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7. Ocular inflammatory events following COVID-19 vaccination: a multinational case series

Author

Testi, I., Brandao-de-Resende, C., Agrawal, R., Pavesio, C., Steeples, L., Balasubramaniam, B., Mccluskey, P., Pichi, F., Agarwal, A., Herbort, C., Cimino, L., Iriqat, S., Thorne, J. E., Echegaray, J., Babu, K., Bialasiewicz, A. A., Goldstein, D. A., Ghadiri, N., Calduch, A. F., Andrade, G. C., Mahendradas, P., Gonzalez-Lopez, J. J., Carreno, E., Hamam, R. N., Stubiger, N., Bodaghi, B., Chao, Y. -J., Takeuchi, M., Tay-Kearney, M. -L., Portero, A., Keino, H., Esteban-Ortega, M., Przezdziecka-Dolyk, J., Radosavljevic, A., Paredes, I., Ling, H. S., Kiong, W., Tien, M., X. L., Ng, Chee, S. P., Siak, J., Hernanz-Rodriguez, I., Menezo, V., Tappeiner, C., Cruz, F. M., Addison, P., Kuijpers, R., Vasconcelos-Santos, D. V., Lee Kong Chian School of Medicine (LKCMedicine), Tan Tock Seng Hospital, Singapore Eye Research Institute, Duke NUS Medical School, Surgical clinical sciences, and Ophtalmology - Eye surgery

Subjects
Immunomodulatory, SARS-CoV-2, Vaccination, Ocular inflammation, COVID-19, RE1-994, vaccination, infectious diseases, Coronavirus disease, Uveitis, Ophthalmology, Medicine [Science], Ocular Inflammation, Original Research
Abstract

Background Inflammatory adverse events following COVID-19 vaccination are being reported amidst the growing concerns regarding vaccine’s immunogenicity and safety, especially in patients with pre-existing inflammatory conditions. Methods Multinational case series of patients diagnosed with an ocular inflammatory event within 14 days following COVID-19 vaccination collected from 40 centres over a 3 month period in 2021. Results Seventy patients presented with ocular inflammatory events within 14 days following COVID-19 vaccination. The mean age was 51 years (range, 19–84 years). The most common events were anterior uveitis (n = 41, 58.6%), followed by posterior uveitis (n = 9, 12.9%) and scleritis (n = 7, 10.0%). The mean time to event was 5 days and 6 days (range, 1–14 days) after the first and second dose of vaccine, respectively. Among all patients, 36 (54.1%) had a previous history of ocular inflammatory event. Most patients (n = 48, 68.6%) were managed with topical corticosteroids. Final vision was not affected in 65 (92.9%), whereas 2 (2.9%) and 3 (4.3%) had reduction in visual acuity reduced by ≤3 lines and > 3 lines, respectively. Reported complications included nummular corneal lesions (n = 1, 1.4%), cystoid macular oedema (n = 2, 2.9%) and macular scarring (n = 2, 2.9%). Conclusion Ocular inflammatory events may occur after COVID-19 vaccination. The findings are based on a temporal association that does not prove causality. Even in the possibility of a causal association, most of the events were mild and had a good visual outcome.

Published
2022

8. Systematic approach to generate Historical Building Information Modelling (HBIM) in architectural restoration project

Author

Moyano, J, Carreno, E, Nieto-Julian, Je, Gil-Arizon, I, Bruno, S, Universidad de Sevilla. Departamento de Expresión Gráfica e Ingeniería en la Edificación, and Universidad de Sevilla. TEP970: Innovación Tecnológica, Sistemas de Modelado 3d y Diagnosis Energética en Patrimonio y Edificación

Subjects
Parametric objects, HBIM, Revit, Control and Systems Engineering, Restoration project, Digital twin, Building and Construction, Civil and Structural Engineering
Abstract

Working with heritage is complex and projects often include scientific, structural, and documentary studies. Every step requires a systematic approach in which the contribution of the diverse experts that participate in the conservation of heritage assets is analysed following the logical sequence of the project execution phase. However, there are still no scientific contributions that record the complete process. A logical sequence, called a ‘systematic approach’ in this paper, should start with data acquisition using remote sensing techniques, the insertion of point cloud data in a Building Information Modelling (BIM) environment, ontologies applied to HBIM (Historic BIM), data classification, and evolution towards the Digital Twin (DT) concept. This paper also analyses the modelling workflow of a case study, the construction of a column base of the Santiago church in Jerez de la Frontera (Spain). This component has been automatically modelled from a mesh in an Autodesk Revit family and through an adaptive mesh process in ArchiCAD. Furthermore, one of the objectives was the data organisation by following and extending a standard data structure of the column components. This paper presents a novel holistic approach from data capture, analysis of complex geometry, construction of the semantically enriched parametric model, and exchange of it among all involved professionals in open source IFC formats. This systematic approach therefore makes it possible to obtain a validated DT for the life-cycle management of architectural elements.

Published
2022
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11. Baseline characteristics of patients with Usher Syndrome due to MYO7A mutations enrolled in a prospective natural history study

Author

Testa F, Carreno E, Vermeer K, Di Lorio V, Jimenez-Rolando B, Karali M, Sandoval BG, Romero IP, Salvador JM, Melillo P, Banfi S, Auricchio A, van den Born LI, Ayuso C, Simonelli F, Testa, F, Carreno, E, Vermeer, K, Di Lorio, V, Jimenez-Rolando, B, Karali, M, Sandoval, Bg, Romero, Ip, Salvador, Jm, Melillo, P, Banfi, S, Auricchio, A, van den Born, Li, Ayuso, C, and Simonelli, F

Subjects
genetic structures, eye diseases
Abstract

Purpose : Natural history data of Usher Syndrome (USH) due to MYO7A mutations are scarce. In view of future gene therapy studies, we assessed the natural course and investigated potential clinical endpoints in patients with USH due to MYO7A mutations. Methods : a multicenter prospective longitudinal (two-year) natural history study was designed within Ushther project (www.ushther.eu/). Patients aged 8 years or older with USH due to MYO7A mutations and a visual acuity ≥ 20/640 in at least one eye were recruited. We assessed: best-corrected visual acuity (BCVA, ETDRS), kinetic Visual field (VF, Octopus 900), spectral domain optical coherence tomography (OCT), microperimetry (MP, MAIA), and full-field electroretinogram (ERG). Regression analysis on baseline data was performed to estimate progression with age. Results : Forty-four patients aged 9-72 years (34.7 ± 16.1 years) were enrolled at the 3 centers. At baseline, patients showed a reduced BCVA (0.47 ± 0.30 logMAR in RE; 0.43 ± 0.32 logMAR in LE) and a constricted visual field (using V4e stimulus size: 5,436°2 ± 878°2 in RE; 5,722°2 ± 903°2 in LE). Moreover, MP showed a reduced macular sensitivity (8.2 ± 1.7 dB in RE; 8.2 ± 1.7 in LE). From preliminary analysis of OCT scans, we observed a disrupted Ellipsoid Zone (EZ) band with a mean width of 1,880 ± 329 µm in RE and of 1,842 ± 307 µm in LE. ERG responses were below noise level in all patients but five who showed markedly reduced responses in a rod-cone pattern. Cross-sectional analysis showed a decline with age of the BCVA (at a mean annual rate of 0.015 logMAR/year equivalent to about 1 EDTRS letter / year; P

Published
2020

12. Collaborative Ocular Tuberculosis Study Consensus Guidelines on the Management of Tubercular Uveitis—Report 2: Guidelines for Initiating Antitubercular Therapy in Anterior Uveitis, Intermediate Uveitis, Panuveitis, and Retinal Vasculitis

Author

Agrawal, R., Testi, I., Bodaghi, B., Barisani-Asenbauer, T., Mccluskey, P., Agarwal, A., Kempen, J. H., Gupta, A., Smith, J. R., de Smet, M. D., Yuen, Y. S., Mahajan, S., Kon, O. M., Nguyen, Q. D., Pavesio, C., Gupta, V., Agarwal, M., Aggarwal, A., Aggarwal, K., Agrawal, M., Al-Dhibi, H., Androudi, S., Asyari, F., Balasundaram, M. B., Murthy, K. B., Baglivo, E., Banker, A., Bansal, R., Basu, S., Behera, D., Biswas, J., Carreno, E., Caspers, L., Chee, S. P., Chhabra, R., Cimino, L., Concha del Rio, L. E., Cunningham, E. T., Land Curi, A. L., Das, D., Davis, J., Desmet, M., Denisova, E., Denniston, A. K., Errera, M. -H., Fonollosa, A., George, A., Goldstein, D. A., Crosier, Y. G., Gunasekeran, D. V., Gurbaxani, A., Invernizzi, A., Isa, H. M., Islam, S. M. D., Jones, N., Katoch, D., Khairallah, M., Khosla, A., Kramer, M., Kumar, A., La Distia Nora, R., Lee, R., Lowder, C., Luthra, S., Mahendradas, P., Makhoul, D., Mazumdar, S., Mehta, S., Miserocchi, E., Mochizuki, M., Mohamed, O. S., Muccioli, C., Munk, M. R., Murthy, S., Narain, S., Nascimento, H., Neri, P., Nguyen, M., Okada, A. A., Ozdal, P., Palestine, A., Pichi, F., Raje, D., Rathinam, S. R., Rousselot, A., Schlaen, A., Sehgal, S., Nida Sen, H., Sharma, A., Sharma, K., Shoughy, S. S., Singh, N., Singh, R., Soheilian, M., Sridharan, S., Thorne, J. E., Tappeiner, C., Teoh, S., Tognon, M. S., Tugal-Tutkun, I., Tyagi, M., Uy, H., Vasconcelos Santos, D. V., Valentincic, N. V., Westcott, M., Yanai, R., Alvarez, B. Y., Zahedur, R., Zierhut, M., and Xian, Z.

Published
2021

13. Genetic landscape of 6089 inherited retinal dystrophies affected cases in Spain and their therapeutic and extended epidemiological implications (vol 11, pg 1526, 2021)

Author

Perea-Romero, I, Gordo, G, Iancu, IF, Del Pozo-Valero, M, Almoguera, B, Blanco-Kelly, F, Carreno, E, Jimenez-Rolando, B, Lopez-Rodriguez, R, Lorda-Sanchez, I, Martin-Merida, I, de Ayala, LP, Riveiro-Alvarez, R, Rodriguez-Pinilla, E, Tahsin-Swafiri, S, Trujillo-Tiebas, MJ, Garcia-Sandoval, B, Minguez, P, Avila-Fernandez, A, Corton, M, Ayuso, C, Berna S., Allikmets R., Roselló N., and Villota Deleu, Eva

Published
2021

14. Collaborative Ocular Tuberculosis Study Consensus Guidelines on the Management of Tubercular Uveitis—Report 1: Guidelines for Initiating Antitubercular Therapy in Tubercular Choroiditis

Author

Agrawal, R., Testi, I., Mahajan, S., Yuen, Y. S., Agarwal, A., Kon, O. M., Barisani-Asenbauer, T., Kempen, J. H., Gupta, A., Jabs, D. A., Smith, J. R., Nguyen, Q. D., Pavesio, C., Gupta, V., Agarwal, M., Aggarwal, A., Aggarwal, K., Agrawal, M., Al-Dhibi, H., Androudi, S., Asyari, F., Balasundaram, M. B., Murthy, K. B., Baglivo, E., Banker, A., Bansal, R., Basu, S., Behera, D., Biswas, J., Bodaghi, B., Carreno, E., Caspers, L., Chee, S. P., Chhabra, R., Cimino, L., Concha del Rio, L. E., Cunningham, E. T., Land Curi, A. L., Das, D., Davis, J., Desmet, M., Denisova, E., Denniston, A. K., Errera, M. -H., Fonollosa, A., George, A., Goldstein, D. A., Crosier, Y. G., Gunasekeran, D. V., Gurbaxani, A., Invernizzi, A., Isa, H. M., Islam, S. M., Jones, N., Katoch, D., Khairallah, M., Khosla, A., Kramer, M., Kumar, A., La Distia Nora, R., Lee, R., Lowder, C., Luthra, S., Mahendradas, P., Makhoul, D., Mazumdar, S., Mccluskey, P., Mehta, S., Miserocchi, E., Mochizuki, M., Mohamed, O. S., Muccioli, C., Munk, M. R., Murthy, S., Narain, S., Nascimento, H., Neri, P., Nguyen, M., Okada, A. A., Ozdal, P., Palestine, A., Pichi, F., Raje, D., Rathinam, S. R., Rousselot, A., Schlaen, A., Sehgal, S., Sen, H. N., Sharma, A., Sharma, K., Shoughy, S. S., Singh, N., Singh, R., Soheilian, M., Sridharan, S., Thorne, J. E., Tappeiner, C., Teoh, S., Tognon, M. S., Tugal-Tutkun, I., Tyagi, M., Uy, H., Vasconcelos Santos, D. V., Valentincic, N. V., Westcott, M., Yanai, R., Alvarez, B. Y., Zahedur, R., and Zierhut, M.

Published
2021

19. Guidance on Noncorticosteroid Systemic Immunomodulatory Therapy in Noninfectious Uveitis: Fundamentals Of Care for UveitiS (FOCUS) Initiative

Author

Dick, A. D., Rosenbaum, J. T., Al-Dhibi, H. A., Belfort, R., Brezin, A. P., Chee, S. P., Davis, J. L., Ramanan, A. V., Sonoda, K. -H., Carreno, E., Nascimento, H., Salah, S., Salek, S., Siak, J., Steeples, L., Accorinti, M., Acharya, N., Adan, A., Agrawal, R., Akkoc, N., Al Ghamdi, S., Al Ghamdi, T., Al Saati, A., Alsabaani, N., Al-Shamarani, M., Bachta, A., Barisani-Asenbauer, T., Beare, N., Porto, F. B. O., Blanco, R., Yee, A. C. S., Chandran, V., Chiquet, C., Chng, H. H., Cimbalas, A., Cimino, L., Cordero-Coma, M., Cristobal, C., Cuevas, M., Eurico da Fonseca, J., de Boer, J., de la Torre, A., De Schryver, I., Derzko-Dzulynsky, L., Diaz-Valle, D., Merino, C. E. D., Facsko, A., Figueira, L., Fonollosa, A., Fortin, E., Gale, R., Galeazzi, M., Garcia, S., Garcia Ruiz de Morales, J. M., Gaspersic, N., Goldstein, D., Guedes, M., Guex-Crosier, Y., Gul, A., Hamam, R., Haroon, M., Hasegawa, K., Heiligenhaus, A., Hooper, C., Hwang, Y. -S., Hwang, D. -K., Juanola, X., Kaburaki, T., Kadayifcilar, S., Kempen, J., Kezuka, T., Kherani, A., Kirsimae, M., Kotaniemi, K., Kraut, A., Kubicka-Trzaska, A., Kuffova, L., Lightman, S., Lim, L., Lim, W. K., Mccluskey, P., Mcguire, M., Mirabelli, P., Miserocchi, E., Misiuk-Hojlo, M., Muccioli, C., Munoz, S., Murphy, C., Murray, P., Nagy, Z., Namba, K., Neri, P., Nguyen, Q., O'Gradaigh, D., Omair, M., Otsa, K., Ozyazgan, Y., Pablo, F., Paroli, M. P., Pleyer, U., Poor, G., Proenca, R., Rabinovitch, T., Read, R., Rebrov, M., Recillas-Gispert, C., Rothova, A., Schwartzman, S., Seve, P., Sharma, S., Sims, J., Sohar, N., Suhler, E., Szanto, S., Szepessy, Z., Tappeiner, C., Thorne, J., Tugal Tutkun, I., Turno-Krecicka, A., Van Calster, J., van der Horst-Bruinsma, I., Vidovic Valentincic, N., Vitale, A., Voorduin Ramos, S., Vukojevic, N., Wakefield, D., Willermain, F., Yalcindag, N., Yamamoto, J. H., Yeh, S., Zemaitiene, R., and Ziouzina, O.

Published
2018

20. La correction du taux plasmatique de 25-OH vitamine D des patients hémodialysés par la supplémentation en cholécalciférol améliore-t-elle la force musculaire ? Étude VITADIAL : rationnel et protocole

Author

Bataille, S., primary, Pedinielli, N., additional, Carreno, E., additional, Reydit, M., additional, Jean, G., additional, Cavaillé, G., additional, Seret, G., additional, Gentile, S., additional, Jouve, E., additional, and Serveaux, M., additional

Published
2018
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22. Evidence for Tocilizumab as a Treatment Option in Refractory Uveitis Associated with Juvenile Idiopathic Arthritis

Author

Tappeiner C, Mesquida M, Adán A, Anton-Lopez J, Ramanan AV, Carreno E, Mackensen F, Kotaniemi K, de Boer JH, Bou-Torrent R, García de Vicuña-Muñoz C, and Heiligenhaus A

Subjects
musculoskeletal diseases, skin and connective tissue diseases, BIOLOGICS, CYSTOID MACULAR EDEMA, JUVENILE IDIOPATHIC ARTHRITIS, TOCILIZUMAB, UVEITIS
Abstract

To report on experience using the anti-interleukin 6 receptor antibody tocilizumab (TCZ) to treat severe and therapy-refractory uveitis associated with juvenile idiopathic arthritis (JIA).

Published
2016

24. Clinical Features and Outcomes of Patients With Tubercular Uveitis Treated With Antitubercular Therapy in the Collaborative Ocular Tuberculosis Study (COTS)–1

Author

Agrawal, R., Gunasekeran, D. V., Grant, R., Agarwal, A., Kon, O. M., Nguyen, Q. D., Pavesio, C., Gupta, V., Gupta, B., Aggarwal, K., Murthy, S. L., Westcott, M., Phaik, C. S., Mccluskey, P., Ling, H. S., Teoh, S., Cimino, L., Biswas, J., Narain, S., Agarwal, M., Mahendradas, P., Khairallah, M., Jones, N., Tugal-Tutkun, I., Babu, K., Basu, S., Carreno, E., Lee, R., Al-Dhibi, H., Bodaghi, B., Invernizzi, A., Goldstein, D. A., Herbort, C. P., Barisani, T., Gonzalez-Lopez, J. J., Androudi, S., Bansal, R., Moharana, B., Mahajan, S., Esposti, S., Tasiopoulou, A., Nadarajah, S., Abraham, S., Vala, R., Singh, R., Sharma, A., Sharma, K., Zierhut, M., Raje, D., Cunningham, E., and Kempen, J.

Subjects
medicine.medical_specialty, Tuberculosis, POLYMERASE-CHAIN-REACTION, DIAGNOSIS, DISEASE, LATENT TUBERCULOSIS, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, SERPIGINOUS-LIKE CHOROIDITIS, INTRAOCULAR TUBERCULOSIS, MANAGEMENT, medicine, 030212 general & internal medicine, RETINAL VASCULITIS, Science & Technology, Latent tuberculosis, business.industry, Retinal vasculitis, Collaborative Ocular Tuberculosis Study (COTS)–1 Study Group, Hazard ratio, Panuveitis, Retrospective cohort study, GLOBAL BURDEN, medicine.disease, Surgery, ANTERIOR UVEITIS, Ophthalmology, 030221 ophthalmology & optometry, Intermediate uveitis, business, Life Sciences & Biomedicine, Uveitis
Abstract

Importance Eradication of systemic tuberculosis (TB) has been limited by neglected populations and the HIV pandemic. Whereas ocular TB often presents as uveitis without any prior evidence of systemic TB, the existing uncertainty in the diagnosis of TB uveitis may perpetuate missed opportunities to address systemic TB. Objective To examine the clinical features of TB uveitis and the associations with response to antitubercular therapy (ATT). Design, Setting, and Participants This retrospective multinational cohort study included patients from 25 ophthalmology referral centers diagnosed with TB uveitis and treated with ATT from January 1, 2004, through December 31, 2014, with a minimum follow-up of 1 year. Main Outcomes and Measures Treatment failure, defined as a persistence or recurrence of inflammation within 6 months of completing ATT, inability to taper oral corticosteroids to less than 10 mg/d or topical corticosteroid drops to less than 2 drops daily, and/or recalcitrant inflammation necessitating corticosteroid-sparing immunosuppressive therapy. Results A total of 801 patients (1272 eyes) were studied (mean [SD] age, 40.5 [14.8] years; 413 [51.6%] male and 388 [48.4%] female; 577 [73.6%] Asian). Most patients had no known history (498 of 661 [75.3%]) of systemic TB. Most patients had bilateral involvement (471 of 801 [58.8%]). Common clinical signs reported include vitreous haze (523 of 1153 [45.4%]), retinal vasculitis (374 of 874 [42.8%]), and choroidal involvement (419 of 651 [64.4%]). Treatment failure developed in 102 of the 801 patients (12.7%). On univariate regression analysis, the hazard ratios (HRs) associated with intermediate uveitis (HR, 2.21; 95% CI, 1.07-4.55; P = .03), anterior uveitis (HR, 2.68; 95% CI, 1.32-2.35; P = .006), and panuveitis (HR, 3.28; 95% CI, 1.89-5.67; P

Published
2017
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31. Palladium-Arene Interactions in Catalytic Intermediates: an Experimental and Theoretical Investigation of the Soft Rearrangement between eta1 and eta2 Coordination Modes

Author

Catellani M., Mealli C., Motti E., Paoli P., Perez-Carreno E., and Pregosin P. S.

Subjects
Agostic Interactions, Energy Profiles, DFT calculations, Catalysis, C-H Activation
Abstract

A series of dichloro bridged arylbicycloheptylpalladium complexes have been synthesized and characterized by means of NMR spectroscopy. The compound [(C15H19)PdCl]2 with ortho and para methyl substituents at the arene has been characterized by means of X-ray diffraction techniques. The C-ipso atom of the arene lies almost at the fourth planar coordination site of the metal [Pd-Cipso = 2.22(1)Å (ave.)] and, due to the arene's tilting, the substituted Cortho atom is relatively close to the metal atom [2.54(1)Å (ave)]. The coordinated Cipso Cortho linkage, in a seemingly dihapto coordination, is anti with respect to the CH2 bridge of the bicycloheptyl unit. Variable temperature NMR experiments for the para substituted dimer 9 reveal restricted rotation of the two aryl groups about the corresponding C Cipso bonds (less then 17 kcal mol-1). DFT-B3LYP calculations have been carried out on the known and similar monomer (phenylbicycloheptenyl)Pd(PPh3)I, 4, and its related substituted derivatives. The essential results are: i) the potential energy surface for twisting the phenyl ring away from the symmetric eta1 coordination in 4 is very flat (DeltaE < 1 kcal mol-1) whereas an Atom In Molecules analysis excludes the existence of an actual Pd C-ortho bond in the seemingly eta2–type conformer. ii) complete rotation of the unsubstituted phenyl ring is not facile but feasible. A significant strain affects the transition state structure featuring a Pd-HCaryl agostic-type bond. The calculated destabilization of 10.3 kcal mol-1, with respect to the ground state, can be compared to the experimental barrier of the dimer 9. iii) various methyl substituted derivatives of 4 have been optimized and their structural and energetic trends are discussed. An almost ideal eta1 coordination is shown by the anti conformer of the Cortho substituted complex due steric effects. For all of the other cases, a slipped eta2 coordination may be described. As a general conclusion, the unsaturated metal center receives pi electron density of the arene mainly through its C-ipso atom. The effect may be slightly improved if also the Cortho atom gets closer to the metal but, in no case, the slipped eta2 coordination seems to be crucial for the stability of the system.

Published
2001

35. Index of Suspicion * Case 1: Persistent Fever and Cough Following Episodes of Emesis in a 7-year-old Girl * Case 2: Blurry Vision and Unilateral Dilated Pupil in a 14-year-old Girl * Case 3: Swelling, Pain, and Erythema of the Thumb in a 10-year-old Girl With Habits of Nail Biting and Thumb Sucking

Author

Balighian, E., primary, Tuli, S. Y., additional, Tuli, S. S., additional, Castillo, C., additional, Carreno, E., additional, Carreras, Y., additional, Marino, C., additional, and Mendez, M., additional

Published
2011
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47. The 7 June 2007 mbLg 4.2 Escopete Earthquake: An Event with Significant Ground Motion in a Stable Zone (Central Iberian Peninsula)

Author

Carreno, E., primary, Benito, B., additional, Solares, J. M. M., additional, Cabanas, L., additional, Giner, J., additional, Murphy, P., additional, Lopez, C., additional, Del Fresno, C., additional, Alcalde, J. M., additional, Gaspar-Escribano, J. M., additional, Anton, R., additional, Martinez-Diaz, J., additional, Cesca, S., additional, Izquierdo, A., additional, Cabanero, J. G. S., additional, and Exposito, P., additional

Published
2008
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