Search

Your search keyword '"Caron B"' showing total 2,702 results
Start Over Author "Caron B"

Refine your results

more »

more »

more »

more »

more »
2,702 results on '"Caron B"'

1. A Platelet Reactivity ExpreSsion Score derived from patients with peripheral artery disease predicts cardiovascular risk

Author

Jeffrey S. Berger, Macintosh G. Cornwell, Yuhe Xia, Matthew A. Muller, Nathaniel R. Smilowitz, Jonathan D. Newman, Florencia Schlamp, Caron B. Rockman, Kelly V. Ruggles, Deepak Voora, Judith S. Hochman, and Tessa J. Barrett

Subjects
Science
Abstract

Abstract Platelets are key mediators of atherothrombosis, yet, limited tools exist to identify individuals with a hyperreactive platelet phenotype. In this study, we investigate the association of platelet hyperreactivity and cardiovascular events, and introduce a tool, the Platelet Reactivity ExpreSsion Score (PRESS), which integrates platelet aggregation responses and RNA sequencing. Among patients with peripheral artery disease (PAD), those with a hyperreactive platelet response (>60% aggregation) to 0.4 µM epinephrine had a higher incidence of the 30 day primary cardiovascular endpoint (37.2% vs. 15.3% in those without hyperreactivity, adjusted HR 2.76, 95% CI 1.5–5.1, p = 0.002). PRESS performs well in identifying a hyperreactive phenotype in patients with PAD (AUC [cross-validation] 0.81, 95% CI 0.68 –0.94, n = 84) and in an independent cohort of healthy participants (AUC [validation] 0.77, 95% CI 0.75 –0.79, n = 35). Following multivariable adjustment, PAD individuals with a PRESS score above the median are at higher risk for a future cardiovascular event (adjusted HR 1.90, CI 1.07–3.36; p = 0.027, n = 129, NCT02106429). This study derives and validates the ability of PRESS to discriminate platelet hyperreactivity and identify those at increased cardiovascular risk. Future studies in a larger independent cohort are warranted for further validation. The development of a platelet reactivity expression score opens the possibility for a personalized approach to antithrombotic therapy for cardiovascular risk reduction.

Published
2024
Full Text
View/download PDF

2. Risk factors, transcriptomics, and outcomes of myocardial injury following lower extremity revascularization

Author

Nathaniel R. Smilowitz, MacIntosh Cornwell, Erik J. Offerman, Caron B. Rockman, Svati H. Shah, Jonathan D. Newman, Kelly Ruggles, Deepak Voora, and Jeffrey S. Berger

Subjects
Medicine, Science
Abstract

Abstract Myocardial injury after non-cardiac surgery (MINS) is common. We investigated the incidence and outcomes of MINS, and mechanistic underpinnings using pre-operative whole blood gene expression profiling in a prospective cohort study of individuals undergoing lower extremity revascularization (LER) for peripheral artery disease (PAD). Major adverse cardiovascular and limb events (MACLE) were defined as a composite of death, myocardial infarction, stroke, major lower extremity amputation or reoperation. Among 226 participants undergoing LER, MINS occurred in 53 (23.5%). Patients with MINS had a greater incidence of major adverse cardiovascular events (49.1% vs. 22.0%, adjusted HR 1.87, 95% CI 1.07–3.26) and MACLE (67.9% vs. 44.5%; adjusted HR 1.66, 95% CI 1.08–2.55) at median 20-month follow-up. Pre-operative whole blood transcriptome profiling of a nested matched MINS case–control cohort (n = 41) identified upregulation of pathways related to platelet alpha granules and coagulation in patients who subsequently developed MINS. Thrombospondin 1 (THBS1) mRNA expression was 60% higher at baseline in patients who later developed MINS, and was independently associated with long-term cardiovascular events in the Duke Catheterization Genetics biorepository cohort. In conclusion, pre-operative THBS1 mRNA expression is higher in patients who subsequently develop MINS and is associated with incident cardiovascular events. Pathways related to platelet activity and coagulation associated with MINS provide novel insights into mechanisms of myocardial injury.

Published
2022
Full Text
View/download PDF

3. Arterial thromboembolism associated with COVID-19 and elevated D-dimer levels

Author

Karan Garg, MD, Michael E. Barfield, MD, Michael L. Pezold, MD, Mikel Sadek, MD, Neal S. Cayne, MD, Joanelle Lugo, MD, Thomas S. Maldonado, MD, Todd L. Berland, MD, Caron B. Rockman, MD, and Glenn R. Jacobowitz, MD

Subjects
COVID-19, Arterial thromboembolism, D-dimer, Surgery, RD1-811, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

The novel coronavirus 2019 (SARS-CoV-2) was first identified in January 2020 and has since evolved into a pandemic affecting >200 countries. The severity of presentation is variable and carries a mortality between 1% and 3%. We continue to learn about the virus and the resulting acute respiratory illness and hypercoagulability; however, much remains unknown. In our early experience in a high-volume center, we report a series of four cases of acute peripheral artery ischemia in patients with COVID-19 in the setting of elevated D-dimer levels.

Published
2020
Full Text
View/download PDF

5. Proatherogenic Oxidized Low-Density Lipoprotein/β2-Glycoprotein I Complexes in Arterial and Venous Disease

Author

Jeffrey S. Berger, Caron B. Rockman, Kirk E. Guyer, and Luis R. Lopez

Subjects
Immunologic diseases. Allergy, RC581-607
Abstract

OxLDL/β2GPI complexes have been implicated in the initiation and progression of atherosclerosis and associated with disease severity and adverse outcomes. We investigate the significance of anti-oxLDL/β2GPI antibodies and oxLDL/β2GPI complexes in patients with arterial and idiopathic venous disease. A cohort of 61 arterial disease patients, 32 idiopathic venous disease patients, and 53 healthy controls was studied. Because statins influence oxLDL/β2GPI, these complexes were analyzed on subjects not taking statins. Arterial and venous groups expressed higher levels of IgG anti-oxLDL/β2GPI antibodies than controls without any other significant clinical association. OxLDL/β2GPI complexes were significantly elevated in arterial (0.69 U/mL, P=0.004) and venous disease (0.54 U/mL, P=0.025) than controls (0.39 U/mL). Among arterial diseases, oxLDL/β2GPI was 0.85 U/mL for carotid artery disease, 0.72 U/mL for peripheral artery disease, and 0.52 U/mL for abdominal aortic aneurysm. There was a significant association with male gender, age, hypertension, and history of thrombosis. Subjects with oxLDL/β2GPI above the median (0.25 U/mL) were more likely to have arterial (OR 4.5, P=0.004) or venous disease (OR 4.1, P=0.008). Multivariate regression indicated that males (P=0.021), high cholesterol (P=0.011), and carotid disease (P=0.023) were significant predictors of oxLDL/β2GPI. The coexistence of oxLDL/β2GPI in arterial and venous disease may suggest a common oxidative mechanism that independently predicts carotid artery disease.

Published
2014
Full Text
View/download PDF

13. Taking on the Challenge: Building a Strong Foundation for Early Learning. Early Learning Challenge Summary Report

Author

Early Learning Challenge Technical Assistance (ELC TA), Department of Education (ED), Administration for Children and Families (DHHS), Applied Engineering Management Corporation (AEM), Caron, B., Kendall, R., Wilson, G., and Hash. M.

Abstract

The Early Learning Challenge (ELC) program awarded more than $1 billion in four-year grants to 20 States to implement comprehensive and cohesive high-quality early learning systems that support young children with high needs and their families. A key lever in making these improvements was the enhancement of States' Quality Rating and Improvement Systems (QRIS). A QRIS is designed to measure, rate, and dissemination information about the quality of the early learning and development programs that participate in the QRIS. Through ELC, States worked across agencies to improve, or in some cases, reinvent their QRIS. This report summarizes the progress ELC States made since the program began in 2012. It includes selected examples of key initiatives States undertook to create a comprehensive system of high-quality programs for young children and their families. Specifically, it looks at States' efforts to refine their QRIS; examine progress elements (including early learning standards, screenings, and assessment systems); engage and support families; support the early learning workforce; enhance early childhood data systems; and foster community connections. The content was drawn from States' ELC Annual and Final Performance Reports. As a result of the efforts States have undertaken, it can now be said that more children with high needs are enrolled in high-quality programs and more programs participate in the States' QRIS. States made progress in developing and strengthening their comprehensive early learning and development systems. States used the ELC program to make advancements and drive positive changes in their early learning and development systems, often in the face of significant challenges. Other States are benefiting from these experiences and lessons as they work on improving their own systems.

Published
2017

27. SuperCam calibration targets on board the perseverance rover: Fabrication and quantitative characterization

Author

Cousin, A., Sautter, V., Fabre, C., Dromart, G., Montagnac, G., Drouet, C., Meslin, P.Y., Gasnault, O., Beyssac, O., Bernard, S., Cloutis, E., Forni, O., Beck, P., Fouchet, T., Johnson, J.R., Lasue, J., Ollila, A.M., De Parseval, P., Gouy, S., Caron, B., Madariaga, J.M., Arana, G., Madsen, M. Bo, Laserna, J., Moros, J., Manrique, J.A., Lopez-Reyes, G., Rull, F., Maurice, S., and Wiens, R.C.

Published
2022
Full Text
View/download PDF

33. Moderate to Severe Preoperative Anemia is Associated With Increased Postoperative Myocardial Infarction and Mortality in Patients Undergoing Transcarotid Artery Revascularization

Author

Chang, Heepeel, primary, Veith, Frank, additional, Maldonado, Thomas S., additional, Laskowski, Igor, additional, Rockman, Caron B., additional, Zeeshan, Muhammad, additional, Jacobowitz, Glenn R., additional, Ebanks, Mikaiel, additional, Gandhi, Chirag, additional, Chong, Ji, additional, Mateo, Romeo, additional, Babu, Sateesh, additional, and Garg, Karan, additional

Published
2024
Full Text
View/download PDF

44. Sedimentary Records in the Lesser Antilles Fore‐Arc Basins Provide Evidence of Large Late Quaternary Megathrust Earthquakes

Author

Seibert, C., Feuillet, N., Ratzov, Gueorgui, Beck, C., Morena, Pierre, Johannes, L., Ducassou, E., Cattaneo, Antonio, Goldfinger, C., Moreno, E., Bieber, A., Bénâtre, G., Caron, B., Caron, M., Casse, M., Cavailhes, T., Del Manzo, G., Deschamps, C. E., Desiage, P. A., Duboc, Q., Fauquembergue, K., Ferrant, Anthony, Guyard, H., Jacques, E., Laurencin, M., Leclerc, F., Patton, J., Saurel, J. M., St‐onge, G., Woerther, Patrice, Seibert, C., Feuillet, N., Ratzov, Gueorgui, Beck, C., Morena, Pierre, Johannes, L., Ducassou, E., Cattaneo, Antonio, Goldfinger, C., Moreno, E., Bieber, A., Bénâtre, G., Caron, B., Caron, M., Casse, M., Cavailhes, T., Del Manzo, G., Deschamps, C. E., Desiage, P. A., Duboc, Q., Fauquembergue, K., Ferrant, Anthony, Guyard, H., Jacques, E., Laurencin, M., Leclerc, F., Patton, J., Saurel, J. M., St‐onge, G., and Woerther, Patrice

Abstract

The seismic potential of the Lesser Antilles subduction zone is poorly known and highly debated. Only two damaging earthquakes have been reported in the historical period, in 1839 and 1843, but their sources and magnitude are still uncertain. Global Navigation Satellite Systems and coral data contradict each other, and no conclusion has been reached on the coupling ratio of the plate interface. Given the threat posed by the possible occurrence of a large megathrust earthquake, it is crucial to gain information on prehistorical events. We present the results of a submarine paleoseismological study that covers an exceptional ∼120 Kyr‐long period. We studied the sediments sampled in six up to 26 m‐long piston cores collected in deep fore‐arc basins located over the epicentral region of the 1843 earthquake. Using a multiproxy approach combining geophysical, geochemical, and sedimentological analysis, biostratigraphy and radiocarbon dating, we identified, characterized, and dated numerous event deposits that we then correlated with the sampled basins over an up to 160 km‐long area. We show that at least 33 earthquakes likely triggered these sediment remobilizations in the last 120 Kyr. Four of these events promoted exceptional deposits of turbidites + homogenites. From peak ground acceleration calculated for potential earthquakes occurring on various faults, and the absence of deposits linked to the historical earthquakes, we propose that the sources are likely megathrust earthquakes. Over the last 60 Kyr, we inferred at least three 15–25 Kyr‐long seismic cycles in which the recurrence times of earthquakes shortens from ∼5 to ∼2 Kyr.

Published
2024
Full Text
View/download PDF

50. Sedimentary Records in the Lesser Antilles Fore‐Arc Basins Provide Evidence of Large Late Quaternary Megathrust Earthquakes

Author

Seibert, C., primary, Feuillet, N., additional, Ratzov, G., additional, Beck, C., additional, Morena, P., additional, Johannes, L., additional, Ducassou, E., additional, Cattaneo, A., additional, Goldfinger, C., additional, Moreno, E., additional, Bieber, A., additional, Bénâtre, G., additional, Caron, B., additional, Caron, M., additional, Casse, M., additional, Cavailhes, T., additional, Del Manzo, G., additional, Deschamps, C. E., additional, Desiage, P. A., additional, Duboc, Q., additional, Fauquembergue, K., additional, Ferrant, A., additional, Guyard, H., additional, Jacques, E., additional, Laurencin, M., additional, Leclerc, F., additional, Patton, J., additional, Saurel, J. M., additional, St‐Onge, G., additional, and Woerther, P., additional

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results