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3. Comparison between invasive and noninvasive methods to estimate subendocardial oxygen supply and demand imbalance

Author

Salvi, P, Baldi, C, Scalise, F, Grillo, A, Salvi, L, Tan, I, De Censi, L, Sorropago, A, Moretti, F, Sorropago, G, Gao, L, Rovina, M, Simon, G, Fabris, B, Carretta, R, Avolio, A, Parati, G, Salvi P., Baldi C., Scalise F., Grillo A., Salvi L., Tan I., De Censi L., Sorropago A., Moretti F., Sorropago G., Gao L., Rovina M., Simon G., Fabris B., Carretta R., Avolio A. P., Parati G., Salvi, P, Baldi, C, Scalise, F, Grillo, A, Salvi, L, Tan, I, De Censi, L, Sorropago, A, Moretti, F, Sorropago, G, Gao, L, Rovina, M, Simon, G, Fabris, B, Carretta, R, Avolio, A, Parati, G, Salvi P., Baldi C., Scalise F., Grillo A., Salvi L., Tan I., De Censi L., Sorropago A., Moretti F., Sorropago G., Gao L., Rovina M., Simon G., Fabris B., Carretta R., Avolio A. P., and Parati G.

Abstract

BACKGROUND: Estimation of the balance between subendocardial oxygen supply and demand could be a useful parameter to assess the risk of myocardial ischemia. Evaluation of the subendocardial viability ratio (SEVR, also known as Buckberg index) by invasive recording of left ventricular and aortic pressure curves represents a valid method to estimate the degree of myocardial perfusion relative to left ventricular workload. However, routine clinical use of this parameter requires its noninvasive estimation and the demonstration of its reliability. METHODS AND RESULTS: Arterial applanation tonometry allows a noninvasive estimation of SEVR as the ratio of the areas directly beneath the central aortic pressure curves obtained during diastole (myocardial oxygen supply) and during systole (myocardial oxygen demand). However, this “traditional” method does not account for the intra-ventricular diastolic pressure and proper allocation to systole and diastole of left ventricular isometric contraction and relaxation, respectively, resulting in an overestimation of the SEVR values. These issues are considered in the novel method for SEVR assessment tested in this study. SEVR values estimated with carotid tonometry by "traditional” and "new” method were compared with those evaluated invasively by cardiac catheterization. The “traditional” method provided significantly higher SEVR values than the reference invasive SEVR: average of differences±SD= 44±11% (limits of agreement: 23% – 65%). The noninvasive “new” method showed a much better agreement with the invasive determination of SEVR: average of differences±SD= 0±8% (limits of agreement:-15% to 16%). CONCLUSIONS: Carotid applanation tonometry provides valid noninvasive SEVR values only when all the main factors determining myocardial supply and demand flow are considered.

Published
2021

4. Noninvasive Estimation of Aortic Stiffness Through Different Approaches: Comparison with Intra-Aortic Recordings

Author

Salvi, P, Scalise, F, Rovina, M, Moretti, F, Salvi, L, Grillo, A, Gao, L, Baldi, C, Faini, A, Furlanis, G, Sorropago, A, Millasseau, S, Sorropago, G, Carretta, R, Avolio, A, Parati, G, Salvi P., Scalise F., Rovina M., Moretti F., Salvi L., Grillo A., Gao L., Baldi C., Faini A., Furlanis G., Sorropago A., Millasseau S. C., Sorropago G., Carretta R., Avolio A. P., Parati G., Salvi, P, Scalise, F, Rovina, M, Moretti, F, Salvi, L, Grillo, A, Gao, L, Baldi, C, Faini, A, Furlanis, G, Sorropago, A, Millasseau, S, Sorropago, G, Carretta, R, Avolio, A, Parati, G, Salvi P., Scalise F., Rovina M., Moretti F., Salvi L., Grillo A., Gao L., Baldi C., Faini A., Furlanis G., Sorropago A., Millasseau S. C., Sorropago G., Carretta R., Avolio A. P., and Parati G.

Abstract

Aortic pulse wave velocity is a worldwide accepted index to evaluate aortic stiffness and can be assessed noninvasively by several methods. This study sought to determine if commonly used noninvasive devices can all accurately estimate aortic pulse wave velocity. Pulse wave velocity was estimated in 102 patients (aged 65±13 years) undergoing diagnostic coronary angiography with 7 noninvasive devices and compared with invasive aortic pulse wave velocity. Devices evaluating carotid-femoral pulse wave velocity (Complior Analyse, PulsePen ET, PulsePen ETT, and SphygmoCor) showed a strong agreement between each other (r>0.83) and with invasive aortic pulse wave velocity. The mean difference ±SD with the invasive pulse wave velocity was -0.73±2.83 m/s (r=0.64) for Complior-Analyse: 0.20±2.54 m/s (r=0.71) for PulsePen-ETT: -0.04±2.33 m/s (r=0.78) for PulsePen ET; and -0.61±2.57 m/s (r=0.70) for SphygmoCor. The finger-toe pulse wave velocity, evaluated by pOpmètre, showed only a weak relationship with invasive aortic recording (mean difference ±SD =-0.44±4.44 m/s; r=0.41), and with noninvasive carotid-femoral pulse wave velocity measurements (r<0.33). Pulse wave velocity estimated through a proprietary algorithm by BPLab (v.5.03 and v.6.02) and Mobil-O-Graph showed a weaker agreement with invasive pulse wave velocity compared with carotid-femoral pulse wave velocity (mean difference ±SD =-0.71±3.55 m/s, r=0.23; 1.04±2.27 m/s, r=0.77; and -1.01±2.54 m/s, r=0.71, respectively), revealing a negative proportional bias at Bland-Altman plot. Aortic pulse wave velocity values provided by BPLab and Mobil-O-Graph were entirely dependent on age-squared and peripheral systolic blood pressure (cumulative r2=0.98 and 0.99, respectively). Thus, among the methods evaluated, only those assessing carotid-femoral pulse wave velocity (Complior Analyse, PulsePen ETT, PulsePen ET, and SphygmoCor) appear to be reliable approaches for estimation of aortic stiffness.

Published
2019

6. Ambulatory Arterial Stiffness Indexes in Acromegaly.

Author

Dassie, F, primary, Grillo, A, additional, Carretta, R, additional, Fabris, B, additional, Macaluso, L, additional, Bardelli, M, additional, Martini, C, additional, Vettor, R, additional, Sicolo, N, additional, Fallo, F, additional, and Maffei, P, additional

Published
2010
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9. Influence of carotid atherosclerotic plaques on pulse wave assessment with arterial tonometry

Author

Grillo, A, Simon, G, Salvi, P, Rovina, M, Baldi, C, Prearo, I, Bernardi, S, MENCHINI-FABRIS, G, Faini, A, Parati, G, Bardelli, M, Carretta, R, GRILLO, ANDREA, MENCHINI-FABRIS, GIOVANNI BATTISTA, FAINI, ANDREA, PARATI, GIANFRANCO, Carretta, R., Grillo, A, Simon, G, Salvi, P, Rovina, M, Baldi, C, Prearo, I, Bernardi, S, MENCHINI-FABRIS, G, Faini, A, Parati, G, Bardelli, M, Carretta, R, GRILLO, ANDREA, MENCHINI-FABRIS, GIOVANNI BATTISTA, FAINI, ANDREA, PARATI, GIANFRANCO, and Carretta, R.

Abstract

Objective: Aortic stiffness and central pressure measurements have become increasingly important for the overall estimation of cardiovascular risk. The aim of this study is to verify whether the presence of stenosis in the carotid arteries due to atherosclerotic plaques may induce a bias in the measurement of carotid-femoral pulse wave velocity (PWV) and in the analysis of central pulse waveform variables assessed by carotid tonometry. Methods: Eighty-four patients (age: 67.1 ± 12.4 years) undergoing screening for carotid atherosclerosis were enrolled, divided into three groups according to carotid ultrasound findings (NASCET criteria): 28 patients without significant stenosis, 30 patients with bilateral plaques, and 26 patients with right or left monolateral stenosis. PWV and other variables derived from the central pulse waveform analysis (central blood pressure, augmentation index and forward and backward waves) were measured at both right and left carotid arteries by a validated PulsePen tonometer. A repeatability study was performed in 28 young healthy patients (age: 25.4 ± 2.9 years). Results: A high degree of correlation was found between bilateral measurements in all groups, and particularly in groups with monolateral carotid stenosis, with no significant difference attributable to lateralized stenosis. Right-left differences in asymmetric groups were 0.35 ± 5.12 mmHg (R2 = 0.960) for central blood pressure,-2.12 ± 7.39% (R2 = 0.743) for augmentation index, 0.64 ± 1.56 m/s (R2 = 0.947) for PWV, 0.08 ± 8.48 mmHg for forward wave (R2 = 0.742) and 0.35 ± 2.35 mmHg for backward wave (R2 = 0.907). Conclusion: Measurement of PWV and of variables derived from the central pulse waveform analysis by carotid tonometry is not biased by the presence of local atherosclerotic plaques.

Published
2017

12. Aortic stiffness and pulse wave analysis in children and adolescents with marfan syndrome

Author

Grillo, A, Pini, A, Gao, L, Trifirò, G, Marelli, S, Viecca, F, Salvi, L, Salvi, P, Rovina, M, Carretta, R, Parati, G, Grillo, A, Pini, A, Gao, L, Trifirò, G, Marelli, S, Viecca, F, Salvi, L, Salvi, P, Rovina, M, Carretta, R, and Parati, G

Subjects
aortic stiffness
Abstract

OBJECTIVE: Marfan syndrome (MFS) is an autosomal dominant genetic disorder characterized by aortic root dilation beginning in childhood. Aortic stiffness is increased in patients with MFS but data in pediatric age are lacking. Aim of this study was to evaluate aortic stiffness and pulse wave analysis in children and adolescents with MFS, compared to general pediatric population, and its association with aortic root diameters. DESIGN AND METHOD: Fifty-two children with MFS (age: 12.0 ± 3.3, 5.6-17.5 years), identified according to 2010 Revised Ghent Criteria and without history of cardiovascular surgery were enrolled. Patients underwent a clinical evaluation and an echocardiography. Viscoelastic aortic properties were studied assessing carotid-femoral pulse wave velocity (PWV) and analysing central blood pressure waveform with carotid tonometry. Hemodynamic parameters of MFS patients were compared with those of 73 age, sex, mean blood pressure and heart rate matched controls. RESULTS: Central pulse pressure (CPP) was significantly higher (38.2 ± 12.2 vs 33.6 ± 8.0 mmHg, p = 0.01) and pulse pressure amplification (PPA) was significantly reduced in MFS patients than controls (18.0 ± 15.1% vs 31.8 ± 20.3%, p

Published
2016

13. Systolic time intervals assessed from analysis of the carotid pressure waveform

Author

Salvi, P, Grillo, A, Tan, I, Simon, G, Salvi, L, Gao, L, Rovina, M, Butlin, M, Yang, Y, Meneghin, E, Meng, L, Faini, A, Barin, E, Pini, A, Carretta, R, Huo, Y, Avolio, A, Parati, G, Salvi, Paolo, Grillo, Andrea, Tan, Isabella, Simon, Giulia, Salvi, Lucia, GAO, LAN, Rovina, Matteo, Butlin, Mark, Yang, Ying, Meneghin, Erika, Meng, Lei, Faini, Andrea, Barin, Edward, Pini, Alessandro, Carretta, Renzo, Huo, Yong, Avolio, Alberto, Parati, Gianfranco, Salvi, P, Grillo, A, Tan, I, Simon, G, Salvi, L, Gao, L, Rovina, M, Butlin, M, Yang, Y, Meneghin, E, Meng, L, Faini, A, Barin, E, Pini, A, Carretta, R, Huo, Y, Avolio, A, Parati, G, Salvi, Paolo, Grillo, Andrea, Tan, Isabella, Simon, Giulia, Salvi, Lucia, GAO, LAN, Rovina, Matteo, Butlin, Mark, Yang, Ying, Meneghin, Erika, Meng, Lei, Faini, Andrea, Barin, Edward, Pini, Alessandro, Carretta, Renzo, Huo, Yong, Avolio, Alberto, and Parati, Gianfranco

Abstract

The timing of mechanical cardiac events is usually evaluated by conventional echocardiography as an index of cardiac systolic function and predictor of cardiovascular outcomes. We aimed to measure the systolic time intervals, namely the isovolumetric contraction time (ICT) and pre-ejection period (PEP), by arterial tonometry.

Published
2018

19. NON-INVASIVE MEASUREMENT OF AORTIC PULSE WAVE VELOCITY

Author

Grillo, A., primary, Moretti, F., additional, Rovina, M., additional, Baldi, C., additional, Salvi, L., additional, Gao, L., additional, Scalise, F., additional, Sorropago, G., additional, Faini, A., additional, Millasseau, S., additional, Salvi, P., additional, Carretta, R., additional, and Parati, G., additional

Published
2018
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30. AMLODIPINE IN PATIENTS WITH MILD TO MODERATE HYPERTENSION

Author

Palatini P, Malacco E, Fogari R, Carretta R, Bertocchi F, Mann J, BONADUCE, DOMENICO, CONDORELLI, MARIO, Palatini, P, Malacco, E, Fogari, R, Carretta, R, Bonaduce, Domenico, Bertocchi, F, Mann, J, and Condorelli, Mario

Published
2001

32. PP.09.26

Author

Grillo, A., primary, Bernardi, S., additional, Rebellato, A., additional, Fabris, B., additional, Bardelli, M., additional, Burrello, J., additional, Rabbia, F., additional, Veglio, F., additional, Fallo, F., additional, and Carretta, R., additional

Published
2015
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33. 5B.05

Author

Grillo, A., primary, Pini, A., additional, Marelli, S., additional, Gan, L., additional, Giuliano, A., additional, Trifirò, G., additional, Santini, F., additional, Salvi, L., additional, Salvi, P., additional, Viecca, F., additional, Carretta, R., additional, and Parati, G., additional

Published
2015
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34. 2D.02

Author

Salvi, L., primary, Grillo, A., additional, Marelli, S., additional, Gao, L., additional, Giuliano, A., additional, Trifirò, G., additional, Santini, F., additional, Pini, A., additional, Salvi, P., additional, Viecca, F., additional, Carretta, R., additional, and Parati, G., additional

Published
2015
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36. Identifying patients at risk for microalbuminuria via interaction of the components of the metabolic syndrome: a cross-sectional analytic study

Author

Gentile, L., Cichero, P., Di Berardino, P., Di Petta, C., Montani, V., Poli, M., Grosso, J., De Marco, F., Perticone, F., Mattace, A., Vatrano, M., Ventura, G., Sprovieri, M., Spagnuolo, V., Mastropasqua, A., Marenco, P., Caruso, M., D’Ugo, E., Squadrone, M. R., Pupillo, M., Minnucci, A., De Luca, A., Tagliaferri, M., Vitale, C., Sciangula, L., Banfi, E., Cucinotta, D., Dibenedetto, A., Previti, M., Tiengo, A., Avogaro, A., Bettio, M., Dekreuzenberg, S., Galluzzo, A., Camilleri, C., Merlino, S., Sinagra, D., Provenzano, V., Fleres, M., Carnovali, M., Crespi, E., Sommariva, M., Vecchio, C., Consoli, A., Ciccarone, E., Devangelio, E., Formoso, G., Taraborrelli, M., Seghieri, G., Alviggi, L., Bardini, G., De Bellis, A., Porro, T., Bianchi, A., Dagani, R., Di Battista, R., Ferrario, A., Ottaviano, R., Gambardella, S., Bracaglia, D., Testa, G., Mancini, A., Giannini, D., Monesi, G., Mollo, F., Osti, M., Di Michele, D., Lattanzi, E., Piersanti, C., Ghigo, E., Camanni, F., Destefanis, S., Gaia, D., Gasco, V., Maccario, M., Carretta, R., Fiammengo, F., Gerloni, R., Macaluso, L., Donnini, P., Alvaro, S., Ambrosio, G. B., Leprotti, C., Moro, E., Pais, M., Pianetti, S., Garbin, A., Frascone, V., Marmo, P., Munari, G. F., Cataldi, B., Filiani, M. L., Ursini, G., Augello, M., Tassan, P., Giraldi, D., Berarducci, G., Braggion, M., Novelletto, B. F., Dell’Orco, R. L., Baj, A., Pardo, S., Persia, M., Bellini, F., Nistico, F., Rossi, C. L., Quinzii, G., Ferrigato, A., Zaramella, M. L., Crisante, E., Biundo, G., Serughetti, G., Sofra, D., Trono, L., Arduino, G., Chiappetta, S., Novarese, I., Monari, M., Cappello, I., Lipari, L., Bersani, G. P., Marcomini, G., Felici, M. G., Bragiotto, A., Felice, L., Caberletti, I., Vergani, P., Orecchia, E., Ferracin, F., Cavallo, G., Giardina, L., Felloni, L., Cesarone, L., Albanese, V., Bizzozero, L., Cerati, C., Mauri, L., Ratti, C., Alecci, U., Alibrando, A., Forastiere, G., Petrella, G., Di Mattia, Q., Grimaldi, N., Olivieri, I., Cardella, M. C., Duren, B., Falzone, A., Furlan, G., Nesladek, N., Novel, N., Pasquariello, M., Russo, M., Veglia, D., Fusello, M., Baldi, C., Seller, R., Tosi, G., Barberio, S., Tonon, R., Cardinale, G., Lombardo, F. P., Magliozzo, F., Merlino, G., Merlino, N., Quartetti, G., Bolognese, F., Baglieri, S., Giarrusso, P., Speciale, S., Buffone, M., Di Domizio, O., Panzieri, F., Perfetto, G., Granati, A., Lattari, P. R., Potenti, P. G., Quattrocchi, M., Vannucci, R., Daddi, L., Dallatorre, G., Guido, G. P., Orlando, F., Santoro, A., Zagni, R., Genova, O., Alaimo, A., Canfora, M., Cappelli, C., Caracciolo, F., Casimirri, R., Crestini, A. M., Daniele, G., De Lucia, L., Demarchis, A., Di Masi, A., Di Rosa, F., Filabozzi, A., Levati, M., Lucente, A., Manzo, G., Marchionne, M., Marino, G. A., Paolini, E., Quaresima, M., Scala, P., Scotto, M., Scotto, R., Simeoni, A., Chieregato, G., Sparesato, S., Cavallo, E., Ceglia, G., Chiarini, T., Visentini, E., Sammarone, R., Di Giambattista, P., Fumagalli, M. A., Milanese, F., Santoro, L., Giusti, P., Nafra, G., Romito, G., Balsamo, R., Rinaldi, M., Biondo, F., Consiglio, G., Arbore, G., Garione, I., Merlini, C., Pizzini, A., Titta, G., Vitali, S., Rotondo, G., Berardi, A., Castellani, G., Cova, L. V., Lamberti, C., Granzotto, S., Mazzi, P. A., Bergamasco, G., Autiero, V., and L. Ghiraldelli.

Subjects
Male, medicine.medical_specialty, Multivariate analysis, endocrine system diseases, Epidemiology, Population, urologic and male genital diseases, Critical Care and Intensive Care Medicine, Impaired glucose tolerance, Insulin resistance, Risk Factors, Diabetes mellitus, Internal medicine, medicine, Albuminuria, Humans, education, Aged, Metabolic Syndrome, Transplantation, education.field_of_study, business.industry, nutritional and metabolic diseases, Middle Aged, medicine.disease, female genital diseases and pregnancy complications, Endocrinology, Cross-Sectional Studies, Nephrology, Homogeneous, Microalbuminuria, Female, Metabolic syndrome, business
Abstract

The objective of this study was to investigate correlates of risk for having microalbuminuria in individuals with one or more cardiovascular risk factors.The study involved 1919 individuals who attended general practice settings, were aged 55 to 75 yr, and did not have a history of cardiovascular events or diabetes but had one or more cardiovascular risk factors. A tree-based regression technique and multivariate analysis were used to identify distinct, homogeneous subgroups of patients with different likelihood of having microalbuminuria; interaction between correlates of microalbuminuria and risk for microalbuminuria was also investigated.The prevalence of microalbuminuria was 5.9%. Patients who did not have hypertension and had postload glycemia140 mg/dl showed the lowest prevalence of microalbuminuria (1.9%) and represented the reference class. The likelihood of microalbuminuria was seven times higher in men with hypertension and homeostatic model assessment levels in the upper tertile and four times higher in women with the same characteristics. Individuals with hypertension and lower homeostatic model assessment levels and normotensive individuals with postload glycemiaor = 140 mg/dl had a more than three-fold increased likelihood of having microalbuminuria. Treatment with statins was associated with a 54% reduction in the likelihood of having microalbuminuria, whereas levels of triglycerides150 mg/dl and fibrinogen levels in the upper tertile were associated with a significantly higher risk for microalbuminuria.The likelihood of having microalbuminuria in a population-based study of elderly individuals is strongly related to the interaction between the components of the metabolic syndrome, particularly hypertension, insulin resistance, and impaired glucose tolerance.

Published
2007

37. Use of the Diabetes Risk Score for Opportunistic Screening of Undiagnosed Diabetes and Impaired Glucose Tolerance: The IGLOO (Impaired Glucose Tolerance and Long-Term Outcomes Observational) study

Author

Muggeo, M., Caimi, V., Capani, F., Cucinotta, D., Grimaldi, N., Montanari, P., Mocarelli, P., Signorini, S., Dinardo, B., Ferrari, S., Piaggione, M., Gentile, L., Cichero, P., Di Berardino, P., Di Petta, C., Montani, V., Poli, M., Grosso, J., De Marco, F., Perticone, F., Mattace, A., Vatrano, M., Ventura, G., Sprovieri, M., Spagnuolo, V., Mastropasqua, A., Marenco, P., D’Ugo, E., Squadrone, M. R., Pupillo, M., De Luca, A., Mennucci, A., Tagliaferri, M., Vitale, C., Sciangula, L., Banfi, E., Di Benedetto, A., Previti, M., Tiengo, A., Avogaro, A., Bettio, De Kreuzenberg, S., Galluzzo, A., Camilleri, C., Merlino, S., Sinagra, D., Provenzano, V., Fleres, M., Spano, L., Carnovali, M., Crespi, E., Sommariva, M., Vecchio, C., Consoli, A., Ciccarone, E., Devangelio, E., Formoso, G., Seghieri, G., Alviggi, L., Bardini, G., De Bellis, A., Porro, T., Bianchi, A., Dagani, R., Di Battista, R., Ferrario, Gambardella, S., Bracaglia, D., Testa, G., Giannini, D., Mancini, A., Monesi, G., Mollo, F., Osti, M., Di Michele, D., Lattanzi, E., Piersanti, C., Ghigo, E., Camanni, F., Destefanis, S., Gaia, D., Gasco, V., Maccario, M., Carretta, R., Fiammengo, F., Gerloni, R., Macaluso, L., Donnini, P., Alvaro, S., Ambrosio, G. B., Leprotti, C., Moro, E., Pais, M., Pianetti, S., Garbin, A., Frascone, V., Marmo, P., Munari, G. F., Cataldi, B., Ursini, G., Augello, M., Braggion, M., Baj, A., Persia, M., Nistico’, F., Rossi, C. L., Quinzii, G., Ferrigato, A., Zaramella, M. L., Serughetti, G., Sofra, D., Arduino, G., Chiappetta, S., Novarese, I., Monari, M., Cappello, I., Lipari, L., Marcomini, G., Felice, L., Caberletti, I., Vergani, P., Orecchia, E., Ferracin, F., Cavallo, G., Giardina, L., Felloni, L., Cesarone, L., Bizzozero, L., Ratti, C., Alecci, U., Marino, S., Forastiere, G., Petrella, G., Olivieri, I., Cardella, M. C., Duren, B., Furlan, G., Novel, N., Pasquariello, M., Russo, M., Baldi, C., Seller, R., Tosi, G., Barberio, S., Cardinale, G., Lombardo, F. P., Magliozzo, F., Merlino, G., Merlino, N., Quartetti, G., Bolognese, F., Baglieri, S., Speciale, S., Buffone, M., Di Domizio, O., Panzieri, F., Perfetto, G., Potenti, P. G., Quattrocchi, M., Vannucci, R., Daddi, L., Guido, G. P., Orlando, F., Santoro, A., Zagni, R., Canfora, M., Cappelli, C., Caracciolo, F., Casimirri, R., Crestini, A. M., De Marchis, A., Di Masi, A., Lucente, A., Manzo, G., Marchionne, M., Marino, G. A., Paolini, E., Scala, P., Scotto, M., Scotto, R., Simeoni, A., Chieregato, G., Cavallo, E., Ceglia, G., Chiarini, T., Visentini, E., Sammarone, R., Fumagalli, M. A., Milanese, F., Giusti, P., Balsamo, R., Rinaldi, M., Biondo, F., Consiglio, G., Garione, I., Merlini, C., Pizzini, A., Titta, G., Vitali, S., Rotondo, G., Cova, L. V., Lamberti, C., Granzotto, S., Mazzi, P. A., and Ghiraldelli, L.

Published
2005

40. Comparison of benazepril-amlodipine and captopril-thiazide combinations in the management of mild-to-moderate hypertension

Author

Malacco, E., Piazza, S., Carretta, R., DI SOMMA, Salvatore, Mugellini, A., Bertocchi, F., Palatini, P., and Pressure, I. B.

Subjects
combination, Male, calcium channel blockers, administration /&/ dosage/adverse effects/therapeutic use, Captopril, essential hypertension, Administration, Oral, Benzazepines, Middle Aged, ace inhibitors, administration, aged, amlodipine, antihypertensive agents, benzazepines, captopril, combination therapy, double-blind method, drug administration schedule, drug therapy, female, humans, hydrochlorothiazide, hypertension, male, middle aged, oral, Drug Administration Schedule, Hydrochlorothiazide, Double-Blind Method, Hypertension, Humans, Drug Therapy, Combination, Female, Amlodipine, Antihypertensive Agents, Aged
Abstract

To compare the efficacy and tolerability of benazepril 10 mg + amlodipine 5 mg combination (BZ+AM) versus captopril 50 mg + hydrochlorothiazide 25 mg (CP+HT) combination.405 outpatients with mild-to-moderate arterial hypertension not adequately controlled by a monotherapy with ACE inhibitors or calcium channel blockers or diuretics entered this multicenter, double-blind, randomized, parallel-group study.After a 2-week placebo run-in, 397 patients with sitting diastolic (D) blood pressure (BP)95 mmHg and/or sitting systolic (S) BP160 mmHg were randomized to receive either BZ+AM (201 patients) or CP+HT (196 patients) once daily for 12 weeks. Main outcome measure was sitting DBP and SBP values at the end of active treatment. The response rate was defined as the proportion of patients with either a final sitting DBP90 mmHg or decreased by at least 10 mmHg or a sitting SBP150 mmHg or decreased by at least 20 mmHg from baseline.The DBP and SBP values obtained with BZ+AM were, respectively, 2.7 and 3.7 mmHg lower than those obtained with CP+HT (both p0.001 vs. CP+HT). The response rate in the BZ+AM group (94.8%) was better than that observed in the CP+HT group (86.0%, p = 0.004). The incidence of adverse events was similar with the 2 treatment regimens (17.9% for both).These data suggest a higher antihypertensive efficacy of the fixed combination BZ 10 mg+AM 5 mg as compared with CP 50 mg+HT 25 mg.

Published
2002

42. Central hemodynamics during bladder distension and micturition in healthy volunteers

Author

Fiammengo, F., Gerloni, R., Siracusano, S., Fabris, B., Moreno, Bardelli, Fazio, M., Macaluso, L., Bossi, M., Carretta, R., Campanacci, L., F., Fiammengo, R., Gerloni, Siracusano, Salvatore, B., Fabri, Bardelli, Moreno, M., Fazio, L., Macaluso, M., Bossi, Carretta, Renzo, and L., Campanacci

Subjects
bladder-distension, hemodynamics, hemodynamic
Published
2002

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