15 results on '"Carpagnano, Elisiana"'
Search Results
2. Economic impact of mepolizumab in uncontrolled severe eosinophilic asthma, in real life
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Guarnieri, Gabriella, Patella, Vincenzo, Maria Pia, Foschino Barbaro, Carpagnano, Elisiana, Colle, Anna del, Scioscia, Giulia, Gerolamo, Pelaia, Paggiaro, Pierluigi, Latorre, Manuela, Puggioni, Francesca, Racca, Francesca, Favero, Elisabetta, Iannacone, Sandra, Savi, Eleonora, Montagni, Marcello, Camiciottoli, Gianna, Allegrini, Chiara, Spadaro, Giuseppe, Detoraki, Caterina, Galeone, Carla, Ruggiero, Patrizia, Yacoub, Monna Rita, Berti, Alvise, Colombo, Gisella, Scichilone, Nicola, Durante, Carmen, Costantino, Maria Teresa, Roncallo, Chiara, Braschi, Mariachiara, Blasi, Francesco, D'Adda, Alice, Ridolo, Erminia, Triggiani, Massimo, Parente, Roberta, Maria, D'Amato, Verrillo, Maria Vittoria, Cristina, Zappa Maria, Lilli, Marianna, Crimi, Nunzio, Bonavia, Marco, Corsico, Angelo Guido, Grosso, Amelia, Del Giacco, Stefano, Deidda, Margherita, Ricciardi, Luisa, Isola, Stefania, Cicero, Francesca, Amato, Giuliana, Vita, Federica, Spanevello, Antonio, Pignatti, Patrizia, Cherubino, Francesca, Visca, Dina, Aletti, Eleonora, Massimo Ricciardolo, Fabio Luigi, Anna Carriero, Vitina Maria, Bertolini, Francesca, Santus, Pierachille, Barlassina, Roberta, Airoldi, Andrea, Guida, Giuseppe, Eleonora, Nucera, Aruanno, Arianna, Rizzi, Angela, Caruso, Cristiano, Colantuono, Stefania, Arcolaci, Alessandra, Vianello, Andrea, Bianchi, Fulvia Chieco, Marchi, Maria Rita, Centanni, Stefano, Luraschi, Simone, Ruggeri, Silvia, Rinaldo, Rocco, Parazzini, Elena, Calabrese, Cecilia, Flora, Martina, Cosmi, Lorenzo, Di Pietro, Linda, Maggi, Enrico, Pini, Laura, Macchia, Luigi, Di Bona, Danilo, Richeldi, Luca, Condoluci, Carola, Fuso, Leonello, Bonini, Matteo, Farsi, Alessandro, Carli, Giulia, Montuschi, Paolo, Santini, Giuseppe, Conte, Maria Elisabetta, Turchet, Elisa, Barbetta, Carlo, Mazza, Francesco, D'Alo, Simona, Pucci, Stefano, Caiaffa, Maria Filomena, Minenna, Elena, D'Elia, Luciana, Pasculli, Carlo, Viviano, Vittorio, Tarsia, Paolo, Rolo, Joyce, Di Proietto, Mariacarmela, Lo Cicero, Salvatore, Bagnasco, Diego, Povero, Massimiliano, Pradelli, Lorenzo, Brussino, Luisa, Rolla, Giovanni, Caminati, Marco, Menzella, Francesco, Heffler, Enrico, Canonica, Giorgio Walter, Senna, Gianenrico, Milanese, Manlio, Lombardi, Carlo, Bucca, Caterina, Manfredi, Andrea, Canevari, Rikki Frank, and Passalacqua, Giovanni
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- 2021
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3. Relationship between oral lesions and severe SARS‐CoV‐2 infection in intensive care unit patients.
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Favia, Gianfranco, Barile, Giuseppe, Tempesta, Angela, Copelli, Chiara, Novielli, Gianluigi, Dell'Olio, Fabio, Capodiferro, Saverio, Spirito, Francesca, Brienza, Nicola, Ribezzi, Mario, Vestito, Maria Concetta, Corriero, Alberto, Carpagnano, Elisiana, Moschetta, Antonio, Chironna, Maria, Loconsole, Daniela, Centrone, Francesca, Quadri, Mir Faeq Ali, Tartaglia, Gianluca Martino, and Limongelli, Luisa
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ORAL diseases ,ODDS ratio ,INTENSIVE care units ,AUTOIMMUNE diseases ,EPIDEMICS ,COVID-19 ,DISEASE progression - Abstract
Objective: Oral lesions received increased attention as likely new signs or secondary manifestations of COVID‐19. Therefore, we clinically examined oral cavity of patients with COVID‐19 and investigated oral lesions and patient comorbidities as possible risk factors of COVID‐19 disease outcome. Methods: From January to March 2022, a prospective study was conducted by recruiting all COVID‐19 patients admitted to the Intensive Care Unit and Respiratory Intensive Care Unit of Maxi‐Emergencies Hospital in Bari, Italy. Results: From the enrolled 103 COVID‐19 patients, 46.6% were females and 53.4% were males. Findings show that risk of presenting with severe COVID‐19 disease was higher in patients who developed oral lesions related to COVID‐19 than those with no oral lesions (RR = 7.998, p =.002). Next, patients with concomitant autoimmune diseases were at higher risk of a negative COVID‐19 disease outcome than those without comorbidities (OR = 8.838, p =.026). Conclusions: COVID‐19‐related lesions of oral mucosa should not be ignored as they can be early and easily detectable signs of severe COVID‐19 disease condition, thus, serving as a prevention measure for any potential unfortunate event. Findings of this study, without implying causation, offer a direction for future investigations that aim to confirm the presence of specific oral lesions in COVID‐19 patients as signs of severe disease progression. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Sputum and exhaled breath analysis
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Pignatti, Patrizia, primary, Visca, Dina, additional, Carpagnano, Elisiana, additional, Cherubino, Francesca, additional, and Spanevello, Antonio, additional
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- 2019
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5. Relationship Between Oral Lesions and Severe SARS‐CoV ‐2 Infection in Intensive Care Unit Patients
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Favia, Gianfranco, primary, Barile, Giuseppe, additional, Tempesta, Angela, additional, Copelli, Chiara, additional, Novielli, Gianluigi, additional, Dell’Olio, Fabio, additional, Capodiferro, Saverio, additional, Spirito, Francesca, additional, Brienza, Nicola, additional, Ribezzi, Mario, additional, Vestito, Maria Concetta, additional, Corriero, Alberto, additional, Carpagnano, Elisiana, additional, Moschetta, Antonio, additional, Chironna, Maria, additional, Loconsole, Daniela, additional, Centrone, Francesca, additional, Quadri, Mir Faeq Ali, additional, Tartaglia, Gianluca Martino, additional, and Limongelli, Luisa, additional
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- 2023
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6. Effects of anti‐IL5 biological treatments on blood IgE levels in severe asthmatic patients: A real‐life multicentre study (BIONIGE)
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Contoli, Marco, primary, Santus, Pierachille, additional, Menzella, Francesco, additional, Rocchi, Cindy, additional, Radovanovic, Dejan, additional, Baraldi, Federico, additional, Martelli, Chiara, additional, Casanova, Serena, additional, Barbetta, Carlo, additional, Micheletto, Claudio, additional, Scichilone, Nicola, additional, Beghè, Bianca, additional, Carpagnano, Elisiana, additional, and Papi, Alberto, additional
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- 2022
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7. Effect of Single Session Receptive Music Therapy on Anxiety and Vital Parameters in Hospitalized Covid-19 Patients: A Randomized Controlled Trial.
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Giordano, Filippo, primary, Losurdo, Antonella, additional, Quaranta, Vitaliano, additional, Campobasso, Nicla, additional, Daleno, Antonio, additional, Carpagnano, Elisiana, additional, Gesualdo, Loreto, additional, Moschetta, Antonio, additional, and Brienza, Nicola, additional
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- 2021
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8. BIOLOGICS SWITCH IN SEVERE EOSINOPHILIC ASTHMA
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Caminati, Marco, primary, Guarnieri, Gabriella, additional, Bagnasco, Diego, additional, Chieco Bianchi, Fulvia, additional, Carpagnano, Elisiana, additional, Maule, Matteo, additional, Molena, Beatrice, additional, Pelaia, Girolamo, additional, Pini, Laura, additional, Senna, Gianenrico, additional, Vianello, Andrea, additional, and Crisafulli, Ernesto, additional
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- 2021
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9. Economic impact of mepolizumab in uncontrolled severe eosinophilic asthma, in real life
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Bagnasco, Diego, primary, Povero, Massimiliano, additional, Pradelli, Lorenzo, additional, Brussino, Luisa, additional, Rolla, Giovanni, additional, Caminati, Marco, additional, Menzella, Francesco, additional, Heffler, Enrico, additional, Canonica, Giorgio Walter, additional, Paggiaro, Pierluigi, additional, Senna, Gianenrico, additional, Milanese, Manlio, additional, Lombardi, Carlo, additional, Bucca, Caterina, additional, Manfredi, Andrea, additional, Canevari, Rikki Frank, additional, Passalacqua, Giovanni, additional, Guarnieri, Gabriella, additional, Patella, Vincenzo, additional, Maria Pia, Foschino Barbaro, additional, Carpagnano, Elisiana, additional, Colle, Anna del, additional, Scioscia, Giulia, additional, Gerolamo, Pelaia, additional, Latorre, Manuela, additional, Puggioni, Francesca, additional, Racca, Francesca, additional, Favero, Elisabetta, additional, Iannacone, Sandra, additional, Savi, Eleonora, additional, Montagni, Marcello, additional, Camiciottoli, Gianna, additional, Allegrini, Chiara, additional, Spadaro, Giuseppe, additional, Detoraki, Caterina, additional, Galeone, Carla, additional, Ruggiero, Patrizia, additional, Yacoub, Monna Rita, additional, Berti, Alvise, additional, Colombo, Gisella, additional, Scichilone, Nicola, additional, Durante, Carmen, additional, Costantino, Maria Teresa, additional, Roncallo, Chiara, additional, Braschi, Mariachiara, additional, Blasi, Francesco, additional, D'Adda, Alice, additional, Ridolo, Erminia, additional, Triggiani, Massimo, additional, Parente, Roberta, additional, Maria, D'Amato, additional, Verrillo, Maria Vittoria, additional, Cristina, Zappa Maria, additional, Lilli, Marianna, additional, Crimi, Nunzio, additional, Bonavia, Marco, additional, Corsico, Angelo Guido, additional, Grosso, Amelia, additional, Del Giacco, Stefano, additional, Deidda, Margherita, additional, Ricciardi, Luisa, additional, Isola, Stefania, additional, Cicero, Francesca, additional, Amato, Giuliana, additional, Vita, Federica, additional, Spanevello, Antonio, additional, Pignatti, Patrizia, additional, Cherubino, Francesca, additional, Visca, Dina, additional, Aletti, Eleonora, additional, Massimo Ricciardolo, Fabio Luigi, additional, Anna Carriero, Vitina Maria, additional, Bertolini, Francesca, additional, Santus, Pierachille, additional, Barlassina, Roberta, additional, Airoldi, Andrea, additional, Guida, Giuseppe, additional, Eleonora, Nucera, additional, Aruanno, Arianna, additional, Rizzi, Angela, additional, Caruso, Cristiano, additional, Colantuono, Stefania, additional, Arcolaci, Alessandra, additional, Vianello, Andrea, additional, Bianchi, Fulvia Chieco, additional, Marchi, Maria Rita, additional, Centanni, Stefano, additional, Luraschi, Simone, additional, Ruggeri, Silvia, additional, Rinaldo, Rocco, additional, Parazzini, Elena, additional, Calabrese, Cecilia, additional, Flora, Martina, additional, Cosmi, Lorenzo, additional, Di Pietro, Linda, additional, Maggi, Enrico, additional, Pini, Laura, additional, Macchia, Luigi, additional, Di Bona, Danilo, additional, Richeldi, Luca, additional, Condoluci, Carola, additional, Fuso, Leonello, additional, Bonini, Matteo, additional, Farsi, Alessandro, additional, Carli, Giulia, additional, Montuschi, Paolo, additional, Santini, Giuseppe, additional, Conte, Maria Elisabetta, additional, Turchet, Elisa, additional, Barbetta, Carlo, additional, Mazza, Francesco, additional, D'Alo, Simona, additional, Pucci, Stefano, additional, Caiaffa, Maria Filomena, additional, Minenna, Elena, additional, D'Elia, Luciana, additional, Pasculli, Carlo, additional, Viviano, Vittorio, additional, Tarsia, Paolo, additional, Rolo, Joyce, additional, Di Proietto, Mariacarmela, additional, and Lo Cicero, Salvatore, additional
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- 2021
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10. Noninvasive methods for the detection of upper and lower airway inflammation in atopic children
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Profita, Mirella, La Grutta, Stefania, Carpagnano, Elisiana, Riccobono, Loredana, Di Giorgi, Rossana, Bonanno, Anna, Pace, Elisabetta, Bonsignore, Giovanni, Bousquet, Jean, Vignola, Antonio Maurizio, and Gjomarkaj, Mark
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- 2006
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11. Minimal clinically important difference for asthma endpoints: an expert consensus report
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Bonini, Matteo, primary, Di Paolo, Marcello, additional, Bagnasco, Diego, additional, Baiardini, Ilaria, additional, Braido, Fulvio, additional, Caminati, Marco, additional, Carpagnano, Elisiana, additional, Contoli, Marco, additional, Corsico, Angelo, additional, Del Giacco, Stefano, additional, Heffler, Enrico, additional, Lombardi, Carlo, additional, Menichini, Ilaria, additional, Milanese, Manlio, additional, Scichilone, Nicola, additional, Senna, Gianenrico, additional, and Canonica, Giorgio W., additional
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- 2020
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12. Association between exhaled nitric oxide and nasal polyposisin severe asthma
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Maniscalco, Mauro, primary, Calabrese, Cecilia, additional, D’Amato, Maria, additional, Molino, Antonio, additional, Aliani, Maria, additional, De Felice, Alberto, additional, Ricciardolo, Fabio, additional, and Carpagnano, Elisiana, additional
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- 2019
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13. Ultrasound lung surface: Basic considerations of ultrasound physics
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Sperandeo, Marco, primary, Quarato, Carla Maria Irene, additional, Frongillo, Elisabettamaria, additional, Tinti, Maria Giulia, additional, and Carpagnano, Elisiana, additional
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- 2019
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14. Coexistent Sarcoidosis and Tuberculosis: A Case Report
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Carbonelli, Cristiano, primary, Giuffreda, Ernesto, additional, Palmiotti, Antonio, additional, Loizzi, Domenico, additional, Lococo, Filippo, additional, Carpagnano, Elisiana, additional, Lacedonia, Donato, additional, Sollitto, Francesco, additional, and Foschino, Maria Pia, additional
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- 2017
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15. Economic impact of mepolizumab in uncontrolled severe eosinophilic asthma, in real life
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Diego Bagnasco, Massimiliano Povero, Lorenzo Pradelli, Luisa Brussino, Giovanni Rolla, Marco Caminati, Francesco Menzella, Enrico Heffler, Giorgio Walter Canonica, Pierluigi Paggiaro, Gianenrico Senna, Manlio Milanese, Carlo Lombardi, Caterina Bucca, Andrea Manfredi, Rikki Frank Canevari, Giovanni Passalacqua, Gabriella Guarnieri, Vincenzo Patella, Foschino Barbaro Maria Pia, Elisiana Carpagnano, Anna del Colle, Giulia Scioscia, Pelaia Gerolamo, Manuela Latorre, Francesca Puggioni, Francesca Racca, Elisabetta Favero, Sandra Iannacone, Eleonora Savi, Marcello Montagni, Gianna Camiciottoli, Chiara Allegrini, Giuseppe Spadaro, Caterina Detoraki, Carla Galeone, Patrizia Ruggiero, Monna Rita Yacoub, Alvise Berti, Gisella Colombo, Nicola Scichilone, Carmen Durante, Maria Teresa Costantino, Chiara Roncallo, Mariachiara Braschi, Francesco Blasi, Alice D'Adda, Erminia Ridolo, Massimo Triggiani, Roberta Parente, D'Amato Maria, Maria Vittoria Verrillo, Zappa Maria Cristina, Marianna Lilli, Nunzio Crimi, Marco Bonavia, Angelo Guido Corsico, Amelia Grosso, Stefano Del Giacco, Margherita Deidda, Luisa Ricciardi, Stefania Isola, Francesca Cicero, Giuliana Amato, Federica Vita, Antonio Spanevello, Patrizia Pignatti, Francesca Cherubino, Dina Visca, Eleonora Aletti, Fabio Luigi Massimo Ricciardolo, Vitina Maria Anna Carriero, Francesca Bertolini, Pierachille Santus, Roberta Barlassina, Andrea Airoldi, Giuseppe Guida, Nucera Eleonora, Arianna Aruanno, Angela Rizzi, Cristiano Caruso, Stefania Colantuono, Alessandra Arcolaci, Andrea Vianello, Fulvia Chieco Bianchi, Maria Rita Marchi, Stefano Centanni, Simone Luraschi, Silvia Ruggeri, Rocco Rinaldo, Elena Parazzini, Cecilia Calabrese, Martina Flora, Lorenzo Cosmi, Linda Di Pietro, Enrico Maggi, Laura Pini, Luigi Macchia, Danilo Di Bona, Luca Richeldi, Carola Condoluci, Leonello Fuso, Matteo Bonini, Alessandro Farsi, Giulia Carli, Paolo Montuschi, Giuseppe Santini, Maria Elisabetta Conte, Elisa Turchet, Carlo Barbetta, Francesco Mazza, Simona D'Alo, Stefano Pucci, Maria Filomena Caiaffa, Elena Minenna, Luciana D'Elia, Carlo Pasculli, Vittorio Viviano, Paolo Tarsia, Joyce Rolo, Mariacarmela Di Proietto, Salvatore Lo Cicero, Bagnasco, D., Povero, M., Pradelli, L., Brussino, L., Rolla, G., Caminati, M., Menzella, F., Heffler, E., Canonica, G. W., Paggiaro, P., Senna, G., Milanese, M., Lombardi, C., Bucca, C., Manfredi, A., Canevari, R. F., Passalacqua, G., Guarnieri, G., Patella, V., Maria Pia, F. B., Carpagnano, E., Colle, A. D., Scioscia, G., Gerolamo, P., Latorre, M., Puggioni, F., Racca, F., Favero, E., Iannacone, S., Savi, E., Montagni, M., Camiciottoli, G., Allegrini, C., Spadaro, G., Detoraki, C., Galeone, C., Ruggiero, P., Yacoub, M. R., Berti, A., Colombo, G., Scichilone, N., Durante, C., Costantino, M. T., Roncallo, C., Braschi, M., Blasi, F., D'Adda, A., Ridolo, E., Triggiani, M., Parente, R., Maria, D. A., Verrillo, M. V., Cristina, Z. M., Lilli, M., Crimi, N., Bonavia, M., Corsico, A. G., Grosso, A., Del Giacco, S., Deidda, M., Ricciardi, L., Isola, S., Cicero, F., Amato, G., Vita, F., Spanevello, A., Pignatti, P., Cherubino, F., Visca, D., Aletti, E., Massimo Ricciardolo, F. L., Anna Carriero, V. M., Bertolini, F., Santus, P., Barlassina, R., Airoldi, A., Guida, G., Eleonora, N., Aruanno, A., Rizzi, A., Caruso, C., Colantuono, S., Arcolaci, A., Vianello, A., Bianchi, F. C., Marchi, M. R., Centanni, S., Luraschi, S., Ruggeri, S., Rinaldo, R., Parazzini, E., Calabrese, C., Flora, M., Cosmi, L., Di Pietro, L., Maggi, E., Pini, L., Macchia, L., Di Bona, D., Richeldi, L., Condoluci, C., Fuso, L., Bonini, M., Farsi, A., Carli, G., Montuschi, P., Santini, G., Conte, M. E., Turchet, E., Barbetta, C., Mazza, F., D'Alo, S., Pucci, S., Caiaffa, M. F., Minenna, E., D'Elia, L., Pasculli, C., Viviano, V., Tarsia, P., Rolo, J., Di Proietto, M., Lo Cicero, S., Bagnasco, Diego, Povero, Massimiliano, Pradelli, Lorenzo, Brussino, Luisa, Rolla, Giovanni, Caminati, Marco, Menzella, Francesco, Heffler, Enrico, Canonica, Giorgio Walter, Paggiaro, Pierluigi, Senna, Gianenrico, Milanese, Manlio, Lombardi, Carlo, Bucca, Caterina, Manfredi, Andrea, Canevari, Rikki Frank, Passalacqua, Giovanni, Guarnieri, Gabriella, Patella, Vincenzo, Foschino Barbaro, Maria Pia, Carpagnano, Elisiana, D' Amato, Maria, Verrillo, Mariavittoria, Zappa, Maria Cristina, Lo Cicero, Salvatore, Di Proietto, Maria Carmela, Walter Canonica, Giorgio, Frank Canevari, Rikki, Spadaro, Giuseppe, Bagnasco D., Povero M., Pradelli L., Brussino L., Rolla G., Caminati M., Menzella F., Heffler E., Canonica G.W., Paggiaro P., Senna G., Milanese M., Lombardi C., Bucca C., Manfredi A., Canevari R.F., Passalacqua G., Guarnieri G., Patella V., Maria Pia F.B., Carpagnano E., Colle A.D., Scioscia G., Gerolamo P., Latorre M., Puggioni F., Racca F., Favero E., Iannacone S., Savi E., Montagni M., Camiciottoli G., Allegrini C., Spadaro G., Detoraki C., Galeone C., Ruggiero P., Yacoub M.R., Berti A., Colombo G., Scichilone N., Durante C., Costantino M.T., Roncallo C., Braschi M., Blasi F., D'Adda A., Ridolo E., Triggiani M., Parente R., Maria D.A., Verrillo M.V., Cristina Z.M., Lilli M., Crimi N., Bonavia M., Corsico A.G., Grosso A., Del Giacco S., Deidda M., Ricciardi L., Isola S., Cicero F., Amato G., Vita F., Spanevello A., Pignatti P., Cherubino F., Visca D., Aletti E., Massimo Ricciardolo F.L., Anna Carriero V.M., Bertolini F., Santus P., Barlassina R., Airoldi A., Guida G., Eleonora N., Aruanno A., Rizzi A., Caruso C., Colantuono S., Arcolaci A., Vianello A., Bianchi F.C., Marchi M.R., Centanni S., Luraschi S., Ruggeri S., Rinaldo R., Parazzini E., Calabrese C., Flora M., Cosmi L., Di Pietro L., Maggi E., Pini L., Macchia L., Di Bona D., Richeldi L., Condoluci C., Fuso L., Bonini M., Farsi A., Carli G., Montuschi P., Santini G., Conte M.E., Turchet E., Barbetta C., Mazza F., D'Alo S., Pucci S., Caiaffa M.F., Minenna E., D'Elia L., Pasculli C., Viviano V., Tarsia P., Rolo J., Di Proietto M., and Lo Cicero S.
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OR, Odds Ratio ,Pediatrics ,Severe asthma ,Exacerbation ,Anti IL-5 ,Comorbidities ,Mepolizumab ,OCS ,Pharmacoeconomics ,gastroesophageal reflux disease ,Settore MED/10 - MALATTIE DELL'APPARATO RESPIRATORIO ,ICS, inhaled corticosteroid ,Rate ratio ,OCS, Oral Corticosteroids ,law.invention ,LAMA, long acting muscarinic antagonist ,0302 clinical medicine ,Randomized controlled trial ,fractional nitric oxide ,Interquartile range ,law ,long acting beta 2 agonist ,Odds Ratio ,Immunology and Allergy ,RR, Rate Ratio ,030223 otorhinolaryngology ,Pharmacoeconomic ,LOS, Length of stay ,LOS ,IQR ,LAMA ,MEP, Mepolizumab ,OR ,CI ,SD, Standard Deviation ,MEP ,ACT, Asthma Control Test ,Comorbiditie ,CI, Confidence Intervals ,medicine.drug ,lcsh:Immunologic diseases. Allergy ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,interquartile range ,long acting muscarinic antagonist ,Immunology ,LABA ,LABA, long acting beta 2 agonist ,Comorbidities, Mepolizumab, OCS, Pharmacoeconomics, Severe asthma, Anti IL-5 ,RR ,Article ,Rate Ratio ,chronic obstructive pulmonary disease ,03 medical and health sciences ,OCS, Oral Corticosteroid ,Asthma Control Test ,Confidence Intervals ,FeNO, fractional nitric oxide ,RCTs, Randomized Controlled Trial ,medicine ,COPD ,GERD, gastroesophageal reflux disease ,FeNO ,IQR, interquartile range ,SD ,Asthma ,RCTs ,Oral Corticosteroids ,business.industry ,GERD ,medicine.disease ,ICS, inhaled corticosteroids ,ACT ,Comorbidity ,Randomized Controlled Trials ,CI, Confidence Interval ,RCTs, Randomized Controlled Trials ,COPD, chronic obstructive pulmonary disease ,030228 respiratory system ,ICS ,Standard Deviation ,Length of stay ,inhaled corticosteroids ,lcsh:RC581-607 ,business - Abstract
Background and aims Severe asthma is burdened by frequent exacerbations and use of oral corticosteroids (OCS) which worsen patients’ health and increase healthcare spending. Aim of this study was to assess the clinical and economic effect of adding mepolizumab (MEP) for the treatment of these patients. Methods Patients >18 years old, referred to 8 asthma clinics, starting MEP between May 2017 and December 2018, were enrolled and followed-up for 12 months. Information in the 12 months before mepolizumab were collected retrospectively. The evaluation parameters included: OCS use, number of exacerbations/hospitalizations, concomitant therapies, comorbidity, and annual number of working days lost due to the disease. The primary objective was to compare the annual total cost per patient pre- and post-MEP. Secondary outcomes included rates of exacerbations and number of OCS-dependent patients. Results 106 patients were enrolled in the study: 46 male, median age 58 years. Mean annual cost pre- and post-MEP (cost of biologic excluded) was €3996 and €1,527, respectively. Total savings due to MEP resulted in €2469 (95%CI 1945–2993), 62% due to exacerbations reduction and 33% due to productivity increase. Such savings could fund about 22% of the total cost of MEP for one year. The introduction of MEP induced a clinical benefit by reducing both OCS-dependent patients (OR = 0.12, 95%CI 0.06–0.23) and exacerbation rate (RR = 0.19, 95%CI 0.15–0.24). Conclusions Patients with severe eosinophilic asthma experienced a clinical benefit in asthma control adding MEP to standard therapy. Biologic therapy can be, partially, funded by the savings produced by patients’ improvement.
- Published
- 2021
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