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23. A Clinical Outcome-Based Prospective Study on Venous Thromboembolism After Cancer Surgery The @RISTOS Project

Author

Agnelli, Giancarlo, Bolis, Giorgio, Capussotti, Lorenzo, Scarpa, Roberto Mario, Tonelli, Francesco, Bonizzoni, Erminio, Moia, Marco, Parazzini, Fabio, Rossi, Romina, Sonaglia, Francesco, Valarani, Bettina, Bianchini, Carlo, Gussoni, Gualberto, Tonelli, F., Martinelli, I., Andreoni, B., Biffi, R., Cenciarelli, S., Calgaro, M., Polastri, R., Zorzi, D., Tubaro, A., Perna, R., Vicentini, C., Montemurro, S., Caliandro, C., Ruggeri, E., Gennari, L., Brocchi, A., Quagliuolo, V., Ragni, F., Conti, G., Cretarola, E., Pagliarulo, A., D'Achille, G., Bartoli, A., Bussotti, C., Ricci, E., Servoli, A., Carrieri, G., Corvasce, T., Disabato, G., Moretti, R., Bencini, L., Cantafio, S., Scatizzi, M., Scambia, G., Foti, E., Frigerio, L., Carlini, L., Gallo, A., Mirone, V., Mangiapia, F., Palmieri, A., Mazzaferro, V., Ravagnani, F., Romito, R., Ferrari, A., Mangili, G., Carnelli, P., Vigano', RENATA MARIA, Dionigi, R., Castelli, P., Caronno, R., Piffaretti, G., Uccella, L., Parisi, Veronica, Ruffolo, F., Verrusio, C., Tateo, S., Mereu, L., Salamano, S., Valanzano, R., Lise, M., Nitti, D., Belluco, C., Forlin, M., Massarut, R., Usai, E., De Lisa, A., Cirillo, P., Mosella, G., Quarto, G., Cappiello, A., Mosella, F., Pastore, M., Mangioni, C., Pellegrino, A., Villa, A., Daddi, G., Cagini, L., Calzolari, F., Nigro, R., Confuorto, G., Pecorelli, S., Odicino, F., Sacconi, T., Scollo, P., Scibilia, G., DEL GAUDIO, Andrea, Accorsi, D., Fiaccavento, G., Plaino, F., Agnelli, G, Bolis, G, Capussotti, L, Scarpa, Rm, Tonelli, F, Bonizzoni, E, Moia, M, Parazzini, F, Rossi, R, Sonaglia, F, Valarani, B, Bianchini, C, Gussoni, G, ]Department of General, @ristos study group: [. ., Geriatric, Oncological, Surgery, Advanced, Technologie, 'Federico II' University, and Napoli

Subjects
Male, medicine.medical_specialty, Deep vein, Population, Embolism, Venography, Chemoprevention, Fibrinolytic Agents, Neoplasms, Medicine, Humans, cardiovascular diseases, Prospective Studies, education, Prospective cohort study, Aged, Venous Thrombosis, education.field_of_study, medicine.diagnostic_test, business.industry, Mortality rate, Incidence, cancer surgery, Venous Thromboembolism, Original Articles, Middle Aged, equipment and supplies, medicine.disease, Surgery, Pulmonary embolism, Clinical trial, Venous thrombosis, medicine.anatomical_structure, Treatment Outcome, Italy, Surgical Procedures, Operative, Female, business
Abstract

Citato 156 volte in letteratura internazionale (Fonte: www.scopus.com). Citato 143 volte in letteratura internazionale (Fonte: apps.webofknowledge.com). Citato 212 volte in letteratura internazionale (Fonte: http://scholar.google.com/) Studio multicentrico. I membri dei vari centri sono indicati singolarmente in quota al proprio dipartimento universitario/centro di appartenenza nel paragrafo "Acknowledgment". Abstract Summary Background Data: The epidemiology of venous thromboembolism (VTE) after cancer surgery is based on clinical trials on VTE prophylaxis that used venography to screen deep vein thrombosis (DVT). However, the clinical relevance of asymptomatic venography-detected DVT is unclear, and the population of these clinical trials is not necessarily representative of the overall cancer surgery population. Objective: The aim of this study was to evaluate the incidence of clinically overt VTE in a wide spectrum of consecutive patients undergoing surgery for cancer and to identify risk factors for VTE. Methods: @RISTOS was a prospective observational study in patients undergoing general, urologic, or gynecologic surgery. Patients were assessed for clinically overt VTE occurring up to 30 ± 5 days after surgery or more if the hospital stay was longer than 35 days. All outcome events were evaluated by an independent Adjudication Committee. Results: A total of 2373 patients were included in the study: 1238 (52%) undergoing general, 685 (29%) urologic, and 450 (19%) gynecologic surgery. In-hospital prophylaxis was given in 81.6% and postdischarge prophylaxis in 30.7% of the patients. Fifty patients (2.1%) were adjudicated as affected by clinically overt VTE (DVT, 0.42%; nonfatal pulmonary embolism, 0.88%; death 0.80%). The incidence of VTE was 2.83% in general surgery, 2.0% in gynecologic surgery, and 0.87% in urologic surgery. Forty percent of the events occurred later than 21 days from surgery. The overall death rate was 1.72%; in 46.3% of the cases, death was caused by VTE. In a multivariable analysis, 5 risk factors were identified: age above 60 years (2.63, 95% confidence interval, 1.21-5.71), previous VTE (5.98, 2.13-16.80), advanced cancer (2.68, 1.37-5.24), anesthesia lasting more than 2 hours (4.50, 1.06-19.04), and bed rest longer than 3 days (4.37, 2.45-7.78). Conclusions: VTE remains a common complication of cancer surgery, with a remarkable proportion of events occurring late after surgery. In patients undergoing cancer surgery, VTE is the most common cause of death at 30 days after surgery. Copyright © 2005 by Lippincott Williams & Wilkins.

Published
2006

25. Gestione e trattamento endovascolare degli aneurismi dell'aorta addominale sintomatici

Author

Laganà, D, Carrafiello, Gianpaolo, Mangini, Monica, Giorgianni, Andrea, Caronno, R., Castelli, Patrizio, Dionigi, Gianlorenzo, Cuffari, S., and Fugazzola, Carlo

Subjects
Male, Iliac Artery, Abdominal aortic aneurysm rupture, Aortic Aneurysm, X-Ray Computed, Blood Vessel Prosthesis, Blood Vessel Prosthesis Implantation, Treatment Outcome, Nuclear Medicine and Imaging, 80 and over, Feasibility Studies, Humans, Endovascular treatment, Stent-grafts, Aged, Aorta, Abdominal, Emergency Treatment, Female, Stents, Tomography, Radiology, Aged, 80 and over, Aorta, Abdominal, Aortic Aneurysm, Abdominal, Tomography, X-Ray Computed, Radiology, Nuclear Medicine and Imaging
Published
2006

46. Trattamento ibrido per aneurismi toracici

Author

Castelli, Patrizio, Caronno, R, Piffaretti, G, Carnini, M, Tozzi, Matteo, Guzzardi, G, Lomazzi, C, Lagana', D, Carrafiello, Gianpaolo, and Cuffari, S.

Published
2005

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