1. Liquid biopsies in lung cancer: The new ambrosia of researchers
- Author
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Rolfo, C, Castiglia, M, Hong, D, Alessandro, R, Mertens, I, Baggerman, G, Zwaenepoel, K, Gil-Bazo, I, Passiglia, F, Carreca, AP, Taverna, S, Vento, R, Peeters, M, Russo, A, Pauwels, P, Rolfo, C, Castiglia, M, Hong, D, Alessandro, R, Mertens, I, Baggerman, G, Zwaenepoel, K, Gil-Bazo, I, Passiglia, F, Carreca, AP, Taverna, S, Vento, R, Peeter, Russo, A, and Pauwels, P
- Subjects
Oncology ,Cancer Research ,medicine.medical_specialty ,Lung Neoplasms ,Pleural effusion ,Settore MED/06 - Oncologia Medica ,Biopsy ,exosomes ,circulating tumor cells ,Circulating tumor cell ,Settore BIO/13 - Biologia Applicata ,Internal medicine ,Settore BIO/10 - Biochimica ,Genetics ,medicine ,Biomarkers, Tumor ,exosome ,Animals ,Humans ,cancer ,Biomarker discovery ,Liquid biopsy ,Lung cancer ,Biology ,liquid biopsy ,business.industry ,Physics ,Cancer ,DNA, Neoplasm ,medicine.disease ,Neoplastic Cells, Circulating ,Chemistry ,Immunology ,Biomarker (medicine) ,Human medicine ,Personalized medicine ,business - Abstract
In the last decades the approach to cancer patient management has been deeply revolutionized. We are moving from a "one-fits-all" strategy to the "personalized medicine" based on the molecular characterization of the tumor. In this new era it is becoming more and more clear that the monitoring of the disease is fundamental for the success of the treatment, thus there is the need of new biomarker discovery. More precisely in the last years the scientific community has started to use the term "liquid biopsy". A liquid biopsy is a liquid biomarker that can be easily isolated from many body fluids (blood, saliva, urine, ascites, pleural effusion, etc.) and, as well as a tissue biopsy, a representative of the tissue from which it is spread. In this review we will focus our attention on circulating tumor cells, circulating tumor DNA, exosomes and secretomes with the aim to underlie their usefulness and potential application in a clinical setting for lung cancer patient management. (C) 2014 Elsevier B.V. All rights reserved.
- Published
- 2014