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1. Do patients’ and referral centers’ characteristics influence multiple sclerosis phenotypes? Results from the Italian multiple sclerosis and related disorders register

Author

Bergamaschi, Roberto, Beghi, Ettore, Bosetti, Cristina, Ponzio, Michela, Santucci, Claudia, Lepore, Vito, Mosconi, Paola, Aguglia, U., Amato, M. P., Ancona, A. L., Ardito, B., Avolio, C., Balgera, R., Banfi, P., Barcella, V., Barone, P., Bellantonio, P., Berardinelli, A., Bergamaschi, R., Bertora, P., Bianchi, M., Bramanti, P., Morra, V. Brescia, Brichetto, G., Brioschi, A. M., Buccafusca, M., Bucello, S., Busillo, V., Calchetti, B., Cantello, R., Capobianco, M., Capone, F., Capone, L., Cargnelutti, D., Carrozzi, M., Cartechini, E., Cavaletti, G., Cavalla, P., Celani, M. G., Clerici, R., Clerico, M., Cocco, E., Confalonieri, P., Coniglio, M. G., Conte, A., Corea, F., Cottone, S., Crociani, P., D’Andrea, F., Danni, M. C., De Luca, G., de Pascalis, D., De Riz, M., De Robertis, F., De Rosa, G., De Stefano, N., Corte, M. Della, Di Sapio, A., Docimo, R., Falcini, M., Falcone, N., Fermi, S., Ferraro, E., Ferrò, M. T., Fortunato, M., Foschi, M., Gajofatto, A., Gallo, A., Gallo, P., Gatto, M., Gazzola, P., Giordano, A., Granella, F., Grasso, M. F., Grasso, M. G., Grimaldi, L. M. E., Iaffaldano, P., Imperiale, D., Inglese, M., Iodice, R., Leva, S., Luezzi, V., Lugaresi, A., Lus, G., Maimone, D., Mancinelli, L., Maniscalco, G. T., Marfia, G. A., Marini, B., Marson, A., Mascoli, N., Massacesi, L., Melani, F., Merello, M., Meucci, G., Mirabella, M., Montepietra, S., Nasuelli, D., Nicolao, P., Passantino, F., Patti, F., Peresson, M., Pesci, I., Piantadosi, C., Piras, M. L., Pizzorno, M., Plewnia, K., Pozzilli, C., Protti, A., Quatrale, R., Realmuto, S., Ribizzi, G., Rinalduzzi, S., Rini, A., Romano, S., Romeo, M., Ronzoni, M., Rossi, P., Rovaris, M., Salemi, G., Santangelo, G., Santangelo, M., Santuccio, G., Sarchielli, P., Sinisi, L., Sola, P., Solaro, C., Spitaleri, D., Strumia, S., Tassinari, T., Tonietti, S., Tortorella, C., Totaro, R., Tozzo, A., Trivelli, G., Ulivelli, M., Valentino, P., Venturi, S., Vianello, M., Zaffaroni, M., Zarbo, R., Trojano, Maria, Battaglia, Mario Alberto, Capobianco, Marco, Pugliatti, Maura, Ulivelli, Monica, Mosconi, Paola, Gasperini, Claudio, Patti, Francesco, Amato, Maria Pia, Bergamaschi, Roberto, and Comi, Giancarlo

Published
2022
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2. Early diagnosis and Early Start Denver Model intervention in autism spectrum disorders delivered in an Italian Public Health System service

Author

Devescovi R, Monasta L, Mancini A, Bin M, Vellante V, Carrozzi M, and Colombi C

Subjects
Early diagnosis, Early intervention, Autism Spectrum Disorder, Early Start Denver Model, Public Health System Service, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Raffaella Devescovi,1 Lorenzo Monasta,2 Alice Mancini,3 Maura Bin,1 Valerio Vellante,1 Marco Carrozzi,1 Costanza Colombi4 1Division of Child Neurology and Psychiatry, 2Clinical Epidemiology and Public Health Research Unit, Institute for Maternal and Child Health – IRCCS “Burlo Garofolo”, Trieste, 3Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy; 4Department of Psychiatry, University of Michigan Health System, Ann Arbor, MI, USA Background: Early diagnosis combined with an early intervention program, such as the Early Start Denver Model (ESDM), can positively influence the early natural history of autism spectrum disorders. This study evaluated the effectiveness of an early ESDM-inspired intervention, in a small group of toddlers, delivered at low intensity by the Italian Public Health System.Methods: Twenty-one toddlers at risk for autism spectrum disorders, aged 20–36 months, received 3 hours/wk of one-to-one ESDM-inspired intervention by trained therapists, combined with parents’ and teachers’ active engagement in ecological implementation of treatment. The mean duration of treatment was 15 months. Cognitive and communication skills, as well as severity of autism symptoms, were assessed by using standardized measures at pre-intervention (Time 0 [T0]; mean age =27 months) and post-intervention (Time 1 [T1]; mean age =42 months).Results: Children made statistically significant improvements in the language and cognitive domains, as demonstrated by a series of nonparametric Wilcoxon tests for paired data. Regarding severity of autism symptoms, younger age at diagnosis was positively associated with greater improvement at post-assessment.Conclusion: Our results are consistent with the literature that underlines the importance of early diagnosis and early intervention, since prompt diagnosis can reduce the severity of autism symptoms and improve cognitive and language skills in younger children. Particularly in toddlers, it seems that an intervention model based on the ESDM principles, involving the active engagement of parents and nursery school teachers, may be effective even when the individual treatment is delivered at low intensity. Furthermore, our study supports the adaptation and the positive impact of the ESDM entirely sustained by the Italian Public Health System. Keywords: early diagnosis, early intervention, autism spectrum disorder, Early Start Denver Model, Public Health System service

Published
2016

4. Do patients' and referral centers' characteristics influence multiple sclerosis phenotypes? Results from the Italian multiple sclerosis and related disorders register

Author

Bergamaschi, R, Beghi, E, Bosetti, C, Ponzio, M, Santucci, C, Lepore, V, Mosconi, P, Aguglia, U, Amato, M, Ancona, A, Ardito, B, Avolio, C, Balgera, R, Banfi, P, Barcella, V, Barone, P, Bellantonio, P, Berardinelli, A, Bertora, P, Bianchi, M, Bramanti, P, Morra, V, Brichetto, G, Brioschi, A, Buccafusca, M, Bucello, S, Busillo, V, Calchetti, B, Cantello, R, Capobianco, M, Capone, F, Capone, L, Cargnelutti, D, Carrozzi, M, Cartechini, E, Cavaletti, G, Cavalla, P, Celani, M, Clerici, R, Clerico, M, Cocco, E, Confalonieri, P, Coniglio, M, Conte, A, Corea, F, Cottone, S, Crociani, P, D'Andrea, F, Danni, M, De Luca, G, de Pascalis, D, De Riz, M, De Robertis, F, De Rosa, G, De Stefano, N, Corte, M, Di Sapio, A, Docimo, R, Falcini, M, Falcone, N, Fermi, S, Ferraro, E, Ferrò, M, Fortunato, M, Foschi, M, Gajofatto, A, Gallo, A, Gallo, P, Gatto, M, Gazzola, P, Giordano, A, Granella, F, Grasso, M, Grimaldi, L, Iaffaldano, P, Imperiale, D, Inglese, M, Iodice, R, Leva, S, Luezzi, V, Lugaresi, A, Lus, G, Maimone, D, Mancinelli, L, Maniscalco, G, Marfia, G, Marini, B, Marson, A, Mascoli, N, Massacesi, L, Melani, F, Merello, M, Meucci, G, Mirabella, M, Montepietra, S, Nasuelli, D, Nicolao, P, Passantino, F, Patti, F, Peresson, M, Pesci, I, Piantadosi, C, Piras, M, Pizzorno, M, Plewnia, K, Pozzilli, C, Protti, A, Quatrale, R, Realmuto, S, Ribizzi, G, Rinalduzzi, S, Rini, A, Romano, S, Romeo, M, Ronzoni, M, Rossi, P, Rovaris, M, Salemi, G, Santangelo, G, Santangelo, M, Santuccio, G, Sarchielli, P, Sinisi, L, Sola, P, Solaro, C, Spitaleri, D, Strumia, S, Tassinari, T, Tonietti, S, Tortorella, C, Totaro, R, Tozzo, A, Trivelli, G, Ulivelli, M, Valentino, P, Venturi, S, Vianello, M, Zaffaroni, M, Zarbo, R, Trojano, M, Battaglia, M, Pugliatti, M, Gasperini, C, Comi, G, Bergamaschi, Roberto, Beghi, Ettore, Bosetti, Cristina, Ponzio, Michela, Santucci, Claudia, Lepore, Vito, Mosconi, Paola, Amato, M P, Ancona, A L, Morra, V Brescia, Brioschi, A M, Celani, M G, Coniglio, M G, Danni, M C, Corte, M Della, Ferrò, M T, Grasso, M F, Grasso, M G, Grimaldi, L M E, Maniscalco, G T, Marfia, G A, Piras, M L, Trojano, Maria, Battaglia, Mario Alberto, Capobianco, Marco, Pugliatti, Maura, Ulivelli, Monica, Gasperini, Claudio, Patti, Francesco, Amato, Maria Pia, Comi, Giancarlo, Bergamaschi, R, Beghi, E, Bosetti, C, Ponzio, M, Santucci, C, Lepore, V, Mosconi, P, Aguglia, U, Amato, M, Ancona, A, Ardito, B, Avolio, C, Balgera, R, Banfi, P, Barcella, V, Barone, P, Bellantonio, P, Berardinelli, A, Bertora, P, Bianchi, M, Bramanti, P, Morra, V, Brichetto, G, Brioschi, A, Buccafusca, M, Bucello, S, Busillo, V, Calchetti, B, Cantello, R, Capobianco, M, Capone, F, Capone, L, Cargnelutti, D, Carrozzi, M, Cartechini, E, Cavaletti, G, Cavalla, P, Celani, M, Clerici, R, Clerico, M, Cocco, E, Confalonieri, P, Coniglio, M, Conte, A, Corea, F, Cottone, S, Crociani, P, D'Andrea, F, Danni, M, De Luca, G, de Pascalis, D, De Riz, M, De Robertis, F, De Rosa, G, De Stefano, N, Corte, M, Di Sapio, A, Docimo, R, Falcini, M, Falcone, N, Fermi, S, Ferraro, E, Ferrò, M, Fortunato, M, Foschi, M, Gajofatto, A, Gallo, A, Gallo, P, Gatto, M, Gazzola, P, Giordano, A, Granella, F, Grasso, M, Grimaldi, L, Iaffaldano, P, Imperiale, D, Inglese, M, Iodice, R, Leva, S, Luezzi, V, Lugaresi, A, Lus, G, Maimone, D, Mancinelli, L, Maniscalco, G, Marfia, G, Marini, B, Marson, A, Mascoli, N, Massacesi, L, Melani, F, Merello, M, Meucci, G, Mirabella, M, Montepietra, S, Nasuelli, D, Nicolao, P, Passantino, F, Patti, F, Peresson, M, Pesci, I, Piantadosi, C, Piras, M, Pizzorno, M, Plewnia, K, Pozzilli, C, Protti, A, Quatrale, R, Realmuto, S, Ribizzi, G, Rinalduzzi, S, Rini, A, Romano, S, Romeo, M, Ronzoni, M, Rossi, P, Rovaris, M, Salemi, G, Santangelo, G, Santangelo, M, Santuccio, G, Sarchielli, P, Sinisi, L, Sola, P, Solaro, C, Spitaleri, D, Strumia, S, Tassinari, T, Tonietti, S, Tortorella, C, Totaro, R, Tozzo, A, Trivelli, G, Ulivelli, M, Valentino, P, Venturi, S, Vianello, M, Zaffaroni, M, Zarbo, R, Trojano, M, Battaglia, M, Pugliatti, M, Gasperini, C, Comi, G, Bergamaschi, Roberto, Beghi, Ettore, Bosetti, Cristina, Ponzio, Michela, Santucci, Claudia, Lepore, Vito, Mosconi, Paola, Amato, M P, Ancona, A L, Morra, V Brescia, Brioschi, A M, Celani, M G, Coniglio, M G, Danni, M C, Corte, M Della, Ferrò, M T, Grasso, M F, Grasso, M G, Grimaldi, L M E, Maniscalco, G T, Marfia, G A, Piras, M L, Trojano, Maria, Battaglia, Mario Alberto, Capobianco, Marco, Pugliatti, Maura, Ulivelli, Monica, Gasperini, Claudio, Patti, Francesco, Amato, Maria Pia, and Comi, Giancarlo

Abstract

Background: Multiple sclerosis (MS) is characterized by phenotypical heterogeneity, partly resulting from demographic and environmental risk factors. Socio-economic factors and the characteristics of local MS facilities might also play a part. Methods: This study included patients with a confirmed MS diagnosis enrolled in the Italian MS and Related Disorders Register in 2000–2021. Patients at first visit were classified as having a clinically isolated syndrome (CIS), relapsing–remitting (RR), primary progressive (PP), progressive-relapsing (PR), or secondary progressive MS (SP). Demographic and clinical characteristics were analyzed, with centers’ characteristics, geographic macro-areas, and Deprivation Index. We computed the odds ratios (OR) for CIS, PP/PR, and SP phenotypes, compared to the RR, using multivariate, multinomial, mixed effects logistic regression models. Results: In all 35,243 patients from 106 centers were included. The OR of presenting more advanced MS phenotypes than the RR phenotype at first visit significantly diminished in relation to calendar period. Females were at a significantly lower risk of a PP/PR or SP phenotype. Older age was associated with CIS, PP/PR, and SP. The risk of a longer interval between disease onset and first visit was lower for the CIS phenotype, but higher for PP/PR and SP. The probability of SP at first visit was greater in the South of Italy. Discussion: Differences in the phenotype of MS patients first seen in Italian centers can be only partly explained by differences in the centers’ characteristics. The demographic and socio-economic characteristics of MS patients seem to be the main determinants of the phenotypes at first referral.

Published
2022

12. Thalidomide-induced peripheral neuropathy in children with inflammatory bowel disease

Author

Bramuzzo, M., Stocco, G., Montico, M., Arrigo, S., Calvi, A., Lanteri, P., Costa, S., Pellegrino, S., Magazzù, G., Berp, J., Ghione, S., Lionetti, P., Zuin, G., Fontana, M., Di Chio, T., Maggiore, Giuseppe, Lazzerini, M., Lucafò, M., Udina, C., Pellegrin, Mc, Chicco, A., Carrozzi, M., Decorti, G., Ventura, A., and Martellossi, S.

Subjects
NO
Published
2017

14. Attention-deficit/hyperactivity disorder drugs and growth: an Italian prospective observational study

Author

Germinario, Ea, Arcieri, R, Bonati, M, Zuddas, A, Masi, G, Vella, S, Chiarotti, F, Panei, P, Italian ADHD Regional Reference Centers, Bobba, B, Veneselli, EDVIGE MARIA, Baldizzone, Mj, De Nobili, G, Marcelli, M, Torrioli, Mg, Vicari, S, Bartolomeo, S, Curatolo, P, Fabrizi, A, Donfrancesco, R, Parisi, R, Suglia, D, Nicoletta, M, Stagi, P, Murru, F, Tullini, A, Chiodo, S, Pirisi, A, Morbin, E, Milantoni, L, Bernardina, Bd, Maschietto, D, Mambelli, C, Condini, A, Brighenti, M, Miottello, P, Tombolato, R, Rizzo, L, Gemma, A, Musumeci, S, Vanadia, F, Costanza, G, Ragusa, D, Calamoneri, F, Mazzone, D, Giaccherini, F, Carrozzi, M, Cremaschi, S, Ottolini, A, Arisi, D, Tiberti, A, Terragni, Ml, Morosini, P, Meraviglia, C, Lenti, C, Pezzani, M, Balottin, U, Piccinelli, P, Chiarenza, G, Brunati, E, Montrasio, V, Molteni, M, Rinaldi, F, Rossi, G, Segala, R, Guccione, F, Bailo, P, Besana, D, Bassi, B, Rolando, M, Jarre, L, Ragazzo, F, Tondi, M, Casara, G, Arcangeli, D, Stermann, I, Giannelli, C, Voltolin, G, Legge, Mp, Sechi, E, Gennaro, E, Campolo, G, La Vitola, A, Mingolla, A, Spina, A, Margari, L, Massagli, A, Bravaccio, C, Granato, R, Grimaldi, G, Mazzotta, G, Cioni, G, Pincherle, M, Cesare, C, Stoppioni, V, Rosolino, T., Bobba, B, Veneselli, E, Baldizzone, Mj, De Nobili, G, Marcelli, M, Torrioli, Mg, Vicari, S, Bartolomeo, S, Curatolo, P, Fabrizi, A, Donfrancesco, R, Parisi, R, Suglia, D, Nicoletta, M, Stagi, P, Murru, F, Tullini, A, Chiodo, S, Pirisi, A, Morbin, E, Milantoni, L, Bernardina, Bd, Maschietto, D, Mambelli, C, Condini, A, Brighenti, M, Miottello, P, Tombolato, R, Rizzo, L, Gemma, A, Musumeci, S, Vanadia, F, Costanza, G, Ragusa, D, Calamoneri, F, Mazzone, D, Giaccherini, F, Carrozzi, M, Cremaschi, S, Ottolini, A, Arisi, D, Tiberti, A, Terragni, Ml, Morosini, P, Meraviglia, C, Lenti, C, Pezzani, M, Balottin, U, Piccinelli, P, Chiarenza, G, Brunati, E, Montrasio, V, Molteni, M, Rinaldi, F, Rossi, G, Segala, R, Guccione, F, Bailo, P, Besana, D, Bassi, B, Rolando, M, Jarre, L, Ragazzo, F, Zuddas, A, Tondi, M, Casara, G, Arcangeli, D, Stermann, I, Giannelli, C, Voltolin, G, Legge, Mp, Sechi, E, Gennaro, E, Campolo, G, La Vitola, A, Mingolla, A, Spina, A, Margari, L, Massagli, A, Bravaccio, C, Granato, R, Grimaldi, G, Mazzotta, G, Masi, G, Cioni, G, Pincherle, M, Cesare, C, Stoppioni, V, and Rosolino, T.

Subjects
Male, Pediatrics, medicine.medical_specialty, Percentile, Adolescent, Body weight, Atomoxetine Hydrochloride, Child Development, mental disorders, medicine, Attention deficit hyperactivity disorder, Humans, Pharmacology (medical), Prospective Studies, Registries, Prospective cohort study, Child, Adrenergic Uptake Inhibitors, Propylamines, Methylphenidate, Atomoxetine, Body Weight, Original Articles, Adolescent Development, medicine.disease, Body Height, Surgery, Psychiatry and Mental health, Italy, Attention Deficit Disorder with Hyperactivity, Pediatrics, Perinatology and Child Health, Observational study, Central Nervous System Stimulants, Female, Psychology, human activities, medicine.drug, Atomoxetine hydrochloride
Abstract

This study was conducted to assess the long-term effect of methylphenidate (MPH) or atomoxetine (ATX) on growth in attention-deficit/hyperactivity disorder (ADHD) drug-naïve children.The study was an observational, post-marketing, fourth phase study.Data on height and weight were collected at baseline and every 6 months up to 24 months.Both ATX and MPH lead to decreased height gain (assessed by means of z-scores); the effect was significantly higher for ATX than for MPH. At any time, height z-score decrease in the ATX group was higher than the corresponding decrease observed in the MPH group, but the difference was significantly relevant only during the first year of treatment. An increment of average weight was observed both in patients treated with MPH and in those treated with ATX. However, using Tanner's percentile, a subset of patients showed a degree of growth lower than expected. This negative effect was significantly higher for ATX than for MPH.We conclude that ADHD drugs show a negative effect on linear growth in children in middle term. Such effect appears more evident for ATX than for MPH.

Published
2013

15. Il referente per la dislessia. La situazione nella Regione Friuli Venezia Giulia

Author

Melon C., Lonciari I., Colcergnan E., Carrozzi M., BORTOLOTTI, ELENA, Melon, C., Bortolotti, Elena, Lonciari, I., Colcergnan, E., and Carrozzi, M.

Subjects
dislessia, vissuti degli insegnanti, insegnante referente, sportello DSA, formazione
Abstract

Il Ministero dell’Istruzione, dell’Università e della Ricerca, durante l’anno scolastico 2005-2006, ha incaricato l’Associazione Italiana Dislessia di realizzare un programma di formazione rivolto agli insegnanti, esteso a tutto il territorio nazionale (progetto «Azione 7»). L’obiettivo era creare la figura dell’insegnante referente, che potesse fornire una prima consulenza in tema di Disturbi Specifici dell’Apprendimento (DSA) già all’interno della scuola. Nell’ambito di un progetto di ricerca della SCO di Neuropsichiatria Infantile e Neurologia Pediatrica dell’IRCCS «Burlo Garofolo» di Trieste,1 che perseguiva anche l’obiettivo di fornire agli insegnanti gli strumenti per elaborare un intervento didattico-educativo precoce per gli alunni con difficoltà scolastiche, abbiamo quindi voluto verificare, a distanza di quattro anni, lo stato di realizzazione del progetto «Azione 7» e come il ruolo dell’insegnante referente venga vissuto ed espletato dagli insegnanti della Regione Friuli Venezia Giulia. La rilevazione è stata eseguita per mezzo di un questionario creato ad hoc e rivolto specificamente agli insegnanti referenti per valutare il tipo di attività svolta dall’insegnante referente nel mondo scolastico, la percezione nei confronti del proprio ruolo e i bisogni formativi ritenuti funzionali ad esso. I risultati della rilevazione documentano l’interesse degli insegnanti a sperimentarsi in questo nuovo ruolo e la richiesta di formazione e supervisione su casi specifici. Vengono quindi discusse alcune modalità operative che prevedono non solo la sensibilizzazione della dirigenza scolastica ma anche la costituzione di una rete tra scuola e strutture sanitarie, al fine di sostenere i referenti nell’attività consulenziale sui DSA.

Published
2012

16. Research on computer based cognitive assessment and educational training: effect of early intervention

Author

MELON C, FLAUGNACCO E, LONCIARI I, GIANGIACOMO G. CARROZZI M., BORTOLOTTI, ELENA, ZANON, FRANCESCA, ICERI, Melon, C, Flaugnacco, E, Bortolotti, Elena, Lonciari, I, Zanon, Francesca, and Giangiacomo, G. CARROZZI M.

Subjects
early intervention, assessment
Abstract

Today researchers agree that there is no clear demarcation between reading and pre-reading skills There are cognitive factors that affect the development of literacy and these interact with environmental factors (one of which is the teacher’s approach) and researchers are interested in assessing them. There are many conventional psychological tests, but in recent years researchers have begun to explore the potential of computer-based assessments as tools for teachers and other professionals. An innovative system is Cops (Cognitive Profiling System), developed in the UK by Singleton (2000). This is a computerised assessment system for children aged 4 to 8 years that has proven scientific validity for the early identification of dyslexia, and can help teachers identify many other cognitive difficulties that can interfere with children's learning. It comprises tests of fundamental cognitive skills that underpin learning. Results, in the form of graphical profiles and individual response records, clearly show children's strengths and weaknesses in comparison with national norms. Thus, potential problems can be spotted at an early stage and appropriate teaching strategies can be offered to overcome difficulties and prevent failure. The aim of this work is to identify the children at risk for the learning difficulties. In particular, we are interested in exploring the effect of an implemented training to minimise the chances of failure and maximise success, at least for the abilities considered and analysed by Cops. In this study report data that prove the effectiveness of early interventions based upon the systematic development of phonological awareness and memory skills. There is also a hypothesis to transfer the training to a computerised program and advantages and disadvantages involved will be discussed.

Published
2009

19. Preface

Author

Giacomello, Alessandro, Peters, G. J., Eriksson, Staffan, De Abreu, Ronney, Kristensen, T., Munch-Petersen, B., Vincenzetti, S., Cambi, A., Neuhard, J., Garattini, E., Vita, A., Oka, J., Matsumoto, A., Hosokawa, Y., Inoue, S., Allegrini, S., Johnson, R. B., Fiol, C. J., Eriksson, S., Fabianowska-Majewska, K., Wasiak, T., Duley, J., Simmonds, A., Bretner, M., Felczak, K., Poznański, J., Dzik, J. M., Golos, B., Jarmuła, A., Rode, W., Kulikowski, T., Codacci-Pisanelli, G., Pinedo, H. M., Noordhuis, P., van Groeningen, C. J., van der Wilt, C. L., Franchi, F., Hatse, S., Balzarini, J., De Clercq, E., Marinello, E., Rosi, F., Dispensa, E., Mangiavacchi, P., Riario-Sforza, G., Agostinho, A. B., Smolenski, R. T., Müller, Mathias M., Roch-Ramel, F., Guisan, B., Diezi, J., Tavenier, M., Skladanowski, A. C., de Abreu, R. A., de Jong, J. W., Åmellem, Øystein, Löffler, Monika, Pettersen, Erik O., Boulieu, R., Lenoir, A., Bertocchi, M., Mornex, J. F., Makarewicz, W., Spychala J., Mitchell B. S., Barankiewcz J., Góra-Tybor, Joanna, Robak, Tadeusz, Spasokukotskaja T., Sasvári-Székely M., Piróth Zs., Kazimierczuk Z., Staub M., Keuzenkamp-Jansen, C W, De Abreu, R A, Bökkerink, J P M, Trijbels, J M F, Eriksson S., Warzocha, K., Krykowski, E., Góra-Tybor, J., Fronczak, A., Robak, T., Minelli, A., Moroni, M., Monacelli, N., Mezzasoma, I., Amici, A., Emanuelli, M., Raffaelli, N., Ruggieri, S., Magni, G., Carta, M. C., Mattana, A., Poddie, F., Sgarrella, F., Tozzi, M. G., Veerman, G., Ruiz van Haperen, V. W. T., van Moorsel, C. J. A., Pesi, R., Baiocchi, C., Camici, M., Ipata, P. L., Kozłowska, M., Świerczyński, J., Smoleński, R. T., Jastorff, B., Messina, E., Savini, F., Procopio, A., Giacomello, A., Wielgus-Kutrowska, B., Kulikowska, E., Wierzchowski, J., Bzowska, A., Shugar, D., Fairbanks, Lynette D, Ruckemann, Katarzyna, Simmonds, H Anne, Kaletha, K., Szymańska, G., Thebault, M., Raffin, J. P., Le Gal, Y., Griesmacher, Andrea, De Abreu, Ronney A., Zych, M., Ruckemann, K., Jagodzinski, P., Kochan, Z., Stolk, J., Boerbooms, A., De Abreu, R., de Koning, D., van de Putte, L., Fiorini, M., Bazzichi, L., Bertolini, G., Martini, C., Ciompi, M. L., Lucacchini, A., Pizzichini, M., Terzuoli, L., Arezzini, L., Fe, L., Pagani, R., Miscetti, P., Allegrucci, C., Sebesta, I., Duley, J. A., Simmonds, H. A., Gross, M., Salerno, C., Stone, T. W., Van den Berghe, G., Valik, Dalibor, Jones, James D., Guerranti, R., Fè, L., Sforza, G. Riario, Knecht, Wolfgang, Grein, Klaus, Lodi, R., Iotti, S., Barbiroli, B., Bonin, B., Chantin, C., Bory, C., Micheli, V., Jacomelli, G., Morozzi, G., Fioravanti, A., Marcolongo, R., Pompucci, G., Peters G J, Noordhuis P, Komissarov A, Holwerda U, Kok R M, Van Laar J A M, Van der Wilt C L, Van Groeningen C J, Pinedo H M, Perrett, David, Jacobsson, Bengt, Sisto A., Iezzi A., Di Carlo M., Pizzigallo E., Akhondzadeh, S., MacGregor, D. G., Ogilvy, H. V., Zoref-Shani, E., Brosh, S., Sidi, Y., Bromberg, Y., Sperling, O., van Gennip, A. H., Abeling, N. G. G. M., Stroomer, A. E. M., van Lenthe, H., Bakker, H. D., van Kuilenburg, A. B. P., Connolly, G. P., Abbott, N. J., Lilling, G., Gozes, I., Vreken, P., Meinsma, R., de Ahreu, R. A., Diasio, R. B., Albin, N., Johnson, M. R., Shahinian, H., Wang, K., Gathof, B. S., Rocchigiani, M., Puig, J. G., Mateos, F., Sestini, S., Krijt, J., Shin, Y., Gresser, U., Costa, A., Maximova, N., Andolina, M., Paci, M., Carrozzi, M., Osbich, A., Durighello, M., Cavalli, F., Geatti, O., Zammarchi, E., Morgan, Gareth, Webster, A. D. B., Slavin, S., Naparstek, E., Nagler, A., Acker, M., Cividalli, G., Kapellushnik, Y., Varadi, G., Ben-Yoseph, R., Or, R., Parfenov, V. V., Ignatenko, M. A., Amchenkova, A. M., Narovlyansky, A. N., Spoto, G., Mastropasqua, L., Gizzi, F., Arduini, A., Del Gallo, P., Ciancaglini, M., Gallenga, P. E., Šebesta, I., Zeman, J., Crifò, C., Di Vito, M., Lomonte, A., Gerber, G., Carlucci, F., Tabucchi, A., Vannoni P., Di Pietro M. C., Vincent, M. F., Bontemps, F., Boer, P., Rötzer, E., Ehrmann, D., Empl, W., Bride, M. B. Mc, Ogg, C. S., Cameron, J. S., Moro, F., Rigden, S., Rees, L., Hoff, W. Van't, Raman, V., Palmieri, P., Mastropierro, G., Albertazzi, A., Rucci, C., Darlington, L. G., Cotton, S. R., de Gorter, J. J., Lawrence, E. S., Petrie, A., Sarsam, R. P., Semple, M. J., Warburton, E. A., Quaratino, C. P., Talone, L., Di Sciascio, N., Hrebíček, M. H., Poupětová, H., Ledvinová, J., Elleder, M., Vondrák, K., Rees, P. C., Wonke, B., Thein, S. L., Clegg, J. B., Marlewski, M., Pennelli, A., Di Marzio, M., Angelini, G., Sabatino, G., de Koning, P., Kerstens, P., de Graaf, R., Hayek, G., and Cardona, F.

Published
1995
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20. Analysis of sleep stage characteristics in full-term newborn by means of spectral and fractal parameters

Author

Carrozzi, M., Accardo, Agostino, Bouquet, F., Carrozzi, M., Accardo, Agostino, and Bouquet, F.

Subjects
full-term newborn, fractal analysi, zero crossing, EEG, fractal analysis, Sleep, spectral analysis
Abstract

Study Objectives: In this work, we studied the behavior of the fractal dimension during each of the neonatal electroencephalogram (EEG) sleep phases and during the awake state, comparing the results with those of the classical spectral parameters and with zero crossing values. Design: Fractal dimension, zero crossing, and spectral parameters of the EEG bands were determined for each 2-second frame of the EEG sleep-time series. Eight channels of each EEG recording were examined. Participants: Twenty healthy full-term newborns (10 boys and 10 girls) with normal psychomotor development evaluated at 24 and 36 months of age, were chosen to participate in this study. Measurements and Results: Fractal analysis showed that where rhythmic and regular activity are present, as during quiet sleep, the fractal dimension is low and rises when bioelectric activity is more variable and complex, reaching its maximum value during wakefulness. The discriminative value of this parameter was similar to ...

Published
2004

22. A survey on Italian Patients with PMM2-CDG

Author

Barone, RITA MARIA ELISA, Carrozzi, M, Cosentini, D, Dionisi Vici, C, Di Rocco, M, Garozzo, D, Lilliu, F, Spada, M, Sturiale, L, and Fiumara, Agata

Subjects
CDG, Glycosilation defects, PMM2 CDG
Published
2013

23. Use of a graphic table in the evaluation of handwriting skills, before and after a movement-based treatment, in a group of children with dysgraphia

Author

Bravar, L., Borean, M., Zin, R., Accardo, Agostino, Scabar, A., Zoia, S., Carrozzi, M., L., Bravar, M., Borean, R., Zin, Accardo, Agostino, A., Scabar, S., Zoia, and M., Carrozzi

Subjects
DCD (developmental coordination disorder)- Spatial analysis-Visual-constructive abilities-Longitudinal study- School age children, Handwriting kinematics
Published
2005

25. A nationwide survey of PMM2-CDG in Italy: high frequency of a mild neurological variant associated with the L32R mutation

Author

Barone, Rita, primary, Carrozzi, M., additional, Parini, R., additional, Battini, R., additional, Martinelli, D., additional, Elia, M., additional, Spada, M., additional, Lilliu, F., additional, Ciana, G., additional, Burlina, A., additional, Leuzzi, V., additional, Leoni, M., additional, Sturiale, L., additional, Matthijs, G., additional, Jaeken, J., additional, Di Rocco, M., additional, Garozzo, D., additional, and Fiumara, A., additional

Published
2014
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27. Genotype-phenotype correlation in Italian CDG patients

Author

Barone, RITA MARIA ELISA, DI ROCCO, M, Dionisivici, C, Carrozzi, M, Spada, M, Pagliardini, S, Parini, R, Lilliu, F, Iannetti, P, Roccella, M, Deodato, F, Elia, M, Annesi, G, Quattrone, A, Jaeken, J, Fiumara, Agata, Pavone, L, Schollen, E, and Matthijs, G.

Published
2003

28. Genotype-phenotype correlation in Italian CDG-la patients

Author

Barone R., Di Rocco M., Dionisi-Vici, Carrozzi M., Spada M., Pagliardini S., Parini R., Lilliu F., Iannetti P., Roccella M., Deodato F., Elia M., Annesi G., Quattrone A., Jaeken J., Fiumara A., Pavone L., Scollen E., and Matthijs G.

Published
2003

39. A device for quantitative kinematic analysis of children's handwriting movements.

Author

Jarm, Tomaz, Kramar, Peter, Zupanic, Anze, Accardo, Agostino, Chiap, A., Borean, M., Bravar, L., Zoia, S., Carrozzi, M., and Scabar, A.

Abstract

Kinematic analysis of handwriting is a promising new frontier towards the characterization of handwriting movements, both in children and adults, with and without difficulties or pathologies that disrupt normal handwriting processes. The challenge, however, is to define and measure parameters that tap and highlight underlying mechanisms and strategies in order to comprehend such disorders, promote prevention programs and provide treatment or remedy, whenever possible. This work represents a practical application, binding neuropsychologic theory and engineering technology in the development of a device that enables on-line process analysis of handwriting, offering ample possibilities of research, both in medical and educational fields. Although employing complex mathematical procedures, the device is user friendly in its interface design and allows the rapid analysis of the parameters reported in literature, as well as some new and interesting variables that may contribute to the understanding of handwriting difficulties. The device has been successfully tested and used in a major Italian institute for childcare and research to evaluate handwriting proficiency in children. Preliminary results indicate that kinematic analysis of handwriting thus performed provides important information for the diagnosis and treatment of dysgraphia. [ABSTRACT FROM AUTHOR]

Published
2007
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41. Endozepine Stupor in Children

Author

Soriani, S, primary, Carrozzi, M, additional, De Carlo, L, additional, Plazzi, G, additional, Provini, F, additional, Rothstein, JD, additional, Tinuper, P, additional, Bouquet, F, additional, Lugaresi, E, additional, and Montagna, P, additional

Published
1997
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44. A comparison of the reach-to-grasp movement between children and adults: a kinematic study.

Author

Zoia S, Pezzetta E, Blason L, Scabar A, Carrozzi M, Bulgheroni M, and Castiello U

Abstract

In this study, the reach-to-grasp movement of 5-year-old children was compared to that of adults. Participants were required to reach out and grasp objects, with and without on-line visual feedback. Object size and distance were covaried in a within-subjects design and it was found that for both groups, grip formation and reach kinematics were affected by the manipulation of either variable. Although there are a large number of similarities, a few differences between the two groups emerge. For the reaching component, the children revealed a longer movement duration and deceleration time and a lower maximum height of wrist trajectory than in adults. For the grasp component, the children, in both the vision and no-vision condition, show a maximal finger aperture larger than the adults. Further, the children of this study were able to scale their grip aperture according to object size when visual feedback during the movement was lacking. These findings suggest that children adopt different strategies than adults when planning a reach-to-grasp movement on the basis of object size, distance, and the predictability of visual feedback. The results are discussed in terms of the neural mechanisms underlying hand action and how these mechanisms may not be fully developed by the age of 5. [ABSTRACT FROM AUTHOR]

Published
2006
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