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16 results on '"Carr, Ed"'

2. Vitamin C: Current Concepts in Human Physiology.

Author

Anitra C. Carr (Ed.) and Ramesh Natarajan (Ed.)

Subjects
Ascorbate, Cancer, Cardiovascular Dysfunction, Cognition, Inflammation, Intravenous, Mood, Pharmacological, Quality of Life, Safety, Vitamin C
Abstract

Summary: ca. 200 words; this text will present the book in all promotional forms (e.g. flyers). Please describe the book in straightforward and consumer-friendly terms. [Vitamin C is synthesized by almost all animals. However, for humans, it is a vitamin that needs constant replenishment in the diet. While its role as an anti-oxidant and for preventing scurvy have been known for a long time, novel functions and unrecognized associations continue to be identified for this enigmatic molecule. In the past decade, new details have emerged regarding differences in its uptake by oral and intravenous modes. While vitamin C deficiency remains largely unknown and poorly addressed in many segments of the population, novel pharmacological roles for high-dose, intravenous vitamin C in many disease states have now been postulated and investigated. This has shifted its role in health and disease from the long-perceived notion as merely a vitamin and an anti-oxidant to a pleiotropic molecule with a broad anti-inflammatory, epigenetic, and anti-cancer profile. This Special Issue comprises original research papers and reviews on vitamin C metabolism and function that relate to the following topics: understanding its role in the modulation of inflammation and immunity, therapeutic applications and safety of pharmacological ascorbate in disease, and the emerging role of vitamin C as a pleiotropic modulator of critical care illness and cancer.]

6. Alamogordo is hot, Hot, Hot!

Author

Carr, Ed

Subjects
Alamogordo, New Mexico -- Economic aspects, Real estate development -- Forecasts and trends, Market trend/market analysis, Business, Business, regional
Abstract

Alamogordo's economy is rising as residential builders are setting their sights on high-end homes, increasing the average value of a new house by 26.4% from those permitted in May 2004 versus those permitted in May 2005. While the numbers of houses being built are modest, the rise in average price proves a growing demand for more high-end amenities.

Published
2005

7. The Governor focuses on Otero County

Author

Carr, Ed

Subjects
National defense -- Management, Economic development -- Analysis, Economic development -- New Mexico, Company business management, Business, Business, regional
Abstract

The business climate in the 21st century is expected to be dominated by Otero County's federal interests in national defense, desalination, trade with Mexico, forestry, and energy. The Governor gives a unique perspective of the role of Otero County in New Mexico's future by his past experience at the national level as a U.S. Representative, Ambassador to the United Nations and Secretary of Energy.

Published
2004

8. Make sure the land agent is on your side

Author

Carr, Ed

Subjects
Real estate agents and brokers -- Services, Commercial leases -- Management, Fiduciary duties -- Laws, regulations and rules, Business, Business, regional
Published
1997

9. '...state and local taxes are the killer...' (Long Island's economic problems)

Author

Carr, Ed

Subjects
Long Island (New York) -- Tax policy, Long Island Lighting Co. -- Taxation -- 00305285, Electric utilities -- Taxation, Local taxation -- Economic aspects, State taxation -- Economic aspects, Business, Business, regional
Abstract

Exorbitant state and local taxes are the primary reasons behind Long Island's (LI) economic woes. LI residents pay the highest property and sales taxes in the US. If New York state government really wants to reduce Long Island Lighting Co.'s (LILCO) rates, it should reduce the utility's tax burden. Cutting LILCO's taxes to the national average would bring about an immediate 11% rate reduction., Last week, the LI Power Authority presented a comprehensive plan to break up the LI Lighting Co. The plan received mixed reviews from the media and Wall Street, and is [...]

Published
1995

12. LETTERS.

Author

John, Steve St., Martin, Bonnie Holland, Snyder, Deborah, Welch, Karen, Wilson, S. J., Daugherty, Annieg, Craig, Kathy, Carr, Ed, Monroe, Russ, Dees, Joan, Wallius, Richard Scott, Wolfe, Rose J., Beaver, Kathy Harrison, Hogan, Michael, and Crofts, Dave

Published
2017

15. Letters.

Author

Sugerman, Leonard R. and Carr, Ed

Subjects
LETTERS to the editor, PERIODICALS, BUSINESS, CITIES & towns
Abstract

Presents letters to the editor about the "New Mexico Business Journal." Request to continue recognizing southern New Mexico; Comment on the section "The Back Page."

Published
2005

16. Gp91(phox) contributes to the development of experimental inflammatory bowel disease.

Author

Bao S, Carr ED, Xu YH, and Hunt NH

Subjects
Animals, Colon immunology, Colon metabolism, Colon pathology, Dextran Sulfate, Endothelium, Vascular immunology, Endothelium, Vascular pathology, Inflammation, Inflammatory Bowel Diseases chemically induced, Inflammatory Bowel Diseases pathology, Interleukin-10 biosynthesis, Interleukin-6 biosynthesis, Intestines immunology, Intestines pathology, Membrane Glycoproteins genetics, Mice, Mice, Inbred C57BL, Mice, Knockout, NADPH Oxidase 2, NADPH Oxidases genetics, Neutrophils physiology, Respiratory Burst, Inflammatory Bowel Diseases immunology, Inflammatory Bowel Diseases metabolism, Intestinal Mucosa metabolism, Membrane Glycoproteins metabolism, NADPH Oxidases metabolism
Abstract

Inflammatory bowel disease (IBD) is related to dysfunction of intestinal immunity. Neutrophils have an important role in innate immunity via the oxidative burst, using the p47phox- and gp91(phox)-containing NAD(P)H oxidase known as Nox2. In dextran sulphate sodium (DSS)-induced colitis, no significant difference in inflammation between p47(phox-/-) and wild-type (WT) mice was reported, but there was improved endothelium-dependent arteriolar dilation in gp91(phox-/-) mice, compared with that in WT mice. Gp91(phox) and p47 (phox) are not only essential components of phagocyte Nox2, but also have roles in other enzymes. Thus the differences in response of their respective gene knockout mice to DSS challenge are not completely unexpected, but need further investigation. The clinicopathological changes and immunological responses to DSS challenge have not been fully described in gp91(phox-/-) mice. Thus we treated WT and gp91(phox-/-) mice with 2.5% DSS for 7 days. The gp91(phox-/-) mice developed less severe colitis than WT mice following DSS treatment, reflected by a smaller body weight loss, less rectal bleeding and fewer histopathological changes. Less colonic myeloperoxidase was observed in gp91(phox-/-), compared with WT mice, following DSS challenge, correlating with interleukin (IL)-6 production. IL-10 was upregulated in both gp91(phox-/-) and WT mice, but was significantly higher in the latter, following 7 days DSS challenge. These results suggest that gp91(phox-/-) mice are less susceptible to acute DSS-induced colitis, possibly because of a reduced oxidative burst in the intestine and, consequently, less tissue damage.

Published
2011
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