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169 results on '"Carreira, Isabel Marques"'

1. List of contributors

Author

Abrantes, Margarida, primary, Alves, Raquel, additional, Anugula, Sharath, additional, Aran, Veronica, additional, Badimon, Lina, additional, Barreto, Jorge N., additional, Bartosz, Grzegorz, additional, Borges, Fernanda, additional, Borrás, Consuelo, additional, Botelho, Maria Filomena, additional, Bousquet, Jean, additional, Brehm, António M.D., additional, Brito, Gerly A.C., additional, Bultje, Daan, additional, Cabral, Ana Cristina, additional, Caetano, André, additional, Canhão, Helena, additional, Carreira, Isabel Marques, additional, Carriazo, Ana Maria, additional, Carvalho, Cristina, additional, Carvalho, Eugenia, additional, Castel-Branco, Margarida, additional, Chen, Yaohua, additional, Coelho-Filho, João M., additional, Constâncio, Vera, additional, Correia e Silva, António, additional, Costa, Deiziane V.S., additional, Costa, Elísio, additional, Costa, Inês, additional, Cunha-Oliveira, Teresa, additional, de Carvalho, Paulo, additional, De Luca, Vicenzo, additional, de Natale, Edoardo R., additional, Dias, Jorge, additional, Dias, Ronaldo P., additional, Duarte, Ana I., additional, Farrel, John, additional, Fernandez-Llimos, Fernando, additional, Ferreira, Lino, additional, Ferrucci, Luigi, additional, Figueiredo, Isabel Vitoria, additional, Ford, Jamie K., additional, Franceschi, Claudio, additional, Freitas, Alex A., additional, Furlan de Brito, Maja, additional, Giacomin, Karla C., additional, Girao, Henrique, additional, Gkikas, Ilias, additional, Gomes, Bárbara, additional, Gomes, Rodrigo M., additional, Gonçalves, Ana Cristina, additional, Goulden, Peter, additional, Grant, Marcus, additional, Grilo, Luís F., additional, Guldemond, Nick, additional, Henriques, Jorge, additional, Heringer, Manoela, additional, Illario, Maddalena, additional, Jerónimo, Carmen, additional, Jones, John G., additional, Jorge, Joana, additional, Kabiri, Yaschar, additional, Karkucinska-Wieckowska, Agnieszka, additional, Kelly, George, additional, Kirkland, James L., additional, Kitaeva, Kristina, additional, Kiyasov, Andrey, additional, Korolchuk, Viktor I., additional, Laranjo, Mafalda, additional, LaRocca, Thomas J., additional, Lavrador, Marta, additional, Lebiedzinska-Arciszewska, Magdalena, additional, Li, Zhiquan, additional, Liu, Yuezhong, additional, Lourenço, Alexandre, additional, Ma, Lina, additional, Malva, João O., additional, Martens, Christopher R., additional, Mas-Bargues, Cristina, additional, Matafome, Paulo, additional, Melo, Joana Barbosa, additional, Mendonça, Maria L. Lima, additional, Metaxakis, Athanasios, additional, Middleton, Lefkos T., additional, Moreira, Paula I., additional, Nascimento, Judite M., additional, Neto, Vivaldo M., additional, Oliveira, Paulo J., additional, Ori, Alessandro, additional, Oriá, Reinaldo B., additional, Ozanne, Susan E., additional, Padeiro, Miguel, additional, Padro, Teresa, additional, Palmeira, Carlos M., additional, Pan, Yiming, additional, Paredes, Simão, additional, Passos, João F., additional, Pereira, Edith, additional, Pereira, Francisco B., additional, Pereira, Susana P., additional, Pinton, Paolo, additional, Pires, Joana F., additional, Pires, Salomé, additional, Polidori, M. Cristina, additional, Politis, Marios, additional, Raimundo, Nuno, additional, Ramalho-Santos, João, additional, Rasmussen, Lene Juel, additional, Regateiro, Fernando J., additional, Reis, Dario D., additional, Ribeiro, Caio, additional, Ribeiro, Ilda Patrícia, additional, Ribeiro-Rodrigues, Teresa M., additional, Rizvanov, Albert, additional, Rocha, Teresa, additional, Röhr, Susanne, additional, Rolo, Anabela P., additional, Román-Domínguez, Aurora, additional, Romero-Ortuno, Roman, additional, Rosa, Manuel Santos, additional, Rutland, Catrin, additional, Sadowska-Bartosz, Izabela, additional, Santana, Paula, additional, Santinha, Deolinda, additional, Santos, Marcos, additional, Sarmento Ribeiro, Ana Bela, additional, Semedo, Deisa S.R.C., additional, Sequeira, João, additional, Sierra, Felipe, additional, Silva, Maria Natalina L., additional, Solana, Rafael, additional, Solovyeva, Valeriya, additional, Spínola, Hélder, additional, Tavares, Renata S., additional, Tavernarakis, Nektarios, additional, Tchkonia, Tamar, additional, Theng, Yin-Leng, additional, Traver-Salcedo, Vicente, additional, Udeh-Momoh, Chi, additional, Verma, Rakhi, additional, Victorelli, Stella, additional, Vilaça, Andreia, additional, Vilahur, Gemma, additional, Viña, José, additional, von Zglinicki, Thomas, additional, Wahl, Devin, additional, Werle, Berenice Maria, additional, Wieckowski, Mariusz R., additional, Wilson, Heather, additional, Wissler Gerdes, Erin O., additional, Wozniak, Lucyna A., additional, Zavan, Barbara, additional, Zhu, Yi, additional, and Zischka, Hans, additional

Published
2023
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2. Aging-related neoplasia

Author

Sarmento Ribeiro, Ana Bela, primary, Botelho, Maria Filomena, additional, Gonçalves, Ana Cristina, additional, Melo, Joana Barbosa, additional, Laranjo, Mafalda, additional, Alves, Raquel, additional, Jorge, Joana, additional, Ribeiro, Ilda Patrícia, additional, Pires, Salomé, additional, Abrantes, Margarida, additional, Constâncio, Vera, additional, Jerónimo, Carmen, additional, Carreira, Isabel Marques, additional, Rosa, Manuel Santos, additional, and Solana, Rafael, additional

Published
2023
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3. Molecular Karyotyping

Author

Ribeiro, Ilda Patrícia, primary, Pires, Luís Miguel, additional, Ferreira, Susana Isabel, additional, Val, Mariana, additional, Melo, Joana Barbosa, additional, and Carreira, Isabel Marques, additional

Published
2022
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7. The Diagnostic and Prognostic Potentials of Non-Coding RNA in Cholangiocarcinoma.

Author

Andrade, Rita, Ribeiro, Ilda Patrícia, Carreira, Isabel Marques, and Tralhão, José Guilherme

Subjects
CIRCULAR RNA, NON-coding RNA, LINCRNA, CHOLANGIOCARCINOMA, GENE expression, BILIARY tract
Abstract

Cholangiocarcinoma (CCA) is a rare biliary tract tumor with high malignancy. CCA is the second most common primary hepatobiliary cancer after hepatocarcinoma. Despite its rarity, the incidence of CCA is steadily increasing globally. Most patients with CCA are asymptomatic in the early stages, resulting in a late-stage diagnosis and poor prognosis. Finding reliable biomarkers is essential to improve CCA's early diagnosis and survival rate. Non-coding RNAs (ncRNAs) are non-protein coding RNAs produced by genomic transcription. This includes microRNAs, long non-coding RNAs, and circular RNAs. ncRNAs have multiple functions in regulating gene expression and are crucial for maintaining normal cell function and developing diseases. Many studies have shown that aberrantly expressed ncRNAs can regulate the occurrence and development of CCA. ncRNAs can be easily extracted and detected through tumor tissue and liquid biopsies, representing a potential tool for diagnosing and prognosis CCA. This review will provide a detailed update on the diagnostic and prognostic potentials of lncRNAs and cirRNAs as biomarkers in CCA. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Identification of Novel Molecular and Clinical Biomarkers of Survival in Glioblastoma Multiforme Patients: A Study Based on The Cancer Genome Atlas Data.

Author

Esteves, Luísa, Caramelo, Francisco, Roda, Domingos, Carreira, Isabel Marques, Melo, Joana Barbosa, and Ribeiro, Ilda Patrícia

Subjects
METHYLATION, GLIOMAS, MICROBIAL virulence, CANCER patient medical care, SYMPTOMS, CELLULAR signal transduction, DESCRIPTIVE statistics, DECISION making in clinical medicine, GENE expression, KAPLAN-Meier estimator, CANCER chemotherapy, MESSENGER RNA, GENETIC mutation, TUMORS, SURVIVAL analysis (Biometry), CONFIDENCE intervals, MOLECULAR biology, BIOMARKERS, PROPORTIONAL hazards models, REGRESSION analysis, GENOMES
Abstract

Glioblastoma multiforme (GBM) is the most prevalent type of brain tumour; although advancements in treatment have been made, the median survival time for GBM patients has persisted at 15 months. This study is aimed at investigating the genetic alterations and clinical features of GBM patients to find predictors of survival. GBM patients' methylation and gene expression data along with clinical information from TCGA were retrieved. The most overrepresented pathways were identified independently for each omics dataset. From the genes found in at least 30% of these pathways, one gene that was identified in both sets was further examined using the Kaplan-Meier method for survival analysis. Additionally, three groups of patients who started radio and chemotherapy at different times were identified, and the influence of these variations in treatment modality on patient survival was evaluated. Four pathways that seemed to negatively impact survival and two with the opposite effect were identified. The methylation status of PRKCB was highlighted as a potential novel biomarker for patient survival. The study also found that treatment with chemotherapy prior to radiotherapy can have a significant impact on patient survival, which could lead to improvements in clinical management and therapeutic approaches for GBM patients. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Cx43 can form functional channels at the nuclear envelope and modulate gene expression in cardiac cells

Author

Martins-Marques, Tania, primary, Witschas, Katja, additional, Ribeiro, Ilda, additional, Zuzarte, Mónica, additional, Catarino, Steve, additional, Ribeiro-Rodrigues, Teresa, additional, Caramelo, Francisco, additional, Aasen, Trond, additional, Carreira, Isabel Marques, additional, Goncalves, Lino, additional, Leybaert, Luc, additional, and Girao, Henrique, additional

Published
2023
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12. AZD-7648, a DNA-PK Inhibitor, Induces DNA Damage, Apoptosis, and Cell Cycle Arrest in Chronic and Acute Myeloid Leukemia Cells

Author

Lapa, Beatriz Santos, primary, Costa, Maria Inês, additional, Figueiredo, Diana, additional, Jorge, Joana, additional, Alves, Raquel, additional, Monteiro, Ana Raquel, additional, Serambeque, Beatriz, additional, Laranjo, Mafalda, additional, Botelho, Maria Filomena, additional, Carreira, Isabel Marques, additional, Sarmento-Ribeiro, Ana Bela, additional, and Gonçalves, Ana Cristina, additional

Published
2023
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14. Oculo-auriculo-vertebral spectrum: Clinical and molecular analysis of 51 patients

Author

Beleza-Meireles, Ana, Hart, Rachel, Clayton-Smith, Jill, Oliveira, Renata, Reis, Cláudia Falcão, Venâncio, Margarida, Ramos, Fabiana, Sá, Joaquim, Ramos, Lina, Cunha, Elizabete, Pires, Luís Miguel, Carreira, Isabel Marques, Scholey, Rachel, Wright, Ronnie, Urquhart, Jill E., Briggs, Tracy A., Kerr, Bronwyn, Kingston, Helen, Metcalfe, Kay, Donnai, Dian, Newman, William G., Saraiva, Jorge Manuel, and Tassabehji, May

Published
2015
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18. Chapter 21 - Aging-related neoplasia

Author

Sarmento Ribeiro, Ana Bela, Botelho, Maria Filomena, Gonçalves, Ana Cristina, Melo, Joana Barbosa, Laranjo, Mafalda, Alves, Raquel, Jorge, Joana, Ribeiro, Ilda Patrícia, Pires, Salomé, Abrantes, Margarida, Constâncio, Vera, Jerónimo, Carmen, Carreira, Isabel Marques, Rosa, Manuel Santos, and Solana, Rafael

Published
2023
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25. Basal cell carcinomas of the scalp after radiotherapy for tinea capitis: Clinicopathological study in a case series of 96 patients with analysis of 427 tumours.

Author

Cardoso, José Carlos, Alves, Francisca, Calado, Rebeca, Batista, Mariana, Carreira, Isabel Marques, and Tellechea, Oscar

Subjects
BASAL cell carcinoma, SCALP, INDUCTIVE effect, TUMORS, CLINICAL pathology, SKIN cancer, THYROID diseases
Abstract

Background/Objectives: Low‐dose X‐ray radiotherapy to treat tinea capitis during childhood is a well‐known risk factor for scalp basal cell carcinomas (BCCs). Post‐radiotherapy BCCs are often multiple, and it has been suggested that they display more aggressive features. Our main objective was to study the clinicopathological aspects of post‐radiotherapy BCCs to evaluate their biological behaviour and identify features that may differ from other BCCs. Methods: We performed an observational, retrospective study assessing multiple clinical and pathological characteristics of patients with post‐radiotherapy BCCs. Results: We studied 96 patients with 427 post‐radiotherapy scalp BCCs. Post‐radiotherapy BCCs were often multiple (median of 4 lesions/patient, ranging from 1 to 54). Significant comorbidities included a high incidence of thyroid disease and meningiomas. Recurrences were observed in 23% of patients, but there may be confounding factors, such as referral bias, heterogenous treatment modalities and occurrence of new tumours due to field effect. We found a high incidence of infundibulocystic BCCs (in 14.6% of patients and corresponding to 5.4% of the total number of tumours), trichoblastomas (5.2%) and neurofibromas of the scalp (10%). Conclusions: This study is consistent with the occurrence of multiple lesions (sometimes numerous) and a relatively high tendency for recurrence in post‐radiotherapy BCCs, as suggested by previous studies. We also found a high incidence of the infundibulocystic variant and a higher risk of follicular tumours and neurofibromas, which suggests that radiotherapy may influence the type of differentiation of BCCs and contribute to induce neoplasms of different cell lines. [ABSTRACT FROM AUTHOR]

Published
2023
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29. Development of a genomic predictive model for cholangiocarcinoma using copy number alteration data

Author

Tavares, Inês, primary, Martins, Ricardo, additional, Ribeiro, Ilda Patrícia, additional, Esteves, Luísa, additional, Caramelo, Francisco, additional, Abrantes, Ana Margarida, additional, Neves, Rita, additional, Caetano-Oliveira, Rui, additional, Botelho, Maria Filomena, additional, Barbosa de Melo, Joana, additional, Diogo, Dulce, additional, Tralhão, José Guilherme, additional, and Carreira, Isabel Marques, additional

Published
2021
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31. Development of a genomic predictive model for cholangiocarcinoma using copy number alteration data.

Author

Tavares, Inês, Martins, Ricardo, Ribeiro, Ilda Patrícia, Esteves, Luísa, Caramelo, Francisco, Abrantes, Ana Margarida, Neves, Rita, Caetano-Oliveira, Rui, Botelho, Maria Filomena, de Melo, Joana Barbosa, Diogo, Dulce, Tralhão, José Guilherme, and Carreira, Isabel Marques

Subjects
INTRAHEPATIC bile ducts, CHOLANGIOCARCINOMA, FORKHEAD transcription factors, PREDICTION models, NECK
Published
2022
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32. Tremor is a major feature of 9p13 deletion syndrome

Author

Ferreira, Susana Isabel, primary, Cinnirella, Giacomo, additional, Ramos, Lina, additional, Suppa, Antonio, additional, Pires, Luís Miguel, additional, Nardone, Anna Maria, additional, Camerota, Letizia, additional, Lanciotti, Silvia, additional, Galasso, Cinzia, additional, De Maio, Fernando, additional, Melo, Joana Barbosa, additional, Carreira, Isabel Marques, additional, and Brancati, Francesco, additional

Published
2020
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33. Intratumoral Heterogeneity in Uveal Melanoma

Author

Fonseca, Cristina, primary, Pinto-Proença, Rita, additional, Bergeron, Sabrina, additional, Pires, Luís Miguel, additional, Fernandes, Júlia, additional, Carreira, Isabel Marques, additional, Burnier, Miguel N., additional, and Proença, Rui, additional

Published
2020
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35. Abordagens citogenéticas e genómicas: perspetiva no diagnóstico em oncologia e nas patologias do neurodesenvolvimento

Author

Ribeiro,Ilda Patrícia, Carreira,Isabel Marques, and Melo,Joana Barbosa de

Subjects
epigenética, variação do número de cópias, citogenética, cancro, genómica, patologias do neurodesenvolvimento, biomarcadores de diagnóstico e prognóstico
Abstract

Resumo As técnicas de citogenética e genómica permitem uma caracterização abrangente ou mais direcionada do genoma nuclear humano. A seleção do tipo de técnica a utilizar depende do objetivo do estudo, sendo sempre importante a correlação genótipo-fenótipo para uma correta interpretação dos resultados. Neste artigo apresentamos e discutimos algumas das principais tecnologias no campo da citogenética e genómica aplicadas no âmbito do diagnóstico e da investigação, evidenciando as suas vantagens em áreas tão diferentes como a oncologia e as patologias do neurodesenvolvimento. De facto, o cancro está associado à aquisição de várias alterações genéticas e epigenéticas nas células que devem ser caracterizadas e, do mesmo modo, as perturbações do neurodesenvolvimento que resultam de alterações neurobiológicas têm frequentemente origem em alterações genéticas. Assim, tanto em cancro como em patologias do neurodesenvolvimento, o recurso às várias técnicas de citogenética convencional, molecular e genómica é essencial, não só no âmbito da investigação mas também no diagnóstico e prognóstico, com o intuito de identificar e caracterizar alterações genéticas e padrões epigenéticos associados ao desenvolvimento e progressão da doença.

Published
2018

38. Genomic characterisation of multiple myeloma: study of a Portuguese cohort

Author

Couto Oliveira, Alexandra, Ribeiro, Ilda Patrícia, Pires, Luís Miguel, Goncalves, Ana Cristina, Paiva, Artur, Geraldes, Catarina, Roque, Adriana, Sarmento-Ribeiro, Ana Bela, Barbosa de Melo, Joana, and Carreira, Isabel Marques

Abstract

Multiple myeloma (MM) genomic complexity reflects in the variable patients’ clinical presentation. Genome-wide studies seem to be a reasonable alternative to identify critical genomic lesions. In the current study, we have performed the genomic characterisation of a Portuguese cohort of patients with MM by array comparative genomic hybridisation. Overall, the most frequently detected alterations were 13q deletions, gains of 1q, 19p, 15q, 5p and 7p and trisomy 9. Even though some identified genomic alterations were previously associated with a prognostic value, other abnormalities remain with unknown, but putative significance for patients’ clinical practice. These genomic alterations should be further assessed as possible biomarkers.

Published
2022
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40. Upper aerodigestive tract carcinoma: Development of a (epi)genomic predictive model for recurrence and metastasis.

Author

Ribeiro, Ilda Patrícia, Caramelo, Francisco, Ribeiro, Margarida, Machado, Ana, Miguéis, Jorge, Marques, Francisco, Carreira, Isabel Marques, and Melo, Joana Barbosa

Subjects
COMPARATIVE genomic hybridization, PREDICTION models, CARCINOMA, METASTASIS, DRUG design
Abstract

Despite the increased molecular knowledge and the diagnostic and therapeutic improvements, the survival of patients with upper aerodigestive tract carcinoma remains poor. The identification of early diagnostic and prognostic biomarkers and the development of molecular models to distinguish patients that will recur and/or develop metastasis after treatment as well as to benefit with target therapies can be important to decrease mortality, improve survival rates and improve the quality of life of these patients. The current study analyzed 21 upper aerodigestive tract carcinomas through array comparative genomic hybridization and methylation-specific multiplex ligation-dependent probe amplification techniques. A number of chromosomal regions and genes were observed with copy number alterations and methylation. A predictive (epi)genomic model that comprises the 3p chromosomal region and WT1, VHL and THBS1 genes was built, highlighting a molecular signature with possible clinical use. The current study may aid in the development of a more individualized patient management and targeted drug design. The power of this genomic and epigenetic model to predict the recurrence and metastasis development should be evaluated and validated in future larger cohort study. [ABSTRACT FROM AUTHOR]

Published
2020
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41. Generation and characterization of a human iPS cell line from a patient-related control to study disease mechanisms associated with DAND5 p.R152H alteration

Author

Pars, Selin, primary, Cristo, Fernando, additional, Inácio, José M., additional, Rosas, Graça, additional, Carreira, Isabel Marques, additional, Melo, Joana Barbosa, additional, Mendes, Patrícia, additional, Martins, Duarte Saraiva, additional, de Almeida, Luís Pereira, additional, Maio, José, additional, Anjos, Rui, additional, and Belo, José A., additional

Published
2018
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43. Generation of human iPSC line from a patient with laterality defects and associated congenital heart anomalies carrying a DAND5 missense alteration

Author

Cristo, Fernando, primary, Inácio, José M., additional, Rosas, Graça, additional, Carreira, Isabel Marques, additional, Melo, Joana Barbosa, additional, de Almeida, Luís Pereira, additional, Mendes, Patrícia, additional, Martins, Duarte Saraiva, additional, Maio, José, additional, Anjos, Rui, additional, and Belo, José A., additional

Published
2017
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47. Copy number variants prioritization after array-CGH analysis – a cohort of 1000 patients

Author

Carreira, Isabel Marques, primary, Ferreira, Susana Isabel, additional, Matoso, Eunice, additional, Pires, Luís Miguel, additional, Ferrão, José, additional, Jardim, Ana, additional, Mascarenhas, Alexandra, additional, Pinto, Marta, additional, Lavoura, Nuno, additional, Pais, Cláudia, additional, Paiva, Patrícia, additional, Simões, Lúcia, additional, Caramelo, Francisco, additional, Ramos, Lina, additional, Venâncio, Margarida, additional, Ramos, Fabiana, additional, Beleza, Ana, additional, Sá, Joaquim, additional, Saraiva, Jorge, additional, and de Melo, Joana Barbosa, additional

Published
2015
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48. Cytogenetic alterations induced by radiation in amniocytes

Author

Pires, Ana Salomé, Pinto, Marta, Silveira, Paula, Brito, Ana Filipa, Fonseca, Sérgio, Castro, Ismael, Diaz, Sílvia, Cunha, Ana Luísa, Ferreira, Marisa, Zambetti, Marta, Lopes, Maria do Carmo, Carreira, Isabel Marques, and Botelho, Maria Filomena

Subjects
cellular activity, chemical reactions, ionizing radiation, amniocytes
Abstract

When cells are submitted to ionizing radiation, they respond with physico-chemical phenomena like ionization/excitation of atoms and energy distribution over the cells, chemical reactions with formation of freeradicals and rupture of chemical bonds and biological alterations leading to specific changes of cellular functions with decrease of cellular activity. Therefore, both tissues and organs are affected through direct and indirect effects. Among these effects, the interaction of radiation with chromosomes is a critical step since they contain the cell’s genetic information. (...)

Published
2007

49. Genetic gains and losses in oral squamous cell carcinoma: impact on clinical management

Author

Ribeiro, Ilda Patrícia, primary, Marques, Francisco, additional, Caramelo, Francisco, additional, Pereira, João, additional, Patrício, Miguel, additional, Prazeres, Hugo, additional, Ferrão, José, additional, Julião, Maria José, additional, Castelo-Branco, Miguel, additional, de Melo, Joana Barbosa, additional, Baptista, Isabel Poiares, additional, and Carreira, Isabel Marques, additional

Published
2013
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