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17 results on '"Carotenuto, Immacolata"'

6. A window into the mind-brain-body interplay: Development of diagnostic, prognostic biomarkers, and rehabilitation strategies in functional motor disorders.

Author

Gandolfi, Marialuisa, Sandri, Angela, Mariotto, Sara, Tamburin, Stefano, Paolicelli, Anna, Fiorio, Mirta, Pedrotti, Giulia, Barone, Paolo, Pellecchia, Maria Teresa, Erro, Roberto, Cuoco, Sofia, Carotenuto, Immacolata, Vinciguerra, Claudia, Botto, Annibale, Zenere, Lucia, Canu, Elisa, Sibilla, Elisa, Filippi, Massimo, Sarasso, Elisabetta, and Agosta, Federica

Subjects
MOVEMENT disorders, PROGNOSIS, NEUROLOGICAL disorders, DELAYED diagnosis, PSYCHOLOGICAL factors, INTEROCEPTION
Abstract

Background and aims: Functional motor disorders (FMD) present a prevalent, yet misunderstood spectrum of neurological conditions characterized by abnormal movements (i.e., functional limb weakness, tremor, dystonia, gait impairments), leading to substantial disability and diminished quality of life. Despite their high prevalence, FMD often face delayed diagnosis and inadequate treatment, resulting in significant social and economic burdens. The old concept of psychological factors as the primary cause (conversion disorder) has been abandoned due to the need for more evidence about their causal role. According to a predictive coding account, the emerging idea is that symptoms and disability may depend on dysfunctions of a specific neural system integrating interoception, exteroception, and motor control. Consequently, symptoms are construed as perceptions of the body's state. Besides the main pathophysiological features (abnormal attentional focus, beliefs/expectations, and sense of agency), the lived experience of symptoms and their resulting disability may depend on an altered integration at the neural level of interoception, exteroception, and motor control. Methods and materials: Our proposal aims to elucidate the pathophysiological mechanisms of FMD through a three-stage research approach. Initially, a large cohort study will collect behavioral, neurophysiological, and MRI biomarkers from patients with FMD and healthy controls, employing eXplainable Artificial Intelligence (XAI) to develop a diagnostic algorithm. Subsequently, validation will occur using patients with organic motor disorders. Finally, the algorithm's prognostic value will be explored post-rehabilitation in one subgroup of patients with FMD. Results: Data collection for the present study started in May 2023, and by May 2025, data collection will conclude. Discussion: Our approach seeks to enhance early diagnosis and prognostication, improve FMD management, and reduce associated disability and socio-economic costs by identifying disease-specific biomarkers. Trial registration: This trial was registered in clinicaltrials.gov (NCT06328790). [ABSTRACT FROM AUTHOR]

Published
2024
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9. Validation of the Italian version of the PSP Quality of Life questionnaire

Author

Picillo, Marina, Cuoco, Sofia, Amboni, Marianna, Bonifacio, Francesco Paolo, Bruschi, Fabio, Carotenuto, Immacolata, De Micco, Rosa, De Rosa, Anna, Del Prete, Eleonora, Di Biasio, Francesca, Elifani, Francesca, Erro, Roberto, Fabbri, Margherita, Falla, Marika, Franco, Giulia, Frosini, Daniela, Galantucci, Sebastiano, Lazzeri, Giulia, Magistrelli, Luca, Malaguti, Maria Chiara, Milner, Anna Vera, Minafra, Brigida, Olivola, Enrica, Pilotto, Andrea, Rascunà, Cristina, Rizzetti, Maria Cristina, Schirinzi, Tommaso, Borroni, Barbara, Ceravolo, Roberto, Di Fonzo, Alessio, Marchese, Roberta, Mercuri, Nicola B., Modugno, Nicola, Nicoletti, Alessandra, Padovani, Alessandro, Santangelo, Gabriella, Stefani, Alessandro, Tessitore, Alessandro, Volontè, Maria Antonietta, Zangaglia, Roberta, Zappia, Mario, Zibetti, Maurizio, and Barone, Paolo

Published
2019
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10. Fist-Palm Test

Author

Cuoco, Sofia, primary, Erro, Roberto, additional, Carotenuto, Immacolata, additional, Picillo, Marina, additional, Pellecchia, Maria Teresa, additional, and Barone, Paolo, additional

Published
2022
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11. Resilience Scale-14; Italian Version

Author

Cuoco, Sofa, primary, Carotenuto, Immacolata, additional, Cappiello, Arianna, additional, Bisogno, Rossella, additional, Picillo, Marina, additional, Pellecchia, Maria Teresa, additional, Barone, Paolo, additional, and Erro, Roberto, additional

Published
2022
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13. Relationship Between Orthostatic Hypotension and Cognitive Functions in Multiple System Atrophy: A Longitudinal Study

Author

Cuoco, Sofia, primary, Carotenuto, Immacolata, additional, Cappiello, Arianna, additional, Scannapieco, Sara, additional, Russillo, Maria Claudia, additional, Andreozzi, Valentina, additional, Forino, Lorenzo, additional, Amboni, Marianna, additional, Picillo, Marina, additional, Erro, Roberto, additional, Barone, Paolo, additional, and Pellecchia, Maria Teresa, additional

Published
2021
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14. Gait Analysis in Progressive Supranuclear Palsy Phenotypes

Author

Picillo, Marina, primary, Ricciardi, Carlo, additional, Tepedino, Maria Francesca, additional, Abate, Filomena, additional, Cuoco, Sofia, additional, Carotenuto, Immacolata, additional, Erro, Roberto, additional, Ricciardelli, Gianluca, additional, Russo, Michela, additional, Cesarelli, Mario, additional, Barone, Paolo, additional, and Amboni, Marianna, additional

Published
2021
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16. Progressive Supranuclear Palsy Quality of Life Scale--Italian Version

Author

Picillo, Marina, primary, Cuoco, Sofia, additional, Amboni, Marianna, additional, Bonifacio, Francesco Paolo, additional, Bruschi, Fabio, additional, Carotenuto, Immacolata, additional, De Micco, Rosa, additional, De Rosa, Anna, additional, Del Prete, Eleonora, additional, Di Biasio, Francesca, additional, Elifani, Francesca, additional, Erro, Roberto, additional, Fabbri, Margherita, additional, Falla, Marika, additional, Franco, Giulia, additional, Frosini, Daniela, additional, Galantucci, Sebastiano, additional, Lazzeri, Giulia, additional, Magistrelli, Luca, additional, Malaguti, Maria Chiara, additional, Milner, Anna Vera, additional, Minafra, Brigida, additional, Olivola, Enrica, additional, Pilotto, Andrea, additional, Rascunà, Cristina, additional, Rizzetti, Maria Cristina, additional, Schirinzi, Tommaso, additional, Borroni, Barbara, additional, Ceravolo, Roberto, additional, Di Fonzo, Alessio, additional, Marchese, Roberta, additional, Mercuri, Nicola B., additional, Modugno, Nicola, additional, Nicoletti, Alessandra, additional, Padovani, Alessandro, additional, Santangelo, Gabriella, additional, Stefani, Alessandro, additional, Tessitore, Alessandro, additional, Volontè, Maria Antonietta, additional, Zangaglia, Roberta, additional, Zappia, Mario, additional, Zibetti, Maurizio, additional, and Barone, Paolo, additional

Published
2019
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17. Validation of the Italian version of the PSP Quality of Life questionnaire

Author

Francesca Di Biasio, Alessandra Nicoletti, Alessandro Padovani, Anna Vera Milner, Mario Zappia, Nicola Modugno, Brigida Minafra, Luca Magistrelli, Marina Picillo, Sebastiano Galantucci, Enrica Olivola, Paolo Barone, Fabio Bruschi, Roberta Marchese, Rosa De Micco, Maurizio Zibetti, Sofia Cuoco, Nicola Biagio Mercuri, Roberta Zangaglia, Maria Cristina Rizzetti, Alessio Di Fonzo, Immacolata Carotenuto, Francesco Paolo Bonifacio, Maria Chiara Malaguti, Giulia Lazzeri, Daniela Frosini, Andrea Pilotto, Marianna Amboni, Giulia Franco, Eleonora Del Prete, Alessandro Tessitore, Tommaso Schirinzi, Margherita Fabbri, Alessandro Stefani, Francesca Elifani, Barbara Borroni, Anna De Rosa, Maria Antonietta Volontè, Roberto Ceravolo, Marika Falla, Cristina Rascunà, Roberto Erro, Gabriella Santangelo, Picillo, Marina, Cuoco, Sofia, Amboni, Marianna, Bonifacio, Francesco Paolo, Bruschi, Fabio, Carotenuto, Immacolata, De Micco, Rosa, De Rosa, Anna, Del Prete, Eleonora, Di Biasio, Francesca, Elifani, Francesca, Erro, Roberto, Fabbri, Margherita, Falla, Marika, Franco, Giulia, Frosini, Daniela, Galantucci, Sebastiano, Lazzeri, Giulia, Magistrelli, Luca, Malaguti, Maria Chiara, Milner, Anna Vera, Minafra, Brigida, Olivola, Enrica, Pilotto, Andrea, Rascunà, Cristina, Rizzetti, Maria Cristina, Schirinzi, Tommaso, Borroni, Barbara, Ceravolo, Roberto, Di Fonzo, Alessio, Marchese, Roberta, Mercuri, Nicola B, Modugno, Nicola, Nicoletti, Alessandra, Padovani, Alessandro, Santangelo, Gabriella, Stefani, Alessandro, Tessitore, Alessandro, Volontè, Maria Antonietta, Zangaglia, Roberta, Zappia, Mario, Zibetti, Maurizio, Barone, Paolo, Picillo, M., Cuoco, S., Amboni, M., Bonifacio, F. P., Bruschi, F., Carotenuto, I., De Micco, R., De Rosa, A., Del Prete, E., Di Biasio, F., Elifani, F., Erro, R., Fabbri, M., Falla, M., Franco, G., Frosini, D., Galantucci, S., Lazzeri, G., Magistrelli, L., Malaguti, M. C., Milner, A. V., Minafra, B., Olivola, E., Pilotto, A., Rascuna, C., Rizzetti, M. C., Schirinzi, T., Borroni, B., Ceravolo, R., Di Fonzo, A., Marchese, R., Mercuri, N. B., Modugno, N., Nicoletti, A., Padovani, A., Santangelo, G., Stefani, A., Tessitore, A., Volonte, M. A., Zangaglia, R., Zappia, M., Zibetti, M., and Barone, P.

Subjects
Male, medicine.medical_specialty, Neurology, Movement disorders, Psychometrics, Psychological intervention, Dermatology, Disease, Parkinsonism, Settore MED/26, 03 medical and health sciences, 0302 clinical medicine, Clinical trials, Progressive supranuclear palsy, Quality of life, Cronbach's alpha, Progressive, 80 and over, Medicine, Supranuclear Palsy, Humans, 030212 general & internal medicine, Aged, Aged, 80 and over, business.industry, Reproducibility of Results, General Medicine, medicine.disease, Female, Italy, Self Report, Supranuclear Palsy, Progressive, Quality of Life, humanities, eye diseases, Clinical trial, Psychiatry and Mental health, Convergent validity, Physical therapy, Neurology (clinical), medicine.symptom, business, 030217 neurology & neurosurgery
Abstract

Background: Progressive supranuclear palsy (PSP) is a rare rapidly progressive, neurodegenerative disease characterized by falls and ocular movement disturbances. The use of health-related quality of life (HR-QoL) measures allows assessing changes in health status induced by therapeutic interventions or disease progress in neurodegenerative diseases. The PSP-QoL is a 45-item, self-administered questionnaire designed to evaluate HR-QoL in PSP. Methods and Results: Here, the PSP-QoL was translated into Italian and validated in 190 PSP (96 women and 94 men; mean age ± standard deviation, 72 ± 6.5; mean disease duration, 4.2 ± 2.3) patients diagnosed according to the Movement Disorder Society criteria and recruited in 16 third level movement disorders centers participating in the Neurecanet project. The mean PSP-QoL total score was 77.8 ± 37 (physical subscore, 46.5 ± 18.7; mental subscore, 33.6 ± 19.2). The internal consistency was high (Cronbach’s alpha = 0.954); corrected item-total correlation was > 0.40 for the majority of items. The significant and moderate correlation of the PSP-QoL with other HR-QoL measures as well as with motor and disability assessments indicated adequate convergent validity of the scale. Gender and geographic location presented a significant impact on the PSP-QoL in our sample with women and patients from the South of Italy scoring higher than their counterparts. Conclusion: In conclusion, the Italian version of the PSP-QoL is an easy, reliable and valid tool for assessment of HR-QoL in PSP.

Published
2019

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