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2. Intranasal Multiepitope PD‐L1‐siRNA‐Based Nanovaccine: The Next‐Gen COVID‐19 Immunotherapy.

Author

Acúrcio, Rita C., Kleiner, Ron, Vaskovich‐Koubi, Daniella, Carreira, Bárbara, Liubomirski, Yulia, Palma, Carolina, Yeheskel, Adva, Yeini, Eilam, Viana, Ana S., Ferreira, Vera, Araújo, Carlos, Mor, Michael, Freund, Natalia T., Bacharach, Eran, Gonçalves, João, Toister‐Achituv, Mira, Fabregue, Manon, Matthieu, Solene, Guerry, Capucine, and Zarubica, Ana

Subjects
SARS-CoV-2, IMMUNE checkpoint proteins, INTRANASAL administration, VACCINE approval, DENDRITIC cells
Abstract

The first approved vaccines for human use against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) are nanotechnology‐based. Although they are modular, rapidly produced, and can reduce disease severity, the currently available vaccines are restricted in preventing infection, stressing the global demand for novel preventive vaccine technologies. Bearing this in mind, we set out to develop a flexible nanovaccine platform for nasal administration to induce mucosal immunity, which is fundamental for optimal protection against respiratory virus infection. The next‐generation multiepitope nanovaccines co‐deliver immunogenic peptides, selected by an immunoinformatic workflow, along with adjuvants and regulators of the PD‐L1 expression. As a case study, we focused on SARS‐CoV‐2 peptides as relevant antigens to validate the approach. This platform can evoke both local and systemic cellular‐ and humoral‐specific responses against SARS‐CoV‐2. This led to the secretion of immunoglobulin A (IgA), capable of neutralizing SARS‐CoV‐2, including variants of concern, following a heterologous immunization strategy. Considering the limitations of the required cold chain distribution for current nanotechnology‐based vaccines, it is shown that the lyophilized nanovaccine is stable for long‐term at room temperature and retains its in vivo efficacy upon reconstitution. This makes it particularly relevant for developing countries and offers a modular system adaptable to future viral threats. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Multifunctional Nanovaccine Sensitizes Breast Cancer to Immune Checkpoint Therapy

Author

Peres, Carina, primary, Matos, Ana I., additional, Carreira, Bárbara, additional, Moura, Liane I. F., additional, Kleiner, Ron, additional, Vaskovich‐Koubi, Daniella, additional, Reshef, Keren, additional, Dulberg, Shai, additional, Verdial, Mafalda, additional, Conniot, João, additional, Afonso, Marta B., additional, Acúrcio, Rita C., additional, Basto, Afonso P., additional, Mensurado, Sofia, additional, Silva‐Santos, Bruno, additional, Santos, Susana Constantino Rosa, additional, Viana, Ana S., additional, Silva, Liana C., additional, Rodrigues, Cecília M. P., additional, Préat, Véronique, additional, Graça, Luís, additional, Madi, Asaf, additional, Satchi‐Fainaro, Ronit, additional, and Florindo, Helena F., additional

Published
2024
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6. Functional Moieties for Intracellular Traffic of Nanomaterials

Author

Silva, Ana L., primary, Moura, Liane I.F., additional, Carreira, Bárbara, additional, Conniot, João, additional, Matos, Ana I., additional, Peres, Carina, additional, Sainz, Vanessa, additional, Silva, Liana C., additional, Gaspar, Rogério S., additional, and Florindo, Helena F., additional

Published
2018
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7. List of Contributors

Author

Amiji, Mansoor M., primary, Araújo, Marco, additional, Asai, Tomohiro, additional, Avvakumova, Svetlana, additional, Barrias, Cristina C., additional, Budak, Hikmet, additional, Burnett, John C., additional, Cambria, Maria T., additional, Cao, Wen, additional, Carreira, Bárbara, additional, Chithrani, Devika B., additional, Colombo, Miriam, additional, Condorelli, Guglielmo G., additional, Conniot, João, additional, Csaba, Noemi S., additional, Ehmann, Falk, additional, Feijão, Tália, additional, Fernandes, Cláudia S.M., additional, Ferreira, Fabrícia Saba, additional, Florindo, Helena F., additional, Freitas, Sidónio C., additional, Galbiati, Elisabetta, additional, Gaspar, Rogério S., additional, Gonzalez-Pajuelo, Maria, additional, Huang, Leaf, additional, Huang, Peng, additional, Huang, Yan, additional, Hudalla, Gregory A., additional, Hussain, Babar, additional, Iranzo, Olga, additional, Janas, Christine, additional, Kharlamov, Alexander N., additional, Kumar, Priyadarshi, additional, Kurt, Hasan, additional, Leiro, Victoria, additional, Lin, Jing, additional, Lin, Shichao, additional, Li, Shasha, additional, Li, Zibiao, additional, Lozano, M. Victoria, additional, Martins, Maria Cristina L., additional, Matos, Ana I., additional, Mazzucchelli, Serena, additional, Moura, Liane I.F., additional, Muhammad, Faheem, additional, Oku, Naoto, additional, Parreira, Paula, additional, Pêgo, Ana Paula, additional, Peres, Carina, additional, Pita, Ruben, additional, Prosperi, Davide, additional, Rahikkala, Antti, additional, Roque, Ana C.A., additional, Rosenholm, Jessica M., additional, Rotem, Rany, additional, Sainz, Vanessa, additional, Santander-Ortega, Manuel J., additional, Santos, Hélder A., additional, Seroski, Dillon T., additional, Silva, Ana L., additional, Silva, Liana C., additional, Singh, Amit, additional, Sosnik, Alejandro, additional, Teixeira, Daniela, additional, Teixeira, Gonçalo D.G., additional, Thürmer, René, additional, Thwala, Lungile N., additional, Torres, Ana L., additional, Tudisco, Cristina, additional, Vieira, Fernanda Pires, additional, Wacker, Matthias G., additional, Wada, Akira, additional, Wei, Hui, additional, Wong, Swee Liang, additional, Wu, Jiangjiexing, additional, Yao, Jia, additional, and Yüce, Meral, additional

Published
2018
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