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1. Immunization with V987H-stabilized Spike glycoprotein protects K18-hACE2 mice and golden Syrian hamsters upon SARS-CoV-2 infection

Author

Ávila-Nieto, Carlos, Vergara-Alert, Júlia, Amengual-Rigo, Pep, Ainsua-Enrich, Erola, Brustolin, Marco, Rodríguez de la Concepción, María Luisa, Pedreño-Lopez, Núria, Rodon, Jordi, Urrea, Victor, Pradenas, Edwards, Marfil, Silvia, Ballana, Ester, Riveira-Muñoz, Eva, Pérez, Mònica, Roca, Núria, Tarrés-Freixas, Ferran, Cantero, Guillermo, Pons-Grífols, Anna, Rovirosa, Carla, Aguilar-Gurrieri, Carmen, Ortiz, Raquel, Barajas, Ana, Trinité, Benjamin, Lepore, Rosalba, Muñoz-Basagoiti, Jordana, Perez-Zsolt, Daniel, Izquierdo-Useros, Nuria, Valencia, Alfonso, Blanco, Julià, Guallar, Victor, Clotet, Bonaventura, Segalés, Joaquim, and Carrillo, Jorge

Published
2024
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2. Immunisation efficacy of a stabilised SARS-CoV-2 spike glycoprotein in two geriatric animal models

Author

Usai, Carla, Ainsua-Enrich, Erola, Gales, Victor Urrea, Pradenas, Edwards, Lorca-Oró, Cristina, Tarrés-Freixas, Ferran, Roca, Núria, Pérez, Mónica, Ávila-Nieto, Carlos, Rodríguez de la Concepción, María Luisa, Pedreño-Lopez, Núria, Carabelli, Julieta, Trinité, Benjamin, Ballana, Ester, Riveira-Muñoz, Eva, Izquierdo-Useros, Nuria, Clotet, Bonaventura, Blanco, Julià, Guallar, Victor, Cantero, Guillermo, Vergara-Alert, Júlia, Carrillo, Jorge, and Segalés, Joaquim

Published
2024
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3. Virus-like particle-mediated delivery of structure-selected neoantigens demonstrates immunogenicity and antitumoral activity in mice

Author

Barajas, Ana, Amengual-Rigo, Pep, Pons-Grífols, Anna, Ortiz, Raquel, Gracia Carmona, Oriol, Urrea, Victor, de la Iglesia, Nuria, Blanco-Heredia, Juan, Anjos-Souza, Carla, Varela, Ismael, Trinité, Benjamin, Tarrés-Freixas, Ferran, Rovirosa, Carla, Lepore, Rosalba, Vázquez, Miguel, de Mattos-Arruda, Leticia, Valencia, Alfonso, Clotet, Bonaventura, Aguilar-Gurrieri, Carmen, Guallar, Victor, Carrillo, Jorge, and Blanco, Julià

Published
2024
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4. Adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection: an individual participant data meta-analysis

Author

Smith, Emily R, Oakley, Erin, Grandner, Gargi Wable, Ferguson, Kacey, Farooq, Fouzia, Afshar, Yalda, Ahlberg, Mia, Ahmadzia, Homa, Akelo, Victor, Aldrovandi, Grace, Barr, Beth A Tippett, Bevilacqua, Elisa, Brandt, Justin S, Broutet, Nathalie, Buhigas, Irene Fernández, Carrillo, Jorge, Clifton, Rebecca, Conry, Jeanne, Cosmi, Erich, Crispi, Fatima, Crovetto, Francesca, Delgado-López, Camille, Divakar, Hema, Driscoll, Amanda J, Favre, Guillaume, Flaherman, Valerie J, Gale, Chris, Gil, Maria M, Gottlieb, Sami L, Gratacós, Eduard, Hernandez, Olivia, Jones, Stephanie, Kalafat, Erkan, Khagayi, Sammy, Knight, Marian, Kotloff, Karen, Lanzone, Antonio, Le Doare, Kirsty, Lees, Christoph, Litman, Ethan, Lokken, Erica M, Longo, Valentina Laurita, Madhi, Shabir A, Magee, Laura A, Martinez-Portilla, Raigam Jafet, McClure, Elizabeth M, Metz, Tori D, Miller, Emily S, Money, Deborah, Moungmaithong, Sakita, Mullins, Edward, Nachega, Jean B, Nunes, Marta C, Onyango, Dickens, Panchaud, Alice, Poon, Liona C, Raiten, Daniel, Regan, Lesley, Rukundo, Gordon, Sahota, Daljit, Sakowicz, Allie, Sanin-Blair, Jose, Söderling, Jonas, Stephansson, Olof, Temmerman, Marleen, Thorson, Anna, Tolosa, Jorge E, Townson, Julia, Valencia-Prado, Miguel, Visentin, Silvia, von Dadelszen, Peter, Waldorf, Kristina Adams, Whitehead, Clare, Yassa, Murat, Tielsch, Jim M, Langenegger, Eduard, Sam-Agudu, Nadia A, Gachuno, Onesmus W, Sekikubo, Musa, Mukwege, Denis M, Omore, Richard, Ouma, Gregory, Onyango, Clayton, Otieno, Kephas, Were, Zacchaeus Abaja, Were, Joyce, İlter, Pinar Birol, Mboizi, Robert, Hookham, Lauren, Meli, Federica, Bonanni, Giulia, Romanzi, Federica, Torcia, Eleonora, di Ilio, Chiara, Ananth, Cande V, Hill, Jennifer, Reddy, Ajay, Patrick, Haylea Sweat, Baba, Vuyelwa, and Adam, Mary

Subjects
Biodefense, Pneumonia, Lung, Infant Mortality, Vaccine Related, Emerging Infectious Diseases, Clinical Trials and Supportive Activities, Clinical Research, Pediatric, Perinatal Period - Conditions Originating in Perinatal Period, Preterm, Low Birth Weight and Health of the Newborn, Infectious Diseases, Prevention, Pneumonia & Influenza, Infection, Reproductive health and childbirth, Good Health and Well Being, Infant, Newborn, Pregnancy, Female, Humans, Pregnant Women, Prospective Studies, COVID-19, SARS-CoV-2, Maternal health, Epidemiology, Perinatal COVID PMA Study Collaborators
Abstract

IntroductionDespite a growing body of research on the risks of SARS-CoV-2 infection during pregnancy, there is continued controversy given heterogeneity in the quality and design of published studies.MethodsWe screened ongoing studies in our sequential, prospective meta-analysis. We pooled individual participant data to estimate the absolute and relative risk (RR) of adverse outcomes among pregnant women with SARS-CoV-2 infection, compared with confirmed negative pregnancies. We evaluated the risk of bias using a modified Newcastle-Ottawa Scale.ResultsWe screened 137 studies and included 12 studies in 12 countries involving 13 136 pregnant women.Pregnant women with SARS-CoV-2 infection-as compared with uninfected pregnant women-were at significantly increased risk of maternal mortality (10 studies; n=1490; RR 7.68, 95% CI 1.70 to 34.61); admission to intensive care unit (8 studies; n=6660; RR 3.81, 95% CI 2.03 to 7.17); receiving mechanical ventilation (7 studies; n=4887; RR 15.23, 95% CI 4.32 to 53.71); receiving any critical care (7 studies; n=4735; RR 5.48, 95% CI 2.57 to 11.72); and being diagnosed with pneumonia (6 studies; n=4573; RR 23.46, 95% CI 3.03 to 181.39) and thromboembolic disease (8 studies; n=5146; RR 5.50, 95% CI 1.12 to 27.12).Neonates born to women with SARS-CoV-2 infection were more likely to be admitted to a neonatal care unit after birth (7 studies; n=7637; RR 1.86, 95% CI 1.12 to 3.08); be born preterm (7 studies; n=6233; RR 1.71, 95% CI 1.28 to 2.29) or moderately preterm (7 studies; n=6071; RR 2.92, 95% CI 1.88 to 4.54); and to be born low birth weight (12 studies; n=11 930; RR 1.19, 95% CI 1.02 to 1.40). Infection was not linked to stillbirth. Studies were generally at low or moderate risk of bias.ConclusionsThis analysis indicates that SARS-CoV-2 infection at any time during pregnancy increases the risk of maternal death, severe maternal morbidities and neonatal morbidity, but not stillbirth or intrauterine growth restriction. As more data become available, we will update these findings per the published protocol.

Published
2023

5. Immune responses associated with mpox viral clearance in men with and without HIV in Spain: a multisite, observational, prospective cohort study

Author

Alarcón Soto, Yovaninna, Alemany, Andrea, Bailón, Lucía, Benet, Susana, Mitjà, Oriol, Mothe, Beatriz, Paredes, Roger, Sabato, Sofía, Suñer, Clara, Torrano, Pamela, Ubals, Maria, Boreika, Rytis, Brander, Christian, Carabelli, Julieta, Carrillo, Jorge, Gallemí, Marçal, Izquierdo-Useros, Nuria, Molina-Molina, Elisa, Moraes-Cardoso, Igor, Muñoz-Basagoiti, Jordana, Olvera, Alex, Perez-Zsolt, Daniel, Raïch-Regué, Dàlia, Coll, Pep, Fernández, Javier, Mendoza, Adrià, Pérez, Félix, Reguant, Joan, Rivero, Angel, Arando, Maider, Descalzo, Vicente, Néstor Garcia, Jorge, Monforte, Arnau, Álvarez, Patricia, Guedj, Jeremie, Marc, Aurélien, Marks, Michael, Alarcón-Soto, Yovaninna, Grifoni, Alba, Sette, Alessandro, and Moltó, José

Published
2024
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6. World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project: V. Physical examination standards in endometriosis research

Author

Andersson, Elisabet, Carrillo, Jorge, Cox, Emma, Celik, Hale Goksever, Horne, Andrew W., James, Akaiti, Lamvu, Georgine, Martin, Dan C., Nwankudu, Olivia C., Tu, Frank F., Lin, Tinya, Allaire, Catherine, As-Sanie, Sawsan, Stratton, Pamela, Vincent, Katy, Adamson, G. David, Arendt-Nielsen, Lars, Bush, Deborah, Jansen, Femke, Longpre, Jennifer, Rombauts, Luk, Shah, Jay, Toussaint, Abeesha, Hummelshoj, Lone, Missmer, Stacey A., and Yong, Paul J.

Published
2024
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10. An engineered HIV-1 Gag-based VLP displaying high antigen density induces strong antibody-dependent functional immune responses

Author

Tarrés-Freixas, Ferran, Aguilar-Gurrieri, Carmen, Rodríguez de la Concepción, María Luisa, Urrea, Victor, Trinité, Benjamin, Ortiz, Raquel, Pradenas, Edwards, Blanco, Pau, Marfil, Sílvia, Molinos-Albert, Luis Manuel, Barajas, Ana, Pons-Grífols, Anna, Ávila-Nieto, Carlos, Varela, Ismael, Cervera, Laura, Gutiérrez-Granados, Sònia, Segura, María Mercedes, Gòdia, Francesc, Clotet, Bonaventura, Carrillo, Jorge, and Blanco, Julià

Published
2023
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13. T-Follicular-Like CD8+ T Cell Responses in Chronic HIV Infection Are Associated With Virus Control and Antibody Isotype Switching to IgG

Author

Romero-Martín, Luis, Tarrés-Freixas, Ferran, Pedreño-López, Núria, de la Concepción, Maria L Rodríguez, Cunyat, Francesc, Hartigan-O'Connor, Dennis, Carrillo, Jorge, Mothe, Beatriz, Blanco, Julià, Ruiz-Riol, Marta, Brander, Christian, and Olvera, Alex

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Immunology, Infectious Diseases, Sexually Transmitted Infections, Immunization, Vaccine Related, Prevention, HIV/AIDS, Vaccine Related (AIDS), Infection, Good Health and Well Being, CD8-Positive T-Lymphocytes, Graft vs Host Disease, HIV Infections, Humans, Immunoglobulin Class Switching, Immunoglobulin G, Persistent Infection, HIV, humoral immune response, human immunodeficiency virus (HIV) control, T-follicular cytotoxic (Tfc) cells, viral control, Biochemistry and cell biology, Genetics
Abstract

T cell responses are considered critical for the in vivo control of HIV, but the contribution of different T cell subsets to this control remains unclear. Using a boosted flow cytometric approach that is able to differentiate CD4+ and CD8+ T cell Th1/Tc1, Th2/Tc2, Th17/Tc17, Treg and Tfh/Tfc-like HIV-specific T cell populations, we identified CD8+ Tfc responses that were related to HIV plasma viral loads and associated with rate of antibody isotype class switching to IgG. This favorable balance towards IgG responses positively correlated with increased virus neutralization, higher avidity of neutralizing antibodies and more potent antibody-dependent cell cytotoxicity (ADCC) in PBMCs from HIV controllers compared to non-controllers. Our results identified the CD8+ Tfc-like T-cell response as a component of effective virus control which could possibly be exploited therapeutically.

Published
2022

14. Protocol for a sequential, prospective meta-analysis to describe coronavirus disease 2019 (COVID-19) in the pregnancy and postpartum periods

Author

Smith, Emily R, Oakley, Erin, He, Siran, Zavala, Rebecca, Ferguson, Kacey, Miller, Lior, Grandner, Gargi Wable, Abejirinde, Ibukun-Oluwa Omolade, Afshar, Yalda, Ahmadzia, Homa, Aldrovandi, Grace, Akelo, Victor, Barr, Beth A Tippett, Bevilacqua, Elisa, Brandt, Justin S, Broutet, Natalie, Buhigas, Irene Fernández, Carrillo, Jorge, Clifton, Rebecca, Conry, Jeanne, Cosmi, Erich, Delgado-López, Camille, Divakar, Hema, Driscoll, Amanda J, Favre, Guillaume, Flaherman, Valerie, Gale, Christopher, Gil, Maria M, Godwin, Christine, Gottlieb, Sami, Bellolio, Olivia Hernandez, Kara, Edna, Khagayi, Sammy, Kim, Caron Rahn, Knight, Marian, Kotloff, Karen, Lanzone, Antonio, Le Doare, Kirsty, Lees, Christoph, Litman, Ethan, Lokken, Erica M, Longo, Valentina Laurita, Magee, Laura A, Martinez-Portilla, Raigam Jafet, McClure, Elizabeth, Metz, Torri D, Money, Deborah, Mullins, Edward, Nachega, Jean B, Panchaud, Alice, Playle, Rebecca, Poon, Liona C, Raiten, Daniel, Regan, Lesley, Rukundo, Gordon, Sanin-Blair, Jose, Temmerman, Marleen, Thorson, Anna, Thwin, Soe, Tolosa, Jorge E, Townson, Julia, Valencia-Prado, Miguel, Visentin, Silvia, von Dadelszen, Peter, Waldorf, Kristina Adams, Whitehead, Clare, Yang, Huixia, Thorlund, Kristian, and Tielsch, James M

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Health Sciences, Clinical Research, Emerging Infectious Diseases, Pediatric, Prevention, Reproductive health and childbirth, Good Health and Well Being, Adolescent, COVID-19, Child, Female, Humans, Infant, Newborn, Meta-Analysis as Topic, Postpartum Period, Pregnancy, Prospective Studies, Retrospective Studies, SARS-CoV-2, General Science & Technology
Abstract

We urgently need answers to basic epidemiological questions regarding SARS-CoV-2 infection in pregnant and postpartum women and its effect on their newborns. While many national registries, health facilities, and research groups are collecting relevant data, we need a collaborative and methodologically rigorous approach to better combine these data and address knowledge gaps, especially those related to rare outcomes. We propose that using a sequential, prospective meta-analysis (PMA) is the best approach to generate data for policy- and practice-oriented guidelines. As the pandemic evolves, additional studies identified retrospectively by the steering committee or through living systematic reviews will be invited to participate in this PMA. Investigators can contribute to the PMA by either submitting individual patient data or running standardized code to generate aggregate data estimates. For the primary analysis, we will pool data using two-stage meta-analysis methods. The meta-analyses will be updated as additional data accrue in each contributing study and as additional studies meet study-specific time or data accrual thresholds for sharing. At the time of publication, investigators of 25 studies, including more than 76,000 pregnancies, in 41 countries had agreed to share data for this analysis. Among the included studies, 12 have a contemporaneous comparison group of pregnancies without COVID-19, and four studies include a comparison group of non-pregnant women of reproductive age with COVID-19. Protocols and updates will be maintained publicly. Results will be shared with key stakeholders, including the World Health Organization (WHO) Maternal, Newborn, Child, and Adolescent Health (MNCAH) Research Working Group. Data contributors will share results with local stakeholders. Scientific publications will be published in open-access journals on an ongoing basis.

Published
2022

15. Ethnobotanical Science in the Clouds: Useful Plants of Northeastern Oaxaca, Mexico

Author

Rendón-Aguilar, Beatriz, Bravo-Avilez, David, Bernal-Ramírez, Luis Alberto, García-Mendoza, Abisaí, Espejo-Serna, Adolfo, López-Ferrari, Ana Rosa, Durán-Espinosa, Carlos, Gernandt, David S., Lorea-Hernández, Francisco, Ibarra-Manríquez, Guillermo, Jiménez-Ramírez, Jaime, de Santiago-Gómez, Jesús Ricardo, Santana-Carrillo, Jorge, Villaseñor, José Luis, Yáñez-Espinosa, Laura, Lozada-Pérez, Lucio, Samain, Marie-Stéphanie, Valencia-Ávalos, Susana, Fonseca-Juárez, Rosa María, Arias-Montes, Salvador, Bussmann, Rainer W., Series Editor, Paniagua-Zambrana, Narel Y., Series Editor, Casas, Alejandro, editor, and Blancas Vázquez, José Juan, editor

Published
2023
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16. β-Cyclodextrins as affordable antivirals to treat coronavirus infection

Author

Raïch-Regué, Dalia, Tenorio, Raquel, Fernández de Castro, Isabel, Tarrés-Freixas, Ferran, Sachse, Martin, Perez-Zsolt, Daniel, Muñoz-Basagoiti, Jordana, Fernández-Sánchez, Sara Y., Gallemí, Marçal, Ortega-González, Paula, Fernández-Oliva, Alberto, Gabaldón, José A., Nuñez-Delicado, Estrella, Casas, Josefina, Roca, Núria, Cantero, Guillermo, Pérez, Mónica, Usai, Carla, Lorca-Oró, Cristina, Alert, Júlia-Vergara, Segalés, Joaquim, Carrillo, Jorge, Blanco, Julià, Clotet Sala, Bonaventura, Cerón-Carrasco, José P., Izquierdo-Useros, Nuria, and Risco, Cristina

Published
2023
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17. SARS-CoV-2: Air pollution highly correlated to the increase in mortality. The case of Guadalajara, Jalisco, México

Author

Torres-Anguiano, Elizabeth, Sánchez-López, Itzel, Garduno-Robles, Angeles, Rivas-Carrillo, Jorge David, Rivera-León, Edgar Alfonso, Sánchez-Enríquez, Sergio, Ornelas-Hernández, Luis Fernando, Zazueta León-Quintero, Fernando, Salazar León-Quintero, Eduardo Narciso, Juárez-López, Guillermo Enrique, Sánchez-Zubieta, Fernando Antonio, Ochoa-Bru, Mariana, and Zepeda-Moreno, Abraham

Published
2023
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18. Macrophage CD5L is a target for cancer immunotherapy

Author

Sanchez-Moral, Lidia, Paul, Tony, Martori, Clara, Font-Díaz, Joan, Sanjurjo, Lucía, Aran, Gemma, Téllez, Érica, Blanco, Julià, Carrillo, Jorge, Ito, Masaoki, Tuttolomondo, Martina, Ditzel, Henrik J., Fumagalli, Caterina, Tapia, Gustavo, Sidorova, Julia, Masnou, Helena, Fernández-Sanmartín, Marco-Antonio, Lozano, Juan-José, Vilaplana, Cristina, Rodriguez-Cortés, Alhelí, Armengol, Carolina, Valledor, Annabel F., Kremer, Leonor, and Sarrias, Maria-Rosa

Published
2023
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19. Impact of hybrid immunity booster vaccination and Omicron breakthrough infection on SARS-CoV-2 VOCs cross-neutralization

Author

Pradenas, Edwards, Marfil, Silvia, Urrea, Víctor, Trigueros, Macedonia, Pidkova, Tetyana, Pons-Grífols, Anna, Ortiz, Raquel, Rovirosa, Carla, Tarrés-Freixas, Ferran, Aguilar-Gurrieri, Carmen, Toledo, Ruth, Chamorro, Anna, Noguera-Julian, Marc, Mateu, Lourdes, Blanco, Ignacio, Grau, Eulàlia, Massanella, Marta, Carrillo, Jorge, Clotet, Bonaventura, Trinité, Benjamin, and Blanco, Julià

Published
2023
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20. Clinical risk factors of adverse outcomes among women with COVID-19 in the pregnancy and postpartum period: a sequential, prospective meta-analysis

Author

Smith, Emily R., Oakley, Erin, Grandner, Gargi Wable, Rukundo, Gordon, Farooq, Fouzia, Ferguson, Kacey, Baumann, Sasha, Adams Waldorf, Kristina Maria, Afshar, Yalda, Ahlberg, Mia, Ahmadzia, Homa, Akelo, Victor, Aldrovandi, Grace, Bevilacqua, Elisa, Bracero, Nabal, Brandt, Justin S., Broutet, Natalie, Carrillo, Jorge, Conry, Jeanne, Cosmi, Erich, Crispi, Fatima, Crovetto, Francesca, del Mar Gil, Maria, Delgado-López, Camille, Divakar, Hema, Driscoll, Amanda J., Favre, Guillaume, Fernandez Buhigas, Irene, Flaherman, Valerie, Gale, Christopher, Godwin, Christine L., Gottlieb, Sami, Gratacós, Eduard, He, Siran, Hernandez, Olivia, Jones, Stephanie, Joshi, Sheetal, Kalafat, Erkan, Khagayi, Sammy, Knight, Marian, Kotloff, Karen L., Lanzone, Antonio, Laurita Longo, Valentina, Le Doare, Kirsty, Lees, Christoph, Litman, Ethan, Lokken, Erica M., Madhi, Shabir A., Magee, Laura A., Martinez-Portilla, Raigam Jafet, Metz, Torri D., Miller, Emily S., Money, Deborah, Moungmaithong, Sakita, Mullins, Edward, Nachega, Jean B., Nunes, Marta C., Onyango, Dickens, Panchaud, Alice, Poon, Liona C., Raiten, Daniel, Regan, Lesley, Sahota, Daljit, Sakowicz, Allie, Sanin-Blair, Jose, Stephansson, Olof, Temmerman, Marleen, Thorson, Anna, Thwin, Soe Soe, Tippett Barr, Beth A., Tolosa, Jorge E., Tug, Niyazi, Valencia-Prado, Miguel, Visentin, Silvia, von Dadelszen, Peter, Whitehead, Clare, Wood, Mollie, Yang, Huixia, Zavala, Rebecca, and Tielsch, James M.

Published
2023
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21. Short-Term Memory Reactivation of a Weak CS-US Association Promotes Long-Term Memory Persistence in Conditioned Odor Aversion

Author

Tovar-Díaz, Jorge, Morín, Jean-Pascal, Ríos-Carrillo, Jorge Eduardo, de Jesús, Hilda Sánchez, and Roldán-Roldán, Gabriel

Abstract

In conditioned odor aversion (COA), the association of a tasteless odorized solution (the conditioned stimulus [CS]) with an intraperitoneal injection of LiCl (the unconditioned stimulus [US]), which produces visceral malaise, results in its future avoidance. The strength of this associative memory is mainly dependent on two parameters, that is, the strength of the US and the interstimuli interval (ISI). In rats, COA has been observed only with ISIs of [less than or equal to] 15 min and LiCl (0.15 M) doses of 2.0% of bodyweight, when tested 48 h after acquisition (long-term memory [LTM]). However, we previously reported a robust aversion in rats trained with ISIs up to 60 min when tested 4 h after acquisition (short-term memory [STM]). Since memories get reactivated during retrieval, in the current study we hypothesized that testing for STM would reactivate this COA trace, strengthening its LTM. For this, we compared the LTM of rats trained with long ISIs or low doses of LiCl initially tested for STM with that of rats tested for LTM only. Interestingly, rats conditioned under parameters sufficient to produce STM, but not LTM, showed a reliable LTM when first tested for STM. These observations suggest that under suboptimal training conditions, such as long ISIs or low US intensities, a CS-US association is established but requires reactivation in the short-term in order to persist in the long-term.

Published
2021
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22. #2457 Effect of belimumab in renal function and proteinuria in patients with lupus nephritis (LN): our experience

Author

Liébana, Marc Patricio, primary, Romeo, Maria José Soler, additional, Hernández, Josefina Cortés, additional, Gabaldón, María Alejandra, additional, Carrillo, Jorge Ivan Zamora, additional, Lopez, Marina, additional, Borda, Jhusel Rosas, additional, Garcia, Sheila Bermejo, additional, Berna, Gerson, additional, Leon, Juan Carlos, additional, Matamoros, Oriol Bestard, additional, and Pamplona, Irene Agraz, additional

Published
2024
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23. #1475 Anti-neutrophil cytoplasmic antibodies (ANCA) associated vasculitis (AAV) with glomerulonephritis (AAV-GN) in real world life

Author

Liébana, Marc Patricio, primary, Lopez, Marina, additional, Carrillo, Jorge Ivan Zamora, additional, Garcia, Sheila Bermejo, additional, Pamplona, Irene Agraz, additional, Terrades, Natàlia Ramos, additional, Azancot, Maria, additional, Gaibor, Néstor Toapanta, additional, Berna, Gerson, additional, Leon, Juan Carlos, additional, Matamoros, Oriol Bestard, additional, and Romeo, Maria José Soler, additional

Published
2024
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25. Kinetics of immune responses elicited after three mRNA COVID-19 vaccine doses in predominantly antibody-deficient individuals

Author

Ainsua-Enrich, Erola, Pedreño-Lopez, Núria, Bracke, Carmen, Ávila-Nieto, Carlos, Rodríguez de la Concepción, María Luisa, Pradenas, Edwards, Trinité, Benjamin, Marfil, Silvia, Miranda, Cristina, González, Sandra, Toledo, Ruth, Font, Marta, Benet, Susana, Escribà, Tuixent, Jimenez-Moyano, Esther, Peña, Ruth, Cedeño, Samandhy, Prado, Julia G., Mothe, Beatriz, Brander, Christian, Izquierdo-Useros, Nuria, Vergara-Alert, Julia, Segalés, Joaquim, Massanella, Marta, Benitez, Rosa María, Romero, Alba, Molina-Morant, Daniel, Blanco, Julià, Clotet, Bonaventura, Mateu, Lourdes, Pedro-Botet, María Luisa, and Carrillo, Jorge

Published
2022
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28. Sodium Carbonate versus Borate Buffer for Lactase Quenching, Laboratory Work

Author

Ramos-de-la-Peña, Ana Mayela, Mercado-Valenzo, Oscar Mario, Clorio-Carrillo, Jorge Abraham, López-Incio, Jazmin Dessiret, Monroy-Borrego, Andrea Gabriela, Marrero-Bretado, Mariana Monserrat, González-Valdez, José, and Aguilar, Oscar

Abstract

A laboratory exercise for undergraduate advanced students of enzymology and biocatalysis is presented. Since enzyme assays can be quenched or continuous, this experiment compares the performance of two quenching agents for lactase, in a continuous setup. Enzymatic activity of [beta]-galactosidase ("Aspergillus oryzae") was determined based on the release of 4-nitrophenol from 4-nitrophenyl [beta]-D-galactopyranoside using a microplate reader. Sodium carbonate and borate buffer were tested as quenching agents, and experimental control was the unstopped assay. Based on released 4-nitrophenol, enzyme activity, and rate constant k, the students could assess the performance of each termination agent. The experiment promotes disciplinary and transversal competencies, including research-based learning, critical thinking, and introduce the students to high-throughput techniques that are common in the research and development environment.

Published
2021
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30. Biomarker candidates for progression and clinical management of COVID-19 associated pneumonia at time of admission

Author

Calvet, Joan, Berenguer-Llergo, Antoni, Gay, Marina, Massanella, Marta, Domingo, Pere, Llop, Maria, Sánchez-Jiménez, Ester, Arévalo, Marta, Carrillo, Jorge, Albiñana, Néstor, Arauz-Garofalo, Gianluca, Orellana, Cristóbal, Delgado, Juan Francisco, Serrano, Alejandra, Llobell, Artur, Graell, Eduard, García-Manrique, María, Moreno, Mireia, Galisteo, Carlos, Casado, Enrique, Navarro, Noemí, Gómez, Antoni, Garcia-Cirera, Silvia, Rusiñol, Menna, Costa, Ester, Clotet, Bonaventura, Vilaseca, Marta, Blanco, Julià, and Gratacós, Jordi

Published
2022
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32. Clinical course impacts early kinetics,magnitude, and amplitude of SARS-CoV-2 neutralizing antibodies beyond 1 year after infection

Author

Pradenas, Edwards, Trinité, Benjamin, Urrea, Víctor, Marfil, Silvia, Tarrés-Freixas, Ferran, Ortiz, Raquel, Rovirosa, Carla, Rodon, Jordi, Vergara-Alert, Júlia, Segalés, Joaquim, Guallar, Victor, Valencia, Alfonso, Izquierdo-Useros, Nuria, Noguera-Julian, Marc, Carrillo, Jorge, Paredes, Roger, Mateu, Lourdes, Chamorro, Anna, Toledo, Ruth, Massanella, Marta, Clotet, Bonaventura, and Blanco, Julià

Published
2022
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36. World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project: V. physical examination standards in endometriosis research

Author

Lin, Tinya, primary, Allaire, Catherine, additional, As-Sanie, Sawsan, additional, Stratton, Pamela, additional, Vincent, Katy, additional, Adamson, G. David, additional, Arendt-Nielsen, Lars, additional, Bush, Deborah, additional, Jansen, Femke, additional, Longpre, Jennifer, additional, Rombauts, Luk, additional, Shah, Jay, additional, Toussaint, Abeesha, additional, Hummelshoj, Lone, additional, Missmer, Stacy A., additional, Yong, Paul J., additional, Andersson, Elisabet, additional, Carrillo, Jorge, additional, Cox, Emma, additional, Celik, Hale Goksever, additional, Horne, Andrew W., additional, James, Akaiti, additional, Lamvu, Georgine, additional, Martin, Dan C., additional, Nwankudu, Olivia C., additional, and Tu, Frank F., additional

Published
2024
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39. Surgical Management of Endometriosis

Author

Carrillo, Jorge F., Lozada-Capriles, Yolianne, Allahbadia, Gautam Nand, editor, Ata, Baris, editor, Lindheim, Steven R., editor, Woodward, Bryan J., editor, and Bhagavath, Bala, editor

Published
2020
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40. Detection of SARS-CoV-2 in a cat owned by a COVID-19–affected patient in Spain

Author

Segalés, Joaquim, Puig, Mariona, Rodon, Jordi, Avila-Nieto, Carlos, Carrillo, Jorge, Cantero, Guillermo, Terrón, Maria Teresa, Cruz, Sílvia, Parera, Mariona, Noguera-Julián, Marc, Izquierdo-Useros, Nuria, Guallar, Víctor, Vidal, Enric, Valencia, Alfonso, Blanco, Ignacio, Blanco, Julià, Clotet, Bonaventura, and Vergara-Alert, Júlia

Published
2020

43. Ethnobotanical Science in the Clouds: Useful Plants of Northeastern Oaxaca, Mexico

Author

Rendón-Aguilar, Beatriz, primary, Bravo-Avilez, David, additional, Bernal-Ramírez, Luis Alberto, additional, García-Mendoza, Abisaí, additional, Espejo-Serna, Adolfo, additional, López-Ferrari, Ana Rosa, additional, Durán-Espinosa, Carlos, additional, Gernandt, David S., additional, Lorea-Hernández, Francisco, additional, Ibarra-Manríquez, Guillermo, additional, Jiménez-Ramírez, Jaime, additional, de Santiago-Gómez, Jesús Ricardo, additional, Santana-Carrillo, Jorge, additional, Villaseñor, José Luis, additional, Yáñez-Espinosa, Laura, additional, Lozada-Pérez, Lucio, additional, Samain, Marie-Stéphanie, additional, Valencia-Ávalos, Susana, additional, Fonseca-Juárez, Rosa María, additional, and Arias-Montes, Salvador, additional

Published
2022
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44. Single-cell multi-omics analysis of COVID-19 patients with pre-existing autoimmune diseases shows aberrant immune responses to infection

Author

Gates Cambridge Scholarships, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Chan Zuckerberg Biohub, Wellcome Sanger Institute, Josep Carreras Leukemia Foundation, Andrés-León, Eduardo [0000-0002-0621-9914], https://ror.org/02gfc7t72, Barmada, Anis, Handfield, Louis-François, Godoy-Tena, Gerard, de la Calle-Fabregat, Carlos, Ciudad, Laura, Arutyunyan, Anna, Andrés-León, Eduardo, Hoo, Regina, Porter, Tarryn, Oszlanczi, Agnes, Richardson, Laura, Calero-Nieto, Fernando J., Wilson, Nicola K., Marchese, Domenica, Sancho-Serra, Carmen, Carrillo, Jorge, Presas-Rodríguez, Silvia, Ramo-Tello, Cristina, Ruiz-Sanmartin, Adolfo, Ferrer, Ricard, Ruiz-Rodriguez, Juan Carlos, Martínez-Gallo, Mónica, Munera-Campos, Mónica, Carrascosa, Jose Manuel, Göttgens, Berthold, Heyn, Holger, Prigmore, Elena, Casafont-Solé, Ivette, Solanich, Xavier, Sánchez-Cerrillo, Ildefonso, González-Álvaro, Isidoro, Raimondo, Maria Gabriella, Ramming, Andreas, Martin, Javier, Martínez-Cáceres, Eva, Ballestar, Esteban, Vento-Tormo, Roser, Rodríguez-Ubreva, Javier, Gates Cambridge Scholarships, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Chan Zuckerberg Biohub, Wellcome Sanger Institute, Josep Carreras Leukemia Foundation, Andrés-León, Eduardo [0000-0002-0621-9914], https://ror.org/02gfc7t72, Barmada, Anis, Handfield, Louis-François, Godoy-Tena, Gerard, de la Calle-Fabregat, Carlos, Ciudad, Laura, Arutyunyan, Anna, Andrés-León, Eduardo, Hoo, Regina, Porter, Tarryn, Oszlanczi, Agnes, Richardson, Laura, Calero-Nieto, Fernando J., Wilson, Nicola K., Marchese, Domenica, Sancho-Serra, Carmen, Carrillo, Jorge, Presas-Rodríguez, Silvia, Ramo-Tello, Cristina, Ruiz-Sanmartin, Adolfo, Ferrer, Ricard, Ruiz-Rodriguez, Juan Carlos, Martínez-Gallo, Mónica, Munera-Campos, Mónica, Carrascosa, Jose Manuel, Göttgens, Berthold, Heyn, Holger, Prigmore, Elena, Casafont-Solé, Ivette, Solanich, Xavier, Sánchez-Cerrillo, Ildefonso, González-Álvaro, Isidoro, Raimondo, Maria Gabriella, Ramming, Andreas, Martin, Javier, Martínez-Cáceres, Eva, Ballestar, Esteban, Vento-Tormo, Roser, and Rodríguez-Ubreva, Javier

Abstract

In COVID-19, hyperinflammatory and dysregulated immune responses contribute to severity. Patients with pre-existing autoimmune conditions can therefore be at increased risk of severe COVID-19 and/or associated sequelae, yet SARS-CoV-2 infection in this group has been little studied. Here, we performed single-cell analysis of peripheral blood mononuclear cells from patients with three major autoimmune diseases (rheumatoid arthritis, psoriasis, or multiple sclerosis) during SARS-CoV-2 infection. We observed compositional differences between the autoimmune disease groups coupled with altered patterns of gene expression, transcription factor activity, and cell-cell communication that substantially shape the immune response under SARS-CoV-2 infection. While enrichment of HLA-DRlow CD14+ monocytes was observed in all three autoimmune disease groups, type-I interferon signaling as well as inflammatory T cell and monocyte responses varied widely between the three groups of patients. Our results reveal disturbed immune responses to SARS-CoV-2 in patients with pre-existing autoimmunity, highlighting important considerations for disease treatment and follow-up.

Published
2024

45. SARS-CoV-2 interaction with Siglec-1 mediates trans-infection by dendritic cells

Author

Perez-Zsolt, Daniel, Muñoz-Basagoiti, Jordana, Rodon, Jordi, Elosua-Bayes, Marc, Raïch-Regué, Dàlia, Risco, Cristina, Sachse, Martin, Pino, Maria, Gumber, Sanjeev, Paiardini, Mirko, Chojnacki, Jakub, Erkizia, Itziar, Muñiz-Trabudua, Xabier, Ballana, Ester, Riveira-Muñoz, Eva, Noguera-Julian, Marc, Paredes, Roger, Trinité, Benjamin, Tarrés-Freixas, Ferran, Blanco, Ignacio, Guallar, Victor, Carrillo, Jorge, Blanco, Julià, Telenti, Amalio, Heyn, Holger, Segalés, Joaquim, Clotet, Bonaventura, Martinez-Picado, Javier, Vergara-Alert, Júlia, and Izquierdo-Useros, Nuria

Published
2021
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46. Author Correction to: SARS-CoV-2 interaction with Siglec-1 mediates trans-infection by dendritic cells

Author

Perez-Zsolt, Daniel, Muñoz-Basagoiti, Jordana, Rodon, Jordi, Elosua-Bayes, Marc, Raïch-Regué, Dàlia, Risco, Cristina, Sachse, Martin, Pino, Maria, Gumber, Sanjeev, Paiardini, Mirko, Chojnacki, Jakub, Erkizia, Itziar, Muñiz-Trabudua, Xabier, Ballana, Ester, Riveira-Muñoz, Eva, Noguera-Julian, Marc, Paredes, Roger, Trinité, Benjamin, Tarrés-Freixas, Ferran, Blanco, Ignacio, Guallar, Victor, Carrillo, Jorge, Blanco, Julià, Telenti, Amalio, Heyn, Holger, Segalés, Joaquim, Clotet, Bonaventura, Martinez-Picado, Javier, Vergara-Alert, Júlia, and Izquierdo-Useros, Nuria

Published
2022
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47. Production and Immunogenicity of FeLV Gag-Based VLPs Exposing a Stabilized FeLV Envelope Glycoprotein.

Author

Ortiz, Raquel, Barajas, Ana, Pons-Grífols, Anna, Trinité, Benjamin, Tarrés-Freixas, Ferran, Rovirosa, Carla, Urrea, Víctor, Barreiro, Antonio, Gonzalez-Tendero, Anna, Rovira-Rigau, Maria, Cardona, Maria, Ferrer, Laura, Clotet, Bonaventura, Carrillo, Jorge, Aguilar-Gurrieri, Carmen, and Blanco, Julià

Subjects
FELINE leukemia virus, IMMUNE response, GLYCOPROTEINS, HUMORAL immunity, MEMBRANE proteins, DNA vaccines, VIRAL envelope proteins
Abstract

The envelope glycoprotein (Env) of retroviruses, such as the Feline leukemia virus (FeLV), is the main target of neutralizing humoral response, and therefore, a promising vaccine candidate, despite its reported poor immunogenicity. The incorporation of mutations that stabilize analogous proteins from other viruses in their prefusion conformation (e.g., HIV Env, SARS-CoV-2 S, or RSV F glycoproteins) has improved their capability to induce neutralizing protective immune responses. Therefore, we have stabilized the FeLV Env protein following a strategy based on the incorporation of a disulfide bond and an Ile/Pro mutation (SOSIP) previously used to generate soluble HIV Env trimers. We have characterized this SOSIP-FeLV Env in its soluble form and as a transmembrane protein present at high density on the surface of FeLV Gag-based VLPs. Furthermore, we have tested its immunogenicity in DNA-immunization assays in C57BL/6 mice. Low anti-FeLV Env responses were detected in SOSIP-FeLV soluble protein-immunized animals; however, unexpectedly no responses were detected in the animals immunized with SOSIP-FeLV Gag-based VLPs. In contrast, high humoral response against FeLV Gag was observed in the animals immunized with control Gag VLPs lacking SOSIP-FeLV Env, while this response was significantly impaired when the VLPs incorporated SOSIP-FeLV Env. Our data suggest that FeLV Env can be stabilized as a soluble protein and can be expressed in high-density VLPs. However, when formulated as a DNA vaccine, SOSIP-FeLV Env remains poorly immunogenic, a limitation that must be overcome to develop an effective FeLV vaccine. [ABSTRACT FROM AUTHOR]

Published
2024
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50. Novel Spike-stabilized trimers with improved production protect K18-hACE2 mice and golden Syrian hamsters from the highly pathogenic SARS-CoV-2 Beta variant

Author

Ávila-Nieto, Carlos, primary, Vergara-Alert, Júlia, additional, Amengual-Rigo, Pep, additional, Ainsua-Enrich, Erola, additional, Brustolin, Marco, additional, Rodríguez de la Concepción, María Luisa, additional, Pedreño-Lopez, Núria, additional, Rodon, Jordi, additional, Urrea, Victor, additional, Pradenas, Edwards, additional, Marfil, Silvia, additional, Ballana, Ester, additional, Riveira-Muñoz, Eva, additional, Pérez, Mònica, additional, Roca, Núria, additional, Tarrés-Freixas, Ferran, additional, Carabelli, Julieta, additional, Cantero, Guillermo, additional, Pons-Grífols, Anna, additional, Rovirosa, Carla, additional, Aguilar-Gurrieri, Carmen, additional, Ortiz, Raquel, additional, Barajas, Ana, additional, Trinité, Benjamin, additional, Lepore, Rosalba, additional, Muñoz-Basagoiti, Jordana, additional, Perez-Zsolt, Daniel, additional, Izquierdo-Useros, Nuria, additional, Valencia, Alfonso, additional, Blanco, Julià, additional, Clotet, Bonaventura, additional, Guallar, Victor, additional, Segalés, Joaquim, additional, and Carrillo, Jorge, additional

Published
2023
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