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921 results on '"Carpentier, Yvon"'

2. Impact of a Food Rebalancing Program Associated with Plant-Derived Food Supplements on the Biometric, Behavioral, and Biological Parameters of Obese Subjects

Author

Houben, Jean-Jacques, Carpentier, Yvon, Paulissen, Genevieve, Snick, Georges Van, Soetewey, Antoine, Houben, Jean-Jacques, Carpentier, Yvon, Paulissen, Genevieve, Snick, Georges Van, and Soetewey, Antoine

Abstract

Between 2021 and 2023, the Scientific Council of Dietplus®, a group specialized in overweight and obesity management, conducted a clinical study on 170 volunteer subjects with a BMI > 29 Kg/m2 consecutively recruited. The Dietplus® program comprises nutritional education, intensive, personalized coaching, and consuming food supplements rich in plant derivatives. The aim of this study was to assess the effect of the Dietplus® program on biometric, behavioral, and biological parameters. A control group of 30 obese patients was followed for a similar 12-week period. Mean weight loss reached 9 ± 2.1 kg in the Dietplus® test group versus a 1 ± 0.1 kg weight gain in the control group. Excess weight loss reached 33 ± 13%, and fat mass loss was 7.6% (p < 0.001); waist circumference was reduced by 30%. Quality of Life, Nutriscore, and Prochaska di Clemente scale significantly improved (p < 0.001). Biological parameters showed substantial improvements in the carbohydrate profile and insulin resistance (HOMA index) and in the lipid profile with lower plasma triglyceride (p < 0.01) and VLDL (p < 0.01) concentrations. Inflammatory parameters (orosomucoid, ultrasensitive C-reactive protein, and PINI indices) were also substantially reduced. These results indicate a substantial benefit in subjects who followed the Dietplus® program. (Dietplus® 116 Rue Robert Bunsen, 57460 Behren-lès-Forbach, France is active in France Belgium and Spain. Plant Derived Food Supplements are produced in France). Indeed, improvements were observed in all biometric, behavioral, and metabolic parameters., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2023

19. CD36 and proteoglycan-mediated pathways for (n-3) fatty acid-enriched triglyceride-rich particle blood clearance in mouse models in vivo and in peritoneal macrophages in vitro

Author

Densupsoontorn, Narumon, Carpentier, Yvon A., Racine, Radjini, Murray, Faith M., Seo, Toru, Ramakrishnan, Rajasekhar, and Deckelbaum, Richard J.

Subjects
Membrane proteins -- Properties, Membrane proteins -- Models, Proteoglycans -- Properties, Proteoglycans -- Models, Triglycerides -- Properties, Triglycerides -- Models, Biological transport -- Models, Macrophages -- Properties, Macrophages -- Models, Food/cooking/nutrition
Abstract

Because the mechanisms of (n-3) fatty acid-enriched triglyceride-rich particle [(n-3)-TGRP] uptake are not well characterized, we questioned whether (n-3)-TGRP are removed via 'nonclassical' pathways, e.g., pathways other than an LDL receptor and/or involving apolipoprotein E (apoE). Chytomicron-sized model (n-3)-TGRP labeled with [[sup.3]H]cholesteryl ether were injected into wild-type (WT) and CD36 knockout (CD36-/-) mice at low, nonsaturating and high, saturating doses. Blood clearance of (n-3)-TGRP was determined by calculating fractional catabolic rates. At saturating doses, blood clearance of (n-3)-TGRP was slower in CD36-/- mice relative to WT mice, suggesting that in part CD36 contributes to (n-3)-TGRP uptake. To further examine the potential nonclassical clearance pathways, peritoneal-elicited macrophages from WT and CD36-/- mice were incubated with (n-3)-TGRP in the presence of apoE, lactoferrin, and/or sodium chlorate. Cellular (n-3)-TGRP uptake was measured to test the roles of apoE-mediated pathways and/or proteoglycans. ApoE-mediated pathways compensated in part for defective (n-3)-TGRP uptake in CD36-/- cells. Lactoferrin decreased (n-3)-TGRP uptake in the presence of apoE. Inhibition of cell proteoglycan synthesis by chlorate reduced (n-3)-TGRP uptake in both groups of macrophages, and chlorate effects were independent of apoE. We conclude that although CD36 is involved, it is not the primary contributor to the blood clearance of (n-3)-TGRP. The removal of (n-3)-TGRP likely relies more on nonclassical pathways, such as proteoglycan-mediated pathways.

Published
2008

25. Blood clearance kinetics and organ delivery of medium-chain triglyceride and fish oil-containing lipid emulsions: Comparing different animal species

Author

Hu, Chengming, Ding, Huanzhong, Zhuang, Qiulin, Llanos, Pierre, Pillay, Thivashnee, Hernandez, Carlo, Carpentier, Yvon, Deckelbaum, Richard J., Chang, Chuchun, Hu, Chengming, Ding, Huanzhong, Zhuang, Qiulin, Llanos, Pierre, Pillay, Thivashnee, Hernandez, Carlo, Carpentier, Yvon, Deckelbaum, Richard J., and Chang, Chuchun

Abstract

Background & aims: Medium-chain triglycerides (TG) (MCT) and fish oil (FO) TG are incorporated as the core TG component into intravenous (IV) lipid emulsions for infusion in parenteral nutrition. Bolus injections of IV emulsions, on the other hand, have emerged as a novel therapeutic approach to treat various acute disorders. However, intravascular metabolism and organ delivery of acute IV injection of emulsions containing both MCT and FO are not fully defined, nor have they been characterized across common experimental animal models. We characterized and compared blood clearance kinetics and organ distribution of bolus injections of MCT/FO emulsions among different animal species. We also examined whether sex differences or feeding status can affect catabolic properties of MCT/FO lipid emulsions. Design: Blood clearance rates of lipid emulsions with specific TG composition were compared in rats IV injected with [3H]cholesteryl hexadecyl ether labeled pure n-6 long-chain (LCT) and n-3 FO TG lipid emulsions, or emulsions containing MCT and FO at different ratios (wt/wt), which include 8:2 (80% MCT: 20% FO), 5:4:1 (50% MCT: 40% LCT: 10% FO) and SMOF (30% LCT: 30% MCT: 25% olive oil: 10% FO). Dose-response effects (0.016 mg–1.6 mg TG/g body weight) of the MCT/FO 8:2 emulsions on blood clearance properties and organ delivery were determined in both mice and rats. Blood clearance kinetics and organ uptake of MCT/FO 8:2 emulsions were compared between male and female rats and between fed and fasted rats. Changes in plasma lipid profiles after acute injections of MCT/FO 8:2 lipid emulsion at different doses (0.043, 0.133, and 0.4 mg TG/g body weight) were characterized in non-human primates (Cynomolgus monkeys). Results: MCT/FO 8:2 emulsion was cleared faster in rats when compared with other emulsions with different TG contents. Mice had faster blood clearance and higher fractional catabolic rates (FCR) when compared with the rats injected with MCT/FO 8:2 emulsions regardl, SCOPUS: ar.j, DecretOANoAutActif, info:eu-repo/semantics/published

Published
2020

26. Triglycerides in fish oil affect the blood clearance of lipid emulsions containing long- and medium-chain triglycerides in mice

Author

Qi, Kemin, Seo, Toru, Jiang, Zaifang, Carpentier, Yvon A., and Deckelbaum, Richard J.

Subjects
Fish oils -- Nutritional aspects, Fish oils -- Health aspects, Fish oils -- Research, Triglycerides -- Health aspects, Triglycerides -- Research, Food/cooking/nutrition
Abstract

Lipid emulsions containing long-chain triglycerides (LCT) and medium chain triglycerides (MCT) are widely used in parenteral nutrition. Recently, fish oil (FO) triglyceride (TG)-derived emulsions are considered therapeutic because of their many beneficial biological modulatory actions. We investigated in mice whether adding 10% FO to an intravenous lipid emulsion with MCT and LCT (MCT:LCT:FO -50:40:10% by wt) would affect particle blood clearance and tissue targeting in comparison to LCT (100% by wt) and MCT:LCT (50:50% by wt) emulsions. The 3 emulsions were labeled with [[sup.3]H] cholesteryl oleoyl ether and administered by bolus injection (400 [micro]g TG/mouse) to C57BL/6J mice. Contributions of LDL receptor (LDL-R) and LDL-R-related protein to emulsion catabolism were assessed using LDL-R-deficient mice and preinjection of lactoferrin, and the effects of lipoprotein lipase (LPL) were determined by preinjection of heparin and Triton WR 1339. Although fractional catabolic rates did not differ among the 3 emulsions, blood removal at each time point after injection was greater for MCT:LCT:FO particles due to their higher initial margination volume. Compared with MCT:LCT and LCT emulsions, patterns of tissue uptake of the MCT:LCT:FO emulsions were different, e.g. MCT:LCT:FO emulsion particle uptake was lower in heart, adipose tissue, and muscle, and higher in lung, and the removal of MCT:LCT:FO emulsion particles was less dependent on LPL, LDL-R, and lactoferrin-sensitive pathways. These data suggest that the addition of a low percentage of FO to MCT:LCT emulsions substantially changes their particle clearance and tissue uptake mechanisms.

Published
2006

34. Omega-3 triglycerides modify blood clearance and tissue targeting pathways of lipid emulsions

Author

Qi, Kemin, Seo, Toru, Al-Haideri, Maysoon, Worgall, Tilla S., Vogel, Tikva, Carpentier, Yvon A., and Deckelbaum, Richard J.

Subjects
Omega-3 fatty acids -- Physiological aspects, Triglycerides -- Physiological aspects, Blood lipids -- Physiological aspects, Lipid metabolism -- Physiological aspects, Biological sciences, Chemistry
Abstract

Results show that omega-3 rich triglycerides emulsion particles clear faster from blood, reach different tisue targets and exhibit different metabolic pathways than that of omega-6 triglycerides emulsions in mice. The clearance of chylomicron-sized omega-3 triglyceride emulsions is independent of apolipoprotein E, low-density lipoprotein-receptor, and lactoferrin-sensitive pathways.

Published
2002

44. Reply to E Oda

Author

Carpentier, Yvon A, Portois, Laurence, and Malaisse, Willy J

Published
2007

48. Effects of particle size on cell uptake of model triglyceride-rich particles with and without apoprotein E

Author

Granot, Esther, Schwiegelshohn, Bettina, Tabas, Ira, Gorecki, Marian, Vogel, Tikva, Carpentier, Yvon A., and Deckelbaum, Richard J.

Subjects
Particles -- Physiological aspects, Cell physiology -- Analysis, Apoprotein -- Analysis, Biological sciences, Chemistry
Abstract

A study in J-774 macrophages and fibroblasts of the effect of apoprotein E (apo E) on the cell intake of VLDL-size and IDL-size triacylglycerol-phospholipid emulsion particles reveals that cell intake of both size emulsion particles are enhanced by apo E. Cell intake of larger particles is greater than the intake of IDL-size particles. Particle intake in macrophages is greater than in fibroblasts. A non-receptor-mediated cell intake of VLDL-size and IDL-size particles is observed at physiological concentrations of triglyceride-rich particles.

Published
1994

49. Long-and medium-chain triacylglycerols in neutral lipid-exchange processes with human plasma low-density lipoproteins

Author

Richelle, Myriam, Carpentier, Yvon A., and Deckelbaum, Richard J.

Subjects
Triglycerides -- Research, Phospholipids -- Analysis, Biological sciences, Chemistry
Abstract

Comparison of in vitro transfer of triacylglycerols and cholesteryl esters between phospholipid stabilized emulsions enables an analysis of different molecular compounds of triacylglycerols. Triacylglycerols in neutral lipid exchange mechanisms are used in this analysis. Medium-chain and long-chain triacylglycerols are used for the incubations.

Published
1994

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