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9. Diet and Carcinogenesis

Author

Carroll, K. K., Schettler, F. Gotthard, editor, Gotto, Antonio M., Jr., editor, Middelhoff, Gert, editor, Habenicht, Andreas J. R., editor, and Jurutka, Klara R., editor

Published
1983
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34. Obesity:Preventing and managing the global epidemic

Author

Akram, D. S., Astrup, Arne, Atinmo, T., Boissin, J. L., Bray, G. A., Carroll, K. K., Chitson, P., Chunming, C., Dietz, W. H., Hill, J. O., Jéquier, E., Komodiki, C., Matsuzawa, Y., Mollentze, W. F., Moosa, K., Noor, M. I., Reddy, K. S., Seidell, J., Tanphaichitr, V., Uauy, R., Zimmet, P., Akram, D. S., Astrup, Arne, Atinmo, T., Boissin, J. L., Bray, G. A., Carroll, K. K., Chitson, P., Chunming, C., Dietz, W. H., Hill, J. O., Jéquier, E., Komodiki, C., Matsuzawa, Y., Mollentze, W. F., Moosa, K., Noor, M. I., Reddy, K. S., Seidell, J., Tanphaichitr, V., Uauy, R., and Zimmet, P.

Published
2000

36. Nutrition and disease update. Cancer

Author

Carroll, K. K. (Kenneth Kitchener), Kritchevsky, David, 1920-2006., Carroll, K. K. (Kenneth Kitchener), and Kritchevsky, David, 1920-2006.

Published
1994

38. Irish cardiac society - Proceedings of annual general meeting held 20th & 21st November 1992 in Dublin Castle

Author

Cullen, C., MacKenzie, G. (G.), Adgey, J. (Jennifer), Lavin, F., Keane, M. (Michael), Forde, A. (A.), Shah, P. (P.), Gannon, F. (F.), Daly, K. (Kieran), McClements, B.M. (B.), McNeil, C.M. (Catriona), Wilson, C.M. (C.), Webb, S.W. (S.), Campbell, N.P.S., Khan, M.M. (M.), O'Murchu, B. (B.), Gersh, B.J. (Bernard), Bailey, K.R. (K.), Holmes, D.R. (David), Foley, D.P. (David), Hermans, W.R. (W.), Rensing, B.J. (B.), Vos, J. (Jeroen), Herman, J.-P. (J.), Serruys, P.W.J.C. (Patrick), Mannion, A. (Alex), Finn, J. (J.), Grimes, J., Lonergan, M. (Moira), O'Donnell, A. (Aonghus), Daly, L. (L.), McGovern, E., Graham, I., Joseph, P.A. (P.), Robinson, K. (K.), Kinsella, T. (T.), Crean, P.A. (Peter), Gearty, G., Walsh, M., Ryan, M. (M.), Clarke, R. (Robert), Refsum, H., Ueland, P.M. (Per), Coehrane, D.J. (D.), Stewart, A.J. (A.), McEneaney, D.J. (David), Allen, J.D. (Desmond), Anderson, J. (John), Dempsey, G., Adgey, A.A.J., Casey, F.A. (F.), Mulholland, H.C., Craig, B.G., Power, R. (R.), Rooney, N. (N.), O'Keeffe, D. (D.), McComb, J. (J.), Tan, K.S., Pye, S.R. (Stephen), McCabe, M. (Marita), Hickey, B.B., Cochrane, D. (D.), Oslizlok, P.C. (P.), Case, L. (Laura), Gillette, P.C. (P.), Knick, B.J. (Barbara), Henry, L.P.N. (L. P N), Blair, L. (L.), Gumbrielle, T. (T.), Bourke, B. (Billy), Hilton, G. (Gina), Campbell, R.W.F. (R. W F), Kearney, P. (Peter), Fennell, F. (F.), McKiernan, E., Fennell, W. (W.), Escaned, J. (J.), Umans, V.A.W.M. (Victor), Jaegere, P.P.T. (Peter) de, Feyter, P.J. (Pim) de, Galvin, J., Leavey, S., Sugrue, D., Vallely, S.R. (Stephen), Laird, J.D. (J.), Ferguson, R. (R.), Duff, S. (S.), Bridges, A.B. (A.), Pringle, T.H. (T.), McNeill, N.H. (Nathan), McLaren, M. (M.), Belch, A., O'Sullivan, L. (L.), Bain, L.J. (Lisa), Hunter, S. (S.), Wren, D. (Dörte), Hennesy, A. (A.), Codd, M., Daly, C.A. (Caroline), McCarthy, C., Carroll, K. (K.), Coakley, F. (F.), O'Mahony, J.F. (James), Sullivan, P.A. (P.), Higgins, T. (T.), Crowey, J.J. (J.), Donnelly, S.M. (S.), Tobin, M. (Martin), FitzGerald, E.V.K., Bresnihan, B., Maurer, B.J. (Barry), Quigley, P.J. (P.), Shelley, E. (Emer), Collins, C. (C.), ulcahy, R. (R.), Johnston, P.W., Gibson, J. (Jane), Crowe, S. (Suzanne), King, G., Freyne, P.J. (P.), Geary, P., McAdam, B. (B.), Sheahan, R., Gaylani, N.E. (N.EL), Simpson, A. (A.), Temperley, I. (I.), Mulcahy, D., McGee, H.M., Graham, T. (Tracy), Horgan, J.H., McGinley, J. (J.), Hurley, J. (J.), Neligan, M. (M.), Austin, P.C. (Peter), Cleland, J. (J.), Gladstone, D. (D.), O'Kane, H. (H.), O'Sullivan, J. (J.), Hasan, A. (A.), Hamilton, J.R.L. (J. R L), Dark, J.H. (J.), McDaid, C.M. (C.), Phillips, A.S. (A.), Lewis, S.A. (S.), McMurray, J.J.V. (John), Walsh, K. (K.), Abrams, D., Diamond, M. (M.), Clarkson, M.J. (M.), Rutsch, W.R. (Wolfgang), Emanuelsson, H. (H.), Danchin, N. (Nicolas), Wijns, W. (William), Chappuis, F., Cullen, C., MacKenzie, G. (G.), Adgey, J. (Jennifer), Lavin, F., Keane, M. (Michael), Forde, A. (A.), Shah, P. (P.), Gannon, F. (F.), Daly, K. (Kieran), McClements, B.M. (B.), McNeil, C.M. (Catriona), Wilson, C.M. (C.), Webb, S.W. (S.), Campbell, N.P.S., Khan, M.M. (M.), O'Murchu, B. (B.), Gersh, B.J. (Bernard), Bailey, K.R. (K.), Holmes, D.R. (David), Foley, D.P. (David), Hermans, W.R. (W.), Rensing, B.J. (B.), Vos, J. (Jeroen), Herman, J.-P. (J.), Serruys, P.W.J.C. (Patrick), Mannion, A. (Alex), Finn, J. (J.), Grimes, J., Lonergan, M. (Moira), O'Donnell, A. (Aonghus), Daly, L. (L.), McGovern, E., Graham, I., Joseph, P.A. (P.), Robinson, K. (K.), Kinsella, T. (T.), Crean, P.A. (Peter), Gearty, G., Walsh, M., Ryan, M. (M.), Clarke, R. (Robert), Refsum, H., Ueland, P.M. (Per), Coehrane, D.J. (D.), Stewart, A.J. (A.), McEneaney, D.J. (David), Allen, J.D. (Desmond), Anderson, J. (John), Dempsey, G., Adgey, A.A.J., Casey, F.A. (F.), Mulholland, H.C., Craig, B.G., Power, R. (R.), Rooney, N. (N.), O'Keeffe, D. (D.), McComb, J. (J.), Tan, K.S., Pye, S.R. (Stephen), McCabe, M. (Marita), Hickey, B.B., Cochrane, D. (D.), Oslizlok, P.C. (P.), Case, L. (Laura), Gillette, P.C. (P.), Knick, B.J. (Barbara), Henry, L.P.N. (L. P N), Blair, L. (L.), Gumbrielle, T. (T.), Bourke, B. (Billy), Hilton, G. (Gina), Campbell, R.W.F. (R. W F), Kearney, P. (Peter), Fennell, F. (F.), McKiernan, E., Fennell, W. (W.), Escaned, J. (J.), Umans, V.A.W.M. (Victor), Jaegere, P.P.T. (Peter) de, Feyter, P.J. (Pim) de, Galvin, J., Leavey, S., Sugrue, D., Vallely, S.R. (Stephen), Laird, J.D. (J.), Ferguson, R. (R.), Duff, S. (S.), Bridges, A.B. (A.), Pringle, T.H. (T.), McNeill, N.H. (Nathan), McLaren, M. (M.), Belch, A., O'Sullivan, L. (L.), Bain, L.J. (Lisa), Hunter, S. (S.), Wren, D. (Dörte), Hennesy, A. (A.), Codd, M., Daly, C.A. (Caroline), McCarthy, C., Carroll, K. (K.), Coakley, F. (F.), O'Mahony, J.F. (James), Sullivan, P.A. (P.), Higgins, T. (T.), Crowey, J.J. (J.), Donnelly, S.M. (S.), Tobin, M. (Martin), FitzGerald, E.V.K., Bresnihan, B., Maurer, B.J. (Barry), Quigley, P.J. (P.), Shelley, E. (Emer), Collins, C. (C.), ulcahy, R. (R.), Johnston, P.W., Gibson, J. (Jane), Crowe, S. (Suzanne), King, G., Freyne, P.J. (P.), Geary, P., McAdam, B. (B.), Sheahan, R., Gaylani, N.E. (N.EL), Simpson, A. (A.), Temperley, I. (I.), Mulcahy, D., McGee, H.M., Graham, T. (Tracy), Horgan, J.H., McGinley, J. (J.), Hurley, J. (J.), Neligan, M. (M.), Austin, P.C. (Peter), Cleland, J. (J.), Gladstone, D. (D.), O'Kane, H. (H.), O'Sullivan, J. (J.), Hasan, A. (A.), Hamilton, J.R.L. (J. R L), Dark, J.H. (J.), McDaid, C.M. (C.), Phillips, A.S. (A.), Lewis, S.A. (S.), McMurray, J.J.V. (John), Walsh, K. (K.), Abrams, D., Diamond, M. (M.), Clarkson, M.J. (M.), Rutsch, W.R. (Wolfgang), Emanuelsson, H. (H.), Danchin, N. (Nicolas), Wijns, W. (William), and Chappuis, F.

Published
1993
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47. Preview abstracts released!

Author

Miller, R. W., Earle, F. R., Albrecht, H., McBride, Jr., J. J., Stephens, R. L., Lawrence, R. V., Malins, D. C., Wekell, J. C., Houle, C. R., Dutton, H. J., Mounts, T. L., Allen, R. R., Pominski, J., Patton, E. L., Spadaro, J. J., Frankel, E. N., Maurer, E. W., Stirton, A. J., Ault, Waldo C., Weil, J. K., Haeberer, E. T., Maerker, G., Cooper, Robert S., Ginn, M. E., Anderson, R. M., Harris, J. C., Yu, T. C., Sinnhuber, Russell O., Litchfield, Carter, Reiser, Raymond, Isbell, A. F., Feldman, G. L., Pohle, W. D., Gregory, R. L., Tierney, S. E., Taylor, J. R., Harlow, Robert D., Privett, O. S., Christense Nickell, E., Nicolaides, N., Laves, Fritz, Theriault, Donald G., Pelick, Nicholas, Henly, Robert S., Sweeney, Robert F., Carroll, K. K., Rouser, George, Kritchevsky, Gene, Heller, Dorothy, Lieber, Ellen, and Vandenheuvel, F. A.

Published
1963
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48. Soy protein peptides regulate cholesterol homeostasis in Hep G2 cells.

Author

Lovati, Maria R., Manzoni, Cristina, Lovati, M R, Manzoni, C, Gianazza, E, Arnoldi, A, Kurowska, E, Carroll, K K, and Sirtori, C R

Subjects
PEPTIDES, HEPATOCELLULAR carcinoma, PHYSIOLOGY, CHOLESTEROL metabolism, AMINO acids, CELL receptors, DOCUMENTATION, ELECTROPHORESIS, ETHANOL, HEAT, HOMEOSTASIS, LIVER tumors, SOY proteins, CANCER cell culture, CELL physiology
Abstract

The activation of LDL receptors was described recently in a human hepatoma cell line (Hep G2) exposed both to alpha + alpha' subunits from 7S soy globulin and to Croksoy(R)70, a commercial isoflavone-poor soy concentrate. To assess the final identity of the peptide(s) putatively responsible for the biochemical effect, experiments were performed in Hep G2 cells, exposed either to synthetic peptides corresponding to specific sequences of 7S soy globulin or to peptides from the in vitro digestion of Croksoy(R)70. Moreover, the ability of the whole 7S globulin, its subunits and whole Croksoy(R)70 to interfere in the apolipoprotein B (apo B) secretion in the medium as well as in sterol biosynthesis was evaluated in the same model. Increased (125)I-LDL uptake and degradation vs. controls were shown after Hep G2 incubation with a synthetic peptide (10(-)(4) mol/L, MW 2271 Da) corresponding to positions 127-150 of the 7S globulin. Cells exposed to Croksoy(R)70 enzyme digestion products showed a more marked up-regulation of LDL receptors vs. controls, compared with vs. Hep G2 cells incubated with undigested Croksoy(R)70. Among soy-derived products, only the 7S globulin inhibited apo B secretion and (14)C-acetate incorporation when tested in Hep G2 cells at a concentration of 1.0 g/L. These findings support the hypothesis that if one or more peptides can reach the liver after intestinal digestion, they may elicit a cholesterol-lowering effect. Moreover, the protein moiety, devoid of isoflavone components, is likely to be responsible for this major biochemical effect of soy protein. [ABSTRACT FROM AUTHOR]

Published
2000
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49. Addition of arginine but not glycine to lysine plus methionine-enriched diets modulates serum cholesterol and liver phospholipids in rabbits.

Author

Giroux, Isabelle, Kurowska, Elzbieta M., Giroux, I, Kurowska, E M, Freeman, D J, and Carroll, K K

Subjects
AMINO acid metabolism, GLYCINE, LYSINE, BODY weight, METHIONINE, METABOLISM, METHIONINE metabolism, AMINO acids, ANALYSIS of variance, ANIMAL experimentation, ARGININE, CHOLESTEROL, COMPARATIVE studies, DIET, DRUG interactions, HYPERCHOLESTEREMIA, LIPOPROTEINS, LIVER, RESEARCH methodology, MEDICAL cooperation, PHOSPHOLIPIDS, RABBITS, RESEARCH, HOMOCYSTEINE, EVALUATION research
Abstract

Previous experiments from our laboratory showed that in rabbits fed an amino acid diet corresponding to 30% casein, enrichment of the diet with L-lysine and L-methionine caused a marked increase in serum total and LDL cholesterol levels as well as a substantial body weight loss. Both effects were partially prevented by supplementation with L-arginine. The present studies were designed to extend this earlier observation by assessing the role of different dietary amino acids in modulation of cholesterolemic responses and body weights. In the first experiment, the original lysine and methionine-enriched diet was supplemented with glycine in an attempt to modify methionine metabolism, and thus to reduce body weight loss. In addition, the mechanism of action of lysine and methionine was investigated by quantitation of major liver phospholipids. The results showed that glycine addition had no effect on weight loss or hypercholesterolemia, nor did it alter plasma levels of homocyst(e)ine, an intermediate in methionine metabolism. However, enrichment of the diet with lysine and methionine (with or without glycine) significantly increased liver levels of phosphatidylcholine and the ratio of phosphatidylcholine to phosphatidylethanolamine, apparently through increased enzymatic conversion. These changes were consistent with higher lipoprotein levels and thus may explain the hypercholesterolemia. A second experiment showed that similar effects on body weights and serum cholesterol could be obtained by adding lysine and methionine to a diet containing amino acids equivalent to only 15% casein, or 15% intact casein. This approach is more physiologic and also reduces the expense of experiments designed to study the effects of lysine and methionine in more detail. [ABSTRACT FROM AUTHOR]

Published
1999
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