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2. Evans syndrome: Disease awareness and clinical management in a nation‐wide ITP‐NET survey.

Author

Fattizzo, Bruno, Carrai, Valentina, Crugnola, Monica, Baldacci, Erminia, Bellini, Marta, Bosi, Costanza, Buzzatti, Elisa, Caramazza, Domenica, Carli, Giuseppe, Carpenedo, Monica, Clissa, Cristina, Danesin, Cristina, De Paolis, Maria Rosaria, Giannotta, Juri Alessandro, Innao, Vanessa, Marchetti, Monia, Markovic, Uros, Morotti, Alessandro, Napolitano, Mariasanta, and Patriarca, Andrea

Subjects
*AUTOIMMUNE hemolytic anemia, *AUTOIMMUNE diseases, *PRIMARY immunodeficiency diseases, *LYMPHOPROLIFERATIVE disorders, *DISEASE complications, *PHYSICIANS, *SYNDROMES
Abstract

Evans syndrome (ES) is rare and mostly treated on a “case‐by‐case” basis and no guidelines are available. With the aim of assessing disease awareness and current management of adult ES, a structured survey was administered to 64 clinicians from 50 Italian participating centers. Clinicians had to be involved in the management of autoimmune cytopenias and were enrolled into the ITP‐NET initiative. The survey included domains on epidemiology, diagnosis, and therapy of ES and was designed to capture current practice and suggested work‐up and management. Thirty clinicians who had followed a median of 5 patients (1–45)/15 years responded. The combination of AIHA plus ITP was more common than the ITP/AIHA with neutropenia (p < .001) and 25% of patients had an associated condition, including lymphoproliferative syndromes, autoimmune diseases, or primary immunodeficiencies. The agreement of clinicians for each diagnostic test is depicted (i.e., 100% for blood count and DAT; only 40% for anti‐platelets and anti‐neutrophils; 77% for bone marrow evaluation). Most clinicians reported that ES requires a specific approach compared to isolated autoimmune cytopenias, due to either a more complex pathogenesis and a higher risk of relapse and thrombotic and infectious complications. The heterogeneity of treatment choices among different physicians suggests the need for broader harmonization. [ABSTRACT FROM AUTHOR]

Published
2024
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3. PB2611: EVANS SYNDROME: DISEASE AWARENESS AND CLINICAL MANAGEMENT IN A NATION-WIDE ITALIAN SURVEY

Author

Fattizzo, Bruno, primary, Carrai, Valentina, additional, Crugnola, Monica, additional, Baldacci, Erminia, additional, Bellini, Marta, additional, Bosi, Costanza, additional, Buzzatti, Elisa, additional, Caramazza, Domenica, additional, Carli, Giuseppe, additional, Carpenedo, Monica, additional, Clissa, Cristina, additional, Danesin, Cristina, additional, De Paolis, Maria Rosaria, additional, Giannotta, Juri Alessandro, additional, Innao, Vanessa, additional, Marchetti, Monia, additional, Markovic, Uros, additional, Morotti, Alessandro, additional, Napolitano, Mariasanta, additional, Patriarca, Andrea, additional, Pettine, Loredana, additional, Poloni, Antonella, additional, Rivolti, Elena, additional, Rossi, Elena, additional, Santeremo, Teresa Maria, additional, Santoro, Cristina, additional, Zannier, Maria Elena, additional, Zaja, Francesco, additional, Cantoni, Silvia, additional, Palandri, Francesca, additional, and Stefano, Valerio De, additional

Published
2023
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6. Link between Bone Marrow and Cardiac Iron Overload in Thalassemia Major

Author

Meloni, Antonella, primary, Pistoia, Laura, additional, Restaino, Gennaro, additional, Missere, Massimiliano, additional, Positano, Vincenzo, additional, Rosso, Rosamaria, additional, Carrai, Valentina, additional, Maddaloni, Domenico, additional, Rigoli, Luciana, additional, Benni, Monica, additional, Argento, Crocetta, additional, Visceglie, Domenico, additional, Maggio, Aurelio, additional, and Cademartiri, Filippo, additional

Published
2022
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7. Alternate use of thrombopoietin receptor agonists in adult primary immune thrombocytopenia patients: A retrospective collaborative survey from Italian hematology centers

Author

Cantoni, Silvia, Carpenedo, Monica, Mazzucconi, Maria Gabriella, De Stefano, Valerio, Carrai, Valentina, Ruggeri, Marco, Specchia, Giorgina, Vianelli, Nicola, Pane, Fabrizio, Consoli, Ugo, Artoni, Andrea, Zaja, Francesco, Dʼadda, Mariella, Visentin, Andrea, Ferrara, Felicetto, Barcellini, Wilma, Caramazza, Domenica, Baldacci, Erminia, Rossi, Elena, Ricco, Alessandra, Ciminello, Angela, Rodeghiero, Francesco, Nichelatti, Michele, and Cairoli, Roberto

Published
2018
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9. Rapid infusions of human normal immunoglobulin 50 g/l are safe and well tolerated in immunodeficiencies and immune thrombocytopenia

Author

Spadaro, Giuseppe, Vultaggio, Alessandra, Alberto Bosi, A, Reichert, Dietmar, Janssen, Jan, Lamacchia, Donatella, Nappi, Liliana, Pecoraro, Antonio, Milito, Cinzia, Ferraro, Andrea, Matucci, Andrea, Bacchiarri, Francesca, Carrai, Valentina, Hibbeler, Azra, Speckman, Elisabet, Guarnieri, Chiara, Bongiovanni, Serena, and Quinti, Isabella

Published
2017
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10. A prognostic model to predict survival in 867 World Health Organization–defined essential thrombocythemia at diagnosis: a study by the International Working Group on Myelofibrosis Research and Treatment

Author

Passamonti, Francesco, Thiele, Jürgen, Girodon, Francois, Rumi, Elisa, Carobbio, Alessandra, Gisslinger, Heinz, Kvasnicka, Hans Michael, Ruggeri, Marco, Randi, Maria Luigia, Gangat, Naseema, Vannucchi, Alessandro Maria, Gianatti, Andrea, Gisslinger, Bettina, Müllauer, Leonhard, Rodeghiero, Francesco, d'Amore, Emanuele S.G., Bertozzi, Irene, Hanson, Curtis A., Boveri, Emanuela, Marino, Filippo, Maffioli, Margherita, Caramazza, Domenica, Antonioli, Elisabetta, Carrai, Valentina, Buxhofer-Ausch, Veronika, Pascutto, Cristiana, Cazzola, Mario, Barbui, Tiziano, and Tefferi, Ayalew

Published
2012
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12. Italian patients with hemoglobinopathies exhibit a 5‐fold increase in age‐standardized lethality due to SARS‐CoV‐2 infection

Author

Longo, Filomena, primary, Gianesin, Barbara, additional, Voi, Vincenzo, additional, Motta, Irene, additional, Pinto, Valeria Maria, additional, Piolatto, Andrea, additional, Spasiano, Anna, additional, Ruffo, Giovan Battista, additional, Gamberini, Maria Rita, additional, Barella, Susanna, additional, Mariani, Raffaella, additional, Fidone, Carmelo, additional, Rosso, Rosamaria, additional, Casale, Maddalena, additional, Roberti, Domenico, additional, Dal Zotto, Chiara, additional, Vitucci, Angelantonio, additional, Bonetti, Federico, additional, Pitrolo, Lorella, additional, Quaresima, Micol, additional, Ribersani, Michela, additional, Quota, Alessandra, additional, Arcioni, Francesco, additional, Campisi, Saveria, additional, Massa, Antonella, additional, De Michele, Elisa, additional, Lisi, Roberto, additional, Miano, Maurizio, additional, Bagnato, Sabrina, additional, Gentile, Massimo, additional, Carrai, Valentina, additional, Putti, Maria Caterina, additional, Serra, Marilena, additional, Gaglioti, Carmen, additional, Migone De Amicis, Margerita, additional, Graziadei, Giovanna, additional, De Giovanni, Anna, additional, Ricchi, Paolo, additional, Balocco, Manuela, additional, Quintino, Sabrina, additional, Borsellino, Zelia, additional, Fortini, Monica, additional, Denotti, Anna Rita, additional, Tartaglione, Immacolata, additional, Beccaria, Andrea, additional, Marziali, Marco, additional, Maggio, Aurelio, additional, Perrotta, Silverio, additional, Piperno, Alberto, additional, Filosa, Aldo, additional, Cappellini, Maria Domenica, additional, De Franceschi, Lucia, additional, Piga, Antonio, additional, and Forni, Gian Luca, additional

Published
2021
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13. Frequency, Pattern, and Associations of Renal Iron Accumulation in Sickle Beta-Thalassemia

Author

Pepe, Alessia, primary, Barbuto, Luigi, additional, Pistoia, Laura, additional, Positano, Vincenzo, additional, Massei, Francesco, additional, Tedesco, Letizia, additional, Carrai, Valentina, additional, Vitucci, Angelantonio, additional, Maggio, Aurelio, additional, Peritore, Giuseppe, additional, Fina, Priscilla, additional, and Meloni, Antonella, additional

Published
2021
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14. Thrombopoietin receptor agonists for preparing adult patients with immune thrombocytopenia to splenectomy: results of a retrospective, observational GIMEMA study

Author

Zaja, Francesco, Barcellini, Wilma, Cantoni, Silvia, Carpenedo, Monica, Caparrotti, Giuseppe, Carrai, Valentina, Di Renzo, Nicola, Santoro, Cristina, Di Nicola, Massimo, Veneri, Dino, Simonetti, Federico, Liberati, Anna M., Ferla, Valeria, Paoloni, Francesca, Crea, Enrico, Volpetti, Stefano, Tuniz, Enrica, and Fanin, Renato

Published
2016
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15. Nationwide Survey on the Use of Thrombopoietin Receptor Agonists (TPO-RA) for the Management of Immune Thrombocytopenia in Current Clinical Practice in Italy.

Author

Napolitano, Mariasanta, Vianelli, Nicola, Ghiotto, Lisanna, Cantoni, Silvia, Carli, Giuseppe, Carpenedo, Monica, Carrai, Valentina, Consoli, Ugo, Giuffrida, Gaetano, Lucchini, Elisa, Rossi, Elena, Santoro, Cristina, and Rodeghiero, Francesco

Subjects
THROMBOPOIETIN receptor agonists, IDIOPATHIC thrombocytopenic purpura, OLDER patients, BLOOD platelet disorders, ROMIPLOSTIM, ELTROMBOPAG
Abstract

Background: Two thrombopoietin receptor agonists (TPO-RA), romiplostim and eltrombopag, are currently widely adopted as second-line ITP therapy even in the absence of robust evidence on their comparative advantages over rituximab or splenectomy or their preferential use in some specific clinical contexts. Methods: An online survey was distributed between May 2021 and June 2021 to collect standardized information on TPO-RA use in Italy. Results: Eighty-eight hematologists from 79 centers completed the survey. Eighty-four percent would use TPO-RA earlier than formally indicated, without a preference for young or elderly in 82% of respondents. No clear preference for either romiplostim or eltrombopag was indicated. Seventy-two percent would use TPO-RA in young patients aiming at a complete response followed by tapering, a strategy considered by only 16% in the elderly. Switching between the two agents was considered appropriate in case of insufficient response or intolerance. Tapering schedule by reducing the dosage and prolonging the intervals between administrations was preferred by 73% of respondents. TPO-RA was considered a risk factor for thrombosis by only 35%, and 94% would administer TPO-RA in elderly patients also in the presence of other thrombotic risk factors. Thirty-three percent of respondents would withdraw TPO-RA in case of thrombosis. The TPORA administration has been reported to be preferred over anti-CD20 or splenectomy by about half of the participants due to the ongoing COVID-19 pandemic. Conclusions: Significant discrepancies in TPO-RA use emerged from the survey, and participants would appreciate consensus-based specific guidance on the practical use of TPO-RA. [ABSTRACT FROM AUTHOR]

Published
2023
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17. Practical recommendations for the management of patients with ITP during the COVID-19 pandemic

Author

Rodeghiero, Francesco, Cantoni, Silvia, Carli, Giuseppe, Carpenedo, Monica, Carrai, Valentina, Chiurazzi, Federico, De Stefano, Valerio, Santoro, Cristina, Siragusa, Sergio, Zaja, Francesco, Vianelli, Nicola, Rodeghiero, F., Cantoni, S., Carli, G., Carpenedo, M., Carrai, V., Chiurazzi, F., De Stefano, V., Santoro, C., Siragusa, S., Zaja, F., and Vianelli, N.

Subjects
Practical recommendations, hemic and lymphatic diseases, COVID-19, ITP, Review Article, Immune thrombocytopenia
Abstract

The current COVID-19 pandemic requires revisiting our current approach to major blood disorders, including ITP (Immune Thrombocytopenia), stirring up the production of several disease-specific practical guidelines. This report describes an updated version of consensus-based practical guidelines on the management of ITP, adapted to the Italian health system and social context. It highlights the role of the hematologist in offering guidance for choosing differentiated approaches in relation to specific circumstances and is intended to provide them with a useful tool for sharing the decision-making process with their patients. Probably, the greatest risk to avoid for a patient with suspected, ongoing or relapsed ITP - that is not severe enough to place him or her at risk for major bleeding - is to be infected in non-hospital and hospital healthcare settings. This risk must be carefully considered when adapting the diagnostic and therapeutic approach. More in detail, the document first addresses the appropriate management for COVID-19 negative patients with newly diagnosed ITP or who experience a relapse of previous ITP, according to first and second lines of treatment and then the management of COVID-19 positive patients according to their severity, from paucisymptomatic to those requiring admission to Intensive Cure Units (ICU). The pros and cons of the different treatments required to correct platelet count are discussed, as are some specific situations, including chronic ITP, splenectomy, thromboembolic complication and anti COVID-19 vaccination.

Published
2021

18. Real-world use of thrombopoietin receptor agonists in elderly patients with primary immune thrombocytopenia

Author

Palandri, Francesca, Rossi, Elena, Bartoletti, Daniela, Ferretti, Antonietta, Ruggeri, Marco, Lucchini, Elisa, Carrai, Valentina, Barcellini, Wilma, Patriarca, Andrea, Rivolti, Elena, Consoli, Ugo, Cantoni, Silvia, Oliva, Esther Natalie, Chiurazzi, Federico, Caocci, Giovanni, Giuffrida, Gaetano, Borchiellini, Alessandra, Auteri, Giuseppe, Baldacci, Erminia, Carli, Giuseppe, Nicolosi, Daniela, Sutto, Emanuele, Carpenedo, Monica, Cavo, Michele, Mazzucconi, Maria Gabriella, Zaja, Francesco, De Stefano, Valerio, Rodeghiero, Francesco, Vianelli, Nicola, Rossi, Elena (ORCID:0000-0002-7572-9379), De Stefano, Valerio (ORCID:0000-0002-5178-5827), Palandri, Francesca, Rossi, Elena, Bartoletti, Daniela, Ferretti, Antonietta, Ruggeri, Marco, Lucchini, Elisa, Carrai, Valentina, Barcellini, Wilma, Patriarca, Andrea, Rivolti, Elena, Consoli, Ugo, Cantoni, Silvia, Oliva, Esther Natalie, Chiurazzi, Federico, Caocci, Giovanni, Giuffrida, Gaetano, Borchiellini, Alessandra, Auteri, Giuseppe, Baldacci, Erminia, Carli, Giuseppe, Nicolosi, Daniela, Sutto, Emanuele, Carpenedo, Monica, Cavo, Michele, Mazzucconi, Maria Gabriella, Zaja, Francesco, De Stefano, Valerio, Rodeghiero, Francesco, Vianelli, Nicola, Rossi, Elena (ORCID:0000-0002-7572-9379), and De Stefano, Valerio (ORCID:0000-0002-5178-5827)

Abstract

The efficacy and safety of thrombopoietin-receptor agonists (TRAs) in elderly patients with primary immune thrombocytopenia (ITP) is uncertain. In 384 ITP patients treated with TRAs when aged ≥60 years, we investigated TRAs response and switch, thrombotic/hemorrhagic risk, and sustained responses off-treatment (SROT). After 3 months, 82.5% and 74.3% of eltrombopag and romiplostim-treated patients achieved a response, respectively (p=0.09); 66.7% maintained the response (median follow-up: 2.7 years). Eighty-five (22.2%) patients switched to the alternative TRA; while no cross-toxicity was observed, 83.3% of resistant patients had a response after the switch. During TRA, 34 major thromboses (3 fatal) and 14 major hemorrhages (none fatal) occurred in 18 and 10 patients, respectively, and were associated with thrombosis history (SHR: 2.04, p=0.05) and platelet count <20x109/L at TRA start (SHR: 1.69, p=0.04), respectively. A recurrent event occurred in 15.6% of patients surviving thrombosis, in all cases but one during persisting TRA treatment (incidence rate: 7.7 per 100 patient-years). All recurrences occurred in the absence of adequate antithrombotic secondary prophylaxis. Sixty-two (16.5%) responding patients discontinued TRA; 53 (13.8%) patients maintained SROT, which was associated with TRA discontinuation in complete response (p<0.001). Very old age (≥75, 41.1%) was associated with more frequent TRAs start in persistent/acute phase but not with response or thrombotic/hemorrhagic risk. TRAs are effective in elderly ITP patients, with no fatal haemorrhages and with SROT in a significant portion of patients; in patients with thrombosis history caution is warranted and a careful risk/benefit balance should be carried out.

Published
2021

20. Masked polycythemia Vera (mPV): Results of an international study

Author

Barbui, Tiziano, Thiele, Jürgen, Gisslinger, Heinz, Finazzi, Guido, Carobbio, Alessandra, Rumi, Elisa, Luigia Randi, Maria, Betozzi, Irene, Vannucchi, Alessandro M., Pieri, Lisa, Carrai, Valentina, Gisslinger, Bettina, Müllauer, Leonhard, Ruggeri, Marco, Rambaldi, Alessandro, and Tefferi, Ayalew

Published
2014
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21. Real-world use of thrombopoietin receptor agonists in older patients with primary immune thrombocytopenia

Author

Palandri, Francesca, primary, Rossi, Elena, additional, Bartoletti, Daniela, additional, Ferretti, Antonietta, additional, Ruggeri, Marco, additional, Lucchini, Elisa, additional, Carrai, Valentina, additional, Barcellini, Wilma, additional, Patriarca, Andrea, additional, Rivolti, Elena, additional, Consoli, Ugo, additional, Cantoni, Silvia, additional, Oliva, Esther Natalie, additional, Chiurazzi, Federico, additional, Caocci, Giovanni, additional, Giuffrida, Gaetano, additional, Borchiellini, Alessandra, additional, Auteri, Giuseppe, additional, Baldacci, Erminia, additional, Carli, Giuseppe, additional, Nicolosi, Daniela, additional, Sutto, Emanuele, additional, Carpenedo, Monica, additional, Cavo, Michele, additional, Mazzucconi, Maria Gabriella, additional, Zaja, Francesco, additional, De Stefano, Valerio, additional, Rodeghiero, Francesco, additional, and Vianelli, Nicola, additional

Published
2021
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23. Aggressive Disease Course of Multiple Myeloma with Concomitant ALK-Negative Anaplastic Large Cell Lymphoma: A Case Report with an Unusual Presentation

Author

Staderini, Michela, Mannelli, Lara, Antonioli, Elisabetta, Puccini, Benedetta, Berti, Valentina, Mungai, Francesco, Vergoni, Federica, Carrai, Valentina, Rigacci, Luigi, and Bosi, Alberto

Subjects
Article Subject, immune system diseases, hemic and lymphatic diseases
Abstract

ALK-negative anaplastic large cell lymphoma is a rare T-cell neoplasm with an aggressive course requiring prompt diagnostic work-up and treatment. Few cases of concomitant multiple myeloma and T-cell neoplasm are described in the literature, mainly regarding primary cutaneous anaplastic large cell lymphoma. We present the case of a 65-year-old man, simultaneously diagnosed with ALK-negative anaplastic large cell lymphoma with extranodal localization in the gastrocnemius muscle (stage 1AE) and IgG lambda multiple myeloma (ISS 2, Durie-Salmon stage 3A). Both diseases required therapeutic intervention due to the high proliferative index of lymphoma and the presence of bone lesions attributable to myeloma. The therapeutic program initially included chemotherapy (cyclophosphamide, doxorubicin, vincristine, etoposide, and prednisone; CHOEP), radiotherapy on the leg, bortezomib, and then consolidation with autologous hematopoietic stem cell transplantation. Despite being on bortezomib treatment and waiting for transplantation, the patient experienced an early myeloma progression that turned out to be refractory to second-line lenalidomide-based treatment. To our knowledge, this is the first case of concurrent diagnosis of extranodal ALK-negative anaplastic large cell lymphoma of the muscle and multiple myeloma. Simultaneous onset can be challenging for clinicians as both diseases may have an aggressive course requiring multiple treatments with increased risk of toxicity and complicated management.

Published
2020
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25. Native T1 Values and Cardiac Involvement in Patients with Thalassemia Major

Author

Pepe, Alessia, primary, Martini, Nicola, additional, De Luca, Antonio, additional, Positano, Vincenzo, additional, Pistoia, Laura, additional, Borsellino, Zelia, additional, Carrai, Valentina, additional, Sanna, Maria Grazia, additional, Bitti, Pier Paolo, additional, Gentili, Sara, additional, Maggio, Aurelio, additional, Sinagra, Gianfranco, additional, and Meloni, Antonella, additional

Published
2020
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28. Management of elderly patients with immune thrombocytopenia: Real-world evidence from 451 patients older than 60 years

Author

Palandri, Francesca, primary, Santoro, Cristina, additional, Carpenedo, Monica, additional, Cantoni, Silvia, additional, Barcellini, Wilma, additional, Carli, Giuseppe, additional, Carrai, Valentina, additional, Rossi, Elena, additional, Rivolti, Elena, additional, Lucchesi, Alessandro, additional, Rotondo, Francesco, additional, Baldacci, Erminia, additional, Auteri, Giuseppe, additional, Sutto, Emanuele, additional, Di Pietro, Christian, additional, Catani, Lucia, additional, Bartoletti, Daniela, additional, De Stefano, Valerio, additional, Ruggeri, Marco, additional, Mazzucconi, Maria Gabriella, additional, Cavo, Michele, additional, Rodeghiero, Francesco, additional, and Vianelli, Nicola, additional

Published
2020
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29. Pancreatic Iron and Glucidic Metabolism in Thalassemia Major

Author

Pepe, Alessia, primary, Pistoia, Laura, additional, Campisi, Saveria, additional, Sarli, Roberto, additional, Giovangrossi, Piera, additional, Guerrini, Giulia, additional, Mattei, Roberto, additional, Maggio, Aurelio, additional, Visceglie, Domenico, additional, Carrai, Valentina, additional, Peritore, Giuseppe, additional, Positano, Vincenzo, additional, and Meloni, Antonella, additional

Published
2019
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31. Real-Life Management of Immune Thrombocytopenia in the Elderly: A Multicentre Study on 526 Patients

Author

Palandri, Francesca, primary, Santoro, Cristina, additional, Carpenedo, Monica, additional, Silvia, Cantoni, additional, Barcellini, Wilma, additional, Carli, Giuseppe, additional, Carrai, Valentina, additional, Rossi, Elena, additional, Rivolti, Elena, additional, Lucchesi, Alessandro, additional, Rotondo, Francesco, additional, Auteri, Giuseppe, additional, Ruggeri, Marco, additional, Fusco, Alessio, additional, Baldacci, Erminia, additional, Catani, Lucia, additional, Bartoletti, Daniela, additional, Cavo, Michele, additional, De Stefano, Valerio, additional, Mazzucconi, Maria Gabriella, additional, Rodeghiero, Francesco, additional, and Vianelli, Nicola, additional

Published
2018
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32. Thrombopoietin receptor agonists for preparing adult patients with immune thrombocytopenia to splenectomy: results of a retrospective, observational GIMEMA study

Author

Zaja, Francesco, Barcellini, Wilma, Cantoni, Silvia, Carpenedo, Monica, Caparrotti, Giuseppe, Carrai, Valentina, Di Renzo, Nicola, Santoro, Cristina, Di Nicola, Massimo, Veneri, Dino, Simonetti, Federico, Liberati, Anna M., Ferla, Valeria, Paoloni, Francesca, Crea, Enrico, Volpetti, Stefano, Tuniz, Enrica, Fanin, Renato, Zaja, Francesco, Barcellini, Wilma, Cantoni, Silvia, Carpenedo, Monica, Caparrotti, Giuseppe, Carrai, Valentina, Di Renzo, Nicola, Santoro, Cristina, Di Nicola, Massimo, Veneri, Dino, Simonetti, Federico, Liberati, Anna M., Ferla, Valeria, Paoloni, Francesca, Crea, Enrico, Volpetti, Stefano, Tuniz, Enrica, and Fanin, Renato

Subjects
Male, Premedication, Drug Resistance, Adrenal Cortex Hormones, Adult, Aged, Aged, 80 and over, Benzoates, Combined Modality Therapy, Female, Humans, Hydrazines, Immunoglobulins, Intravenous, Italy, Middle Aged, Platelet Count, Portal Vein, Postoperative Complications, Preoperative Care, Pulmonary Embolism, Purpura, Thrombocytopenic, Idiopathic, Pyrazoles, Receptors, Fc, Receptors, Thrombopoietin, Recombinant Fusion Proteins, Retrospective Studies, Salvage Therapy, Thrombophilia, Thrombopoiesis, Thrombopoietin, Venous Thrombosis, Young Adult, Splenectomy, Hematology, Adrenal Cortex Hormone, Retrospective Studie, Receptors, Hydrazine, 80 and over, CIRRHOSIS, Fc, Idiopathic, LONG-TERM, PLATELET COUNT, ROMIPLOSTIM, ELTROMBOPAG, PURPURA, MANAGEMENT, EFFICACY, SAFETY, Thrombopoiesi, Intravenous, Human, Receptor, Intravenou, Immunoglobulins, Benzoate, Immunoglobulin, Venous Thrombosi, Purpura, Thrombocytopenic, Pyrazole, Postoperative Complication, Recombinant Fusion Protein
Abstract

In patients with immune thrombocytopenia (ITP) refractory to corticosteroids and intravenous immunoglobulins (IVIG), splenectomy may result at higher risk of peri-operative complications and, for this reason, potentially contraindicated. The thrombopoietin receptor agonists (TPO-RAs) romiplostim and eltrombopag have shown high therapeutic activity in primary ITP, but data of efficacy and safety regarding their use in preparation for splenectomy are missing. Thirty-one adult patients, median age 50 years, with corticosteroids and/or IVIG refractory persistent and chronic ITP who were treated with TPO-RAs (romiplostim= 24; eltrombopag= 7) with the aim to increase platelet count and allow a safer execution of splenectomy were retrospectively evaluated. Twenty-four patients (77%) responded to the use of TPO-RAs with a median platelet count that increased from 11 × 109/L before starting TPO-RAs to 114 × 109/L pre-splenectomy, but a concomitant treatment with corticosteroids and/or IVIG was required in 19 patients. Twenty-nine patients underwent splenectomy while two patients who responded to TPO-RAs subsequently refused surgery. Post-splenectomy complications were characterized by two Grade 3 thrombotic events (1 portal vein thrombosis in the patient with previous history of HCV hepatitis and 1 pulmonary embolism), with a platelet count at the time of thrombosis of 260 and 167 × 109/L, respectively and one Grade 3 infectious event. TPO-RAs may represent a therapeutic option to improve platelet count and reduce the risk of peri-operative complications in ITP candidates to splenectomy. An increased risk of post-splenectomy thromboembolic events cannot be ruled out and thromboprophylaxis with low-molecular weight heparin is generally recommended. © 2016 Wiley Periodicals, Inc.

Published
2015

34. Corrigendum to “Rapid infusions of human normal immunoglobulin 50 g/l are safe and well tolerated in immunodeficiencies and immune thrombocytopenia” [Int. Immunopharmacol. 44 (2017) 38–42]

Author

Spadaro, Giuseppe, primary, Vultaggio, Alessandra, additional, Bosi, Alberto, additional, Reichert, Dietmar, additional, Janssen, Jan, additional, Lamacchia, Donatella, additional, Nappi, Liliana, additional, Pecoraro, Antonio, additional, Milito, Cinzia, additional, Ferraro, Andrea, additional, Matucci, Andrea, additional, Bacchiarri, Francesca, additional, Carrai, Valentina, additional, Hibbeler, Azra, additional, Speckman, Elisabet, additional, Guarnieri, Chiara, additional, Bongiovanni, Serena, additional, and Quinti, Isabella, additional

Published
2018
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35. Alternate use of thrombopoietin receptor agonists in adult primary immune thrombocytopenia patients: A retrospective collaborative survey from Italian hematology centers

Author

Cantoni, Silvia, primary, Carpenedo, Monica, additional, Mazzucconi, Maria Gabriella, additional, De Stefano, Valerio, additional, Carrai, Valentina, additional, Ruggeri, Marco, additional, Specchia, Giorgina, additional, Vianelli, Nicola, additional, Pane, Fabrizio, additional, Consoli, Ugo, additional, Artoni, Andrea, additional, Zaja, Francesco, additional, D'adda, Mariella, additional, Visentin, Andrea, additional, Ferrara, Felicetto, additional, Barcellini, Wilma, additional, Caramazza, Domenica, additional, Baldacci, Erminia, additional, Rossi, Elena, additional, Ricco, Alessandra, additional, Ciminello, Angela, additional, Rodeghiero, Francesco, additional, Nichelatti, Michele, additional, and Cairoli, Roberto, additional

Published
2017
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36. Low Levels of Fruit Nitrogen as Drivers for the Evolution of Madagascar’s Primate Communities

Author

Donati, G., Santini, L., Eppley, Timothy M., Arrigo-Nelson, Summer J., Balestri, Michela, Boinski, Sue, Bollen, An, Bridgeman, LeAndra L., Campera, Marco, Carrai, Valentina, Chalise, Mukesh K., Derby Lewis, Abigail, Hohmann, Gottfried, Kinnaird, Margaret F., Koenig, Andreas, Kowalewski, Martin, Lahann, Petra, McLennan, Matthew R., Nekaris, Anna K. I., Nijman, Vincent, Norscia, Ivan, Ostner, Julia, Polowinsky, Sandra Y., Schülke, Oliver, Schwitzer, Christoph, Stevenson, Pablo R., Talebi, Mauricio G., Tan, Chia, Tomaschewski, Irene, Vogel, Erin R., Wright, Patricia C., Ganzhorn, Jörg U., Donati, G., Santini, L., Eppley, Timothy M., Arrigo-Nelson, Summer J., Balestri, Michela, Boinski, Sue, Bollen, An, Bridgeman, LeAndra L., Campera, Marco, Carrai, Valentina, Chalise, Mukesh K., Derby Lewis, Abigail, Hohmann, Gottfried, Kinnaird, Margaret F., Koenig, Andreas, Kowalewski, Martin, Lahann, Petra, McLennan, Matthew R., Nekaris, Anna K. I., Nijman, Vincent, Norscia, Ivan, Ostner, Julia, Polowinsky, Sandra Y., Schülke, Oliver, Schwitzer, Christoph, Stevenson, Pablo R., Talebi, Mauricio G., Tan, Chia, Tomaschewski, Irene, Vogel, Erin R., Wright, Patricia C., and Ganzhorn, Jörg U.

Abstract

Contains fulltext : 181106.pdf (publisher's version ) (Open Access)

Published
2017

37. Low levels of fruit nitrogen as drivers for the evolution of Madagascar’s primate communities

Author

Donati, Giuseppe, Santini, Luca, Eppley, Timothy M., Arrigo-Nelson, Summer J., Balestri, Michela, Boinski, Sue, Bollen, An, Bridgeman, LeAndra L., Campera, Marco, Carrai, Valentina, Chalise, Mukesh K., Derby Lewis, Abigail, Hohmann, Gottfried, Kinnaird, Margaret F., Koenig, Andreas, Kowalewski, Martin, Lahann, Petra, McLennan, Matthew R., Nekaris, Anna K. I., Nijman, Vincent, Norscia, Ivan, Ostner, Julia, Polowinsky, Sandra Y., Schülke, Oliver, Schwitzer, Christoph, Stevenson, Pablo R., Talebi, Mauricio G., Tan, Chia, Tomaschewski, Irene, Vogel, Erin R., Wright, Patricia C., Ganzhorn, Jörg U., Donati, Giuseppe, Santini, Luca, Eppley, Timothy M., Arrigo-Nelson, Summer J., Balestri, Michela, Boinski, Sue, Bollen, An, Bridgeman, LeAndra L., Campera, Marco, Carrai, Valentina, Chalise, Mukesh K., Derby Lewis, Abigail, Hohmann, Gottfried, Kinnaird, Margaret F., Koenig, Andreas, Kowalewski, Martin, Lahann, Petra, McLennan, Matthew R., Nekaris, Anna K. I., Nijman, Vincent, Norscia, Ivan, Ostner, Julia, Polowinsky, Sandra Y., Schülke, Oliver, Schwitzer, Christoph, Stevenson, Pablo R., Talebi, Mauricio G., Tan, Chia, Tomaschewski, Irene, Vogel, Erin R., Wright, Patricia C., and Ganzhorn, Jörg U.

Abstract

The uneven representation of frugivorous mammals and birds across tropical regions – high in the New World, low in Madagascar and intermediate in Africa and Asia – represents a long-standing enigma in ecology. Several hypotheses have been proposed to explain these differences but the ultimate drivers remain unclear. Here, we tested the hypothesis that fruits in Madagascar contain insufficient nitrogen to meet primate metabolic requirements, thus constraining the evolution of frugivory. We performed a global analysis of nitrogen in fruits consumed by primates, as collated from 79 studies. Our results showed that average frugivory among lemur communities was lower compared to New World and Asian-African primate communities. Fruits in Madagascar contain lower average nitrogen than those in the New World and Old World. Nitrogen content in the overall diets of primate species did not differ significantly between major taxonomic radiations. There is no relationship between fruit protein and the degree of frugivory among primates either globally or within regions, with the exception of Madagascar. This suggests that low protein availability in fruits influences current lemur communities to select for protein from other sources, whereas in the New World and Old World other factors are more significant in shaping primate communities.

Published
2017

38. Low Levels of Fruit Nitrogen as Drivers for the Evolution of Madagascar’s Primate Communities

Author

Donati, Giuseppe, primary, Santini, Luca, additional, Eppley, Timothy M., additional, Arrigo-Nelson, Summer J., additional, Balestri, Michela, additional, Boinski, Sue, additional, Bollen, An, additional, Bridgeman, LeAndra L., additional, Campera, Marco, additional, Carrai, Valentina, additional, Chalise, Mukesh K., additional, Derby Lewis, Abigail, additional, Hohmann, Gottfried, additional, Kinnaird, Margaret F., additional, Koenig, Andreas, additional, Kowalewski, Martin, additional, Lahann, Petra, additional, McLennan, Matthew R., additional, Nekaris, Anna K. I., additional, Nijman, Vincent, additional, Norscia, Ivan, additional, Ostner, Julia, additional, Polowinsky, Sandra Y., additional, Schülke, Oliver, additional, Schwitzer, Christoph, additional, Stevenson, Pablo R., additional, Talebi, Mauricio G., additional, Tan, Chia, additional, Tomaschewski, Irene, additional, Vogel, Erin R., additional, Wright, Patricia C., additional, and Ganzhorn, Jörg U., additional

Published
2017
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39. Rapid infusions of human normal immunoglobulin 50g/l are safe and well tolerated in immunodeficiencies and immune thrombocytopenia

Author

Spadaro, Giuseppe, primary, Vultaggio, Alessandra, additional, Alberto Bosi, A, additional, Reichert, Dietmar, additional, Janssen, Jan, additional, Lamacchia, Donatella, additional, Nappi, Liliana, additional, Pecoraro, Antonio, additional, Milito, Cinzia, additional, Ferraro, Andrea, additional, Matucci, Andrea, additional, Bacchiarri, Francesca, additional, Carrai, Valentina, additional, Hibbeler, Azra, additional, Speckman, Elisabet, additional, Guarnieri, Chiara, additional, Bongiovanni, Serena, additional, and Quinti, Isabella, additional

Published
2017
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41. Concomitant JAK2 mutated myeloproliferative neoplasms and hereditary hemochromatosis.

Author

Loscocco, Giuseppe G., Santi, Raffaella, Carrai, Valentina, Coltro, Giacomo, Mannelli, Francesco, Guglielmelli, Paola, and Vannucchi, Alessandro M.

Subjects
HEMOCHROMATOSIS, GENETIC mutation, PHLEBOTOMY, FERRITIN, IRON, MYELOPROLIFERATIVE neoplasms, IRON in the body, JANUS kinases, TREATMENT effectiveness, HEMATOLOGIC malignancies
Abstract

A case study of 68-year-old man is presented with the previous unremarkable medical history was referred to Institution for hyperferritinimemia. Topics include examines physical examination revealed splenomegaly with spleen palpable at several cm from the left costal margin and considered laboratory tests showed normal blood count, a mild increase of total bilirubin and serum lactate dehydrogenase.

Published
2022
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42. The importance of protein in leaf selection of folivorous primates

Author

Ganzhorn, Joerg U., primary, Arrigo- Nelson, Summer J., additional, Carrai, Valentina, additional, Chalise, Mukesh K., additional, Donati, Giuseppe, additional, Droescher, Iris, additional, Eppley, Timothy M., additional, Irwin, Mitchell T., additional, Koch, Flávia, additional, Koenig, Andreas, additional, Kowalewski, Martin M., additional, Mowry, Christopher B., additional, Patel, Erik R., additional, Pichon, Claire, additional, Ralison, Jose, additional, Reisdorff, Christoph, additional, Simmen, Bruno, additional, Stalenberg, Eleanor, additional, Starrs, Danswell, additional, Terboven, Juana, additional, Wright, Patricia C., additional, and Foley, William J., additional

Published
2016
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46. The importance of protein in leaf selection of folivorous primates.

Author

Ganzhorn, Joerg U., Arrigo‐ Nelson, Summer J., Carrai, Valentina, Chalise, Mukesh K., Donati, Giuseppe, Droescher, Iris, Eppley, Timothy M., Irwin, Mitchell T., Koch, Flávia, Koenig, Andreas, Kowalewski, Martin M., Mowry, Christopher B., Patel, Erik R., Pichon, Claire, Ralison, Jose, Reisdorff, Christoph, Simmen, Bruno, Stalenberg, Eleanor, Starrs, Danswell, and Terboven, Juana

Subjects
PROTEINS in animal nutrition, FOLIVORES, ANIMAL nutrition, FIBER in animal nutrition, PRIMATE feeding habits
Abstract

Protein limitation has been considered a key factor in hypotheses on the evolution of life history and animal communities, suggesting that animals should prioritize protein in their food choice. This contrasts with the limited support that food selection studies have provided for such a priority in nonhuman primates, particularly for folivores. Here, we suggest that this discrepancy can be resolved if folivores only need to select for high protein leaves when average protein concentration in the habitat is low. To test the prediction, we applied meta-analyses to analyze published and unpublished results of food selection for protein and fiber concentrations from 24 studies (some with multiple species) of folivorous primates. To counter potential methodological flaws, we differentiated between methods analyzing total nitrogen and soluble protein concentrations. We used a meta-analysis to test for the effect of protein on food selection by primates and found a significant effect of soluble protein concentrations, but a non-significant effect for total nitrogen. Furthermore, selection for soluble protein was reinforced in forests where protein was less available. Selection for low fiber content was significant but unrelated to the fiber concentrations in representative leaf samples of a given forest. There was no relationship (either negative or positive) between the concentration of protein and fiber in the food or in representative samples of leaves. Overall our study suggests that protein selection is influenced by the protein availability in the environment, explaining the sometimes contradictory results in previous studies on protein selection. Am. J. Primatol. 79:e22550, 2017. © 2016 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]

Published
2017
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47. Survival and Risk of Leukemic transformation in Essential Thrombocythemia Are Significantly Influenced by Accurate Morphologic Diagnosis: An International Study on 1,104 Patients

Author

Barbui, Tiziano, Thiele, Juergen, Passamonti, Francesco, Rumi, Elisa, Boveri, Emanuela, Ruggeri, Marco, Rodeghiero, Francesco, D'Amore, Emanuele, Randi, Maria Luigia, Bertozzi, Irene, Marino, Filippo, Vannucchi, Alessandro M., Antonioli, Elisabetta, Carrai, Valentina, Gisslinger, Heinz, Buxhofer-Ausch, Veronika, Muellauer, Leonhard, Carobbio, Alessandra, Gianatti, Andrea, Gangat, Naseema, Hanson, Curtis A., Tefferi, Ayalew, Barbui, Tiziano, Thiele, Juergen, Passamonti, Francesco, Rumi, Elisa, Boveri, Emanuela, Ruggeri, Marco, Rodeghiero, Francesco, D'Amore, Emanuele, Randi, Maria Luigia, Bertozzi, Irene, Marino, Filippo, Vannucchi, Alessandro M., Antonioli, Elisabetta, Carrai, Valentina, Gisslinger, Heinz, Buxhofer-Ausch, Veronika, Muellauer, Leonhard, Carobbio, Alessandra, Gianatti, Andrea, Gangat, Naseema, Hanson, Curtis A., and Tefferi, Ayalew

Published
2010

48. Masked polycythemia Vera (mPV): Results of an international study

Author

Barbui, Tiziano, primary, Thiele, Jürgen, additional, Gisslinger, Heinz, additional, Finazzi, Guido, additional, Carobbio, Alessandra, additional, Rumi, Elisa, additional, Luigia Randi, Maria, additional, Betozzi, Irene, additional, Vannucchi, Alessandro M., additional, Pieri, Lisa, additional, Carrai, Valentina, additional, Gisslinger, Bettina, additional, Müllauer, Leonhard, additional, Ruggeri, Marco, additional, Rambaldi, Alessandro, additional, and Tefferi, Ayalew, additional

Published
2013
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49. Immunohistochemistry analysis of bone marrow biopsies in multiple sclerosis patients undergoing autologous haematopoietic stem cells transplantation

Author

Carrai, Valentina, primary, Donnini, Irene, additional, Mazzanti, Benedetta, additional, Alterini, Renato, additional, Amato, Maria Pia, additional, Barilaro, Alessandro, additional, Bosi, Alberto, additional, Massacesi, Luca, additional, Portaccio, Emilio, additional, Repice, Anna Maria, additional, Rotunno, Giada, additional, and Saccardi, Riccardo, additional

Published
2013
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50. Characteristics and clinical correlates of MPL 515W>L/K mutation in essential thrombocythemia

Author

Vannucchi, Alessandro M., Antonioli, Elisabetta, Guglielmelli, Paola, Pancrazzi, Alessandro, Guerini, Vittoria, Barosi, Giovanni, Ruggeri, Marco, Specchia, Giorgina, Lo-Coco, Francesco, Delaini, Federica, Villani, Laura, Finotto, Silvia, Ammatuna, Emanuele, Alterini, Renato, Carrai, Valentina, Capaccioli, Gloria, Lollo, Simonetta Di, Liso, Vincenzo, Rambaldi, Alessandro, Bosi, Alberto, and Barbui, Tiziano

Published
2008
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