, Stefansson, Kari, Kiltie, Anne E, Harland, Mark, Teo, Mark, Offit, Kenneth, Vijai, Joseph, Bajorin, Dean, Kopp, Ryan, Fiorito, Giovanni, Guarrera, Simonetta, Sacerdote, Carlotta, Selinski, Silvia, Hengstler, Jan G, Gerullis, Holger, Ovsiannikov, Daniel, Blaszkewicz, Meinolf, Castelao, Jose Esteban, Calaza, Manuel, Martinez, Maria Elena, Cordeiro, Patricia, Xu, Zongli, Panduri, Vijayalakshmi, Kumar, Rajiv, Gurzau, Eugene, Koppova, Kvetoslava, Bueno-De-Mesquita, H Bas, Ljungberg, Börje, Clavel-Chapelon, Françoise, Weiderpass, Elisabete, Krogh, Vittorio, Dorronsoro, Miren, Travis, Ruth C, Tjønneland, Anne, Brennan, Paul, Chang-Claude, Jenny, Riboli, Elio, Conti, David, Stern, Marianna C, Pike, Malcolm C, Van Den Berg, David, Yuan, Jian-Min, Hohensee, Chancellor, Jeppson, Rebecca P, Cancel-Tassin, Geraldine, Roupret, Morgan, Comperat, Eva, Turman, Constance, De Vivo, Immaculata, Giovannucci, Edward, Hunter, David J, Kraft, Peter, Lindstrom, Sara, Carta, Angela, Pavanello, Sofia, Arici, Cecilia, Mastrangelo, Giuseppe, Kamat, Ashish M, Zhang, Liren, Gong, Yilei, Pu, Xia, Hutchinson, Amy, Burdett, Laurie, Wheeler, William A, and Karagas, Margaret R

Subjects
Cancer, Prevention, Human Genome, Genetics, Biotechnology, Urologic Diseases, Aetiology, 2.1 Biological and endogenous factors, Biomarkers, Tumor, Case-Control Studies, Chromosomes, Human, Pair 13, Chromosomes, Human, Pair 20, Female, Genetic Association Studies, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Linkage Disequilibrium, Male, Polymorphism, Single Nucleotide, Risk Factors, Urinary Bladder Neoplasms, White People, Biological Sciences, Medical and Health Sciences, Genetics & Heredity
Abstract

Candidate gene and genome-wide association studies (GWAS) have identified 15 independent genomic regions associated with bladder cancer risk. In search for additional susceptibility variants, we followed up on four promising single-nucleotide polymorphisms (SNPs) that had not achieved genome-wide significance in 6911 cases and 11 814 controls (rs6104690, rs4510656, rs5003154 and rs4907479, P < 1 × 10(-6)), using additional data from existing GWAS datasets and targeted genotyping for studies that did not have GWAS data. In a combined analysis, which included data on up to 15 058 cases and 286 270 controls, two SNPs achieved genome-wide statistical significance: rs6104690 in a gene desert at 20p12.2 (P = 2.19 × 10(-11)) and rs4907479 within the MCF2L gene at 13q34 (P = 3.3 × 10(-10)). Imputation and fine-mapping analyses were performed in these two regions for a subset of 5551 bladder cancer cases and 10 242 controls. Analyses at the 13q34 region suggest a single signal marked by rs4907479. In contrast, we detected two signals in the 20p12.2 region-the first signal is marked by rs6104690, and the second signal is marked by two moderately correlated SNPs (r(2) = 0.53), rs6108803 and the previously reported rs62185668. The second 20p12.2 signal is more strongly associated with the risk of muscle-invasive (T2-T4 stage) compared with non-muscle-invasive (Ta, T1 stage) bladder cancer (case-case P ≤ 0.02 for both rs62185668 and rs6108803). Functional analyses are needed to explore the biological mechanisms underlying these novel genetic associations with risk for bladder cancer.

Published
2016

15. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types

Author

Sampson, Joshua N, Wheeler, William A, Yeager, Meredith, Panagiotou, Orestis, Wang, Zhaoming, Berndt, Sonja I, Lan, Qing, Abnet, Christian C, Amundadottir, Laufey T, Figueroa, Jonine D, Landi, Maria Teresa, Mirabello, Lisa, Savage, Sharon A, Taylor, Philip R, De Vivo, Immaculata, McGlynn, Katherine A, Purdue, Mark P, Rajaraman, Preetha, Adami, Hans-Olov, Ahlbom, Anders, Albanes, Demetrius, Amary, Maria Fernanda, An, She-Juan, Andersson, Ulrika, Andriole, Gerald, Andrulis, Irene L, Angelucci, Emanuele, Ansell, Stephen M, Arici, Cecilia, Armstrong, Bruce K, Arslan, Alan A, Austin, Melissa A, Baris, Dalsu, Barkauskas, Donald A, Bassig, Bryan A, Becker, Nikolaus, Benavente, Yolanda, Benhamou, Simone, Berg, Christine, Van Den Berg, David, Bernstein, Leslie, Bertrand, Kimberly A, Birmann, Brenda M, Black, Amanda, Boeing, Heiner, Boffetta, Paolo, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Brinton, Louise, Brooks-Wilson, Angela R, Bueno-de-Mesquita, H Bas, Burdett, Laurie, Buring, Julie, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chan, John KC, Chang, Ellen T, Chang, Gee-Chen, Chang, I-Shou, Chang, Jiang, Chang-Claude, Jenny, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chu, Chen, Chung-Hsing, Chen, Constance, Chen, Hongyan, Chen, Kexin, Chen, Kuan-Yu, Chen, Kun-Chieh, Chen, Ying, Chen, Ying-Hsiang, Chen, Yi-Song, Chen, Yuh-Min, Chien, Li-Hsin, Chirlaque, María-Dolores, Choi, Jin Eun, Choi, Yi Young, Chow, Wong-Ho, Chung, Charles C, Clavel, Jacqueline, Clavel-Chapelon, Françoise, Cocco, Pierluigi, Colt, Joanne S, Comperat, Eva, Conde, Lucia, Connors, Joseph M, Conti, David, Cortessis, Victoria K, Cotterchio, Michelle, Cozen, Wendy, Crouch, Simon, Crous-Bou, Marta, Cussenot, Olivier, and Davis, Faith G

Subjects
Tobacco, Clinical Research, Urologic Diseases, Lung, Genetics, Rare Diseases, Lung Cancer, Human Genome, Hematology, Cancer, Tobacco Smoke and Health, Prevention, Lymphoma, Adult, Aged, Asian People, Bone Neoplasms, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Kidney Neoplasms, Leukemia, Lymphocytic, Chronic, B-Cell, Lung Neoplasms, Lymphoma, Large B-Cell, Diffuse, Male, Middle Aged, Neoplasms, Osteosarcoma, Polymorphism, Single Nucleotide, Smoking, Testicular Neoplasms, Tissue Array Analysis, Urinary Bladder Neoplasms, White People, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

BackgroundStudies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites.MethodsBetween 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers.ResultsGWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, hl (2), on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (ρ = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (ρ = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (ρ = 0.51, SE =0.18), and bladder and lung (ρ = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures.ConclusionOur results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.

Published
2015

16. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types.

Author

Sampson, Joshua N, Wheeler, William A, Yeager, Meredith, Panagiotou, Orestis, Wang, Zhaoming, Berndt, Sonja I, Lan, Qing, Abnet, Christian C, Amundadottir, Laufey T, Figueroa, Jonine D, Landi, Maria Teresa, Mirabello, Lisa, Savage, Sharon A, Taylor, Philip R, De Vivo, Immaculata, McGlynn, Katherine A, Purdue, Mark P, Rajaraman, Preetha, Adami, Hans-Olov, Ahlbom, Anders, Albanes, Demetrius, Amary, Maria Fernanda, An, She-Juan, Andersson, Ulrika, Andriole, Gerald, Andrulis, Irene L, Angelucci, Emanuele, Ansell, Stephen M, Arici, Cecilia, Armstrong, Bruce K, Arslan, Alan A, Austin, Melissa A, Baris, Dalsu, Barkauskas, Donald A, Bassig, Bryan A, Becker, Nikolaus, Benavente, Yolanda, Benhamou, Simone, Berg, Christine, Van Den Berg, David, Bernstein, Leslie, Bertrand, Kimberly A, Birmann, Brenda M, Black, Amanda, Boeing, Heiner, Boffetta, Paolo, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Brinton, Louise, Brooks-Wilson, Angela R, Bueno-de-Mesquita, H Bas, Burdett, Laurie, Buring, Julie, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chan, John KC, Chang, Ellen T, Chang, Gee-Chen, Chang, I-Shou, Chang, Jiang, Chang-Claude, Jenny, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chu, Chen, Chung-Hsing, Chen, Constance, Chen, Hongyan, Chen, Kexin, Chen, Kuan-Yu, Chen, Kun-Chieh, Chen, Ying, Chen, Ying-Hsiang, Chen, Yi-Song, Chen, Yuh-Min, Chien, Li-Hsin, Chirlaque, María-Dolores, Choi, Jin Eun, Choi, Yi Young, Chow, Wong-Ho, Chung, Charles C, Clavel, Jacqueline, Clavel-Chapelon, Françoise, Cocco, Pierluigi, Colt, Joanne S, Comperat, Eva, Conde, Lucia, Connors, Joseph M, Conti, David, Cortessis, Victoria K, Cotterchio, Michelle, Cozen, Wendy, Crouch, Simon, Crous-Bou, Marta, Cussenot, Olivier, and Davis, Faith G

Subjects
Humans, Neoplasms, Osteosarcoma, Bone Neoplasms, Testicular Neoplasms, Lung Neoplasms, Kidney Neoplasms, Genetic Predisposition to Disease, Tissue Array Analysis, Smoking, Polymorphism, Single Nucleotide, Adult, Aged, Middle Aged, Asian Continental Ancestry Group, European Continental Ancestry Group, Female, Male, Urinary Bladder Neoplasms, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large B-Cell, Diffuse, Genome-Wide Association Study, Polymorphism, Single Nucleotide, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large B-Cell, Diffuse, Oncology And Carcinogenesis, Oncology & Carcinogenesis, Oncology and Carcinogenesis
Abstract

BackgroundStudies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites.MethodsBetween 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers.ResultsGWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, hl (2), on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (ρ = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (ρ = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (ρ = 0.51, SE =0.18), and bladder and lung (ρ = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures.ConclusionOur results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.

Published
2015

17. Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33

Author

Wang, Zhaoming, Zhu, Bin, Zhang, Mingfeng, Parikh, Hemang, Jia, Jinping, Chung, Charles C, Sampson, Joshua N, Hoskins, Jason W, Hutchinson, Amy, Burdette, Laurie, Ibrahim, Abdisamad, Hautman, Christopher, Raj, Preethi S, Abnet, Christian C, Adjei, Andrew A, Ahlbom, Anders, Albanes, Demetrius, Allen, Naomi E, Ambrosone, Christine B, Aldrich, Melinda, Amiano, Pilar, Amos, Christopher, Andersson, Ulrika, Andriole, Gerald, Andrulis, Irene L, Arici, Cecilia, Arslan, Alan A, Austin, Melissa A, Baris, Dalsu, Barkauskas, Donald A, Bassig, Bryan A, Beane Freeman, Laura E, Berg, Christine D, Berndt, Sonja I, Bertazzi, Pier Alberto, Biritwum, Richard B, Black, Amanda, Blot, William, Boeing, Heiner, Boffetta, Paolo, Bolton, Kelly, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Brennan, Paul, Brinton, Louise A, Brotzman, Michelle, Bueno-de-Mesquita, H Bas, Buring, Julie E, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Cao, Guangwen, Caporaso, Neil E, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chang, Gee-Chen, Chang, I-Shou, Chang-Claude, Jenny, Che, Xu, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chung-Hsing, Chen, Constance, Chen, Kuan-Yu, Chen, Yuh-Min, Chokkalingam, Anand P, Chu, Lisa W, Clavel-Chapelon, Francoise, Colditz, Graham A, Colt, Joanne S, Conti, David, Cook, Michael B, Cortessis, Victoria K, Crawford, E David, Cussenot, Olivier, Davis, Faith G, De Vivo, Immaculata, Deng, Xiang, Ding, Ti, Dinney, Colin P, Di Stefano, Anna Luisa, Diver, W Ryan, Duell, Eric J, Elena, Joanne W, Fan, Jin-Hu, Feigelson, Heather Spencer, Feychting, Maria, Figueroa, Jonine D, Flanagan, Adrienne M, Fraumeni, Joseph F, Freedman, Neal D, Fridley, Brooke L, Fuchs, Charles S, Gago-Dominguez, Manuela, Gallinger, Steven, Gao, Yu-Tang, Gapstur, Susan M, and Garcia-Closas, Montserrat

Subjects
Biological Sciences, Genetics, Cancer, Clinical Research, Human Genome, Prevention, Aetiology, 2.1 Biological and endogenous factors, Alleles, Chromosomes, Human, Pair 5, Computational Biology, DNA Methylation, Epigenesis, Genetic, Female, Gene Expression Regulation, Neoplastic, Gene Frequency, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Male, Membrane Proteins, Neoplasm Proteins, Neoplasms, Odds Ratio, Polymorphism, Single Nucleotide, Risk, Telomerase, Medical and Health Sciences, Genetics & Heredity
Abstract

Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This region harbors the TERT and CLPTM1L genes; the former encodes the catalytic subunit of telomerase reverse transcriptase and the latter may play a role in apoptosis. To investigate further the genetic architecture of common susceptibility alleles in this region, we conducted an agnostic subset-based meta-analysis (association analysis based on subsets) across six distinct cancers in 34 248 cases and 45 036 controls. Based on sequential conditional analysis, we identified as many as six independent risk loci marked by common single-nucleotide polymorphisms: five in the TERT gene (Region 1: rs7726159, P = 2.10 × 10(-39); Region 3: rs2853677, P = 3.30 × 10(-36) and PConditional = 2.36 × 10(-8); Region 4: rs2736098, P = 3.87 × 10(-12) and PConditional = 5.19 × 10(-6), Region 5: rs13172201, P = 0.041 and PConditional = 2.04 × 10(-6); and Region 6: rs10069690, P = 7.49 × 10(-15) and PConditional = 5.35 × 10(-7)) and one in the neighboring CLPTM1L gene (Region 2: rs451360; P = 1.90 × 10(-18) and PConditional = 7.06 × 10(-16)). Between three and five cancers mapped to each independent locus with both risk-enhancing and protective effects. Allele-specific effects on DNA methylation were seen for a subset of risk loci, indicating that methylation and subsequent effects on gene expression may contribute to the biology of risk variants on 5p15.33. Our results provide strong support for extensive pleiotropy across this region of 5p15.33, to an extent not previously observed in other cancer susceptibility loci.

Published
2014

18. A Multi-Center Study Investigating Long COVID-19 in Healthcare Workers from North-Eastern Italy: Prevalence, Risk Factors and the Impact of Pre-Existing Humoral Immunity—ORCHESTRA Project

Author

Cegolon, Luca, primary, Mauro, Marcella, additional, Sansone, Donatella, additional, Tassinari, Alice, additional, Gobba, Fabrizio Maria, additional, Modenese, Alberto, additional, Casolari, Loretta, additional, Liviero, Filippo, additional, Pavanello, Sofia, additional, Scapellato, Maria Luisa, additional, Taus, Francesco, additional, Carta, Angela, additional, Spiteri, Gianluca, additional, Monaco, Maria Grazia Lourdes, additional, Porru, Stefano, additional, and Larese Filon, Francesca, additional

Published
2023
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19. New insights on occupational exposure and bladder cancer risk: a pooled analysis of two Italian case–control studies

Author

Sciannameo, Veronica, Carta, Angela, d’Errico, Angelo, Giraudo, Maria Teresa, Fasanelli, Francesca, Arici, Cecilia, Maule, Milena, Carnà, Paolo, Destefanis, Paolo, Rolle, Luigi, Gontero, Paolo, Casetta, Giovanni, Zitella, Andrea, Cucchiarale, Giuseppina, Vineis, Paolo, Porru, Stefano, Sacerdote, Carlotta, and Ricceri, Fulvio

Published
2019
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20. Multimorbidity and Serological Response to SARS-CoV-2 Nine Months after 1st Vaccine Dose: European Cohort of Healthcare Workers—Orchestra Project

Author

Violán, Concepción, primary, Carrasco-Ribelles, Lucía A., additional, Collatuzzo, Giulia, additional, Ditano, Giorgia, additional, Abedini, Mahsa, additional, Janke, Christian, additional, Reinkemeyer, Christina, additional, Giang, Le Thi Thu, additional, Liviero, Filippo, additional, Scapellato, Maria Luisa, additional, Mauro, Marcella, additional, Rui, Francesca, additional, Porru, Stefano, additional, Spiteri, Gianluca, additional, Monaco, Maria Grazia Lourdes, additional, Carta, Angela, additional, Otelea, Marina, additional, Rascu, Agripina, additional, Fabiánová, Eleonóra, additional, Klöslová, Zuzana, additional, Boffetta, Paolo, additional, and Torán-Monserrat, Pere, additional

Published
2023
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22. Data from The 19q12 Bladder Cancer GWAS Signal: Association with Cyclin E Function and Aggressive Disease

Author

Fu, Yi-Ping, primary, Kohaar, Indu, primary, Moore, Lee E., primary, Lenz, Petra, primary, Figueroa, Jonine D., primary, Tang, Wei, primary, Porter-Gill, Patricia, primary, Chatterjee, Nilanjan, primary, Scott-Johnson, Alexandra, primary, Garcia-Closas, Montserrat, primary, Muchmore, Brian, primary, Baris, Dalsu, primary, Paquin, Ashley, primary, Ylaya, Kris, primary, Schwenn, Molly, primary, Apolo, Andrea B., primary, Karagas, Margaret R., primary, Tarway, McAnthony, primary, Johnson, Alison, primary, Mumy, Adam, primary, Schned, Alan, primary, Guedez, Liliana, primary, Jones, Michael A., primary, Kida, Masatoshi, primary, Hosain, GM Monawar, primary, Malats, Nuria, primary, Kogevinas, Manolis, primary, Tardon, Adonina, primary, Serra, Consol, primary, Carrato, Alfredo, primary, Garcia-Closas, Reina, primary, Lloreta, Josep, primary, Wu, Xifeng, primary, Purdue, Mark, primary, Andriole, Gerald L., primary, Grubb, Robert L., primary, Black, Amanda, primary, Landi, Maria T., primary, Caporaso, Neil E., primary, Vineis, Paolo, primary, Siddiq, Afshan, primary, Bueno-de-Mesquita, H. Bas, primary, Trichopoulos, Dimitrios, primary, Ljungberg, Börje, primary, Severi, Gianluca, primary, Weiderpass, Elisabete, primary, Krogh, Vittorio, primary, Dorronsoro, Miren, primary, Travis, Ruth C., primary, Tjønneland, Anne, primary, Brennan, Paul, primary, Chang-Claude, Jenny, primary, Riboli, Elio, primary, Prescott, Jennifer, primary, Chen, Constance, primary, De Vivo, Immaculata, primary, Govannucci, Edward, primary, Hunter, David, primary, Kraft, Peter, primary, Lindstrom, Sara, primary, Gapstur, Susan M., primary, Jacobs, Eric J., primary, Diver, W. Ryan, primary, Albanes, Demetrius, primary, Weinstein, Stephanie J., primary, Virtamo, Jarmo, primary, Kooperberg, Charles, primary, Hohensee, Chancellor, primary, Rodabough, Rebecca J., primary, Cortessis, Victoria K., primary, Conti, David V., primary, Gago-Dominguez, Manuela, primary, Stern, Mariana C., primary, Pike, Malcolm C., primary, Van Den Berg, David, primary, Yuan, Jian-Min, primary, Haiman, Christopher A., primary, Cussenot, Olivier, primary, Cancel-Tassin, Geraldine, primary, Roupret, Morgan, primary, Comperat, Eva, primary, Porru, Stefano, primary, Carta, Angela, primary, Pavanello, Sofia, primary, Arici, Cecilia, primary, Mastrangelo, Giuseppe, primary, Grossman, H. Barton, primary, Wang, Zhaoming, primary, Deng, Xiang, primary, Chung, Charles C., primary, Hutchinson, Amy, primary, Burdette, Laurie, primary, Wheeler, William, primary, Fraumeni, Joseph, primary, Chanock, Stephen J., primary, Hewitt, Stephen M., primary, Silverman, Debra T., primary, Rothman, Nathaniel, primary, and Prokunina-Olsson, Ludmila, primary

Published
2023
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23. Supplementary Figure Legend from Polymorphisms in DNA Repair Genes, Smoking, and Bladder Cancer Risk: Findings from the International Consortium of Bladder Cancer

Author

Stern, Mariana C., primary, Lin, Jie, primary, Figueroa, Jonine D., primary, Kelsey, Karl T., primary, Kiltie, Anne E., primary, Yuan, Jian-Min, primary, Matullo, Giuseppe, primary, Fletcher, Tony, primary, Benhamou, Simone, primary, Taylor, Jack A., primary, Placidi, Donatella, primary, Zhang, Zuo-Feng, primary, Steineck, Gunnar, primary, Rothman, Nathaniel, primary, Kogevinas, Manolis, primary, Silverman, Debra, primary, Malats, Nuria, primary, Chanock, Stephen, primary, Wu, Xifeng, primary, Karagas, Margaret R., primary, Andrew, Angeline S., primary, Nelson, Heather H., primary, Bishop, D. Timothy, primary, Sak, Sei Chung, primary, Choudhury, Ananya, primary, Barrett, Jennifer H., primary, Elliot, Faye, primary, Corral, Román, primary, Joshi, Amit D., primary, Gago-Dominguez, Manuela, primary, Cortessis, Victoria K., primary, Xiang, Yong-Bing, primary, Gao, Yu-Tang, primary, Vineis, Paolo, primary, Sacerdote, Carlotta, primary, Guarrera, Simonetta, primary, Polidoro, Silvia, primary, Allione, Alessandra, primary, Gurzau, Eugen, primary, Koppova, Kvetoslava, primary, Kumar, Rajiv, primary, Rudnai, Peter, primary, Porru, Stefano, primary, Carta, Angela, primary, Campagna, Marcello, primary, Arici, Cecilia, primary, Park, Sung Shim Lani, primary, and Garcia-Closas, Montserrat, primary

Published
2023
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24. Supplementary Tables 1-8 from Polymorphisms in DNA Repair Genes, Smoking, and Bladder Cancer Risk: Findings from the International Consortium of Bladder Cancer

Author

Stern, Mariana C., primary, Lin, Jie, primary, Figueroa, Jonine D., primary, Kelsey, Karl T., primary, Kiltie, Anne E., primary, Yuan, Jian-Min, primary, Matullo, Giuseppe, primary, Fletcher, Tony, primary, Benhamou, Simone, primary, Taylor, Jack A., primary, Placidi, Donatella, primary, Zhang, Zuo-Feng, primary, Steineck, Gunnar, primary, Rothman, Nathaniel, primary, Kogevinas, Manolis, primary, Silverman, Debra, primary, Malats, Nuria, primary, Chanock, Stephen, primary, Wu, Xifeng, primary, Karagas, Margaret R., primary, Andrew, Angeline S., primary, Nelson, Heather H., primary, Bishop, D. Timothy, primary, Sak, Sei Chung, primary, Choudhury, Ananya, primary, Barrett, Jennifer H., primary, Elliot, Faye, primary, Corral, Román, primary, Joshi, Amit D., primary, Gago-Dominguez, Manuela, primary, Cortessis, Victoria K., primary, Xiang, Yong-Bing, primary, Gao, Yu-Tang, primary, Vineis, Paolo, primary, Sacerdote, Carlotta, primary, Guarrera, Simonetta, primary, Polidoro, Silvia, primary, Allione, Alessandra, primary, Gurzau, Eugen, primary, Koppova, Kvetoslava, primary, Kumar, Rajiv, primary, Rudnai, Peter, primary, Porru, Stefano, primary, Carta, Angela, primary, Campagna, Marcello, primary, Arici, Cecilia, primary, Park, Sung Shim Lani, primary, and Garcia-Closas, Montserrat, primary

Published
2023
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25. Supplementary Materials, Figures 1 - 3, Tables 1 - 4, 6 - 8 from The 19q12 Bladder Cancer GWAS Signal: Association with Cyclin E Function and Aggressive Disease

Author

Fu, Yi-Ping, primary, Kohaar, Indu, primary, Moore, Lee E., primary, Lenz, Petra, primary, Figueroa, Jonine D., primary, Tang, Wei, primary, Porter-Gill, Patricia, primary, Chatterjee, Nilanjan, primary, Scott-Johnson, Alexandra, primary, Garcia-Closas, Montserrat, primary, Muchmore, Brian, primary, Baris, Dalsu, primary, Paquin, Ashley, primary, Ylaya, Kris, primary, Schwenn, Molly, primary, Apolo, Andrea B., primary, Karagas, Margaret R., primary, Tarway, McAnthony, primary, Johnson, Alison, primary, Mumy, Adam, primary, Schned, Alan, primary, Guedez, Liliana, primary, Jones, Michael A., primary, Kida, Masatoshi, primary, Hosain, GM Monawar, primary, Malats, Nuria, primary, Kogevinas, Manolis, primary, Tardon, Adonina, primary, Serra, Consol, primary, Carrato, Alfredo, primary, Garcia-Closas, Reina, primary, Lloreta, Josep, primary, Wu, Xifeng, primary, Purdue, Mark, primary, Andriole, Gerald L., primary, Grubb, Robert L., primary, Black, Amanda, primary, Landi, Maria T., primary, Caporaso, Neil E., primary, Vineis, Paolo, primary, Siddiq, Afshan, primary, Bueno-de-Mesquita, H. Bas, primary, Trichopoulos, Dimitrios, primary, Ljungberg, Börje, primary, Severi, Gianluca, primary, Weiderpass, Elisabete, primary, Krogh, Vittorio, primary, Dorronsoro, Miren, primary, Travis, Ruth C., primary, Tjønneland, Anne, primary, Brennan, Paul, primary, Chang-Claude, Jenny, primary, Riboli, Elio, primary, Prescott, Jennifer, primary, Chen, Constance, primary, De Vivo, Immaculata, primary, Govannucci, Edward, primary, Hunter, David, primary, Kraft, Peter, primary, Lindstrom, Sara, primary, Gapstur, Susan M., primary, Jacobs, Eric J., primary, Diver, W. Ryan, primary, Albanes, Demetrius, primary, Weinstein, Stephanie J., primary, Virtamo, Jarmo, primary, Kooperberg, Charles, primary, Hohensee, Chancellor, primary, Rodabough, Rebecca J., primary, Cortessis, Victoria K., primary, Conti, David V., primary, Gago-Dominguez, Manuela, primary, Stern, Mariana C., primary, Pike, Malcolm C., primary, Van Den Berg, David, primary, Yuan, Jian-Min, primary, Haiman, Christopher A., primary, Cussenot, Olivier, primary, Cancel-Tassin, Geraldine, primary, Roupret, Morgan, primary, Comperat, Eva, primary, Porru, Stefano, primary, Carta, Angela, primary, Pavanello, Sofia, primary, Arici, Cecilia, primary, Mastrangelo, Giuseppe, primary, Grossman, H. Barton, primary, Wang, Zhaoming, primary, Deng, Xiang, primary, Chung, Charles C., primary, Hutchinson, Amy, primary, Burdette, Laurie, primary, Wheeler, William, primary, Fraumeni, Joseph, primary, Chanock, Stephen J., primary, Hewitt, Stephen M., primary, Silverman, Debra T., primary, Rothman, Nathaniel, primary, and Prokunina-Olsson, Ludmila, primary

Published
2023
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26. Supplementary Figure 1 from Polymorphisms in DNA Repair Genes, Smoking, and Bladder Cancer Risk: Findings from the International Consortium of Bladder Cancer

Author

Stern, Mariana C., primary, Lin, Jie, primary, Figueroa, Jonine D., primary, Kelsey, Karl T., primary, Kiltie, Anne E., primary, Yuan, Jian-Min, primary, Matullo, Giuseppe, primary, Fletcher, Tony, primary, Benhamou, Simone, primary, Taylor, Jack A., primary, Placidi, Donatella, primary, Zhang, Zuo-Feng, primary, Steineck, Gunnar, primary, Rothman, Nathaniel, primary, Kogevinas, Manolis, primary, Silverman, Debra, primary, Malats, Nuria, primary, Chanock, Stephen, primary, Wu, Xifeng, primary, Karagas, Margaret R., primary, Andrew, Angeline S., primary, Nelson, Heather H., primary, Bishop, D. Timothy, primary, Sak, Sei Chung, primary, Choudhury, Ananya, primary, Barrett, Jennifer H., primary, Elliot, Faye, primary, Corral, Román, primary, Joshi, Amit D., primary, Gago-Dominguez, Manuela, primary, Cortessis, Victoria K., primary, Xiang, Yong-Bing, primary, Gao, Yu-Tang, primary, Vineis, Paolo, primary, Sacerdote, Carlotta, primary, Guarrera, Simonetta, primary, Polidoro, Silvia, primary, Allione, Alessandra, primary, Gurzau, Eugen, primary, Koppova, Kvetoslava, primary, Kumar, Rajiv, primary, Rudnai, Peter, primary, Porru, Stefano, primary, Carta, Angela, primary, Campagna, Marcello, primary, Arici, Cecilia, primary, Park, Sung Shim Lani, primary, and Garcia-Closas, Montserrat, primary

Published
2023
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27. Supplementary Table 5 from The 19q12 Bladder Cancer GWAS Signal: Association with Cyclin E Function and Aggressive Disease

Author

Fu, Yi-Ping, primary, Kohaar, Indu, primary, Moore, Lee E., primary, Lenz, Petra, primary, Figueroa, Jonine D., primary, Tang, Wei, primary, Porter-Gill, Patricia, primary, Chatterjee, Nilanjan, primary, Scott-Johnson, Alexandra, primary, Garcia-Closas, Montserrat, primary, Muchmore, Brian, primary, Baris, Dalsu, primary, Paquin, Ashley, primary, Ylaya, Kris, primary, Schwenn, Molly, primary, Apolo, Andrea B., primary, Karagas, Margaret R., primary, Tarway, McAnthony, primary, Johnson, Alison, primary, Mumy, Adam, primary, Schned, Alan, primary, Guedez, Liliana, primary, Jones, Michael A., primary, Kida, Masatoshi, primary, Hosain, GM Monawar, primary, Malats, Nuria, primary, Kogevinas, Manolis, primary, Tardon, Adonina, primary, Serra, Consol, primary, Carrato, Alfredo, primary, Garcia-Closas, Reina, primary, Lloreta, Josep, primary, Wu, Xifeng, primary, Purdue, Mark, primary, Andriole, Gerald L., primary, Grubb, Robert L., primary, Black, Amanda, primary, Landi, Maria T., primary, Caporaso, Neil E., primary, Vineis, Paolo, primary, Siddiq, Afshan, primary, Bueno-de-Mesquita, H. Bas, primary, Trichopoulos, Dimitrios, primary, Ljungberg, Börje, primary, Severi, Gianluca, primary, Weiderpass, Elisabete, primary, Krogh, Vittorio, primary, Dorronsoro, Miren, primary, Travis, Ruth C., primary, Tjønneland, Anne, primary, Brennan, Paul, primary, Chang-Claude, Jenny, primary, Riboli, Elio, primary, Prescott, Jennifer, primary, Chen, Constance, primary, De Vivo, Immaculata, primary, Govannucci, Edward, primary, Hunter, David, primary, Kraft, Peter, primary, Lindstrom, Sara, primary, Gapstur, Susan M., primary, Jacobs, Eric J., primary, Diver, W. Ryan, primary, Albanes, Demetrius, primary, Weinstein, Stephanie J., primary, Virtamo, Jarmo, primary, Kooperberg, Charles, primary, Hohensee, Chancellor, primary, Rodabough, Rebecca J., primary, Cortessis, Victoria K., primary, Conti, David V., primary, Gago-Dominguez, Manuela, primary, Stern, Mariana C., primary, Pike, Malcolm C., primary, Van Den Berg, David, primary, Yuan, Jian-Min, primary, Haiman, Christopher A., primary, Cussenot, Olivier, primary, Cancel-Tassin, Geraldine, primary, Roupret, Morgan, primary, Comperat, Eva, primary, Porru, Stefano, primary, Carta, Angela, primary, Pavanello, Sofia, primary, Arici, Cecilia, primary, Mastrangelo, Giuseppe, primary, Grossman, H. Barton, primary, Wang, Zhaoming, primary, Deng, Xiang, primary, Chung, Charles C., primary, Hutchinson, Amy, primary, Burdette, Laurie, primary, Wheeler, William, primary, Fraumeni, Joseph, primary, Chanock, Stephen J., primary, Hewitt, Stephen M., primary, Silverman, Debra T., primary, Rothman, Nathaniel, primary, and Prokunina-Olsson, Ludmila, primary

Published
2023
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29. Modeling the Complex Exposure History of Smoking in Predicting Bladder Cancer: A Pooled Analysis of 15 Case–Control Studies

Author

van Osch, Frits H. M., Vlaanderen, Jelle, Jochems, Sylvia H. J., Bosetti, Cristina, Polesel, Jerry, Porru, Stefano, Carta, Angela, Golka, Klaus, Jiang, Xuejuan, Stern, Mariana C., Zhong, Wei-De, Kellen, Eliane, Pohlabeln, Hermann, Tang, Li, Marshall, James, Steineck, Gunnar, Karagas, Margaret R., Johnson, Kenneth C., Zhang, Zuo-Feng, Taylor, Jack A., La Vecchia, Carlo, Bryan, Richard T., van Schooten, Frederik J., Wesselius, Anke, and Zeegers, Maurice P.

Published
2019
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36. SARS-CoV-2 Breakthrough Infections: Incidence and Risk Factors in a Large European Multicentric Cohort of Health Workers

Author

Porru, Stefano, primary, Monaco, Maria Grazia Lourdes, additional, Spiteri, Gianluca, additional, Carta, Angela, additional, Pezzani, Maria Diletta, additional, Lippi, Giuseppe, additional, Gibellini, Davide, additional, Tacconelli, Evelina, additional, Dalla Vecchia, Ilaria, additional, Sala, Emma, additional, Sansone, Emanuele, additional, De Palma, Giuseppe, additional, Bonfanti, Carlo, additional, Lombardo, Massimo, additional, Terlenghi, Luigina, additional, Pira, Enrico, additional, Mansour, Ihab, additional, Coggiola, Maurizio, additional, Ciocan, Catalina, additional, Godono, Alessandro, additional, Tardon, Adonina, additional, Rodriguez-Suarez, Marta-Maria, additional, Fernandez-Tardon, Guillermo, additional, Jimeno-Demuth, Francisco-Jose, additional, Castro-Delgado, Rafael-Vicente, additional, Iglesias Cabo, Tania, additional, Scapellato, Maria Luisa, additional, Liviero, Filippo, additional, Moretto, Angelo, additional, Mason, Paola, additional, Pavanello, Sofia, additional, Volpin, Anna, additional, Vimercati, Luigi, additional, Tafuri, Silvio, additional, De Maria, Luigi, additional, Sponselli, Stefania, additional, Stefanizzi, Pasquale, additional, Caputi, Antonio, additional, Gobba, Fabriziomaria, additional, Modenese, Alberto, additional, Casolari, Loretta, additional, Garavini, Denise, additional, D’Elia, Cristiana, additional, Mariani, Stefania, additional, Filon, Francesca Larese, additional, Cegolon, Luca, additional, Negro, Corrado, additional, Ronchese, Federico, additional, Rui, Francesca, additional, De Michieli, Paola, additional, Murgia, Nicola, additional, Dell’Omo, Marco, additional, Muzi, Giacomo, additional, Fiordi, Tiziana, additional, Gambelunghe, Angela, additional, Folletti, Ilenia, additional, Mates, Dana, additional, Calota, Violeta Claudia, additional, Neamtu, Andra, additional, Perseca, Ovidiu, additional, Staicu, Catalin Alexandru, additional, Voinoiu, Angelica, additional, Fabiánová, Eleonóra, additional, Bérešová, Jana, additional, Adamčáková, Zora Kľocová, additional, Nedela, Roman, additional, Lesňáková, Anna, additional, Holčíková, Jana, additional, Boffetta, Paolo, additional, Abedini, Mahsa, additional, Ditano, Giorgia, additional, Asafo, Shuffield Seyram, additional, Visci, Giovanni, additional, Violante, Francesco Saverio, additional, Zunarelli, Carlotta, additional, and Verlato, Giuseppe, additional

Published
2022
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37. Serological response after SARS-CoV2 vaccination in healthcare workers: a multicenter study

Author

Giovanni, Visci, Carlotta, Zunarelli, Ihab, Mansour, Porru, Stefano, Gi¬useppe De Palma, Xavier, Duval, Monaco, MARIA GRAZIA LOURDES, Spiteri, Gianluca, Carta, Angela, Lippi, Giuseppe, Verlato, Giuseppe, Emanuele, San¬sone, Emma, Sala, Massimo, Lombardo, Mahsa, Abedini, Francesco, Violante, and Paolo, Boffetta

Subjects
Health care workers, COVID-19 Vaccines, SARS-CoV-2, vaccination, immunologic response, antibodies, Health Personnel, Vaccination, COVID-19, Antibodies, Viral, Antibodies, RNA, Humans, RNA, Viral, Female, Viral, Retrospective Studies
Abstract

Characterizing immunological response following COVID-19 vaccination is an important public health issue. The objectives of the present analysis were to investigate the proportion, level and the determinants of humoral response from 21 days to three months after the first dose in vaccinated healthcare workers (HCWs).We abstracted data on level of anti-SARS-CoV-2 Spike antibodies (IgG) and sociodemographic characteristics of 17,257 HCWs from public hospitals and public health authorities from three centers in Northern Italy who underwent COVID-19 vaccination (average 70.6 days after first dose). We fitted center-specific multivariate regression models and combined them using random-effects meta-analyses.A humoral response was elicited in 99.3% of vaccinated HCW. Female sex, young age, and previous COVID-19 infection were predictors of post-vaccination antibody level, and a positive association was also detected with pre-vaccination serology level and with time between pre- and post-vaccination testing, while a decline of antibody level was suggested with time since vaccination.These results stress the importance of analyzing retrospective data collected via occupational health surveillance of HCWs during the COVID-19 epidemic and following vaccination. They need to be confirmed in larger series based on prospectively collected data.

Published
2022

38. Rasch-Validated Italian Scale for Diagnosing Digital Eye Strain: The Computer Vision Syndrome Questionnaire IT©

Author

Universidad de Alicante. Departamento de Óptica, Farmacología y Anatomía, Universidad de Alicante. Departamento de Enfermería Comunitaria, Medicina Preventiva y Salud Pública e Historia de la Ciencia, Universidad de Alicante. Departamento de Enfermería, Cantó Sancho, Natalia, Ronda-Pérez, Elena, Cabrero-García, Julio, Casati, Stefano, Carta, Angela, Porru, Stefano, Seguí-Crespo, Mar, Universidad de Alicante. Departamento de Óptica, Farmacología y Anatomía, Universidad de Alicante. Departamento de Enfermería Comunitaria, Medicina Preventiva y Salud Pública e Historia de la Ciencia, Universidad de Alicante. Departamento de Enfermería, Cantó Sancho, Natalia, Ronda-Pérez, Elena, Cabrero-García, Julio, Casati, Stefano, Carta, Angela, Porru, Stefano, and Seguí-Crespo, Mar

Abstract

The use of digital devices affects eye health; this can influence the performance of workers. To assess this impact, validated patient-reported outcome questionnaires are needed. The purpose of this study was to validate the psychometric properties of the Italian version of the Computer Vision Syndrome Questionnaire (CVS-Q©) using Rasch analysis. Two hundred and forty-one Italian workers completed an ad hoc questionnaire on anamnesis and exposure to digital devices, and the Italian version of the CVS-Q©. Subsequently, a battery involving three clinical ocular surface and tear tests was performed. The reliability and validity of the scale was assessed using the Andrich Rating Scale Model, and the prevalence of computer vision syndrome (CVS) was calculated. A good fit of both items and persons to the predictions of the Rasch model was observed, with acceptable reliability, unidimensionality, and no or minimal severe differences as a function of gender or age; moreover, good test–retest repeatability, adequate values of sensitivity, reliability, and area under the curve, and adequate construct validity based on clinical tests were obtained. Workers with a questionnaire score ≥ 7 were found to present with CVS. The prevalence of CVS was 76.6%. The CVS-Q IT© is a valid and reliable scale to assess CVS in Italian workers who use digital devices.

Published
2022

41. Determinants of anti-S immune response at 6 months after COVID-19 vaccination in a multicentric European cohort of healthcare workers - ORCHESTRA project

Author

Collatuzzo, Giulia, Visci, Giovanni, Violante, Francesco S, Porru, Stefano, Spiteri, Gianluca, Monaco, Maria Grazia Lourdes, Larese Fillon, Francesca, Negro, Corrado, Janke, Christian, Castelletti, Noemi, De Palma, Giuseppe, Sansone, Emanuele, Mates, Dana, Teodorescu, Silvia, Fabiánová, Eleonóra, Bérešová, Jana, Vimercati, Luigi, Tafuri, Silvio, Abedini, Mahsa, Ditano, Giorgia, Asafo, Shuffield S, Boffetta, Paolo, Zunarelli, Carlotta, Bonfiglioli, Roberta, Carta, Angela, Verlato, Giuseppe, Lippi, Giuseppe, Gibellini, Davide, Pezzani, Maria Diletta, Torroni, Lorena, Hoelscher, Michael, Wieser, Andreas, Reinkemeyer, Christina, Plank, Michael, Noreña, Ivan, Rubio-Acero, Raquel, Winter, Simon, Leustean, Mihaela, Perseca, Ovidiu, Ipate, Madalina, Agripina, Rascu, Strhársky, Jozef, Hellebrandt, Petra, Križanová, Daniela, Mrázová, Marianna, De Maria, Luigi, Sponselli, Stefania, Stefanizzi, Pasquale, Caputi, Antonio, Collatuzzo G., Visci G., Violante F.S., Porru S., Spiteri G., Monaco M.G.L., Larese Fillon F., Negro C., Janke C., Castelletti N., De Palma G., Sansone E., Mates D., Teodorescu S., Fabianova E., Beresova J., Vimercati L., Tafuri S., Abedini M., Ditano G., Asafo S.S., and Boffetta P.

Subjects
COVID-19 Vaccines, vaccine, COVID – 19, serology, health care workers (HCW), immune response, Health Personnel, Immunology, COVID – 19, Vaccination, health care workers (HCW), Immunity, immune response, serology, vaccine, Infant, COVID-19, Antibodies, Viral, Antibodies, Immunoglobulin G, Immunology and Allergy, Humans, Female, Viral, Human
Abstract

BackgroundThe duration of immune response to COVID-19 vaccination is of major interest. Our aim was to analyze the determinants of anti-SARS-CoV-2 IgG titer at 6 months after 2-dose vaccination in an international cohort of vaccinated healthcare workers (HCWs).MethodsWe analyzed data on levels of anti-SARS-CoV-2 Spike antibodies and sociodemographic and clinical characteristics of 6,327 vaccinated HCWs from 8 centers from Germany, Italy, Romania and Slovakia. Time between 1st dose and serology ranged 150-210 days. Serological levels were log-transformed to account for the skewness of the distribution and normalized by dividing them by center-specific standard errors, obtaining standardized values. We fitted center-specific multivariate regression models to estimate the cohort-specific relative risks (RR) of an increase of 1 standard deviation of log antibody level and corresponding 95% confidence interval (CI), and finally combined them in random-effects meta-analyses.ResultsA 6-month serological response was detected in 99.6% of HCWs. Female sex (RR 1.10, 95%CI 1.00-1.21), past infection (RR 2.26, 95%CI 1.73-2.95) and two vaccine doses (RR 1.50, 95%CI 1.22-1.84) predicted higher IgG titer, contrary to interval since last dose (RR for 10-day increase 0.94, 95%CI 0.91-0.97) and age (RR for 10-year increase 0.87, 95%CI 0.83-0.92). M-RNA-based vaccines (pConclusionsFemale gender, young age, past infection, two vaccine doses, and m-RNA and heterologous vaccination predicted higher antibody level at 6 months. These results corroborate previous findings and offer valuable data for comparison with trends observed with longer follow-ups.

Published
2022

49. SARS-CoV-2 Infection in Health Workers: Analysis from Verona SIEROEPID Study during the Pre-Vaccination Era

Author

Porru, Stefano, primary, Monaco, Maria Grazia Lourdes, additional, Carta, Angela, additional, Spiteri, Gianluca, additional, Parpaiola, Marco, additional, Battaggia, Andrea, additional, Galligioni, Giulia, additional, Ferrazzi, Beatrice, additional, Lo Cascio, Giuliana, additional, Gibellini, Davide, additional, Peretti, Angelo, additional, Brutti, Martina, additional, Tardivo, Stefano, additional, Ghirlanda, Giovanna, additional, Verlato, Giuseppe, additional, Gaino, Stefania, additional, Peserico, Denise, additional, Bassi, Antonella, additional, and Lippi, Giuseppe, additional

Published
2021
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